Emulsion composition

Abstract

To provide a cubic liquid crystal emulsified composition that is excellent in both separation stability and usability.SOLUTION: An emulsified composition comprises: (A) an ether-based nonionic surfactant, (B) a higher fatty acid, and (C) lidocaine. The composition is excellent in both separation stability and feel during use.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an emulsion composition. More specifically, the present invention relates to an emulsion composition excellent in separation stability and usability.

Background Art

[0002] Emulsion compositions are dosage forms that are advantageous in terms of drug efficacy and usability and are widely used in topical compositions. There are forms in which liquid crystals such as lamellar liquid crystals, inverse hexagonal liquid crystals, and cubic liquid crystals are applied to emulsion compositions, and all of them constitute characteristic emulsion systems.

[0003] Cubic liquid crystals are known as highly viscous liquid crystals and have begun to attract attention from the viewpoints of the permeability and absorbability of active ingredients (Non-Patent Documents 1, 2).

Prior Art Documents

Non-Patent Documents

[0004]

Non-Patent Document 1

Non-Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] The inventors focused on a cubic liquid crystal-based emulsified composition that offers excellent usability in that it provides a moderate film-like feel (skin protection) while suppressing stickiness. However, techniques for improving the separation stability of cubic liquid crystal-based emulsified compositions have not been sufficiently investigated, and the above-mentioned usability has not yet been achieved in conjunction with separation stability.

[0006] Therefore, the present invention aims to provide a formulation technology that excels in both separation stability and usability (i.e., moderate film-forming properties and anti-stickiness properties). [Means for solving the problem]

[0007] As a result of diligent research, the inventors have discovered that a cubic liquid crystal emulsifying composition with excellent separation stability and usability can be obtained by combining an ether-based nonionic surfactant, a higher fatty acid, and lidocaine. The present invention was completed by further research based on this finding.

[0008] In other words, the present invention provides inventions in the following embodiments. Item 1. An emulsified composition containing (A) an ether-based nonionic surfactant, (B) a higher fatty acid, and (C) lidocaine. Item 2. The emulsifying composition according to Item 1, wherein component (A) is a polyoxyalkylene alkyl ether, a polyoxyalkylene alkenyl ether, and / or a polyoxyalkylene steryl ether. Item 3. The emulsifying composition according to item 1 or 2, wherein the component (A) is a polyoxyalkylene alkyl ether and a polyoxyalkylene alkenyl ether. Item 4. The emulsified composition according to any one of items 1 to 3, wherein the total HLB value of component (A) is 11 to 18. Item 5. An emulsified composition according to any one of items 1 to 4, wherein the content of component (A) is 3 to 25% by weight. Item 6. The emulsifying composition according to any one of items 1 to 5, wherein the number of carbon atoms in component (B) is 14 or more. Item 7. The emulsified composition according to any one of items 1 to 6, wherein the content of component (B) is 0.1 to 1 part by weight per 1 part by weight of component (A). Item 8. The emulsified composition according to any one of items 1 to 7, wherein the content of component (C) is 0.05 to 0.5 parts by weight per 1 part by weight of component (A). Item 9. An emulsified composition according to any one of items 1 to 8, to be applied to the external genitalia. [Effects of the Invention]

[0009] According to the present invention, it is possible to provide a cubic liquid crystal emulsifying composition that is excellent in both separation stability and usability. [Modes for carrying out the invention]

[0010] The emulsifying composition of the present invention is characterized by containing (A) an ether-based nonionic surfactant (hereinafter also referred to as "component (A)"), (B) a higher fatty acid (hereinafter also referred to as "component (B)"), and (C) lidocaine (hereinafter also referred to as "component (C)"). The emulsifying composition of the present invention will be described in detail below.

[0011] (A) Ether-based nonionic surfactant The emulsifying composition of the present invention contains an ether-based nonionic surfactant as component (A). In the present invention, an ether-based nonionic surfactant refers to a nonionic surfactant having a structure in which a polyoxyalkylene group, which is the hydrophilic part, and a hydrocarbon group, which is the hydrophobic part, are linked by an ether bond.

[0012] Examples of alkylene oxides in the polyoxyalkylene group include alkylene oxides having 2 to 5 carbon atoms, preferably 2 to 3 carbon atoms, such as ethylene oxide, propylene oxide, and butylene oxide. These alkylene oxides may be included individually or in combination in the ether-based nonionic surfactant molecule. The number of moles of these alkylene oxides added can be, for example, 5 to 40, more preferably 7 to 36.

