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Abstract

To provide a medical sheet that can contribute to grasp of the precise dimension of tissue in the microsurgery and is easy to arrange in an operative field.SOLUTION: A medical sheet 1 includes: a sheet-like main body 10; and a lattice part 20 having a first pattern 21 containing a plurality of lines extending in a first direction D1, a second pattern 22 containing a plurality of lines extending in a second direction D2 intersecting the first direction, and a lattice internal area 23 surrounded by the first pattern and the second pattern, and having at least one of the first pattern, the second pattern, and the lattice internal area formed on the main body by printing. The pitch of the plurality of lines is 500 μm or less, and the width of the plurality of ines is 150 μm or less. An area ratio of a transparent portion in an effective area Ea1 being a range containing the lattice part is 40% or more and 90% or less.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] This invention relates to the surgical field of microsurgery. configured for various measurements, etc. Regarding the sheet to be used.

Background Art

[0002] Microsurgery using a surgical microscope to dissect and suture delicate tissues such as blood vessels and nerves is widely performed on various organs.

[0003] In microsurgery, a needle with a diameter of about 50 μm to 100 μm and a thread with a diameter of about 10 μm to 2 μm are used. Both the needle and the thread are delicate, and extremely precise work is required. Also, in tissue suturing, it may be required to match the dimensions of the two tissues to be sutured, and it is important to accurately grasp the dimensions of the tissue at the surgical site.

[0004] As a measuring member for medical use, Patent Document 1 describes an adhesive tape with graduations for medical use.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0006] The adhesive tape with graduations described in Patent Document 1 is intended for photographically recording the course of treatment and is used by being attached to the affected area. That is, use on internal organs is not considered. Furthermore, in microsurgery, it is not possible to attach an adhesive tape with graduations to the tissue to be treated, so the adhesive tape with graduations described in Patent Document 1 cannot be applied.

[0007] Furthermore, in order to accurately measure living tissue during microsurgery, it is desirable for the measurement sheet itself to be opaque from the standpoint of visibility. However, on the other hand, when placing the measurement sheet in the surgical field, it can be difficult to see the underlying tissue, making accurate placement challenging.

[0008] In view of the above circumstances, the present invention can contribute to the accurate determination of tissue dimensions during microsurgery, and to the surgical field. Provides easy-to-place sheets. The purpose is to achieve this. [Means for solving the problem]

[0009] The present invention A sheet used by placing it in the operating room for microsurgery, A sheet-like main body, a grid formed on the main body, and a grid formed on the main body Prepare. The grid portion has a first pattern including a plurality of lines extending in a first direction, a second pattern including a plurality of lines extending in a second direction intersecting the first direction, and an internal grid region enclosed by the first pattern and the second pattern, and at least one of the first pattern, the second pattern, and the internal grid region is formed by printing. The pitch of multiple lines is 500 μm or less, and the width of multiple lines is 150 μm or less. This sheet In this case, the area ratio of the transparent portion within the effective region, which includes the grid portion, is between 40% and 90%. This sheet is A printed film containing a temperature-responsive material that is transparent at temperatures below 30°C and becomes colored at temperatures above 30°C is placed within the effective region, and the area ratio is between 40% and 90% when the temperature is below 30°C. [Effects of the Invention]

[0010] The sheet according to the present invention is It can contribute to accurately determining the dimensions of tissues during microsurgery and is easy to position in the surgical field. [Brief explanation of the drawing]

[0011] [Figure 1] This is a schematic plan view of a medical sheet relating to one embodiment of the present invention. [Figure 2] This is a schematic cross-sectional view showing a modified example of the medical sheet. [Figure 3]It is a schematic cross-sectional view showing a modified example of the medical sheet. [Figure 4] It is a schematic cross-sectional view showing an example of the medical sheet. [Figure 5] It is a partially enlarged view of the medical sheet according to the example. [Figure 6] It is a partially enlarged view of the medical sheet according to the comparative example. [Figure 7] It is a partially enlarged view of the medical sheet according to the comparative example.

