Composition for improving skin compatibility

Abstract

To provide a novel composition for improving skin compatibility.SOLUTION: The present invention provides a composition for improving skin compatibility, comprising honey, wherein the contact angle of water on skin after application of the composition is 30 degrees or less.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a composition for improving skin affinity.

Background Art

[0002] Since the stratum corneum of the skin acts as a barrier against water evaporation from the body and the entry of viruses, substances, etc. from the outside, it is difficult to deliver a sufficient amount of a compound, such as a pharmaceutical or a cosmetic, from outside the skin into the skin. On the other hand, there are also cosmetics (also called booster skin care lotions or introduction lotions (introduction skin care lotions), etc.) that aim to promote the penetration of the components in the next-applied formulation into the skin. Such cosmetics contain, for example, surfactants, polyols, and lactic acid.

[0003] For example, Patent Document 1 discloses a pretreatment method for skin care, which comprises: (1) a step of washing the skin with a skin cleansing agent and then rinsing off the cleansing agent with water; (2) a step of applying, while shaking to a dispersed state, a skin rinse composition having a liquid oil phase and an aqueous phase at room temperature, wherein the oil phase is separated into two layers, the oil phase is 3 to 30% by mass in the composition, and contains 1% by mass or more of a higher fatty acid that is liquid at room temperature, onto the wet skin; and (3) a step of rinsing off the skin rinse composition with water.

[0004] Furthermore, relating to compositions applied to the skin, for example, Patent Document 2 discloses a ferment obtained by fermenting honey and chamomile or a processed product thereof with Lactobacillus kunkii, and states that this ferment can be used to improve skin barrier function, moisturize skin, improve skin elasticity, improve skin dullness, improve skin wrinkles, improve rough skin, prevent skin aging, improve skin texture, and improve sensitive skin. In addition, Non-Patent Document 1 describes a cream containing bioengineered medicinal honey, which has been proven to kill multidrug-resistant bacterial strains by delivering reactive oxygen species, and which exhibits a low contact angle on pig skin while maintaining its bactericidal effect, and the cream spreads well on the skin surface. [Prior art documents] [Patent Documents]

[0005] [Patent Document 1] Patent No. 5022583 [Patent Document 2] Patent No. 6888835 [Non-patent literature]

[0006] [Non-Patent Document 1] O'Farrell C, et al., “Formulationof an antibacterial topical cream containing bioengineered honey that generatesreactive oxygen species.” Biomater Adv. 2022 Feb;133:112664. doi:10.1016 / j.msec.2022.112664. Epub 2022 Jan 20. [Overview of the Initiative] [Problems that the invention aims to solve]

[0007] The present invention aims to provide a novel composition for improving skin compatibility. [Means for solving the problem]

[0008] As a result of diligent research conducted by the inventors to achieve the above objective, they discovered that after applying honey to an artificial skin model, the contact angle of water with respect to the honey-coated artificial skin model becomes 30 degrees or less, thus completing the present invention.

[0009] In other words, the present invention relates to, for example, the following inventions. [1] A composition containing honey for improving skin compatibility, wherein the contact angle of water with the skin to which the composition is applied is 30 degrees or less. [2] The composition according to [1], further comprising royal jelly, butylene glycol, and pentylene glycol. [3] The composition according to [1] or [2], further containing a lactic acid bacillus fermented extract of honey. [4] The above honey lactic acid bacilli fermentation extract is obtained by fermenting honey and chamomile flowers using Lactobacillus kunkii, as described in [3]. [5] The composition according to any one of [1] to [4], wherein the honey is manuka honey and / or acacia honey. [Effects of the Invention]

[0010] According to the present invention, it is possible to provide a novel composition for improving skin compatibility. [Modes for carrying out the invention]

[0011] The embodiments for carrying out the present invention will be described in detail below. However, the present invention is not limited to the following embodiments.