[0013] Specific examples of ether-based nonionic surfactants include polyoxyalkylene alkyl ethers (nonionic surfactants having a structure in which a polyoxyalkylene group and an alkyl group are linked by an ether bond), polyoxyalkylene alkenyl ethers (nonionic surfactants having a structure in which a polyoxyalkylene group and an alkenyl group are linked by an ether bond), and polyoxyalkylene steryl ethers (nonionic surfactants having a structure in which a polyoxyalkylene group and a steryl group are linked by an ether bond).

[0014] Examples of alkyl groups in polyoxyalkylene alkyl ethers include linear or branched alkyl groups having 10 to 24 carbon atoms. Specific examples of such alkyl groups include decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl (cetyl), heptadecyl, octadecyl (stearyl), nonadecyl, eicosyl, docosyl, tetracosyl, and decyltetradecyl groups. These polyoxyalkylene alkyl ethers may be used individually or in combination of multiple types. Among these polyoxyalkylene alkyl ethers, from the viewpoint of further improving separation stability, obtaining a better moderate film-forming effect, and / or further improving the stickiness suppression effect, preferred are linear alkyl groups having 12 to 22 carbon atoms (more preferably 14 to 20 carbon atoms, even more preferably 16 to 18 carbon atoms) and branched alkyl groups having 14 to 24 carbon atoms (more preferably 18 to 24 carbon atoms, even more preferably 22 to 24 carbon atoms). Preferred specific examples include hexadecyl (cetyl) group, heptadecyl group, octadecyl (stearyl) group, and decyltetradecyl group, with octadecyl (stearyl) group being a more preferred example.

[0015] Examples of alkenyl groups in polyoxyalkylene alkenyl ethers include linear or branched alkenyl groups having 10 to 24 carbon atoms, preferably 12 to 22 carbon atoms, and more preferably 14 to 20 carbon atoms. Specific examples of such alkenyl groups include decenyl, undecenyl, dodecenyl, tridecenyl, tetradecenyl, pentadecenyl, hexadecenyl, heptadecenyl, octadecenyl (oleyl), nonadecenyl, icocenyl, henicocenyl, dococenyl, tricocenyl, and tetracocenyl groups. These alkenyl groups may have double bonds at arbitrary positions. These polyoxyalkylene alkenyl ethers may be used individually or in combination of multiple types. Among these polyoxyalkylene alkenyl ethers, linear alkenyl groups having 12 to 22 carbon atoms, more preferably 16 to 20 carbon atoms, are preferred from the viewpoint of further improving separation stability, obtaining a moderate film-forming effect, and / or further improving the stickiness suppression effect. Preferred specific examples include hexadecenyl group, heptadecenyl group, octadecenyl(oleyl) group, nonadecenyl group, and icocenyl group, with octadecenyl(oleyl) group being a more preferred example.

[0016] Examples of steryl groups in polyoxyalkylene steryl ethers include cholesteryl groups (cholesterol residues), cholestaryl groups (cholestanol residues), stigmasteryl groups (stigmasterol residues), β-sitosteryl groups (β-sitosterol residues), lanosteryl groups (lanosterol residues), ergosteryl groups (ergosterol residues), phytosteryl groups (phytosterol residues), and their hydrogenation groups. These polyoxyalkylene steryl ethers may be used individually or in combination of multiple types. Among these polyoxyalkylene steryl ethers, phytosteryl groups (phytosterol residues) are preferred from the viewpoint of further improving separation stability, obtaining a more appropriate film-forming effect, and / or further improving the anti-stickiness effect.

[0017] In the present invention, as component (A), one of the above-mentioned polyoxyalkylene alkyl ethers, polyoxyalkylene alkenyl ethers, and polyoxyalkylene steryl ethers may be used, or a combination of multiple types may be used. Among the above-mentioned polyoxyalkylene alkyl ethers, polyoxyalkylene alkenyl ethers, and polyoxyalkylene steryl ethers, a combination of polyoxyalkylene alkyl ether and polyoxyalkylene alkenyl ether is preferred from the viewpoint of obtaining a moderate film-like effect more effectively and / or further improving the stickiness suppression effect.

