EphA2-specific bicyclic peptide ligand
Bicyclic peptides covalently linked to a non-aromatic scaffold address the specificity and stability challenges of EphA2-targeting therapeutics, enhancing treatment efficacy and safety for EphA2-overexpressing diseases.
JP7884036B2Active Publication Date: 2026-07-02BICYCLETX LTD
Patent Information
- Application Number
- JP2024093609
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2018-11-14
- Filing Date
- 2024-06-10
- Publication Date
- 2026-07-02
- Estimated Expiration
- 2038-12-19
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Figure 0007884036000141 
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Abstract
To provide bicyclic peptide ligands specific to EphA2.SOLUTION: Provided herein is a EphA2 specific peptide ligand comprising a polypeptide comprising at least three cysteine residues separated by at least two loop sequences, and a non aromatic molecular scaffold covalently linked to the cysteine residues of the polypeptide to form at least two polypeptide loops on the scaffold, having an amino acid sequence Ci(HyP)LVNPLCiiLHP(D-Asp)W(HArg)Ciii (SEQ ID NO:1) where HyP is hydroxyproline, Harg is homoarginine, and Ci, Cii and Ciii are the first, second and third cysteine residues respectively.SELECTED DRAWING: None
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Citation Information
Patent Citations
Method and composition
JP2011514803A
Polypeptide modification
JP2016527180A
JPP7293231B