Crosslinked composition and its use

Abstract

The present invention relates to chemical processes and more particularly to chemical processes and methods for forming crosslinked compositions.

Description

[Technical Field]

[0001] This application claims priority to U.S. Provisional Application No. 63 / 007,490, filed on 9 April 2020, the contents of which are incorporated herein by reference.

[0002] The present invention relates to a chemical process, more specifically to a chemical process and method for forming a crosslinked composition. [Background technology]

[0003] In the food, personal care, and pharmaceutical industries, a wide variety of compounds and materials are used in formulations. A broad range of stabilizers, excipients, lubricants, binders, quality improvers, fillers, colorants, etc., are known and applied to the formulation of food, personal care products, and pharmaceuticals. Examples of such materials are inorganic compounds or elements, which are widely used in the food, personal care, and pharmaceutical industries. It is common to use several different active and inactive components with significantly different physical and chemical properties in a formulation. For example, in some applications, an active component is formulated together with one or more inactive components such as stabilizers, excipients, lubricants, binders, quality improvers, fillers, and colorants. In some applications, the physical properties of the various components in a formulation can differ significantly. For example, some pharmaceutical or personal care formulations contain both water-soluble and water-insoluble components. In some formulations, one or more active components may be water-soluble, while one or more inactive components may be either water-soluble (e.g., acacia gum) or water-insoluble (e.g., colorants).

[0004] Regulations on the use of ingredients may require companies to spend significant time and money refining their products. For example, recent regulations on the use of borax in personal care products required manufacturers to redesign their product formulations. Such product redesigns can be difficult if the product's physical appearance and feel are known or accepted by the public, or if the product has been approved by regulatory authorities with a particular formulation.

[0005] One of the challenges in compounding and recombining chemistry may be the ability to efficiently process materials. For example, some ingredients used in food, personal care, or pharmaceutical formulations have low fluidity during processing. In such cases, the production of the final product can be difficult and more expensive. [Overview of the project] [Problems that the invention aims to solve]

[0006] For this reason, there is a demand for improved formulations and methods for preparing them. [Means for solving the problem]

[0007] In one embodiment, the present invention provides a composition comprising: a: a stabilizer, demulcent, binder, emulsifier, or texturer; b: a water-insoluble inorganic substance; and c: a crosslinking agent.

[0008] Further embodiments, features, and advantages of the present invention will become apparent from the following detailed description and through the implementation of the present invention. Compounds of the present invention may be described as embodiments of any of the following enumerated sections. It will be understood that any embodiment described herein may be used in conjunction with any other embodiment described herein, to the extent that the embodiments are not inconsistent with each other.

[0009] Item 1 a: Colloidal material, b: Non-water-soluble inorganic substances, c: Crosslinking agent A composition containing the following:

[0010] Item 2 The composition according to Item 1, wherein the colloidal material is a stabilizer, demulcent, binder, emulsifier, or texturer.

[0011] Item 3 The colloidal material is gelatin, casein, albumin, agar, dextrin, sugar, gellan gum, xanthan gum, guar gum, acacia gum, corn fiber gum, peach gum, locust bean gum, gum rosin, tamarind gum, tragacanth gum, flaxseed gum, carrageenan gum ,Ta A composition according to claim 1 or 2, selected from the group consisting of ragum and sesbania gum.

[0012] Item 4 The composition according to any one of items 1 to 3, wherein the non-water-soluble inorganic substance is selected from the group consisting of dibasic calcium phosphate, tricalcium phosphate, dicalcium sulfate, iron oxide, yellow iron oxide, magnesium oxide, magnesium carbonate, barium sulfate, silicon, sulfur, and zinc oxide.

[0013] Item 5 The composition according to any one of items 1 to 4, wherein the crosslinking agent is selected from the group consisting of sodium aluminate, calcium aluminate, magnesium aluminate, barium aluminate, and strontium aluminate.

[0014] Item 6 A composition according to any one of items 1 to 5, having a basic flow energy of less than approximately 150 mJ.

[0015] Item 7 A composition according to any one of items 1 to 6, having a basic flow energy of less than approximately 125 mJ.

[0016] Item 8 A composition according to any one of items 1 to 7, having a basic flow energy of less than approximately 100 mJ.

[0017] Item 9. The composition according to any one of Items 1 to 8, having a basic flow energy of less than about 85% of the basic flow energy of the water-insoluble inorganic substance in the absence of the colloidal material and the crosslinking agent.

[0018] Item 10. The composition according to any one of Items 1 to 9, having a basic flow energy of less than about 75% of the basic flow energy of the water-insoluble inorganic substance in the absence of the colloidal material and the crosslinking agent.

[0019] Item 11. The composition according to any one of Items 1 to 10, having a conditioned bulk density of less than about 97% of the conditioned bulk density of the water-insoluble inorganic substance in the absence of the colloidal material and the crosslinking agent.

[0020] Item 12. The composition according to any one of Items 1 to 11, having a conditioned bulk density of less than about 95% of the conditioned bulk density of the water-insoluble inorganic substance in the absence of the colloidal material and the crosslinking agent.

[0021] Item 13. The composition according to any one of Items 1 to 12, having a volume moment average particle diameter of about 10 to about 50 microns.

[0022] Item 14. The composition according to any one of Items 1 to 13, having a volume moment average particle diameter of about 25 to about 50 microns.

[0023] Item 15. The composition according to any one of Items 1 to 14, wherein the water-insoluble inorganic substance is present in an amount of about 65% to about 85% by mass.

[0024] Item 16. The composition according to any one of Items 1 to 15, wherein the water-insoluble inorganic substance is present in an amount of about 70% to about 80% by mass. <​​​​​ Item 18 The composition according to any one of items 1 to 17, wherein the colloidal material is present in an amount of about 20% to about 25% by mass.

[0027] Item 19 The composition according to any one of items 1 to 18, wherein the crosslinking agent is present in an amount of about 0.3% by mass to about 1.5% by mass.