[0018] In this invention, the total HLB value of component (A) is not particularly limited, but examples include 11 to 18. Here, the HLB value is a value that generally indicates the affinity of a surfactant for water and oil, and in this invention, the HLB value obtained by the Griffin method is adopted. The total HLB value is the value obtained by multiplying the individual HLB value of each compound used as component (A) by the weight ratio of that compound when the total weight of component (A) is set to 1, and then summing them up. For example, if component (A) contains only compound a with an HLB value of 15, the total HLB value is 15 (=15×1). Also, if component (A) contains compound a1 with an HLB value of 10 and compound a2 with an HLB value of 18 in a1:a2=4:6 (weight ratio), the total HLB value is 14.8 (=10×0.4+18×0.6). From the viewpoint of further improving separation stability, obtaining a better moderate film-forming effect, and / or further improving the stickiness suppression effect, the total HLB value of component (A) is preferably 12 to 16, more preferably 13 to 15, and even more preferably 13.8 to 14.5.

[0019] Particularly preferred examples of the component (A) include polyoxyethylene (20) polyoxypropylene (6) decyltetradecyl ether, polyoxyethylene (30) polyoxypropylene (6) decyltetradecyl ether, polyoxyethylene (20) polyoxypropylene (4) cetyl ether, polyoxyethylene (20) stearyl ether, polyoxyethylene (20) oleyl ether, polyoxyethylene (30) phytosterol. More preferably, polyoxyethylene (30) polyoxypropylene (6) decyltetradecyl ether, polyoxyethylene (20) polyoxypropylene (4) cetyl ether, polyoxyethylene (20) stearyl ether, polyoxyethylene (20) oleyl ether. Even more preferably, polyoxyethylene (20) stearyl ether, polyoxyethylene (20) oleyl ether may be mentioned.

[0020] In the emulsified composition of the present invention, the content of the component (A) is not particularly limited, and for example, 3 to 25% by weight may be mentioned. From the viewpoint of further improving the separation stability, obtaining a more suitable film feeling effect, and / or further improving the stickiness suppressing effect, the content of (A) is preferably 9 to 25% by weight, more preferably 10 to 22% by weight, and even more preferably 12 to 15% by weight.

[0021] (B) Higher fatty acids The emulsified composition of the present invention contains a higher fatty acid as the component (B). In the present invention, the higher fatty acid is a fatty acid having 12 or more carbon atoms.

[0022] Furthermore, the higher fatty acids may be either straight-chain fatty acids or branched fatty acids, and may be either saturated fatty acids or unsaturated fatty acids. Specific examples of component (B) include lauric acid, myristic acid, pentadecyl acid, palmitic acid, palmitoleic acid, margaric acid, stearic acid, oleic acid, vaccenic acid, linoleic acid, linolenic acid, eleostearic acid, arachidic acid, meadic acid, arachidonic acid, behenic acid, isopalmitic acid, isostearic acid, isoarachinic acid, etc. Preferred specific examples include isopalmitic acid, isostearic acid, and isoarachinic acid.

[0023] These higher fatty acids may be used individually or in combination of multiple types.

[0024] Among the above-mentioned higher fatty acids, from the viewpoint of further improving separation stability, obtaining a moderate film-forming effect more effectively, and / or further improving the stickiness suppression effect, higher fatty acids with 14 or more carbon atoms, more preferably 16 or more, and even more preferably 18 or more are selected. The upper limit of the carbon number of component (B) is, for example, 22 or less, preferably 20 or less, and more preferably 19 or less.

[0025] Furthermore, among the above-mentioned higher fatty acids, branched fatty acids and / or saturated fatty acids are preferred from the viewpoint of further improving separation stability, obtaining a more appropriate film-forming effect, and / or further improving the stickiness suppression effect, and more preferably branched saturated fatty acids.

[0026] Among the above-mentioned higher fatty acids, preferred specific examples of component (B) used in the present invention include isostearic acid and isoarachinic acid, and a particularly preferred specific example is isostearic acid.

[0027] In the emulsified composition of the present invention, the content of component (B) is not particularly limited, but for example, it is 2 to 10% by weight. From the viewpoint of further improving separation stability, obtaining a moderate film-like effect more effectively, and / or further improving the stickiness suppression effect, the content of (B) is preferably 3 to 8% by weight, more preferably 4 to 6% by weight.

