Retinol preparations (II)

Abstract

The present invention relates to novel formulations containing high amounts of retinol in the presence of mixed tocopherols in specific solvents.

Description

Detailed description of the invention

[0001] The present invention relates to a novel formulation containing a large amount of retinol in a specific solvent in the presence of mixed tocopherols.

[0002] Retinol is given by the following formula [ka] It is a compound of, This compound possesses properties that make it extremely interesting for applications in various fields.

[0003] Following its applications in food, animal feed, and pharmaceuticals, retinol is also highly useful in personal care applications.

[0004] When used in the field of personal care, retinol is primarily used for skin maintenance.

[0005] Topical application of retinol offers the following benefits: • It not only prevents wrinkles by minimizing them, but also smooths out existing fine lines and wrinkles. By removing dead skin cells at the cellular level, it brightens dull skin, resulting in brighter, smoother, and more youthful-looking skin. • Regulates oily skin and minimizes breakouts. • Lightens dark age spots, sunspots, and hyperpigmentation, resulting in an even complexion over time.

[0006] For the manufacture of end-market products (such as creams), it is necessary to provide formulations containing retinol that can be incorporated into the end-market product.

[0007] It is highly advantageous that the formulation used to manufacture the final market product contains a large amount of retinol, which means that there are not many solvents and other components. This means that the concentrations of such solvents and other components can be kept low in the final market product, and the formulation of the present invention can be used in a wide range of applications.

[0008] Furthermore, such formulations containing a large amount of retinol must be stable so that the retinol content does not decrease during storage.

[0009] Furthermore, since antioxidants such as butylated hydroxytoluene (BHT) or butylated hydroxyanisole (BHA) are banned in various countries for specific applications, it was also a goal to avoid using these antioxidants.

[0010] We found that by selecting a specific solvent (for retinol) and a mixed tocopherol (as an antioxidant), it is possible to produce a high-concentration and stable retinol formulation.

[0011] The selection of a specific solvent is extremely important for the formulation according to the present invention. The solvent used in the formulation is of formula (I) [ka] [In the formula, w, x, y, and z are integers that are independent of each other and whose sum equals 20, and also, R is a chain-like or branched C 10 ~C 18 - Alkyl portion or chain or branched C 10 ~C 18 -This is the alkylene portion. It is a compound of [the compound].

[0012] The present invention Based on the total weight of the formulation, 40-75% by weight (wt%) of retinol, Based on the total weight of the formulation, at least one solvent in an amount of 20-55% by weight, 0.1 to 5% by weight of mixed tocopherols based on the total weight of the formulation and a formulation (F) comprising at least one solvent is a compound of formula (I)

Chemical formula

[0013] The present invention relates to 40 to 75% by weight of retinol based on the total weight of the formulation, 20 to 55% by weight of at least one solvent based on the total weight of the formulation, 0.1 to 5% by weight of mixed tocopherols based on the total weight of the formulation and a formulation (F1) consisting of at least one solvent is a compound of formula (I)

Chemical formula

[0014] The present invention relates to Based on the total weight of the formulation, 40-75% by weight of retinol, Based on the total weight of the formulation, at least one solvent in an amount of 20-55% by weight, Based on the total weight of the preparation, 0.1 to 5% by weight of mixed tocopherols and A substantially derived formulation (F2), At least one solvent is given by formula (I) [ka] [In the formula, w, x, y, and z are integers that are independent of each other and whose sum equals 20, and also, R is a chain-like or branched C 10 ~C 18 - Alkyl portion or chain or branched C 10 ~C 18 -This is the alkylene portion. This relates to a formulation (F2) which is a compound of [the compound].

[0015] It is clear that the percentages of all formulations disclosed in this patent application always add up to 100.

[0016] The formulation according to the present invention is not an emulsion. The formulation according to the present invention is an oil formulation. This means that the water content of the formulation according to the present invention can be kept as low as possible. Water is not intentionally added to the formulation. However, the components of the formulation according to the present invention may contain trace amounts of water.

[0017] The retinol oil formulation according to the present invention, which uses the solvent of the present invention as a solubilizer, ensures the easy and flexible use of such solution in further applications, while emulsification pathways (which have more components) of such active ingredients can have detrimental effects on the final application.

[0018] The present invention relates to a formulation (F') which is a formulation (F), wherein the formulation (F') contains less than 2% by weight of water based on the total weight of the formulation.