[0028] Item 20 The composition according to any one of items 1 to 18, wherein the crosslinking agent is present in an amount of about 2% by mass to about 4% by mass.

[0029] Item 21 The composition according to any one of items 1 to 20, further comprising about 1% to about 3% by mass of water.

[0030] Item 22 The composition according to Item 21, wherein the non-water-soluble inorganic substance is present in an amount of about 63% to about 85% by mass.

[0031] Item 23 The composition according to item 21 or 22, wherein the crosslinking agent is present in an amount of about 0.3% by mass to about 1.5% by mass.

[0032] Item 24 The composition according to any one of items 21 to 23, wherein the crosslinking agent is present in an amount of about 2% to about 4% by mass relative to the colloidal material.

[0033] Item 25 The composition according to any one of items 21 to 24, wherein the colloidal material is present in an amount of about 13% to about 34% by mass.

[0034] Item 26 a: Colloidal material, b: water-insoluble inorganic substance, c: Crosslinking agent, and d: water An aqueous composition containing the following:

[0035] Item 27 The aqueous composition according to Item 26, wherein the amount of water is about 40% by mass to about 70% by mass.

[0036] Item 28 The aqueous composition according to item 26 or 27, wherein the colloidal material is a stabilizer, lubricant, binder, emulsifier, or quality improver.

[0037] Item 29 The colloidal material is gelatin, casein, albumin, agar, dextrin, sugar, gellan gum, xanthan gum, guar gum, acacia gum, corn fiber gum, peach gum, locust bean gum, gum rosin, tamarind gum, tragacanth gum, flaxseed gum, carrageenan gum ,Ta An aqueous composition according to any one of claims 26 to 28, selected from the group consisting of lagum and sesbania gum.

[0038] Item 30 The aqueous composition according to any one of items 26 to 29, wherein the non-water-soluble inorganic substance is selected from the group consisting of dibasic calcium phosphate, tricalcium phosphate, dicalcium sulfate, iron oxide, yellow iron oxide, magnesium oxide, magnesium carbonate, barium sulfate, silicon, sulfur, and zinc oxide.

[0039] Item 31 The aqueous composition according to any one of items 26 to 30, wherein the crosslinking agent is selected from the group consisting of sodium aluminate, calcium aluminate, magnesium aluminate, barium aluminate, and strontium aluminate.

[0040] Item 32 The aqueous composition according to any one of items 26 to 31, wherein the non-water-soluble inorganic substance is present in an amount of about 19% to about 51% by mass.

[0041] Item 33 The aqueous composition according to any one of items 26 to 32, wherein the non-water-soluble inorganic substance is present in an amount of about 19% to about 40% by mass.

[0042] Item 34 The aqueous composition according to any one of items 26 to 33, wherein the colloidal material is present in an amount of about 4% to about 21% by mass.

[0043] Item 35 The aqueous composition according to any one of items 26 to 34, wherein the crosslinking agent is present in an amount of about 0.1% by mass to about 1% by mass.

[0044] Item 36 The aqueous composition according to any one of items 26 to 35, wherein the crosslinking agent is present in an amount of about 2.0% by mass to about 4.0% by mass relative to the colloidal material.

[0045] A personal care composition comprising a composition described in any one of paragraphs 1 to 25 or an aqueous composition described in any one of paragraphs 26 to 36, and a base composition.

[0046] Item 38 The personal care composition according to Item 37, wherein the base composition is a lotion, cream, face mask, conditioner, or serum.

[0047] Item 39 The personal care composition according to item 37 or 38, wherein the base composition is in the form of an emulsion, a surfactant system, or an aqueous gel.

[0048] Item 40 A personal care composition according to item 37 or 38, comprising a base composition selected from the group consisting of lotions, creams, face masks, conditioners, and serums, wherein the base composition is in the form of an emulsion.

[0049] Item 41 A personal care composition according to any one of items 37 to 39, comprising a base composition selected from the group consisting of body wash, facial cleanser, or shampoo, wherein the base composition is in the form of a surfactant.

[0050] Item 42 A personal care composition according to any one of items 37 to 39, comprising a base composition which is a serum, wherein the base composition is an aqueous gel. [Brief explanation of the drawing]

[0051] [Figure 1] Figure 1 is a chart showing the viscosity effect of several tested crosslinking agents on an acacia gum solution. [Figure 2]Figure 2 is a chart showing the viscosity effects of various concentrations of sodium aluminate and borax on a 25% acacia gum solution. [Figure 3A] Figure 3A shows 4% iron oxide colloid (left) compared to a non-colloidal 4% iron oxide composition. [Figure 3B] Figure 3B shows a microscopic image of 4% iron oxide colloid. [Figure 3C] Figure 3C shows a microscopic image of a non-colloidal 4% iron oxide composition. [Figure 3D] Figure 3D shows the particle size distribution of iron oxide colloid. [Figure 3E] Figure 3E shows the particle size distribution of iron oxide particles. [Figure 4A] Figure 4A shows a 5.33% sulfur colloid (left) compared to a non-colloidal 4% sulfur composition. [Figure 4B] Figure 4B shows a microscopic image of 5.33% sulfur colloid. [Figure 4C] Figure 4C shows a non-colloidal 4% sulfur composition. [Modes for carrying out the invention]

[0052] Before further describing the present invention, it will be understood that this disclosure is not limited to the specific embodiments described and is naturally subject to change. Since the scope of the present invention is limited only by the appended claims, it should also be understood that the terminology used herein is intended to describe only specific embodiments and is not intended to limit them.

[0053] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those widely understood by those skilled in the art in the field to which the present invention pertains. All patents, applications, published applications and other publications referenced herein are incorporated in their entirety by reference. If any definition in this section conflicts with or contradicts any definition in a patent, application or other publication incorporated by reference herein, the definition in this section shall prevail over the definition incorporated by reference herein.