Mode for Carrying Out the Invention

[0012] Hereinafter, an embodiment of the present invention will be described with reference to FIGS. 1 to 3. FIG. 1 is a plan view of a medical sheet 1 according to the present embodiment. The medical sheet 1 includes a sheet-like main body 10, a lattice portion 20 formed on the main body 10 so as to be visible from the outside, and an information portion 30.

[0013] Each layer of the main body 10 is formed of a biocompatible material. Specific examples include polymers such as silicone, polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polyester, polyvinyl chloride (PVC), polymethyl methacrylate, polyether ether ketone (PEEK), polyether sulfone (PES), polysulfone (PSU), polyphenyl sulfone (PPSU), polyacetal (POM), polyphenyl sulfide (PPS), polyether imide (PEI), polyimide (PI), polylactic acid, polyglycolic acid, polycaprolactone, polycarbonate, polyethylene, polypropylene, copolymers of these polymers, metals such as titanium alloys, stainless steel, cobalt alloys and their oxides, thermosetting elastomers such as silicone rubber, urethane rubber, fluorine rubber, natural rubber, synthetic rubber, and elastic materials such as thermoplastic elastomers such as polystyrene-based (TPS), polyolefin-based (TPO), urethane-based (TPU), polyester-based (TPEE). In addition, the binder of the polymer shown above may contain inorganic powder. The inorganic powder can be silica, alumina, zinc oxide, or titanium oxide. The content of the inorganic powder can be 5% to 70% by weight ratio. An inorganic pigment may also be contained. The form of the main body 10 may be either film-like or plate-like. Furthermore, it may be either flexible with flexibility or rigid with substantially no bending, and can be appropriately selected in consideration of the target organ, procedure, etc.

[0014] There is no particular limitation on the thickness of the main body 10, but it can be 15 μm or more and 2 mm or less. In the case of a highly elastic material, it can be about 0.1 mm to 1.0 mm, and in the case of a low-elasticity material, it can be about 0.02 mm to 0.2 mm.

[0015] In FIG. 1, the planar shape of the main body 10 is a rounded rectangle, but the planar shape is not limited to this, and can be appropriately determined such as a triangle, a circle, etc. The planar shape of the main body 10 is preferably a rounded polygon. In such a form, it is difficult to damage the tissue and it is easy to pick up with tweezers or a manipulator. In addition, the polygon can be a convex hull. If it is a convex hull, it is difficult to catch on the tissue.

[0016] The grid section 20 and the information section 30 are formed on the main body 10 by printing. The grid section 20 is composed of a first pattern 21 consisting of multiple lines extending in a first direction D1 and a second pattern 22 consisting of multiple lines extending in a second direction D2 intersecting the first direction, and the first pattern 21 and the second pattern 22 form a grid. In this embodiment, the main body 10 is entirely transparent, while the grid portion 20 and the information portion 30 are colored. Therefore, all of the multiple grid interior regions 23 surrounded by the first pattern 21 and the second pattern 22 are transparent.

[0017] In this invention, "transparent" means that the average transmittance in the visible light wavelength range is 50% or more. With this level of transmittance, biological tissue beyond the main body 10 can be visually observed, and the type of tissue can be determined with generally accurate accuracy.

[0018] In this embodiment, the lines of the first pattern 21 are arranged at equal intervals, and the lines of the second pattern 22 are also arranged at equal intervals, so that the first direction D1 and the second direction D2 are orthogonal. Furthermore, since the arrangement interval (pitch) P1 of the first pattern 21 and the pitch P2 of the second pattern 22 are the same, the multiple grid interior regions 23 are square. In such a grid section 20, the first pattern 21 functions as a scale provided at equal intervals in the second direction, and the second pattern 22 functions as a scale provided at equal intervals in the first direction. The number of patterns in the grid section 20 and the angles between the patterns are not limited to the configuration shown in Figure 1. It is not fixed and can be set appropriately according to the shape of the grid to be formed.