[0019] The present invention relates to a formulation (F'') which is a formulation (F), wherein the formulation contains less than 1% by weight of water based on the total weight of the formulation.

[0020] The present invention relates to a formulation (F''') which is a formulation (F), wherein the formulation contains less than 0.5% by weight of water based on the total weight of the formulation.

[0021] Retinol may be obtained from natural sources or chemically synthesized. Mixtures of retinol supplied in this way may also be used. Trace amounts of other components (impurities) may be present depending on the manufacturing or extraction process. However, these impurities are usually present in amounts of less than 1% by weight (based on the weight of retinol).

[0022] The amount of retinol in the formulation according to the present invention is 40 to 75% by weight, based on the total weight of the formulation.

[0023] The formulation according to the present invention always contains, based on the total weight of the formulation, preferably 40-70% by weight, more preferably 42-70% by weight, 42-65% by weight, 45-65% by weight, 45-60% by weight, or 45-55% by weight of retinol.

[0024] Accordingly, the present invention relates to a formulation (F3) which is formulation (F), (F'), (F''), (F'''), (F1) or (F2), and which contains 40 to 70% by weight of retinol based on the total weight of the formulation.

[0025] Accordingly, the present invention relates to a formulation (F3') which is formulation (F), (F'), (F''), (F'''), (F1) or (F2), and which contains 42 to 70% by weight of retinol based on the total weight of the formulation.

[0026] Accordingly, the present invention relates to a formulation (F3'') which is formulation (F), (F'), (F''), (F'''), (F1) or (F2), and which contains 42 to 65% by weight of retinol based on the total weight of the formulation.

[0027] Accordingly, the present invention relates to a formulation (F3''') which is formulation (F), (F'), (F''), (F'''), (F1) or (F2), and which contains 45 to 65% by weight of retinol based on the total weight of the formulation.

[0028] Accordingly, the present invention relates to a formulation (F3'''') which is formulation (F), (F'), (F''), (F'''), (F1) or (F2), and which always contains 45 to 60% by weight of retinol based on the total weight of the formulation.

[0029] Accordingly, the present invention relates to a formulation (F3'''''') which is formulation (F), (F'), (F''), (F'''), (F1) or (F2), and which contains 45 to 55% by weight of retinol based on the total weight of the formulation.

[0030] As mentioned above, the choice of solvent is extremely important for the stability of the formulation according to the present invention.

[0031] At least one solvent of formula (I) is used in the formulation according to the present invention.

[0032] A preferred solvent is formula (I) [In the formula, w, x, y, and z are integers that are independent of each other and whose sum equals 20, and, R is a chain of C 11 -alkyl, chain-like C 17 - Alkyl moiety or chain-like C 17 -The compound is an alkylene moiety (preferably of the formula -(CH2)-CH=CH-(CH2)7CH3).

[0033] Particularly preferred are the following solvents (either by themselves or as a mixture): polysorbate 20, polysorbate 60, and polysorbate 80.

[0034] Most preferably, it is polysorbate 20.

[0035] Such suitable solvents are commercially available from various manufacturers (Oxiteno, Croda, Seppic, etc.) under trade names such as Montanox, Alkest TW, and Tween.

[0036] Accordingly, the present invention relates to a formulation (F4) which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3''''), (F3''''), or (F3''''''), wherein at least one solvent is of formula (I) [In the formula, w, x, y, and z are integers that are independent of each other and whose sum equals 20, and, R is a chain of C 11 -alkyl, chain-like C 17 - Alkyl moiety or chain-like C 17 This relates to a formulation (F4) which is a compound having an alkylene moiety (preferably of the formula -(CH2)-CH=CH-(CH2)7CH3).

[0037] Accordingly, the present invention relates to a formulation (F4') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), or (F3''''''), wherein at least one solvent is selected from the group consisting of polysorbate 20, polysorbate 60, and polysorbate 80.

[0038] Accordingly, the present invention relates to a formulation (F4'') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), or (F3''''''), wherein the solvent is polysorbate 20.

[0039] The formulation according to the present invention contains at least one solvent in an amount of 20 to 55% by weight, based on the total weight of the formulation.

[0040] It is always preferable to use at least one solvent in amounts of 25-55% by weight, 28-55% by weight, or 35-55% by weight, based on the total weight of the formulation.

[0041] Accordingly, the present invention relates to a formulation (F5) which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F3''''''), (F4), (F4'), or (F4''), and which contains at least one solvent in an amount of 25 to 55% by weight based on the total weight of the formulation.

