Agitator and stirring apparatus equipped therewith

Abstract

Provided is a stirring body that generates a plurality of flows including a circulating flow, a turbulent flow, and the like to stir a fluid medium in a complexly unsteady manner, enables adjustment of the flow of a stirring flow to match the purpose, exhibits low shear, and can be simply manufactured.　The stirring body is characterized by comprising a flat plate in which a plurality of spiral blade sections extending from a central section are formed by the incision of spiral shapes that do not adjoin an outer peripheral section, and an actuation member that supports the flat plate, wherein one of the actuation member and the outer peripheral section of the flat plate can move in a direction of relative separation and a direction of relative approach to the other, and in coordination with movement in the direction of relative separation, the blade sections rise while separating from the neighboring blade sections and the flat plate extends, thereby forming a three-dimensional shape.

Description

Technical Field

[0001] The present invention relates to a stirring blade and a stirring device including the same.

Background Art

[0002] Conventionally, as a culture method for platelet production in the medical field, there is static culture in a culture dish. However, with the production method by static culture, it has been difficult to produce a large amount of inactive platelets required for transfusion. Therefore, platelet production in vitro using newly developed human iPS cells has attracted attention. The key to this platelet production is unsteady stirring that generates turbulent flow, aiming to realize a new production system for platelet preparations and blood preparations that do not depend on donors, and there is a strong demand for the development of a three-dimensional suspension stirring culture device that can produce a large amount of high-quality inactive platelets.

[0003] Regarding the manufacturing method of platelet preparations and blood preparations, as described in Patent Document 1, there is a stirring culture device in which stirring blades having a shape such as a disk, an ellipse, or a rectangle reciprocate vertically to unsteadily stir the culture solution. In this manufacturing method, by generating turbulent flow due to the vertical movement of the stirring blade and unsteadily stirring the culture solution, while three-dimensionally suspending and culturing megakaryocyte cells, which are the largest cells present in the bone marrow in vivo, in the culture solution, it is said that the production efficiency and physiological activity of platelets differentiated and released from human iPS cell-derived megakaryocyte cells can be increased, the deterioration of platelets can be suppressed at a low level, and abnormal platelets can be reduced.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] As mentioned above, conventional reciprocating stirring culture devices used for platelet production and other applications only generate simple flow through transient stirring by stirring blades. There were no reciprocating stirring culture devices that generated multiple flows and performed complex transient stirring by simply reciprocating the stirring blades up and down, causing the blades to deform and exhibit dynamic behavior.

[0006] Furthermore, in addition to stirring by moving the stirring blades of the stirring device up and down in the normal direction, if stirring is to be performed with multiple operating directions involving forward and reverse rotation of the stirring blades, for example, multiple drive devices that drive in different operating directions or a complex mechanism that allows a single drive device to operate in multiple operating directions would be required, which presented problems in terms of the durability and cost of the drive devices.

[0007] Furthermore, while conventional reciprocating stirring culture devices could adjust the flow velocity of the stirred flow by controlling the reciprocating speed of the stirring blades, changing the flow pattern of the stirred flow required replacing the stirring blades with blades of different shapes each time. There were no stirring blades that could adjust the flow of the stirred flow by simply controlling the reciprocating distance of a single stirring blade, causing the blade to dynamically behave through elastic deformation and appropriately form multiple deformation patterns.

[0008] Therefore, the present invention aims to provide a low-shear, easily manufactured agitator and an agitator equipped with the same, which, in order to solve the problems of the prior art, allows for extremely complex, unsteady agitation of a fluid medium by having multiple operating directions, generating complex circulating flows and turbulence accompanied by vortices, simply by reciprocating the agitator blades, causing the agitator blades to undergo dynamic behavior through elastic or plastic deformation to form multiple different deformation forms, and furthermore, by controlling the reciprocating distance of the agitator blades to form multiple different deformation forms, the flow of the agitated flow can be easily adjusted according to the purpose. [Means for solving the problem]

[0009] The stirring body of the present invention comprises a flat plate having a plurality of spiral-shaped blades extending from the center by spiral-shaped cuts that do not contact the outer circumference, and an operating member that supports the flat plate, wherein either the operating member or the outer circumference of the flat plate is movable in a direction that moves away from each other and in a direction that moves towards each other, and in conjunction with the movement in the direction that moves away from each other, the blades stand up while moving away from adjacent blades, and the flat plate extends to form a three-dimensional shape.

