Apparatus and method for volatilizing aqueous solution

Abstract

In aerosol spraying, the size, velocity, and duration of volatilization of the aerosol produced are controlled without boiling the liquid composition. The present invention relates to an apparatus (1) adapted to volatilize a viscous liquid composition (S) into microdroplets (5) of a volatilization element upstream of a preheating chamber (12), as well as to a method for providing an aerosol from the liquid composition, an aqueous liquid composition used to produce the aerosol, and a kit comprising the same.

Description

Technical Field

[0001] The present invention relates to vaporization devices such as electronic cigarettes and inhalers. In particular, the device according to the present invention is adapted to vaporize aqueous solutions with improved efficiency. It enables the generation of micro-droplets having an average diameter smaller than about 4 μm, preferably on the order of 1 μm. The present disclosure further relates to a process step of vaporizing an aqueous solution in an aerosol of such droplets. It also relates to a kit comprising the device and at least one aqueous solution, separately packaged.

Background Art

[0002] It is known that the average size of droplets is an important variable for the efficiency of inhaled substances. Generally, micro-droplets of about 4 μm are considered optimal for inhalation into the lungs. Whether the substance or the solution in which it is dissolved relates to pharmaceuticals or to tobacco derivatives such as nicotine, it is preferable to produce an aerosol having a homogeneous particle size with a diameter smaller than about 4 μm.

[0003] For reasons of stability and homogeneity, the substances used for inhalation are often combined with additives and organic solvents. When intended for vaporization, such water-insoluble solvents usually have a low natural viscosity and are thus advantageous for the generation of micro-droplets of a low size. However, additives and organic solvents can have several adverse effects. In addition to potential undesirable interactions with living organisms, such non-aqueous solutions can give rise to irritation, bad taste, or other harmful sensations once inhaled or during inhalation. Therefore, aqueous solutions are desirable for inhalation. Since water inherently has a lower viscosity than organic solvents, it is difficult to produce an aerosol having a required average particle size of 4 μm or less.

[0004] Patent Document 1 describes an apparatus for heating a substance in a solution until it vaporizes. However, due to the high enthalpy of vaporization of water, this method appears unsuitable for aqueous solutions because it requires a large local energy supply for the vaporization of the solvent. As a result, energy consumption increases, and the cycle time for vaporization lengthens. Furthermore, high temperatures can degrade the substances in the composition or trigger undesirable chemical reactions in the mixture.

[0005] Patent document 2 describes an apparatus that uses a piezoelectric mesh to volatilize an aerosol precursor in order to avoid side effects caused by heat treatment. While compositions based on organic solvents can be volatilized, such an arrangement does not appear to be directly applicable to aqueous solutions. In particular, it is not optimal for controlling the average droplet size of aqueous compositions. In addition, the piezoelectric mesh requires an electrical boost for the vaporization of the solution, which limits the autonomy of the apparatus when it is powered by batteries. [Prior art documents] [Patent Documents]

[0006] [Patent Document 1] International Publication No. 95 / 01137 [Patent Document 2] U.S. Patent Application Publication No. 2019 / 014819 [Overview of the project] [Problems that the invention aims to solve]

[0007] Therefore, an object of the present invention is to provide a device that enables the spraying of aqueous solutions with controlled droplet sizes. In particular, an object of the present invention is to provide a device that enables the spraying of aqueous solutions with aerosol droplets having an average diameter of less than 4 μm or on the order of 1 μm or less.

[0008] The objective is also to provide a device that can reduce the viscosity of a liquid composition to less than 1 cP and improve the flow rate of the resulting aerosol.

[0009] Another objective of the present invention is to provide a device that can volatilize substances in an aqueous solution without combustion or decomposition. Therefore, the objective is to volatilize the aqueous solution without boiling it.

[0010] Another object of this disclosure is to provide a process for vaporizing an aqueous solution into aerosol droplets having a controlled average size. More specifically, vaporizing an aqueous solution while controlling the average size of the particles.

[0011] Another object of the present invention is to provide an apparatus suitable for volatilizing an aqueous solution, which can adjust the temperature, the size of the released droplets, or the duration of volatilization.

[0012] A further objective is to provide an aqueous solution containing at least one substance having a biological effect, the aqueous solution having a viscosity greater than about 2, 1.5, or 1.4 cP at room temperature (20°C). More specifically, an objective is to provide a solution containing less organic solvent than known solutions, or containing no organic solvent, or substantially no organic solvent. An objective is to provide a liquid solution for inhalation containing less than 30%, or less than 25%, or less than 20% organic solvent. [Means for solving the problem]

[0013] These objectives are achieved by the means of the present invention, which are described in the independent claims and in more detail in the dependent claims.

[0014] The claimed solution addresses the aforementioned disadvantages. In particular, it enables the diffusion of minute droplets of aqueous solution with a controlled average diameter. Furthermore, it improves the efficiency of producing aerosols that are free from or substantially free of undesirable additives or solvents. Moreover, it allows for the volatilization of substances with minimal energy consumption. Thus, the claimed apparatus has longer autonomy and exhibits improved user comfort. It is also possible to control the user's taste variables through flavor enhancer assays and control the heat through the temperature of the post-heating section.

[0015] An example of the invention described above will be illustrated with the following drawings. [Brief explanation of the drawing]

[0016] [Figure 1] Figure 1 is a schematic diagram of the apparatus according to the present invention. [Figure 2] Figure 2 shows details of the preheating chamber of the apparatus according to the present invention. [Figure 3] Figure 3 is a schematic diagram of the commands for the device according to the present invention. [Figure 4a] This is a cross-sectional view of the apparatus described in this application according to one embodiment. [Figure 4b] This is a cross-sectional view of the apparatus described in this application according to one embodiment. [Figure 5a] This is a cross-sectional view of the apparatus described in this application according to one embodiment. [Figure 5b] This is a cross-sectional view of the apparatus described in this application according to one embodiment. [Modes for carrying out the invention]

[0017] The device 1 of the present disclosure includes a housing 10 having a storage compartment 11. The storage compartment 11 can be the internal space of the housing 10, for example, the internal space at the end of the housing 10. To access (communicate with) the storage compartment 11, the housing 10 includes a removable part such as a cap or lid that can be screwed or clipped to the end of the housing 10. Alternatively, a part of the housing 10 can be separated from the other parts of the device to open access to the storage compartment 11. Such a removable part can represent a part of the device, such as 10% or 20% of its length. For example, it can be screwed to the remaining part of the housing 10 representing the main body of the device 1. Alternatively, the storage compartment 11 can be a central compartment of the device that is accessible through an openable side lid. Such a side lid can be connected to the housing 10 via one or more hinges.

[0018] The storage compartment 11 can be adapted to receive the liquid composition S from an external tank. An appropriate sealing part is arranged at the connection between the lid and the housing 10 to avoid leakage. In one embodiment, the housing 10 includes at least a transparent part such as a side window at the height of the storage compartment 11 so that the user can see the level of the liquid composition S remaining in the storage compartment 11. Accordingly, the housing part corresponding to the storage compartment 11 can be completely transparent, or transparent in a part of its surface, for example, half of its surface. Alternatively, only the lid covering the storage compartment 11 is transparent.