[0042] Accordingly, the present invention relates to a formulation (F5') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F3''''''), (F4), (F4'), or (F4''), and which contains at least one solvent in an amount of 28 to 55% by weight based on the total weight of the formulation.

[0043] Accordingly, the present invention relates to a formulation (F5'') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F3''''''), (F4), (F4'), or (F4''), and which contains at least one solvent in an amount of 35 to 55% by weight based on the total weight of the formulation.

[0044] The formulation according to the present invention contains mixed tocopherols (0.1 to 5% by weight based on the total weight of the formulation) as an antioxidant.

[0045] Mixed tocopherols are the following four compounds α-tocopherol and β-tocopherol and, γ-tocopherol and, It is a mixture with δ-tocopherol.

[0046] Typically, mixed tocopherols are, Based on the total weight of the mixed tocopherols, up to a maximum of 20% by weight of α-tocopherol, Based on the total weight of the mixed tocopherols, up to a maximum of 5% by weight of β-tocopherol, Based on the total weight of the mixed tocopherols, up to a maximum of 75% by weight of γ-tocopherol, Based on the total weight of the mixed tocopherols, up to a maximum of 35% by weight of δ-tocopherols and Includes.

[0047] Preferred mixed tocopherols are, Based on the total weight of the mixed tocopherols, 10-20% by weight of α-tocopherol and Based on the total weight of the mixed tocopherols, 1-5% by weight of β-tocopherol and Based on the total weight of the mixed tocopherols, 50-75% by weight of γ-tocopherol and Based on the total weight of the mixed tocopherols, 15-35% by weight of δ-tocopherol and Includes.

[0048] Therefore, the present invention relates to a formulation (F6) which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), or (F5''), wherein the mixed tocopherol is Based on the total weight of the mixed tocopherols, up to a maximum of 20% by weight of α-tocopherol, Based on the total weight of the mixed tocopherols, up to a maximum of 5% by weight of β-tocopherol, Based on the total weight of the mixed tocopherols, up to a maximum of 75% by weight of γ-tocopherol, Based on the total weight of the mixed tocopherols, up to a maximum of 35% by weight of δ-tocopherols and This relates to a formulation containing (F6).

[0049] Therefore, the present invention relates to a formulation (F6') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), or (F5''), wherein the mixed tocopherol is Based on the total weight of the mixed tocopherols, 10-20% by weight of α-tocopherol and Based on the total weight of the mixed tocopherols, 1-5% by weight of β-tocopherol and Based on the total weight of the mixed tocopherols, 50-75% by weight of γ-tocopherol and Based on the total weight of the mixed tocopherols, 15-35% by weight of δ-tocopherol and This relates to a formulation containing (F6').

[0050] Mixed tocopherols are commercially available from various manufacturers (such as BASF, DuPont, Merck, and DSM).

[0051] The formulation according to the present invention further contains no antioxidants other than mixed tocopherols (such as BHA and BHT).

[0052] Accordingly, the present invention relates to a formulation (F7) which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), or (F6'), wherein the formulation (F7) further contains no antioxidants (other than mixed tocopherols).

[0053] Accordingly, the present invention relates to a formulation (F7') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), or (F6'), wherein the formulation (F7') does not (substantially) contain either BHA or BHT.

[0054] The formulation according to the present invention contains 0.1 to 5% by weight of mixed tocopherols based on the total weight of the present invention.

[0055] Preferably, the formulation according to the present invention always contains mixed tocopherols in the following amounts based on the total weight of the formulation: 0.2-4.5% by weight, 0.2-4% by weight, 0.3-4% by weight, 0.4-3.5% by weight, 0.4-3% by weight, 0.4-2.5% by weight, and 0.4-2% by weight.

[0056] Accordingly, the present invention relates to a formulation (F8) which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), or (F7'), and which contains 0.2 to 4.5% by weight of mixed tocopherols based on the total weight of the formulation.

[0057] Accordingly, the present invention relates to a formulation (F8') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), or (F7'), and which contains 0.2 to 4% by weight of mixed tocopherols based on the total weight of the formulation.

[0058] Accordingly, the present invention relates to a formulation (F8'') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), or (F7'), and which contains 0.3 to 4% by weight of mixed tocopherols based on the total weight of the formulation.

[0059] Accordingly, the present invention relates to a formulation (F8''') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), or (F7'), and which contains 0.4 to 3.5% by weight of mixed tocopherols based on the total weight of the formulation (F8''').