[0010] In the stirring device of the present invention, the operating member is characterized in that it supports the flat plate in a fixed state relative to the flat plate. Furthermore, the operating member is characterized in that it supports the flat plate in a rotatable manner relative to the flat plate. Furthermore, the operating member or the flat plate is characterized in that it can rotate in both forward and reverse directions during the movement. Furthermore, the three-dimensional shape formed by the elongation of the flat plate is characterized by the formation of one or more constricted sections. Furthermore, in the three-dimensional shape formed by the elongation of the flat plate, the wing portion is characterized by being formed in a plurality of wave-like shapes in which the front and back surfaces are exposed when viewed from one direction. Furthermore, the notches are characterized by being formed by connecting arcs, straight lines, or combinations thereof in series.

[0011] The stirring device of the present invention is characterized by comprising the stirring body described above and a drive device for moving the operating member or the flat plate.

[0012] In the stirring apparatus of the present invention, the drive device is characterized in that, in addition to the movement, it rotates the operating member or the flat plate. [Effects of the Invention]

[0013] According to the present invention, it is possible to create a low-shear, easily manufactured agitator and an agitator equipped therewith that can generate multiple flow types, including circulating flow and turbulent flow, to complexly and non-steady-state agitate a fluid medium and adjust the flow of the agitated flow according to the purpose. [Brief explanation of the drawing]

