Systems and methods for sterile sampling and liquid addition
The sampling system with a graduated chamber and sterile air filter addresses the challenges of precise and sterile fluid handling in bioreactors by enabling controlled, contamination-free sampling and addition of fluids.
JP7865956B2Active Publication Date: 2026-05-26GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
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Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- Filing Date
- 2021-10-27
- Publication Date
- 2026-05-26
AI Technical Summary
Technical Problem
Existing methods for aseptic sampling from bioreactors are elaborate, costly, and time-consuming, and risk contaminating the culture vessel due to potential leaks or exposure to air, with stopcock designs unable to precisely control the volume collected.
Method used
A sampling system with a graduated sampling chamber, pump device, and sterile air filter that allows for the selective drawing and pushing of a fixed amount of fluid without contact with the pump, using unidirectional valves to ensure sterility and precise volume control.
Benefits of technology
Enables sterile, efficient, and precise sampling and addition of fluids in a functionally closed manner, reducing the risk of contamination and ensuring accurate volume measurement.
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Abstract
The sampling system includes a graduated sampling chamber configured for fluid connection to a sample source, a pump device configured for fluid connection with the sampling chamber, and a sterile air filter intermediate the pump device and the sampling chamber, wherein the pump device is selectively operable to draw a volume of fluid from the sample source into the sampling chamber.
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