[0019] The values ​​of pitch P1 and P2 can be determined as appropriate, but from the viewpoint of usefulness in microsurgery, it is preferable that they be at least 1.0 mm or less. When used in surgical procedures that use needles with a diameter of 100 μm or less, it is preferable that pitches P1 and P2 be 600 μm or less. When used in surgical procedures with even higher magnification, such as those using robots, pitches P1 and P2 can be set to 200 μm or less. With the evolution of devices, it is quite possible that surgical procedures with even higher magnification will be performed in the future, but the medical sheet 1 can be suitably adapted by changing the values ​​of pitch P1 and P2. The widths of the multiple lines in each pattern of the grid section 20 are the same, and can be, for example, 100 μm or less. In practice, considering the accuracy of printing, etc., they are set within ±5% of the set value. With such settings, even when the grid section 20 is observed under magnification during surgery, the irregularities at both ends in the width direction of the lines constituting the grid section 20 are not noticeable, and it stabilizes in a nearly straight line.

[0020] The information unit 30 displays information about the medical sheet 1, including information about the specifications of the grid section 20. In this embodiment, the information unit 30 consists of three strings: "P 500" and "L 50". "P 500" indicates that the pitch (P1=P2 in this embodiment) is 500 μm, and "L 50" indicates that the line widths of the first pattern 21 and the second pattern 22 are 50 μm.

[0021] In this embodiment, the information unit 30 is provided only in a portion of the grid interior area as shown in Figure 1, but the number and spacing of the information units can be set as appropriate. Since the medical sheet 1 may be used by cutting out a smaller portion depending on the size of the surgical field or operating area, it is preferable to set the number and spacing of the information units so that at least one information unit is present in the cut-out area. The information unit 30 has an arbitrary configuration and may be omitted.

[0022] The colors of the grid section 20 and the information section 30 are preferably complementary colors of biological tissue. These complementary colors can range from blue to yellow-green, including blue, greenish-blue, blue-green, bluish-green, green, yellowish-green, and yellow-green. These colors from blue to yellow-green correspond to B, BG, G, and GY in the Munsell color system. By making the colors of the main body 10 range from blue to yellow-green, biological tissue becomes easier to see. Specifically, the ranges of L*, a, and b in the L*ab color space of the main body 10 are preferably 25 to 80, -80 to 0, and -50 to 50, respectively. In the lattice section 20 and the information section 30, it is preferable that the spectral reflectance in the visible light spectrum (wavelength band approximately 350 nm to 800 nm) from 570 nm to 800 nm is 20% or less. Low brightness is preferable because it provides good contrast with biological tissue. The peak reflectance of visible light in the main body having such brightness is generally 10% or less.

[0023] The ink for forming the grid portion 20 and the information portion 30 comprises a color-developing pigment and a binder. Both organic and inorganic pigments can be used as colorants. As inorganic pigments, oxides, hydroxides, sulfides, selenides, ferrocyanides of metals such as titanium, zinc, gold, silver, copper, and iron, or chromates, sulfates, carbonates, silicates, and phosphates of these metals can be used. Furthermore, examples include the elemental form or alloys thereof of the above-mentioned metals, carbon, and pearl pigments such as bismuth oxychloride, titanium mica, and fish scale foil. Among these, titanium dioxide (titania), zinc oxide, talc, silica, mica, alumina, barium sulfate, calcium carbonate, magnesium carbonate, barium silicate, calcium silicate, metal soaps, and silicones are preferred due to their biocompatibility. Examples of organic pigments include nitroso-based, nitro-based, azo-based, lake-based, phthalocyanine-based, condensed polycyclic materials, and other carbon compounds.

[0024] A resin can be used as a binder. The resin can be a composition, and the composition can be a mixture of oligomers and polymers. The resin can be soluble. The resin may also be a curable resin. The curable resin can be an ionizing radiation curable resin or a thermosetting resin. The ionizing radiation curable resin can be an ultraviolet curable resin or an electron beam curable resin. The type of resin can be an acrylic resin, urethane resin, epoxy resin, polyester resin, thiol resin, or a mixture thereof. As for the acrylic resin, a fluoropolymer acrylic resin, a silicone polymer acrylic resin, an epoxy acrylate resin, an acrylonitrile styrene resin, or a mixture thereof can be used. Other resins that can be used include methylstyrene resin, fluorene resin, polypropylene, PET (polyethylene terephthalate), PC (polycarbonate), PS (polystyrene), COC (cyclic olefin copolymer), COP (cycloolefin polymer), MS (styrene methacrylate copolymer), AS (acrylonitrile styrene copolymer), PEN (polyethylene naphthalate), PI (polyimide), phenolic resin, melamine resin, epoxy resin, alkyd, etc.

