Tooth surface deposit remover

Abstract

To provide a tooth surface deposit remover which is highly safe and capable of easily and effectively removing tooth surface deposits.SOLUTION: The tooth surface deposit remover contains erythritol as an active ingredient, the tooth surface deposit remover being highly safe, capable of easily and effectively removing tooth surface deposits, and a content of the erythritol preferably being 1 wt.% or more, more preferably 3 wt.% or more and 10 wt.% or less, and, when a vitamin derivative is further contained, a content of the vitamin derivative is preferably less than 7 wt.%, more preferably 0.1 wt.% or more and 5 wt.% or less, and in cases where fulvic acid is further contained, a content of the fulvic acid is preferably 0.1 wt.%.SELECTED DRAWING: Figure 2

Description

Technical Field

[0005] , , , ,

[0001] The present invention relates to a dental deposit remover that is highly safe and can easily and effectively remove dental deposits such as plaque and tartar.

Background Art

[0002] Dental deposits mainly include pellicle, plaque, tartar, materia alba, exogenous deposits, food residues, etc. In particular, two metabolites, plaque and tartar, have been reported to be importantly related to oral diseases such as periodontal disease and are closely related to the hygienic environment from the viewpoint of maintaining the oral hygienic environment.

[0003] Plaque is a general term for a structure composed of various bacteria adhering to the tooth surface and containing various components such as polysaccharides and proteins derived from the bacteria. Tartar is a general term for deposits formed by long-term deposition of plaque, which is an accumulation of oral bacteria adhering to teeth and their metabolites, without being removed, and calcified by the attachment of hydroxyapatite, whitlockite, etc.

[0004] Also, tartar has different names depending on the position where it is formed. Tartar formed above the gum margin is called supragingival tartar, and tartar formed below the gum margin is called subgingival tartar. <舍 Although tartar itself is considered to be non-pathogenic, it promotes the formation of new plaque around the formed tartar and leads to the promotion of periodontal diseases, so early removal is desired. That is, it can be said that effectively removing two deposits, plaque and tartar, is a very effective means for maintaining sound oral hygiene.

[0005] Such deposits have become a major problem in recent years, not only in humans but also in companion animals such as dogs. For example, tartar has been reported to be closely related to periodontal disease, the most common oral disease. Mild tartar can be considered an early sign of periodontal disease, while in the later stages of periodontal disease, green upper and lower tartar forms on many teeth, leading to other oral diseases such as increased bad breath and significantly worsening the overall oral disease. In other words, tartar removal is considered essential for improving oral diseases in dogs.

[0006] Typically, tartar removal involves physical action using several instruments (so-called scaling). For example, ultrasonic scalers, hand scalers for detailed work, and curettes for removing tartar from periodontal pockets are used to physically remove the tartar. [Prior art documents] [Non-patent literature]

[0007] [Non-Patent Document 1] Clinical Dental Evidence: Visual Learning of Periodontal Disease and Microbiology (Nanzando, 2007) [Non-Patent Document 2] Oral Hygiene (Issei Publishing, 2020) [Overview of the Initiative] [Problems that the invention aims to solve]

[0008] However, all of these treatments are surgical, and in most cases, they involve general anesthesia. Treatments involving general anesthesia carry risks such as renal failure, hepatic failure, hypotension, respiratory arrest, and death. For example, the rate of death due to anesthesia is reported to be approximately 0.17-0.65%, with the highest incidence occurring within 3 hours after the surgery. This is a higher rate than the rate of death due to anesthesia in humans (0.01-0.05%), indicating that removing tooth surface deposits under general anesthesia presents a significant challenge. Therefore, scaling under anesthesia is likely to be unpopular with pet owners.

[0009] Furthermore, some veterinarians do not polish the teeth after removing tartar, which can actually make it easier for plaque to accumulate due to the unevenness caused by enamel wear. Furthermore, even if scaling is performed to remove tartar, if daily dental care is not carried out, tartar will accumulate again. Furthermore, there is a concern that the jaw may be fractured during tooth extraction procedures for the treatment of periodontal disease or cavities. Thus, there are many challenges in providing dental care for companion animals.

