Composition

Abstract

To suppress crystal deposition in a composition comprising niacinamide and tranexamic acid.SOLUTION: There is provided a composition which comprises the following components (A) to (C): (A) niacinamide, (B) tranexamic acid, (C) one or two or more selected from the group consisting of an extracts and a fermented product of a plant belonging to Poaceae family, Nelumbonaceae family, Rosaceae family, Malvaceae family, Compositae family or Leguminosae family.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a composition.

Background Art

[0002] Maintaining healthy and beautiful skin is a highly concerned issue for many people. The skin can cause various problems such as rough skin, wrinkles, sagging, and pigmentation due to various factors such as ultraviolet rays, dryness, aging, and stress. In order to improve these skin problems in a multifaceted manner, it is considered effective to apply multiple components with different actions to the skin.

[0003] For example, niacinamide, which is one type of vitamin, has effects on the skin such as wrinkle improvement effect, improvement of skin barrier function, whitening effect, and improvement of skin texture (see, for example, Non-Patent Document 1). Tranexamic acid has an anti-inflammatory effect, so it is used as an active ingredient of a pharmaceutical product and is also known to have an effect of suppressing melanin production (see, for example, Patent Document 1). A composition containing these two components with different actions is expected to bring multifaceted effects on multiple skin problems.

[0004] On the other hand, it is known that compositions containing niacinamide or tranexamic acid alone precipitate crystals over time. Regarding tranexamic acid, a topical skin preparation containing 0.1 to 5% by mass of tranexamic acid, 0.01 to 5% by mass of a long-chain acyl sulfonate type anionic surfactant, and a higher alcohol and adjusted to a pH of 3 to 6 prevents crystal precipitation of tranexamic acid (see, for example, Patent Document 2).

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Non-Patent Documents

[0006] [Non-Patent Document 1] Cosmeceuticals and Cosmetic practice Chap.10.2014 page 103-112 [Overview of the project] [Problems that the invention aims to solve]

[0007] Conventionally, compositions containing high concentrations of niacinamide or tranexamic acid have suffered from significant crystal precipitation, and when the composition adheres to the dispensing nozzle or lid of a container during use, crystals precipitate, posing a problem. However, no research has been conducted to date on suppressing crystallization in compositions containing both niacinamide and tranexamic acid. The present invention aims to solve the problem of finding that crystal precipitation in compositions containing niacinamide and tranexamic acid is more severe than in compositions where each component was present alone. [Means for solving the problem]

[0008] To solve this problem, the inventors conducted diligent research and found that including one or more plants selected from the group consisting of extracts and fermented products of plants belonging to the grass family, lotus family, rose family, mallow family, daisy family, or legume family in a niacinamide and tranexamic acid formulation exhibits a crystal precipitation inhibitory effect.

[0009] In other words, the present invention comprises the following components (A) to (C); (A) Niacinamide (B) Tranexamic acid (C) One or more selected from the group consisting of extracts and fermented products of plants belonging to the grass family, lotus family, rose family, mallow family, daisy family, or legume family. This relates to a composition containing [the specified substance]. [Effects of the Invention]

[0010] The present invention provides a composition containing niacinamide and tranexamic acid that inhibits crystallization, a crystallization inhibitor, and a cosmetic or topical skin preparation. [Brief explanation of the drawing]

[0011] [Figure 1] In the embodiments of the present invention, this is judged as "◎". [Figure 2] In the embodiments of the present invention, this is determined to be "○". [Figure 3] In the embodiments of the present invention, this is judged as "×". [Modes for carrying out the invention]

[0012] The present invention will be described in detail below. In this specification, "~" means a range including the numbers before and after it.

[0013] Ingredient (A): Niacinamide In this invention, component (A), niacinamide, is an amide of nicotinic acid (vitamin B3 / niacin). Niacinamide is a water-soluble vitamin and a known substance that is one of the B vitamins. It can be extracted from natural products (such as rice bran) or synthesized by known methods. Specifically, the niacinamide listed in the 15th edition of the Japanese Pharmacopoeia 2008 can be used.

[0014] The content of component (A) is not particularly limited, but from the viewpoint of suppressing crystal precipitation, it is preferably 1 to 10% by mass (hereinafter simply abbreviated as "%"), more preferably 3 to 8%, and even more preferably 4 to 7%.

[0015] Ingredient (B): Tranexamic acid Tranexamic acid, which is the component (B) used in the present invention, is a kind of amino acid represented by trans-4-(aminomethyl)cyclohexane-1-carboxylic acid. Tranexamic acid may be used for its whitening effect and anti-inflammatory effect on the skin, and may also be used as a hemostatic agent.