[0025] In addition to the above, engineering plastics such as PBT (polybutylene terephthalate), POM (polyoxymethyl), PA (polyamide), and PPS (polyphenyl sulfide), as well as super engineering plastics, can also be used as binders.

[0026] For the ink used to form the grid portion 20 and the information portion 30, it is preferable to use either an aqueous ink or a non-aqueous ink depending on the surface characteristics of the main body 10. If the surface of the main body 10 is hydrophilic, it is preferable to use an aqueous ink. If the surface of the main body 10 is hydrophobic, it is preferable to use a non-aqueous ink. Various solvents can be used to adjust the solid content and viscosity of inks. For example, water (purified water) or alcohol can be used for water-based inks. For non-water-based inks, solvents with high boiling points that do not evaporate easily at room temperature (aliphatic hydrocarbons, glycol ethers, higher alcohols, etc.) or solvents with low boiling points that evaporate easily at room temperature (MEK, ethanol, acetone, etc.) can be used alone or in combination. Other solvents such as dodecane, tetradecane, and toluene can also be used.

[0027] The ink may contain organic or inorganic fine particles. Specific examples include acrylic particles, styrene particles, styrene-acrylic particles and their crosslinked products, melamine-formaldehyde condensate particles, polyurethane particles, polyester particles, silicone particles, fluorine particles, epoxy particles and their copolymers, clay compound particles such as smectite, kaolinite, and talc, inorganic oxide particles such as silica, titanium dioxide, alumina, silica-alumina, zirconia, zinc oxide, barium oxide, and strontium oxide, inorganic fine particles such as calcium carbonate, barium carbonate, magnesium carbonate, barium chloride, barium sulfate, barium nitrate, barium hydroxide, aluminum hydroxide, strontium carbonate, strontium chloride, strontium sulfate, strontium nitrate, strontium hydroxide, and glass particles. These particles can be used individually or in appropriate combinations. Furthermore, they may be used after surface treatment such as coating or vapor deposition.

[0028] There are no particular restrictions on the printing method for forming the grid section 20 and the information section 30. Examples of printing methods include offset printing, gravure printing, flexographic printing, screen printing, gravure offset printing, inverted offset printing, screen offset printing, pad printing, and inkjet printing. Of these, gravure offset printing and screen offset printing are particularly suitable because they can stably form narrow lines.

[0029] The ink forming the grid portion 20 and the information portion 30 is preferably made of a biocompatible material. Alternatively, the biocompatibility of the medical sheet 1 can be ensured by forming the grid portion 20 and the information portion 30 with an ink that is not made of a biocompatible material, and then covering the ink portion with a transparent, biocompatible coating. In this case, the coating may cover only the grid portion 20 and the information portion 30, or it may cover the entire surface of the main body 10. As the coating material, a biocompatible material that can be used for the ink forming the main body 10, the grid portion 20, and the information portion 30 can be used. Preferably, silicone resin or fluororesin can be used as examples.

[0030] In this embodiment, the area ratio of the transparent portion within the effective area of ​​the medical sheet is 40% to 90%. The "effective area" refers to the area where the dimensions of the placed tissue can be measured based on the grid portion 20, and specifically means the smallest convex hull area that covers all of the grid portion 20 in a plan view of the medical sheet. In this embodiment, the range Ea1 shown in Figure 1 is the effective area.

[0031] The operation of the medical sheet 1, configured as described above, will now be explained. The medical sheet 1 is placed in the operating room where the procedure is to be performed, either as is or after being cut to an appropriate size. By positioning the medical sheet 1 at an appropriate location on the organ or tissue to be treated, the dimensions of the organ or tissue can be determined based on the grid section 20 and the information section 30. Based on the information obtained, the user can select tissue, adjust its dimensions, etc.