[0019] In another embodiment, the storage compartment 11 may be adapted to receive the liquid composition S. Such a cartridge has an internal volume adapted to store a liquid formulation and a connection adapted to couple the cartridge to the device 1. The connection may include a sealing means to prevent leakage of the liquid composition S when the cartridge is separated from the device 1. In addition, it may include fixing means such as threads or one or more lugs adapted to maintain the cartridge connected to the device 1. The sealing means of the cartridge is preferably adapted to open automatically when the cartridge is connected to the device 1. For this purpose, at the connection point of the cartridge, the end of the pipeline may be provided on the device 1 so that the sealing means of the cartridge can be perforated or opened when connecting the cartridge to the device 1. When the storage compartment 11 is adapted to receive the cartridge, it may be without a lid or cap and be directly connected to the housing 10 without requiring many operations. Alternatively, a cap may be provided to protect at least the connection part of the device 1. When there is a cap, the cap may be adapted to act on the cartridge with the force required for perforating or opening the sealing means when connecting to the device 1. Here, it should be understood that any suitable arrangement may be adapted to the present device 1.

[0020] The storage compartment 11 includes at least one solution inlet 110 that allows the liquid composition S to flow from the storage compartment 11 into the preheating chamber 12. The solution inlet 110 may be a through hole or a plurality of through holes that allow the liquid composition S to freely flow into the preheating chamber 12. However, such an arrangement is susceptible to the influence of gravity and the number of positions that the device 1 can take under the usage conditions may be limited. The solution inlet 110 may include a movable part that can be opened and closed as required. For example, the preheating chamber 12 may have a predetermined volume corresponding to the dosage of the solution S to be inhaled. By opening the solution inlet 110, the preheating chamber 12 can be filled with an appropriate amount of the liquid composition S. By closing the solution inlet 110 before starting inhalation, it is ensured that excessive inhalation of the composition S is prevented.

[0021] Alternatively, the solution inlet 110 may have one or more holes of limited size through which the liquid composition S can flow in by capillary action. The size and number of holes may be adapted to the viscosity of the liquid composition S. In one preferred configuration, the diameter of the holes is adjusted to prevent or substantially prevent the passage of liquids with viscosities higher than about 3 cP, 5 cP, or 10 cP. Alternatively or additionally, the size of the holes is adjusted to allow or substantially allow the movement of liquid compositions by capillary action with viscosities lower than about 2 cP, lower than about 1.5 cP, or even lower than 1 cP. In one preferred configuration, the size of the holes is calibrated so that the movement of liquid compositions with viscosities lower than 1 cP by capillary action is 2, 3, or 4 times faster, or substantially faster, than the movement of liquid compositions with viscosities higher than 3 cP or 4 cP. Alternatively, one or more of the holes in the solution inlet 110 may be larger to allow the liquid composition S to pass freely regardless of its viscosity, and may be provided with a cotton core adapted to absorb the liquid composition S by capillary action.

[0022] Apparatus 1 of the present disclosure comprises a preheating chamber 12 downstream of a storage compartment 11. The preheating chamber 12 comprises at least one heating device 120 or is in direct contact with at least one heating device 120. Such heating device may be an electrical resistor or any associated device adapted to supply some heat. The heating device 120 may be positioned within the preheating chamber 12 in direct contact with the liquid composition S. This allows for very efficient and rapid local heating of the liquid composition 1 surrounding the heating device 120. The heating device 120 may be positioned near the solution inlet 110 so that the liquid composition S is already warmed when it flows into the preheating chamber 12. Alternatively, the heating device 120 may be positioned downstream, closer to the volatile elements, so that the liquid composition S is locally warmed just before it is diffused as minute droplets 5 by the volatile elements.

[0023] The heating device 120 may be enclosed in a protective housing that is immersed in the liquid composition S in the preheating chamber 12. Such a protective housing may be made of a thermally conductive material such as stainless steel, aluminum, or a metal similar to a metallic element. The protective housing may further include an extension that allows for temperature uniformity throughout the volume of the preheating chamber 12. Alternatively, the protective housing may be in contact with one or more walls of the preheating chamber 12. Alternatively, the heating device 120 may be integrated into one or more walls of the preheating chamber 12, such as a side wall, a wall separating the storage compartment 11 from the preheating chamber 12, or a wall separating the preheating chamber 12 from the aerosol chamber 13.

[0024] In one embodiment, the heating device 120 is integrated into the solution inlet 110 so that the liquid composition S enters the preheating chamber at an appropriate temperature.

[0025] In another embodiment, the heating device 120 is integrated into the downstream wall of the preheating chamber 12 so that the heating energy is supplied at or near the volatilization point of the liquid composition S.

[0026] In one embodiment, as clearly shown in Figure 2, the preheating chamber 12 comprises a plurality of capillaries 12a, 12b, one end of which is fluidly connected to a solution inlet 110 and the other end of which is fluidly connected to a volatile element. The inner diameter of the capillaries 12a, 12b may be several hundred μm. The capillaries 12a, 12b may be provided with inner diameters between approximately 100 μm and approximately 800 μm, or between approximately 200 μm and approximately 600 μm, for example. The inner diameter of the capillaries 12a, 12b may decrease along the length from the solution inlet 110 to the volatile element. This allows control of the flow along the capillaries according to the viscosity of the liquid composition S. The inner diameter of the capillaries 12a, 12b can then be reduced from one end to the other by a value between 10% and 50%, for example, between approximately 20% or 30%. One or more heating devices 120 may surround the capillaries 12a, 12b. The heating devices 120 may be in direct contact with the capillaries for rapid and efficient temperature control. The heating devices 120 may be located away from the walls of the capillaries to allow for smooth temperature changes that prevent localized combustion of components of the liquid composition S or localized boiling or pressure rise of the liquid composition S. The combination of the heating devices 120 and capillaries having either a constant or decreasing inner diameter allows for control of the rate at which the liquid composition S flows, thereby affecting its debit (amount used in one application).

[0027] The heating device 120 is adapted to heat the liquid composition S to a temperature that prevents boiling, combustion of its components, side reactions, or chemical decomposition. Therefore, the liquid composition S is preferably heated between approximately 30°C and 90°C, preferably below 80°C or 60°C. Temperatures between approximately 40°C and 60°C appear suitable for most of the liquid compositions S envisioned in the apparatus 1. In another embodiment, the heating device 120 is controlled to impart a suitable viscosity to the liquid composition S. The viscosity of liquid solutions S, particularly aqueous solutions, is usually too high at 20°C to provide at least one of sufficiently small droplets and adequate dew. Furthermore, the apparatus 1 may be used at very low temperatures during outdoor use, especially in winter, which naturally significantly increases the viscosity of the liquid composition. Therefore, the heating device 120 helps to adjust and reproduce the appropriate viscosity with minimal energy consumption.

