Foaming topical skin preparation

Abstract

To provide a foamable skin external preparation which has good use feeling and is effective for improving skin conditions.SOLUTION: There is provided a foamable skin external preparation having at least a solid acid substance and a solid carbon dioxide generating substance which generates carbon dioxide by reacting with the acid substance, which further contains at least one selected from a cellulose derivative and a starch derivative as a polysaccharide or a derivative thereof and at least one selected from a hydrophilic natural polymer which is alginic acid or a salt thereof, carrageenan, guar gum, locust bean gum, xanthan gum or tamarind gum (provided that alginic acid or a salt thereof is excluded when sodium carboxymethyl cellulose is contained as a cellulose derivative), in which the skin external preparation is mixed with a water-containing substance when used.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an external preparation for skin.

Background Art

[0002] Conventionally, external preparations for skin containing synthetic or natural extracts having a blood circulation promoting action on the skin have been used.

[0003] Since these extracts have insufficient effects when formulated in small amounts and cause excessive irritation to the skin when formulated in large amounts, proposals have been made for external preparations for skin that contain carbon dioxide gas to enhance the blood circulation promoting action. Many of these generate carbon dioxide gas by the reaction of an acidic substance and a carbon dioxide gas generating substance. As dosage forms of these external preparations for skin, those in which the acidic substance and the carbon dioxide gas generating substance are separate agents and are mixed and foamed at the time of use are known from the viewpoint of maintaining the carbon dioxide generating ability of the external preparation for skin for a long period (Patent Documents 1 and 2). On the other hand, external preparations for skin containing an acidic substance and a carbon dioxide gas generating substance and mixed with a viscous composition containing water and a thickening agent at the time of use are also known (Patent Document 3).

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Patent Document 3

Summary of the Invention

Problems to be Solved by the Invention

[0005] Foaming external preparations for skin that contain an acidic substance and a carbon dioxide gas generating substance and are mixed with a hydrous substance at the time of use have advantages such as being easy to handle when made into a single dosage form. However, conventionally, this type of topical skin preparation has been insufficient in terms of achieving both ease of mixing and application when used with water-containing substances, and the effect of improving skin condition, such as skin moisture, elasticity, and brightness. [Means for solving the problem]

[0006] The present invention relates to a foaming topical skin preparation comprising at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, further, A polysaccharide or its derivative, comprising at least one selected from cellulose derivatives and starch derivatives, It contains at least one hydrophilic natural polymer selected from alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum (however, if it contains sodium carboxymethylcellulose as a cellulose derivative, alginic acid or its salts are excluded), The present invention provides an effervescent topical skin preparation that mixes with a water-containing substance when used as described above.

[0007] Furthermore, the present invention relates to a foaming topical skin preparation comprising at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and further, It contains two or more hydrophilic natural polymers selected from alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum as polysaccharides or derivatives thereof. The present invention provides an effervescent topical skin preparation that mixes with a water-containing substance when used as described above.

[0008] Furthermore, the present invention relates to a foaming topical skin preparation comprising at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and further, It contains two or more polysaccharides or their derivatives selected from cellulose derivatives and starch derivatives, The present invention provides an effervescent topical skin preparation that mixes with a water-containing substance when used as described above.

[0009] Furthermore, the present invention relates to a foaming topical skin preparation comprising at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and further, At least one polysaccharide or its derivative, It contains at least one inorganic hydrophilic thickening compound or an organic hydrophilic synthetic polymer that is a thickening agent. The present invention provides an effervescent topical skin preparation that mixes with a water-containing substance when used as described above. [Effects of the Invention]

[0010] According to the present invention, it is possible to provide a topical skin preparation that is pleasant to use and effective in improving the condition of the skin. [Brief explanation of the drawing]

[0011] [Figure 1] Figure 1 is a graph showing the rate of change in L* value (whiteness) in the examples and comparative examples. [Figure 2] Figure 2 is a graph showing the percentage change in stratum corneum moisture content in the examples and comparative examples. [Figure 3] Figure 3 is a graph showing the rate of change in elasticity in the examples and comparative examples. [Figure 4] Figure 4 is a graph showing the amount of foaming (volume increase rate of the mixture of the topical skin preparation and the water-containing substance) in the examples and comparative examples. [Figure 5] Figure 5 is a graph showing the amount of carbon dioxide generated in the examples and comparative examples. [Figure 6] Figure 6 is a graph showing the rate of change in moisture evaporation in the example. [Figure 7] Figure 7 is a graph showing the rate of change in stratum corneum moisture content in another embodiment. [Figure 8] Figure 8 is a graph showing the rate of change of the L* value in another embodiment. [Figure 9]Figure 9 is a graph showing the change rate of the horny moisture content in another embodiment. [Figure 10] Figure 10 is a graph showing the change rate of elasticity in another embodiment. [Figure 11] Figure 11 is a graph showing the change rate of the amount of water evaporation in another embodiment. MODE FOR CARRYING OUT THE INVENTION

[0012] The skin external preparation of the present invention contains at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide gas.

[0013] And the skin external preparation of the present invention is used by a user applying it to the skin after generating foaming due to carbon dioxide gas generation by mixing the skin external preparation and a hydrous substance at the time of use. Hereinafter, each constituent component contained in the skin external preparation and its production method will be described.

[0014] <Solid acidic substance> As the solid acidic substance used in the present invention, either an inorganic acid or an organic acid may be used, and one or more of these are used. Also, any dosage form may be used as long as it is solid, but powdery forms such as granular and powdery are preferable, and powdery is particularly preferable.

[0015] Examples of inorganic acids include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite, potassium pyrosulfite, sodium acid hexametaphosphate, potassium acid hexametaphosphate, sodium acid pyrophosphate, potassium acid pyrophosphate, sulfamic acid, and the like.

[0016] Examples of organic acids include straight-chain fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid; dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, and terephthalic acid; acidic amino acids such as glutamic acid and aspartic acid; and oxyacids such as glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartonic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, and gluconic acid.

[0017] In particular, citric acid, ascorbic acid, malic acid, and succinic acid are preferred from the viewpoint of safety and solubility in water.

[0018] The content of the solid acidic substance in the topical skin preparation of the present invention is preferably 1% by mass or more and 20% by mass or less, and more preferably 2% by mass or more and 18% by mass or less.

[0019] <Solid carbon dioxide generating substance> The solid carbon dioxide generating substance that reacts with the acidic substance used in the present invention to produce carbon dioxide can be a variety of substances without particular limitations. Furthermore, any dosage form is acceptable as long as it is solid, but granular or powdery forms are preferred, and powdery forms are particularly preferred.

[0020] Examples of carbon dioxide generating substances include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, and sodium sesquicarbonate, and bicarbonates such as ammonium bicarbonate, potassium bicarbonate, sodium bicarbonate, lithium bicarbonate, cesium bicarbonate, magnesium bicarbonate, and calcium bicarbonate. One or more of these can be used. Among these, bicarbonates are preferred, and sodium bicarbonate is more preferred because it can achieve a moderate foaming force.

[0021] The content of the carbon dioxide generating substance in the topical skin preparation of the present invention is preferably 1% by mass or more and 30% by mass or less, and more preferably 2% by mass or more and 25% by mass or less.

[0022] <Polysaccharides or their derivatives> Examples of polysaccharides or their derivatives used in the present invention include various types that can be used in the fields of cosmetics and pharmaceuticals. Specific examples of polysaccharides include hydrophilic natural polymers such as xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, galactan, gum arabic, tragacanth gum, tamarind gum, agar, agarose, mannan, hyaluronic acid and its salts, chondroitin sulfate and its salts, curdlan, pectin, alginic acid and its salts, starch, dextrin, cellulose, etc.; starch derivatives such as carboxymethyl starch and its salts, acrylic acid grafted starch and its salts, hydroxypropyl cellulose and its derivatives, hydroxyethyl cellulose and its derivatives, hydroxypropyl methylcellulose, etc. Examples of hydrophilic synthetic polymers include hydroxypropyl methylcellulose derivatives such as hydroxypropyl methylcellulose having hydrocarbon groups such as hydroxypropyl methylcellulose phthalate and stearyl groups, sulfonated cellulose derivatives, carboxymethylcellulose and its derivatives and their salts, carboxymethyl ethylcellulose and its salts, cellulose acetate phthalate, cationized cellulose such as O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride (also known as "polyquaternium-10"), ethylcellulose, chlorocarmellose and its salts, and other cellulose derivatives. These can be used individually or in combination of two or more. As illustrated above, dextrin is not included in the starch derivatives in this specification. Examples of the salts include sodium salts, potassium salts, calcium salts, etc. Examples of derivatives of hydroxypropylcellulose include hydroxypropylcellulose acetate and hydroxypropylcellulose propionate; examples of derivatives of hydroxyethylcellulose include hydroxyethylcellulose acetate, hydroxyethylcellulose propionate and polyquaternium-67; and examples of derivatives of carboxymethylcellulose include carboxymethylcellulose acetate, carboxymethylcellulose propionate and methylamide cellulose gum.

[0023] Furthermore, it is preferable to use polysaccharides or derivatives thereof that have high solubility and / or dispersibility in water when used in the present invention, because this allows the topical skin preparation of the present invention to dissolve and / or disperse uniformly without forming clumps when mixed with a water-containing substance, thereby mitigating the rough feeling on the skin caused by undissolved components. Here, the quality of solubility and dispersibility in water can be determined by whether the topical skin preparation dissolves or disperses uniformly in a short time when water at room temperature is added and stirred, and whether clumps are formed during dissolution.

[0024] From the viewpoint of solubility and dispersibility in water as described above, preferred polysaccharides or their derivatives include, for example, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, galactan, gum arabic, tragacanth gum, tamarind gum, agar, agarose, mannan, hyaluronic acid and its salts, curdlan, alginic acid and its salts, starch and its derivatives, dextrin, cellulose and cellulose derivatives, and the like.

[0025] While only one of the polysaccharides or derivatives used in this invention may be used, it is preferable to use two or more in combination. This is for the following reasons. Many polysaccharides or their derivatives dissolve or disperse in water to exert a thickening effect. Adding polysaccharides or their derivatives to topical skin preparations also has the advantage of improving the stability of the preparation before use and during storage, and preventing the reaction between acids and carbon dioxide-producing substances, thereby preventing the generation of carbon dioxide. Among polysaccharides or their derivatives, some contribute more to the thickening effect than to storage stability (hereinafter referred to as Type A polysaccharides or their derivatives), while others contribute more to storage stability than to the thickening effect (hereinafter referred to as Type B polysaccharides or their derivatives). Therefore, by combining both types of polysaccharides or their derivatives, it is possible to improve both the thickening effect and storage stability. Examples of Type A polysaccharides or their derivatives include xanthan gum, carrageenan, hyaluronic acid, and cellulose and its salts or derivatives, while preferred Type B polysaccharides or their derivatives include starch or its derivatives and dextrin. By using type B polysaccharides or their derivatives, the generation of carbon dioxide during the storage of topical skin preparations can be suppressed. In particular, using starch or its derivatives is preferable because it effectively suppresses the generation of carbon dioxide and further improves long-term storage stability. When using starch or its derivatives in the present invention, the preferred amount to use is 3% by mass or more, particularly 5% by mass or more, and especially 10% by mass or more in the topical skin preparation. In the present invention, it is preferable to have a large variety of polysaccharides or their derivatives, for example, a combination of three or more types.

[0026] Furthermore, as is clear from the examples described later, for example, a comparison of Examples 1 and 2, the inventors found that when two or more polysaccharides or their derivatives are used in combination, compared to when only one is used, the carbon dioxide retention capacity of the topical skin preparation (mixture) when mixed with a water-containing substance is higher, the mixture applied to the skin is less likely to drip, it is easier to obtain skin condition improvement effects such as improved redness and elasticity, and the user experience, including ease of application and removal, is improved. Furthermore, as is clear from Examples 6 to 10, the inventors found that these effects are even greater in the presence of water-soluble proteins and / or natural surfactants, particularly extracts containing saponins.