[0032] When placing the medical sheet 1 in the operating room, it is preferable to place it in an optimal location that does not interfere with subsequent procedures. Since the area ratio of the transparent portion of the medical sheet 1 in the effective area Ea1 is between 40% and 90%, the tissue beneath can be seen through the sheet. As a result, the conditions of the operating field, including the type and condition of the tissue, can be grasped through the sheet, and the sheet can be placed in the optimal position within the operating field.

[0033] The area ratio of the transparent portion within the effective region can be adjusted to a desired value, for example, by the following method. • Change the line width and pitch of the lines in the grid section. As shown in the modified example of medical sheet 1A in Figure 2, the grid portion 20A is made transparent, and the internal grid region 23A is made opaque. The effective area of ​​medical sheet 1A is Ea2 as shown in Figure 2. • The grid area is made opaque, while a portion of the area inside the grid is made opaque.

[0034] In the modified medical sheet 1B shown in Figure 3, there are two types of internal grid regions: a transparent internal grid region 23a that is not printed on, and an internal grid region 23b on which a printed film 25 is formed. The printed film 25 is transparent at temperatures below 30°C, and becomes opaque and develops color at temperatures above 30°C. This allows the area ratio of the transparent portion in the effective area Ea3 of the medical sheet 1B to be between 40% and 90% at temperatures below 30°C, and less than 40% at temperatures above 30°C. As a result, when placing the medical sheet 1B in the surgical field, it is possible to ensure that the condition of the surgical field can be observed through the sheet, and after placement, the area ratio of the transparent part is reduced to improve the contrast with the tissue placed on the sheet, enabling accurate measurements and other operations.

[0035] In the medical sheet 1B, a certain level of brightness difference between the printed film 25 and the grid portion 20 is desirable for good contrast. For example, a difference of about 30 points in the average reflectance (%) of visible light results in good contrast. Alternatively, the contrast between the printed film 25 and the grid portion 20 can be a color density difference of 0.1 or more and 2.0 or less, and to further improve visibility, a difference of 0.5 or more and 1.5 or less is preferable.

[0036] The printed film 25 can be formed with an ink containing a temperature-responsive material that is transparent at temperatures below 30°C and produces color at temperatures above 30°C. Examples of temperature-responsive materials include inorganic compounds such as mercury iodide and dimethylammonium compounds, liquid crystals such as cholesterol derivatives and cyanobiphenyls, leuco dyes, spirooxazines, salicyldeneanilines, bianthrones, and polydiacetylenes. These are substances that exhibit reversible or unidirectional color changes in response to intermolecular forces, transitions, dehydration reactions, stereocoordination, and changes in molecular structure. These temperature-responsive materials may be used alone as pigments or dyes, or they may be added to inks after their surfaces are coated with another substance, such as microcapsules.

[0037] The ink containing the temperature-responsive material may contain the above-mentioned organic and inorganic pigments, to the extent that it maintains transparency at temperatures below 30°C. Organic and inorganic pigments can be used individually or in combination.

[0038] The ink containing the temperature-responsive material may further contain the aforementioned organic or inorganic fine particles, as long as it maintains transparency at temperatures below 30°C. Organic and inorganic microparticles can be used individually or in combination of multiple types.

[0039] The height of the grid section 20, the information section 30, and the printed film 25 (the thickness of the layer formed on the main body 10) is preferably 1 μm to 10 μm for ease of visibility. Examples of cross-sectional shapes of the grid section 20 include semicircular, semi-elliptical, triangular, trapezoidal, rectangular, and trapezoidal or rectangular shapes with a convex curved top. If there are edges at the corners of the cross-sectional shape, blood and cleaning fluid tend to remain on the grid section 20 due to surface tension, but if the corners of the cross-sectional shape are rounded, blood and cleaning fluid are less likely to accumulate on the grid section 20, which is preferable. Furthermore, if the shape is semicircular, semi-elliptical, triangular, or trapezoidal, blood and cleaning fluid are less likely to accumulate on the grid section 20 and flow more easily from the medical sheet, making it easier to maintain the visibility of the grid section 20 during microsurgery. The height of the grid section 20 can be easily adjusted by overlapping the printing in the same location when printing ink onto the main body 10.