[0054] Where used herein or in the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the context explicitly indicates otherwise. Furthermore, it should be noted that claims may be constructed to exclude any optional elements. This statement is therefore intended to serve as an antecedent basis for the use of exclusive terms such as “solely” and “only,” or for the use of “negative” limitations, in connection with the detailing of elements of the claims.

[0055] As used herein, the terms “including,” “containing,” and “comprising” are used in their open, non-restrictive sense.

[0056] To provide a more concise explanation, some of the quantitative expressions used herein are not modified with the term “about”. Whether the term “about” is explicitly used or not, all quantities given herein mean that they refer to the actual given value, and also to approximations of this given value that can be reasonably inferred on the basis of those skilled in the art, and it will be understood that this includes equivalents and approximations of this given value under experimental and / or measurement conditions. Where a yield is given as a percentage, that yield refers to the amount of substance of the yield given for the maximum amount of the same substance that can be obtained under a particular stoichiometric condition. Concentrations expressed as percentages refer to mass ratios unless otherwise indicated.

[0057] For clarity, it is understood that certain features of the Invention described in separate contexts may be provided in combination in a single embodiment. Conversely, for brevity, various features of the Invention described in the context of a single embodiment may also be provided separately or in any preferred subcombination. All combinations of embodiments relating to the chemicals employed in the Invention are disclosed herein, as are each combination and all combinations individually and expressly disclosed. Furthermore, all subcombinations of chemicals described in embodiments illustrating such variables are also specifically employed in the Invention and disclosed herein, as are each subcombination and all subcombinations individually and expressly disclosed.

[0058] In some embodiments, the compositions described herein include a: a colloidal material, b: a water-insoluble inorganic substance, and c: a crosslinking agent.

[0059] In some embodiments, the compositions described herein include a: a stabilizer, lubricant, binder, emulsifier or quality improver, b: a water-insoluble inorganic substance, and c: a crosslinking agent.

[0060] In some embodiments, the compositions of the present invention may be colloids. In some embodiments, the colloids described herein include a: a colloidal material, b: a water-insoluble inorganic substance, and c: a crosslinking agent. In some embodiments, the colloids described herein include a: a stabilizer, lubricant, binder, emulsifier, or quality improver, b: a water-insoluble inorganic substance, and c: a crosslinking agent. In some embodiments, the colloids described herein include a: a colloidal material which may be a stabilizer, lubricant, binder, emulsifier, quality improver, or a combination thereof, b: a water-insoluble inorganic substance, and c: a crosslinking agent.

[0061] It should be understood that the colloidal materials used in the compositions described herein are not particularly limited and may be colloidal materials known in the food, personal care, or pharmaceutical industries. It should also be understood that the stabilizers, lubricants, binders, emulsifiers, or quality improvers used in the compositions described herein are not particularly limited and may be any stabilizers, lubricants, binders, emulsifiers, or quality improvers known in the food, personal care, or pharmaceutical industries. In some embodiments, the stabilizers, lubricants, binders, emulsifiers, or quality improvers may be colloidal materials. As used herein, “colloidal material” refers to a material that functions to suspend particulate matter in a solution. It should be understood that colloidal materials are polysaccharides composed of sugar molecules containing carboxyl and hydroxyl groups. These colloidal materials are 1 × 10⁻⁶ 5 Larger than Da, especially 2 × 10 5 ~5×10 6 It will have a molecular weight of Da. Exemplary colloidal materials include, but are not limited to, bio gums, edible gums, natural gums, plant gums, starch gums, and polysaccharide gums. Examples of colloidal materials include, but are not limited to, gelatin, casein, albumin, agar, dextrin, sugars, gellan gum, xanthan gum, guar gum, acacia gum, corn fiber gum, peach gum, locust bean gum, gum rosin, tamarind gum, tragacanth gum, flaxseed gum, and carrageenan gum. ,TaThis includes lagum and sesbania gum. In some embodiments, the stabilizer, lubricant, binder, emulsifier, or quality improver may be a colloidal material which is acacia gum.

[0062] In some embodiments, the colloidal material is in an amount ranging from about 13% to about 35% by mass relative to the solids basis of the composition described herein. In some embodiments, the colloidal material is in an amount ranging from about 15% to about 30% by mass relative to the solids basis of the composition described herein. In some embodiments, the colloidal material is in an amount ranging from about 20% to about 25% by mass relative to the solids basis of the composition described herein. In some embodiments, the colloidal material is in an amount within any range of about 13% to about 35% by mass relative to the solids basis of the composition described herein.

[0063] In some embodiments, the amount of stabilizers, lubricants, binders, emulsifiers, or quality improvers is in the range of about 13% to about 35% by mass relative to the solids basis of the composition described herein. In some embodiments, the amount of stabilizers, lubricants, binders, emulsifiers, or quality improvers is in the range of about 15% to about 30% by mass relative to the solids basis of the composition described herein. In some embodiments, the amount of stabilizers, lubricants, binders, emulsifiers, or quality improvers is in the range of about 20% to about 25% by mass relative to the solids basis of the composition described herein. In some embodiments, the amount of stabilizers, lubricants, binders, emulsifiers, or quality improvers is in any range within the range of about 13% to about 35% by mass relative to the solids basis of the composition described herein.

[0064] It should be understood that the water-insoluble inorganic substances used in the compositions described herein are not particularly limited and may be any water-insoluble inorganic substances widely used in the food, personal care, or pharmaceutical industries. Examples of water-insoluble inorganic substances suitable for use in the embodiments described herein include, but are not limited to, calcium inorganic substances such as dibasic calcium phosphate (excipient used as a binder or filler), tricalcium phosphate (excipient used as a binder or filler), and dicalcium sulfate; iron inorganic substances such as fluoride, iodine, iron oxide (excipient or colorant), and yellow iron oxide (excipient or colorant); magnesium inorganic substances such as magnesium oxide (diluent) and magnesium carbonate (diluent); manganese inorganic substances; molybdenum inorganic substances; zinc inorganic substances such as phosphorus, silicon, sulfur, and zinc oxide (excipient used as a coloring additive); and barium sulfate (excipient). In some embodiments, the water-insoluble inorganic substance is present in an amount of about 65% to about 85% by mass relative to the solid content of the compositions described herein. In some embodiments, the water-insoluble inorganic substance is in an amount of about 70% to about 80% by mass relative to the solid content of the composition described herein. In some embodiments, the water-insoluble inorganic substance is in an amount of about 75% to about 80% by mass relative to the solid content of the composition described herein. In some embodiments, the water-insoluble inorganic substance is in an amount within any range of about 65% to about 85% by mass relative to the solid content of the composition described herein.