[0027] In the present invention, the content of polysaccharides or their derivatives in the topical skin preparation is preferably 8% by mass or more and 50% by mass or less, and more preferably 11% by mass or more and 45% by mass or less. A polysaccharide or its derivative content of 8% by mass or more and 50% by mass or less is preferable from the viewpoint of handling during use, in particular, because it mixes easily when mixed with water-containing substances and does not drip easily during use. A content of less than 8% by mass is undesirable because it drips easily during use, and a content of more than 50% by mass is undesirable because it is difficult to mix and thickens immediately after mixing with water-containing substances, making it difficult to apply to the application site.

[0028] Furthermore, when using a combination of a polysaccharide or its derivative of type A and a polysaccharide or its derivative of type B, the mass ratio of the two is preferably 10 to 1000 parts by mass of polysaccharide or its derivative of type B, and more preferably 20 to 800 parts by mass, per 100 parts by mass of polysaccharide or its derivative of type A.

[0029] The inventors have further found that when the topical skin preparation of the present invention contains two or more polysaccharides or their derivatives in any of the following embodiments (1) to (3), the effects of the present invention, namely "pleasant to use and improvement of skin condition," are particularly pronounced. (1) When the product contains at least one selected from cellulose derivatives and starch derivatives, and at least one selected from hydrophilic natural polymers, which are alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum (however, if the cellulose derivative contains sodium carboxymethylcellulose, then alginic acid and its salts are excluded). (2) When the polysaccharide or derivative thereof contains two or more selected hydrophilic natural polymers, such as alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum. (3) When the product contains two or more polysaccharides or derivatives thereof, selected from cellulose derivatives and starch derivatives.

[0030] Hereinafter, hydrophilic natural polymers that are alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum may simply be referred to as "specific hydrophilic natural polymers."

[0031] First, let's explain case (1). In the case of (1), the following embodiments of (a) or (b) are preferred as embodiments of which contain two or more polysaccharides or their derivatives, from the viewpoint of more reliably enhancing the effects of the present invention, which are "good to use and improve the condition of the skin". (a) The cellulose derivative contains at least one selected from hydroxyethylcellulose and its derivatives, carboxymethylcellulose and its derivatives and their salts, hydroxypropylmethylcellulose and its derivatives, sulfonated cellulose derivatives, carboxymethylethylcellulose and its salts, cellulose phthalate acetate, cationized cellulose, ethylcellulose, and croscarmellose and its salts, or / and It contains starch derivatives.

[0032] (b) Contains at least one selected from hydroxypropylcellulose and its derivatives as a cellulose derivative, and at least one selected from alginic acid and its salts, carrageenan, guar gum, xanthan gum, and tamarind gum as a hydrophilic natural polymer.

[0033] In the case of (1), particularly preferred embodiments containing two or more polysaccharides or their derivatives include any of the following (a) to (c). (a) The cellulose derivative contains at least one selected from hydroxypropyl methylcellulose and its derivatives and cationized cellulose, or / or the starch derivative contains at least one selected from carboxymethyl starch and its salts and acrylic acid grafted starch and its salts. (i) Contains at least one selected from hydroxyethylcellulose and its derivatives as a cellulose derivative, and at least one selected from alginic acid and its salts, carrageenan, guar gum, locust bean gum, and tamarind gum as a hydrophilic natural polymer. (c) Contains at least one selected from carboxymethylcellulose and its derivatives and their salts as a cellulose derivative, and at least one selected from carrageenan, guar gum, locust bean gum and tamarind gum as a hydrophilic natural polymer.

[0034] In the case of (1), a particularly preferred embodiment containing two or more polysaccharides or derivatives thereof is the case in which any of the following combinations of polysaccharides or derivatives are included. A combination of at least one selected from hydroxypropyl methylcellulose and its derivatives, and at least one selected from alginic acid and its salts, and xanthan gum; A combination of cationized cellulose and tamarind gum; A combination of starch derivatives and tamarind gum; A combination of at least one selected from hydroxyethylcellulose and its derivatives, and at least one selected from alginic acid and its salts, and carrageenan; A combination of at least one selected from carboxymethylcellulose and its derivatives and their salts, and at least one selected from carrageenan and guar gum.

[0035] As in the case of (1) above, when a cellulose derivative or starch derivative is combined with a specific hydrophilic natural polymer, it is preferable from the viewpoint of more reliably obtaining the effects of the present invention that the amount of the specific hydrophilic natural polymer per 100 parts by mass of the cellulose derivative or starch derivative is 1 part by mass or more and 10,000 parts by mass or less. From this viewpoint, it is preferable that the amount of the specific hydrophilic natural polymer per 100 parts by mass of the cellulose derivative or starch derivative is 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1,000 parts by mass or less. The amount of cellulose derivative or starch derivative referred to here is the total amount if the topical skin preparation contains a cellulose derivative and a starch derivative. The amounts of cellulose derivative, starch derivative and hydrophilic natural polymer referred to here may be the amounts of the specific type of cellulose derivative, starch derivative and hydrophilic natural polymer if the topical skin preparation of the present invention contains a specific type of cellulose derivative, starch derivative and hydrophilic natural polymer. Similarly, the amounts of cellulose derivatives, starch derivatives, and hydrophilic natural polymers referred to below can also be the amounts of those specific types of cellulose derivatives, starch derivatives, and hydrophilic natural polymers if the topical skin preparation of the present invention contains specific types of cellulose derivatives, starch derivatives, and hydrophilic natural polymers.

[0036] In both case (1) and cases (2) to (4) below, the proportion of the total amount of cellulose derivatives, starch derivatives, and specific hydrophilic natural polymers in the topical skin preparation is preferably 5% by mass or more in order to enhance the effects of the present invention, and 50% by mass or less is preferable from the viewpoint of ensuring the amount of acidic substances and carbon dioxide generating substances, preventing a decrease in the foaming properties of the topical skin preparation of the present invention, and ensuring functionality such as the feel of use and the effect of improving the condition of the skin. From this viewpoint, the proportion of the total amount of cellulose derivatives, starch derivatives, and specific hydrophilic natural polymers in the topical skin preparation is more preferably 10% by mass or more and 45% by mass or less, and particularly preferably 12% by mass or more and 45% by mass or less.

[0037] Next, we will explain case (2). In case (2) above, the topical skin preparation contains two or more hydrophilic natural polymers selected as polysaccharides or derivatives thereof, which are alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum. In this case, from the viewpoint of making the effects of the present invention, which are "pleasant to use and improve the condition of the skin," even more pronounced, it is particularly preferable that the combination of these two or more specific hydrophilic natural polymers be one of the following (A) to (C).

[0038] (A) A combination of alginic acid or a salt thereof and at least one selected from carrageenan, guar gum, locust bean gum, and tamarind gum. (B) A combination of carrageenan and at least one selected from alginic acid and its salts, guar gum, xanthan gum, and tamarind gum. (C) A combination of two or more gums selected from guar gum, locust bean gum, xanthan gum, and tamarind gum.

[0039] When two or more specific hydrophilic natural polymers are included, particularly preferred combinations include any of the following (A)' to (C)'. (A)' A combination of alginic acid or its salts and at least one selected from carrageenan and tamarind gum; (B)' A combination of carrageenan and at least one selected from xanthan gum and tamarind gum; (C)' A combination of tamarind gum and at least one selected from guar gum and xanthan gum.

[0040] (2) When the product contains two or more hydrophilic natural polymers selected from alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum as polysaccharides or derivatives thereof, the content of any one of the other polymers per 100 parts by mass of one of the other polymers is preferably 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1,000 parts by mass or less.

[0041] In the case of (A), the content of at least one selected from carrageenan, guar gum, locust bean gum, and tamarind gum per 100 parts by mass of alginic acid or its salt is more preferably 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1,000 parts by mass or less. In the case of (B), the content of at least one selected from alginic acid and its salts, guar gum, xanthan gum, and tamarind gum per 100 parts by mass of carrageenan is preferably 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1,000 parts by mass or less. Note that "at least one type of content" as used here refers to the total amount of any two or more types of content present. In the case of (C), the total amount of the other three types of gums relative to 100 parts by mass of one type selected from guar gum, locust bean gum, xanthan gum, and tamarind gum is preferably 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1,000 parts by mass or less.

[0042] Furthermore, in case (2), the proportion of the total amount of the specific hydrophilic natural polymers in the topical skin preparation is preferably 5% by mass or more in order to enhance the effects of the present invention, and is preferably 50% by mass or less in order to ensure the amount of acidic substances and carbon dioxide generating substances, prevent a decrease in the foaming properties of the topical skin preparation of the present invention, and ensure the functionality of the topical skin preparation of the present invention, such as the feel of use and the effect of improving the condition of the skin. From this viewpoint, the proportion of the total amount of the specific hydrophilic natural polymers in the topical skin preparation is more preferably 10% by mass or more and 45% by mass or less, and is particularly preferably 12% by mass or more and 45% by mass or less.

[0043] Next, we will explain the case where (3) the product contains two or more polysaccharides or their derivatives selected from cellulose derivatives and starch derivatives.

[0044] In the case of (3), from the viewpoint of making the effects of the present invention even more reliable and remarkable, it is preferable to (a) contain a combination of at least one selected from cellulose derivatives and at least one selected from starch derivatives, or (b) contain a combination of two or more specific cellulose derivatives.

[0045] In the case of (i), for example, it is particularly preferable to include in combination at least one selected from hydroxyethylcellulose and its derivatives, hydroxypropylmethylcellulose and its derivatives, sulfonated cellulose derivatives, carboxymethylcellulose and its derivatives and their salts, carboxymethylethylcellulose and its salts, cellulose phthalate acetate, cationized cellulose, ethylcellulose, and croscarmellose and its salts as a cellulose derivative, and at least one selected from carboxymethyl starch and its salts and acrylic acid graft starch and its salts as a starch derivative. In the case of (i), it is particularly preferable to use at least one selected from carboxymethylcellulose and its derivatives and their salts as the cellulose derivative.

[0046] (b) For example, the following cases (X) or (Y) are preferred examples. (X) The cellulose derivative contains at least one selected from hydroxypropyl methylcellulose and its derivatives, and at least one selected from hydroxyethylcellulose and its derivatives and cationized cellulose. (Y)The cellulose derivative contains at least one selected from carboxymethylcellulose and its derivatives and their salts, and at least one selected from hydroxyethylcellulose and its derivatives, hydroxypropylcellulose and its derivatives, sulfonated cellulose derivatives, carboxymethylethylcellulose and its salts, cellulose phthalate acetate, cationized cellulose, ethylcellulose, and croscarmellose and its salts.

[0047] When a topical skin preparation contains two or more polysaccharides or their derivatives selected from cellulose derivatives and starch derivatives, as in (3), the content of any one of the other polysaccharides per 100 parts by mass of one polysaccharide is preferably 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1,000 parts by mass or less. Furthermore, when the topical skin preparation contains a combination of at least one selected from cellulose derivatives and at least one selected from starch derivatives, as in (a), from the viewpoint of making the effects of the present invention even more remarkable, it is preferable to contain 1 to 10,000 parts by mass of starch derivatives per 100 parts by mass of cellulose derivatives, more preferably 5 to 5,000 parts by mass, and particularly preferably 10 to 1,000 parts by mass.

[0048] Furthermore, when a topical skin preparation contains, as in (X) of (b), at least one selected from hydroxypropyl methylcellulose and its derivatives (the former) and at least one selected from hydroxyethylcellulose and its derivatives and cationized cellulose (the latter), it is preferable that the total amount of the latter be 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1,000 parts by mass or less, per 100 parts by mass of the total amount of the former.

[0049] Furthermore, when a topical skin preparation contains, as in (Y) of (b), at least one selected from carboxymethylcellulose and its derivatives and their salts (the former) as a cellulose derivative, and at least one selected from hydroxyethylcellulose and its derivatives, hydroxypropylcellulose and its derivatives, sulfonated cellulose derivatives, carboxymethylethylcellulose and its salts, cellulose phthalate acetate, cationized cellulose, ethylcellulose, and croscarmellose and its salts (the latter), it is preferable that the total amount of the latter be 1 to 10,000 parts by mass, more preferably 5 to 5,000 parts by mass, and particularly preferably 10 to 1,000 parts by mass, per 100 parts by mass of the total amount of the former.

