mRNA配列の最適化方法、装置、mRNA分子、医薬組成物及び用途

JP7892088B2Active Publication Date: 2026-07-17BEIJING BAIDU NETCOM SCI & TECH CO LTD
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
BEIJING BAIDU NETCOM SCI & TECH CO LTD
Filing Date
2025-02-28
Publication Date
2026-07-17

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【0014】 理解すべきこととして、この部分に記述された内容は、本開示の実施例の要点又は重要な特徴を識別することを意図しておらず、本開示の範囲を限定するためのものでもない。本開示の他の特徴は、以下の明細書によって容易に理解されるであろう。

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Abstract

To provide a method and an apparatus for optimizing an mRNA sequence, an mRNA molecule, a pharmaceutical composition, and uses thereof, wherein the present disclosure relates to the technical field of artificial intelligence, specifically to technical fields such as biological computing.SOLUTION: A method for optimizing an mRNA sequence includes: obtaining a first mRNA sequence for synthesizing a protein of interest, where the first mRNA sequence includes a 5' untranslated region sequence and a coding region sequence; and adjusting the 5' untranslated region sequence and the coding region sequence with the goal of maximizing a first score of the first mRNA sequence, so as to obtain an optimized second mRNA sequence for synthesizing the protein of interest. Here, the first score reflects at least one index of translation initiation efficiency, codon adaptation index, and minimum free energy of the first mRNA sequence.SELECTED DRAWING: Figure 1
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