RNA constructs
RNA constructs encoding viral immunosuppressive proteins address innate immune sensing challenges, enhancing protein expression and therapeutic efficacy by inhibiting innate immune responses.
JP7865987B2Active Publication Date: 2026-05-26IMPERIAL COLLEGE INNVOATIONS LTD
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- IMPERIAL COLLEGE INNVOATIONS LTD
- Filing Date
- 2021-12-17
- Publication Date
- 2026-05-26
AI Technical Summary
Technical Problem
Existing mRNA and saRNA therapeutics face challenges in overcoming innate immune sensing, leading to interferon induction and reduced protein expression in humans, limiting their therapeutic potential.
Method used
Development of RNA constructs encoding viral immunosuppressive proteins that inhibit innate immune responses, allowing for improved translation and self-amplification of target genes, such as antigens, by co-localizing the therapeutic biomolecule with innate inhibitory proteins within host cells.
Benefits of technology
Enhances protein expression levels of target genes by up to 12-fold in human cell lines, overcoming innate immune inhibition and enabling higher therapeutic efficacy.
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Smart Images
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Abstract
The present invention relates to RNA constructs, particularly but not exclusively to mRNA constructs and saRNA replicons, as well as nucleic acids and expression vectors encoding such RNA constructs.The present invention extends to the use of such RNA constructs in therapy, for example in treating disease and / or in vaccine delivery.The present invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.
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