[0050] Furthermore, in case (3), the proportion of the total amount of cellulose derivatives and starch derivatives in the topical skin preparation is preferably 5% by mass or more in order to enhance the effects of the present invention, and is preferably 50% by mass or less in order to ensure functionality such as the feel of the topical skin preparation and the effect of improving the condition of the skin. From this viewpoint, the proportion of the total amount of cellulose derivatives and starch derivatives in the topical skin preparation is more preferably 10% by mass or more and 45% by mass or less, and is particularly preferably 12% by mass or more and 45% by mass or less.

[0051] The topical skin preparation of the present invention, employing any of the following configurations (1) to (3), suppresses the amount of water evaporation from the skin after use compared to before use, compared to the case where a conventional combination of polysaccharides or their derivatives is employed. Alternatively, after using the topical skin preparation, whiteness, skin moisture content, and / or elasticity are increased compared to before use. As a result, skin condition such as moisture, elasticity, brightness, redness, smoothness, and / or a smooth feeling is improved. Furthermore, when the topical skin preparation of the present invention adopts any of the following compositions (1) to (3), the characteristic effect is that, in addition to the improvement of skin condition described above, the user experience is greatly improved. When the topical skin preparation of the present invention adopts any of the following compositions (1) to (3), it possesses the characteristics required for topical skin preparations that are mixed with water-containing substances and foamed, such as ease of mixing, ease of dissolving, ease of application, resistance to dripping, and / or ease of removal, compared to conventional combinations of polysaccharides or their derivatives. Furthermore, when the topical skin preparation of the present invention employs the following configurations (1) to (3), it has smooth foam, fine foam, no roughness, foam elasticity, foam retention, and a high level of carbonation sensation, or / or sustained carbonation sensation. For this reason, the topical skin preparation of the present invention offers a significantly improved user experience compared to conventional preparations employing combinations of polysaccharides or their derivatives. Furthermore, the topical skin preparation of the present invention, which has a long-lasting carbonated sensation, also provides a high degree of skin tightening. As a result of these effects, the topical skin preparation of the present invention, by adopting any of the following configurations (1) to (3), will exhibit the remarkable effect of "having a pleasant feel and improving the condition of the skin." The effects of the present invention are obtained by the agent of the present invention containing a specific combination of the polysaccharides (1) to (3) or their derivatives together with a solid acidic substance and a solid carbon dioxide generating substance. Therefore, for example, the effects cannot be obtained by an agent that contains one or both of the combinations of (1) to (3) together with water to form a viscous composition, and then mixes this viscous composition with a solid acidic substance and / or a solid carbon dioxide generating substance at the time of use.

[0052] The topical skin preparation of the present invention is more preferably to contain a water-soluble protein. Here, a water-soluble protein refers to a protein obtained by concentrating, separating, and purifying animal or plant-derived proteins, which has the property of easily dispersing or dissolving in water or various liquids. Specifically, it refers to a protein that can be uniformly dispersed or dissolved without forming clumps when added at 5% by mass or more to water at 25°C under 1 atmosphere. The water-soluble protein includes protein hydrolysates. As the hydrolysate, it is preferable to hydrolyze proteins derived from various organisms such as animals and fish using alkaline treatment or enzymatic treatment. Specific water-soluble proteins that can be used include hydrolyzed collagen such as casein, collagen, and gelatin, albumin, elastin, keratin, and sericin. These can be used individually or in combination of two or more. In particular, the topical skin preparation of the present invention is preferably to contain albumin, collagen, and hydrolyzed collagen as water-soluble proteins. Water-soluble proteins also play a role as foaming aids, and in particular, they strengthen the foam and keep the foam stable for a long period of time. Therefore, the addition of water-soluble proteins contributes to easier viscosity adjustment of topical skin preparations, improved solubility in water, and increased carbon dioxide generation, thus easily enhancing the skin condition improvement effect. The inventors have found that the effects of this water-soluble protein are enhanced by including polysaccharides or their derivatives, particularly two or more polysaccharides or their derivatives.

[0053] Furthermore, while the topical skin preparation of the present invention may contain only one type of water-soluble protein, it is also preferable to contain two or more types of water-soluble proteins. This is demonstrated, for example, in the comparison between Examples 13 and 14 and Example 17 described later. As is clear from these examples, compared to the case in which only albumin is contained as the water-soluble protein, the inclusion of collagen or hydrolyzed collagen together with albumin tends to improve skin texture, such as the moistness and smoothness of the skin after use, and also improves the feel of the mixture obtained by mixing the topical skin preparation with a water-containing substance. In particular, as will be clear from Example 14 described later, the foaming topical skin preparation of the present invention tends to improve ease of application, pleasant feeling upon application, and appearance when hydrolyzed collagen is included. Furthermore, as will be clear from the comparison of Examples 18 and 19 described later, hydrolyzed collagen, even when used alone, exhibits an effect equal to or greater than albumin in retaining carbon dioxide in the mixture of the topical skin preparation and the aqueous substance, and in improving the skin condition after use of the topical skin preparation.

[0054] When the topical skin preparation of the present invention contains a water-soluble protein, the amount of water-soluble protein in the topical skin preparation is preferably 0.01% by mass or more and 10% by mass or less, and more preferably 0.05% by mass or more and 8% by mass or less. A concentration of 0.01% by mass or more and 10% by mass or less is preferable because it easily increases the strength of the bubbles containing the water-soluble protein, making it easier to obtain effects such as maintaining the foam's stability for a long period of time.

[0055] Furthermore, when the topical skin preparation contains a water-soluble protein, from the viewpoint of further enhancing the carbon dioxide retention capacity when the topical skin preparation of the present invention is dissolved in water, the content of the water-soluble protein is preferably 0.1 parts by mass or more, and more preferably 1 part by mass or more and 50 parts by mass or less, per 100 parts by mass of polysaccharide or its derivative.

[0056] The topical skin preparation of the present invention may contain various components other than the solid acidic substance, the solid carbon dioxide generating substance, polysaccharides or their derivatives, and water-soluble proteins, depending on the application and purpose. Such components will be further described below.

[0057] The topical skin preparation of the present invention preferably uses a surfactant, such as a nonionic surfactant, anionic surfactant, cationic surfactant, or amphoteric surfactant, from the viewpoint of retaining the foam generated. In this case, from the viewpoint of storage stability, the surfactant used is preferably in the form of a water-free solution, solid, flake, granule, fine granule, or powder. Natural surfactants are preferred as the surfactants mentioned above. Natural surfactants refer to surfactants derived from plants and animals, and examples include phospholipids such as lecithin, lanolin, cholesterol, saponin, sphingolipids, pectin, dipotassium glycyrrhizate, and plant-extracted amino acid-based surfactants. The topical skin preparation of the present invention preferably contains 0.001% to 10% by mass of natural surfactants, and more preferably 0.005% to 8% by mass.

[0058] Among the natural surfactants listed above, phospholipids, saponins, pectin, glycyrrhizic acid, or salts thereof are preferred for use in the present invention, and it is particularly preferred that the natural surfactant contains an extract containing saponins and / or glycyrrhizic acid or a salt thereof. Saponins are glycosides widely distributed in plants and are a general term for a group of compounds in which steroids or triterpenoids are the non-sugar portion. Depending on the type of aglycone (non-sugar portion of the glycoside), they can be broadly classified into triterpenoid saponins and steroid saponins. A common property of saponins is that their aqueous solutions have high foaming properties.

[0059] As mentioned above, saponins are known to have foaming properties. The inventors have found that by adding an extract containing saponins instead of water-soluble proteins, improvements in the long-term stability of foam, the resulting reduced dripping and ease of mixing, and improvements in skin condition such as moisture and elasticity can be obtained at a level equivalent to or better than that of water-soluble proteins. Topical skin preparations containing water-soluble proteins may be difficult to use for users with allergies, for example, but saponin-containing extracts can be effectively used as a substitute for these water-soluble proteins. Furthermore, the addition of saponin-containing extracts has the effect of increasing carbon dioxide generation, which can contribute to effectively promoting blood circulation in the skin. The inventors have found that by including polysaccharides or their derivatives, particularly two or more polysaccharides or their derivatives, the effects of adding saponin-containing extracts, especially improvements in usability and skin condition, are enhanced.

[0060] It is preferable to use plant-derived extracts as saponin-containing extracts for the topical skin preparation of the present invention. Examples of plants that contain triterpenoid saponins include soybeans, loofah, adzuki beans, kidney beans, spinach, sugar beets, grapes, balloon flowers, licorice, senega, quillaja, soapberry, ginseng, tea seeds, and pagoda tree. Examples of plants that contain steroid saponins include plants of the lily family, plants of the yam family, Anemarrhena asphodeloides, and Ophiopogon japonicus. The agent of the present invention preferably uses an extract of one or more of the above-mentioned plants that contain triterpenoid saponins as an extract containing saponins, and preferably contains an extract of one or more plants selected from soapberry, soybean, licorice, and loofah, and in particular preferably contains an extract of soapberry. Here, soapberry refers to plants belonging to the genus Sapindus of the family Sapindaceae, such as S. mukurossi and S. delavayi.

[0061] Parts of the plant used as raw materials for the extract include the whole plant, leaves (leaf blade, petiole, etc.), fruits (mature, immature, etc.), seeds, flowers (petals, ovary, etc.), stems, rhizomes, roots, tubers, etc. In the present invention, when using a soapberry extract as the saponin-containing extract, it is preferable that it be an extract of the fruit and / or pericarp of the soapberry, and particularly preferable that it be an extract of the pericarp.

[0062] The extract can be obtained by using the whole plant or the aforementioned parts as they are, or by cutting, crushing, grinding, or squeezing them, or by drying or powdering the processed materials. These processing methods can be used individually or in combination of two or more.

[0063] Examples of solvents used for extraction include water; methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, hexylene glycol, glycerin, methyl acetate, ethyl acetate, isopropyl acetate, ethyl ether, and acetone. These can be used individually or in combination of two or more. From a safety standpoint, it is preferable to use water, ethanol, or a mixture thereof, which are harmless to the human body, as the extraction solvent. Extraction only needs to be performed at a temperature below the boiling point of the extraction solvent, and the extraction time can be appropriately changed depending on the extraction temperature. The extract may contain water as the extraction solvent, but in the case of the topical skin preparation of the present invention, if it is a one-dose topical skin preparation, the acidic substance and the carbon dioxide generating substance react during storage, and unless it contains the amount of water necessary to generate carbon dioxide, it will not substantially contain water, so it is also possible to use an extraction solvent that contains water.

[0064] The extract is filtered to remove impurities and then incorporated into the topical skin preparation of the present invention in a solid form such as a powder. Methods for forming a solid include, for example, freezing or spray-drying the extract obtained by the above-mentioned solvent extraction. Before forming the extract into a solid, further purification may be performed, provided that the physiological effects of the saponin are not impaired.

[0065] From the viewpoint of further enhancing the above effects, if the topical skin preparation of the present invention contains an extract containing saponins, the content thereof is preferably 0.001% by mass or more and 10% by mass or less in the topical skin preparation, and more preferably 0.005% by mass or more and 8% by mass or less. The content of the extract being 0.001% by mass or more and 10% by mass or less is preferable from the viewpoint of achieving both long-term stability of the foam and improvement of skin condition.

[0066] Furthermore, examples of glycyrrhizic acid and its salts as natural surfactants in the present invention include dipotassium glycyrrhizate (GK2). As will be described later, glycyrrhizic acid and its salts also function as anti-inflammatory agents and whitening agents. In the present invention, when glycyrrhizic acid and its salts are used as natural surfactants (or anti-inflammatory agents, whitening agents), as will be clear from the comparison of Examples 4 and 5 described later, carbon dioxide is more easily retained for a long time in the mixture of the topical skin preparation and the water-containing substance, and the amount of carbon dioxide generated can also be increased. In addition, the moisture content of the stratum corneum of the skin increases, and the effect of improving skin condition such as increased redness is enhanced, making it possible to improve the feel of the topical skin preparation. The preferred content of glycyrrhizic acid and its salts in the topical skin preparation of the present invention is the same as the preferred content of the anti-inflammatory agent described later.

