Small molecule inhibitors of NF-κB-induced kinases
JP7872322B2Active Publication Date: 2026-06-09JANSSEN PHARMA NV
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- JANSSEN PHARMA NV
- Filing Date
- 2024-08-28
- Publication Date
- 2026-06-09
AI Technical Summary
Benefits of technology
【0030】 以下の「発明を実施するための形態」から及び本発明の実践によって、本発明の更なる 実施形態、特徴、及び利点が明らかになるであろう。
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Abstract
To provide a compound that inhibits NIK and a medical composition containing such a compound as well as a use method thereof.SOLUTION: The compound of the following formula (I) is provided. In the formula, A represents a cyclopentane ring that may have a structure having a nitrogen-containing ring or a substituent, and B represents a bicyclic nitrogen-containing heterocycle. These compounds and pharmaceutical compositions are assumed to be useful for prevention or treatment of metabolic disorders such as cancers (such as B-cell malignancies including leukemia, lymphoma and myeloma), inflammatory disorders, autoimmune disorders, palmoplantar pustulosis and hidradenitis suppurativa.SELECTED DRAWING: None
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