Disinfection components

Abstract

To provide a disinfecting composition having high persistence of moisturizing effect after hand washing, excellent bactericidal effect, sense of use, and formulation stability.SOLUTION: There is provided a disinfecting composition which comprises a component A: an ester oil, a component B: a hydrophobized hydroxyalkyl cellulose, a component C: a cationic bactericide and no ethanol, wherein the content of the component A is 0.1 to 40 mass%, the content of the component B is 0.01 to 15 mass%, the content of the component C is 0.001 to 1 mass% and when the content of the component A is defined as 1 pts.mass, the content of the component D preferably is 1 / 4000 pts.mass or more and 150 pts.mass or less.SELECTED DRAWING: None

Description

[Technical Field]

[0001] This invention relates to a disinfectant composition. [Background technology]

[0002] It has been generally known that lower alcohols with 1 to 3 carbon atoms, such as ethanol and isopropyl alcohol, have a disinfecting effect against bacteria and viruses by destroying bacterial cell membranes and viral envelopes, and by coagulating proteins such as enzymes. Disinfectant compositions containing these lower alcohols are widely known. However, disinfectant compositions generally containing lower alcohols with 1 to 3 carbon atoms, such as ethanol and isopropyl alcohol, have the problem of causing skin irritation and other skin problems. Skin irritation refers to a condition in which the stratum corneum and lipid membrane are removed, the stratum corneum is broken, and the skin barrier function is impaired. In this condition, bacteria and viruses can easily enter through the damaged areas of the barrier, making the skin more susceptible to infection. For this reason, there is a demand for disinfectant compositions with excellent moisturizing properties that can prevent skin irritation, i.e., a decrease in skin barrier function, while maintaining disinfectant effectiveness.

[0003] In order to impart a skin-soothing effect to disinfectant compositions, attempts have been made to incorporate moisturizing ingredients such as glycerin, propylene glycol, and sorbitol (for example, Patent Document 1), or to incorporate moisturizing ingredients (water-soluble polyhydric alcohols) and fatty acid triglycerides (for example, Patent Document 2). [Prior art documents] [Patent Documents]

[0004] [Patent Document 1] Japanese Patent Publication No. 2004-155712 [Patent Document 2] Japanese Patent Publication No. 2011-219410 [Overview of the Initiative] [Problems that the invention aims to solve]

[0005] However, hands are constantly prone to dryness due to everyday activities such as washing hands and touching objects. Conventional disinfectant compositions have low sustained moisturizing effects after hand washing and are not sufficient for preventing dry or chapped hands.

[0006] Another option is to use a cationic disinfectant such as benzalkonium chloride, which has a high disinfecting effect, instead of lower alcohol, which is a major cause of skin irritation. However, when incorporating a cationic disinfectant, there have been problems such as the disinfecting effect being inhibited depending on the balance of other components in the composition. Therefore, the present invention aims to provide a disinfectant composition that offers long-lasting moisturizing effects after hand washing, as well as excellent bactericidal effect, user experience, and formulation stability. [Means for solving the problem]

[0007] The disinfectant composition according to the present invention is composed of component A: Isotridecyl isononanoate It contains, and component B: hydrophobized hydroxyalkylcellulose and component C: cationic disinfectant. It does not contain ethanol. The content of component A is 0.1 to 40% by mass, The content of component B is 0.01 to 15% by mass, The content of component C is 0.001 to 1% by mass. the law of nature, It is a cream-type formulation. ru. [Effects of the Invention]

[0008] According to the present invention, it is possible to provide a disinfectant composition that offers long-lasting moisturizing effects after hand washing, as well as excellent bactericidal effect, user experience, and formulation stability. [Modes for carrying out the invention]

[0009] The following describes in detail preferred embodiments of the disinfectant composition of the present invention. The disinfectant composition of the present invention is characterized by containing predetermined amounts of component A: ester oil, component B: hydrophobized hydroxyalkyl cellulose, and component C: cationic disinfectant, and not containing ethanol. The properties of the disinfectant composition of the present invention are not particularly limited, and may be liquid, gel, emulsion, cream, etc. Among these, a cream is preferred.

[0010] <Ingredient A> The disinfectant composition of the present invention contains 0.1 to 40% by mass of ester oil as component A. By including the above-mentioned amount of component A, the moisturizing effect can be maintained even after washing hands with soap.