[0067] Furthermore, it is preferable that the topical skin preparation of the present invention contains at least one selected from a bactericide, an anti-inflammatory agent, and a skin whitening agent.

[0068] Bactericides are substances that have bactericidal, bacteriostatic, or antibacterial effects and do not cause skin problems when incorporated into topical skin preparations. Examples include salicylic acid and its salts or salicylic acid derivatives; antibiotics such as erythromycin, clindamycin, gentamicin, penicillin, chloramphenicol, and tetracycline; benzoyl peroxide; nadifloxacin; ethanol; benzalkonium chloride; sulfur; parahydroxybenzoate esters; hinokitiol; triclosan; homosulfamine; chloramine T; catechins and their derivatives; and chitin and chitosan derivatives. Furthermore, extracts with antibacterial properties can also be used as antibacterial agents. Examples of such extracts include those from fennel, phellodendron bark, tea, rosehip, chamomile, orange, yarrow, turmeric, gardenia, clove, sage, saxifrage, clove, eucalyptus, cypress, and cedar. These can be used individually or in combination of two or more.

[0069] Of these disinfectants, salicylic acid and its salts or salicylic acid derivatives are particularly preferred, and salicylic acid is especially preferred. As will be clear from the examples described later, using disinfectants such as salicylic acid in the topical skin preparation of the present invention makes it possible to improve the moisture content and elasticity of the stratum corneum of the skin after use. From the viewpoint of further enhancing this effect, if the topical skin preparation of the present invention contains a bactericide, the amount of the bactericide is preferably 0.001% by mass or more and 20% by mass or less, and more preferably 0.005% by mass or more and 10% by mass or less.

[0070] Anti-inflammatory agents are substances that have an anti-inflammatory effect. Examples include glycyrrhizic acid and its salts, as well as their derivatives, as natural surfactants. Other examples of anti-inflammatory agents include glycyrrhetinic acid and its salts, mefenamic acid and its salts, phenylbutazone, indomethacin, ibuprofenic acid and its salts, ketoprofen, allantoin, guaiazulene, and their derivatives, ε-aminocaproic acid, zinc oxide, diclofenac sodium, and proanthocyanidins. Furthermore, extracts with anti-inflammatory properties can also be used as anti-inflammatory agents. Examples of such extracts include extracts from plants and animals such as Saxifraga stolonifera, licorice, aloe, Lithospermum erythrorhizon, Salvia japonica, Arnica montana, chamomile, birch, St. John's wort, eucalyptus, peach leaf, pine bark, grape seed, and cranberry. These can be used individually or in combination of two or more.

[0071] Of these anti-inflammatory agents, it is particularly preferable to use glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, and their derivatives. For the reasons mentioned above, it is especially preferable to use glycyrrhizic acid and its salts, and in particular, dipotassium glycyrrhizinate (GK2). In the topical skin preparation of the present invention, the use of an anti-inflammatory agent can suppress skin inflammation and prevent acne and rough skin. From the viewpoint of further enhancing these effects, if the topical skin preparation of the present invention contains an anti-inflammatory agent, its content is preferably 0.001% by mass or more and 20% by mass or less, and more preferably 0.005% by mass or more and 10% by mass or less, in the topical skin preparation. When GK2 is used in the topical skin preparation of the present invention, as is evident from Example 7 described later, not only is a high effect of improving skin whiteness obtained, but also a high effect of improving skin condition, such as improving stratum corneum moisture content and elasticity. Furthermore, as is evident from the descriptions in 16 and 17 described later, the topical skin preparation using GK2 also has excellent usability, such as ease of mixing and resistance to dripping.

[0072] Whitening agents primarily consist of substances that possess tyrosinase activity or melanin-decolorizing activity. Examples include L-cysteine ​​and its derivatives, ascorbic acid and its derivatives, tranexamic acid derivatives, glabridin, liquiritin, isoliquiritin, hydroquinone, arbutin, kojic acid, and placenta. Glycyrrhizic acid or its salts, glycyrrhetinic acid and its salts, and their derivatives can also be used as whitening agents. Furthermore, extracts with whitening properties can also be used as whitening agents. Examples of such extracts include mulberry bark extract, angelica extract, spicebush extract, cinquefoil extract, Sophora flavescens extract, hawthorn extract, white lily extract, hop extract, and wild rose extract. These can be used individually or in combination of two or more.

[0073] Of these whitening agents, it is preferable to use one or more selected from arbutin, placenta, glycyrrhizic acid or its salts, ascorbic acid and its derivatives.

[0074] The arbutin used in this invention is a compound also known by its systematic name 4-(β-D-glucopyranosyloxy)phenol. As is evident from Example 10 described later, when arbutin is used in the topical skin preparation of the present invention, not only is a high effect of improving skin whiteness obtained, but also a high effect of improving skin condition such as skin moisture and elasticity is obtained. Furthermore, as is evident from the description in Examples 10 and 16 described later, the topical skin preparation using arbutin is also excellent in terms of ease of application, pleasantness during application, spreadability, and ease of removal.

[0075] Placenta is a general term for extracts of growth factors and other nutrients that promote cell division from animal placentas, particularly preferably from pigs, horses, cows, sheep, and humans; extracts of nutrients from fish ovarian membranes; and extracts of nutrients from plant germs. As is clear from the description in Example 15 below, the topical skin preparation of the present invention containing placenta tends to reduce the amount of water evaporation after application and tends to increase smoothness and suppleness. In the present invention, any type of placenta can be used, but animal-derived placenta or fish-derived placenta can be preferably used.

[0076] From the viewpoint of further enhancing the above-mentioned effects, if the topical skin preparation of the present invention contains a whitening agent, the amount of the whitening agent is preferably 0.001% by mass or more and 30% by mass or less, and more preferably 0.005% by mass or more and 20% by mass or less, in the topical skin preparation.

[0077] In the topical skin preparation of the present invention, other active ingredients can be used in place of, or in addition to, the saponin-containing extracts, bactericides, anti-inflammatory agents, and whitening agents mentioned above. Examples of such active ingredients include gold leaf, pearl powder, mud, charcoal, gypsum, enzymes, herbs, seaweed, yogurt, whey, sake, fermented products such as koji, moisturizing ingredients such as honey, propylene glycol, polyethylene glycol, sorbitol, sodium lactate, and sodium pyrrolyrroidone carboxylate, plant components such as licorice, and vitamins. Among these, gold leaf and pearl powder are particularly preferred. As is clear from the description in Example 11 below, using gold leaf improves the user experience, such as the pleasant feeling when applied and the appearance, and also provides an effect of improving skin condition. Also, as is clear from the description in Example 12 below, using pearl powder provides an effect of improving skin condition, such as skin brightness, and also improves the user experience.

[0078] Pearl powder is a powder obtained by sieving cultured or natural pearls, which are spherical or amorphous metabolic products formed within the bodies of marine shellfish such as Akoya oysters, black-lipped oysters, white-lipped oysters, mabe oysters, and abalone, and freshwater shellfish such as freshwater mussels, after grinding them using known methods such as ball mills, jet mills, and turbo mills. When pearl powder is included, its content is preferably 0.0001% by mass or more and 10% by mass or less in the topical skin preparation. When gold leaf is included, its content is preferably 0.0001% by mass or more and 10% by mass or less in the topical skin preparation.

[0079] The foaming topical skin preparation of the present invention may also contain one or more components commonly used in topical skin preparations, such as polysaccharides and their derivatives and water-soluble proteins, thickeners other than polysaccharides and water-soluble proteins; excipients, granulating agents; pH adjusters; oils and fats; fragrances; colorants; antioxidants; antibacterial and antifungal agents; alcohols, polyhydric alcohols; inorganic salts; lubricants; solvents; and extracts of plants and animals.

[0080] Examples of thickeners other than polysaccharides and their derivatives and water-soluble proteins include hydrophilic synthetic polymers such as polyvinyl alcohol, acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, poloxamer (Pluronic®), polyvinylpyrrolidone, and acrylate / alkyl methacrylate copolymer as organic thickeners, and hydrophilic thickening compounds such as laponite, bentonite, smectite, silica, and talc as inorganic thickeners. Note that acrylate / alkyl methacrylate copolymer is a compounding component that functions as a polymer emulsifier, and for example, (acrylates / alkyl acrylate (C10-30)) crosspolymer can be used.

[0081] As excipients or granulating agents, for example, powders such as lactose, powdered sugar, xylitol, D-sorbitol, glucose, D-mannitol, fructose, sucrose, sucrose, and urea can be used individually or in combination of two or more, without particular limitations. When such excipients and / or granulating agents are included, their content in the topical skin preparation of the present invention is preferably 10% by mass or more, and more preferably 20% by mass or more and 88% by mass or less.

[0082] In the topical skin preparation of the present invention, the total content of other components other than the acidic substance, the carbon dioxide generating substance, the polysaccharide or its derivative, the water-soluble protein, the natural surfactant, the bactericide, the anti-inflammatory agent, the whitening agent, the excipient or granulating agent is preferably 40% by mass or less, and more preferably 30% by mass or less.

[0083] In the case of the topical skin preparation of the present invention, (4) in addition to polysaccharides or derivatives thereof, if it also contains at least one selected from the inorganic hydrophilic thickening compound and the organic hydrophilic synthetic polymer as a thickening agent other than the polysaccharides and derivatives thereof and water-soluble proteins described above, the effect of "good usability and improvement of skin condition" is significant, similar to the case of (1) to (3) in which two or more polysaccharides or derivatives thereof are combined. The effects of the present invention are obtained by the agent of the present invention containing a polysaccharide or its derivative and the above-mentioned hydrophilic thickening compound or hydrophilic synthetic polymer together with a solid acidic substance and a solid carbon dioxide generating substance. Therefore, the effects of the present invention cannot be obtained, for example, by an agent that contains, a viscous composition containing either or both of the combination of the polysaccharide or its derivative of (4) above and the hydrophilic thickening compound or the above-mentioned hydrophilic synthetic polymer together with water, and this viscous composition is mixed with a solid acidic substance and / or a solid carbon dioxide generating substance when used.

[0084] In the present invention, (4) when the preparation contains an inorganic hydrophilic thickening compound or a hydrophilic synthetic polymer which is an organic thickening agent, preferred examples of polysaccharides or derivatives thereof contained in the topical skin preparation include hydrophilic natural polymers, cellulose derivatives, or starch derivatives. Examples of such hydrophilic natural polymers include alginic acid and its salts, carrageenan, locust bean gum, tamarind gum, and guar gum.

[0085] In particular, the polysaccharide or derivative thereof in (4) is preferably at least one selected from alginic acid and its salts, carrageenan, locust bean gum, tamarind gum, guar gum, ethylcellulose, carboxymethylcellulose and its derivatives and their salts, hydroxyethylcellulose and its derivatives, hydroxypropylmethylcellulose and its derivatives, sulfonated cellulose derivatives, carboxymethylethylcellulose and its salts, cellulose phthalate acetate, cationized cellulose, and croscarmellose and its salts, and is especially preferably at least one selected from alginic acid and its salts, carrageenan, carboxymethylcellulose and its derivatives and their salts, guar gum, hydroxyethylcellulose and its derivatives, and cationized cellulose.

[0086] Furthermore, in the present invention, if (4) the above-mentioned inorganic hydrophilic thickening compound or hydrophilic synthetic polymer which is an organic thickening agent is included, it is also preferable to use xanthan gum as a polysaccharide or a derivative thereof. In this case, it is particularly preferable to combine xanthan gum with talc.

[0087] In the case of (4), if the topical skin preparation of the present invention contains a specific hydrophilic natural polymer, cellulose derivative, or starch derivative as a polysaccharide or its derivative, the amount of an inorganic hydrophilic thickening compound or a hydrophilic synthetic polymer which is an organic thickening agent is preferably 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or more, and particularly preferably 10 parts by mass or more and 1,000 parts by mass or less, per 100 parts by mass of the hydrophilic natural polymer, cellulose derivative, or starch derivative, is the total amount if two or more of these are contained. Similarly, if two or more of these are contained, the amount of the hydrophilic thickening compound or hydrophilic synthetic polymer is the total amount. Furthermore, if the product contains specific types of hydrophilic natural polymers, cellulose derivatives, starch derivatives, hydrophilic thickening compounds, or hydrophilic synthetic polymers, the amount of the above-mentioned hydrophilic natural polymers, cellulose derivatives, starch derivatives, hydrophilic thickening compounds, or hydrophilic synthetic polymers may be equal to the amount of the specific type of hydrophilic natural polymer, cellulose derivative, starch derivative, hydrophilic thickening compound, or hydrophilic synthetic polymer (the same applies hereinafter).