[0016] The content of the component (B) is not particularly limited, but from the viewpoint of the crystal precipitation inhibitory effect, it is preferably 1 to 7%, more preferably 1.3 to 6%, and even more preferably 1.5 to 5%.

[0017] Component (C): One or more selected from the group consisting of extracts and fermented products of plants belonging to the family Poaceae, Scirpaceae, Rosaceae, Malvaceae, Asteraceae, or Fabaceae

[0018] The term "grasses" refers to all plants belonging to the family Poaceae (Gramineae). Major genera of grasses include Phyllostachys, Oryza, Avena, Sorghum, Saccharum, Coix, and Sasa, but any of these can be used, and their origin and harvesting time are not particularly limited. The part used is also not particularly limited, including roots, rhizomes, stems, leaves, flowers, fruits, and seeds, but using seeds is especially preferred. Specific plants include, but are not limited to, Phyllostachys bambusoides Siebold et Zucc., Oryza sativa L., Avena fatua L., Sorghumbicolar Moench var. bicolor, Saccharum spontaneum L. var. arenicola Ohwi, Sasa veitchii Rehder, Coix lachrymal-jobi L., and Coix lachrymal-jobi L. Among these, one or more species selected from the group consisting of the genera Oryza and Coix lachrymal-jobi are preferred, and one or more species selected from the group consisting of Oryza sativa, Coix lachrymal-jobi, and Coix lachrymal-jobi are more preferred.

[0019] Plants belonging to the Nelumbonaceae family include all plants belonging to the Nelumbonaceae family. The main genera of the Nelumbonaceae family include the Nelumbo genus, etc. Any of these can be used, and their place of origin and collection time are not particularly limited. Specific plants include Nelumbo nucifera Gaertner, Euryale ferox Salisb, Victoria amazonica, Nelumbo spec., Nelumbo nucifera cv. Ouren, Nelumbo nucifera cv. Benimaihiren, Nelumbo lutea, Nelumbo hybrida, etc. Any of these can be used, and their place of origin and collection time are not particularly limited. The part used is not particularly limited either, such as roots, rhizomes, stems, leaves, flowers, fruits, seeds, etc., but it is particularly preferable to use seeds. Specific plants are not particularly limited, but examples include Nelumbo nucifera. Among these, one or more selected from the group consisting of the Nelumbo genus are preferable, and Nelumbo nucifera is more preferable.

[0020] Plants belonging to the Rosaceae family include all plants belonging to the Rosaceae family. The main genera of the Rosaceae family include the Rosa genus, Rubus genus, Malus genus, Spiraea genus, Crataegus genus, Pyrus genus, etc. Any of these can be used, and their place of origin and collection time are not particularly limited. The part used is not particularly limited either, such as roots, rhizomes, stems, leaves, flowers, fruits, seeds, etc., but it is particularly preferable to use fruits. Specific plants are not particularly limited, but examples include Malus domestica and Pyrus communis. Among these, one or more selected from the group consisting of the Rosa genus, Rubus genus, Malus genus, and Pyrus genus are preferable, one or more selected from the group consisting of the Malus genus and Pyrus genus are more preferable, and one or more selected from the group consisting of Malus domestica and Pyrus communis are even more preferable.

[0021] The Malvaceae family encompasses all plants belonging to the Malvaceae family. Major genera within the Malvaceae family include, for example, the Hibiscus and Malva genera. While the parts used are not particularly limited to roots, rhizomes, stems, leaves, flowers, fruits, and seeds, the use of flowers is particularly preferred. Specific examples of plants include, but are not particularly limited, hibiscus (Hibiscus sabdariffa). Among these, one or more species selected from the Hibiscus genus are preferred, and one or more species selected from the Hibiscus group are even more preferred.

[0022] The term "plants belonging to the Asteraceae family" encompasses all plants belonging to this family. Major genera within the Asteraceae family include Chrysanthemum, Matricaria, Centaurea, Ambrosia, and Artemisia, but any of these can be used, and their origin and harvesting time are not particularly limited. The part of the plant used is also not particularly limited, including roots, rhizomes, stems, leaves, flowers, fruits, and seeds, but using the flowers is especially preferred. Specific examples of plants include chamomile and cornflower, although these are not particularly limited. Among these, one or more species selected from the group consisting of the genera Chrysanthemum, Chrysanthemum, Cornflower, and Artemisia are preferred, one or more species selected from the group consisting of Chrysanthemum and Cornflower are more preferred, and one or more species selected from the group consisting of Chamomile and Cornflower are even more preferred.