[0065] Non-water-soluble inorganic materials may also be in powder form. These non-water-soluble inorganic powders are available in a variety of particle sizes and particle size distributions. The particle sizes used herein may refer to the median particle size by volume or the mean volume moment D[4,3], as specified. An exemplary reference for the definition of particle size and its measurement method is the Malvern Instruments white paper, "A basic guide to particle characterization." Particle sizes are reported as measured by a Malvern Instruments particle analyzer or similar instrument. The compositions described herein are applicable to non-water-soluble inorganic materials with a median particle size by volume in the range of 5 to 100 microns in diameter. Some materials, such as magnesium oxide, are readily available with a narrow particle size distribution having a median particle size by volume of 10 or 50 microns. Others, such as sulfur, have a median particle size by volume of 25 to 45 microns and typically have a broader particle size distribution in the range of 2 to 110 microns.

[0066] It should be understood that the crosslinking agents used in the compositions described herein are not particularly limited, but can be any crosslinking agent that functions as an agglomerating or crosslinking agent by linking the hydroxyl and carboxyl groups of stabilizers, lubricants, binders, emulsifiers, or quality improvers such as colloidal materials. Exemplary crosslinking agents include, but are not limited to, borates, chromates, titanates, zirconates, and aluminates. In some embodiments, the crosslinking agent may be a metallic aluminate based on alkali metals or alkaline earth metals. Examples of crosslinking agents include, but are not limited to, sodium aluminate, calcium aluminate, magnesium aluminate, barium aluminate, and strontium aluminate. In some embodiments, the crosslinking agent is calcium aluminate. In some embodiments, the crosslinking agent is magnesium aluminate. In some embodiments, the crosslinking agent is barium aluminate. In some embodiments, the crosslinking agent is strontium aluminate. In some embodiments, the crosslinking agent is sodium aluminate. In some embodiments, the crosslinking agent is in an amount of about 0.3% to about 1.5% by mass relative to the solid content of the compositions described herein. In some embodiments, the crosslinking agent is present in an amount of about 0.5% to about 1% by mass relative to the solid content of the composition described herein. In some embodiments, the crosslinking agent is present in an amount of about 0.7% to about 1% by mass relative to the solid content of the composition described herein. In some embodiments, the crosslinking agent is present in an amount within any range of about 0.3% to about 1.5% by mass relative to the solid content of the composition described herein.

[0067] In some embodiments, the crosslinking agent is present in an amount of about 2.0% to about 4.0% by mass relative to the stabilizer, lubricant, binder, emulsifier, or quality improver. In some embodiments, the crosslinking agent is present in an amount of about 2.5% to about 3.5% by mass relative to the stabilizer, lubricant, binder, emulsifier, or quality improver. In some embodiments, the crosslinking agent is present in an amount of about 2.0% to about 3.0% by mass relative to the stabilizer, lubricant, binder, emulsifier, or quality improver. In some embodiments, the crosslinking agent is present in any amount within the range of about 2.0% to about 4.0% by mass relative to the stabilizer, lubricant, binder, emulsifier, or quality improver.

[0068] In some embodiments, the crosslinking agent is present in an amount of about 2.0% to about 4.0% by mass relative to the colloidal material. In some embodiments, the crosslinking agent is present in an amount of about 2.5% to about 3.5% by mass relative to the colloidal material. In some embodiments, the crosslinking agent is present in an amount of about 2.0% to about 3.0% by mass relative to the colloidal material. In some embodiments, the crosslinking agent is present in an amount within any range of about 2.0% to about 4.0% by mass relative to the colloidal material.

[0069] In some embodiments, the compositions described herein contain a certain amount of water. In some embodiments, the amount of water is up to about 3% by mass of the solid composition. In some embodiments, the amount of water is about 1% to about 3% by mass of the solid composition. It should be understood that the amounts of various components in the compositions described herein may be mass percentages measured with respect to the solids in the composition or absolute mass percentages of the various components in the composition. In some embodiments, if the composition, such as a spray-dried composition, is anhydrous, it should be understood that the solids basis of the composition may be approximately equivalent to the absolute. In some embodiments, if the composition, such as a spray-dried composition, contains water in an amount up to about 3% by mass of the composition, the values ​​of the amounts of various components in the compositions described herein may be mass percentages measured with respect to the solids in the composition, taking the amount of water into account. In some embodiments, if the composition, such as a spray-dried composition, contains water in an amount up to about 3% by mass of the composition, the values ​​of the amounts of various components in the compositions described herein may be mass percentages measured with respect to the absolute mass basis of the composition, including the amount of water in the composition.

[0070] In some embodiments, the compositions described herein have a basic flow energy. Exemplarily, basic flow energy is a measure of the composition's resistance to flow. For example, a composition with a higher basic flow energy may resist flow more in an auger system than a composition with a lower basic flow energy. Thus, improvement in basic flow energy can provide improved powder metering and processing. In some embodiments, the compositions described herein have a basic flow energy of less than about 150 mJ, less than about 125 mJ, or less than 100 mJ, as measured by a Freeman Technology FT4 powder rheometer. In some embodiments, the basic flow energy of a composition containing colloidal materials, crosslinkers, and water-insoluble inorganics is lower than the basic flow energy of a composition containing water-insoluble inorganics but without colloidal materials and crosslinkers. In some embodiments, the compositions, in the absence of colloidal materials and crosslinkers, have a basic flow energy of less than about 85% or less than 70% of the basic flow energy of water-insoluble inorganics.

