Heteroalicyclic derivatives and their use in the treatment of CNS disorders

Heteroalicyclic piperazine and piperidine derivatives address the limitations of current antipsychotics by functioning as multi-receptor antagonists, effectively treating CNS disorders with reduced side effects and improved safety.

JP7828459B2Active Publication Date: 2026-03-11SUVEN LIFE SCI LTD
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Filing Date
2023-01-11
Publication Date
2026-03-11

AI Technical Summary

Technical Problem

Current antipsychotic medications for CNS disorders like schizophrenia and bipolar disorder have significant side effects such as involuntary movement disorders, cognitive slowing, and increased mortality in elderly patients with dementia, necessitating the development of novel compounds with improved therapeutic selectivity and safety profiles.

Method used

Development of heteroalicyclic substituted piperazine and piperidine derivatives that act as dopamine D2, 5-HT1A, and 5-HT2A receptor antagonists, and serotonin reuptake inhibitors, reducing the risk of side effects like extrapyramidal symptoms and tardive dyskinesia.

Benefits of technology

The compounds demonstrate efficacy in animal models of schizophrenia and related disorders, attenuating cognitive deficits while minimizing side effects, offering a safer treatment option for CNS disorders.

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Abstract

The present invention relates to heteroalicyclic compounds represented by the general formula (I), or their isotopes, stereoisomers, or pharma- ceutically acceptable salts. The present invention also describes methods for making such compounds, pharmaceutical compositions containing such compounds, and their use for the treatment or prevention of central nervous system related disorders. JPEG2025504406000073.jpg38170
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Citation Information

Patent Citations

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    CN105367565A

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    EP0453042A1

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