FMS様チロシンキナーゼ3リガンド(FLT3L)ベースキメラタンパク質

Abstract

To provide FMS-like tyrosine kinase 3L (FLT3L) fused to human cytokines, which is use in, e.g., cancer treatment.SOLUTION: The present invention provides a chimeric protein comprising a targeting moiety which comprises a single copy of FMS-like tyrosine kinase 3 ligand (FLT3L), or a portion thereof. In various embodiments, the targeting moiety functionally modulates an antigen or receptor of interest. In some embodiments, the targeting moiety binds but does not functionally modulate the antigen or receptor of interest. In some embodiments, the targeting moiety comprises a single copy of the extracellular domain of FLT3L, or respective portions thereof.SELECTED DRAWING: Figure 1

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