[0040] The medical sheet according to the present invention will be further described with reference to examples. The present invention is not limited in any way by the specific details of the following examples.

[0041] (Example 1) Figure 4 schematically shows the medical sheet 1C according to Example 1. A transparent silicone rubber sheet shaped like an isosceles triangle in plan view was used as the main body 10. The isosceles triangle had a base of 10 mm and a height of 50 mm, and the thickness of the main body 10 was 0.5 mm. The visible light transmittance of the main unit 10 is 90% as an average transmittance in the range of light wavelengths from 400 to 700 nm.

[0042] A grid section 20 and an information section 30 were formed on the main body 10 by gravure offset printing using green ink (binder: silicone resin, pigment: zinc-based). The effective area Ea4 in Example 1 is an isosceles triangle with a base of 7 mm and a height of 45 mm. A solvent with a standard drying rate was used for the green ink, and the solid content was 20%. The settings for the grid section 20 and the information section 30 were as follows. The area ratio of the transparent portion in the effective area Ea4 is 55%. • First pattern First direction D1: Parallel to the base of the main body 10. Pitch P1: 100 μm Line width: 25 μm • Second pattern Second direction D2: Perpendicular to the first direction D1 Pitch P2: 100 μm Line width: 25 μm • Information section string P 100 L 25 The grid interior region 23 defined by the grid section 20 is a square with sides of 75 μm (pitch 100 μm), and it is difficult to fit all of the above strings within it. Therefore, as shown in Figure 5, the grid section was partially removed and formed within the range of multiple grid interior regions. The information section 30 is arranged at a frequency of every 5 grids vertically and every 5 grids horizontally.

[0043] When the medical sheet 1C of Example 1 was placed in the surgical field of an animal using a binocular microscope with a magnification of 40x, the living tissue could be clearly visualized through the medical sheet 1C, and it was possible to accurately position it in the desired location. When pig blood vessels were placed on medical sheet 1A and observed with a binocular microscope, dimensions such as length and diameter could be easily determined based on the grid section 20 and the information section 30.

[0044] (Example 2) The plan view of Example 2 is generally the same as that of the medical sheet 1A shown in Figure 2, and has a transparent grid portion 20A and an opaque grid interior region 23A. A square PET film was used as the main body 10. The length of one side of the square was 25 mm, and the thickness of the main body 10 was 0.2 mm. The visible light transmittance of the main unit 10 is 98% as an average transmittance in the range of light wavelengths from 400 to 700 nm.

[0045] A grid interior region 23A was formed on the main body 10 by screen offset printing using metallic ink (pigment silver particles). The effective region Ea2 in Example 2 is a square with sides parallel to the first direction D1 of 20 mm and sides parallel to the second direction D2 of 20 mm. The configuration of the grid section 20A and the information section 30 is as follows, and the area ratio of the transparent portion in the effective region Ea2 is 70%. ·Grate internal area 23A The structure was a square with sides of 160 μm, and the elements were arranged with a 140 μm gap between them in the first direction D1 and the second direction D2. • First pattern First direction D1: Parallel to the base of the main body 10. Pitch P1: 300 μm Line width: 140 μm • Second pattern Second direction D2: Perpendicular to the first direction D1 Pitch P2: 300 μm Line width: 140 μm • Information section string P 300 L 140 The information unit 30 was formed in one location within the grid section 20A.

[0046] After forming the lattice interior region 23A and the information section 30, a silicone resin was applied to the entire surface and dried to form a coating that covers the lattice interior region 23A and the information section 30.

[0047] When the medical sheet according to Example 2 was placed in the surgical field of an animal using a 40x magnification binocular microscope, the biological tissue could be clearly visualized through the medical sheet, and it could be accurately positioned in the desired location. No decrease in visibility due to the coating was observed. When pig nerves were placed on a medical sheet and observed with a binocular microscope, dimensions such as length and diameter could be easily determined based on the grid section 20A and the information section 30.