[0011] Examples of ester oils include glyceryl tricaprylate, glyceryl tri-2-ethylhexanoate, isononyl isononanoate, ethylene glycol dioctanoate, caprylic / capric triglyceride, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, butyl stearate, ethyl oleate, ethyl linoleate, isopropyl linoleate, cetyl caprylate, decyl myristate, hexyl laurate, myristyl myristate, cetyl myristate, cetyl palmitate, and stearate. Lyl, oleyl oleate, decyl oleate, cetyl ricinoleate, isostearyl laurate, isotridecyl myristate, isotridecyl isononanoate, isocetyl myristate, isostearyl myristate, 2-octyldodecyl myristate, octyl palmitate, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, 2-octyldodecyl oleate, 2-octyldodecyl ricinoleate, ethyl isostearate, isopropyl isostearate, cetyl octanoate, cetyl octanoate Stearyl ester, stearyl octanoate, hexyl isostearate, ethylene glycol dioleate, propylene glycol dicaprate, di(caprylic / capric acid)propylene glycol, propylene glycol dioleate, neopentyl glycol dicaprate, cetyl 2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate Pentaerythritol tetra-2-ethylhexanoate, pentaerythritol tetramyristate, pentaerythritol tetraisostearate, 2-octyldodecyl neopentanoate, isocetyl octanoate, isostearyl octanoate, 2-hexyldecyl neodecanoate, 2-octyldodecyl neodecanoate, octyl isopalmitate, isocetyl isostearate, isostearyl isostearate, 2-octyldodecyl isostearate, lauryl lactate, myristyl lactate, cetyl lactate, 2-octyldodecyl lactate, triethyl citrate,Examples include acetyltriethyl citrate, acetyltributyl citrate, tri-2-ethylhexyl citrate, triisocetyl citrate, tri-2-octyldodecyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, dioctyl succinate, diisopropyl adipate, diisobutyl adipate, dioctyl adipate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, dibutyloctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, hexyldecyl dimethyloctanoate, diethyl phthalate, dibutyl phthalate, and dialkyl carbonate. One or more of these can be used in combination.

[0012] Among these, it is preferable to use at least one selected from the group consisting of isopropyl palmitate, isopropyl myristate, isotridecyl isononanoate, and cetyl 2-ethylhexanoate as component A. By using these components, the duration of the moisturizing effect after hand washing can be increased without impairing the bactericidal effect of component C, which will be described later.

[0013] The content of component A in the disinfectant composition is 0.1 to 40% by mass, but preferably 1 to 30% by mass, and more preferably 3 to 20% by mass. This makes it possible to extend the duration of the moisturizing effect after hand washing without impairing the bactericidal effect of component C, which will be described later.

[0014] <Component B> The disinfectant composition of the present invention contains 0.01 to 15% by mass of hydrophobized hydroxyalkylcellulose as component B. By including the above-mentioned amount of component B, it is possible to improve the feel and stability of the formulation without impairing the bactericidal effect of component C, which will be described later.

[0015] Hydrophobized hydroxyalkyl cellulose is obtained by introducing a long-chain alkyl group as a hydrophobic group into hydroxyalkyl cellulose. Examples of the hydroxyalkyl cellulose include hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose and the like. Examples of the hydrophobic group include a stearyl group, a cetyl group and the like. Among these, as component B, it is preferable to use hydrophobized hydroxypropyl methyl cellulose, and more preferably to use stearoxy hydroxypropyl methyl cellulose. Thereby, without impairing the bactericidal effect of component C described later, the feeling of use and the stability of the preparation can be made more excellent.

[0016] The content of component B in the disinfecting composition is 0.01 to 15% by mass, preferably 0.05 to 10% by mass, and more preferably 0.1 to 1% by mass. Thereby, without impairing the bactericidal effect of component C described later, the feeling of use and the stability of the preparation can be made more excellent.

[0017] Also, when the content of component A described above is 1 part by mass, the content of component B is preferably 1 / 4000 part by mass or more and 150 parts by mass or less, more preferably 1 / 600 part by mass or more and 10 parts by mass or less, and even more preferably 1 / 200 part by mass or more and 1 / 3 part by mass or less. Thereby, while making the persistence of the moisturizing effect after hand washing more excellent, the feeling of use and the stability of the preparation can be made more excellent.