[0012] [Composition] The composition for improving skin compatibility according to this embodiment (hereinafter also referred to as "the composition") contains honey, and the contact angle of water with the skin to which the composition is applied is 30 degrees or less.

[0013] The composition according to this embodiment has a water contact angle of 30 degrees or less with respect to the skin to which the composition is applied, and has the effect of improving skin compatibility. Here, in this specification, "improving skin compatibility" means improving the compatibility of a hydrophobic or hydrophilic liquid with the skin, and this can be evaluated by whether the water contact angle with respect to the skin to which the composition is applied, when water is dropped onto the skin, is smaller than the contact angle with respect to skin to which the composition is not applied. If the water contact angle is smaller before and after application of the composition, it can be determined that skin compatibility has improved. In addition, the water contact angle is generally used as an indicator for evaluating wettability. Therefore, the composition according to this embodiment can also be described as a composition for improving the wettability of the skin.

[0014] In measuring the water contact angle, the skin to which the composition according to this embodiment is applied may be natural skin or artificial skin. Furthermore, natural skin may be... To etc. The material may be animal skin, preferably human skin, and if it is human skin, it may be skin from the cheek, forearm, etc., and preferably hairless (hair removed) skin. In the case of artificial skin, for example, it may be a mimic of human skin, and may be artificial skin differentiated by iPS cells, or an artificial skin model made of urethane, etc. When determining whether the contact angle of water with respect to the skin to which the composition is applied is 30 degrees or less, the skin is forearm skin or an artificial skin model made of urethane, 0.1 g of the composition is uniformly applied to a 5 cm x 5 cm area on the skin, 2 μl of water is dropped on it after 1 hour, and the contact angle is measured immediately after dropping the water (pure water such as distilled water) (1000 milliseconds later).

[0015] The measurement of the water contact angle can be carried out using, for example, an automatic contact angle meter DMo-602 (manufactured by Kyowa Interface Science Co., Ltd.). The water contact angle can be measured, for example, by the droplet method. The water contact angle can be analyzed (calculated), for example, by the θ / 2 method, the tangent method, etc.

[0016] Although the human skin varies depending on the site, the water contact angle is around 60 degrees to 102 degrees. Also, generally, the water contact angle on the human forearm is around 90 degrees, and artificial skin also has a water contact angle close to that of the human forearm. It is preferable to use skin of animals other than humans with a water contact angle around 90 degrees. The composition according to the present embodiment preferably reduces the water contact angle with respect to the skin when water is dropped onto the skin (muscle) to which the composition is applied, as compared with the water contact angle with respect to the skin to which the above composition is not applied, by 50 degrees or more, 55 degrees or more, 60 degrees or more, or 65 degrees or more.

[0017] The composition according to the present embodiment only needs to have a water contact angle with respect to the skin to which the composition is applied of 30 degrees or less. For example, it may be 28 degrees or less, 26 degrees or less, 24 degrees or less, 22 degrees or less, 20 degrees or less, 18 degrees or less, 16 degrees or less, 14 degrees or less, or 13 degrees or less, and may also be 0 degrees or more, 1 degree or more, 3 degrees or more, or 5 degrees or more.

[0018] The composition according to the present embodiment is for application to the skin, and can be applied to any part of the skin. In this specification, "apply" may mean coating or spraying.

[0019] Honey is produced mainly from honey collected by bees from plant nectar, sap, secretions of insects parasitic on plants, etc.

[0020] The type of honey contained in the composition according to the present embodiment is not particularly limited. For example, it includes manna honey, ulmo honey, manuka honey, acacia honey, bodajyu honey, rewarewa honey, hundred flower honey, clover honey, orange honey, lotus honey, rosemary honey, sunflower honey, rapeseed honey, coffee honey , PaYou can use honey such as coriander honey, horse chestnut honey, buckwheat honey, sumac honey, holly honey, holly honey, and Japanese pepper honey. The honey is preferably manuka honey and / or acacia honey.