[0088] In the topical skin preparation of the present invention, the total content of the above-mentioned specific hydrophilic natural polymer, cellulose derivative, starch derivative, hydrophilic thickening compound, and hydrophilic synthetic polymer is preferably 5% by mass or more and 50% by mass or less, more preferably 10% by mass or more and 45% by mass or less, and particularly preferably 12% by mass or more and 45% by mass or less.

[0089] The dosage form of the topical skin preparation of the present invention is usually solid, and can be powder, granules, fine granules, pellets, or a combination of two or more of these. Powder form is preferred due to reduced manufacturing costs and ease of dissolution during use.

[0090] For example, when the topical skin preparation of the present invention is in granular form, the entire preparation may be in granular form, or only a portion of it may be in granular form. When only a portion is in granular form, the acidic substance and / or the carbon dioxide generating substance may be in granular form. In this case, the granules may contain other components (excipients, granulating agents, polysaccharides or their derivatives, water-soluble proteins, etc., one or more of the various components described above). Furthermore, components other than the acidic substance and the carbon dioxide generating substance may also be in granular form.

[0091] For example, when obtaining solid granules of the acidic substance and / or the carbon dioxide generating substance by granulating a mixture of the acidic substance and / or the carbon dioxide generating substance and other components, there are no particular restrictions on the content of the other components, but it is preferable that it be less than 80% by mass in the granules. If the other components are present in a content exceeding 80% by mass, the effervescence will be reduced, which is undesirable.

[0092] The method for producing the granules is not limited to this embodiment, and they can be produced according to conventional methods such as dry crushing and granulation, wet crushing and granulation, fluidized bed granulation, high-speed stirring granulation, and extrusion granulation.

[0093] For example, when using a low-melting-point compound as a granulating agent as a matrix base, the low-melting-point granulating agent is melted by heating in a container such as a beaker, and the acidic substance and / or carbon dioxide generating substance, along with other components as needed, are added and thoroughly stirred and mixed. Appropriate additives may be added as needed. This mixture is then stirred further while gradually cooling at room temperature and left to stand until it solidifies. Once it has solidified to some extent, it may be rapidly cooled in a refrigerator or the like.

[0094] Alternatively, for example, the above material may be introduced into a fluidized bed granulator, mixed with airflow for several minutes, and then granulated by spraying water onto it.

[0095] If a low-melting-point compound is not used as the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker. The acidic substance and / or the carbon dioxide generating substance, as well as other components as needed, are dissolved or dispersed in this mixture and thoroughly mixed. After heating in an oven or the like to remove the solvent, the mixture is dried. Once completely solidified, it is crushed, sieved to standardize the particle size, and then obtained as granules.

[0096] As described above, the solidified acidic substance or solid carbon dioxide generating substance can take any shape without particular limitation, such as irregular shapes, planar shapes, polyhedral shapes, spherical shapes, teardrop shapes, fibrous shapes, cylindrical shapes, or fine powder shapes. Furthermore, a wide range of particle sizes can be used without particular limitation. In particular, a particle size distribution of approximately 1,000 μm is more preferable from the viewpoint of ease of handling and ease of mixing with water-containing substances. The particle size distribution in this invention can be determined by a conventional laser diffraction / scattering method.

[0097] In the present invention, it is preferable that the acidic substance and the carbon dioxide generating substance are contained in the same agent, and that they are formulated so as not to physically come into contact with each other within the same agent, and that they coexist. The means of achieving this coexistence are not particularly limited and can be broadly applied.

[0098] When the acidic substance and the carbon dioxide generating substance are formulated so that they do not physically come into contact with each other, for example, a coating layer may be provided on either one or both of the acidic substance and the carbon dioxide generating substance, or either one or both of the acidic substance and the carbon dioxide generating substance may be encapsulated. Alternatively, a layer not containing the acidic substance or the carbon dioxide generating substance may be sandwiched between the acidic substance and the carbon dioxide generating substance so that they do not come into direct contact, and then compression molded.

[0099] The following describes, but is not limited to, the means by which the acidic substance and the carbon dioxide generating substance can coexist within the same agent.

[0100] [Coat layer formation] As a method for forming the coating layer, for example, a method may be used in which the coating layer is formed using at least one of an acidic substance or a carbon dioxide generating substance. By providing a coating layer, even if the acidic substance, the carbon dioxide generating substance, and other components are present together in the same agent, there is no risk of unexpected carbon dioxide generation during manufacturing or storage, which is preferable in terms of stability and durability.

[0101] The coating agent preferred for forming the above-mentioned coating layer is not particularly limited as long as it has low reactivity with the acidic substance or the carbon dioxide generating substance. Examples include oils and fats, fatty acids, fatty acid salts, acetylcellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, hydroxypropylmethylcellulose, methyl methacrylate-methacrylic acid copolymer, ethyl acrylate-methacrylic acid copolymer, gum arabic, sodium alginate, soluble starch, hydroxypropylcellulose, wheat starch, sucrose, lactose, citrate, etc. In particular, when coating with an acidic substance such as citric acid, it is preferable to use a citrate such as calcium citrate. Alternatively, a solid hydrocarbon wax, solid oil, etc., which dissolve at a certain temperature or higher when heated, may be used to form the coating layer.

[0102] The amount of coating agent used for acidic substances and / or carbon dioxide generating substances is preferably 1 to 20% (w / w), and more preferably 1 to 10% (w / w), relative to the acidic substance or carbon dioxide generating substance.

[0103] The coating method for the coating layer can be any method commonly used for coating particles. For example, coating may be performed simultaneously with granulation by spray granulation or tumbling granulation, or the powder or granules may be coated using methods such as oil coating, granulation coating, transport layer method, pan coating, tumbling coating, fluid coating, or dry coating. If excessive heat or physical force is applied during coating, the acidic substance or carbon dioxide generating substance will be destroyed, and the resulting coating film will break down, making it difficult to uniformly coat the entire surface of the acidic substance or carbon dioxide generating substance with the lipid powder. Furthermore, the acidic substance or carbon dioxide generating substance may leak onto the surface, causing solidification due to moisture absorption, or adversely affecting other components during compounding. Therefore, the coating conditions must be such that the coating layer and the object to be coated are not destroyed.

[0104] [Encapsulation] When encapsulating acidic substances and / or carbon dioxide-generating substances, known methods may be used without particular limitation.

[0105] As for the encapsulation method, known methods can be applied without particular limitation, and the encapsulation materials include gelatin, starch, gum arabic, methylcellulose, acrylic acid ester, methacrylic acid ester, vinyl acetate, polyvinyl alcohol, silicone resin, solid wax, polyethylene, fatty acids, higher alcohols, etc., as well as multilayers of surfactants such as liposomes, but are not limited to these and can be widely used. For example, it is also preferable that the basic structure of the capsule be a resin capsule consisting of a homopolymer or copolymer formed from one or more monomers selected from acrylic acid ester, methacrylic acid ester, vinyl acetate, and styrene, or a copolymer formed from the monomer and a monomer selected from acrylic acid, methacrylic acid, divinylbenzene, and ethylene glycol dimethacrylate. Such microcapsules can be made by emulsifying the contents and the constituent monomers of the polymer constituting the outer shell of the capsule in a reaction solvent such as water, and then adding a polymerization initiator such as azobisisobutyronitrile or benzoyl peroxide to carry out emulsion polymerization. Suitable examples of surfactants used in such emulsification include, for example, Hexlite, which is sold under the name "Laponite XLG". The resulting microcapsules can be separated by means of centrifugation or other methods, and optionally washed, to produce the microcapsules of the present invention.

[0106] [Compression molding] As a compression molding method, a third layer consisting of substances other than the acidic substance and the carbon dioxide generating substance (e.g., excipients, thickeners, etc.) may be sandwiched between the first layer containing the acidic substance and the second layer containing the carbon dioxide generating substance so that they do not come into direct contact with each other, and then compression molding may be performed. The compression-molded dosage form can be any solid form, such as tablets, spheres, or plates. The acidic substance and the carbon dioxide generating substance used may be used as they are, or a coating layer may be applied to either the first layer or the second layer or more using the method described above, or encapsulated acidic substance or carbon dioxide generating substance may be used. The compression molding method is not particularly limited and any known method can be applied.

[0107] The topical skin preparation of the present invention may exclude the following topical skin preparations. "A one-component topical skin preparation containing at least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener, and not containing water, wherein the thickener is contained in an amount of 12 to 45% by mass of the total topical skin preparation, and the thickener is used in combination with albumin and other thickeners, and is mixed with a water-containing liquid when the topical skin preparation is used." Examples of thickeners include hydrophilic synthetic polymers such as polyvinyl alcohol, hydroxyethylcellulose, hydroxypropylmethylcellulose, sulfonated cellulose derivatives, acrylates / alkyl acrylate crosspolymers, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymers, carboxymethylcellulose, cationized cellulose, and Pluronic acid; hydrophilic natural polymers such as starch, xanthan gum, sodium alginate, succinoglycan, carrageenan, guar gum, locust bean gum, and celluloses; hydrophilic thickening compounds such as hydrophilic protein compounds such as chondroitin sulfate, casein, collagen, gelatin, and albumin; and hydrophilic clay minerals such as laponite, bentonite, and smectite.

[0108] <Forms of use for topical skin preparations> The topical skin preparation of the present invention generates foam when mixed with a water-containing substance on the palm of the hand or in a container during use. The topical skin preparation of the present invention may be used as a single-dose topical skin preparation, or as a two-dose preparation comprising a water-containing substance and a kit. When the topical skin preparation of the present invention is a single-dose preparation, as described above, the topical skin preparation is usually a solid composition, and is more preferably in the form of a solid, granular, fine-granular, or powder form. It is particularly preferably in the form of a granular, fine-granular, or powder form due to its ease of mixing with water-containing substances and its ease of foaming. Furthermore, when the topical skin preparation of the present invention is a single-dose preparation, it is usually substantially water-free. Here, substantially water-free means that it does not contain the amount of water necessary for the reaction between the acidic substance and the carbon dioxide-generating substance during storage of the topical skin preparation to generate carbon dioxide. Specifically, the amount of water contained in the topical skin preparation of the present invention is 15% by mass or less, preferably 10% by mass or less, and more preferably 8% by mass or less. When the topical skin preparation of the present invention is a two-part kit consisting of an aqueous substance and an agent, the agent containing the acidic substance, the carbon dioxide generating substance, and at least one type of polysaccharide is usually a solid composition, more preferably in the form of a solid, granular, fine granule, or powder, and particularly preferably in the form of a granular, fine granule, or powder due to its ease of mixing with the aqueous substance and ease of foaming. Furthermore, when the topical skin preparation of the present invention is a two-part kit, the solid composition usually contains substantially no water. Here, substantially no water means that it does not contain the amount of water necessary for the acidic substance and the carbon dioxide generating substance to react and generate carbon dioxide during storage of the topical skin preparation. Specifically, the amount of water contained in the topical skin preparation of the present invention is 15% by mass or less, preferably 10% by mass or less, and more preferably 8% by mass or less. When the topical skin preparation of the present invention is a single-part kit, the user usually prepares the aqueous substance for mixing with the topical skin preparation, and when it is a two-part kit, as described above, the topical skin preparation of the present invention and the aqueous substance constitute the kit. When a topical skin preparation is in a single dosage form, a liquid containing water is often used as the hydrated substance. When it is in a two-dosage form, examples of the hydrated substance include liquids or gels containing water. Liquids are preferred as the hydrated substance, liquids with low viscosity are more preferred, and liquids with no viscosity are particularly preferred. It is preferable that the hydrated substance substantially does not contain the aforementioned thickening agents.Specifically, the content of the thickening agent in the aqueous substance is preferably 0.5% by mass or less, more preferably 0.1% by mass or less, and particularly preferably 0.01% by mass or less. In particular, when the topical skin preparation is in two-part form, mixing the topical skin preparation with a liquid, especially a liquid with relatively low viscosity, is preferable to mixing it with a gel, as this allows the effects of the present invention to be achieved more effectively. Mixing the topical skin preparation of the present invention with a gel or a liquid with relatively high viscosity is undesirable because it is difficult to mix the two preparations and it takes a long time to foam. Specifically, the viscosity of the aqueous substance at 25°C is preferably 50,000 mPa·s or less, more preferably 30,000 mPa·s or less, particularly preferably 10,000 mPa·s or less, and even more preferably 5,000 mPa·s or less. This viscosity can be measured with the viscometer used in the following examples. In addition, the water content in the aqueous substance may be 10% by mass or more, and preferably 30% by mass or more. More preferably, the moisture content is 40% by mass or more, even more preferably 50% by mass, particularly preferably 70% by mass or more, and especially preferably 80% by mass or more. If the moisture content is less than 10% by mass, carbon dioxide gas will not be easily generated when the topical skin preparation is mixed with the water-containing substance, and effects such as promoting blood flow during use will not be obtained. Here, high lower limits such as 70% by mass or 80% by mass or more can be adopted for both single-dose and double-dose formulations, but are particularly preferred for single-dose formulations.

