organic compounds

JP7856707B2Active Publication Date: 2026-05-11INTRA CELLULAR THERAPIES INC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
INTRA CELLULAR THERAPIES INC
Filing Date
2024-08-21
Publication Date
2026-05-11

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Abstract

To provide immune system cells including macrophages and microglia, and pharmaceuticals for suppressing recruitment of other cells to cancer.SOLUTION: The present invention provides a pharmaceutical for suppressing macrophage or microglial recruitment to metastatic cells, comprising a PDE1 inhibitor. Preferably, the pharmaceutical is administered in combination with a checkpoint inhibitor. Preferably, the checkpoint inhibitor is an inhibitor of CTLA-4, PD-1 and / or PD-L1.SELECTED DRAWING: None
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