[0018] <Component C> The disinfecting composition of the present invention contains 0.001 to 1% by mass of a cationic bactericide as component C. By containing component C in the above predetermined amount, a preparation excellent in bactericidal properties can be obtained. Examples of cationic disinfectants include quaternary ammonium salts such as cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, decalinium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, lauryltrimethylammonium chloride, and laurylpyridinium chloride, as well as biguanide disinfectants such as alexidine gluconate, alexidine hydrochloride, alexidine acetate, chlorhexidine hydrochloride, chlorhexidine acetate, chlorhexidine hydrochloride, and chlorhexidine gluconate. One or more of these can be used in combination.

[0019] Among these, Component C It is preferable to use benzalkonium chloride and / or benzethonium chloride. This allows for superior usability and stability of the formulation while exhibiting higher bactericidal activity.

[0020] The content of component C in the disinfectant composition is 0.001 to 1% by mass, but preferably 0.005 to 0.5% by mass, and more preferably 0.01 to 0.3% by mass. This makes it possible to improve the bactericidal effect more effectively while also improving the feel and stability of the formulation.

[0021] <Ethanol> The disinfectant composition of the present invention does not contain ethanol. This helps to suppress the occurrence of skin irritation. In this specification, "ethanol-free" means that the ethanol content in the disinfectant composition is 0.5% by mass or less. Furthermore, it is preferable that the product does not contain any lower alcohols other than ethanol (alcohols with 3 or fewer carbon atoms, such as isopropanol). This will more reliably suppress the occurrence of skin irritation.

[0022] <Component D> The disinfectant composition of the present invention preferably contains a glycerin fatty acid ester as component D. Including such component D allows for a longer-lasting moisturizing effect even after hand washing. Furthermore, it improves the feel and stability of the formulation. Examples of glycerin fatty acid esters include monoglyceryl monocaprylate, glyceryl monocaprate, glyceryl monolaurate, glyceryl monomyristate, glyceryl monopalmitate, glyceryl monostearate, glyceryl distearate, glyceryl monoisostearate, glyceryl diisostearate, glyceryl monohydroxystearate, glyceryl monooleate, glyceryl monobehenate, glyceryl dibehenate, and other monoglycerin fatty acid esters, as well as polyglyceryl monostearate. Ceryl (Diglyceryl monostearate (Polyglyceryl-2 stearate), Tetraglyceryl monostearate (Polyglyceryl-4 stearate), Pentaglyceryl monostearate (Polyglyceryl-5 stearate), Hexaglyceryl monostearate (Polyglyceryl-6 stearate), Decaglyceryl monostearate (Polyglyceryl-10 stearate), etc.), Polyglyceryl monooleate (Diglyceryl monooleate, Tetraglyceryl monooleate, Monooleate Polyglycerin fatty acid monoesters such as hexaglyceryl, decaglyceryl monooleate, polyglyceryl monolaurate (hexaglyceryl monolaurate, decaglyceryl monolaurate, etc.), polyglyceryl monomyristate (hexaglyceryl monomyristate, decaglyceryl monomyristate, etc.), and diglyceryl monoisostearate; polyglycerin fatty acid diesters such as diglyceryl dioleate, decaglyceryl distearate, and decaglyceryl diisostearate; Tris Examples include polyglycerin fatty acid triesters such as tetraglyceryl thearate, hexaglyceryl tristearate, decaglyceryl tristearate, and decaglyceryl trioleate; and polyglycerin fatty acid esters such as tetraglyceryl pentastearate, tetraglyceryl pentaoleate, hexaglyceryl pentastearate, and hexaglyceryl pentaoleate. One or more of these can be used in combination.

[0023] Among these, the use of polyglycerin fatty acid monoesters is preferred, the use of polyglyceryl monostearate is more preferred, and the use of polyglyceryl-5 stearate is even more preferred.

[0024] The content of component D is preferably 0.01 to 15% by mass, more preferably 0.1 to 10% by mass, and even more preferably 1 to 5% by mass. This can improve the stability of the formulation and the duration of its moisturizing effect.

[0025] When the content of component A described above is 1 part by mass, the content of component D is preferably 1 / 4000 parts by mass or more and 150 parts by mass or less, more preferably 1 / 3000 parts by mass or more and 10 parts by mass or less, and even more preferably 1 / 20 parts by mass or more and 5 / 3 parts by mass or less. This makes it possible to have excellent sustained moisturizing effect and feel while also achieving particularly excellent stability of the formulation.