[0021] Manuka honey is honey collected from the flowers of the manuka plant (Leptospermum scoparium), which belongs to the genus Leptospermum in the Myrtaceae family. Acacia honey is honey collected from the flowers of the black locust tree (Robinia pseudoacacia), which belongs to the genus Robinia in the Fabaceae family.

[0022] The type of bee used to harvest honey is not particularly limited. Honey can be obtained, for example, as a beekeeping product in accordance with conventional laws.

[0023] While stored in the beehive, honey is generally kept at around 35°C by the bees' body temperature. After being harvested from the beehive, honey is generally heated as needed to reduce its viscosity, facilitate transportation and packaging, and melt any crystals.

[0024] Honey after harvesting may be used as is, or it may be purified by removing proteins, waxes, debris, bee and hive residue, filtering, extraction with organic solvents, fractionation, sterilization, concentration, etc., before or after heating.

[0025] While honey has been known to have moisturizing properties, it was previously unknown that it also has properties that improve skin absorption.

[0026] The honey content in the composition according to this embodiment may be, for example, 5% by mass or more, 10% by mass or more, 15% by mass or more, 20% by mass or more, 25% by mass or more, or 30% by mass or more, relative to the total amount of the composition, and may also be 100% by mass or less, 90% by mass or less, 80% by mass or less, 70% by mass or less, or 60% by mass or less.

[0027] The composition according to this embodiment may further contain royal jelly, butylene glycol, and pentylene glycol. This reduces the contact angle of water with the skin to which the composition according to this embodiment is applied, thereby improving skin compatibility.

[0028] The royal jelly used in this invention includes raw royal jelly, dried royal jelly, dried royal jelly powder, enzyme-treated royal jelly, royal jelly extract, and fermented royal jelly. The royal jelly may be sourced from any of the following countries: European countries, Oceania countries, the United States, Brazil, Japan, China, or other Asian countries.

[0029] Dried royal jelly powder is made by drying and pulverizing fresh royal jelly. Any known drying method used in general food processing can be used, including natural drying such as air drying or sun drying, forced drying by heating with electricity, or freeze-drying. Freeze-drying is preferred.

[0030] Enzyme-treated royal jelly is royal jelly treated with a protease (protein-degrading enzyme). Preferably, it is a low-allergen enzyme-treated royal jelly in which allergic reactions caused by proteins contained in royal jelly are suppressed by protease treatment. Therefore, in addition to the protease hydrolysates of proteins contained in royal jelly, enzyme-treated royal jelly may contain organic acids such as saturated and unsaturated fatty acids, lipids, sugars, vitamins, and various minerals.

[0031] The royal jelly used in the production of enzyme-treated royal jelly is not particularly limited and may include, for example, raw royal jelly, royal jelly powder obtained by drying and pulverizing raw royal jelly, or raw royal jelly extracted with water or aqueous ethanol.

[0032] Enzyme-treated royal jelly can be produced by treating royal jelly raw material with an enzyme having at least endopeptidase activity, an enzyme having at least exopeptidase activity, and / or an enzyme having both endopeptidase and exopeptidase activity.

[0033] Examples of proteolytic enzymes that possess at least endopeptidase activity include endopeptidases derived from animals (e.g., trypsin, chymotrypsin, etc.), plants (e.g., papain, etc.), and microorganisms (e.g., lactic acid bacteria, yeast, mold, Bacillus subtilis, actinomycetes, etc.).

[0034] Examples of proteolytic enzymes that possess at least exopeptidase activity include carboxypeptidases, aminopeptidases, exopeptidases derived from microorganisms (e.g., lactic acid bacteria, Aspergillus species, Rhizopus species, etc.), and pancreatin and pepsin, which also possess endopeptidase activity.