[0109] When the topical skin preparation of the present invention is in a single-dose form, it has the advantage of being less expensive and easier for the user to handle compared to a two-dose form. In the case of a single-dose form, the water-containing substance used in the present invention can be a liquid containing water that is commonly used in cosmetics, pharmaceuticals, etc., or in general households. The liquid containing water may be water itself. Specifically, examples include tap water, distilled water, membrane-filtered water, ion-exchanged water, deep-sea water, as well as alcoholic beverages such as sake and wine, beverages such as soy milk, drinking yogurt, acerola juice, sports drinks, and carbonated water, and rice water. These may be used individually or mixed in groups of two or more.

[0110] Furthermore, when the topical skin preparation of the present invention is combined with a water-containing substance to form a two-part preparation, the water-containing substance may be a liquid or gel containing water, as described above. This includes water or water-containing liquids as mentioned above, as well as any other substances to which optional components have been added. These components may include known substances found in the liquid preparation of a two-part topical skin preparation, such as humectants, surfactants, pH adjusters, volatile alcohols, oils and fats, fragrances, and animal and plant extracts. For example, as humectants, polyglycerins such as glycerin, diglycerin, triglycerin, and tetraglycerin; polyhydric alcohols such as ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1,3-propanediol, sorbitol, and polyglycerin derivatives; polyoxyalkylene alkyl glucosides; sodium lactate; sodium pyrrolidone carboxylate; almonds; avocados; marsh marigolds; aloe vera; mallow; ononis; oats; licorice; quince seeds; Sophora flavescens; and gardenias. Examples of plant extracts include grapefruit, watercress, gentian, geranium, burdock, wheat, asarum, cactus, soapwort, hawthorn, rehmannia, spiraea, ginger, mallow, mulberry, thyme, cordyceps, houttuynia cordata, mint, adlay, witch hazel, rose, cypress, coltsfoot, grape, prune, loofah, linden, hops, pine, quince, horse chestnut, lemon balm, cornflower, lily, lime, lavender, apple, rice and rice bran, blackcurrant, sedge, wild rose, Eleutherococcus senticosus, and seaweed, and one or more of these can be used.

[0111] The amount of aqueous substance used is not particularly limited and can be used in a wide range of amounts, but for example, it is preferable to add 1 to 10 times the mass of the topical skin preparation, and more preferably 2 to 5 times the mass. Adding more than 1 times the amount of liquid allows for rapid dissolution of the topical skin preparation and generates a sufficient amount of carbon dioxide. On the other hand, adding no more than 10 times the amount of liquid prevents the topical skin preparation from dripping due to a decrease in viscosity.

[0112] While there are no particular restrictions on the temperature of the water-containing substance used, it is especially preferable to cool it beforehand, as this enhances the effectiveness of the active ingredients in the topical skin preparation. From the standpoint of ease of application and user convenience, it is preferable to use water or tap water at room temperature.

[0113] There are no particular restrictions on the method of storing topical skin preparations, as long as they are stored in a way that prevents moisture from being absorbed and contact with other substances. The shape of the storage container can be appropriately selected depending on the purpose, and examples include cup-shaped, tube-shaped, bag-shaped, bottle-shaped, stick-shaped, pump-shaped, jar-shaped, and can-shaped containers. Furthermore, the materials that make up the storage container can be, for example, plastic, glass, aluminum, paper, various polymers, etc., either individually or in combination of two or more, but are not limited to these.

[0114] Specific examples of containers that are preferable in terms of airtightness, storage stability of contents, and manufacturing cost include storage containers such as aluminum sticks and aluminum bags with the inner surface laminated with polyethylene terephthalate, resealable stand pouches, and storage containers made of polyethylene terephthalate with a lid heat-sealed with aluminum film laminated with polyethylene terephthalate.

[0115] As is clear from the descriptions of the examples below, the topical skin preparation of the present invention provides a pleasant feel and excellent skin condition improvement effects. Examples of pleasant feel include the ease of mixing the mixture of the topical skin preparation and the aqueous substance with the skin, ease of application, resistance to dripping, ease of removal, smoothness of the foam, fineness of the foam, uniformity of the foam (lack of powdery grittiness), elasticity of the foam, foam retention, carbonation sensation (stimulation), and persistence of the carbonation sensation. Furthermore, skin condition improvement effects include improved moisture, elasticity, brightness, redness, smoothness, firmness, whiteness, increased stratum corneum moisture content, and suppression of water evaporation. As is clear from Example 24 below, the topical skin preparation of the present invention may also have the effect of reducing the appearance of wrinkles.

[0116] <Uses of topical skin preparations> The topical skin preparation of the present invention promotes increased skin blood flow, and by utilizing the above effects, it provides whitening, skin texture improvement, freckle reduction, skin rejuvenation, skin tightening, localized slimming, skin cleansing, skin conditioning, skin texture refinement, skin health, prevention of rough skin, skin tightening, skin moisturizing, skin replenishment and retention of skin moisture and oil, skin flexibility, skin protection, skin dryness prevention, skin softening, skin firmness, skin radiance, skin smoothing, and sunspots and blemishes. This invention can be suitably used not only in cosmetics aimed at preventing blemishes and reducing the appearance of fine lines caused by dryness, but also in quasi-drugs, pharmaceuticals, and other medicines aimed at preventing rough skin, chapped skin, heat rash, chilblains, cracks, chapped skin, and acne, oily skin, razor burn, sunspots and freckles, soothing redness after sunburn or snowburn, tightening the skin, cleansing the skin, conditioning the skin, keeping the skin healthy, moisturizing the skin, protecting the skin, and preventing skin dryness. The topical skin preparation of this invention is preferably used as a cosmetic or quasi-drug, and is particularly preferred as a cosmetic or medicated cosmetic such as a lotion, cream, pack, or peeling agent. In particular, it is preferred when used as a pack because it provides a good feel and easily achieves a high level of skin condition improvement. [Examples]

[0117] The present invention will be described in more detail below with reference to examples, but the scope of the present invention is not limited to these examples. In each of the following examples and comparative examples, commercially available raw materials were used unless otherwise specified.

[0118] <Examples 1-10, Comparative Examples 1-3> Each component listed in Table 1 was blended and mixed in the composition shown in the table to produce the powdered topical skin preparations of Examples 1 to 10 and the powdered topical skin preparations of Comparative Examples 1 to 3. The values ​​in Table 1 below represent the mass percentage (mass%) of the topical skin preparation.

[0119] [Table 1]

[0120] The properties of the topical skin preparations of the above examples and comparative examples were evaluated according to the procedure described in [Evaluation of Examples 1-10 and Comparative Examples 1-3] below.

[0121] [Evaluation of Examples 1-10 and Comparative Examples 1-3] (1) Sensory evaluation Three healthy women in their 20s and 30s were randomly selected as subjects. The inner forearms of the subjects were washed with facial cleanser, and they rested quietly in the measurement room for 15 minutes. Next, a mixture of powdered topical skin preparation samples and water in a 1:3 (mass ratio) container was obtained to form a foamy pack cosmetic mixture. This mixture was applied to a 4cm x 4cm area on the inner forearm. Ten minutes after application, the mixture was removed from the forearm, and the forearm was washed with water. Subsequently, a questionnaire was administered to evaluate the user experience on four items: "ease of mixing," "ease of application," "resistance to dripping," and "ease of removal." In addition, four items regarding the condition of the skin after use were assessed on four items: "moisture," "skin elasticity," "skin brightness," and "skin redness." Each item was scored on a 7-point scale as shown in Table 2, and the average score of the three subjects was calculated after tabulation. The results are shown in Table 3. For "resistance to dripping," a higher score was given to the mixture that did not drip from the skin after application. Furthermore, for "moisture content," higher scores were given to those with higher skin moisture content, and for "skin redness," higher scores were given to those with more severe redness.

[0122] [Table 2]

[0123] [Table 3]

[0124] From the results in Table 3 above, it can be seen that the topical skin preparations of each example containing polysaccharides or their derivatives are superior to Comparative Examples 1-3 in terms of both usability, such as ease of mixing, ease of application, resistance to dripping, and ease of removal, and skin condition improvement effects, such as moisturizing effect, elasticity, brightness, and redness. Furthermore, it can be seen that Examples 2, 6-10, which contain two or more types of polysaccharides or their derivatives, show even greater improvements in both usability and skin condition. In addition, when water-soluble proteins are included, as in Examples 3, 6, 8, and 10, the effects of usability and skin condition improvement are further enhanced. It can also be seen that when extracts containing saponins, which are natural surfactants, are included instead of water-soluble proteins, as in Examples 4, 5, 7, and 9, these effects are equal to or greater than those of water-soluble proteins. Furthermore, it can be seen that high efficacy is obtained in Examples 3, 5-10, which contain GK2, salicylic acid, or arbutin. For example, as is clear from the comparison of Examples 4 and 5, the inclusion of GK2, a natural surfactant (and anti-inflammatory and whitening agent), not only enhances the effect of improving skin conditions such as redness, but also improves the feel of the topical skin preparation. From the above results, it can be seen that using two types of polysaccharides or their derivatives, as in Examples 2 to 5, or using water-soluble proteins and natural surfactants in combination, compared to Example 1 which uses one type of polysaccharide or its derivative, results in a better feel and skin condition improvement effect. Furthermore, it can be seen that using two or more types of polysaccharides or their derivatives in combination with water-soluble proteins or natural surfactants, as in Examples 6 to 10, further improves both the feel and the skin condition improvement effect.

[0125] (2) Measurement of skin condition Regarding the sensory evaluation described in (1) above, the L* value, stratum corneum moisture content, and elasticity were measured using the following measuring devices at the site on the inner forearm where the mixture was to be applied, before application of the mixture. After removing the mixture and washing with water, the L* value, stratum corneum moisture content, and elasticity were similarly measured at the site on the inner forearm where the mixture had been applied. The average values ​​for the three subjects were calculated from the obtained measurements. The average value after use of the topical skin preparation was divided by the average value before use, and the resulting value was defined as the rate of change. The rate of change of the L* value (whiteness) is shown in Figure 1, the rate of change of stratum corneum moisture content is shown in Figure 2, and the rate of change of elasticity is shown in Figure 3. In these figures, a higher rate of change indicates a higher evaluation.

[0126] • L* value: Measured using a colorimeter (Konica Minolta CR-400). • Stratum corneum moisture content: Measured using the SKICON-200EX skin surface stratum corneum moisture content measuring device (manufactured by IBS Corporation). This skin surface stratum corneum moisture content measuring device evaluates the moisture content of the stratum corneum by using the conductance (electrical conductivity, unit: μS) of the skin. • Elasticity: Measured using a skin viscoelasticity measuring device, Cutometer MPA580 (manufactured by Courage+Khazaka). These measurements were performed using the standard methods described in the instruction manual provided with the equipment.