[0028] The capillaries 12a and 12b are emphasized for enabling rapid temperature exchange and providing immediate control of at least one of the debite and temperature of the liquid solution in the preheating chamber 12. It is also emphasized that the length of the capillaries 12a and 12b traversing the preheating chamber 12 also affects the temperature control of the liquid composition S. The capillaries 12a and 12b may have a linear shape from the solution inlet 110 toward the volatile elements. For better temperature control, the capillaries 12a and 12b may represent longer paths within the preheating chamber 12 by having a non-linear shape. The capillaries 12a and 12b can take any suitable meandering path, for example, having a coil shape, being equipped with baffles, or enabling efficient temperature exchange with the heating device 12.

[0029] In one embodiment, the internal volume of the preheating chamber 12 is provided with a porous material that can contain and discharge the liquid composition S. The heating device 12 may be arranged as described above, or it may be placed inside the porous material containing the liquid composition S. The porous material can thus be maintained at a suitable temperature. Such a porous material may be in direct contact with volatile elements.

[0030] Apparatus 1 according to the present disclosure further comprises a volatile element adapted to spread microdroplets 5 from a liquid composition S present in the preheating chamber 12 toward an aerosol chamber 13 downstream of the preheating chamber 12. The volatile element comprises at least one mesh 14 through which the liquid composition S can pass while forming microdroplets 5. The pores of the mesh 14 preferably have diameters between 0.5 micrometers and several micrometers, such as 3 to 10 micrometers. The mesh 14 may extend through the entire surface between the preheating chamber 12 and the aerosol chamber 13, and thus exhibit homogeneous porosity across the entire surface. Such an arrangement appears to be advantageous when the surface between the preheating chamber 12 and the aerosol chamber 13 is in complete or substantially complete contact with the liquid composition S, such as when the volume of the preheating chamber 12 is filled with the liquid composition S, or when a porous material is in contact with the mesh 14.

[0031] Alternatively, several meshes 14a and 14b can be placed on the surface separating the preheating chamber 12 from the aerosol chamber 13, forming a single passage for the liquid composition S to pass through to the aerosol chamber 13. Such a configuration is advantageous in combination with the capillaries 12a and 12b described above. The ends of the capillaries 12a and 12b coincide with the corresponding meshes 14. The liquid composition S flowing continuously through the capillaries reaches the meshes 14 in direct contact and can diffuse into the aerosol chamber 13 as microdroplets 5. The number and size of such meshes depend on the need.

[0032] The mesh 14 may be integrated with or combined with the vibration actuator, regardless of whether it is a unique mesh covering the surface between the preheating chamber 12 and the aerosol chamber 13, or equivalent to a plurality of smaller meshes. For example, the mesh 14 may be integrated with a flexible membrane combined with the vibration actuator. The vibration frequencies provided by the vibration actuator are provided between approximately 50 kHz and 150 kHz. Preferably, the vibration frequencies provided by the vibration actuator are provided between 80 kHz and 130 kHz, more preferably between 100 kHz and 120 kHz.

[0033] The mesh 14, or the number of holes in the mesh, is provided between 500 and 5000, preferably between 800 and 2000. The number of holes spreading across the surface between the preheating chamber 12 and the aerosol chamber 13 is, for example, about 1000.

[0034] Alternatively, an outlet equipped with a vibrating actuator may be positioned upstream of the mesh 14 to actively guide the liquid composition S from the preheating chamber through the mesh 14 toward the aerosol chamber 13. Such a vibrating outlet is associated with a pump. The vibration frequency in this configuration is higher than 500 kHz. The vibration frequency may be, for example, between approximately 500 kHz and 1500 kHz, or between approximately 500 kHz and 1000 kHz.

[0035] Furthermore, the mesh 14 may comprise multiple layers of porous material, either combined together or separated by gaps. The layers of porous material may have different pore sizes. The pore size of the first layer, located upstream of the liquid path, can be larger than that of the last layer, located downstream. Fragmentation of the liquid can proceed along the path, reducing the energy required to volatilize the liquid composition. This allows for a reduction in vibration frequency.

[0036] The mesh 14 according to this disclosure may, alternatively or additionally, comprise non-planar portions of porous material to increase the contact surface with the liquid composition S. The mesh 14 may have a three-dimensional shape. It may comprise, for example, a folded sheet.

[0037] The tubes, preheating chambers, vibrating mesh chambers, and meshes according to this disclosure may, alternatively or additionally, be provided with smooth surfaces that limit or avoid the accumulation of residues. Furthermore, they may be coated with hydrophobic materials, anti-adhesion materials, or other materials that limit the adhesion of residues. Alternatively, the surfaces may be coated with silver, which exhibits a situ bactericidal effect.

[0038] The vibration actuator can be any device capable of vibrating the mesh 14 at an appropriate frequency. For example, it can be a piezoelectric actuator, a piezoelectric magnetic actuator, or a related device. Furthermore, multiple identical or different vibration actuators may be arranged in parallel.

[0039] Downstream of the volatile element is an aerosol chamber 13 into which the fine droplets 5 ejected from the volatile element are dispersed. The average size of the fine droplets 5 is preferably 4 micrometers or less, and more preferably 2 micrometers or less. For good inhalation, a size of about 1 micrometer is also acceptable. Providing thin, fine droplets that can easily flow into the lungs is precisely the purpose of this device.

[0040] The aerosol chamber 13 may be equipped with an air inlet 6 that allows for the intake of fresh air from the outside while the liquid composition S is being inhaled. The air inlet 6 may be equipped with a valve that allows the air inlet to be opened and closed. Such a valve can be adjusted to match the ratio of fresh air intake to the internal aerosol of the microdroplets 5. The ratio of fresh air to microdroplets 5 can be, for example, about 50 / 50. Alternatively, the intake volume may consist of more fresh air than microdroplets, with a ratio of fresh air to microdroplets 5 higher than 60 / 40, and alternatively higher than 80 / 20. Alternatively, the intake volume may contain less fresh air than microdroplets, with a ratio of fresh air to microdroplets 5 lower than 40 / 60, and alternatively lower than 20 / 80.

[0041] The air intake port 6 may be equipped with a filter to prevent the inhalation of airborne impurities and fine particles. In this way, the aerosol of the fine droplets 5 is mixed with the outside air in a predetermined ratio when the user inhales the liquid composition S.

[0042] The air inlet 6 may be visible on the housing 10 of the device 1 at the same height (level) as the aerosol chamber 13. Alternatively, the air inlet 6 may be visible on the housing 10 at the level of the volatile elements, the level of the preheating chamber 12, or the level of the storage compartment 11. This means that outside air moves within the housing 10 of the device 1 from the air inlet 6 to the aerosol chamber 13. For example, air can move around the preheating chamber 12 via a double wall. The intake air can then be preheated in the same way as the liquid composition S by being close to the preheating chamber 12.

[0043] The aerosol chamber 13 also includes a mouth port 9 that allows the user to inhale the liquid composition S.