[0014] [Figure 1] This diagram shows a first embodiment of the stirring body according to the present invention, where (A) is a plan view showing the stirring body having a two-dimensional shape, (B) is a cross-sectional view showing the stirring body along line 1A-1A in (A), and (C) is a perspective view showing the stirring body having the two-dimensional shape of (A). [Figure 2] (A) is a side view of the stirring body when it is extended from the two-dimensional shape shown in Figure 1 to a three-dimensional shape, (B) is a perspective view showing the three-dimensional shape of (A), and (C) is a top view showing the three-dimensional shape of (A). [Figure 3] (A) is a side view showing the stirring body further extended from the one shown in Figure 2, (B) is a perspective view showing the three-dimensional shape of (A), and (C) is a top view showing the three-dimensional shape of (A). [Figure 4] This diagram shows a first embodiment of a stirring device equipped with a stirring element according to the present invention, where (A) is a side view showing the stirring device equipped with a stirring element, (B) is a schematic diagram showing the movement of fluid by the stirring device in (A), and (C) is a cross-sectional view showing the stirring device along line IVA-IVA in (A). [Figure 5] The second embodiment of a stirring device equipped with a stirring element according to the present invention is shown, where (A) is a side view showing the stirring device equipped with a stirring element according to the present invention, (B) is a top view showing the stirring device of (A), and (C) is a cross-sectional view showing the stirring device of (A) along the dashed line VA-VA. [Figure 6]The following are examples of embodiments of the stirring body according to the present invention, with (A) being a side view illustrating a stirring body in which one set of flat plates is enclosed inside another set of flat plates, (B) being a top view of the stirring body illustrated in (A), (C) being a side view illustrating a stirring body in which a support member is connected to the center of the flat plates, (D) being a top view of the stirring body illustrated in (C), (E) being a side view illustrating a stirring body in which a support member is connected to the outer circumference of the flat plates, and (F) being a top view of the stirring body illustrated in (E). [Figure 7] (A) is a side view showing a stirring body in which two flat plates are joined at their outer edges, (B) is a top view of the stirring body shown in (A), (C) is a side view showing a stirring body in which two flat plates are joined at their centers, (D) is a top view of the stirring body shown in (C), and (E) is a bottom view of the stirring body shown in (C). [Figure 8] The following are examples of various forms of the flat plate of the stirring body according to the present invention: (A) is a top view and perspective view illustrating a flat plate with a flat plate auxiliary member joined to the central side; (B) is a top view and perspective view illustrating a flat plate with a flat plate auxiliary member joined to the outer peripheral side; and (C) is a top view and perspective view illustrating a flat plate with a flat plate auxiliary member joined to both the central and outer peripheral sides. [Figure 9] The diagram illustrates various embodiments of the stirring body's flat plate with different notches: (A) is a plan view illustrating a circular flat plate with a wave-like shape and spiral-shaped cutouts; (B) is a plan view illustrating a flat plate with cutouts along the outer shape of a square; (C) is a plan view illustrating a regular hexagonal flat plate with spiral-shaped cutouts and flaps extending in the left-right direction; and (D) is a plan view illustrating an elliptical flat plate with multiple through holes. [Figure 10] The second embodiment of the stirring body according to the present invention is shown, where (A) is a top view showing the case when it has a two-dimensional shape, (B) is a cross-sectional view showing the stirring body along the dashed line IA-IA in (A), and (C) is a bottom view showing the case when it has the two-dimensional shape of (A). [Figure 11](A) shows a side view of the stirring body when extended from the two-dimensional shape shown in FIG. 10 to a three-dimensional shape, (B) shows a perspective view when having the three-dimensional shape of (A), and (C) shows a top view when having the three-dimensional shape of (A). [Figure 12] (A) shows a side view when the stirring body shown in FIG. 11 is further extended, (B) shows a perspective view when having the three-dimensional shape of (A), and (C) shows a top view when having the three-dimensional shape of (A). [Figure 13] (A) shows a side view when the central part of the stirring body shown in FIG. 12 is twisted, (B) shows a perspective view when having the three-dimensional shape of (A), and (C) shows a top view when having the three-dimensional shape of (A). [Figure 14] The third embodiment of