[0127] The results in Figures 1 to 3 show that, in each example, the L* value, stratum corneum moisture content, and elasticity of the skin after use of the topical skin preparation were changed at a rate equivalent to or greater than that of each comparative example. In particular, it can be seen that the rate of change in the L* value, stratum corneum moisture content, and elasticity is increased by the inclusion of one or more factors selected from the following: the inclusion of two or more polysaccharides or their derivatives, the inclusion of water-soluble proteins, the inclusion of extracts containing saponins (a natural surfactant), the inclusion of glycyrrhizinate (a natural surfactant (inflammatory agent and whitening agent)), and the inclusion of other whitening agents or bactericides. For example, a comparison between Examples 1 and 2 shows that the inclusion of two or more polysaccharides or their derivatives improves the L* value, stratum corneum moisture content, and elasticity. A comparison between Examples 1 and 3 shows that the inclusion of water-soluble proteins and glycyrrhizinate improves the L* value, stratum corneum moisture content, and elasticity. A comparison between Examples 1 and 4 shows that the inclusion of extracts containing saponins improves the L* value, stratum corneum moisture content, and elasticity. Furthermore, a comparison of Examples 4 and 5 shows that the presence of glycyrrhizinate improves the moisture content of the stratum corneum. A comparison of Examples 6 and 8, and Examples 7 and 9, shows that the presence of a bactericide improves both the moisture content and elasticity of the stratum corneum. Finally, Example 10 shows that the presence of arbutin as a whitening agent improves the L* value.

[0128] (3) Evaluation of topical skin preparations 27 mL of water was placed in a bottle (225 mL) with a diameter of approximately 4.8 cm and a height of approximately 10.5 cm. 9 g of powdered topical skin preparation sample was added to this mixture and stirred 20 times over 10 seconds. The resulting mixture was evaluated for the following <amount of foaming> and <amount of carbon dioxide generated>.

[0129] <Fizzing amount> The volume of the mixture was measured 1 minute, 10 minutes, and 20 minutes after stirring, and the percentage increase in volume relative to the volume before stirring was calculated. The results are shown in Figure 4.

[0130] <Carbon dioxide generation amount> Carbon dioxide generated from the stirred mixture was collected by water displacement. The cumulative amount (mL) of collected carbon dioxide was measured at 3, 5, 7, 10, 15, 20, and 30 minutes after stirring. The results are shown in Figure 5.

[0131] The results in Figure 4 show that, even after time has passed since stirring, the volume of the mixture of the topical skin preparations in each example does not decrease significantly, and a certain amount of carbon dioxide is retained in the mixture. This effect is enhanced by one or more factors selected from the inclusion of two or more polysaccharides or their derivatives, the inclusion of water-soluble proteins, the inclusion of saponin-containing extracts, the inclusion of glycyrrhizinate, and the inclusion of other whitening or bactericidal agents, particularly the inclusion of water-soluble proteins or saponin-containing extracts and glycyrrhizinate. For example, a comparison of Examples 1 and 2 shows that the inclusion of two or more polysaccharides or their derivatives improves the carbon dioxide retention capacity of the resulting mixture. A comparison of Examples 1 and 3 shows that the inclusion of water-soluble proteins and glycyrrhizinate improves the carbon dioxide retention capacity of the resulting mixture. A comparison of Examples 1 and 4 shows that the inclusion of saponin-containing extracts improves the carbon dioxide retention capacity of the resulting mixture. A comparison of Examples 4 and 5 shows that the inclusion of glycyrrhizinate improves the carbon dioxide retention capacity of the resulting mixture. In contrast, in each comparative example, it is clear that bubbles in the mixture are not easily retained, and the volume of the mixture after stirring tends to decrease, meaning that the amount of carbon dioxide that can be retained in the mixture is small.

[0132] The results in Figure 5 show that in each example, carbon dioxide is generated relatively slowly for the first 5 minutes after stirring, and thereafter, although the gradient is gradual in some cases, the generation of carbon dioxide from the mixture continues without stopping. In particular, in Examples 2 to 10, which contain two or more polysaccharides or their derivatives, water-soluble proteins or saponins, glycyrrhizinates, or other whitening agents or disinfectants, the generation of carbon dioxide tends to continue for a longer period. For example, a comparison of Examples 1 and 3 shows that the amount of carbon dioxide generated increases when water-soluble proteins and glycyrrhizinates are included. A comparison of Examples 1 and 4 shows that the amount of carbon dioxide generated increases when saponin extracts are included. A comparison of Examples 4 and 5 shows that the amount of carbon dioxide generated increases when glycyrrhizinates are included. In contrast, in Comparative Examples 1 to 3, although the carbon dioxide generation rate was high up to 3 minutes after stirring, generation either stopped thereafter, or the amount of carbon dioxide generated was low.

[0133] <Examples 11-17> Each component was blended and mixed according to the proportions listed in Table 4 below to produce a powdered topical skin preparation. The values ​​in Table 4 represent the mass percentage (mass%) of the topical skin preparation.

[0134] [Table 4]

[0135] [Evaluation of Examples 11-17] <Sensory evaluation> Three healthy women in their 20s and 30s were randomly selected as subjects separate from those who evaluated Examples 1-10 and Comparative Examples 1-3 above. Otherwise, after using the powdered topical skin preparation samples in the same manner as in "(1) Sensory Evaluation" in the evaluation of Examples 1-10 and Comparative Examples 1-3 above, each subject was given a questionnaire regarding the following evaluation items. For each item, a score was assigned on a 7-point scale shown in Table 2 above, using Example 17 as the baseline (4.0 points). After tabulation, the average score of the three subjects was calculated. The results are shown in Table 5 below. Note that for "irritation," a higher score was given to those with a stronger tingling sensation. Similarly, for "skin stickiness," a higher score was given to those with less stickiness. The evaluation criteria consisted of 15 items in total: 8 items regarding use ("ease of application", "pleasantness of application", "appearance of the applied mixture", "resistance to dripping", "presence or absence of irritation (tingling)", "ease of spreading the mixture", "resistance to stickiness of the mixture", and "ease of removing the mixture") and 7 items regarding the condition of the skin after use ("skin's moisturizing effect", "skin's smoothness", "skin's suppleness", "skin's stickiness", "skin's firmness", "skin's tightening effect", and "skin's brightness").

[0136] [Table 5]

[0137] From the results in Table 5 above, it can be seen that in Examples 11 to 16, which further added each active ingredient (including a second water-soluble protein) to the composition of Example 17, which contains an acidic substance, a carbon dioxide generating substance, a polysaccharide or its derivative, and one water-soluble protein, both the feel of use and the effect of improving skin condition are improved. In particular, it can be seen that using the topical skin preparation of Example 11, in which gold leaf was added, improved the feel of use, such as the pleasantness during application and the appearance. It can also be seen that using the topical skin preparation of Example 12, in which pearl powder was added, improved skin brightness, etc. Furthermore, it can be seen that using the topical skin preparation of Example 13, in which collagen was added, particularly improved moisturizing and smoothness. Furthermore, it can be seen that using the topical skin preparation of Example 14, in which hydrolyzed collagen was added, improved ease of application, pleasantness, and appearance during use, as well as improved moisturizing and smoothness of the skin after use. Furthermore, it was found that using the topical skin preparation of Example 15, which contains placenta, improves the smoothness and suppleness of the skin after use. Using Example 16, which contains arbutin, improves the ease of application, pleasantness, and spreadability, and improves the smoothness and brightness of the skin after use.

[0138] [Evaluation of Examples 14-17] <Skin condition measurement> In the <Sensory Evaluation> of Examples 11-17 above, the amount of water evaporation (g / m²) at the planned application site on the inner forearm before application of the mixture was measured. 2 The amount of water evaporation (g / m²) at the application site on the inner forearm was measured using the following measuring device. After removing the mixture and washing with water, the amount of water evaporation (g / m²) at the application site on the inner forearm was also measured. 2 The same measurement was taken for ( / hr).

[0139] • Water evaporation rate (g / m³) 2 ( / hr): Measured using a Tewameter TM300 (Courage+Khazaka). This measurement was performed using the standard method described in the instruction manual included with the instrument. The average values ​​for the three subjects were calculated from the obtained measurements. The percentage change was calculated by dividing the average value before use by the average value after use of the topical skin agent. The percentage change in transepidermal water loss obtained is shown in Figure 6. A lower percentage change indicates a higher evaluation.

[0140] From the results in Figure 6 above, it can be seen that using the topical skin preparations of Example 14 (which adds hydrolyzed collagen to the composition of Example 17), Example 15 (which adds placenta), and Example 16 (which adds arbutin) further suppresses the amount of water evaporation from the skin. In particular, it can be seen that Example 15, which adds placenta, has a high inhibitory effect.

[0141] <Examples 18-20> Each component listed in Table 6 was blended and mixed according to the composition shown in the table to produce the powdered topical skin preparations of Examples 18-20. The values ​​in Table 6 represent the mass percentage (mass%) of the topical skin preparation.

[0142] [Table 6]

[0143] [Evaluation of Examples 18-20] <Sensory evaluation> Five healthy women in their 20s and 30s were randomly selected as subjects. For the rest of the study, the same sensory evaluation as in (1) Sensory Evaluation in [Evaluation of Examples 1-10 and Comparative Examples 1-3] was performed. However, the evaluation items were limited to four items representing the condition of the skin after use: "skin smoothness," "skin moistness," "skin hydration," and "skin softness." The subjects were also asked to rate their performance on a 7-point scale as shown in Table 2, using Example 20 as the baseline (4.0 points). After tabulation, the average of the five subjects' ratings was calculated. The results are shown in Table 7.

[0144] [Table 7]

[0145] [Evaluation of Examples 18 and 19] <Skin condition measurement> In the sensory evaluation of Examples 18-20 described above, the amount of stratum corneum moisture in the area on the inner forearm where the mixture was to be applied was measured using the measuring device described above before application of the mixture. Then, after removing the mixture and washing with water, the amount of stratum corneum moisture in the area on the inner forearm where the mixture was applied was measured in the same manner. From the obtained measurements, the average value for five subjects was calculated. The average value after use of the topical skin preparation was divided by the average value before use, and the resulting value was taken as the rate of change. These results are shown in Figure 7.

[0146] <Evaluation of topical skin preparations> Except for using 30 mL of water and 10 g of powdered topical skin preparation sample, the percentage increase in volume of the mixture after stirring was determined in the same manner as in (3) <Amount of foaming> in [Evaluation of Examples 1-10 and Comparative Examples 1-3]. The results are shown in Table 8 below.

[0147] [Table 8]

[0148] <Example 21> Each component listed in Table 9 was blended and mixed in the composition shown in the table to produce the powdered topical skin preparation of Example 21. The values ​​in Table 9 represent the mass percentage (mass%) of the topical skin preparation.

[0149] [Table 9]

[0150] <Comparative Example 4> Each component listed in Table 10 was blended and mixed in the composition shown in the table to produce a carbonate-containing powder and an acid-containing liquid, respectively. The values ​​in Table 10 are in parts by mass. The viscosity of the obtained acid-containing liquid was measured at 25°C using a viscometer (Brookfield RVT type) and was found to be 16.9 mPa·s.

[0151] [Table 10]

[0152] <Comparative Example 5> Each component listed in Table 11 was blended and mixed in the composition shown in the table to produce an acid-containing powder and a carbonate-containing viscous composition, respectively. The values ​​in Table 11 are in parts by mass. The viscosity of the obtained viscous composition was measured at 25°C using the above-mentioned viscometer and was found to be 549,600 mPa·s.

[0153] [Table 11]

[0154] [Evaluation of Example 21 and Comparative Examples 4 and 5] (1) Sensory evaluation Four healthy women in their 20s and 30s were randomly selected as subjects. For all other subjects, the same sensory evaluation as in (1) Sensory Evaluation in [Evaluation of Examples 1-10 and Comparative Examples 1-3] was performed. However, in Example 21, a powdered topical skin preparation was mixed with water in a mass ratio of 1:2.7. In Comparative Example 4, a mixture was obtained by mixing a powder containing carbonate with a liquid containing acid in a mass ratio of 1:3. In Comparative Example 5, a mixture was obtained by mixing a powder containing acid with a viscous composition containing carbonate in a mass ratio of 1:3.68. The evaluation items were "skin elasticity" and "skin redness," representing the condition of the skin after use of the topical skin preparation. The 7-point scale shown in Table 2 was used, with Comparative Example 4 as the baseline (4.0 points). After tabulation, the average of the evaluation scores from the four subjects was calculated. The results are shown in Table 12. Furthermore, when the viscosity of the water used in Example 21 at 25°C was measured with the above viscometer, it showed a value below the lower limit of the viscometer (10 mPa·s).

