チロシンキナーゼ阻害剤の小児用製剤

Abstract

A pediatric dosage form for administering an ultra-low dose of an active pharmaceutical ingredient having a plurality of pellets, each consisting essentially of a coating of a tyrosine kinase inhibitor on a nonpareil seed. The tyrosine kinase inhibitor-coated nonpareils are coated on their surfaces with a coating consisting essentially of hydroxypropyl methylcellulose. The active coated beads of the invention allow for administration to human subjects in mg / kg increments. A total of such pellets contained within a capsule form a single dosage unit of the ultra-low dose of the tyrosine kinase inhibitor. TIFF2023520021000024.tif74140

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