the stirring device provided with the stirring body according to the present invention is shown. (A) shows a side view of the stirring device provided with the stirring body, (B) shows a cross-sectional view of the stirring device along the dashed line VA1-VA1 of (A), (C) shows a cross-sectional view of the stirring device along the dashed line VA2-VA2 of (A), and (D) is a schematic diagram showing the movement of the fluid by the stirring device of (A). [Figure 15] The fourth embodiment of the stirring device provided with the stirring body according to the present invention is shown. (A) is a schematic diagram showing the movement of the fluid by the stirring device provided with the stirring body, and (B) is a cross-sectional view of the stirring device along the dashed line VIA-VIA of (A). [Figure 16] (A) is a schematic diagram showing the movement of the fluid by the stirring device provided with the stirring body, and (B) is a cross-sectional view of the stirring device along the dashed line VIIA-VIIA of (A). [Figure 17] The fifth embodiment of the stirring device provided with the stirring body according to the present invention is exemplified. (A) is a schematic diagram exemplifying the movement of the fluid by the stirring device provided with the stirring body, and (B) is a cross-sectional view exemplifying the stirring device along the dashed line VIIIA-VIIIA of (A). [Figure 18]A sixth embodiment of the stirring device equipped with a stirring element according to the present invention is illustrated, where (A) is a side view illustrating the stirring device equipped with a stirring element, and (B) is a cross-sectional view illustrating the stirring device along the dashed line IXA-IXA in (A). [Figure 19] A seventh embodiment of the stirring device equipped with a stirring element according to the present invention is illustrated, where (A) is a schematic diagram illustrating the movement of a fluid in the stirring device equipped with a stirring element, and (B) is a cross-sectional view illustrating the stirring device along the dashed line XA-XA in (A). [Figure 20] The eighth embodiment of a stirring device equipped with the stirring element according to the present invention is illustrated, where (A) is a plan view illustrating the flat plate of the stirring element according to the present invention, (B) is a side view illustrating the stirring device equipped with the stirring element of (A), (C) is a cross-sectional view illustrating the stirring device along the dashed line XIB1-XIB1 of (B), and (D) is a cross-sectional view illustrating the stirring device along the dashed line XIB2-XIB2 of (B). [Figure 21] A ninth embodiment of a stirring device equipped with a stirring element according to the present invention is illustrated, where (A) is a side view illustrating a stirring device equipped with a stirring element according to the present invention, (B) is a top view illustrating the stirring device of (A), and (C) is a cross-sectional view illustrating the stirring device along the dashed line XIIA-XIIA of (A). [Figure 22] The diagram illustrates various embodiments of the stirring body with different configurations of the flat plates according to the present invention. (A) is a side view illustrating a stirring body in which two flat plates are arranged in a vertical column, and (B) is a side view illustrating a stirring body in which two flat plates are arranged in a vertical column with their outer edges adjacent to each other. [Figure 23] (A) is a side view illustrating a stirring body in which two flat plates are joined at their centers, (B) is a side view illustrating a stirring body in which two different flat plates are joined at their outer edges, and (C) is a side view illustrating a stirring body in which one set of flat plates contains another set of different plates inside. [Figure 24](A) is a side view illustrating a stirring body in which a U-shaped movable member is joined to the outer periphery of a flat plate; (B) is a top view of the stirring body illustrated in (A); (C) is a side view illustrating a stirring body in which a flat plate is fixed to a guide member having three branching sections; (D) is a top view of the stirring body illustrated in (C); (E) is a side view illustrating a stirring body in which two flat plates adjacent to each other at their outer peripheries are fixed to a guide member having a rectangular frame; and (F) is a top view of the stirring body illustrated in (E). [Figure 25] The following are examples of various forms of the flat plate of the stirring body according to the present invention: (A) is a top view and perspective view illustrating a flat plate to which a flat plate auxiliary member is joined on the outer circumference side, and (B) is a top view and perspective view illustrating a flat plate to which a ring-shaped flat plate auxiliary member is joined on the outer circumference side. [Figure 26] The diagram illustrates various embodiments of the stirring body's flat plate with different