[0023] Plants belonging to the Fabaceae family include all plants belonging to this family. The main genera of the Fabaceae family include Glycine, Arachis, Aspalathus, and Pisum, but any of these can be used, and their origin and harvesting time are not particularly limited. The part used is also not particularly limited, including roots, rhizomes, stems, leaves, flowers, fruits, and seeds, but the use of seeds is particularly preferred. Specific examples of plants include soybeans (Glycine max), although these are not particularly limited. Among these, one or more species selected from the group consisting of the Glycine genus are preferred, and one or more species selected from the group consisting of soybeans are more preferred.

[0024] Extracts from the above plants can be prepared, for example, as follows: First, the extraction part of each plant is washed with water if necessary to remove foreign matter, then either left as is or dried, and if necessary, finely chopped or pulverized, and then brought into contact with the extraction solvent for extraction. Extraction can be carried out by contacting the extraction solvent according to conventional methods such as immersion, but supercritical fluid extraction or steam distillation can also be used.

[0025] Examples of extraction solvents include water; lower alcohols such as methanol, ethanol, and propanol; higher alcohols such as oleyl alcohol, stearyl alcohol, and octyldodecanol; polyhydric alcohols such as ethylene glycol, 1,3-propanediol, 1,3-butylene glycol, and glycerin; esters such as ethyl acetate, butyl acetate, methyl propionate, and glyceryl trioctanoate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; and hydrocarbon solvents such as n-hexane, toluene, and chloroform. These can be used individually or in combination of two or more.

[0026] When using a mixed solvent, the mixing ratio is preferably in the range of 1:1 to 25:1 by volume (hereinafter the same) for a mixed solvent of water and ethyl alcohol, 1:1 to 15:1 for a mixed solvent of water and glycerin, and 1:1 to 15:1 for a mixed solvent of water and 1,3-propanediol or 1,3-butylene glycol.

[0027] While there are no particular limitations on the pH of the extract during preparation, it is generally preferable to have a pH in the range of 3 to 9. In this sense, if necessary, the extraction solvent may be mixed with an alkaline adjusting agent such as sodium hydroxide, sodium carbonate, or potassium hydroxide, or an acidic adjusting agent such as citric acid, hydrochloric acid, phosphoric acid, or sulfuric acid to adjust the pH to the desired level.

[0028] Extraction conditions such as extraction temperature and extraction time vary depending on the type of solvent and pH used. For example, when using water, 1,3-butylene glycol, or a mixture of water and 1,3-butylene glycol as the solvent, the extraction temperature is preferably in the range of 0°C to 90°C, and the extraction time is preferably 15 minutes to 10 days.

[0029] Furthermore, in the present invention, fermentation treatment using microorganisms (such as lactic acid bacteria, yeast, koji mold, or Bacillus subtilis) may be performed for the purpose of improving the effectiveness of the extracted material, suppressing skin irritation, or improving its stability.

[0030] Fermentation can be carried out, for example, as follows: First, the plant itself (hereinafter sometimes referred to as "plant body") may be used as the source of fermentation, or an extract obtained by extracting the plant body with an appropriate medium may be used. Furthermore, when using an extract, it is possible to carry out fermentation with the plant body still included, without removing the plant body by solid-liquid separation. Here, the plant may be fresh, or it may be pre-dried or semi-dried. In terms of form, it is also possible to use the plant as it was collected.

[0031] In this invention, lactic acid bacteria refer to lactic acid bacteria of the genus Lactobacillus, such as Lactobacillus plantarum, Lactobacillus brevis, Lactobacillus casei, and Lactobacillus delbrueckii; lactic acid bacteria of the genus Carnobacterium, such as Carnobacterium divergens and Carnobacterium piscicola; and Leuconostoc mesenteroides, Leuconostoc lactis, and Leuconostoc citreum. Lactic acid bacteria of the genus Leuconostoc, such as *Leuconostoc citreum*; lactic acid bacteria of the genus Streptococcus, such as *Streptococcus faecalis* and *Streptococcus pyogenes*; lactic acid bacteria of the genus Enterococcus, such as *Enterococcus caseliflavus* and *Enterococcus sulfreus*; lactic acid bacteria of the genus Lactococcus, such as *Lactococcus plantarum* and *Lactococcus rafinolactis*; lactic acid bacteria of the genus Weissella, such as *Weissella confusa* and *Weissella kandleri*; Atopovium Lactobacillus species of the genus Atopobium, such as Atopobium minutum and Atopobium parvulus;Examples include lactic acid bacteria of the genus Vagococcus, such as Vagococcus fluvialis and Vagococcus salmoninarum; and lactic acid bacteria of the genus Pediococcus, such as Pediococcus damnosus and Pediococcus pentosaceus. Among these, one or more species selected from the group consisting of Lactobacillus plantarum and Lactobacillus delbrueckii are preferred.