[0035] Among these various enzymes, preferred examples of enzymes possessing both exopeptidase and endopeptidase activity include Streptomyces griseus-produced peptidase (product name: Actinase AS), Aspergillus oryzae-produced peptidase (product names: Protease A, Flavorzyme, Proteax), and Aspergillus melleus-produced peptidase (product name: Protease P). Preferred examples of enzymes possessing exoprotease activity include Aspergillus oryzae-produced peptidase (product names: Umamizyme G, Promod 192P, Promod 194P, Sumizyme FLAP), and Aspergillus sojae-produced peptidase (product name: Sternzyme). Examples include peptidases produced by Aspergillus species (product name: Cocrase P) and peptidases produced by Rhizopus oryzae (product name: Peptidase R). Furthermore, preferred examples of enzymes possessing endoprotease activity include peptidase produced by Bacillus subtilis (trade names: Orientase 22BF, Nucleicin), peptidase produced by Bacillus licheniformis (trade name: Alcalase), peptidase produced by Bacillus stearothermophilus (trade name: Protease S), peptidase produced by Bacillus amyloliquefaciens (trade name: Neutralase), and peptidase produced by Bacillus species (trade name: Protamex).

[0036] Enzymatic treatment to reduce the allergenicity of royal jelly can be carried out, for example, in accordance with the descriptions in Japanese Patent Publication No. 2007-295919 and Japanese Patent Publication No. 2007-295920.

[0037] Royal jelly extract is obtained by extracting royal jelly (including raw, dried, and pulverized forms) with water or aqueous ethanol, etc.

[0038] Royal jelly fermented products can be produced by conventional methods using microorganisms such as yeast and lactic acid bacteria.

[0039] The royal jelly content in the composition according to this embodiment may be, for example, 0.001% by mass or more, 0.005% by mass or more, 0.01% by mass or more, 0.05% by mass or more, 0.1% by mass or more, or 0.2% by mass or more, relative to the total amount of the composition, and may also be 10% by mass or less, 5% by mass or less, 1% by mass or less, or 0.5% by mass or less.

[0040] Butylene glycol, also known as butanediol, is a compound often used as a humectant. In this specification, butylene glycol refers to 1,3-butylene glycol. The butylene glycol content in the composition according to this embodiment may be, for example, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 2% by mass or more, 3% by mass or more, 4% by mass or more, 5% by mass or more, 6% by mass or more, 7% by mass or more, or 8% by mass or more, and may also be 30% by mass or less, 25% by mass or less, 20% by mass or less, 15% by mass or less, or 10% by mass or less.

[0041] Pentylene glycol, also known as 1,2-pentanediol, is a compound often used as a humectant. The pentylene glycol content in the composition according to this embodiment may be, for example, 0.01% by mass or more, 0.05% by mass or more, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, or 2% by mass or more, and may also be 10% by mass or less, 8% by mass or less, 6% by mass or less, 4% by mass or less, or 2.5% by mass or less.

[0042] The composition according to this embodiment may further contain a lactic acid bacteria fermentation extract of honey. This reduces the water contact angle with the skin to which the composition according to this embodiment is applied, thereby improving skin compatibility.

[0043] Honey fermented with Lactobacillus extract is obtained by fermenting honey with Lactobacillus, and preferably by fermenting honey and chamomile flowers with Lactobacillus. The content of the honey lactic acid bacteria fermentation extract in the composition according to this embodiment may be, for example, 29% by weight.

[0044] Chamomile is a plant belonging to the family Asteraceae, and its scientific name is Matricaria chamomilla L. or Matricaria recutita L.

[0045] The chamomile flowers used for fermentation may be the flowers themselves, obtained by harvesting, or they may be processed chamomile flowers. Examples of processed chamomile flowers include those obtained by drying, grinding, or extracting chamomile flowers. These processing methods may be performed individually or in combination of two or more.