[0028] In the emulsified composition of the present invention, the content ratio of component (B) to 1 part by weight of component (A) is determined by the above content of each component. However, from the viewpoint of further improving separation stability, obtaining a more appropriate film-like effect, and / or further improving the stickiness suppression effect, the content ratio of component (B) to 1 part by weight of component (A) is preferably 0.05 to 1 part by weight, more preferably 0.15 to 0.7 parts by weight, and even more preferably 0.3 to 0.5 parts by weight.

[0029] (C) Lidocaine The emulsified composition of the present invention contains lidocaine as component (C). Lidocaine, also known as xylocaine, is a known drug that has a local anesthetic effect. In the present invention, lidocaine imparts a moderate film-forming effect and an anti-stickiness effect to the emulsified composition containing components (A) and (B).

[0030] In the emulsified composition of the present invention, the content of component (C) is not particularly limited, but for example, it is 0.2 to 2% by weight. From the viewpoint of obtaining a moderate film-like effect more effectively and / or further improving the stickiness suppression effect, the content of (C) is preferably 1 to 2% by weight, more preferably 1.5 to 2% by weight.

[0031] In the emulsified composition of the present invention, the content ratio of component (C) to 1 part by weight of component (A) is determined by the above content of each component. However, from the viewpoint of obtaining a moderate film-like effect more effectively and / or further improving the stickiness suppression effect, the content ratio of component (C) to 1 part by weight of component (A) is preferably 0.02 to 0.5 parts by weight, more preferably 0.1 to 0.3 parts by weight, and even more preferably 0.1 to 0.2 parts by weight.

[0032] In the emulsified composition of the present invention, the content ratio of component (C) to 1 part by weight of component (B) is determined by the above content of each component. However, from the viewpoint of obtaining a moderate film-like effect more effectively and / or further improving the stickiness suppression effect, the content ratio of component (C) to 1 part by weight of component (B) is preferably 0.05 to 1 part by weight, more preferably 0.15 to 0.7 parts by weight, and even more preferably 0.3 to 0.5 parts by weight.

[0033] water The emulsifying composition of the present invention contains water as a base. The water content in the emulsifying composition of the present invention is not particularly limited, but for example, it is 45% by weight or more, preferably 46 to 85% by weight, more preferably 47 to 60% by weight, and even more preferably 48 to 55% by weight.

[0034] Oily base The emulsified composition of the present invention contains an oily base. Any oily base used in an emulsified composition can be used without particular limitation, but from the viewpoint of further improving separation stability, obtaining a better moderate film-like effect, and / or further improving the anti-stickiness effect, liquid oil is preferred. Examples of liquid oils include liquid hydrocarbon oils such as liquid paraffin, squalene, and squalane; silicone oils such as dimethylpolysiloxane and methylphenylpolysiloxane; medium-chain fatty acid triglycerides such as triglycerides of fatty acids with 6 to 12 carbon atoms (e.g., vegetable oils such as camellia oil, soybean oil, cottonseed oil, sesame oil, safflower oil, corn oil, coconut oil, perilla oil, and castor oil; synthetic oils such as 2-linoleoyl-1,3-dioctanoylglycerol); and ester oils such as cetyl ethylhexanoate, octyldodecyl myristate, glyceryl tri-2-ethylhexanoate (glyceryl triisooctanoate), isopropyl myristate, and glyceryl divalamethoxycinnamate-monoethylhexanoate.

[0035] These liquid oils may be used individually or in combination of two or more. Among these liquid oils, liquid hydrocarbon oils and ester oils are preferred from the viewpoint of further improving separation stability, obtaining a better moderate film-forming effect, and / or further improving the anti-stickiness effect.

[0036] The content of the oily base in the emulsified composition of the present invention is not particularly limited, but for example, it is 5 to 20% by weight, and more preferably 10 to 15% by weight.

[0037] Other ingredients The emulsifying composition of the present invention may optionally contain other components besides those mentioned above, to the extent that they do not impede the effects of the present invention, such as other surfactants (anionic surfactants, cationic surfactants, amphoteric surfactants), thickeners, other aqueous bases (monohydric lower alcohols such as ethanol and isopropanol; polyhydric alcohols, etc.), buffers, chelating agents, antioxidants, stabilizers, preservatives, fragrances, cooling agents, dispersants, wetting agents, etc. Among these other components, anionic surfactants and polyhydric alcohols are preferred from the viewpoint of further improving separation stability, obtaining a more appropriate film-like effect, and / or further improving the stickiness suppression effect.

