Topical skin preparations

Abstract

To provide a topical skin preparation that exhibits a high moisturizing effect when applied to the skin, and maintains the skin moisturized for an extended period.SOLUTION: A topical skin preparation comprises (A) diglycerol, (B) oil, (C) a combination of two or more nonionic surfactants with an HLB value of 13-15, (D) a polymer comprising 2-acrylamide-2-methylsulfonic acid or a salt thereof in its structure, and (E) water.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a topical skin preparation that exhibits a high moisturizing effect when applied to the skin and can maintain a moist feeling for a long period of time.

Background Art

[0002] Polyhydric alcohols are known to have excellent moisturizing functions and are used in topical skin preparations such as various cosmetics and detergents. However, when a large amount of polyhydric alcohol is formulated in a topical skin preparation to obtain a high moisturizing effect, a sticky feeling may occur after application to the skin. For this reason, there is a trade-off relationship between the moisturizing effect and the suppression of the sticky feeling, and it has been difficult to obtain a more satisfactory cosmetic.

[0003] In addition, when a topical skin preparation is applied to the skin, in addition to the components penetrating into the skin, a feeling (film feeling) as if a protective film is formed on the skin may be obtained. When such a film feeling is obtained, the moisturizing effect tends to persist, and topical skin preparations that can provide such a film feeling are also desired.

[0004] From such a background, a topical skin preparation excellent in moisturizing effect, moist feeling, skin compatibility, and refreshing feeling is desired.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Summary of the Invention

[0006] The present invention has been completed in view of the above problems, and an object thereof is to provide a topical skin preparation that quickly adapts to the skin, has little stickiness, exhibits a high moisturizing effect, and can maintain a moist feeling for a long period of time when applied to the skin.

[0007] The present invention provides the following: [1] (A) Diglycerin, (B) oil; (C) A combination of two or more nonionic surfactants with an HLB value of 13-15. (D)2-acrylamido-2-methyl propane Polymers containing sulfonic acid or its salt in their structure, and (E)Water A topical skin preparation containing [a specific ingredient]. [2] (B) A topical skin preparation according to [1], wherein component (B) is a polar oil. [3] (B) A topical skin preparation according to [1] or [2], wherein the IOB of component (B) is 0.5 or less. [4] (C) A topical skin preparation according to any one of [1] to [3], comprising a combination of polyoxyalkylene fatty acid glyceryl having an HLB value of 13 to 15 and polyoxyalkylene sorbitan fatty acid ester having an HLB value of 13 to 15. [5] (D) component is, 2-acrylamido-2-methyl propane Sulfonic acid and, One or more monomers selected from the group consisting of vinylpyrrolidone, (meth)acrylamide, sodium (meth)acrylate, hydroxyethyl (meth)acrylate, and POE(C10-18) alkyl ether (meth)acrylate, A topical skin preparation according to any of [1] to [4], which is a copolymer of [1]. [6] Based on the total mass of the aforementioned topical skin preparation, (A) The content of component is 5 to 14% by mass. A topical skin preparation as described in any of [1] to [5]. [7] Based on the total mass of the aforementioned topical skin preparation, (B) The content of component is 0.03 to 11.5% by mass. A topical skin preparation as described in any of [1] to [6]. [8] Based on the total mass of the topical skin preparation, the content rate of component (C) is 0.26 to 3% by mass, and it is the topical skin preparation according to any one of [1] to [7]. [9] Based on the total mass of the topical skin preparation, the content rate of component (D) is 0.3 to 1.8% by mass, and it is the topical skin preparation according to any one of [1] to [8].

[10] The ratio of [(content of component (D))] / [(content of component (A))] is 0.02 to 0.16, and it is the topical skin preparation according to any one of [1] to [9].

[11] Component (B) is a combination of a polar oil and a non-polar oil, and it is the topical skin preparation according to any one of [1] to

[10] .

[12] It further contains a polyhydric alcohol other than (F) diglycerin, and it is the topical skin preparation according to any one of [​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​The external preparation for skin according to the present invention contains diglycerin (hereinafter sometimes referred to as component (A)). Diglycerin has a structure in which two glycerins are dehydrated and condensed and is a polyhydric alcohol having four hydroxyl groups. Diglycerin is used in the fields of cosmetics, quasi-drugs, etc., and can be arbitrarily selected from them in the present invention.