[0071] In some embodiments, the compositions described herein have a conditioned bulk density. Measured under low stress and in a uniformly packed state, the conditioned bulk density represents the normal condition of the powder, unaffected by local stress or excess air. A decrease in conditioned bulk density can be an indicator of particle deaggregation, resulting in a more uniform particle size distribution compared to the bimodal distribution typically observed in powder samples with a high tendency to aggregate. Thus, an improvement in conditioned bulk density can provide improved dispersion properties. In some embodiments, the compositions described herein have a conditioned bulk density of less than about 0.8 g / mL, less than about 0.75 g / mL, or less than 0.7 g / mL, as measured by a Freeman Technology FT4 powder rheometer. In some embodiments, the conditioned bulk density of a composition containing colloidal materials, crosslinkers, and water-insoluble inorganic substances is lower than that of a composition containing water-insoluble inorganic substances but without colloidal materials and crosslinkers. In some embodiments, the composition has a conditioned bulk density of less than 97% or less than 95% of the conditioned bulk density of a non-water-soluble inorganic material in the absence of colloidal material and crosslinking agent.

[0072] In some embodiments, the compositions of the present invention, such as the colloidal compositions described herein, can be prepared as aqueous slurries. In some embodiments, the aqueous composition contains about 40% by mass to about 70% by mass of water. In some embodiments, the aqueous composition contains about 40% by mass to about 60% by mass of water. In some embodiments, the aqueous composition contains about 50% by mass of water. In some embodiments, the aqueous composition contains about 70% by mass of water. It should be understood that the amounts of various components in the compositions described herein may be mass percentages measured with respect to the solids in the composition or absolute mass percentages of the various components in the compositions described herein.

[0073] It should be understood that the compositions of the present invention, such as the colloidal compositions described herein, may be useful in a variety of applications requiring crosslinked compositions of non-water-soluble inorganic materials. In some embodiments, the compositions of the present invention, such as the colloidal compositions described herein, may be used in personal care products (also known as personal care compositions), which are known in the art as skincare products, antiperspirants, deodorants, cosmetics, haircare products, etc. In some embodiments, the compositions of the present invention, such as the colloidal compositions described herein, may be in an amount of about 0.1% to about 20% by mass of the personal care composition described herein. It should be understood that the range of amounts of the compositions of the present invention, such as the colloidal compositions described herein, used in personal care compositions includes all possible ranges and values ​​from 0.1% to 20% by mass, such as 6% to 20% by mass, 0.1% to 15% by mass, 4% to 10% by mass, 0.5% to 10% by mass, 1% to 10% by mass, 2% to 14% by mass, 3% to 13% by mass, and 2% to 5% by mass. Personal care products may have primary uses such as moisturizers, conditioners, anti-aging compositions, skin lighteners, sunscreens, antiperspirants, shave preparations, aftershaves, foundations, lipsticks, hair styling products, shampoos, cleansers, etc. Personal care products may include base compositions such as lotions, liquid soaps, creams, face masks, conditioners, serums, body washes, facial cleansers, and shampoos. It should be understood that personal care products can be formulated in various forms such as solutions (water or oil-based), dispersions, emulsions, aqueous gels, and surfactant systems. In some embodiments, personal care products may be fluids or solids such as gels, sticks, fluid solids, and amorphous materials. In some embodiments, the emulsion composition includes an aqueous phase, one or more emulsifiers, one or more emollients, one or more humectants, one or more skincare surfactants (such as hyaluronic acid, niacinamide, allantoin, panthenol, peptides, etc.), one or more rheological modifiers (such as synthetic gums and natural gums), or one or more preservatives, and other cosmetic ingredients.In some embodiments, the surfactant system includes water, one or more anionic, amphoteric, nonionic, and cationic surfactants, one or more moisturizers, one or more humectants, one or more plant-derived ingredients, one or more rheological modifiers, one or more preservatives, and other cosmetic ingredients. In some embodiments, the aqueous gel includes water, one or more rheological modifiers, one or more moisturizers, one or more humectants (such as glycerin, glycol, hyaluronic acid, niacinamide, allantoin, panthenol, peptides, and other skincare surfactants), one or more preservatives, and other cosmetic ingredients. It should be understood that "other cosmetic ingredients" include those outlined in The Personal Care Product Council's International Cosmetic Ingredient Dictionary & Handbook, 16th Edition.

[0074] It should be further understood that the uses of the compositions described herein may include mixing the compositions of the present invention, such as the colloidal compositions described herein, with any form of base composition and carrier described herein to provide a final product. As used herein, “carrier” means any carrier known in the art of personal care products, such as water (e.g., aqueous carrier), water-miscible solvent, or oil.

[0075] Suitable carriers include aqueous and / or water-miscible solvents. Personal care products may contain about 1% to about 95% by mass of water and / or water-miscible solvent. The composition includes about 1% by mass, about 3% by mass, about 5% by mass, about 10% by mass, about 15% by mass, about 20% by mass, about 25% by mass, about 30% by mass, about 35% by mass, about 40% by mass, About 45% by mass, about 50% by mass, about 55% by mass, about 60% by mass, about 65% by mass, about 70% by mass, about 75% by mass, about 80% by mass or about 90% by mass, about 95% by mass , about 90% by mass, about 85% by mass, about 80% by mass, about 75% by mass, about 70% by mass, about 65% by mass, about 60% by mass, about 55% by mass, about 50% by mass, about 45% by mass, about It may include 40%, about 35%, about 30%, about 25%, about 20%, about 15%, about 10%, or about 5% water and / or water-miscible solvents by weight. Suitable water-miscible solvents include monohydric alcohols, dihydric alcohols, polyhydric alcohols, glycerol, glycols, polyalkylene glycols such as polyethylene glycol, and mixtures thereof. Particularly suitable solvents include lower aliphatic alcohols such as ethanol, propanol, butanol, and isopropanol, diols such as 1,2-propanediol, 1,3-propanediol, butanediol, pentanediol, hexanediol, heptanediol, and decanediol, glycerin, water, and mixtures thereof. In certain embodiments, the personal care composition includes water, diols, glycerin, and combinations thereof.

