Charged depth filters for therapeutic biotechnology manufacturing processes
The charged depth filter addresses clogging issues in high-density cell cultures by using layers with controlled pore sizes and charge capacities, ensuring efficient clarification and reduced turbidity with enhanced throughput.
JP7832220B2Active Publication Date: 2026-03-17SOLVENTUM INTELLECTUAL PROPERTIES CO
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Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2022-02-24
- Publication Date
- 2026-03-17
Abstract
1. A charged depth filter for removing cells and / or cellular debris from a biopharmaceutical feedstock, comprising: a first functionalized nonwoven layer having a first calculated pore size and a first dynamic charge capacity; and a second functionalized nonwoven layer having a second calculated pore size and a second dynamic charge capacity disposed after the first functionalized nonwoven layer in a direction of flow of the biopharmaceutical feedstock, wherein the first calculated pore size is larger than the second calculated pore size and the first dynamic charge capacity is smaller than the second dynamic charge capacity.
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