[0048] (Example 3) The plan view of Example 3 is generally the same as that of the medical sheet 1B shown in Figure 3. A rectangular transparent silicone rubber sheet was used as the main body 10. The rectangle had a long side of 15 mm and a short side of 10 mm, and the thickness of the main body 10 was 0.5 mm. The visible light transmittance of the main unit 10 is 90% as an average transmittance in the range of light wavelengths from 400 to 700 nm.

[0049] On the main body 10, the grid section 20 and the information section 30 were formed by gravure offset printing using black ink (binder: silicone resin, pigment: carbon-based). The effective area Ea3 in Example 3 is a rectangle with sides parallel to the first direction D1 of 10 mm and sides parallel to the second direction D2 of 5 mm. The settings for the grid section 20 and the information section 30 are as follows. • First pattern First direction D1: Parallel to the long side of the main body 10. Pitch P1: 400 μm Line width: 40 μm • Second pattern Second direction D2: Perpendicular to the first direction D1 Pitch P2: 400 μm Line width: 40 μm • Information section string P 400 L 40 Since the size of the grid interior region is large enough to print all of the above string, the information unit 30 was formed in one of the grid interior regions 23a.

[0050] Next, a printed film 25 made of temperature-responsive green ink (binder: silicone resin, pigment: green pigment derived from leuco dye) was formed in the lattice interior region 23b by screen printing. The printed film 25 is transparent at temperatures below 30°C and becomes opaque green at temperatures above 30°C. In the medical sheet according to Example 3, the area ratio of the transparent portion in the effective region Ea3 at temperatures below 30°C is 80%.

[0051] Finally, silicone resin was applied to the entire surface and dried to form a coating that covered the entire effective region Ea3.

[0052] When the medical sheet according to Example 3 was placed in the surgical field of an animal using a 40x magnification binocular microscope, the biological tissue could be clearly visualized through the transparent printed film 25, and the sheet could be accurately positioned as desired. After a few minutes in the surgical field, the printed film 25 discolored and became opaque due to the rise in temperature. When pig blood vessels were placed on a medical sheet and observed with a binocular microscope, dimensions such as length and diameter could be easily determined based on the grid section 20 and information section 30. Due to the discoloration of the printed film 25, there were almost no transparent areas when the pig blood vessels were placed on the sheet, resulting in good contrast between the sheet and the blood vessels, and extremely good visibility of the biological tissue.

[0053] (Comparative Example 1) Figure 6 schematically shows the comparative example medical sheet 1D. Comparative Example 1 differs from Example 1 only in the configuration of the grid. Specifically, it is as follows, and the area ratio of the transparent portion in the effective region Ea4 is 10%. • First pattern First direction D1: Parallel to the long side of the main body 10. Pitch P1: 100 μm Line width: 90 μm • Second pattern Second direction D2: Perpendicular to the first direction D1 Pitch P2: 100 μm Line width: 90 μm • Information section string P 100 L 90

[0054] When the medical sheet 1D of Comparative Example 1 was placed in the surgical field of an animal using a 40x magnification binocular microscope, the living tissue could be clearly visualized through the medical sheet 1C, and it was possible to accurately position it in the desired location. However, when pig blood vessels were placed on medical sheet 1D and observed with a binocular microscope, it was difficult to determine dimensions such as length and diameter due to the thick line width.

[0055] (Comparative Example 2) Figure 7 schematically shows the comparative example medical sheet 1E. Comparative example 2 differs from example 2 only in the configuration of the grid portion 20A and the grid interior region 23A. Specifically, it is as follows, and the area ratio of the transparent portion in the effective region Ea2 is 99%. ·Grate internal area 23A The sample was a square with sides of 20 μm, and was placed with a 280 μm gap between it in the first direction D1 and the second direction D2. • First pattern First direction D1: Parallel to the base of the main body 10. Pitch P1: 300 μm Line width: 280 μm • Second pattern Second direction D2: Perpendicular to the first direction D1 Pitch P2: 300 μm Line width: 280 μm • Information section string P 300 L 280