[0076] Suitable carriers also include oils. Personal care compositions may contain one or more oils in an amount of about 0.1% to about 95% by mass. The composition may contain about 0.1% by mass, about 0.5% by mass, about 1% by mass, about 2% by mass, about 5% by mass, about 10% by mass, about 15% by mass, about 20% by mass, about 25% by mass, about 30% by mass, about 35% by mass, about 40% by mass, about 45% by mass, about 50% by mass, about 55% by mass, about 60% by mass, about 65% by mass, about 70% by mass, about 75% by mass, about 80% by mass, about 85% by mass, or about The oil may contain one or more oils in amounts ranging from 90% by mass to about 95% by mass, about 85% by mass, about 80% by mass, about 75% by mass, about 70% by mass, about 65% by mass, about 60% by mass, about 55% by mass, about 50% by mass, about 45% by mass, about 40% by mass, about 35% by mass, about 30% by mass, about 25% by mass, about 20% by mass, about 15% by mass, about 10% by mass, about 5% by mass, or about 3% by mass. The oil may be used to solubilize, disperse, or support materials that are not suitable for water or water-soluble solvents. Suitable oils include silicones, hydrocarbons, esters, amides, ethers, and mixtures thereof. The oil may be fluid under ambient conditions. However, certain forms of personal care products (i.e., solid or semi-solid sticks) may require non-flowing oils. The oil may be volatile or non-volatile. "Non-volatile" means a material that exhibits a vapor pressure of approximately 0.2 mmHg or less at 1 atmosphere and 25°C, and / or a material that has a boiling point of at least approximately 300°C at 1 atmosphere. "Volatile" means that a material exhibits a vapor pressure of at least approximately 0.2 mmHg at 20°C. Volatile oils may be used to provide a lighter feel when a heavy, oily film is undesirable.

[0077] Suitable oils include volatile oils. In certain embodiments, volatile oils may have a viscosity in the range of about 0.5 to 5 centistokes at 25°C. Volatile oils may be used to promote faster drying of the skincare composition after it has been applied to the skin. Non-volatile oils are also suitable for use in compositions. Non-volatile oils are commonly used for their skin-softening and protective properties.

[0078] Other suitable oils include esters. Suitable esters typically contain at least 10 carbon atoms. These esters include esters having hydrocarbyl chains derived from fatty acids or alcohols (e.g., monoesters, polyhydric alcohol esters, and di and tricarboxylic acid esters). The hydrocarbyl groups of the esters herein may contain or be covalently bonded to other suitable functional groups such as amide groups and alkoxy groups (e.g., ethoxy or ether bonds). Exemplary esters, but not limited to, include isopropyl isostearate, hexyl lauryl latate, isohexyl lauryl latate, isohexyl palmitate, isopropyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, dihexyldecyl adipate, lauryl lactate, myristyl lactate, cetyl lactate, oleyl stearate, oleyl oleate, oleyl myristate, lauryl acetate, cetyl propionate, and benzoic acid (C) 12 ~C 15 This includes alkyl groups, diisopropyl adipate, dibutyl adipate, and oleyl adipate. Other suitable esters are further described in The Personal Care Product Council's International Cosmetic Ingredient Dictionary & Handbook, 16th Edition, under the functional category of “Esters.” Other esters suitable for use in personal care compositions include those known as polyhydric alcohol esters and glycerides.

[0079] In some embodiments, personal care products comprising the base compositions described herein include a variety of components known to those skilled in the art, such as humectants, thickeners, suspending agents, emulsifiers, emollients, structuring agents, or pH adjusters.

[0080] Emulsifiers may be particularly preferred when the base composition is in the form of an emulsion or when immiscible materials are combined. Personal care products may contain emulsifiers in amounts ranging from about 0.05% by mass, about 0.1% by mass, about 0.2% by mass, about 0.3% by mass, about 0.5% by mass, or about 1% by mass, to about 20% by mass, about 10% by mass, about 5% by mass, about 3% by mass, about 2% by mass, or about 1% by mass. Emulsifiers may be nonionic, anionic, or cationic. Non-limiting examples of emulsifiers are disclosed in U.S. Patent No. 3,755,560, U.S. Patent No. 4,421,769, and McCutcheon's, Emulsifiers and Detergents, 2010 Annual Ed, published by MC Publishing Co. Other suitable emulsifiers are further listed in The Personal Care Product Council's International Cosmetic Ingredient Dictionary & Handbook, 16th Edition, under the functional category of “Surfactants - Emulsifying Agents.”

[0081] Structuring agents can be used to increase viscosity, thicken, solidify, or provide a solid or crystalline structure to personal care products. Structuring agents are typically grouped based on their solubility, dispersibility, and compatibility. Examples of aqueous or water-based structuring agents include polymers, natural or synthetic gums, polysaccharides, and the like. In some embodiments, a composition contains one or more structuring agents in about 0.0001% by mass, about 0.001% by mass, about 0.01% by mass, about 0.05% by mass, about 0.1% by mass, about 0.5% by mass, about 1% by mass, about 2% by mass, about 3% by mass, about 5% by mass to about 25% by mass, about 20% by mass, about 10% by mass, about 7% by mass, about 5% by mass, about 4% by mass, or about 2% by mass of the composition.

[0082] Polysaccharides and gums can be suitable aqueous phase thickeners. Suitable classes of polymer structuring agents include, but are not limited to, carboxylic acid polymers, polyacrylamide polymers, sulfonated polymers, high molecular weight polyalkyl glycols or polyglycerins, copolymers thereof, hydrophobic modified derivatives thereof, and mixtures thereof.

