Collagen production promoters and topical skin preparations containing them

Kaempferol glycosides in topical skin preparations enhance collagen production, addressing skin resilience and wrinkle issues by increasing collagen density and fiber density, thus improving skin firmness and elasticity.

JP7888125B2Active Publication Date: 2026-07-13ICHIMARU PHARCOS CO LTD
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Patent Information

Application Number
JP2022138944
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2021-09-24
Filing Date
2022-09-01
Publication Date
2026-07-13
Estimated Expiration
2042-03-11

AI Technical Summary

Technical Problem

Existing skincare methods fail to effectively maintain skin softness and resilience due to aging and external factors, leading to issues like wrinkles and loss of collagen and elastin.

Method used

A topical skin preparation containing kaempferol glycosides or their derivatives, which promote collagen production and enhance skin firmness, using compounds like kaempferol-3-(6''-rhamnosyl-2''-glucosyl-glucoside) and its organic acid esters, applied in formulations such as lotions and creams.

Benefits of technology

The preparation maintains skin softness and resilience by increasing collagen density, reducing wrinkle depth and width, and improving dermal collagen fiber density, as demonstrated in human trials.

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Abstract

For example, to find agents containing active ingredients derived from natural products that maintain the softness of the skin and give it resilience (firmness). The present invention provides a compound of the following formula (I): JPEG2022168011000017.jpg69170 (in the formula, R 1 represents a hydrogen atom or a rhamnosyl group, and R 2 represents a glucosyl group or a rhamnosyl group.) An agent for promoting collagen production, comprising a compound represented by the formula (I), its organic acid ester, or a salt thereof.
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Citation Information

Patent Citations

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  • Fibroblast growth promoting agent, skin cosmetic and food and drink for beauty

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    JP2007223918A

  • Skin care external preparation having collagen production promotion action obtained from daisy inflorescence

    JP2011213699A

  • Skin external preparation

    JP2020189832A