Ketohexokinase (KHK) iRNA compositions and methods of use thereof
JP7797547B2Active Publication Date: 2026-01-13ALNYLAM PHARMACEUTICALS INC
Patent Information
- Application Number
- JP2024008864
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2018-09-18
- Filing Date
- 2024-01-24
- Publication Date
- 2026-01-13
- Estimated Expiration
- 2039-09-17
Smart Images
Figure 0007797547000053 
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Abstract
To provide a RNAi agent targeting a ketohexokinase (KHK) gene.SOLUTION: A double-stranded ribonucleic acid (dsRNA) agent for inhibiting expression of a ketohexokinase (KHK) gene includes a sense strand and an antisense strand. The sense strand includes a nucleotide sequence having a specific sequence and at least 15 of continuous nucleotides in which three or less of nucleotides are different, and the antisense strand includes a nucleotide sequence having a specific sequence and at least 15 of continuous nucleotides in which three or less of nucleotides are different. The present invention further provides a method of using an RNAi agent for inhibiting KHK gene expression in a subject, and a treatment method or a prevention method of a KHK-related disease.SELECTED DRAWING: None
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Citation Information
Patent Citations
Ketohexokinase (KHK) iRNA composition and method of use thereof
JP2017509354A