[0083] In some embodiments, other ingredients provided to the personal care product include, but are not limited to, glycerin, xanthan gum, cetearyl alcohol / ceteareth-20 blend, glyceryl stearate / PEG-100 stearate blend, dicaprylic adipate, and dimethicone. In some embodiments, the base composition includes 10-15% by mass of glycerin or other humectants such as propylene glycol, 2-5% by mass of other thickeners / suspending agents such as xanthan gum or acrylate copolymer or synthetic polymer, 48-62% by mass of emulsifiers such as PEG-150 distearate, ceteareth-20, ceteareth-25, glyceryl hydroxystearate, stearic acid, hydroxystearic acid, cetyl alcohol, stearyl alcohol, emulsifying wax NF, polysorbate 20, cetearyl alcohol, glyceryl stearate, PEG-100 stearate and / or blends thereof, and 20-30% by mass of dicapryl adipate, dimethicone, and C benzoate. 12 ~C 15 It contains emollients such as alkyl, tri(caprylic / capric acid) glycerides, isopropyl myristate, or isopropyl palmitate. In some embodiments, the mass percentage values ​​provided above are "dry" or "non-aqueous" values.

[0084] In some embodiments, the base composition comprises 1.0 to 5.0% by weight of other humectants such as glycerin or propylene glycol, 0.1 to 0.75% by weight of other thickeners / suspending agents such as xanthan gum or acrylate copolymer or synthetic polymer, 3 to 10% by weight of PEG-150 distearate, cetearyl alcohol-20, cetearyl alcohol-25, glyceryl hydroxystearate, stearic acid, hydroxystearic acid, cetyl alcohol, stearyl alcohol, wax NF for emulsification, polysorbate 20, cetearyl alcohol, glyceryl stearate, stearic acid PEG-100 and / or blends thereof, etc. emulsifiers, 1.0 to 5.0% by weight of dicapryl adipate, dimethicone, benzoic acid C 12 ~C 15 alkyl, and skin softeners such as tri(caprylic / capric acid) glyceride, isopropyl myristate or isopropyl palmitate. In some embodiments, the personal care product may contain 60 to 80% by weight of water.

[0085] In some embodiments, the base composition comprises 1.5 to 2.25% by weight of other humectants such as glycerin or propylene glycol, 0.3 to 0.75% by weight of other thickeners / suspending agents such as xanthan gum or acrylate copolymer or synthetic polymer, 7.2 to 9.3% by weight of PEG-150 distearate, cetearyl alcohol-20, cetearyl alcohol-25, glyceryl hydroxystearate, stearic acid, hydroxystearic acid, cetyl alcohol, stearyl alcohol, wax NF for emulsification, polysorbate 20, cetearyl alcohol, glyceryl stearate, stearic acid PEG-100 and / or blends thereof, etc. emulsifiers, 3.0 to 3.5% by weight of dicapryl adipate, dimethicone, benzoic acid C 12 ~C 15 alkyl, and skin softeners such as tri(caprylic / capric acid) glyceride, isopropyl myristate or isopropyl palmitate. In some embodiments, the personal care product may contain 60 to 80% by weight of water.

[0086] The compositions and products described herein can be demonstrated by the following non-limiting examples. Those skilled in the art should understand that alternative compositions and products can be prepared by adapting the examples provided herein based on the descriptions provided for various embodiments. [Examples]

[0087] Example 1 The combinations of acacia gum and crosslinking agents were evaluated by dissolving 25 grams of gum in 75 grams of deionized water, mixing until the solution became clear, and then slowly adding the crosslinking agent under evaluation while heating to 76°C. Each solution was cooled to room temperature for 24 hours. The viscosity of the solutions was measured at 25°C using a Brookfield LV DV-II+ viscometer. The viscosity measurements showed significant differences between the prepared samples. A non-crosslinked solution was prepared as a control with a measured viscosity of 80 cP, while a comparative borax solution was prepared with a measured viscosity of over 100,000 cP. Various levels of each crosslinking agent, ranging from 2% to 10% relative to the mass of acacia gum in a 25% aqueous solution, were evaluated, resulting in similar increases in the viscosity of the gum solutions (Figure 1). Sodium aluminate was the only additive that produced a significant effect on viscosity.

[0088] [Table 1]

[0089] Example 2 Using the method described in Example 1, we compared the viscosity increases of various concentrations of borax and sodium aluminate added to a 25% acacia gum solution (Table 2 and Figure 2). It was found that sodium aluminate could achieve properties comparable to borax by adjusting the packing level in the mixture.

[0090] [Table 2]

[0091] Example 3 The components shown in Table 3 were mixed with deionized water to prepare an aqueous slurry with 30% by mass of solids. Using typical parameters for a water-based system, the slurry was spray-dried to achieve a moisture content of less than 3%. The resulting powder was analyzed for particle size distribution and moisture content using a Malvern Instruments particle analyzer. Conditioned bulk density (CBD) and basic flow energy (BFE) were determined using a Freeman Technology FT4 powder rheometer. BFE analysis confirmed improved powder flowability of the spray-dried product compared to untreated non-water-soluble inorganic material. Lower BFE values ​​indicate better limiting flow behavior. The results are shown in Table 3.

[0092] [Table 3]

[0093] Example 4 Experiments were conducted to confirm improved dispersibility and deaggregation in viscous suspensions. Suspensions were prepared under the same processing conditions using both the spray-dried powder product from Example 3 and each untreated non-water-soluble inorganic material (Table 4). Suspension G contained a larger amount of spray-dried powder and was equivalent to the inorganic material content of 75% of the total inorganic material content of the untreated non-water-soluble inorganic material. The obtained suspensions were spread into thin films using a drawdown bar, and the dispersibility and deaggregation of each colloid system were compared with their respective controls. If the dispersion was not clearly uniform and large aggregates were observed in the drawdown film, the test result was considered a failure. See Figures 3A-3C and 4A-4C for images of the drawdown films. See Figures 3D and 3E for a comparison of particle sizes between iron oxide colloid powder (Figure 3D) and iron oxide powder (Figure 3E).