[0155] [Table 12]

[0156] (2) Measurement of skin condition In the sensory evaluation described in (1) above, the L* value at the site on the inner forearm where the mixture was to be applied was measured using the measuring device described above before application. Then the mixture was applied, removed, and washed with water. At 15, 60, and 120 minutes after the completion of removal, the L* value of the area on the inner forearm where the mixture was applied was measured using the above measuring device. The average value for the four subjects was calculated from the obtained measurements. The change value was obtained by subtracting the average value before use from the average value after use of the topical skin agent. The obtained changes in L* value (whiteness) are shown in Table 13. In this table, a higher change value indicates a higher evaluation.

[0157] [Table 13]

[0158] As is clear from the descriptions in Tables 12 and 13, Example 21, in which a topical skin preparation containing an acidic substance, a carbon dioxide generating substance, and a polysaccharide or its derivative was mixed with a water-containing substance, showed a higher effect in improving the condition of the skin after use compared to Comparative Example 4, in which a powder containing carbonate was mixed with a liquid containing acid, and Comparative Example 5, in which a powder containing acid was mixed with a viscous composition containing carbonate.

[0159] <Examples 22-23> Each component was blended and mixed according to the proportions listed in Table 14 below to produce a powdered topical skin preparation. The values ​​in Table 14 represent the mass percentage (mass%) of the topical skin preparation.

[0160] [Table 14]

[0161] [Evaluation of Examples 22-23] <Evaluation of storage stability> The powdered topical skin preparations obtained in Examples 22-23 were sealed in 9g portions in aluminum film bags laminated with polyethylene terephthalate on the inside. They were stored at 50°C or 60°C for 2 months, and the presence or absence of carbon dioxide generation was observed during storage, using the presence or absence of bag inflation as an indicator. The results are shown in Table 15. In the table, "None" indicates that no carbon dioxide generation was observed during the storage period (2 months).

[0162] [Table 15]

[0163] As is clear from Table 15, in Examples 22 and 23, which contained 10% by mass or more of potato starch, no carbon dioxide gas was generated even after storage at 60°C for two months, confirming good storage stability.

[0164] <Example 24> Each component was blended and mixed according to the proportions listed in Table 16 below to produce a powdered topical skin preparation. The values ​​in Table 16 represent the mass percentage (mass%) of the topical skin preparation.

[0165] [Table 16]

[0166] The properties of the topical skin preparations of the above examples and comparative examples were evaluated according to the procedure of [Example 24] below.

[0167] [Evaluation of Example 24] <Anti-wrinkle function evaluation> Sixteen adult women with crow's feet were selected as subjects. A mixture of powdered topical skin preparation and water in a 1:3 (mass ratio) container was used to create a foamy pack cosmetic. This mixture was applied to a designated half of the face, centering on either the left or right crow's foot. Ten minutes after application, the mixture was removed and rinsed with water or lukewarm water. The subjects performed this once a day for four weeks. Wrinkle evaluation involved taking replicas of the crow's feet on both sides of the subjects' faces (with and without the mixture applied) and performing image analysis on the replicas. Replicas were taken using a replica agent (SILFLO) over a 4cm x 4cm area lateral to the outer corner of the eye. The obtained replicas were analyzed over a 10mm x 10mm area, with a reference point approximately 5mm away from the outer corner of the eye. The analysis was performed using a reflective replica analysis system (ASA-03RXD) and 3D skin analysis software. The results of the maximum wrinkle depth, which represent the evaluation of wrinkles, are shown in Table 17. A positive change indicates that wrinkles have become deeper compared to before use, while a negative change indicates that wrinkles have become shallower compared to before use.

[0168] [Table 17]

[0169] Table 17 shows that using the topical skin preparation of the present invention resulted in a shallower maximum depth of the maximum wrinkle at the corner of the eye compared to when it was not used. These results indicate that the use of the effervescent topical skin preparation of the present invention has the effect of making wrinkles less noticeable.

[0170] [Examples of prescriptions for single-dose topical skin preparations] The following shows specific formulation examples of the one-dose topical skin preparation of the present invention.

[0171] <Example 25> Each component was blended according to the proportions shown in Table 18 to form a single-component topical skin preparation in powder form. This single-component topical skin preparation powder was placed in a container, and water was added in a mass ratio of 1 part powder to 3 parts water, which was then stirred to obtain a foamy pack cosmetic.

[0172] [Table 18]

[0173] <Example 26> Each component was blended according to the proportions shown in Table 19 to form a single-component topical skin preparation in powder form. This single-component topical skin preparation powder was placed in a container, and water was added in a mass ratio of 5 parts to 1 part powder and stirred to obtain a foamy pack cosmetic.

[0174] [Table 19]

[0175] <Example 27> Each component was blended according to the proportions shown in Table 20 to create a single-component topical skin preparation in powder form. This single-component topical skin preparation powder was placed in a container, and water was added in a mass ratio of 1:10 to 1 part powder and stirred to obtain a foamy pack cosmetic.

[0176] [Table 20]

[0177] <Example 28> Each component was blended according to the proportions shown in Table 21 to create a single-component topical skin preparation in powder form. This single-component topical skin preparation powder was placed in a container, and water was added in a mass ratio of 1 part powder to 3 parts water, which was then stirred to obtain a foamy pack cosmetic.

[0178] [Table 21]

[0179] <Example 29> Each component was blended according to the proportions shown in Table 22 to form a single-component topical skin preparation in powder form. This single-component topical skin preparation powder was placed in a container, and water was added in a mass ratio of 4 parts to 1 part powder and stirred to obtain a foamy pack cosmetic.

[0180] [Table 22]

[0181] <Example 30> Each component was blended according to the proportions shown in Table 23 to form a single-component topical skin preparation in powder form. This single-component topical skin preparation powder was placed in a container, and water was added in a mass ratio of 1:10 to 1 part powder and stirred to obtain a foamy pack cosmetic.

[0182] [Table 23]

[0183] <Example 31> Each component was blended according to the proportions shown in Table 24 to form a single-component topical skin preparation in powder form. This single-component topical skin preparation powder was placed in a container, and water was added in a mass ratio of 4 parts water to 1 part powder and stirred to obtain a foamy pack cosmetic.

[0184] [Table 24]

[0185] <Example 32> Each component was blended according to the proportions shown in Table 25 to form a single-component topical skin preparation in powder form. This single-component topical skin preparation powder was placed in a container, and water was added in a mass ratio of 4 parts water to 1 part powder and stirred to obtain a foamy pack cosmetic.

[0186] [Table 25]

[0187] <Examples 2-1 to 2-28, Comparative Examples 2-1 and 2-2> Each component listed in Table A below was blended and mixed in the composition shown in the table to produce the powdered topical skin preparations of Examples 2-1 to 2-28, and the powdered topical skin preparations of Comparative Examples 2-1 and 2-2. The values ​​in Table A below represent the mass percentage (mass%) of the topical skin preparation. For the carboxymethylcellulose listed in Table A below, sodium carboxymethylcellulose was used. For the acrylic acid / alkyl methacrylate copolymer listed in Table A below, (acrylates / alkyl acrylate (C10-30)) crosspolymer was used. In Table A, "Pattern" indicates whether the preparation falls under (1) to (3) above, which relate to a combination of two or more polysaccharides or their derivatives, or (4) above, which relates to a combination of a polysaccharide or its derivative with an inorganic or organic thickening compound. This classification is also shown in Table C below.

[0188] [Table A]

[0189] The characteristics of the topical skin preparations for Examples 2-1 to 2-28 and Comparative Examples 2-1 and 2-2, based on the formulations in Table A above, were evaluated using the same method as the sensory evaluation in (1) of the evaluation of Examples 1 to 10 and Comparative Examples 1 to 3 described above. However, the questionnaire items were as shown in (1) to (19) of Table C below. The results are shown in Table C below. The evaluation criteria were based on the 7-level absolute evaluation described in Table B below. In Table C, "(4) Fineness of bubbles" was rated higher the finer the bubbles were. "(10) Carbonation sensation (fizzing sensation)" was rated higher the more fizzing sensation there was. "(11) Duration of carbonation sensation (fizzing sensation)" was rated higher the longer the carbonation sensation lasted. "(12) Skin tightening sensation" was rated higher the more tightening sensation there was.

[0190] [Table B]

[0191] [Table C]

[0192] In Table C, CMC is an abbreviation for carboxymethylcellulose sodium, tamarind is an abbreviation for tamarind gum, HPMC is an abbreviation for hydroxypropylmethylcellulose, HEC is an abbreviation for hydroxyethylcellulose, graft starch is an abbreviation for sodium acrylate graft starch, acrylic acid is an abbreviation for acrylic acid / alkyl methacrylate copolymer, and PVP is an abbreviation for polyvinylpyrrolidone.

[0193] As is clear from the results in Table C, the topical skin preparations of Examples 2-1 to 2-28, which fall under any of (1) to (4), were at least equal to or better than the topical skin preparations of Comparative Examples 2-1 and 2-2, which employ a combination of conventional polysaccharides or their derivatives, in terms of ease of mixing, ease of dissolution, ease of removal, and evaluation of skin brightness. They were also superior in all aspects, including foam fineness, uniformity, ease of application, foam elasticity, foam retention, carbonation sensation, duration of carbonation sensation, skin moisturizing effect, skin elasticity, skin redness, skin smoothness, skin suppleness, and skin tightening effect. Therefore, it is clear that the topical skin preparations of the present invention that fall under any of (1) to (4) exhibit a remarkable effect of "good usability and improvement of skin condition."

[0194] The L* values, stratum corneum moisture content (μS), and elasticity of the topical skin preparations for Examples 2-1 to 2-28, Comparative Examples 2-1 and 2-2, based on the formulations in Table A above, were measured before and after use using the same method as described in "(2) Measurement of Skin Condition" in the evaluation of Examples 1 to 10 and Comparative Examples 1 to 3 above. For the obtained L* values, stratum corneum moisture content, and elasticity, the ratio of the measured values ​​after use to the measured values ​​before use of the topical skin preparation was calculated and expressed as the rate of change. The results are shown in Figures 8 to 10. In addition, the transepidermal water loss (g / m³) of the topical skin preparations for Examples 2-1 to 2-28, Comparative Examples 2-1 and 2-2, based on the formulations in Table A above, was measured before and after use. 2 The amount of water evaporation per hour ( / hr) was measured using the same method as described in "<Measurement of Skin Condition>" of the above-mentioned [Evaluation of Examples 14-17]. For the obtained amount of water evaporation, the ratio of the measured value after use to the measured value before use of the topical skin preparation was calculated and expressed as the rate of change. The results are shown in Figure 11.

[0195] As is clear from the results in Figures 8 to 10, the rate of change in elasticity of the topical skin preparations of Examples 2-1 to 2-28, which fall under any of (1) to (4), was equal to or better than that of the topical skin preparation of Comparative Example 2-2, and was superior to that of Comparative Example 2-1. Furthermore, the rate of change in L* value and stratum corneum moisture content of the topical skin preparations of Examples 2-1 to 2-28 were superior to both Comparative Examples 2-1 and 2-2. Therefore, it is clear that the effect of "improving the condition of the skin" associated with the topical skin preparation of the present invention, which falls under any of (1) to (4), is remarkable.

Claims

[Claim 1] A foaming topical skin preparation comprising at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, further comprising, At least two polysaccharides or their derivatives, It contains an anti-inflammatory agent, The polysaccharide or its derivative comprises at least one cellulose derivative and at least one selected from carrageenan, xanthan gum, guar gum, and tamarind gum. The anti-inflammatory agent is at least one selected from allantoin, stearyl glycyrrhetinate, licorice extract, and aloe extract. A foaming topical skin preparation that is mixed with water when used as described above.

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