[0026] <Other ingredients> Furthermore, in addition to the above-mentioned components, the disinfectant composition of the present invention may contain other components commonly used depending on the purpose and dosage form. Examples of such ingredients include hyaluronic acid, hyaluronic acid salts, heparinoids, nicotinamide, antioxidants, mineral and synthetic oils, animal and vegetable oils, waxes, fatty acids, alcohols (excluding lower alcohols), high molecular weight compounds, animal and plant extracts, amino acids, solvents, anti-inflammatory agents, preservatives, UV protectants, metal ion chelating agents, antioxidants, pH adjusters, dyes and pigments, and fragrances, which can be incorporated within limits that do not impair the effects of the present invention. Specific examples are given below.

[0027] (Antioxidant) Examples of antioxidants include vitamin E and its derivatives (dl-α(β,γ)-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, dl-α-tocopherol linoleate, dl-α-tocopherol succinate, and other tocopherols and their derivatives, ubiquinones, etc.), vitamin A and its derivatives (retinol and its derivatives such as retinyl palmitate and retinyl acetate, retinal and its derivatives such as dehydroretinal, etc.), carotenoids (carotene, lycopene, astaxanthin, etc.), vitamin B and its derivatives (thiamine, etc.) Examples include hydrochloride salts, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as benzyl nicotinate, choline, etc., vitamin C and its derivatives (L-ascorbyl dipalmitate, L-ascorbyl tetraisopalmitate alkyl esters, L-ascorbyl phosphate esters, L-ascorbyl sulfate esters, etc.), vitamin D and its derivatives (ergocalciferol, cholecalciferol, dihydroxystanal, etc.), rutin and its derivatives, thiotaurine, taurine, hydroquinone and its derivatives, histidine, catechin and its derivatives, glabridin, glabrene, liquiritin, isoliquiritin, and licorice extracts containing these.

[0028] (Mineral and synthetic oils) Examples of mineral and synthetic oils include liquid paraffin, liquid isoparaffin, petrolatum, paraffin, ceresin, microstarin wax, α-olefin oligomer, polyethylene, polybutene, and synthetic squalane. One or more of these can be used in combination.

[0029] (animal and vegetable oil) Examples of animal and vegetable oils include squalane, olive oil, camellia oil, wheat germ oil, jojoba oil, avocado oil, carrot oil, shea butter, liquid shea butter, palm oil, palm kernel oil, hydrogenated oil, horse oil, lanolins, egg yolk oil, clove oil, rosehip oil, lavender oil, peppermint oil, spearmint oil, rosemary oil, macadamia nut oil, apricot kernel oil, safflower oil, safflower oil (2), sunflower oil, sunflower oil (2), meadowfoam oil, almond oil, perilla oil, sesame oil, borage oil, cocoa butter, rice bran oil, rice germ oil, and fennel. Examples of oils include orange oil, chamomile oil, cucumber oil, kukui nut oil, soybean oil, tea tree oil, corn oil, rapeseed oil, peach kernel oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, argania spinosa kernel oil, crambe abyssinica seed oil, almond oil, peach kernel oil, grapeseed oil, emu oil, mink oil, hemp seed oil, linseed oil, camellia oil, Japanese wax, coconut oil, evening primrose oil, pistachio seed oil, mango butter, etc., and one or more of these can be used in combination.

[0030] (Waxes) Examples of waxes include jojoba oil, beeswax, carnauba wax, rice bran wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac, and orange roughy oil. One or more of these can be used in combination.

[0031] (fatty acid) Examples of fatty acids include natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, behenic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, and lanolinic acid, as well as synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, and isopentanoic acid. One or more of these can be used in combination.

[0032] (alcohol) The disinfectant composition of the present invention may contain alcohols other than lower alcohols such as ethanol and isopropanol. Examples of such alcohols include butyl alcohol, benzyl alcohol, lauryl alcohol, myristyl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, hexyldecanol, behenyl alcohol, octyldodecanol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol, 2-octyldodecanol, batyl alcohol, etc., and one or more of these can be used in combination.

