Method for determining the efficacy or sensitivity of anti-transferrin receptor antibodies

Intracellular iron levels serve as an indicator for determining the efficacy of anti-transferrin receptor antibodies, enabling effective treatment assessment in conditions like acute myeloid leukemia.

JP7875530B2Active Publication Date: 2026-06-18NAT UNIV CORP TOKAI NAT HIGHER EDUCATION & RES SYST +1
View PDF 9 Cites 0 Cited by

Patent Information

Application Number
JP2022555581
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2020-10-08
Filing Date
2021-10-08
Publication Date
2026-06-18
Estimated Expiration
2041-10-08

AI Technical Summary

Technical Problem

There is a lack of methods to determine the efficacy or sensitivity of anti-transferrin receptor antibodies, which are useful in treating diseases such as cancer.

Method used

Intracellular iron levels are used as an indicator to assess the efficacy or sensitivity of anti-transferrin receptor antibodies, with lower iron levels indicating higher drug efficacy.

Benefits of technology

This method allows for the determination of anti-transferrin receptor antibody efficacy, particularly in treating blood cancers like acute myeloid leukemia, by measuring intracellular iron levels.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 0007875530000004
    Figure 0007875530000004
  • Figure 0007875530000005
    Figure 0007875530000005
  • Figure 0007875530000006
    Figure 0007875530000006
Patent Text Reader

Abstract

The present invention addresses the problem of providing a method for determining the sensitivity or medicinal effect of an anti-transferrin receptor antibody. The present invention provides a method that is for determining the sensitivity or medicinal effect of an anti-human transferrin receptor antibody having an effect of inhibiting binding between human transferrin and a human transferrin receptor, and that uses the amount of intracellular iron as an index.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Methods for Evaluating the Effectiveness of Certain Cancer Treatments

    JP2006517032A

  • Osteoclast-controlling agent and method for screening the same

    JP2008303168A

  • transferrin receptor antibody

    JP2008508904A

  • Antibody capable of specifically recognizing transferrin receptor

    JP2014093958A

  • Anti-human transferrin receptor antibody and uses thereof

    US20130171061A1