Method for producing 225Ac solution
The two-step solid-phase extraction process using compounds (A) and (B) addresses low purity and solvent inefficiencies in producing 225Ac, resulting in high-purity solutions suitable for radiopharmaceuticals.
JP7888459B2Active Publication Date: 2026-07-13NIHON MEDI PHYSICS CO LTD
Patent Information
- Application Number
- JP2022536364
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2020-07-17
- Filing Date
- 2021-07-13
- Publication Date
- 2026-07-13
- Estimated Expiration
- 2041-07-13
AI Technical Summary
Technical Problem
Conventional methods for producing 225Ac solutions suffer from low purity due to the presence of significant amounts of 226Ra, require large amounts of solvent, and are inefficient in separating and purifying 225Ac, leading to challenges in solvent usage and Ra recovery.
Method used
A method involving two-step solid-phase extraction using specific compounds represented by formulas (A) and (B) to selectively retain and elute 225Ac ions, reducing solvent use while achieving high purity.
Benefits of technology
This method enables the production of high-purity 225Ac solutions with reduced solvent consumption, suitable for applications in radiopharmaceuticals by minimizing contamination from Ra and its daughter nuclides.
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Abstract
This method for producing a 225Ac solution comprises steps (I)-(III). In step (I), a solution (1) containing 226Ra and 225Ac is passed through a solid-phase extractant (a) containing a compound represented by formula (A), and 225Ac is held in the solid-phase extractant (a). In step (II), a liquid, which contains an eluate (2) obtained by eluting the held 225Ac from the solid-phase extractant (a), is passed through a solid-phase extractant (b) containing a compound represented by formula (B), and 225Ac is held in the solid-phase extractant (b). In step (III), the held 225Ac is eluted from the solid-phase extractant (b) to obtain a 225Ac solution. (A) [m and n are each independently 0 or 1, and R1-R4 are each independently a C8-C12 alkyl group.] (B) [R5-R6 are each independently a C8 alkyl group or a C8 alkoxy group.]
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Citation Information
Patent Citations
Methods for Purifying 225ac from Irradiated 226ra Targets
JP2009527731A
Separation of protactinum, actinium, and other radionuclides from proton irradiated thorium target
US20150292061A1
METHOD FOR PURIFYING 226Ra-CONTAINING SOLUTION, METHOD FOR PRODUCING 226Ra TARGET AND METHOD FOR PRODUCING 225Ac
WO2021002275A1