notches: (A) is a plan view illustrating a circular flat plate with a wave-like shape and spiral-shaped cutouts; (B) is a plan view illustrating a flat plate with cutouts along the outer shape of a square; (C) is a plan view illustrating a regular hexagonal flat plate with spiral-shaped cutouts and flaps extending in the left-right direction; and (D) is a plan view illustrating an elliptical flat plate with multiple through holes. [Figure 27] This diagram shows a third embodiment of the stirring body according to the present invention, where (A) is a plan view showing the stirring body having a two-dimensional shape, (B) is a cross-sectional view showing the stirring body along the dashed line IA-IA in (A), and (C) is a perspective view showing the stirring body having the two-dimensional shape of (A). [Figure 28] (A) is a side view of the stirring body when it is extended from the two-dimensional shape shown in Figure 27 to a three-dimensional shape, (B) is a perspective view showing the three-dimensional shape of (A), and (C) is a top view showing the three-dimensional shape of (A). [Figure 29] (A) is a side view showing the stirring body further extended from the one shown in Figure 28, (B) is a perspective view showing the three-dimensional shape of (A), and (C) is a top view showing the three-dimensional shape of (A). [Figure 30] (A) is a side view showing the stirring body shown in Figure 29 with its center twisted, (B) is a perspective view showing the three-dimensional shape of (A), and (C) is a top view showing the three-dimensional shape of (A). [Figure 31] The diagram shows a tenth embodiment of a stirring device equipped with a stirring element according to the present invention, where (A) is a side view showing the stirring device equipped with a stirring element, (B) is a cross-sectional view showing the stirring device along the dashed line VA-VA in (A), and (C) is a schematic diagram showing the movement of the fluid by the stirring device in (A). [Figure 32] This diagram shows an eleventh embodiment of a stirring device equipped with a stirring element according to the present invention, where (A) is a schematic diagram showing the movement of fluid by another stirring device equipped with a stirring element, and (B) is a cross-sectional view showing the stirring device along the dashed line VIA-VIA in (A). [Figure 33] (A) is a schematic diagram showing the movement of a fluid by a stirring device equipped with a stirring element, and (B) is a cross-sectional view showing the stirring device along the dashed line VIIA-VIIA in (A). [Figure 34] The twelfth embodiment of the stirring device equipped with a stirring element according to the present invention is illustrated, where (A) is a schematic diagram illustrating the movement of fluid by the stirring device equipped with a stirring element, (B) is a cross-sectional view illustrating the stirring device along the dashed line VIIIA1-VIIIA1 in (A), and (C) is a cross-sectional view illustrating the stirring device along the dashed line VIIIA2-VIIIA2 in (A). [Figure 35] The fourth embodiment of the stirring body according to the present invention illustrates an example of a stirring blade, where (A) is a side view illustrating a stirring blade in which two stirring bodies are arranged in a vertical row, and (B) is a side view illustrating a stirring blade comprising a stirring body in which two flat plates are joined at their outer edges. [Figure 36] (A) is a side view illustrating a stirring blade having an agitator in which two planar plates are joined at their centers, (B) is a side view illustrating a stirring blade having an agitator in which two different planar plates are joined at their outer edges, and (C) is a side view illustrating a stirring blade having an agitator in which one set of planar plates contains another set of different plates inside one set. [Figure 37] The diagram illustrates various embodiments of the stirring plate according to the present invention, with (A) being a plan view illustrating a circular stirring plate with a wave-shaped cutout, (B) being a plan view illustrating a stirring plate with a cutout along the outer shape of a square, (C) being a plan view illustrating a regular hexagonal stirring plate with a spiral-shaped cutout and flap extending in the left-right direction, and (D) being a plan view illustrating an elliptical stirring plate with a plurality of through holes. [Figure 38] The thirteenth embodiment of a stirring device equipped with a stirring element according to the present invention is illustrated, where (A) is a conceptual cross-sectional view illustrating a mixer equipped with a stirring element in which two planar plates are joined at their centers, and (B) is a front view of the mixer of (A). [Figure 39] A 14th embodiment of a stirring device equipped with a stirring element according to the present invention is illustrated, where (A) is a cross-sectional view of the stirring device and (B) is a plan view. [Modes for carrying out the invention]