[0044] The aerosol chamber 13 may further comprise one or more aerosol heating units 130. Any device that provides heat, such as an electrical resistor, can be used as a heating unit. The aerosol heating unit 130 may be positioned near the air inlet 6 to preheat the external air to a suitable temperature, particularly to avoid condensation of the fine droplets 5. Such a positioning is particularly suitable when the air inlet 6 is located directly in the aerosol chamber 13. In particular, the aerosol heating unit may be an electrical resistor such as a metal or coil or metal-ceramic heating unit with low resistance, preferably between about 0.1 ohms and about 2 ohms, and the aerosol heating unit may more advantageously be a sub-ohm or metal-ceramic heating unit. Alternatively, the aerosol heating unit may be of infrared type. Such infrared heating units may comprise, for example, a polyimide or carbon infrared heating unit with a wavelength of about 3 to 14 μm. An infrared heating unit with a wavelength corresponding to the absorbance of water is preferably used.

[0045] To ensure that the mixture of aerosol droplets and fresh outside air is drawn in at an appropriate temperature, an aerosol heating unit 130 may be placed near the mouse port 9, either as an alternative or additional measure.

[0046] Optionally, the aerosol chamber 13 may be provided with means for collecting condensed aerosols that are not inhaled by the user. The size of the aerosol droplets is designed to increase or optimize the fraction that is inhaled and the fraction that accumulates on the surface of the device 1. However, a small portion of the aerosol may condense on the inner surface of the aerosol chamber 13. Means adapted for collecting such condensed material may be in the shape of one or more recessed walls positioned at the bottom to collect the condensed fluid. The bottom position means the lowest part of the device 1, whether stationary, in use, or both. The means for collecting the condensed fluid may further include one or more capillaries connected by recessed walls to return these condensed fluids to the upstream part of the device 1. The capillaries of the collection means can then connect the recessed walls of the aerosol chamber 13 to the volatile elements. The condensed liquid thus collected passes through the vibrating elements and volatilizes again. Alternatively or additionally, the capillary tubes of the recovery means merge into the preheating chamber 12. The condensed liquid thus recovered can be heated again to an appropriate temperature and volatilized again. Alternatively or additionally, the capillary tubes of the recovery means merge into the storage compartment 11. In this way, the recovered condensed fluid is returned to the entire circuit.

[0047] As shown in Figure 1, the preheating chamber 12 and the aerosol chamber 13 are arranged in communication with each other, and volatile elements such as the vibrating mesh 14 are positioned along the lateral direction across the space between the preheating chamber 12 and the aerosol chamber 13. Such an arrangement is well suited to a device in which the preheating chamber 12, the aerosol chamber 13, and the mouth port 9 are aligned in this order along the longitudinal axis of the device 1. Such an arrangement is suitable, for example, for single-shot inhalation of products such as pharmaceuticals.

[0048] In the particular configurations best illustrated by Figures 4a, 4b, 5a, and 5b, the storage compartment 11 in the apparatus 1 according to this disclosure takes the form of a lateral space between the aerosol chamber 13 and the housing 10 of the apparatus 1. In other words, the storage compartment 11 surrounds the side wall 121 of the aerosol chamber 13 for a portion of its length. For example, the storage compartment 11 may surround the side wall 121 of the aerosol chamber 13 for a height between 10% and 80% of its length, or between 20% and 60% of its length, for example, between 30%, 40%, or 50% of its length. It may surround the entire perimeter of the aerosol chamber 13, as well as best illustrated by Figures 4a and 4b, or it may surround only a portion of its perimeter, as well as best illustrated by Figures 5a and 5b.

[0049] A portion of the aerosol chamber 13 is also surrounded by a preheating chamber 12, either entirely or in part, on its outer perimeter. The storage compartment 11 and the preheating chamber 12 are fluidly connected by at least one solution inlet 110. Multiple solution inlets 110 may be arranged around the outer perimeter of the aerosol chamber 13, i.e., on a common surface between the storage compartment 11 and the preheating chamber 12. The solution inlets may have all the features described above. In particular, as shown in Figure 2, they may comprise at least one of multiple solution inlets 110a, 110b and multiple capillaries 12a, 12b. The preheating chamber 12 may extend between 10% and 80% of the length of the aerosol chamber 13, or between 20% and 60%, such as 30%, 40%, or 50% of its length.

[0050] As a result of this arrangement, the upper part of the side wall 121 of the aerosol chamber 13 is at least partially surrounded by the storage compartment 11, and the lower part of the side wall 121 of the aerosol chamber 13 is at least partially surrounded by the preheating chamber 12. The upper part here refers to the part closest to the mouse port 9 and corresponds to the orientation of the device 1 when used by the user. In other words, although the storage compartment 11 is closer to the mouse port 9 than the preheating chamber 12, the preheating chamber 12 is still upstream of the aerosol chamber 13 when considering the path of solution S from the storage compartment 11 to the mouse port 9.

[0051] One or more heating devices 120a, 120b are arranged around the side wall 121 of the aerosol chamber 13 within the preheating chamber 12. One or more volatile elements, such as vibrating meshes 14a, 14b, are arranged on the side wall 121 of the aerosol chamber 13 so as to push out the droplets 5 inside the aerosol chamber 13. The heating devices 120a, 120b may be arranged facing the volatile elements. In that case, one or more pairs of volatile elements and heating devices 120a, 120b surround the aerosol chamber 13. Alternatively, the heating device 120 may be arranged in the preheating chamber 12 independently of the volatile elements.

[0052] This configuration represents an advantage of the more compact device 1, at least along its longitudinal axis. In addition, the side walls 121 of the aerosol chamber 13 are spaced apart from the housing 10 and do not come into contact with the external environment. In particular, the storage compartment 11 and the preheating chamber 12 form a space between the housing 10 and the aerosol chamber 13. As a result, the temperature inside the aerosol chamber 13 can be better controlled by limiting the possible temperature exchange between the aerosol chamber and the external environment.

[0053] The volatile elements, such as the vibrating mesh 14, are integrated into the side wall 121 of the aerosol chamber 13, rather than being lateral to the side wall 121, as shown in Figure 1. The heating device 120 is schematically represented by a resistor in Figures 4a, 4b, 5a, and 5b, but can take any suitable form comprising the above-described features.

[0054] Figures 4a, 4b, 5a, and 5c show a single preheating chamber 12, but this does not preclude the provision of multiple similar preheating chambers 12 around the aerosol chamber 13. For example, several solution inlets 110a, 110b may lead the solution S into several preheating chambers 12 (each preheating chamber as described herein). Corresponding vibrating meshes 14 are positioned on the side walls 121 to expel droplets 5 through a common aerosol chamber 13.

[0055] The side walls 121 of the aerosol chamber 13 may be provided with one or more volatile elements, such as vibrating meshes 14. Preferably, multiple vibrating meshes 14 are arranged around the outer periphery of the aerosol chamber 13.