[0010] This invention is based on these considerations and aims to provide a tooth surface deposit remover that is highly safe and can easily and effectively remove tooth surface deposits such as plaque and tartar. [Means for solving the problem]

[0011] To achieve the above objective, the tooth surface deposit remover according to claim 1 of the present invention contains erythritol as an active ingredient. It contains sodium ascorbyl phosphate. It is characterized by the following: Furthermore, the tooth surface deposit remover according to claim 2 is Claim 1 In the tooth surface deposit remover described, Contains fulvic acid It is characterized by the following: Furthermore, the tooth surface deposit remover according to claim 3 is the tooth surface deposit remover according to claim 1, The above-mentioned erythritol contains 1% by weight or more. It is characterized by the following: Furthermore, the tooth surface deposit remover according to claim 4 is the tooth surface deposit remover according to claim 3, The above-mentioned erythritol contains 3% to 10% by weight. It is characterized by the following: Furthermore, the tooth surface deposit remover according to claim 5 is as described in claim 1 In the tooth surface deposit remover described, The above contains less than 7% by weight of sodium ascorbyl phosphate. It is characterized by the following: Furthermore, the tooth surface deposit remover according to claim 6 is the tooth surface deposit remover according to claim 1, The above-mentioned sodium ascorbyl phosphate is contained in an amount of 0.1% to 5% by weight. It is characterized by the following: Furthermore, the tooth surface deposit remover according to claim 7 is the tooth surface deposit remover according to claim 2, Contains 0.1% by weight or more of the above fulvic acid. It is characterized by the following: Furthermore, the tooth surface deposit remover according to claim 8 is Claim 1~ Claim 7 one of the following In the tooth surface deposit remover described, For companion animals It is characterized by the following: Furthermore, the tooth surface deposit remover according to claim 9 is the tooth surface deposit remover according to claim 8, The companion animal mentioned above is a dog. It is characterized by the following: [Effects of the Invention]

[0012] As described above, the tooth surface deposit remover according to claim 1 of the present invention uses erythritol as an active ingredient, making it highly safe and allowing for easy and effective removal of tooth surface deposits. Furthermore, according to the tooth surface deposit remover of claim 2, the tooth surface deposit remover of claim 1 contains 1% by weight or more of erythritol, so tooth surface deposits can be removed more effectively. Furthermore, according to the tooth surface deposit remover of claim 3, the tooth surface deposit remover of claim 2 contains 3% to 10% by weight of erythritol, so tooth surface deposits can be removed more effectively. Furthermore, according to the tooth surface deposit remover of claim 4, since the tooth surface deposit remover of claim 1 contains a vitamin derivative, tooth surface deposits can be removed more effectively. Furthermore, according to the tooth surface deposit remover of claim 5, the tooth surface deposit remover of claim 4 contains less than 7% by weight of the vitamin derivative, so tooth surface deposits can be removed more effectively. Furthermore, according to the tooth surface deposit remover of claim 6, the tooth surface deposit remover of claim 5 contains 0.1% to 5% by weight of a vitamin derivative, so tooth surface deposits can be removed more effectively. Furthermore, according to the tooth surface deposit remover of claim 7, since the tooth surface deposit remover of claim 4 contains fulvic acid, tooth surface deposits can be removed more effectively. Moreover, according to the tooth surface deposit remover of claim 8, in the tooth surface deposit remover described in claim 7, since it contains 0.1% by weight of fulvic acid, tooth surface deposits can be removed more effectively. Also, the tooth surface deposit remover according to claim 9 is the tooth surface deposit remover described in any one of claims 1 to 8, and since it is for companion animals, tooth surface deposits of companion animals can be effectively removed. Furthermore, the tooth surface deposit remover according to claim 10 is the tooth surface deposit remover described in claim 9, and since the above-mentioned companion animal is a dog, tooth surface deposits of dogs can be effectively removed.

Brief Description of the Drawings

[0013] [Figure 1] Figure 1 is a photograph of a dog's teeth at the start of the formulation according to Example 2. [Figure 2] Figure 2 is a photograph of a dog's teeth after continuing the formulation according to Example 2 for 90 days.