[0046] The processed chamomile flower product may be, for example, dried chamomile flower, pulverized chamomile flower, crushed chamomile flower, powder, extract, etc. The chamomile flower can be dried by, for example, sun drying, hot air drying, freeze drying, or spray drying. Pulverization and crushing can be performed using, for example, a pulverizer or crusher. The chamomile flower product is preferably dried chamomile flower powder. Dried chamomile flower powder can be obtained, for example, by drying the chamomile flower and then pulverizing it. It is preferable that the chamomile flower is dried and pulverized immediately after harvesting. Commercially available processed chamomile flower products can be used.

[0047] Chamomile flower extract can be obtained by extracting chamomile flowers using methods commonly used for plant extraction. For example, chamomile flowers, which are the raw material for extraction, are placed in a processing tank filled with an extraction solvent, and soluble components are eluted while stirring as needed. The extract can then be obtained by filtering to remove the extraction residue.

[0048] As the extract of chamomile flowers, the extract obtained by extracting chamomile flowers may be used as is, or it may be used after further processing such as dilution, concentration, drying, filtration, and purification.

[0049] The extraction solvent may be, for example, an aqueous solvent or a hydrophilic organic solvent. Examples of aqueous solvents include pure water, purified water, tap water, well water, mineral water, mineral water, hot spring water, spring water, fresh water, hot water, ion-exchanged water, physiological saline, phosphate buffer, and phosphate-buffered physiological saline. Examples of hydrophilic organic solvents include lower alcohols with 1 to 5 carbon atoms such as methanol, ethanol, propyl alcohol, and isopropyl alcohol; lower aliphatic ketones such as acetone and methyl ethyl ketone; and polyhydric alcohols with 2 to 5 carbon atoms such as 1,3-butylene glycol, propylene glycol, and glycerin. One of these extraction solvents may be used alone, or two or more may be used in combination.

[0050] The fermentation of honey, or honey and chamomile flowers, is carried out using lactobacilli. Examples of lactobacilli include bacteria belonging to the genus Lactobacillus, and more specifically, Lactobacillus kunkii is preferred.

[0051] Lactobacillus kunky is preferably assimilated to glucose and fructose, and more preferably to glucose, fructose, sucrose, trehalose, and gluconates. Lactobacillus kunky may also be Lactobacillus kunky BPS402. Lactobacillus kunky BPS402 was deposited on October 3, 2011, at the Patent Organism Depository Center of the National Institute of Advanced Industrial Science and Technology (1-1-1 Higashi, Tsukuba City, Ibaraki Prefecture, Japan (Postal Code 305-8566)) under accession number FERM P-22177 and is available. This strain has also been transferred to international depositary status under accession number FERM BP-11439.

[0052] The culture of Lactobacillus used for fermentation can be carried out according to conventional methods. There are no particular restrictions on the culture medium as long as it can be used to culture the bacteria, and natural media, synthetic media, semi-synthetic media, etc., can be used. The culture medium can contain a nitrogen source and a carbon source. Examples of nitrogen sources include meat extract, peptone, casein, yeast extract, gluten, soy flour, hydrolyzed soybeans, and amino acids, while examples of carbon sources include glucose, lactose, fructose, inositol, sorbitol, water, starch, koji juice, bran, bagasse, and molasses. In addition, inorganic substances (e.g., ammonium sulfate, potassium phosphate, magnesium chloride, sodium chloride, calcium carbonate, iron, manganese, molybdenum), various vitamins, etc., can be added.

[0053] The culture temperature may be, for example, 4 to 45°C, preferably 25 to 40°C, and more preferably 28 to 33°C. The culture time may be, for example, 8 to 72 hours. Culture may be carried out by aeration shaking or aeration stirring. The pH of the culture medium may be, for example, 4.0 to 9.0, and preferably 6.0 to 8.0. An example of a culture method is to inoculate bacterial cells into MRS medium and culture at 30°C for 48 hours.