[0056] In certain configurations, the vibrating meshes 14 vibrate independently of each other. However, especially when they are closed to each other, the combination of vibration frequencies of the meshes 14 can affect the flow rate of the solution S in an uncontrolled manner. To avoid or limit the effects of uncontrolled interactions between the vibrating meshes 14, an internal partition wall 15 may be provided in the preheating chamber 12 between two opposing vibrating meshes 14, as better shown in Figure 4b. Such a partition wall 122 preferably partitions only a portion of the aerosol chamber 13. It may be plain, but may have through-holes so as not to completely close the space between the vibrating meshes 14. Depending on the number of vibrating meshes 14 integrated into the side walls 121 of the aerosol chamber 13, the partition wall 122 can take any suitable shape. For example, it could be a straight wall positioned in the center of the aerosol chamber 13 between two opposing vibrating meshes 14. Alternatively, it may consist of multiple arc-shaped walls, each facing a given vibrating mesh 14. Alternatively, a central cylinder may be positioned at the level of the vibrating meshes within the aerosol chamber to avoid uncontrolled interference. A person skilled in the art would optimize the shape and number of partition walls 122 for this purpose.

[0057] In specific embodiments, such a partition wall 122 may include a heating element that acts as an aerosol heating section 130. If such an aerosol heating section 130 is present, it can be positioned between the vibrating mesh 14 to limit or avoid interference with the flow rate of the solution S and the corresponding uncontrolled effects. Such a heating element 130 can be designed as a coil oriented vertically within the aerosol chamber 13 at the level of the vibrating mesh 14.

[0058] In one embodiment, the frequency of the vibrating mesh 14 can be controlled individually or collectively. For example, all vibrating meshes 14 can vibrate at the same predetermined frequency. Some adjacent vibrating meshes 14 can vibrate out of phase, with a predetermined phase difference, or in opposite phase. In this way, the uncontrollable effects of phase interference on the solution flow rate are avoided. If the flow rate is changed by the user, all vibrating meshes 14 maintain their phase difference by changing the vibration frequency.

[0059] In another embodiment better represented by Figure 5a, the preheating chamber 12 may extend along the aerosol chamber 13 over a longer distance than the storage compartment 11. For example, the preheating chamber 12 may occupy a portion of the sidewall 121 larger than the portion occupied by the storage compartment 11, by a coefficient of 30%, 50%, 100%, or even 200% or more. Multiple vibrating meshes 14 can then be arranged along the length of the aerosol chamber 13. This configuration can improve the flow of particles 5 toward the aerosol chamber 13. Such a configuration does not preclude the possibility of installing multiple vibrating meshes 14 at a predetermined height in the aerosol chamber 13, as described above.

[0060] Depending on the configuration and dimensions of the preheating chamber 12 and the aerosol chamber 13, and the location of the vibrating mesh 14, the phase difference between adjacent vibrating meshes 14 may be a target of specific control. For example, instead of changing the frequency, or alternatively in addition to changing the frequency, the user can change the phase difference between adjacent meshes to adjust the flow rate. For example, by selecting two adjacent vibrating meshes 14 with completely opposite phases, the maximum flow rate can be provided. Reducing the phase difference will reduce the flow rate. If there is no phase difference between opposing vibrating meshes 14, they will complement each other, and a large flow rate cannot be obtained.

[0061] For better control, the phase difference can be modified according to the selected frequency. In other words, the phase difference is adjusted according to the frequency or range of vibration frequencies of the vibration mesh 14.

[0062] Only frequency control or phase difference control of the partition wall 122 and the vibration mesh 14 may be considered. Alternatively, a combination of frequency and / or phase difference control of the partition wall 122 may be considered as needed.

[0063] In addition to or instead of frequency control, the vibration amplitude of the vibration mesh 14 can also be individually or collectively controlled as an alternative.

[0064] In another embodiment, better illustrated by Figure 5b, the apparatus 1 comprises one or more piezoelectric pumps 125 in addition to, or alternatively to, one or more vibrating meshes 14. Such piezoelectric pumps 125 are located in the preheating chamber 12. They are combined with the vibrating meshes 14 to obtain better volatilization efficiency. Furthermore, the heating device 120 may be combined with the piezoelectric pumps to form an assembly comprising the heating device 120 and the vibrating meshes 14.

[0065] The end of the aerosol chamber 13 may be provided with means for recovering the condensed liquid 15. Such means may be limited to the porous portion or capillary assembly at the end of the aerosol chamber 13. Alternatively or additionally, one or more vibrating meshes may be provided to collect residue and return it to the aerosol chamber 13. Such vibrating meshes may have a predetermined frequency and amplitude. Possess These are preferably constant and not modifiable. This does not preclude the possibility of making one or both of the frequency and amplitude modifiable for certain needs, such as during cleaning or maintenance processes.

[0066] The air inlet 6 may be present in other embodiments shown in Figures 4a, 4b, or 5a, but is better represented in Figure 5b, and is preferably located at the level of the aerosol chamber 13 containing the volatile elements, i.e., at the bottom of the aerosol chamber 13.

[0067] The overall design of this device allows one or more of its elements to be removed. For example, it can be modular, having a first removable component with a storage compartment, a second removable component related to the preheating chamber 12, a third removable component corresponding to the volatile element, and a fourth component related to the aerosol chamber 13. In this way, any of these modular components can be separated, cleaned, or replaced independently of the other components. In a specific embodiment, the volatile element, or at least the mesh 14 it comprises, can be easily detached by the user from the device 1 for cleaning or replacement with a new one. This facilitates the user's maintenance of the device 1 and allows for the maintenance of proper volatilization conditions for the solution S without potential deterioration of taste due to the accumulation of residues. However, it should be emphasized that, because there is no charring, the device 1 typically does not have any deterioration of the liquid or charred residues.

[0068] Alternatively or additionally, the apparatus 1 may enable one or more modes related to either disinfecting or cleaning at least some of the components of the apparatus 1 using a dedicated cleaning solution. Such cleaning solutions may be, for example, acidic solutions, basic solutions, preservative solutions, alcoholic solutions, or a selection of such solutions used in a specific sequence. In cleaning mode, the cleaning solution may be introduced into the storage compartment 11 to circulate throughout the entire circuit of the apparatus.

[0069] The apparatus according to this disclosure further comprises a command input unit 22 such as an input button, or a combination of input buttons, or a tactile display, or any relevant input command that the user can activate. The command input unit is connected to a command unit 20 adapted to adjust the heating device 120 of the preheating chamber 12. The command unit 20 can further enable modulation of the vibration frequency of the mesh 14 of volatile elements. The command unit 20 may further enable modulation of the aerosol heating unit 130 or a plurality of aerosol heating units. The command unit may further enable adjustment of the fresh air inlet by more or less closing the air inlet 6. The apparatus 1 may further comprise a display unit 21 that enables the user to input data and to receive information regarding the status of the apparatus 1. The apparatus 1 may further comprise a communication unit 30 that enables some data sharing with a remote system. Such a remote system may be a platform that provides the user of the apparatus with services or information such as usage notifications or specific settings regarding the liquid composition S. Such updates may relate to better processes, for example, the mutual control of the heating devices 120 and the vibration frequency of the volatile elements. Possible to be involved The remote system can, alternatively, designate another device of the user, such as a mobile phone or computer.