[0010] Diglycerin is one of the polyhydric alcohols and is known to have a moisturizing function. However, in the external preparation for skin of the present invention, diglycerin, in combination with the components described later, exhibits an excellent moisturizing function and further exhibits an effect of improving the moist feeling and the film feeling without worsening the sticky feeling.

[0011] In the external preparation for skin according to the present invention, the content of diglycerin can be arbitrarily adjusted according to the required characteristics and the use of the external preparation for skin. However, the content of component (A) is preferably 5 to 14% by mass, more preferably 6 to 13% by mass, based on the total mass of the external preparation for skin. [(B) Oil] The external preparation for skin according to the present invention contains an oil (hereinafter sometimes referred to as component (B)). The oil may be either a polar oil or a non-polar oil.

[0012] Examples of the polar oil include ester oils and some higher fatty acids, and ester oils are particularly preferred. Among the polar oils, those having an IOB value of 0.5 or less are preferred, and those having an IOB value of 0.4 or less are more preferred.

[0013] Here, the IOB value is an abbreviation for Inorganic / Organic Balance, and it is a value that represents the ratio of inorganic value to organic value, and serves as an indicator of the degree of polarity of an organic compound. Specifically, the IOB value is expressed as IOB value = inorganic value / organic value. For each of the "inorganic value" and "organic value," for example, one carbon atom in a molecule has an "organic value" of 20, and one hydroxyl group has an "inorganic value" of 100. The "inorganic value" and "organic value" are set according to each atom or functional group, and the IOB value of an organic compound can be calculated by summing the "inorganic value" and "organic value" of all atoms and functional groups in the organic compound (see, for example, Yoshio Koda, "Organic Concept Diagram - Fundamentals and Applications," pp. 11-17, Sankyo Publishing, 1984).

[0014] The following are examples of polar oils that can be used in the topical skin preparation according to the present invention. Oleic acid (IOB value = 0.42), Isostearic acid (IOB value = 0.43), Isopropyl myristate (IOB value = 0.18), Octyl palmitate (IOB value = 0.13), Isopropyl palmitate (IOB value = 0.16), Butyl stearate (IOB value = 0.14), Hexyl laurate (IOB value = 0.17), Myristyl myristate (IOB value = 0.11), Decyl oleate (IOB value = 0.11), Isononyl isononanoate (IOB value = 0.20), Isotridecyl isononanoate (IOB value = 0.15), Cetyl ethylhexanoate (IOB value = 0.13), Pentaerythrityl tetraethylhexanoate (IOB value = 0.35), Diethylhexyl succinate (IOB value = 0.32), Glycol distearate (IOB value = 0.16), Glyceryl diisostearate (IOB value = 0.29), Neopentyl glycol dicaprate (IOB value = 0.25), diisostearyl malate (IOB value = 0.28), Trimethylolpropane triisostearate (IOB value = 0.16), Glyceryl tri-2-ethylhexanoate (triethylhexanoin) (IOB value = 0.35), Trimethylolpropane trioctanoate (IOB value = 0.33), Trimethylolpropane triisostearate (IOB value = 0.16), Diisobutyl adipate (IOB value = 0.46), N-lauroyl-L-glutamic acid-2-octyldodecyl ester (IOB value = 0.29), 2-hexyldecyl adipic acid (IOB value = 0.16), Diisopropyl sebacate (IOB value = 0.40), Octyl methoxycinnamate (IOB value = 0.28), Olive oil (IOB value = 0.16), Castor oil (IOB value = 0.43), Decyltetradecanol (IOB value = 0.21), Octyldodecanol (IOB value = 0.26), Oleyl alcohol (IOB value = 0.28), 2-ethylhexyl palmitate (IOB value = 0.13), 2-ethylhexyl ethylhexanoate (IOB value = 0.2), Triisostearin (IOB value = 0.16), Tripropylene glycol dipivalate (sometimes referred to as "PPG-3 dipivalate") (IOB value = 0.52), Octyl salicylate (IOB=0.60), Caprylic / capric triglyceride (IOB value = 0.33) These include the following. Of these, cetyl ethylhexanoate (IOB value = 0.13), octyl palmitate (IOB value = 0.13), or tri(caprylic / capric acid) glyceryl (IOB value = 0.33) are particularly preferred. These polar oils can be used alone or in combination of two or more.