Modes for Carrying Out the Invention

[0014] Hereinafter, an embodiment of the present invention will be described. <v The tooth surface deposit remover according to this embodiment contains erythritol as an active ingredient. The above-mentioned tooth surface deposit remover is applied to teeth and used, for example, by rubbing with a finger or a toothbrush. [

[0015] [[ID=2r9]]Preferably, the above-mentioned erythritol is contained at 1% by weight, more preferably at 3% by weight or more and 10% by weight or less. In addition, if erythritol is contained at more than 15% by weight, it will crystallize and cannot be dissolved, so it is not preferable to contain more than 10% by weight. In addition, the tooth surface deposit remover may contain erythritol and a vitamin derivative. Examples of the vitamin derivative include sodium ascorbyl phosphate (hereinafter referred to as APS). It is preferable to contain the vitamin derivative at less than 7% by weight, and more preferably, the vitamin derivative is contained at 0.1% by weight or more and 5% by weight or less. Furthermore, the tooth surface deposit remover may contain erythritol, a vitamin derivative, and fulvic acid. It is preferable that the fulvic acid is contained at 0.1% by weight. The tooth surface deposit remover of the present invention is used as an aqueous solution, and may also contain a base such as cellulose, as long as it does not impair the effects of the present invention. Furthermore, in addition to the above-mentioned base components, the tooth surface deposit remover of the present invention may appropriately contain various components that are permissible in the manufacture of pharmaceuticals and quasi-drugs, as long as they do not impair the effects of the present invention, namely, additives such as antioxidants and preservatives.

[0016] Furthermore, erythritol, vitamin derivatives, and fulvic acid are ingredients commonly found in cosmetics, health foods, and general foods on the market, making them safe and highly effective.

[0017] The following describes one embodiment in detail with reference to examples. However, the present invention is not limited to these embodiments. In the following examples, the percentages (%) indicating the concentration of reagents in the table are in weight percent. [Examples]

[0018] [Example 1] This first example involved dogs as shown in Table A. A total of 12 dogs were selected, encompassing small to large breeds. The average age was 8.3 years, with 8 males and 4 females. [Table A] The tooth deposit remover according to the present invention, as shown in the following example formulation, was filled into a pump foamer, and 1.5 to 2.0 ml (equivalent to 1 to 2 pumps of the pump foamer) was applied to the gums and teeth of the dog by hand, and the dog's teeth were brushed. This treatment was performed three times a day (morning, noon, and evening) for 90 days.

[0019] Table A also shows the concentrations of erythritol, sodium ascorbyl phosphate (APS) as a vitamin derivative, and fulvic acid in each of the above 12 dogs. The tooth surface deposit remover used in Prescription Example 1 was prepared by adding purified water to 0.1 g of erythritol and 1.4 g of cellulose as a thickening agent, so that the total amount was 100 g. The tooth surface deposit remover used in Prescription Example 2 was prepared by adding purified water to 1 g of erythritol and 1.4 g of cellulose as a thickening agent, so that the total amount was 100 g. The tooth surface deposit remover used in Prescription Example 3 was prepared by adding purified water to 3 g of erythritol and 1.4 g of cellulose as a thickening agent, so that the total amount was 100 g. The tooth surface deposit remover used in Prescription Example 4 was prepared by adding purified water to 5 g of erythritol and 1.4 g of cellulose as a thickening agent, so that the total amount was 100 g. The tooth surface deposit remover used in Prescription Example 5 was prepared by adding purified water to 7 g of erythritol and 1.4 g of cellulose as a thickening agent, so that the total amount was 100 g. The tooth surface deposit remover used in Prescription Example 6 was prepared by adding purified water to 10 g of erythritol and 1.4 g of cellulose as a thickening agent, so that the total amount was 100 g. The tooth surface deposit remover used in Prescription Example 7 was prepared by adding purified water to 5 g of erythritol, 0.01 g of APS, and 1.4 g of cellulose as a thickening agent, until the total volume reached 100 g. The tooth surface deposit remover used in formulation example 8 was prepared by adding purified water to 5 g of erythritol, 0.1 g of APS, and 1.4 g of cellulose as a thickening agent, so that the total amount was 100 g. The tooth surface deposit remover used in Prescription Example 9 was prepared by adding purified water to 5g of erythritol, 1g of APS, and 1.4g of cellulose as a thickening agent, so that the total amount was 100g. The tooth surface deposit remover used in Prescription Example 10 was prepared by adding purified water to 5g of erythritol, 5g of APS, and 1.4g of cellulose as a thickening agent, so that the total amount was 100g. The tooth surface deposit remover used in Prescription Example 11 was prepared by adding purified water to 5g of erythritol, 7g of APS, and 1.4g of cellulose as a thickening agent, so that the total amount was 100g. The tooth surface deposit remover used in Prescription Example 12 was prepared by adding purified water to 5g of erythritol, 5g of APS, 0.1g of fulvic acid, and 1.4g of cellulose as a thickening agent, so that the total amount was 100g. In addition, we used "Erythritol" manufactured by Mitsubishi Chemical Foods Corporation as erythritol, ascorbic acid PS manufactured by Showa Denko K.K. as APS, "Humicle HC" manufactured by Style & Value Japan Co., Ltd. as fulvic acid, and "Powdered Cellulose" manufactured by Sansho Co., Ltd. as cellulose.