[0032] Furthermore, in this invention, yeast refers to, for example, yeasts of the genus Saccharomyces such as Saccharomyces cerevisiae, Saccharomyces awamori, Saccharomyces chevalieri, Saccharomyces carlsbergensis, and Saccharomyces bayonus; yeasts of the genus Galactomyces; yeasts of Schizosaccharomyces such as Schizosaccharomyces pombe; Torulaspora delbruekii, Torulaspora fermentati, and Torulaspora rosai. Yeasts of the genus Torraspora, such as rosei; yeasts of the genus Zygosaccharomyces, such as Zygosaccharomyces rouxii, Zygosaccharomyces soya, Zygosaccharomyces sake, Zygosaccharomyces miso, Zygosaccharomyces lactis; Candida versatilis, Candida etchellsii, Candida kefyr, Candida sake, Candida scotti (Candida Examples include yeasts of the genus Candida, such as Candida scottii, and yeasts of the genus Aureobasidium, such as Aureobasidium pullulans, Aureobasidium mansonii, and Aureobasidium microstictum.Furthermore, the yeast according to the present invention may be any of the following: sake yeast, wine yeast, beer yeast, yeast derived from plant flowers (roses, lilies, cherry blossoms, etc.), or yeast derived from the sea. Among these, Saccharomyces cerevisiae is preferred.

[0033] In the present invention, koji mold refers to, for example, yellow koji mold such as Aspergillus oryzae, Aspergillus flavus, Aspergillus polyoxogenes, and Aspergillus sojae; black koji mold such as Aspergillus awamori, Aspergillus kawauchii, Aspergillus usami, and Aspergillus niger; and red koji mold such as Monascus anka and Monascus pilosus. Among these, Aspergillus oryzae is preferred.

[0034] In the present invention, the content of component (C) is not particularly limited, but from the viewpoint of suppressing crystal precipitation, it is preferably 0.0001 to 0.5% as the purity of the extract, more preferably 0.0002 to 0.1%, and even more preferably 0.0005 to 0.05%. In the present invention, "extract" refers to an extract or fermented product, and "purity of the extract" refers to the evaporation residue remaining after evaporating the solvent in the extract.

[0035] In the present invention, the mass ratio (A) / (C) of component (A) to component (C) is not particularly limited, but from the viewpoint of suppressing crystal precipitation, it is preferably 300 or more, more preferably 500 or more, and even more preferably 1000 or more. Furthermore, it is preferably 16000 or less, more preferably 13000 or less, and even more preferably 10000 or less.

[0036] In the present invention, the mass ratio (B) / (C) of component (B) to component (C) is not particularly limited, but from the viewpoint of suppressing crystal precipitation, it is preferably 300 or more, more preferably 400 or more, and even more preferably 500 or more. Furthermore, it is preferably 6000 or less, more preferably 4000 or less, and even more preferably 2000 or less.

[0037] In the present invention, the mass ratio of the total amount of components (A) and (B) to component (C), [(A)+(B)] / (C), is not particularly limited, but from the viewpoint of suppressing crystal precipitation, it is preferably 700 or more, more preferably 1000 or more, and even more preferably 1400 or more. Furthermore, it is preferably 22000 or less, more preferably 18000 or less, and even more preferably 14000 or less.

[0038] The present invention may further contain component (D) phosphate. The salt is not particularly limited, including organic salts and inorganic salts, but from the viewpoint of adjusting the pH of the composition and providing a buffering effect, an inorganic salt is preferred, and a sodium salt is particularly preferred. By including phosphate in the present composition, it is expected that it will be stably present in compositions containing both components (A) and (B). Component (D) phosphate in the present invention may be used alone or in combination of two or more types, for example, monosodium hydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, etc. are preferably used. Among these, one or more selected from the group consisting of monosodium hydrogen phosphate and disodium hydrogen phosphate are preferred, and it is more preferable to include monosodium hydrogen phosphate and disodium hydrogen phosphate.

[0039] The content of component (D) in the present invention is not particularly limited, but it is preferably 0.01% or more, more preferably 0.05% or more, and even more preferably 0.1% or more in the composition. Furthermore, it is preferably 1% or less, more preferably 0.5% or less, and even more preferably 0.3% or less. Within this range, it is more preferable because it provides superior crystal precipitation suppression.