[0060] Accordingly, the present invention relates to a formulation (F8'''') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3''''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), or (F7'), and which contains 0.4 to 3% by weight of mixed tocopherols based on the total weight of the formulation (F8'''').

[0061] Accordingly, the present invention relates to a formulation (F8'''''') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3''''), (F3''''), (F3''''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), or (F7'), and which contains 0.4 to 2.5% by weight of mixed tocopherols based on the total weight of the formulation (F8'''''').

[0062] Accordingly, the present invention relates to a formulation (F8'''''') which is formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3''''), (F3''''), (F3''''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), or (F7'), and which contains 0.4 to 2% by weight of mixed tocopherols based on the total weight of the formulation (F8'''''').

[0063] The formulations according to the present invention are manufactured using generally known methods and commonly used equipment.

[0064] A general method for manufacturing the formulation according to the present invention is as follows: Mix retinol and mixed tocopherols at a high temperature (usually in the range of 40-65°C). Heat at least one solvent to a temperature similar to that of the retinol / mixed tocopherol mixture (typically in the temperature range of 40-65°C). Add at least one solvent to the retinol / mixed tocopherol mixture at a high temperature (typically in the range of 40-65°C) (or vice versa), and mix it at this temperature. • Slowly cool the mixture.

[0065] Therefore, the present invention also relates to a method for producing any of the formulations (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), (F7'), (F8), (F8'), (F8''), (F8'''), (F8''''), (F8'''''), (F8'''''), or (F8''''''), the following • A step of mixing retinol and mixed tocopherols at a high temperature (usually in the temperature range of 40-65°C). The step of heating at least one solvent to a temperature similar to that of the retinol / mixed tocopherol mixture (typically in the temperature range of 40-65°C), The step of adding at least one solvent to the retinol / mixed tocopherol mixture at a high temperature (usually in the temperature range of 40-65°C) (or vice versa), and mixing it at this temperature. • A step of slowly cooling the mixture, Regarding methods including

[0066] Alternatively, retinol can be mixed first in a solvent (usually in the temperature range of 40-65°C), then mixed with the mixed tocopherols (also usually in the temperature range of 40-65°C), and the mixture can be slowly cooled.

[0067] Alternatively, the mixed tocopherols can be first mixed in a solvent (usually in the temperature range of 40-65°C), then mixed with retinol (also usually in the temperature range of 40-65°C), and the mixture can be slowly cooled.

[0068] The formulation according to the present invention can be used in a variety of applications, including food, animal feed, pharmaceuticals, and personal care.

[0069] The formulation according to the present invention is preferably used to be incorporated into personal care products (such as creams and lotions).

[0070] Accordingly, the present invention also relates to the use of at least one formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), (F7'), (F8), (F8'), (F8''), (F8'''), (F8''''), (F8''''), (F8'''''), or (F8'''''') in food, feed, pharmaceutical and personal care products.

[0071] Therefore, the present invention also relates to the use of at least one formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), (F7'), (F8), (F8'), (F8''), (F8'''), (F8''''), (F8''''), (F8'''''), or (F8'''''') in personal care products (creams, lotions, etc.).

[0072] Furthermore, the present invention also relates to foods, feeds, pharmaceuticals and personal care and personal care products comprising at least one formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), (F7'), (F8), (F8'), (F8''), (F8'''), (F8''''), (F8'''''), (F8''''''), or (F8'''''').

[0073] Furthermore, the present invention also relates to personal care products (such as creams and lotions) comprising at least one formulation (F), (F1), (F2), (F3), (F3'), (F3''), (F3'''), (F3''''), (F3''''), (F4), (F4'), (F4''), (F5), (F5'), (F5''), (F6), (F6'), (F7), (F7'), (F8), (F8'), (F8''), (F8'''), (F8''''), (F8'''''), (F8'''''), or (F8'''''').

[0074] As mentioned above, one of the advantages of the formulation according to the present invention is that it contains a large amount of retinol (and therefore a small amount of other components). Another important advantage is that the formulation is oily and not in the form of a classic emulsion.

[0075] When incorporated into end-market products (food, feed, pharmaceuticals, and personal care products), the amount of formulation will vary depending on the amount of retinol required for those end-market products.

[0076] The following examples serve to illustrate the present invention.

[0077] [Examples] All of the following examples are carried out in the following manner: Dissolve and mix retinol and mixed tocopherols under nitrogen at a temperature of 63°C to 65°C for approximately 5 to 10 minutes; Next, heat the solvent to a temperature of 63°C to 65°C.