[0015] The topical skin preparation according to the present invention may contain a non-polar oil as component (B). However, in the present invention, when component (B) contains a non-polar oil, it is preferable to use a combination of a polar oil and a non-polar oil.

[0016] Any nonpolar oil can be used as such, but examples include isododecane, dimethicone, hydrogenated polydecene, mineral oil, undecane, tridecane, hydrogenated polyisobutene, isohexadecane, hydrogenated polyisobutene, petrolatum, squalane, silicone oil, diphenyl dimethicone, phenyl trimethicone, trimethylpentaphenyltrisiloxane, diphenylsiloxyphenyl trimethicone, methicone, hydrogen dimethicone, caprylyl methicone, and PCA dimethicone. One or more nonpolar oils selected from this group can be used in combination.

[0017] In the topical skin preparation according to the present invention, the content of component (B) is preferably 0.03 to 11.5% by mass, and more preferably 0.05 to 10% by mass, based on the total mass of the topical skin preparation.

[0018] [(C) Nonionic surfactant] The topical skin preparation according to the present invention comprises a nonionic surfactant (hereinafter sometimes referred to as component (C)). In the present invention, component (C) is a combination of two or more different types of nonionic surfactants. Here, a combination of different types of nonionic surfactants refers to a combination of nonionic surfactants with different basic structures, not, for example, different hydrocarbon chain lengths or saponification values. Examples of nonionic surfactants include glycerin fatty acid esters, sorbitan fatty acid esters, sucrose fatty acid esters, polyoxyalkylene alkyl ethers, polyoxyalkylene alkylphenyl ethers, fatty acid alkanolamides, lecithin, and saponins. If only one type of nonionic surfactant is used, sufficient effects may not be obtained. By using a combination of surfactants, sufficient emulsification performance can be ensured, and the speed at which the topical skin preparation is absorbed into the skin can be adjusted.

[0019] The topical skin preparation according to the present invention may use two or more of these selected types, but a combination of polyoxyalkylene fatty acid glyceryl, which is one of the glycerin fatty acid esters, and polyoxyalkylene sorbitan fatty acid ester, which is one of the sorbitan fatty acid esters, is preferred.

[0020] Examples of polyoxyalkylene fatty acid glyceryls include POE-monoleates such as POE-glycerin monostearate, POE-glycerin monoisostearate, and POE-glycerin triisostearate, while examples of polyoxyalkylene sorbitan fatty acid esters include POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, and POE-sorbitan tetraoleate.

[0021] The mass mixing ratio of the two types of nonionic surfactants is preferably in the range of 1:9 to 9:1, however, the range in which the effect is strongest varies depending on the type of surfactant. For example, when using polyoxyalkylene fatty acid glyceryl and polyoxyalkylene sorbitan fatty acid ester, the mass mixing ratio is preferably 2:8 to 4:6.

[0022] Furthermore, it is preferable that the HLB of each nonionic surfactant is between 13 and 15. When the HLB is within this range, the transparency of the appearance of the topical skin preparation increases, and the texture of the composition improves.

[0023] In the topical skin preparation according to the present invention, the content of component (C) is preferably 0.26 to 3.0% by mass, and more preferably 0.3 to 2.0% by mass, based on the total mass of the topical skin preparation. Here, the content is the total content of the nonionic surfactant.

