Composition and its use

A combination of NAD precursors, NAMPT upregulators, and NQO1 upregulators in a composition addresses the limitations of NAD precursor supplementation, effectively increasing NAD levels and mitigating aging effects, including skin conditions and age-related health issues.

JP7873832B2Inactive Publication Date: 2026-06-15NUCHIDO LTD
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Patent Information

Application Number
JP2020548979
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2018-12-12
Filing Date
2019-03-13
Publication Date
2026-06-15
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Existing methods for increasing NAD levels in humans to combat aging, such as supplementation with NAD precursors like NMN and NR, face challenges including high cost, saturation effects, and diminishing efficacy over time, making it difficult to achieve substantial rejuvenation.

Method used

A composition comprising a combination of NAD precursors, NAMPT upregulators, and NQO1 upregulators, optionally with NNMT downregulators, is administered to enhance NAD concentration, utilizing a combination of active agents that can be given together or separately in various forms.

Benefits of technology

The composition effectively increases NAD levels, addressing the limitations of precursor supplementation by enhancing mitochondrial function and reducing the effects of aging, including skin conditions and age-related health issues.

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Abstract

Compositions are described that include an effective amount of a combination of two or more components selected from an NAD precursor, an NAMPT upregulator, an NQO1 upregulator, and an NNMT (nicotinamide N-methyltransferase) downregulator. [Selected Figure] Figure 1
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Citation Information

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