[0038] Examples of anionic surfactants include anionic surfactants having a phosphate group, a carboxyl group, or a sulfate group, and one or more of these may be used. Among these anionic surfactants, anionic surfactants having a phosphate group are preferred from the viewpoint of further improving separation stability, obtaining a moderate film-forming effect more effectively, and / or further improving the stickiness suppression effect.

[0039] Examples of anionic surfactants having a phosphate group include polyoxyethylene (POE) alkyl ether phosphate or its salts, monoalkyl phosphate or its salts, etc. Examples of POE alkyl ether phosphate or its salts include POE lauryl ether phosphate, POE oleyl ether sodium phosphate, POE cetyl ether sodium phosphate, etc. Examples of monoalkyl phosphate or its salts include lauryl phosphate, etc. These anionic surfactants having a phosphate group can be used individually or in combination of two or more.

[0040] When the emulsifying composition of the present invention contains an anionic surfactant, the content of the anionic surfactant can be, for example, 1 to 10% by weight, preferably 2 to 8% by weight, and more preferably 3 to 6% by weight.

[0041] Examples of polyhydric alcohols include glycerin, propylene glycol, and 1,3-butylene glycol, and one or more of these can be used. Among these polyhydric alcohols, glycerin and 1,3-butylene glycol are preferred from the viewpoint of further improving separation stability, obtaining a better moderate film-forming effect, and / or further improving the stickiness suppression effect.

[0042] When the emulsifying composition of the present invention contains a polyhydric alcohol, the polyhydric alcohol content can be, for example, 4 to 20% by weight. From the viewpoint of further improving separation stability, obtaining a moderate film-like effect more effectively, and / or further improving the stickiness suppression effect, the polyhydric alcohol content is preferably 6 to 15% by weight, more preferably 8 to 12% by weight.

[0043] Formulation The properties of the emulsified composition of the present invention are not particularly limited, and include liquid, semi-solid (gel-like, paste-like), and solid forms. From the viewpoint of further enhancing the effect of improving the feel of use, the formulation form is more preferably gel-like or paste-like.

[0044] The emulsified composition of the present invention forms a cubic liquid crystal. The formation of a cubic liquid crystal can be confirmed by small-angle X-ray scattering.

[0045] The emulsion type of the emulsified composition of the present invention may be either an oil-in-water emulsion or a water-in-oil emulsion, but an oil-in-water emulsion is preferred.

[0046] The emulsified composition of the present invention can be used as an external preparation such as cosmetics, quasi-drugs for external use, and pharmaceuticals for external use. The product form of the external composition of the present invention is not particularly limited, but examples include lotions, creams, ointments, emulsions, gels, oils, liniments, and aerosols.

[0047] Purpose The emulsified composition of the present invention has excellent moderate film-forming properties and can be applied to any skin area requiring protection. Furthermore, the emulsified composition of the present invention also has excellent anti-stickiness properties, so it can be applied comfortably to areas that come into contact with clothing or other worn items, reducing soiling of the clothing. Specific areas to which the emulsified composition of the present invention can be applied include, for example, the face, neck, chest, back, arms, elbows, hands, armpits, abdomen, vulva, buttocks, anus, legs, fingers, toes, and soles of the feet. Preferably, it can be applied to the vulva, buttocks, anus, etc., and particularly preferably to the vulva.

[0048] The target users of the emulsified composition of the present invention are not particularly limited, but because the emulsified composition of the present invention has excellent moderate film-forming effect and anti-stickiness effect, it is preferably used by newborns (up to 28 days old) who are prone to diaper rash; infants (from 28 days old to under 1 year old); toddlers (from 1 year old to preschool age); women who are prone to rash from menstrual blood and / or vaginal secretions; middle-aged (around 45 years old to under 55 years old) and elderly (55 years old and over) who are prone to rash from urine, menstrual blood, and / or vaginal secretions. Among these, particularly preferred target users are middle-aged and elderly (around 45 years old and over) whose skin (especially the vulva) is easily subjected to physical and / or chemical irritation due to contact with clothing and other worn items, menstrual blood, vaginal secretions, sweat, etc.