[0040] The present invention may further contain component (E) sugar alcohol. In the present invention, the addition of sugar alcohol is more preferable because it provides a superior effect in suppressing crystal precipitation. In the present invention, the sugar alcohol is not particularly limited, and any of them can be used. For example, erythritol, sorbitol, mannitol, maltitol, xylitol, galactitol, arabitol, trehalose, pentaerythritol, etc., can be used in combination of one or more of these. Among these, one or more selected from the group consisting of erythritol, sorbitol, mannitol, and maltitol are preferred, one or more selected from the group consisting of erythritol, sorbitol, and maltitol are more preferred, and one or more selected from the group consisting of erythritol and sorbitol are even more preferred.

[0041] In the present invention, the content of component (E) is not particularly limited, but it is preferably 0.1% or more, more preferably 0.2% or more, and even more preferably 0.3% or more in the composition. Furthermore, it is preferably 5% or less, more preferably 3% or less, and even more preferably 2% or less. Within this range, it is more preferable because it provides superior crystal precipitation suppression.

[0042] Furthermore, the composition containing components (A) to (E) of the present invention may, if necessary, contain components commonly used in various formulations such as cosmetics, quasi-drugs, and pharmaceuticals for topical use on the skin, to the extent that the effects of this technology are not impaired. Examples of such components include water, oils, surfactants, metal soaps, gelling agents, powders, alcohols, water-soluble polymers, film-forming agents, resins, UV protection agents, inclusion compounds, antibacterial agents, fragrances, deodorants, pH adjusters, cooling agents, animal and microbial extracts, plant extracts, blood circulation promoters, astringents, anti-seborrheic agents, whitening agents, anti-inflammatory agents, free radical scavengers, cell activators, moisturizers, chelating agents, keratolytic agents, enzymes, hormones, vitamins, and the like. One or more of these may be appropriately selected and used.

[0043] The present invention is not particularly limited as long as it can contain water and is used in various formulations such as cosmetics, quasi-drugs, pharmaceuticals, and other topical skin preparations. The water may be purified water, hot spring water, deep sea water, or steam-distilled water from plants, and one or more of these may be appropriately selected and used as needed. The water content is not particularly limited, but is preferably 10-99%, and more preferably 20-95%.

[0044] The composition containing components (A) to (E) of the present invention can be obtained by known manufacturing methods. The manufacturing method is not particularly limited, but for example, it can be obtained by dissolving components (A), (B), and (D) in water, and then adding and mixing components (C) and (E).

[0045] The composition of the present invention is not particularly limited, but is preferably a cosmetic or a topical skin preparation. Specifically, as a cosmetic or topical skin preparation, it may take any of the following forms: basic cosmetics such as lotions, creams, toners, serums, packs, all-in-one gels, sunscreens, and cleansers; makeup cosmetics such as makeup bases, BB creams, foundations, blushes, and lipsticks; hair cosmetics such as hair tonics, hair tonics, shampoos, and conditioners; dispersions, ointments, liquids, aerosols, patches, poultices, and liniments. It is preferable that the composition is a cosmetic or topical skin preparation used on the skin, with the expectation of whitening effects, emollient effects, etc.

[0046] The composition containing components (A) to (E) of the present invention is not particularly limited, but is preferably a crystal precipitation inhibitor. As a crystal precipitation inhibitor, it can be used in cosmetics, quasi-drugs, pharmaceuticals and other topical skin preparations, oral preparations, injectable preparations, etc., and is particularly preferred for use in cosmetics and topical skin preparations applied to the skin. [Examples]

[0047] The present invention will be described in more detail below with reference to examples, but the present invention is not limited thereto.

[0048] Examples 1-20 and Comparative Example 1: Lotion Lotions were prepared according to the formulations shown in Tables 1-3 below. The crystal precipitation inhibition effect was evaluated for each sample (Examples 1-20, Comparative Example 1) using the evaluation method described below. The results are also shown in Tables 2-3.

[0049] (Evaluation criteria) I. Effect of suppressing crystal precipitation

[0050] [I. Evaluation of the effect of suppressing crystal precipitation] To evaluate the crystal precipitation suppression effect, 3g of each sample (Examples 1-20, Comparative Example 1, Reference Examples 1-20) was applied to a 3cm diameter polystyrene dish (product name: Falcon cell culture dish, manufactured by CORNING, Inc.), and after air-drying at room temperature for 3 days, the area of ​​precipitated crystals in each sample (Examples 1-20, Comparative Example 1, Reference Examples 1-20) was measured. The improvement rate of Example X or Comparative Example X was calculated using the following formula (1), and the evaluation was made according to the following criteria.

