Magnetic resonance imaging drugs containing deuterated sarcosine and diagnostic methods using these drugs

Deuterated sarcosine derivatives provide accurate diagnostic imaging by selectively accumulating in tissues, addressing the limitations of current MRI methods in distinguishing tumors and assessing metabolic activity, improving diagnostic reliability and safety.

JP7893605B2Inactive Publication Date: 2026-07-22SOLVEX LLC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
SOLVEX LLC
Filing Date
2019-05-08
Publication Date
2026-07-22
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Current MRI methods struggle to reliably distinguish between malignant tumors and benign formations, leading to high false positive rates, and there is a need for more effective diagnostic agents that can provide clear data on nutrient absorption levels and metabolic activity in diseases.

Method used

Development of diagnostic agents containing deuterated sarcosine derivatives and pharmaceutically acceptable salts, which selectively accumulate in target tissues, allowing for magnetic resonance imaging and spectroscopy to assess nutrient absorption levels and metabolic activity, providing deuterium tomography and NMR spectra.

Benefits of technology

Enables accurate diagnosis of diseases by detecting localized changes in nutrient absorption, assessing tumor malignancy, and evaluating metabolic activity without ionizing radiation, enhancing diagnostic reliability and safety.

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Abstract

The present invention relates to a means for magnetic resonance imaging of tumor diseases and other diseases accompanied by local changes in cellular nutrient absorption levels. The present invention relates to a diagnostic agent comprising at least one deuterated derivative of sarcosine, as well as a diagnostic method based on the use of this diagnostic agent. The method of the present invention comprises administering the diagnostic agent within a time sufficient for the diagnostic agent to accumulate in a target region of the subject's body, followed by magnetic resonance imaging and / or deuterium magnetic resonance spectroscopy. The proposed method makes it possible to perform highly informative diagnoses of tumor diseases and other diseases accompanied by local changes in cellular nutrient absorption levels.
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