[0070] The input command unit 22 allows the user to select a debit or a predetermined amount of aerosol 5 or any other variable. For ease of use, the command unit 20 may automatically select an appropriate combination of the temperature of the heating device 120, the aerosol heating unit 130, and the vibration frequency of the volatile element to provide the user with the requested result. In addition, the command unit 20 may automatically select an appropriate combination of the temperature of the heating device 120 and the vibration frequency of the volatile element to ensure that the minimum energy is consumed. For example, if the heating of the heating device 120 is lower than necessary to provide the appropriate viscosity of the liquid composition S, and the global energy consumption appears low for a given result, this is compensated for by increasing the vibration frequency of the volatile element. Furthermore, the activation of the heating device 120 and the volatile element may also be adapted according to the autonomy of the device 1. It is emphasized here that the device 1 may include a battery and a plug-in means for recharging the battery.

[0071] The input command unit 22 may further enable the selection of a cleanup mode, a maintenance mode, or any other specific mode for the device 1.

[0072] The apparatus according to this disclosure thus enables the provision of an aerosol having thin microdroplets based on a liquid composition S having relatively high viscosity. Furthermore, the combination of the heating element 120 and the vibrating mesh 14 enables the generation of such microdroplets with minimal energy consumption. High-viscosity liquid compositions require stronger vibrations to generate microdroplets and therefore consume more energy. Even under such conditions, the size of the generated microdroplets may not be as homogeneous or as thin as those in the aerosol provided with a preheating chamber 12 upstream of the volatile elements.

[0073] The present invention further relates to a kit comprising an apparatus 1 and at least one liquid composition S. The liquid composition S may be separately filled in a tank adapted to fill or replenish a storage compartment 11. The liquid composition S may be separately filled in a cartridge adapted to be connected to the apparatus 1. Such a cartridge may be equipped with a readable device such as RFID, or any similar device that enables automatic identification of properties of the liquid composition, including at least one of its viscosity at a given temperature and its expiration date. Other properties may be stored in the readable device. The readable device may be automatically read by the apparatus 1 so that appropriate settings are suggested to or automatically applied to the user via a display unit 21. The kit may be equipped with additional liquid compositions S to provide the user with a wide variety of choices. If the liquid composition contains a medical treatment or any pharmaceutical compound, the kit may be equipped with a corresponding usage notice.

[0074] The liquid composition S of the present invention is preferably an aqueous composition. Therefore, the liquid composition S contains more than about 60% by weight of water, more preferably 70% by weight or even more preferably more than 80% by weight of water, the amount of which is determined with respect to the total weight of the liquid composition S. The water may be water of pharmaceutical quality such as mineral water, distilled water, pure water, or water for injection. For this purpose, the complete liquid composition S can be subjected to sterilization.

[0075] The liquid composition S of the present invention further contains one or more substances that have a biological effect through inhalation. Such substances include, for example, ventolin, or any other drugs commonly used to treat respiratory symptoms or diseases such as asthma, as well as acceptable salts thereof. The substances in the liquid composition S may also be or contain nicotine, also known as pyridine-3-(1-methyl-2-pyrrolidinyl). The substance may be a nicotine derivative or a salt thereof. Examples of nicotine derivatives include 4-nitronicotine-N-oxide, 4-aminonicotine, nornicotine, anabasine, myosmin, nicotine, and anatabine. Nicotine or nicotine derivatives may be combined with salts selected from the group consisting of sulfates, tartrates, hexafluorosilicates, hydrochlorides, digate formate, triacetates, trippropionates, triptylates, isovalerates, dinitrophenolates, dipicrates, dihydrochlorides, hydroiodides, piclonates, phthalates, dipiclorates, quinocylochlorides, benzoic acid, levunilic acid, pyruvic acid, or combinations thereof.

[0076] These substances may, alternatively, be natural oils or natural plant extracts, or contain natural oils or natural plant extracts. For example, such substances may be cannabinoids such as tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), cannabigerol (CBG), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), and cannabichromene (CBC).

[0077] The substance in liquid composition S may consist of an amount between 1% and 10% by weight of the composition.

[0078] Liquid composition S may further contain polyols, particularly diols. Such polyols can be selected from the group consisting of propylene glycol (propane-1,2-diol), begetol (propane-1,3-diol), glycerin (propane-1,2,3-triol), propane-1-1-diol, propane-2-2-diol, butane-1,4-diol, butane-1,3-diol, butane-2,3-diol, and pentane-1,5-diol, or mixtures thereof. Liquid composition S contains polyols in an amount between 3 and 40%, preferably between 5% and 35% by weight.

[0079] Flavor enhancers are sometimes needed to transfer flavor from aqueous solutions. Polyols can be used as such flavor enhancers. Preferred polyols used as flavor enhancers are propylene glycol (PG) and vegetable glycerin (VG). For example, combinations of propylene glycol (PG) and vegetable glycerin (VG) can be used in PG / VG ratios of approximately 80 / 20, 70 / 30, 60 / 40, and 50 / 50. Several solutions with more VG than PG, such as PG / VG ratios of approximately 40 / 60, 30 / 70, or 40 / 60, can also be used. The ratio can be determined by volume or by weight.

[0080] The amount of polyol in solution S may affect its flow rate in apparatus 1. In a preferred embodiment, the polyol / water ratio is between 10 / 90 and 20 / 80 by volume. Such a solution is preferably stored in a sterile sealed tank. Such a sterile sealed tank can be directly engaged in apparatus 1 by supplying it to the preheating chamber 12 to generate particles 5.

[0081] However, solutions containing a polyol / water ratio of 20 / 80 or higher, for example 30 / 70 or 40 / 60 by volume, can still be used in the apparatus 1. In particular, despite the possibility of increased viscosity of such solutions due to the increase in the proportion of polyol, the above configuration ensures that an appropriate flow rate can be obtained. Solutions with a polyol / water ratio of 20 / 80 or higher have the advantage of being less susceptible to bacterial growth. Such solutions do not need to be sterilized and sealed in a sterile sealed tank. Such solutions can then be stored in a receiving section that can be used to replenish the storage compartment 11 of the apparatus as needed, without the need for systematic involvement of sealed capsules. That being said, the apparatus claimed here is particularly well suited to receiving solutions with a polyol / water ratio of less than 20 / 80 by volume or 20 / 80 or higher by volume.

[0082] In the case of e-cigarettes, aqueous solutions may not properly transmit the taste and aroma of nicotine. To improve the transmission of taste to the user, a combination of particle size reducers and flavor enhancers, which are also used as surfactants, can be used. Therefore, a combination of particle size reducers and flavor enhancers may be necessary for proper taste transmission.

[0083] The liquid composition S of the present invention may contain one or more fragrances. Furthermore, it may contain a bactericide (triacetin), a disinfectant, or a preservative compound such as an antioxidant.