[0051] Improvement rate (%) in Example X or Comparative Example X = 100 × [(Area of ​​precipitated crystals in Reference Example X) - (Area of ​​precipitated crystals in Example X or Comparative Example X)] / (Area of ​​precipitated crystals in Reference Example X) ... Equation (1) Here, X represents the number of the example, comparative example, or reference example.

[0052] <Judgment criteria> (Judgment): (Evaluation) ◎: Improvement rate exceeds 40% ○: The improvement rate is over 20% and 40% or less. ×: The improvement rate is 20% or less.

[0053] [Table 1] [Table 2] [Table 3]

[0054] (Manufacturing method) A: Ingredients 1-18 were uniformly dissolved and mixed at 60°C, and then cooled to room temperature to obtain a lotion.

[0055] As is clear from the results in Tables 2-3, the lotions of Examples 1-20 were excellent in their crystal precipitation inhibitory effect. On the other hand, Comparative Example 1, which did not contain component (C), was not excellent in its crystal precipitation inhibitory effect.

[0056] Example 21: Oil-in-water emulsion (Ingredients) (%) 1,1,3-Butylene glycol 12.0 2. Tranexamic acid 4.0 3. Purified water remaining amount 4. Niacinamide 6.0 5. Polyethylene glycol monostearate (40 E.O.) 0.5 6. Sorbitan sesquioleate 0.1 7. Hydrogenated lecithin 0.1 8. Cholesteryl hydroxystearate (Note 1) 3.0 9. Vaseline 2.0 10. α-olefin oligomer 5.0 11. Shea butter 2.0 12. Dimethylpolysiloxane (10CS) 1.0 13. Ceramide 3 0.1 14. Astaxanthin 0.1 15. Tocopherol 0.01 16. Cetostearyl alcohol 2.0 17. Behenyl alcohol 1.0 18. Methyl parahydroxybenzoate 0.1 19. Acrylic acid / alkyl methacrylate copolymer (Note 2) 0.1 20. Xanthan gum 0.1 21. Sodium hydroxide 0.03 22. Hibiscus flower fermented liquid (pure content: 1%) 0.1 23.Fragrance 0.2 Note 1) Saracos HS (manufactured by Nisshin Oillio Co., Ltd.) Note 2) Carbopol ULTREZ 21 (manufactured by Lubriol)

[0057] (Manufacturing method) A: Dissolve and mix components 1-4 uniformly at 70°C. B: Dissolve and mix components 5-17 uniformly at 80°C. Add B to C:A and emulsify at 70°C. After adding components 18-23 to D:C and mixing, the mixture was cooled to 40°C to obtain an oil-in-water emulsion.

[0058] The oil-in-water emulsion of Example 21 demonstrated excellent crystal precipitation suppression.

[0059] Example 22: Oil-in-water emulsion beauty serum (Ingredients) (%) 1,1,3-Butylene glycol 5.0 2. Tranexamic acid 3.0 3. Tripropylene glycol 3.0 4. Purified water remaining amount 5. Niacinamide 1.0 6. Polyoxyethylene sorbitan monooleate (20 E.O.) 0.1 7. Polyethylene glycol monostearate (55 E.O.) 0.25 8. Macadamia nut oil fatty acid phytosteryl (Note 3) 2.0 9. Light liquid isoparaffin (Note 4) 3.0 10. Dimethylpolysiloxane (6CS) 3.0 11. Cholesterol 0.1 12. Tocopherol 0.01 13. Cetostearyl alcohol 0.5 14. Methyl parahydroxybenzoate 0.1 15. Carbomer (Note 5) 0.15 16. (Sodium acrylate / sodium acryloyldimethyl taurate) Copolymer (Note 6) 0.1 17. Sodium hydroxide 0.05 18. Ethanol 5.0 19. Collagen 0.1 20. Elastin 0.1 21. Hyaluronic acid 0.1 22. Chamomile flower extract (pure content: 1%) 0.05 23. Cornflower extract (pure content: 1%) 0.05 24.Fragrance 0.05 Note 3) PLANDOOL-MAS (manufactured by Nippon Seika Co., Ltd.) Note 4) Chloratum LES (manufactured by Croda) Note 5) CARBOPOL980 (manufactured by LUBURIZOL) Note 6) SIMULGEL EG (manufactured by SEPIC)

[0060] (Manufacturing method) A: Dissolve and mix components 1-4 uniformly at 70°C. B: Dissolve and mix components 5-12 uniformly at 80°C. Add B to C:A and emulsify at 70°C. After adding ingredients 13-24 to D:C and mixing, the mixture was cooled to 40°C to obtain an oil-in-water emulsion beauty serum.