[0020] In this Example 1, the Oral Hygiene Index (OHI) was used to quantify and evaluate the condition of plaque and calculus. The OHI is a method for quantitatively evaluating the condition of plaque and calculus. The oral cavity is divided into six sections: the maxillary right molar region, the maxillary anterior region, the maxillary left molar region, the mandibular right molar region, the mandibular anterior region, and the mandibular left molar region. Four levels of scoring are assigned to the area where plaque and calculus are attached on both the labial, buccal, and lingual sides of each of the six sections. The sum of the plaque scores is divided by the number of sections (6) to obtain the DI (Diagnosis Indication), and the sum of the calculus scores is divided by the number of sections (6) to obtain the CI (Catalog Identification Indication).

[0021] Plaque scores are evaluated based on the following criteria: No plaque or foreign deposits were observed. 0 points. Plaque covers less than one-third of the tooth surface, or any foreign deposits other than plaque are present regardless of the extent of the plaque. (1 point) Plaque covers 1 / 3 to 2 / 3 of the tooth surface (2 points) Plaque covers more than 2 / 3 of the tooth surface (3 points)

[0022] The calculus score is evaluated according to the following criteria: No tartar found: 0 points Supragingival calculus is found in an area of ​​less than one-third of the tooth surface. (1 point) Supragingival calculus is observed covering 1 / 3 to 2 / 3 of the tooth surface. Alternatively, several clumps of subgingival calculus are scattered around the cervical area. Supragingival calculus covers more than two-thirds of the tooth surface. Or, subgingival calculus is observed in a continuous band-like manner at the cervical area. (3 points)

[0023] The results for prescription example 1 are shown in Table 1, the results for prescription example 2 are shown in Table 2, the results for prescription example 3 are shown in Table 3, the results for prescription example 4 are shown in Table 4, the results for prescription example 5 are shown in Table 5, the results for prescription example 6 are shown in Table 6, the results for prescription example 7 are shown in Table 7, the results for prescription example 8 are shown in Table 8, the results for prescription example 9 are shown in Table 9, the results for prescription example 10 are shown in Table 10, and the results for prescription example 12 are shown in Table 11. Regarding prescription example 11, the prescription could not be fully administered because the dog resisted it. [Table 1] [Table 2] [Table 3] [Table 4] [Table 5] [Table 6] [Table 7] [Table 8] [Table 9] [Table 10] [Table 11]