[0084] The present invention further comprises a method for vaporizing a liquid composition S having a viscosity higher than 2, 3, or 5 Cp at 20°C into an aerosol suitable for inhalation. This method comprises a heating step a) in which the solution S is continuously and instantaneously preheated at a temperature lower than its boiling point, so that no vapor is generated and no deterioration of the product occurs. The preheated solution S is then directly subjected to a diffusion step b) in which the preheated liquid solution S is volatilized to an average diameter of less than 4 μm, for example, about 1 μm.

[0085] Steps a) and b) are preferably performed simultaneously. These can be manually initiated by the user via the command button 22.

[0086] The method of the present invention further comprises a modulation step c) which modulates one or more of the following: the temperature of the preheating chamber 12, the vibration frequency of the volatilization element, and the temperature of the aerosol heating section. Modulation step c) includes user selection of a debit (amount used in one use) and automatic modulation of the heating device 120 and automatic modulation of the vibration frequency of the volatilization element by the command unit 20. If there are multiple vibration actuators 14, modulation step c) may sequentially operate the vibration actuators to increase or decrease the flow rate of the liquid composition toward the aerosol. One or more vibration actuators may be operated independently. This application offers, for example, the following perspectives. [Perspective 1] A housing (10) having a storage compartment (11) suitable for storing a liquid composition (S), A volatile element adapted to volatilize the liquid composition (S) into minute droplets (5), Aerosol chamber (13) and In a device (1) equipped with, The apparatus further comprises at least one preheating chamber (12) downstream of the storage compartment (11) that is in fluid communication with the storage compartment (11) by at least one solution inlet (110), The at least one preheating chamber (12) is equipped with one or more heating devices (120) and is located upstream of the volatile elements, The aerosol chamber (13) is located downstream of the volatile element, and the aerosol chamber is equipped with or connected to a mouse port (9). It is characterized by, The preheating chamber (12) and the aerosol chamber (13) are arranged such that the volatile elements are in communication with each other along the lateral position between them, or The apparatus (1) is characterized in that the preheating chamber (12) is in the form of one or more lateral spaces surrounding the aerosol chamber (13) having the volatile elements arranged in the corresponding side wall (121). [Perspective 2] The apparatus according to aspect 1, wherein the heating device is adapted to heat the liquid composition (S) at a temperature below its boiling point so as not to cause an increase in pressure, or substantially so as not to cause an increase in pressure. [Perspective 3] The apparatus according to viewpoint 1 or 2, wherein the volatile element is combined with at least one piezoelectric or magnetoelectric actuator comprising at least one vibrating mesh (14) having one or more flat porous membranes with a pore diameter of about 1 μm or less, or with at least a piezoelectric pump or a combination of both. [Perspective 4] The apparatus according to aspect 3, wherein the volatile element means one or more vibrating meshes (14) adapted to vibrate at frequencies consisting of approximately 50 kHz and approximately 150 kHz or approximately 500 kHz and approximately 1500 kHz, or comprising the vibrating meshes (14). [Perspective 5] The apparatus according to any one of views 1 to 4, wherein the volatile element means one or more vibrating meshes (14) comprising non-planar porous material adapted to increase the contact surface between the liquid composition (S) and at least one of the multiple layers of porous material, or comprising the vibrating meshes (14). [Perspective 6] The apparatus according to any one of views 1 to 5, wherein the preheating chamber (12) comprises one or more capillaries or porous materials that drive the liquid composition (S) in contact with the volatile element. [perspective 7] The apparatus according to any one of views 1 to 6, wherein the aerosol chamber (13) further comprises an air inlet (6) adapted to combine the inhaled microdroplets (5) with outside air via the mouth port, or is connected to the air inlet (2). [Perspective 8] The apparatus according to any one of views 1 to 7, wherein the aerosol chamber (13) further comprises at least one aerosol heating unit (130). [Perspective 9] The apparatus according to any one of views 1 to 8, wherein the at least one preheating chamber (12) takes the form of one or more lateral spaces surrounding the aerosol chamber (13), and the volatile elements comprise one or more vibrating meshes (14) arranged on the corresponding side walls (121). [Perspective 10] The apparatus according to view 9, further comprising two or more vibration meshes (14) facing each other, and at least one inner wall (122) located between the vibration meshes. [Perspective 11] The apparatus according to viewpoint 10, wherein the inner wall (122) represents a heating element that functions as an aerosol heating section (130). [Perspective 12] The aerosol chamber (13) is surrounded by a plurality of preheating chambers (12), Between the aforementioned preheating chambers (12), or Between the preheating chamber (12) and the housing (10), or Both between the preheating chambers (12) and between the preheating chambers (12) and the housing (10) The apparatus described in perspective 10 or 11, which corresponds to the device described in perspective 10 or 11. [Perspective 13] The apparatus according to any one of views 1 to 12, further comprising a means for recovering residue, wherein such means comprises one or more porous materials, a capillary assembly, and at least one vibrating mesh. [Perspective 14] · The temperature of the preheating chamber (12), or ·When one or more vibration meshes (14) are represented, one or both of the frequency and amplitude of the vibration of the volatile element, • When one or more vibration meshes (14) are represented, the combination of the temperature of the preheating chamber and one or both of the frequency and amplitude of the vibration of the volatile element. The apparatus according to any one of views 1 to 13, further comprising a command input section (22) adapted for modulation. [Perspective 15] The apparatus according to any one of viewpoints 1 to 14, wherein the volatile element comprises two or more vibrating meshes (14), and at least some of the adjacent vibrating meshes (14) vibrate with a controlled phase difference. [Perspective 16] The apparatus according to viewpoint 15, wherein the phase difference can be adjusted with respect to the frequency of vibration or the range of vibration frequencies. [Perspective 17] A method for volatilizing a liquid composition (S) into minute droplets (5) with a diameter of less than 4 μm using any one apparatus from viewpoints 1 to 16, wherein the liquid composition has a viscosity greater than 2 cP at 20°C, and the method is A heating step a) involves preheating the liquid composition (S) to a temperature lower than its boiling point to prevent vapor generation, A diffusion step b) involves volatilizing a preheated liquid composition into minute droplets (5) having an average diameter of less than approximately 4 μm. A method for volatilizing a liquid composition (S) into minute droplets (5) with a diameter of less than 4 μm, comprising the above. [Perspective 18] The temperature of the preheating chamber (12) and The vibration frequency, amplitude, and phase difference of the vibration mesh, one or more of these, Number of vibration actuators and The method of viewpoint 17, further comprising modulation step c), wherein at least one of the is modulated when applicable. [Perspective 19] The method according to aspect 17 or 18, wherein the liquid composition comprises more than 60% water, 1% to 10% of a substance having a viscosity greater than 2 cP at 20°C and having biological effects under inhalation conditions, and 5% to 40% of a polyol, and the liquid composition is substantially free of additional organic solvents. [perspective 20] The method according to aspect 19, wherein the polyol / water ratio in the liquid composition is between 10 / 90 and 20 / 80, and the composition is stored in a sterile, sealed tank adapted to engage within the apparatus (1). [Perspective 21] The method according to aspect 19, wherein the polyol / water ratio in the liquid composition exceeds 20 / 80, and the liquid composition is stored in a non-sterile recipient that can be used to replenish the apparatus (1). [Perspective 22] The method according to any one of views 19 to 21, wherein the liquid composition further comprises one or more flavors. [Perspective 23] The method according to any one of views 17 to 20, wherein the substance is selected from nicotine, nicotine derivatives, tetrahydrocannabinol (THC), or the cannabinoid family or pharmaceutically acceptable salts thereof. [Explanation of Symbols]