[0024] [(D)2-acrylamido-2-methyl propane Polymers containing sulfonic acid or its salt in their structure. The topical skin preparation according to the present invention comprises a specific polymer (hereinafter sometimes referred to as component (D)). Component (D) is 2-acrylamido-2-methyl propane It contains sulfonic acid (also called "acryloyldimethyltaurate," hereafter sometimes referred to as AMPS) or a salt thereof in its structure. Component (D) is thought to provide the effect of quickly absorbing topical skin preparations into the skin, maintaining a moist feeling for a long period of time, and further providing a film-like effect. These improving effects are thought to be brought about by the AMPS-derived structure contained in the polymer, and the shape of the main structure of the polymer is not particularly limited. However, from the standpoint of availability and the safety of topical skin preparations, (i) 2-acrylamido-2-methyls propaneIt is preferable that the copolymer is a copolymer of (ii) lactic acid and one or more monomers selected from the group consisting of vinylpyrrolidone, (meth)acrylamide, sodium (meth)acrylate, hydroxyethyl (meth)acrylate, and POE(C10-18) alkyl ether (meth)acrylate. This copolymer may also contain other monomers as long as they do not impair the effects of the present invention.

[0025] Examples of such polymers include AMPS(salt) homopolymers, AMPS(salt) / vinylpyrrolidone copolymers, AMPS(salt) / dimethyl(meth)acrylamide copolymers, AMPS(salt) / (meth)acrylamide copolymers, AMPS(salt) / sodium(meth)acrylate copolymers, and AMPS(salt) / POE(C) 10-18 Examples include alkyl ether (meth)acrylate copolymers. In the present invention, among others, AMPS (salt) / vinylpyrrolidone copolymers and AMPS / POE(C 10-18 )Alkyl ether (meth)acrylate copolymer, AMPS (salt) / (meth)acrylate sodium copolymer, etc. are preferably used, and here POE(C 10-18 )As alkyl ether (meth)acrylates, POE behenyl ether methacrylate, POE stearyl ether methacrylate, etc. are preferably used. These copolymers may or may not be crosslinked.

[0026] (D) Preferred specific examples of component are: (Acryloyldimethyltaurate ammonium / vinylpyrrolidone) copolymer, (Acryloyldimethyltaurate Ammonium / Beheneth-25 Methacrylate) Crosspolymer, (Acryloyldimethyltaurate Ammonium / Steareth-25 Methacrylate) Crosspolymer These are some examples.

[0027] The above (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer is sold as "Aristoflex AVC" (manufactured by Clariant), etc. The above (Acryloyldimethyltaurate Ammonium / Beheneth-25 Methacrylate) Crosspolymer is sold as "Aristoflex HMB" (manufactured by Clariant), etc. The above (Acryloyldimethyltaurate Ammonium / Steareth-25 Methacrylate) crosspolymer is sold as "Aristoflex HMS" (manufactured by Clariant), etc. Each of these is commercially available and can be used suitably. Component (C) can be used individually or in combination of two or more.

[0028] In the topical skin preparation according to the present invention, the content of component (D) is preferably 0.3 to 1.8% by mass, and more preferably 0.5 to 1.75% by mass, based on the total mass of the topical skin preparation.

[0029] Furthermore, while the effects of the present invention are thought to be obtained by the combination of each component, the effects of the present invention tend to be particularly pronounced when the ratio of [content of component (D)] / [content of component (A)] is between 0.02 and 0.16, so it is preferable to keep it within this range.

[0030] [(E)Wed] The topical skin preparation according to the present invention further contains water in addition to the above-mentioned components. As the water, water used in cosmetics, quasi-drugs, etc., can be used, for example, purified water, ion-exchanged water, tap water, etc.

[0031] [Other ingredients] In addition to the above-mentioned components (A) to (E), the topical skin preparation according to the present invention may contain other components as needed, to the extent that they do not impair the effects of the present invention.

[0032] One such other component is a polyhydric alcohol (hereinafter sometimes referred to as component (F)). Here, component (F) in the present invention is different from diglycerin, which is component (A). Component (F) primarily provides a moisturizing effect in the topical skin preparation according to the present invention. When the topical skin preparation according to the present invention is applied to hand creams, skin creams, etc., a high moisturizing effect is advantageous. Examples of such polyhydric alcohols include glycerin, 1,3-butylene glycol, ethylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol-polypropylene glycol, trimethylolethane, trimethylolpropane, erythritol, pentaerythritol, sorbitan, glucose, sorbitol, maltitol, sucrose, raffinose, hexylene glycol, 1,2-pentanediol, and trehalose.