[0024] In prescription example 1, which used a tooth surface deposit remover containing only erythritol at a concentration of 0.1% by weight, the DI before prescription was 3.5, CI was 2.0, and OHI was 5.5. After continuing the prescription for 90 days, the DI was 3.7, CI was 1.7, and OHI was 5.4. The DI after continuing the prescription for 90 days was 104.8% of the DI before prescription, the CI after continuing the prescription for 90 days was 83.3% of the CI before prescription, and the OHI after continuing the prescription for 90 days was 98.2% of the OHI before prescription. In prescription example 2, which used a tooth surface deposit remover containing only erythritol at a concentration of 1% by weight, the DI before prescription was 4.0, CI was 2.2, and OHI was 6.2. After continuing the prescription for 90 days, the DI was 2.8, CI was 1.8, and OHI was 4.7. The DI after continuing the prescription for 90 days was 70.8% of the DI before prescription, the CI after continuing the prescription for 90 days was 84.6% of the CI before prescription, and the OHI after continuing the prescription for 90 days was 75.7% of the OHI before prescription. In prescription example 3, which used a tooth surface deposit remover containing only erythritol at a concentration of 3% by weight, the DI before prescription was 3.5, CI was 1.7, and OHI was 5.2. After continuing the prescription for 90 days, the DI was 1.8, CI was 1.2, and OHI was 3.0. The DI after continuing the prescription for 90 days was 52.4% of the DI before prescription, the CI after continuing the prescription for 90 days was 70.0% of the CI before prescription, and the OHI after continuing the prescription for 90 days was 58.1% of the OHI before prescription. In prescription example 4, which used a tooth surface deposit remover containing only erythritol at a concentration of 5% by weight, the DI before prescription was 3.3, CI was 3.0, and OHI was 6.3. After continuing the prescription for 90 days, the DI was 2.0, CI was 1.8, and OHI was 3.8. The DI after continuing the prescription for 90 days was 60.0% of the DI before prescription, the CI after continuing the prescription for 90 days was 61.1% of the CI before prescription, and the OHI after continuing the prescription for 90 days was 60.5% of the OHI before prescription. In prescription example 5, which used a tooth surface deposit remover containing only erythritol at a concentration of 7% by weight, the DI before prescription was 3.2, CI was 1.8, and OHI was 5.0. After continuing the prescription for 90 days, the DI was 1.7, CI was 1.3, and OHI was 3.0. The DI after continuing the prescription for 90 days was 52.6% of the DI before prescription, the CI after continuing the prescription for 90 days was 72.7% of the CI before prescription, and the OHI after continuing the prescription for 90 days was 60.0% of the OHI before prescription. In prescription example 6, which used a tooth surface deposit remover containing only erythritol at a concentration of 10% by weight, the DI before prescription was 2.3, CI was 1.3, and OHI was 3.7. After continuing the prescription for 90 days, the DI was 1.0, CI was 1.0, and OHI was 2.0. The DI after continuing the prescription for 90 days was 42.9% of the DI before prescription, the CI after continuing the prescription for 90 days was 75.0% of the CI before prescription, and the OHI after continuing the prescription for 90 days was 54.5% of the OHI before prescription. In prescription example 7, which used a tooth surface deposit remover containing 5% by weight erythritol and 0.01% by weight APS, the DI before prescription was 2.8, CI was 2.3, and OHI was 5.2. After continuing the prescription for 90 days, the DI was 1.3, CI was 1.5, and OHI was 2.8. The DI after continuing the prescription for 90 days was 47.1% of the DI before prescription, the CI after continuing the prescription for 90 days was 64.3% of the CI before prescription, and the OHI after continuing the prescription for 90 days was 54.8% of the OHI before prescription. In prescription example 8, which used a tooth surface deposit remover containing 5% by weight erythritol and 0.1% by weight APS, the DI before prescription was 4.0, CI was 2.3, and OHI was 6.3. After continuing the prescription for 90 days, the DI was 1.3, CI was 1.2, and OHI was 2.5. The DI after continuing the prescription for 90 days was 33.3% of the DI before prescription, the CI after continuing the prescription for 90 days was 50.0% of the CI before prescription, and the OHI after continuing the prescription for 90 days was 39.5% of the OHI before prescription. In prescription example 9, which used a tooth surface deposit remover containing 5% by weight erythritol and 1% by weight APS, the DI before prescription was 3.7, CI was 1.5, and OHI was 5.2. After continuing the prescription for 90 days, the DI was 1.2, CI was 0.8, and OHI was 2.0. The DI after continuing the prescription for 90 days was 31.8% of the DI before prescription, the CI after continuing the prescription for 90 days was 55.6% of the CI before prescription, and the OHI after continuing the prescription for 90 days was 38.7% of the OHI before prescription. In prescription example 10 using a tooth surface deposit remover containing 5% by weight erythritol and 5% by weight APS, the DI before prescription was 4.5, CI was 2.8, and OHI was 7.3. After continuing the prescription for 90 days, the DI was 1.7, CI was 1.3, and OHI was 3.0. The DI after continuing the prescription for 90 days was 37.0% of the DI before prescription, the CI after continuing the prescription for 90 days was 47.1% of the CI before prescription, and the OHI after continuing the prescription for 90 days was 40.9% of the OHI before prescription. In prescription example 12, which used a tooth surface deposit remover containing 5% by weight erythritol, 5% by weight APS, and 0.1% by weight fulvic acid, the DI before prescription was 3.7, CI was 1.7, and OHI was 5.3. After continuing the prescription for 90 days, the DI was 0.7, CI was 0.7, and OHI was 1.3. The DI after continuing the prescription for 90 days was 18.2% of the DI before prescription, the CI after continuing the prescription for 90 days was 40.0% of the CI before prescription, and the OHI after continuing the prescription for 90 days was 25.0% of the OHI before prescription.