[0033] (Silicone oil) Examples of silicone oils include methylpolysiloxane, methylphenylpolysiloxane, silicone resins, methylhydrogenpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, cyclic silicone resins, octamethyltrisiloxane, tetradecamethylhexasiloxane, highly polymerized methylpolysiloxane, trimethylsiloxysilicate, poly(oxyethylene / oxypropylene)methylpolysiloxane copolymer, poly(oxyethylene / oxypropylene) / butylene / methylpolysiloxane copolymer, polyoxyethylene / methylpolysiloxate copolymer, polyoxypropylene / methylpolysiloxane copolymer, dimethylsiloxane / methylcetyloxysiloxane copolymer, and dimethylsiloxane / methylstearoxysiloxane copolymer. One or more of these can be used in combination.

[0034] (Surfactants) It may also contain surfactants other than component D mentioned above. Examples of such surfactants include lauryl sulfate, alkyl sulfate, polyoxyethylene alkyl sulfate, tetradecene sulfonate, polyoxyethylene alkyl sulfosuccinate, lauroyl sarcosine salt, alkylmethyl-β-alanine salt, polyoxyethylene alkyl ether phosphate, fatty acid soap, N-acyl glutamate, lauric acid diethanolamide, coconut oil fatty acid diethanolamide, alkyldimethylamine oxide, alkylmethyl taurate salt, alkylaminoprocyonate, polyoxyethylene alkyl ether carboxylate, alkyl phosphate, alkyl glucoside, polyether-modified silicone, alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, and Examples include midamine, dialkyldimethylammonium dimethyl acetate betaine, alkylamidopropyl betaine, alkylcarboxymethylhydroxyethylimidazolinium betaine, lecithin (soybean or egg yolk) and its derivatives, propylene glycol fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene hydrogenated castor oil, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl nonylphenyl ether, polyoxyethylene alkyl ether phosphate / phosphate, sucrose fatty acid ester, etc., and one or more of these can be used in combination.

[0035] (Humectant) Examples of wetting agents include glycerin, diglycerin, polyglycerin, 1,3-butylene glycol, polyethylene glycol, 1,2-pentanediol, 1,3-hexanediol, propylene glycol, dipropylene glycol, isopropylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, maltitol, reduced starch syrup, lactitol, palatinite, erythritol, sorbitol, mannitol, xylitol, xylose, trehalose, glycoside trehalose, glucose, glucose, lactose, mannose, maltose, fructose, inositol, pentaerythritol, maltotriose, starch-derived sugars, starch-derived sugar-reduced alcohols, ethylene oxide, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monoethyl ether, propylene oxide, water-soluble proteoglycans, collagen, ceramide, etc., and one or more of these can be used in combination.

[0036] (polymer compound) It may also contain polymer compounds other than component B mentioned above. Examples of high molecular weight compounds include sodium alginate, carrageenan, agar, ferceleran, guar gum, quince seed, konjac mannan, tamarind gum, tara gum, dextrin, starch, locust bean gum, gum arabic, guatti gum, karaya gum, tragacanth gum, arabinogalactan, pectin, quince, wheat protein, soy protein, albumin, casein, gelatin, chitosan, hyaluronic acid, curdlan, xanthan gum, gellan gum, cyclodextrin, dextran, pullulan, and crystalline cells. Examples include rose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, cationized cellulose, cationized guar gum, hydroxypropylated guar gum, carboxyvinyl polymer, polyacrylamide, sodium polyacrylate, polyethyleneimine, highly polymerized polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, etc., and one or more of these can be used in combination.

[0037] (Animal and plant extracts) Examples of plant and animal extracts include placenta extract, hydrolyzed keratin, hydrolyzed silk, yeast extract, aloe extract, comfrey extract, peony extract, perilla extract, sage extract, swertia japonica extract, witch hazel water, Isodon japonicus extract, hop extract, horse chestnut extract, peach leaf extract, saxifrage extract, lemon balm extract, mugwort extract, rosemary extract, and rice bran fermentation extract. One or more of these can be used in combination.

[0038] (Amino acids) Examples of amino acids include L-alanine, L-arginine, L-aspartic acid, L-glutamine, L-asparagine, L-cysteine, L-serine, L-tyrosine, L-proline, pyrrolidone carboxylate, glycine, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, cystine, hydroxyproline, hydroxylysine, ornithine, histidine, γ-aminobutyric acid, ε-aminocaproic acid, etc., and one or more of these can be used in combination.

