Intestinal oxygenation therapy

Intestinal oxygenation therapy using oxygen carriers and prodrugs converts the intestinal environment to an aerobic state, effectively inhibiting anaerobic bacterial growth and reducing toxicity, addressing the inefficiencies of existing treatments.

JP7893747B2Active Publication Date: 2026-07-22LPOXY THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
LPOXY THERAPEUTICS INC
Filing Date
2021-03-31
Publication Date
2026-07-22

AI Technical Summary

Technical Problem

Existing treatments for intestinal anaerobic infections, such as hyperbaric oxygen therapy, are inefficient, inaccessible, and pose risks due to narrow therapeutic indices, and do not effectively convert the anaerobic intestinal environment to an aerobic one.

Method used

Intestinal oxygenation therapy (EAT) using oxygen carrier molecules, oxygen-containing mixtures, oxygen prodrugs, and oxygen-evolving compounds to deliver oxygen to the intestinal tract, creating an aerobic environment that inhibits anaerobic bacterial growth and reduces toxicity.

Benefits of technology

EAT effectively converts the intestinal environment to an aerobic state, inhibiting anaerobic bacterial growth and reducing toxicity, providing a safe and accessible treatment for infections like Clostridioides difficile, foodborne illnesses, and inflammatory bowel disease.

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Abstract

Agents, kits, and methods are provided that utilize oxygenation to prevent and / or treat infections caused by anaerobic microorganisms. The agents, kits, and methods, according to some embodiments, utilize oxygenation in the intestinal lumen to prevent and / or treat infections caused by anaerobic bacteria. The agents, kits, and methods can be used to prevent and / or treat anaerobic infections in the intestinal lumen through intestinal oxygenation therapy.
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