[0094] [Table 4]

[0095] **The suspension base contains 13% glycerin, 3% xanthan gum, 21% cetearyl alcohol / ceteareth-20 blend, 35% glyceryl stearate / PEG-100 stearate blend, 14% dicaprylate adipate, and 14% dimethicone.

Claims

1. a: A colloidal material selected from polysaccharides composed of sugar molecules containing carboxyl groups and hydroxyl groups. b: Non-water-soluble inorganic substances selected from the group consisting of iron oxide, yellow iron oxide, magnesium oxide, silicon, sulfur, and zinc oxide, and c: Crosslinking agent selected from metal aluminates based on alkali metals or alkaline earth metals Includes, A colloidal composition in which the colloidal material is selected from the group consisting of agar, welan gum, xanthan gum, acacia gum, gum rosin, tragacanth gum, and sesbania gum.

2. The composition according to claim 1, wherein the colloidal material is a stabilizer, a demulcent, a binder, an emulsifier, or a texturer.

3. The composition according to claim 1 or 2, wherein the water-insoluble inorganic substance is selected from the group consisting of silicon, sulfur, and zinc oxide.

4. The composition according to any one of claims 1 to 3, wherein the water-insoluble inorganic substance is selected from the group consisting of silicon and sulfur.

5. The composition according to any one of claims 1 to 4, wherein the crosslinking agent is selected from the group consisting of sodium aluminate, calcium aluminate, magnesium aluminate, barium aluminate, and strontium aluminate.

6. The composition according to any one of claims 1 to 5, having a basic flow energy of less than 150 mJ.

7. The composition according to any one of claims 1 to 6, having a basic flow energy of less than 125 mJ.

8. The composition according to any one of claims 1 to 7, having a basic flow energy of less than 100 mJ.

9. The composition according to any one of claims 1 to 8, having a basic flow energy of less than 85% of the basic flow energy of the non-water-soluble inorganic substance in the absence of the colloidal material and the crosslinking agent.

10. The composition according to any one of claims 1 to 9, having a basic flow energy of less than 75% of the basic flow energy of the non-water-soluble inorganic substance in the absence of the colloidal material and the crosslinking agent.

11. The composition according to any one of claims 1 to 10, having a conditioned bulk density of less than 97% of the conditioned bulk density of the non-water-soluble inorganic material in the absence of the colloidal material and the crosslinking agent.

12. The composition according to any one of claims 1 to 11, having a conditioned bulk density of less than 95% of the conditioned bulk density of the non-water-soluble inorganic substance in the absence of the colloidal material and the crosslinking agent.

13. The composition according to any one of claims 1 to 12, having a volume moment average particle diameter of 10 to 50 microns.

14. The composition according to any one of claims 1 to 13, having a volume moment average particle diameter of 25 to 50 microns.

15. The composition according to any one of claims 1 to 14, wherein the amount of the non-water-soluble inorganic substance is 65% to 85% by mass.

16. The composition according to any one of claims 1 to 15, wherein the amount of the water-insoluble inorganic substance is 70% to 80% by mass.

17. The composition according to any one of claims 1 to 16, wherein the colloidal material is present in an amount of 13% to 35% by mass.

18. The composition according to any one of claims 1 to 17, wherein the colloidal material is present in an amount of 20% to 25% by mass.

19. The composition according to any one of claims 1 to 18, wherein the amount of the crosslinking agent is 0.3% by mass to 1.5% by mass.

20. The composition according to any one of claims 1 to 18, wherein the crosslinking agent is present in an amount of 2% to 4% by mass relative to the colloidal material.

21. The composition according to any one of claims 1 to 20, further comprising 1% to 3% by mass of water.

22. The composition according to claim 21, wherein the amount of the non-water-soluble inorganic substance is 63% to 85% by mass.

23. The composition according to claim 21 or 22, wherein the amount of the crosslinking agent is 0.3% by mass to 1.5% by mass.

24. The composition according to any one of claims 21 to 23, wherein the crosslinking agent is present in an amount of 2% to 4% by mass relative to the colloidal material.

25. The composition according to any one of claims 21 to 24, wherein the colloidal material is present in an amount of 13% to 34% by mass.

26. a: A colloidal composition according to any one of claims 1 to 20, and b: water An aqueous composition containing the following:

27. The aqueous composition according to claim 26, wherein the amount of water is 40% to 70% by mass.

28. The aqueous composition according to claim 26 or 27, wherein the amount of the non-water-soluble inorganic substance is 19% by mass to 51% by mass.

29. The aqueous composition according to any one of claims 26 to 28, wherein the amount of the non-water-soluble inorganic substance is 19% to 40% by mass.

30. The aqueous composition according to any one of claims 26 to 29, wherein the colloidal material is present in an amount of 4% to 21% by mass.

31. The aqueous composition according to any one of claims 26 to 30, wherein the amount of the crosslinking agent is 0.1% by mass to 1% by mass.

32. The aqueous composition according to any one of claims 26 to 31, wherein the amount of the crosslinking agent is 2.0% to 4.0% by mass relative to the colloidal material.

33. A personal care composition comprising the composition according to any one of claims 1 to 25 or the aqueous composition according to any one of claims 26 to 32, and a base composition.

34. The personal care composition according to claim 33, wherein the base composition is a lotion, cream, face mask, conditioner, or serum.

35. The personal care composition according to claim 33 or 34, wherein the base composition is in the form of an emulsion, a surfactant, or an aqueous gel.

36. The personal care composition according to claim 33 or 34, comprising a base composition selected from the group consisting of lotion, cream, face mask, conditioner, and serum, wherein the base composition is in the form of an emulsion.

37. A personal care composition according to any one of claims 33 to 35, comprising a base composition selected from the group consisting of body wash, facial cleanser, or shampoo, wherein the base composition is in the form of a surfactant.

38. A personal care composition according to any one of claims 33 to 35, comprising a base composition which is a serum, wherein the base composition is an aqueous gel.

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