[0033] When the topical skin preparation according to the present invention contains component (F), the content of component (F) can be 5 to 14% by mass, and preferably 7 to 14% by mass, based on the total mass of the topical skin preparation.

[0034] The topical skin preparation according to the present invention may contain ingredients commonly used in topical skin preparations other than those described above. Examples of such other ingredients include powder components, higher alcohols, higher fatty acids, cationic surfactants, amphoteric surfactants, humectants other than polyhydric alcohols, water-soluble polymers, film-forming agents, UV absorbers, metal ion chelating agents, lower alcohols, sugars, amino acids, organic amines, polymer emulsions, pH adjusters, skin nutrients, vitamins, antioxidants, antioxidant aids, fragrances, and the like.

[0035] The dosage form of the topical skin preparation according to the present invention is not particularly limited and may be either a non-emulsified or emulsified preparation. Furthermore, if an emulsified preparation is used, it may be either an oil-in-water emulsion or a water-in-oil emulsion. However, an oil-in-water emulsion is preferred for its superior feel. Additionally, any dosage form such as a liquid, emulsion, or cream can be used. [Examples]

[0036] The present invention will be described below using various examples. However, the present invention is not limited in any way by these examples. Furthermore, unless otherwise specified, the content is expressed as mass % relative to the total amount.

[0037] [Examples 1-12 and Comparative Examples 1-11] Topical skin preparations were prepared by blending each component to achieve the concentrations shown in Tables 1 and 2.

[0038] Evaluation method Five expert panel members were selected, all women in their 30s and 40s who had received training in sensory evaluation and were capable of evaluating according to certain standards. These five expert panel members applied each topical skin preparation to their skin. (a) Speed ​​of absorption during application, (b) Moisturizing feeling after application, (c) No stickiness after application, (d) Film feel after application, and (e) The duration of the moisturizing effect after application We evaluated the user experience for each item. The evaluation criteria for each item was a 7-point scale from A (excellent) to G (very bad). A rating of A to D for each item was considered a passing grade.

[0039] [Table 1] *1: KF-96L-1.5CS (product name, manufactured by Shin-Etsu Chemical Co., Ltd.) *2: KF-96A-6T (product name, manufactured by Shin-Etsu Chemical Co., Ltd.)

[0040] Table 2

Claims

1. (A) Diglycerin, (B) oil; (C) A combination of two or more nonionic surfactants with an HLB value of 13 to 15. (D) Polymers containing 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof in their structure, (E) Water A topical skin preparation comprising: (C) Component contains a combination of polyoxyalkylene fatty acid glyceryl with an HLB value of 13-15 and polyoxyalkylene sorbitan fatty acid ester with an HLB value of 13-15. Based on the total mass of the aforementioned topical skin preparation, (A) The content of component is 5 to 14% by mass. (B) The content of component is 0.03 to 11.5% by mass. (C) The content of component is 0.26 to 3% by mass. (D) The content of component is 0.3 to 1.8% by mass. It is a topical skin preparation.

2. (B) The topical skin preparation according to claim 1, wherein component (B) is a polar oil.

3. (B) The topical skin preparation according to claim 1 or 2, wherein the IOB of component (B) is 0.5 or less.

4. (D) Component is 2-acrylamido-2-methylpropanesulfonic acid and One or more monomers selected from the group consisting of vinylpyrrolidone, (meth)acrylamide, sodium (meth)acrylate, hydroxyethyl (meth)acrylate, and POE (C10-18) alkyl ether (meth)acrylate, A topical skin preparation according to claim 1 or 2, wherein the copolymer is a copolymer of the following.

5. A topical skin preparation according to claim 1 or 2, wherein the ratio of [content of component (D)] / [content of component (A)] is 0.02 to 0.

16.

6. (B) The topical skin preparation according to claim 1 or 2, wherein component (B) is a combination of a polar oil and a non-polar oil.

7. (F) The topical skin preparation according to claim 1 or 2, further comprising a polyhydric alcohol other than diglycerin.

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