[0025] From the above results, an effect is obtained when erythritol is contained at a concentration of 1% by weight or more, and a particularly high effect is obtained at a concentration of 3% by weight or more. However, as mentioned above, if erythritol is contained at a concentration of 15% by weight or more, it crystallizes and cannot be dissolved, so it is not desirable to contain more than 10% by weight. Furthermore, when erythritol and APS (vitamin derivative) are included, a higher effect is obtained when 0.1% by weight or more of APS (vitamin derivative) is included compared to when no APS (vitamin derivative) is included. However, in formulation example 11, which contained 7% by weight of APS (vitamin derivative), the dogs disliked it due to the irritation caused by the APS (vitamin derivative), so it is preferable that the amount of APS (vitamin derivative) be less than 7% by weight, and more preferably between 0.1% by weight and 5% by weight. Furthermore, if fulvic acid is also included, a higher effect can be obtained compared to when fulvic acid is not included, and it is preferable that it be included at a concentration of 0.1% by weight or more.

[0026] [Example 2] In this Example 2, an 8-year-old female Shiba Inu was given a tooth brushing treatment using a tooth surface deposit remover for 90 days, similar to the treatment in Example 1. The tooth surface deposit remover used contained 5% by weight of erythritol and 0.1% by weight of APS. It was prepared by adding purified water to 5g of erythritol, 0.1g of APS, and 1.4g of cellulose as a thickening agent, so that the total amount was 100g. Figure 1 shows a photograph of the teeth at the start of the prescription, and Figure 2 shows a photograph of the teeth 90 days after the start of the prescription. After 90 days, tartar has been removed compared to the start of treatment. In particular, tartar on the upper molars has been significantly removed. [Industrial applicability]

[0027] The present invention relates to a tooth surface deposit remover, and more particularly to one that is highly safe and designed to remove tooth surface deposits easily and effectively, and is suitable, for example, as a tooth surface deposit remover for dogs.

Claims

1. A tooth surface deposit remover characterized by containing erythritol as an active ingredient and sodium ascorbyl phosphate.

2. In the tooth surface deposit remover according to Claim 1, A tooth surface deposit remover characterized by containing fulvic acid.

3. In the tooth surface deposit remover according to claim 1, A tooth surface deposit remover characterized by containing 1% by weight or more of the above-mentioned erythritol.

4. In the tooth surface deposit remover according to claim 3, A tooth surface deposit remover characterized by containing 3% to 10% by weight of the above-mentioned erythritol.

5. In the tooth surface deposit remover according to claim 1, A tooth surface deposit remover characterized by containing less than 7% by weight of the above-mentioned sodium ascorbyl phosphate.

6. In the tooth surface deposit remover according to claim 1, A tooth surface deposit remover characterized by containing 0.1% to 5% by weight of the above-mentioned sodium ascorbyl phosphate.

7. In the tooth surface deposit remover according to claim 2, A tooth surface deposit remover characterized by containing 0.1% by weight or more of the above-mentioned fulvic acid.

8. A tooth surface deposit remover according to any one of Claims 1 to 7, A tooth surface deposit remover characterized by being for use in companion animals.

9. In the tooth surface deposit remover according to claim 8, A tooth surface deposit remover characterized in that the companion animal mentioned above is a dog.

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