Topical skin preparations

Abstract

To provide a topical skin preparation that utilizes a specific combination of components, which synergistically enhances the viscoelasticity and glossiness of the skin.SOLUTION: A topical skin preparation comprises the following (A)-(D): (A) diglycerol, (B) polyglycerol, (C) Tremella fuciformis extract and (D) biosaccharide gum.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a topical skin preparation.

Background Art

[0002] Human skin develops wrinkles, sagging, and a loss of luster due to external stresses such as aging and ultraviolet rays. To improve such symptoms, technical developments such as combining various components have been carried out (Patent Documents 1 and 2). However, simply combining them does not result in a synergistic improvement in the effect. The effect of such combination is an unpredictable effect, such as an additive improvement in the effect or an effect cancellation. Among them, there is a very high need to incorporate components that can achieve a higher effect with a smaller amount into topical skin preparations.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0004] An object of the present invention is to provide a topical skin preparation that synergistically improves the viscoelasticity and gloss of the skin by combining specific components.

Means for Solving the Problems

[0005] Means for solving the problems of the present invention is to provide a topical skin preparation containing the following (A) to (D). (A) Diglycerin (B) Polyglycerin ' (C) Jellyfish extract (D) Biosaccharide gum [Effects of the Invention]

[0006] This invention, by using a combination of specific ingredients, exhibits a synergistic effect in improving the viscoelasticity and radiance of the skin. [Modes for carrying out the invention]

[0007] The following describes embodiments for carrying out the present invention.

[0008] [Diglycerin] The diglycerin incorporated into the topical skin preparation of the present invention is not particularly limited in its raw materials, manufacturing method, purification method, etc., as long as it is a type commonly used in topical skin preparations. Examples of commercially available products include Diglycerin S (manufactured by Sakamoto Pharmaceutical Co., Ltd.) and Uniglycerin G-2 (manufactured by NOF Corporation).

[0009] The amount of diglycerin used in the present invention is not particularly limited, but is preferably 0.01 to 20% by mass, and more preferably 0.1 to 20% by mass, relative to the total amount of the topical skin preparation.

[0010] [Polyglycerin] The polyglycerin incorporated into the topical skin preparation of the present invention is not particularly limited as long as it is commonly used in topical skin preparations, etc., but examples include diglycerin, triglycerin, tetraglycerin, pentaglicerin, hexaglycerin, heptaglicerin, octaglycerin, nonaglycerin, decaglycerin, hexadecaglycerin, octadecaglycerin, eicosadecaglycerin, etc. Among these, triglycerin, tetraglycerin, pentaglicerin, hexaglycerin, heptaglicerin, octaglycerin, nonaglycerin, and decaglycerin are preferred. More preferably, it is triglycerin. Commercially available products such as PGL-S, polyglycerin #310, polyglycerin #500, and polyglycerin #750 (all from Sakamoto Pharmaceutical Co., Ltd.) can also be used.

[0011] The amount of polyglycerin used in the present invention is not particularly limited, but is preferably 0.1 to 20% by mass, and more preferably 0.1 to 10% by mass, relative to the total amount of the topical skin preparation.

[0012] [White Jelly Mushroom Extract] The Tremella fuciformis extract incorporated into the topical skin preparation of the present invention is a water-soluble polysaccharide extracted using a solvent from a mushroom belonging to the family Tremellaceae.

[0013] Suitable extraction solvents include water, lower alcohols such as ethanol, and polyhydric alcohols such as 1,3-butylene glycol and dipropylene glycol. These solvents may be used individually or in mixtures of two or more. Among these, water, hot water, or a solvent that can be mixed with water in any proportion, such as a mixture of ethanol and 1,3-butylene glycol, is preferred, and hot water is more preferred. The extraction method is not particularly limited, but one example is a method in which the solvent for extraction is mixed with Tremella fuciformis and heated for extraction. The obtained extract can be used as is, or it can be concentrated as appropriate or dried into a powder by spray drying or freeze-drying.

