PCSK9を阻害するための組成物および方法

JP7892042B2Inactive Publication Date: 2026-07-17SANOFI SA(FR)
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
SANOFI SA(FR)
Filing Date
2024-10-16
Publication Date
2026-07-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

To provide a dsRNA composition targeting PCSK9, a method for inhibiting PCSK9 gene expression, and a method for treating one or more diseases associated with PCSK9 gene expression.SOLUTION: Provided herein is a double stranded ribonucleic acid (dsRNA) comprising a sense strand comprising a first sequence and an antisense strand comprising a second sequence, where the first and second sequences are complementary, and the first sequence comprises a specific sequence. The dsRNA is optionally a small interfering RNA (siRNA) or a short hairpin RNA (shRNA), and optionally inhibits the expression of proprotein converting enzyme subtilisin-kexin 9 (PCSK9) gene.SELECTED DRAWING: None
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