[0061] The oil-in-water emulsion serum of Example 22 demonstrated excellent crystal precipitation suppression.

[0062] Example 23: Liquid hair serum (Ingredients) (%) 1. Oleic acid 0.15 2. Ethyl oleate 0.2 3. Tocopherol acetate 0.02 4. Menthol 0.5 5. Methyl parahydroxybenzoate 0.1 6. Vinyl acetate / vinylpyrrolidone copolymer (Note 7) 0.1 7.Fragrance 0.2 8. Polyoxyethylene (20 mol) hydrogenated castor oil 0.3 9. Ethanol 50.0 10. Alkyl-modified carboxyvinyl polymer 0.1 11. Carboxyvinyl polymer 0.1 12,2-amino-2-methylpropanol 0.05 13. Niacinamide 4.0 14. Tranexamic acid 4.0 15. Rice fermentation liquid (pure content: 2%) 0.03 16. Rice extract (pure content: 1%) 0.02 17. Hydrolyzed rice extract (pure content: 1%) 0.02 18. Purified water remaining amount (Note 7) Acorn KS (manufactured by Osaka Organic Chemical Industry Co., Ltd.)

[0063] (Manufacturing method) A: Mix ingredients 1-9 together. B: Mix ingredients 10-18. A was added to CB and mixed to obtain a liquid hair serum.

[0064] The liquid hair serum obtained in Example 23 exhibited excellent crystal precipitation suppression effects.

[0065] Example 24: Sheet-type cosmetic pack (Ingredients) (%) 1. Isostearic acid 0.05 2. Polyoxyethylene (60 mol) hydrogenated castor oil 0.3 3. 2-Ethylhexyl Methoxycinnamate 0.05 4. Glycerin 3.0 5.1,3-Butylene glycol 5.0 6. Ethanol 8.0 7. Sodium citrate 0.02 8. Citric acid 0.05 9. Dipotassium glycyrrhizinate 0.1 10. Phenoxyethanol 0.05 11. Niacinamide 4.0 12. Tranexamic acid 2.0 13. 40% aqueous solution of pentasodium diethylenetriaminepentaacetate 0.15 14. Soy milk fermented liquid (pure content: 3%) 0.05 15. Purified water remaining amount

[0066] (Manufacturing method) A: Mix and dissolve ingredients 1-6. Mix and dissolve ingredients B:7-15. Add C:A to B and mix. D:C was impregnated into a nonwoven fabric to obtain a sheet-like cosmetic pack.

[0067] The sheet-type cosmetic pack of Example 24 exhibited excellent crystal precipitation suppression effects.

[0068] Example 25: Ointment (Ingredients) (%) 1. Triethanolamine 2.0 2. Glycerin 8.0 3. Purified water remaining amount 4. Niacinamide 3.0 5. Tranexamic acid 4.0 6. Rice fermentation liquid (pure content: 2%) 0.03 7. Rice extract (pure content: 1%) 0.02 8. Cetanol 4.0 9. Vaseline 30.0 10. Tocopherol 0.01 11. Stearic acid 18.0 12. Sorbitan sesquioleate 1.5

[0069] (Manufacturing method) A. Dissolve components (8) to (12) uniformly at 75°C. B. Dissolve components (1) to (7) uniformly at 75°C. B was gradually added to CA, emulsified at 75°C, and cooled to room temperature to obtain an ointment.

[0070] The ointment of Example 25 showed excellent effect in inhibiting crystal precipitation.

[0071] Example 26: Foundation (Ingredients) (%) 1. PEG-9 Polydimethylsiloxyethyl Dimethicone 1.2 2. Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 0.5 3. Isododecane 25.0 4. (PEG-15 / Lauryl Dimethicone) Crosspolymer 0.1 5. Isotridecyl isononanoate 6.0 6. Trifluoroalkyldimethylsiloxysilicate 2.0 7. Dimelpolysiloxane (kinematic viscosity at 25°C: 20 CS) 0.5 8. Ethylhexyl Methoxycinnamate 5.0 9. Dextrin palmitate 0.1 10. Triethoxycaprylylsilane 3% treated titanium dioxide (Average particle size 30nm) 6.0 11. Titanium dioxide treated with 3% isopropyl titanium triisostearate. (Average particle size 250nm) 7.0 12. Disodium Stearoyl Glutamate 2% Red Iron Ore 0.6 13. Dimethylpolysiloxane 2% treated yellow iron oxide 1.2 14. 2% dextrin palmitate treated black iron oxide 0.4 15. Distearyldimonium hectorite 1.0 16. Stearalkonium hectorite 1.0 17. Silica (spherical, non-porous, average particle size 10 μm) 0.5 18. Purified water remaining amount 19. Xanthan gum 0.002 20. Ethanol 8.0 21.1,3-Butylene glycol 0.1 22. Sodium monohydrogen phosphate 0.01 23. Sodium dihydrogen phosphate 0.01 24. Sorbitol 0.2 25. Maltitol 0.4 26. Sodium Chloride 0.3 27. Niacinamide 2.0 28. Tranexamic acid 6.0 29. Rice fermentation liquid (pure content: 2%) 0.05 30. Tremella fuciformis polysaccharide 3.0