[0014] In addition, commercially available products such as Tremoist-TP, Tremoist-SL (both manufactured by Nippon Seika Co., Ltd.), White Jelly Mushroom Polysaccharide-P (manufactured by Oryza Oil & Fat Chemical Co., Ltd.), and HyaCareTremella (manufactured by Evonik Japan Co., Ltd.) can also be used.

[0015] The amount of Tremella fuciformis extract used in the present invention is not particularly limited in relation to the total amount of topical skin preparation, but is preferably 0.000001 to 3% by mass, and more preferably 0.00001 to 2% by mass, as the pure content of Tremella fuciformis extract.

[0016] [Biosaccharide Gum] The biosaccharide gums incorporated into the topical skin preparation of the present invention include biosaccharide gums-1, 2, 3, and 4, all of which are obtained from sorbitol by fermentation, but the manufacturing method is not particularly limited. Biosaccharide gum-1 is a polysaccharide in which L-fucose, D-galactose, and D-galacturonic acid are continuously linked. Biosaccharide gum-2 is a polysaccharide mainly composed of rhamnose, and is a polymer of α-L-Rhap(1→3)-β-D-Galp-(1→2)―α―LRhap(1→4)―β―D-Glep-(1→3)-[α-L-Rhap-(1→2)-]―α―D-Galp-(1). Biosaccharide gum-3 is a polysaccharide in which L-fucose, D-galactose, and D-galacturonic acid are continuously linked, but it is a polysaccharide with a smaller degree of polymerization and molecular weight than biosaccharide gum-1. Biosaccharide gum-4 is a deacetylated branched polysaccharide with L-fucose, 2-D-glucose, and glucuronic acid as repeating units. Among these, biosaccharide gum-1 is preferably used in the topical skin preparation of the present invention.

[0017] The topical skin preparation of the present invention may use commercially available products and is not particularly limited, but for example, FUCOGEL 1.5P and FUCOGEL 1000 PP, which are biosaccharide gum-1; Rhamnosoft HP 1.5P, which is biosaccharide gum-2; and Glicofilm 1.5P, which is biosaccharide gum-4 (all manufactured by Solavia, France) can be used.

[0018] The amount of biosaccharide gum included in the present invention is not particularly limited in relation to the total amount of the topical skin preparation, but it is preferably 0.0000001 to 1% by mass as the pure biosaccharide gum content.

[0019] The external preparation for skin of the present invention can adjust its viscosity by blending a water-soluble polymer. Such a water-soluble polymer is not particularly limited, but it is preferable to use one or more selected from acrylic acid-based water-soluble polymers and gum-based water-soluble polymers. Examples of such acrylic acid-based water-soluble polymers and gum-based water-soluble polymers include polyacrylic acid and its salts, carbomers, (acrylates / acrylic acid alkyl (C10-30)) cross-polymers, acrylamide / acrylamide-2-methylpropanesulfonate copolymer, hydroxyethyl acrylate / acryloyl dimethyl taurine copolymer, acrylate / acryloyl dimethyl taurine copolymer, acrylamide / acrylic acid-2-methylpropanesulfonate copolymer, acryloyldimethyltaurine salt / vinylpyrrolidone copolymer, etc. Among these, acrylate / acryloyl dimethyl taurine copolymer, acrylamide / acrylic acid-2-methylpropanesulfonate copolymer, acryloyldimethyltaurine salt / vinylpyrrolidone copolymer, gum arabic, tragacanth gum, guar gum, gellan gum, cyam gum, carob gum, karaya gum, xanthan gum, etc. are mentioned. In the present invention, for the purpose of improving the usability such as firmness and elasticity, moist feeling, etc., it is preferable to use an acrylic acid-based water-soluble polymer and a gum-based water-soluble polymer in combination, and it is most preferable to use carbomer and xanthan gum in combination. When blending the water-soluble polymer, the blending amount is preferably 0.0001 to 1% by mass as the total amount of the water-soluble polymer with respect to the total amount of the external preparation for skin.