[0015] The stirring body of the present invention comprises a flat plate on which a plurality of spiral-shaped blades extending from the center are formed by spiral-shaped cuts that do not contact the outer circumference, and an operating member that supports the center of the flat plate and is capable of moving away from the flat plate, characterized in that, in conjunction with the movement of the operating member away from the flat plate, the blades rise up while separating from adjacent blades, causing the flat plate to extend and form a three-dimensional shape.

[0016] In the first embodiment described later, the working member of the stirring body corresponds to a support member that supports one of the outer periphery and the central part of the flat plate, and a movable member that supports the other of the outer periphery and the central part, and is capable of reciprocating relative to the support member in a direction that brings the outer periphery and the central part closer to and further apart from each other. Furthermore, in the second embodiment described later, the operating member corresponds to a guide member and a movable member connected to either the central part or the outer periphery of the flat plate and capable of rotating and moving along the guide member. Furthermore, in the third and fourth embodiments described later, the operating member corresponds to a shaft member.

[0017] Hereinafter, embodiments of the stirring body and stirring apparatus equipped therewith according to the present invention will be described with reference to the drawings.

[0018] (First embodiment of the stirring device) In the stirring bodies 1A, 1B, and 1C of the embodiment according to the present invention, multiple algebraic helical, or spiral, notches 2 are formed around the central part 4A at equal angular intervals, extending outward from the vicinity of the central part 4A so as not to contact the outer peripheral edge of the flat plates 3A, 3B, and 3C made of an elastically deformable material. As a result, multiple spiral blade portions 7A, 7B, and 7C formed by the notches 2 are arranged at predetermined angular intervals in the circumferential direction around the central part 4A. Note that the flat plates 3B and 3C of the stirring bodies 1B and 1C shown in Figures 2 and 3 represent two different deformed forms having a multi-helic structure formed by elastically deforming the flat plate 3A of the stirring body 1A shown in Figure 1. With respect to the stirring body 1A of this embodiment shown in Figure 1, the stirring bodies 1B and 1C of this embodiment shown in Figures 2 and 3 are the same in all respects except for the flat plates 3A, 3B, and 3C which form different deformed forms by elastic deformation.

[0019] As shown in Figure 1(A), in the stirring body 1A, the four notches 2 are each located inside the outer peripheral edge of the circular flat plate 3A and are provided at 90-degree intervals around the central part 4A. They extend in a spiral shape around the central part 4A by approximately 540 degrees from the outer peripheral end 5, which is located inside the outer peripheral edge of the circular flat plate 3A and is provided at 90-degree intervals around the central part 4A, toward the inner peripheral end 6A, which is located near the central part 4A and is provided at 90-degree intervals around the central part 4A. That is, the four blade sections 7A are each positioned rotated 90 degrees circumferentially around the central part 4A relative to the adjacent blade section 7A, and are each formed to extend in a spiral shape around the central part 4A by approximately 540 degrees. Preferably, the outer peripheral end 5 of the notches 2 is formed at a distance of 5 to 10% of the diameter of the flat plate 3A from the outer peripheral edge toward the central part 4A, and preferably, the inner peripheral end 6A of the notches 2 is formed at a distance of 5 to 10% of the diameter of the flat plate 3A from the center of the flat plate 3A toward the outer peripheral edge.

[0020] Furthermore, as shown in Figures 1(B) and 1(C), the stirring body 1A has a tubular movable member 8 with a convex spherical shape at its tip, which rotatably supports the central part 4A of the flat plate 3A through a circular through-hole in the central part 4A of the flat plate 3A. A branching section on the support member 9, which is reciprocally movable inside the tube of the movable member 8, branches into two perpendicular to the movable member 8, curves along the spherical shape on the movable member 8, terminates near the outer edge of the flat plate 3A, and joins with the outer edge on the bottom side of the flat plate 3A. This allows the movable member 8 to reciprocate relative to the support member 9 in a direction that brings the outer edge and central part 4A of the flat plate 3A closer to and further away from each other. As a result, by moving the movable member 8 below the flat plate 3A in the direction normal to the flat plate 3A, i.e., pulling it down, the blade section 7A formed by the four notches 2 closes, and a two-dimensional flat plate 3A is formed.

[0021] As shown in Figures 2(A) and 2(B), in the stirring body 1B, the movable member 8 shown in Figure 1(B) is moved in the direction of arrow 10 to the extended position 11 shown in Figure 2(A), i.e., pulled up. At the same time, the central part 4A of the flat plate 3A shown in Figures 1(B) and 1(C) moves, i.e., is pulled up. As a result, the blade portion 7A extends and moves and undergoes elastic deformation, forming a three-dimensional flat plate 3B with a frustoconical blade portion 7B, as shown in Figures 2(A) and 2(B).

[0022] Furthermore, as shown in Figure 2(C), in the stirring body 1B, the movable member 8 shown in Figure 1(B) is moved in the direction of arrow 10 to the extended position 11 shown in Figure 2(A), i.e., pulled up. Simultaneously, the blade portion 7A shown in Figure 1(A) twists and extends while rotating in the direction of the notch 2 toward the center 4A, i.e., in a right-handed direction, and undergoes elastic deformation. As a result, the inner circumference end portion 6A shown in Figure 1(A) rotates approximately 20 degrees in a right-handed direction around the center 4A as the axis, and rotates to the position of the inner circumference end portion 6B shown in Figure 2(C). This forms a three-dimensional flat plate 3B having a frustoconical blade portion 7B, as shown in Figures 2(A) and 2(B).