[0087] 1 device 10 cabinets 11 Storage compartments 110 Solution Inlet 12 Preheating chamber 120 Heating section 121 Side wall 122 Partition wall 125 Piezoelectric pump 13 Aerosol Room 130 Aerosol heating section 14 Vibration Mesh 15. Residue recovery methods 20 Command Units 21 Display section 22 Command Buttons 30 Communication Units 5 droplets 6. Air Inlet 8. Heated aerosol 9 Mouse Ports

Claims

1. A housing (10) having a storage compartment (11) suitable for storing a liquid composition (S), A volatile element comprising at least one vibrating mesh (14), wherein the volatile element is adapted to volatilize the liquid composition (S) into minute droplets (5), Aerosol chamber (13) and In a device (1) equipped with, The apparatus further comprises at least one preheating chamber (12) downstream of the storage compartment (11) that is in fluid communication with the storage compartment (11) by at least one solution inlet (110), The at least one preheating chamber (12) is equipped with one or more heating devices (120) and is located upstream of the volatile element, The aerosol chamber (13) is located downstream of the volatile element, and the aerosol chamber is equipped with or connected to a mouse port (9). The preheating chamber (12) comprises a plurality of capillaries, the tips of which coincide with the corresponding vibrating mesh, and the liquid composition (S) flowing continuously through the capillaries in direct contact with the vibrating mesh, thereby ensuring that the minute droplets have an average diameter of 4 micrometers or less. The preheating chamber (12) and the aerosol chamber (13) are arranged such that the volatile elements are in communication with each other along the lateral position between them, or In the apparatus (1), the preheating chamber (12) has the form of one or more lateral spaces surrounding the aerosol chamber (13) having the volatile elements arranged on the corresponding side wall (121), The apparatus (1) is characterized in that the inner diameter of the capillary tube decreases by a value of 10% to 50% from one end of the capillary tube to the other end.

2. The apparatus according to claim 1, wherein the heating device is adapted to heat the liquid composition (S) at a temperature below its boiling point so as not to cause an increase in pressure, or substantially so as not to cause an increase in pressure.

3. The at least one vibration mesh (14) It comprises one or more flat porous membranes with a pore size of approximately 1 μm or less, At least one piezoelectric or piezoelectric magnetic actuator is combined, It comprises at least one piezoelectric pump, or The apparatus according to claim 1 or 2, comprising a combination of the piezoelectric or piezoelectric magnetic actuator and the piezoelectric pump.

4. The apparatus according to claim 3, wherein the at least one vibrating mesh (14) is adapted to vibrate at frequencies consisting of about 50 kHz and about 150 kHz or about 500 kHz and about 1500 kHz.

5. The apparatus according to any one of claims 1 to 4, wherein the at least one vibrating mesh (14) comprises a non-planar porous material adapted to increase the contact surface between the liquid composition (S) and at least one of the multiple layers of porous material.

6. The apparatus according to any one of claims 1 to 5, wherein the aerosol chamber (13) further comprises an air inlet (6) adapted to combine the inhaled microdroplets (5) with outside air via the mouth port, or is connected to the air inlet (2).

7. The apparatus according to any one of claims 1 to 6, wherein the aerosol chamber (13) further comprises at least one aerosol heating unit (130).

8. The at least one preheating chamber (12) takes the form of one or more lateral spaces surrounding the aerosol chamber (13), The apparatus according to any one of claims 1 to 7, wherein at least one vibrating mesh (14) is arranged on a corresponding side wall (121).

9. The apparatus according to claim 8, further comprising two or more of the vibration meshes (14) facing each other, and at least one inner wall (122) located between the vibration meshes.

10. The apparatus according to claim 9, wherein the inner wall (122) represents a heating element that functions as an aerosol heating section (130).

11. The apparatus according to claim 9 or 10, wherein at least a portion of the aerosol chamber (13) is surrounded by at least one preheating chamber (12).

12. The apparatus according to any one of claims 1 to 11, further comprising a means for recovering residue, wherein such means comprises one or more porous materials, a capillary assembly, and at least one vibrating mesh.

13. - The temperature of the preheating chamber (12), or - One or both of the frequencies and amplitudes of one or more vibrations of the vibration mesh (14), or - A combination of the temperature of the preheating chamber and one or both of the frequency and amplitude of one or more vibrations of the vibration mesh (14) The apparatus according to any one of claims 1 to 12, further comprising a command input unit (22) adapted for modulation.

14. The volatile element comprises a plurality of the vibration mesh (14), Among the multiple vibration meshes, some adjacent vibration meshes vibrate with a controlled phase difference. The apparatus according to any one of claims 1 to 13, wherein the phase difference is adjusted with respect to the frequency of vibration or the range of vibration frequencies.

15. The apparatus according to any one of claims 1 to 14, wherein one or more heating devices are separated from the walls of the capillaries and surround the plurality of capillaries, allowing for smooth temperature changes.

16. A method for volatilizing a liquid composition (S) into minute droplets (5) with a diameter of less than 4 μm using the apparatus described in any one of claims 1 to 15, wherein the liquid composition has a viscosity higher than 2 cP at 20°C, and the method is A heating step a) involves preheating the liquid composition (S) to a temperature lower than its boiling point to prevent vapor generation, A diffusion step b) involves volatilizing a preheated liquid composition into minute droplets (5) having an average diameter of less than approximately 4 μm. A method for volatilizing a liquid composition (S) into minute droplets (5) with a diameter of less than 4 μm, comprising the above.

17. The temperature of the preheating chamber (12) and The vibration frequency, amplitude, and phase difference of the vibration mesh, one or more of these, Number of vibration actuators and The method according to claim 16, further comprising modulation step c), which modulates at least one of the following, if applicable.

18. The method according to claim 16 or 17, wherein the liquid composition comprises more than 60% water, 1% to 10% of a substance having a viscosity greater than 2 cP at 20°C and having biological effects under inhalation conditions, and 5% to 40% of a polyol, and the liquid composition is substantially free of additional organic solvents.

19. The method according to claim 18, wherein the polyol / water ratio in the liquid composition is between 10 / 90 and 20 / 80, and the composition is stored in a sterile, sealed tank adapted to engage within the apparatus (1).

20. The method according to claim 18, wherein the polyol / water ratio in the liquid composition exceeds 20 / 80, and the liquid composition is stored in a non-sterile receiving section that can be used to replenish the apparatus (1).

21. The method according to any one of claims 18 to 20, wherein the liquid composition further comprises one or more flavors.

22. The method according to any one of claims 18 to 21, wherein the substance is selected from nicotine, nicotine derivatives, tetrahydrocannabinol (THC), or the cannabinoid family or pharmaceutically acceptable salts thereof.

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