[0054] The bacterial suspension obtained by culturing Lactobacillus can be used directly by sowing it into a fermentation medium containing honey, or a fermentation medium containing honey and chamomile flowers, for fermentation, or it can be diluted with a culture medium or other means before use.

[0055] Fermentation of honey by Lactobacillus, or fermentation of honey and chamomile flowers, can be carried out at, for example, 4 to 45°C, and preferably at 25 to 40°C. The fermentation time may be, for example, 12 to 60 hours, and preferably 24 to 48 hours. The pH of the honey-containing substance at the start of fermentation may be, for example, 3 to 8, and preferably 4 to 6. Fermentation may be carried out by aeration shaking or aeration stirring.

[0056] The fermentation of honey, or honey and chamomile flowers, can be carried out by culturing Lactobacillus in a fermentation medium containing honey, or honey and chamomile flowers. The fermentation medium containing honey, or honey and chamomile flowers, can be in any form that allows Lactobacillus to ferment, such as a liquid, paste, or gel. The fermentation medium may be a solution or suspension of honey, or honey and chamomile flowers, in a solvent such as water.

[0057] The honey concentration in the fermentation medium at the start of fermentation may be, for example, 0.1 to 40%, 1 to 30%, or 8 to 13% of the total volume of the fermentation medium. Furthermore, the honey concentration in the fermentation medium at the start of fermentation, as solid content, may be, for example, 0.08 to 32%, 0.8 to 24%, or 6.4 to 10.4% of the total volume of the fermentation medium.

[0058] The concentration of chamomile flowers in the fermentation medium at the start of fermentation may be, for example, 0.01-20%, 0.1-5%, or 0.5-2% of the total volume of the fermentation medium as solids. The mass ratio of honey (total volume) to chamomile flowers (dry mass) in the fermentation medium at the start of fermentation may be, for example, 4000:1-1:200, or 26:1-4:1. The fermentation medium may further contain known nutrients necessary for the cultivation of lactic acid bacteria, such as vitamins, amino acids, minerals, salts, surfactants, fatty acids, and metals. The honey used for fermentation may be sterilized by heating or other means.

[0059] The lactic acid bacteria fermentation extract of honey, or the lactic acid bacteria fermentation extract of honey and chamomile flowers, may be in its raw state obtained by fermentation, or it may have been subjected to treatments such as heating, filtration, purification, concentration, evaporation to dryness, freeze-drying, or spray-drying. The lactic acid bacteria fermentation extract of honey, or the lactic acid bacteria fermentation extract of honey and chamomile flowers, may contain live and / or dead Lactobacillus cells, or the cells may have been separated and removed by filtration or other means.

[0060] The composition according to this embodiment may be, for example, a cosmetic product or a cosmetic ingredient.

[0061] Cosmetic ingredients may be in any form, such as solid, liquid, or paste. Cosmetics may be medicated cosmetics (i.e., quasi-drugs). Cosmetics include all cosmetics that can be applied to the skin of animals (especially humans).

[0062] Cosmetics may contain honey, royal jelly, butylene glycol, pentylene glycol, lactic acid bacteria ferment extract of honey, or lactic acid bacteria ferment extract of honey and chamomile flowers, as well as other ingredients permitted in cosmetics. Examples of ingredients permitted in cosmetics include whitening agents, moisturizers, antioxidants, oily components, UV absorbers, surfactants, thickeners, alcohols, powder components, colorants, aqueous components, water, and various skin nutrients.

[0063] The dosage forms of cosmetics may be, for example, solubilized, emulsified, powdered, oil-based, geled, ointmented, aerosol, water-oil two-layer system, water-oil-powder three-layer system, etc. Examples of cosmetics include basic cosmetics such as facial cleansers, lotions, emulsions, creams, gels, essences, serums, packs, masks, mists, and UV protection cosmetics, as well as foundations, lipsticks, blushes, eyeshadows, etc. a Makeup cosmetics such as eyeliner and mascara ,Ma This may include massage agents, cleansing agents, aftershave lotions, pre-shave lotions, shaving creams, body soaps, soaps, hand creams, hand soaps, etc.