[0023] As shown in Figures 3(A) and 3(B), in the stirring body 1C, the movable member 8 shown in Figure 2(A) is further pulled up from the extended position 11 to the extended position 12 shown in Figure 3(A), and the central part 4A of the flat plate 3B shown in Figure 2(A) is further pulled up, causing the blade portion 7B to twist and extend, and undergo elastic deformation accompanied by outward diffusion (hereinafter referred to as "diffusion movement") and convergence toward the center of the flat plate 3B (hereinafter referred to as "convergence movement"). This forms a constricted portion 13A having a neck shape as shown in Figures 3(A) and 3(B), and also forms a three-dimensional flat plate 3C having blade portions 7C that create a singularity 14 where multiple blade portions 7C converge in accordance with the strength of the pressure.

[0024] Furthermore, as shown in Figure 3(C), in the stirring body 1C, the movable member 8 shown in Figure 2(A) is further pulled up from the extended position 11 to the extended position 12 shown in Figure 3(A), and the blade portion 7B shown in Figure 2(C) twists to rotate further in the clockwise direction, undergoing elastic deformation accompanied by extension, diffusion, and convergence. As a result, the inner circumference end portion 6A shown in Figure 1(A) rotates approximately 45 degrees clockwise around the central portion 4A as the axis, and rotates to the position of the inner circumference end portion 6C shown in Figure 3(C). This forms a three-dimensional flat plate 3C having a blade portion 7C that forms a constricted portion 13A, as shown in Figures 3(A) and 3(B).

[0025] According to the aforementioned stirring bodies 1A, 1B, and 1C, the moving member 8 is capable of reciprocating relative to the support member 9 in a direction that brings the outer periphery and central part 4A of the flat plate 3A closer to and further apart from each other. When the moving member 8 is moved by predetermined physical means in the direction of the arrow 10 shown in Figure 1(B), i.e., in the direction normal to the flat plate 3A, the flat plates 3A, 3B, and 3C, which are made of an elastically deformable material having four blade portions 7A, 7B, and 7C formed by the four notches 2, elastically deform with multiple movements including twisting and stretching, thereby changing the four spiral-shaped notches. The flat plate 3A, which has a two-dimensional shape with a closed wing portion 7A, can reversibly deform into a three-dimensional shape with a frustoconical wing portion 7B, and exhibit dynamic behavior. Furthermore, from the state of the flat plate 3B, the flat plate 3B can reversibly deform into a three-dimensional shape with a wing portion 7C that forms a constricted portion 13A and generates a singularity 14 depending on the strength of the pressure, as the flat plate 3B elastically deforms while the wing portion 7B twists and extends, diffuses, and converges towards the center. Furthermore, because spiral-shaped notches 2 are formed in the flat plates 3A, 3B, and 3C, when the central part 4A of flat plate 3A is pulled up, the wing portion 7A rotates around the central part 4A as an axis in the direction of the notches 2 toward the central part 4A, i.e., in a right-handed direction, and undergoes multiple movements including extension and twisting, causing the inner circumference end portion 6A of flat plate 3A to rotate in a right-handed direction around the central part 4A as an axis and undergo elastic deformation, thereby reversibly forming a deformed form from the two-dimensional flat plate 3A to the three-dimensional flat plates 3B and 3C, enabling dynamic behavior. As a result, the notch 2 functions as a diffusion-converging structure for the blade sections 7A, 7B, and 7C, which involves expansion and contraction and rotational movement of the blade sections 7A, 7B, and 7C, as well as diffusion and convergence movement. It also functions as a displacement adjustment structure that adjusts the expansion and contraction movement range, rotational movement range, and diffusion-converging movement range of the blade sections 7A, 7B, and 7C by adjusting the length of the notch 2 that extends around the central part 4A, i.e., the angle that extends around the central part 4A (hereinafter referred to as the "circumference angle").Furthermore, the movable member 8 functions as a shape deformation adjustment for the flat plates 3A, 3B, and 3C that form the deformed shape, and also functions as a container damage protection structure that prevents damage to the inside of a container such as a stirring tank for stirring the stirred material, as the outer shape of the flat plates 3A, 3B, and 3C is circular without tip blades. Therefore, for example, if the material of the flat plates 3A, 3B, and 3C of the stirring bodies 1A, 1B, and 1C of the above-described embodiment is an elastically deformable material, and the movable member 8 is appropriately reciprocated relative to the support member 9 in a direction that brings the outer periphery and the center 4A of the flat plate 3A closer to and further away from each other by predetermined physical means, the blades 7A, 7B, and 7C will elastically deform with twisting, expanding and contracting in the vertical direction, rotational movement in the forward and reverse rotational directions, and further diffusion and diffusion convergence movements, so that the flat plates 3A, 3B, and 3C can be reversibly deformed. By dynamically behaving in a way that repeatedly forms different deformation modes, it is possible to provide a stirring blade that can stir a fluid medium in an extremely complex and unsteady manner with low shear, accompanied by multiple flow patterns such as vortices, separation flows, suction flows, push flows, swirling flows, vertical convection, circulating flows, and turbulent flows in a liquid, and by controlling the reciprocating movement distance of the moving member, the flow of the stirring flow can be adjusted by reversibly and appropriately forming deformation modes with different displacements due to elastic deformation of the flat plate, thereby preventing damage to the stirring tank and being easy to manufacture.