[0039] (solvent) Examples of solvents include purified water and tap water, and one or more of these can be used in combination.

[0040] (Anti-inflammatory agent) Examples of anti-inflammatory agents include glycyrrhizic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate, guaiazulene, sodium guaiazulene sulfonate, allantoin, ε-aminocaproic acid, and tranexamic acid. One or more of these can be used in combination.

[0041] (Preservative) Examples of preservatives include methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, phenoxyethanol, bisabolol, hinokitiol, benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, sorbic acid, potassium sorbate, undecylenic acid, pionin, l-menthol, d-camphor, isopropylmethylphenol, benzethonium chloride, alkyldiaminoethylglycine hydrochloride, and ethylhexylglycerin. One or more of these can be used in combination.

[0042] (UV protection agent) Examples of UV-blocking agents include para-aminobenzoic acid, ethyl para-aminobenzoate, glyceryl para-aminobenzoate, 2-ethylhexyl para-dimethylaminobenzoate, oxybenzone, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone sulfonate, sodium hydroxymethoxybenzophenone sulfonate, octyl salicylate, 4-tert-butyl-4'-methoxydibenzoylmethane, ferulic acid, titanium dioxide, fine-particle titanium dioxide, zinc oxide, fine-particle zinc oxide, etc., and one or more of these can be used in combination.

[0043] (Metal ion sequestering agent) Examples of metal ion chelating agents include EDTA, EDTA salts, trisodium ethylenediaminehydroxyethyl triacetate, diethylenetriaminepentaacetic acid, pentasodium diethylenetriaminepentaacetic acid, ethylenediaminetetrakis(2-hydroxyisopropyl) dioleate, hydroxyethanediphosphonic acid, tetrasodium hydroxyethanediphosphonic acid, and phytic acid. One or more of these can be used in combination.

[0044] (Antioxidant) Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, erythorbic acid, propyl gallate, and d-δ-tocopherol, and one or more of these can be used in combination.

[0045] (pH adjuster) Examples of pH adjusting agents include citric acid, glycolic acid, malic acid, tartaric acid, lactic acid, succinic acid, phosphoric acid, and their salts, and one or more of these can be used in combination.

[0046] (Pigment) Examples of organic pigments include azo pigments and phthalocyanine pigments, and lake-formed versions are also used. Examples of organic pigments include organic pigment powders such as Red 201, Red 202, Red 205, Red 226, Red 228, Orange 203, Orange 204, Blue 404, and Yellow 401, as well as zirconium, barium, or aluminum lakes such as Red 3, Red 104, Red 106, Orange 205, Yellow 4, Yellow 5, Green 3, and Blue 1. Examples of inorganic pigments include anhydrous silicic acid, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium dioxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, ultramarine, chromium oxide, chromium hydroxide, carbon black, calamine, cerium oxide, barium sulfate iron oxide, and Prussian blue.

[0047] The disinfectant compositions of the present invention have been described above, but the present invention is not limited thereto. [Examples]

[0048] Next, specific embodiments of the present invention will be described. <Manufacturing of disinfectant compositions> (Examples 1-9, Comparative Examples 1-9) A cream-type disinfectant composition was prepared using the ingredients and proportions shown in Tables 1 and 2, according to conventional methods. In Tables 1 and 2, hydrophobized HPMC refers to stearohydroxypropyl methylcellulose. Polyglyceryl-5 stearate was used as the polyglyceryl monostearate.

[0049] <Rating> (Moisture evaluation after washing with soap) The evaluation was conducted according to the following procedure. (1) The keratin moisture content (initial value) of the inner forearm of two sensory evaluators was measured. (2) 15 mg of the disinfectant composition of each example and each comparative example was applied. (3) Three hours later, the amount of keratin moisture was measured after washing with soap. (4) When the change in the amount of horny layer moisture from the initial value was converted to a percentage, the average value of two subjects when defined as "compared to the initial" was evaluated according to the following evaluation criteria. A: Compared to the initial is 250% or more B: Compared to the initial is 200% or more and less than 250% C: Compared to the initial is 140% or more and less than 200% D: Compared to the initial is 135% or more and less than 140% E: Compared to the initial is less than 135%