[0072] (Manufacturing method) A. Mix ingredients (1) to (9) uniformly at 80°C. Add ingredients (10) to (17) to BA and mix uniformly at room temperature. C. Mix components (18) to (30) uniformly at 60°C. Gradually add C to DB and emulsify at room temperature. The ED was filled into a dispenser container to obtain the foundation.

[0073] The foundation in Example 26 exhibited excellent crystal precipitation suppression effects.

[0074] Example 27: Sunscreen (water-in-oil emulsion) (Ingredients) (%) 1. Stearic acid / aluminum hydroxide treated titanium dioxide microparticles 5.0 2. Hydrogen dimethicone treated zinc oxide microparticles 15.0 3. Polyhydroxystearic acid 2.0 4. Isononyl isononanoate 10.0 5. Isopropyl palmitate 8.0 6. PEG-30 Dipolyhydroxystearate 1.0 7. PEG-9 Dimethicone 2.0 8. Cyclopentasiloxane 10.0 9. Purified water remaining amount 10. Niacinamide 4.5 11. Tranexamic acid 3.0 12.1,3-Butylene glycol 3.0 13. Glycerin 4.0 14. Sodium hyaluronate 1.0 15. Apple fruit extract (2% pure content) 0.05

[0075] (Manufacturing method) A: Mix components (1) to (4) and disperse them in a roll mill at 25°C. B: Mix components (5) to (8), add A, and mix and disperse at 25°C. C: Components (9) to (15) were uniformly mixed and added to B, and emulsified at 25°C to obtain a sunscreen (water-in-oil emulsion).

[0076] The sunscreen (water-in-oil emulsion) of Example 27 exhibited excellent crystal precipitation suppression effects. [Industrial applicability]

[0077] This invention can be applied to cosmetics, quasi-drugs, topical skin preparations, and the like.

Claims

1. The following components (A) to (D): (A) Niacinamide 1-10% by mass (B) Tranexamic acid 1-7% by mass (C) One or more selected from the group consisting of lotus seed ferment extract, soy milk ferment filtrate, cornflower extract, hibiscus flower ferment filtrate, and hibiscus flower extract. (D) Phosphate A composition containing the following:

2. The composition according to claim 1, wherein the mass ratio of component (A) to component (C), (A) / (C), is 300 to 16000.

3. The composition according to claim 1 or 2, wherein the mass ratio of component (B) to component (C) (B) / (C) is 300 to 6000.

4. The composition according to any one of claims 1 to 3, wherein the total amount of components (A) and (B) relative to component (C) is [(A) + (B)] / (C) which is 700 to 22000.

5. Furthermore, the composition according to any one of claims 1 to 4, further comprising component (E) sugar alcohol.

6. The composition according to any one of claims 1 to 5, wherein the composition is a crystal precipitation inhibitor.

7. The composition according to any one of claims 1 to 6, wherein the composition is a cosmetic or a topical skin preparation.

8. The following components (A) to (C) and (E); (A) Niacinamide 1-10% by mass (B) Tranexamic acid 1-7% by mass (C) One or more selected from the group consisting of lotus seed ferment extract, soy milk ferment filtrate, cornflower extract, hibiscus flower ferment filtrate, and hibiscus flower extract. (E) One or more sugar alcohols selected from the group consisting of erythritol, sorbitol, mannitol, and maltitol. A composition containing the following:

9. A method for inhibiting crystal precipitation, characterized by blending one or more ingredients selected from the group consisting of (C) lotus seed ferment extract, soy milk ferment filtrate, pear juice ferment filtrate, chamomile flower extract, cornflower extract, coix seed extract, hibiscus flower ferment filtrate, hibiscus flower extract, apple fruit extract, and honeysuckle flower extract, into a composition containing (A) niacinamide 1 to 10% by mass and (B) tranexamic acid 1 to 7% by mass.

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