Conjugates of phthalocyanine dyes with antibodies or peptides

A phthalocyanine dye conjugate with an antibody effectively targets and kills cancer cells through photoimmunotherapy by generating cytotoxic reactive oxygen species upon light activation, addressing the limitations of existing methods in suppressing cancer cell proliferation.

JP7760124B2Active Publication Date: 2025-10-27THE UNIV OF TOKYO +1
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Patent Information

Application Number
JP2021575859
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2020-02-05
Filing Date
2021-02-04
Publication Date
2025-10-27
Estimated Expiration
2041-02-04

AI Technical Summary

Technical Problem

Existing photoimmunotherapy methods using phthalocyanine dyes are limited in their ability to effectively suppress cancer cell proliferation and induce cell death.

Method used

Development of a phthalocyanine dye conjugate with an antibody, specifically targeting cancer cells, which is administered and activated with light to generate cytotoxic reactive oxygen species, thereby inhibiting cell proliferation or inducing cell death.

Benefits of technology

The phthalocyanine dye conjugate effectively suppresses cancer cell proliferation and induces cell death by generating cytotoxic reactive oxygen species upon light activation, providing a novel therapeutic approach for cancer treatment.

✦ Generated by Eureka AI based on patent content.

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Patent Text Reader

Abstract

The present invention addresses the problem of providing a novel phthalocyanine dye to be used in photoimmunotherapy, a method for producing same, and a conjugate between a peptide or an antibody and said phthalocyanine dye. The present invention provides a compound represented by formula (1) or a salt thereof. (In the formula, X represents a substituent having a hydrophilic group at an end. L3, L4, L5, and L6 each independently represent a divalent linkage group. Y represents a group that can bind with an antibody or a peptide. R3 represents a substituent such as an alkyl group having 1-6 carbon atoms, an alkoxy group having 1-6 carbon atoms, a halogen atom, -SR11, -SOR12, an aryl group having 6-10 carbon atoms, -N(R13)(R14), or -NO2. If there is more than one R3, they may be identical or different from each other. "s" represents an integer of 0-4.)
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Citation Information

Patent Citations

  • Axial nucleoside asymmetrically-modified silicon phthalocyanine and preparation method and application thereof

    CN103435639A

  • Axially substitutive silicon phthalocyanine complex and doxorubicin conjugate thereof

    CN105669735A

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    CN107226839A

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