[0050] (Evaluation of bactericidal effect) Escherichia coli NBRC3972 was pre-cultured in SCD medium at 32.5 °C for 24 hours to obtain a culture solution. The obtained culture solution was diluted with physiological saline so that the number of bacteria became 10 8 CFU / mL, and then 1 / 100 volume of the culture solution prepared for 20 g of the disinfection composition of each example and each comparative example was added and mixed to obtain a mixed solution. After 3 minutes, 1 mL of each obtained mixed solution was serially diluted with 9 mL of LP diluent to obtain a diluted solution. 1 mL of each obtained diluted solution was mixed with TSA medium, and the number of viable bacteria was determined by the pour plate culture method. Here, the pour plate culture method is to mix and coagulate the sample solution and the agar medium in a petri dish, culture it at 32.5 °C under aerobic conditions, visually measure the number of colonies generated after culture, and multiply by a multiplier to obtain the number of viable bacteria. Based on the number of viable bacteria, evaluation was carried out according to the following evaluation criteria. A: Less than 1.0×10 2 CFU / mL B: 1.0×10 2 CFU / mL or more and less than 1.0×10 3 CFU / mL C: 1.0×10 3 CFU / mL or more and less than 5.0×10 3 CFU / mL D: 5.0×10 3 CFU / mL or more and less than 1.0×10 4 CFU / mL E: 1.0×10 4 CFU / mL or more

[0051] (Evaluation of stability) The disinfectant compositions of each example and comparative example were stored at 40°C for one month, and their stability was evaluated by visual inspection according to the following criteria. A: It is not separated at all and is in a uniform state. B: Slightly separated but mostly uniform. C: Slightly separated and somewhat uneven in state. D: It is somewhat separated and in an uneven state. E: Completely separated and in a non-uniform state.

[0052] (Evaluation of user experience) The disinfectant compositions of each example and comparative example were evaluated according to the following evaluation criteria for "ease of spreadability," "non-stickiness," and "balance between hardness and finger resistance." A: Good B: Fairly good C: I can't say either way. D: Slightly bad E: Bad

[0053] (comprehensive evaluation) Based on the evaluations of the four items above—"Moisture-retaining effect after washing with soap," "Antibacterial effect," "Stability," and "User experience"—the evaluation was conducted according to the following evaluation criteria. A: There are no E's and there are three or more A's. B: There are no E's and there are two A's. C: There are no E's and there is one A. D: There are no E's and no A's. E: There is one or more E These results are shown in Table 1.

[0054] [Table 1] [Table 2]

[0055] As can be seen from Tables 1 and 2, the disinfectant composition of the present invention exhibited excellent moisturizing properties even after washing with soap, as well as superior bactericidal effect, formulation stability, and usability, making it overall superior. In contrast, satisfactory results were not obtained in the comparative examples. In particular, Comparative Example 8, which contained ethanol, did not exhibit any sustained moisturizing effect. Furthermore, in Comparative Examples 1 to 3, which either did not use ester oil (component A) or contained only a small amount of it, the sustained moisturizing effect after washing with soap was insufficient. In addition, in Comparative Example 4, which did not use hydrophobized hydroxyalkylcellulose (component B), the bactericidal effect was inhibited by the thickening component, and a sufficient bactericidal effect was not obtained. Furthermore, in Comparative Example 6, which did not use cationic bactericide (component C), a sufficient bactericidal effect was not obtained.

Claims

1. It contains component A: isotridecyl isononanoate, component B: hydrophobized hydroxyalkylcellulose, and component C: cationic disinfectant. It does not contain ethanol. The content of component A is 0.1 to 40% by mass, The content of component B is 0.01 to 15% by mass, The content of component C is 0.001 to 1% by mass, A disinfectant composition in the form of a cream.

2. The disinfectant composition according to claim 1, wherein when the content of component A is 1 part by mass, the content of component B is 1 / 4000 parts by mass or more and 150 parts by mass or less.

3. The disinfectant composition according to claim 1 or 2, wherein component C is benzalkonium chloride and / or benzethonium chloride.

4. A disinfectant composition according to any one of claims 1 to 3, comprising a glycerin fatty acid ester as component D.

5. The disinfectant composition according to claim 4, wherein when the content of component A is 1 part by mass, the content of component D is 1 / 4000 parts by mass or more and 150 parts by mass or less.

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