[0049] Method for producing an emulsified composition The emulsified composition of the present invention can be prepared by mixing components (A) to (C) above, and other components as needed, in the usual order and in desired amounts, in accordance with the method for producing an emulsified composition. [Examples]

[0050] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

[0051] The emulsified compositions shown in Tables 1 and 2 were prepared. First, an oily composition was prepared by mixing predetermined amounts of an oily base (liquid paraffin, glyceryl triisooctanoate, sodium POE oleyl ether phosphate), and then adding components (A), (B), and (C), and mixing at 80°C. Separately, an aqueous composition was prepared by mixing predetermined amounts of an aqueous base (purified water, 1,3-butylene glycol, glycerin) at 80°C. These oily and aqueous compositions were then mixed at 80°C to perform an emulsification operation and prepare the emulsion compositions. The obtained emulsion compositions were evaluated as follows.

[0052] <Confirmation of Cubic Liquid Crystal Formation> The formation of cubic liquid crystals in each emulsion composition was confirmed using a small-angle X-ray scattering apparatus. Specifically, each emulsion composition was irradiated with X-rays, and the scattered X-rays emitted were detected to obtain a peak chart. The obtained peak pattern was then compared with the peak pattern characteristic of cubic liquid crystals to confirm the presence or absence of cubic liquid crystal formation in each emulsion composition.

[0053] <Separation stability> 100g of each emulsified composition was filled into a mayonnaise bottle (140mL) and stored in a dark place at 25°C for 6 months. The appearance of each emulsified composition after storage was observed, and the degree of separation stability was scored on a 10-point scale using a visual analog scale (VAS), where 10 points indicated a clear state with no separation observed (Example 1), and 1 point indicated a state where severe separation was observed and the mixture could not be made uniform even after shaking (Comparative Example 1). A score of 5 or higher was considered the desired separation stability. The results are shown in Tables 1 and 2.

[0054] <Feeling of use> Ten women (ages 25-50) were asked to apply each emulsified composition to their vulva at a dose of 2g per application. The film-forming effect and resistance to stickiness were evaluated 30 minutes after application according to the following criteria. The results are shown in Tables 1 and 2.

[0055] (membrane feeling) A five-point scale was used to rate the feeling of the film: "Not enough film-like texture," "Slightly lacking in film-like texture," "Just right film-like texture," "Slightly noticeable film-like texture," and "Noticing film-like texture." The number of people who answered "Just right film-like texture" was used as the film-like texture evaluation score.

[0056] (Suppresses stickiness) A five-point scale was used to rate the stickiness: "not sticky," "not very sticky," "neither sticky nor sticky," "slightly sticky," and "very sticky." The number of people who answered "not sticky" was used as the evaluation score for stickiness suppression.

[0057] [Table 1]

[0058] [Table 2]

[0059] As is clear from Tables 1 and 2, the combination of components (A), (B), and (C) forms a cubic liquid crystal with excellent separation stability, and furthermore, an emulsified composition with a moderate film-like feel and excellent anti-stickiness properties was obtained.

[0060] [Example prescription] Each emulsified composition shown in Tables 3 and 4 was prepared, and the formation of cubic liquid crystals, separation stability, and usability were evaluated using the same method as in the examples. In all of the emulsified compositions from Formulation Examples 1 to 15, cubic liquid crystals were formed, and both separation stability and usability were excellent.

[0061] [Table 3]

[0062] [Table 4]

Claims

1. (A) an ether-based nonionic surfactant, (B) a higher fatty acid, and (C) lidocaine are contained, The total HLB value of component (A) is 11 to 18. An emulsified composition wherein the number of carbon atoms in component (B) is 14 to 20.

2. The emulsifying composition according to claim 1, wherein component (A) is a polyoxyalkylene alkyl ether, a polyoxyalkylene alkenyl ether, and / or a polyoxyalkylene steryl ether.

3. The emulsifying composition according to claim 1 or 2, wherein the component (A) is a polyoxyalkylene alkyl ether and a polyoxyalkylene alkenyl ether.

4. The emulsified composition according to any one of claims 1 to 3, wherein the content of component (A) is 3 to 25% by weight.

5. The emulsified composition according to any one of claims 1 to 4, wherein the content of component (B) is 0.1 to 1 part by weight per 1 part by weight of component (A).

6. The emulsified composition according to any one of claims 1 to 5, wherein the content of component (C) is 0.05 to 0.5 parts by weight per 1 part by weight of component (A).

7. An emulsified composition according to any one of claims 1 to 6, to be applied to the external genitalia.

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