[0078] Then, the retinol / mixed tocopherol mixture and the solvent are mixed (stirred) at 63°C to 65°C for several minutes, or 2 to 5 minutes, and the formulation is slowly cooled to room temperature.

[0079] Mixed tocopherols is referred to as Mixed Tocopherols 95 (from DSM).

[0080] [Table 1]

[0081] To determine the stability of these formulations, they were stored (at 40°C) for 2 weeks and 12 weeks. The loss of retinol was then measured (initial value was 100%).

[0082] [Table 2]

[0083] The table shows that the formulation according to the present invention is very stable. Formulation 2 and Formulation 3 (comparing an example with BHA and BHT as antioxidants and an example without either antioxidant) show lower stability.

[0084] As described above, the original retinol formulation of the present invention can be incorporated into various compositions.

[0085] For example, in the following personal care compositions listed in the table below (all values ​​are expressed as weight % based on the total weight of the composition):

[0086] [Table 3]

[0087] [Table 4]

[0088] Table 5

Claims

1. A pharmaceutical product, Based on the total weight of the aforementioned preparation, 40 to 75% by weight of retinol, Based on the total weight of the aforementioned preparation, at least one solvent in an amount of 20 to 55% by weight, Based on the total weight of the aforementioned preparation, 1 to 5% by weight of mixed tocopherol and Includes, The above at least one solvent is of formula (I) 【Chemistry 1】 [In the formula, w, x, y, and z are integers that are independent of each other and whose sum is 20, and, R is a chain-like or branched C １０ ~C １８ - Alkyl portion or chain or branched C １０ ~C １８ - This is the alkenil portion. It is a compound of, The aforementioned formulation is a formulation that does not contain antioxidants other than mixed tocopherols.

2. A pharmaceutical product, Based on the total weight of the aforementioned preparation, 40 to 75% by weight of retinol, Based on the total weight of the aforementioned preparation, at least one solvent in an amount of 20 to 55% by weight, Based on the total weight of the aforementioned preparation, 1 to 5% by weight of mixed tocopherol and It consists of, The above at least one solvent is of formula (I) 【Chemistry 2】 [In the formula, w, x, y, and z are integers that are independent of each other and whose sum is 20, and, R is a chain-like or branched C １０ ~C １８ - Alkyl portion or chain or branched C １０ ~C １８ - This is the alkenil portion. It is a compound of, The aforementioned formulation is a formulation that does not contain antioxidants other than mixed tocopherols.

3. The formulation according to claim 1 or 2, comprising 40 to 70% by weight of retinol based on the total weight of the formulation.

4. The above at least one solvent is of formula (I) [In the formula, w, x, y, and z are integers that are independent of each other and whose sum is 20, and, R is a chain C １１ -alkyl moiety, a chain C １７ -alkyl moiety or a chain C １７ -alkenyl moiety], the preparation according to claim 1 or 2.

5. The formulation according to claim 1 or 2, wherein the solvent is polysorbate 20.

6. The formulation according to claim 1 or 2, comprising 25 to 55% by weight of at least one solvent based on the total weight of the formulation.

7. The aforementioned mixed tocopherols Based on the total weight of the aforementioned mixed tocopherols, up to a maximum of 20% by weight of α-tocopherol, Based on the total weight of the aforementioned mixed tocopherols, up to a maximum of 5% by weight of β-tocopherol, Based on the total weight of the aforementioned mixed tocopherols, up to a maximum of 75% by weight of γ-tocopherol, Based on the total weight of the aforementioned mixed tocopherols, up to a maximum of 35% by weight of δ-tocopherol and A formulation according to claim 1 or 2, comprising:

8. A method for producing the preparation described in claim 1 or 2, the following: - A step of mixing the retinol and the mixed tocopherol at 40 to 65°C. - The step of heating at least one of the solvents to a temperature similar to that of the retinol / mixed tocopherol mixture, in the range of 40 to 65°C. - Adding at least one of the solvents to the retinol / mixed tocopherol mixture (or vice versa) at 40-65°C, and mixing at this temperature to obtain the mixture. - A step of slowly cooling the obtained mixture. A method that includes this.

9. Use of the formulation according to at least one claim 1 or 2 in food, feed and personal care products.

10. Food, feed, and personal care products comprising at least one formulation according to claim 1 or 2.

11. A personal care product comprising at least one formulation according to claim 1 or 2.

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