[0064] The composition according to this embodiment is particularly suitable for use as a booster serum (pre-serum) or as an ingredient therein. A booster serum is one that improves the skin absorption of cosmetics such as lotions and emulsions that are applied after the booster serum. Since the composition according to this embodiment improves skin absorption, it can be suitably used in cosmetics for such purposes.

[0065] The dosage of the composition according to this embodiment when administered parenterally may be once a day, or divided into multiple doses, such as twice or three times a day. The dosage may vary depending on the health condition of the subject, the combination with other compositions, or the site and extent of application, and can be arbitrarily set by those skilled in the art as needed. For example, the application dose when administered to the skin in a single dose may be 0.001 to 10 mg / cm³. 2 It may be 0.001-8 mg / cm³. 2 Preferably, 0.001 to 6 mg / cm³ 2 This is preferable.

[0066] The method for producing the composition according to this embodiment is not particularly limited and can be carried out according to any known method. For example, a composition for the above purpose can be obtained by mixing honey, or optionally royal jelly, butylene glycol, pentylene glycol, or a lactic acid bacteria fermentation extract of honey, with an intermediate or final product in the manufacturing process of cosmetics.

[0067] [Methods to improve skin absorption] A method for improving skin compatibility according to one embodiment includes applying the above-mentioned honey to the skin. By applying the above-mentioned honey, skin compatibility is improved compared to when the honey is not applied to the skin. The method for improving skin compatibility may further include applying the above-mentioned royal jelly, the above-mentioned butylene glycol, and the above-mentioned pentylene glycol to the skin. Furthermore, the method for improving skin compatibility may further include applying the above-mentioned lactic acid bacteria fermentation extract of the honey. [Examples]

[0068] The present invention will be described more specifically below based on examples. However, the present invention is not limited to the following examples.

[0069] [Example of test: Evaluation of skin-friendly effect by measuring the contact angle of water] Following the procedure outlined below, the contact angle of water with the skin to which each sample shown in Table 1 was applied was measured, and the effect on improving skin compatibility was evaluated.

[0070] Samples 1-5 shown in Table 1, each weighing 0.1 g, were applied to a 5 cm x 5 cm area on a BioSkin plate (Burelux Corporation), and each sample was allowed to dry for at least one hour. Next, 2 μl of water was dropped onto each sample area, and the water contact angle was measured after 1000 milliseconds using the droplet method. The water contact angle was measured using an automatic contact angle meter DMo-602 (Kyowa Interface Science Co., Ltd.) and analyzed using the θ / 2 method. The results are shown in Table 2.

[0071] [Table 1]

[0072] [Table 2]

[0073] In the untreated case, the water contact angle to the skin was 92 degrees. On the other hand, after applying samples 1 and 2, the water contact angle to the skin was 30 degrees or less. This suggests that applying honey to the skin improves subsequent absorption. Furthermore, the water contact angle to the skin after applying sample 5 was even smaller than that of samples 1 and 2. This suggests that applying royal jelly, butylene glycol, pentylene glycol, and a lactic acid bacillus ferment extract of honey and chamomile flowers to the skin, in addition to honey, further improves skin absorption.

Claims

1. A booster composition for improving skin compatibility, comprising honey, royal jelly, butylene glycol, pentylene glycol, and a lactic acid bacillus ferment extract of honey, wherein the water contact angle with the skin to which the composition is applied is 14 degrees or less.

2. The composition according to claim 1, wherein the honey is manuka honey and / or acacia honey.

3. A method for producing the composition according to claim 1 or 2, comprising the step of fermenting honey and chamomile flowers using Lactobacillus kunkii to obtain a lactic acid bacillus fermented extract of the honey.

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