[0020] In addition to the above-mentioned components, the external preparation for skin of the present invention can contain optional components usually used in ordinary cosmetics and quasi-drugs, as long as the effects of the present invention are not inhibited. Specifically, oil agents, surfactants, thickeners, preservatives, fragrances, humectants, antioxidants, anti-inflammatory agents, antibacterial agents, etc. can be mentioned.

[0021] The dosage form of the external preparation for skin of the present invention is not particularly limited, and it may be any dosage form such as aqueous type, emulsion type, etc.

[0022] The external preparation for skin of the present invention can be prepared by a conventional method.

[0023] The topical skin preparation of the present invention can be used in the form of, for example, a lotion, emulsion, or ointment. [Examples]

[0024] The present invention will be specifically described below with reference to examples, but this will not limit the scope of the present invention. Unless otherwise specified, the amounts are given in mass percent.

[0025] [Test Method] The samples shown in Table 1 were prepared, and their viscoelasticity and gloss were measured.

[0026] [Method for measuring viscoelasticity (R1 value)] (1) Acclimation After washing the inner side of both forearms, the subjects dried them and rested for 15 minutes in a room adjusted to a temperature of 21±0.5℃ and humidity of 50±5% to allow for acclimatization. (2) Application A 2cm x 2cm area was marked on the inner side of both forearms, 4 μL of the solution was dropped onto the area using a pipette, and then evenly spread with a finger wearing a finger cot. (3) Measurement Viscoelasticity was measured twice in each region using a Cutometer MPA580 before application and 30 minutes after application. Skin viscoelasticity was measured using a probe with a 2 mm suction port, applying suction at a pressure of 150 mb for 1 second, and then analyzing the displacement of the skin upon release. In this study, the parameter (R1) used as an index of skin viscoelasticity was analyzed. This value indicates "how much the skin returns to its original state after being suctioned for a certain period of time," and the lower the viscoelasticity, the worse the skin returns and the larger the value. Relative values ​​were calculated with the pre-application value set to 1 and are shown in Table 1.

[0027] [Method for measuring glossiness (shine level)] (1) Acclimation After washing the inner side of both forearms, the subjects dried them and rested for 15 minutes in a room adjusted to a temperature of 21±0.5℃ and humidity of 50±5% to allow for acclimatization. (2) Application A 2cm x 2cm area was marked on the inner side of both forearms, 4 μL of the solution was dropped onto the area using a pipette, and then evenly spread with a finger wearing a finger cot. (3) Measurement The gloss level (amount of light directly reflected from the skin surface = Gloss Value) was measured five times in each area using a Glossymeter GL200 before application, 15 minutes after application, and 30 minutes after application. A higher gloss value indicates a higher level of gloss. Relative values ​​were calculated with the pre-application value set to 0 and are shown in Table 1.

[0028] [Table 1]

[0029] As shown in Table 1, compared to Comparative Examples 1-4, in which each component was applied individually, Example 1 showed improved viscoelasticity and gloss despite using only one-quarter the amount of each component compared to the Comparative Examples. This indicates that the topical skin preparation of the present invention exhibits a synergistic effect in improving viscoelasticity and gloss when diglycerin, polyglycerin, Tremella fuciformis extract, and biosaccharide gum are used in combination.

[0030] [Example 2] Serum (1) Purified water, remainder (mass %) (2) Diglycerin 2.0 (3) Polyglycerin-3 2.0 (4) Tremella fuciformis extract (Note 1) 2.0 (5) Biosaccharide gum-1 (Note 2) 2.0 (6) Glycerin 5.0 (7) 1,3-Butylene glycol 10.0 (8) Propanediol 5.0 (9) Xanthan gum 0.01 (10) Carbomer 0.01

[0031] In Example 2, the material also exhibited excellent viscoelasticity and gloss.

Claims

[Claim 1] A topical skin preparation containing the following (A) to (D). (A) Diglycerin (B) Triglycerin (C) Tremella fuciformis extract (D) Biosaccharide gum

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