[0056] When attempting to place the medical sheet 1E of Comparative Example 2 into the surgical field of an animal using a binocular microscope with a magnification of 40x, it was difficult to adequately visualize the biological tissue through the medical sheet 1E, making it challenging to position it in the desired location. When pig blood vessels were placed on medical sheet 1D and observed with a binocular microscope, the large amount of transparent area made it difficult to distinguish the blood vessels on the sheet from the tissue beneath, resulting in significantly reduced visibility. The small size of the grid interior region 23A and the long spacing between the elements also made it difficult to determine the dimensions of the blood vessels on the sheet, such as their length and diameter.

[0057] Although each embodiment of the present invention has been described in detail above with reference to the drawings, the specific configuration is not limited to these embodiments, and modifications and combinations of the configuration that do not depart from the spirit of the present invention are also included. Some modifications are given below as examples, but these are not all, and other modifications are also possible. Two or more of these modifications may be combined as appropriate.

[0058] • In the examples described above, there are areas without a grid on the peripheral edge of the main body when viewed from above, but this is not essential, and a grid may be provided over the entire surface of the main body. • Small protrusions may be provided on the periphery of the main body to facilitate grasping with forceps or similar tools.

[0059] • The visible light reflectance of the printed portion of the grid may have multiple peaks. Even in this case, if at least one peak is present within the wavelength range of 450 nm to 570 nm, good contrast with biological tissue will be achieved, resulting in excellent visibility.

[0060] In a configuration where the grid portion is transparent, a temperature-responsive printed film may be formed on the grid portion. The printed film does not necessarily have to be opaque; it may be transparent while still being colored.

[0061] Even if the ink forming the lines and information areas is biocompatible, a coating may still be applied. During use of medical sheets, saline solution or the like is continuously applied to prevent drying, so the coating can suppress attacks on the lines and information areas by saline solution or the like.

[0062] The total thickness of the medical sheet, including the main body and the image area, can be, for example, between 0.02 mm and 1.0 mm. A thickness of 0.02 mm or more ensures ease of transport during manufacturing and makes it easier to guarantee dimensional accuracy of the image area. A thickness of 1.0 mm or less allows for greater flexibility, making it suitable for use in microsurgery.

[0063] The grid section may have multiple regions with different line widths and pitches, and information sections corresponding to each region may be formed therein.

[0064] The coating does not necessarily have to cover the entire effective area; for example, it may cover only the parts formed by printing. [Explanation of symbols]

[0065] 1, 1A, 1B, 1C Medical Sheets 10. Main unit 20, 20A grid section 21 First Pattern 22. Second Pattern 23, 23A, 23a, 23b lattice internal area 25 Printed film 30 Information Department Ea1, Ea2, Ea3, Ea4 Effective Area

Claims

1. A sheet to be placed and used in the operating room for microsurgery, A sheet-like body, A grid portion having a first pattern including a plurality of lines extending in a first direction, a second pattern including a plurality of lines extending in a second direction intersecting the first direction, and a grid interior region enclosed by the first pattern and the second pattern, wherein at least one of the first pattern, the second pattern, and the grid interior region is formed on the main body by printing, Equipped with, The pitch of the aforementioned plurality of lines is 500 μm or less. The width of the aforementioned plurality of lines is 150 μm or less. The area ratio of the transparent portion within the effective region, which includes the aforementioned grid portion, is 40% or more and 90% or less. A printed film containing a temperature-responsive material that is transparent at temperatures below 30°C and becomes colored at temperatures above 30°C is placed within the effective region. At temperatures below 30°C, the area ratio is 40% or more and 90% or less. Seat.

2. The system further includes an information unit that displays at least one of the widths of the plurality of lines, the spacing between the plurality of lines, the dimensions of the grid interior region, and the spacing between the grid interior region. The sheet according to claim 1.

3. The system further comprises a coating that covers the portion of the grid formed by printing. The sheet according to claim 1.

4. At least one peak in the visible light reflectance of the portion of the lattice formed by printing is located within the wavelength range of 450 nm to 570 nm. The sheet according to claim 1.

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