[0026] Furthermore, the position of the movable member 8 of the aforementioned stirring bodies 1A, 1B, and 1C is not limited to the central part 4A of the flat plates 3A, 3B, and 3C, but may also be rotatably positioned between the flat plates 3A, 3B, and 3C and the movable member 8 via a movable assist member or the like, although this is not shown in the diagram.

[0027] (First embodiment of the stirring device) A first embodiment of the stirring body according to the present invention comprises a flat plate made of an elastically deformable material, having a plurality of spiral blade portions extending from the center by spiral-shaped notches that do not contact the outer circumference, a support member that supports one of the outer circumference and the center of the flat plate, and a movable member that supports the other of the outer circumference and the center, and the movable member can be used as stirring blades of a stirring device that can unsteadily stir a fluid medium by reciprocating the outer circumference and the center relative to the support member in a direction that brings them closer together and further apart from each other. A first embodiment of a stirring device equipped with the stirring body according to the present invention will be described below with reference to Figure 4. The flat plate 3D of the stirring body 19 provided in the stirring device 15 of this embodiment shown in Figure 4 is made of an elastically deformable material and is exactly the same shape as the flat plates 3A, 3B, and 3C shown in Figures 1 to 3. The configuration of the stirring body 19 shown in Figure 4 is the same as that of the stirring bodies 1A, 1B, and 1C shown in Figures 1 to 3, except that four support members 18 are provided at 90-degree intervals around the central part 4B of the flat plate 3D and are positioned on the outer periphery, joining the flat plate 3D to the top plate 20. Therefore, a detailed explanation is omitted here.

[0028] As shown in Figure 4(A), the stirring device 15 comprises a stirring tank 16 with a volume of liquid of 300 mL, a stirring body 19 having a circular flat plate 3D, a movable member 17 and a support member 18, a top plate portion 20, a rubber seal 21 having a bellows structure, and a drive device 22 that reciprocates vertically and is equipped with a brushless motor. The drive shaft of the drive device 22, which is vertically mounted in the stirring tank 16, is joined to the movable member 17. The movable member 17 is rotatably supported on the side of the center 4B of the flat plate 3D between two adjacent convex spherical shapes at the tip of the movable member 17, passing through a circular through hole in the center 4B of the flat plate 3D. The drive shaft of the drive device 22 is connected to the seal 21 through the central opening of the top plate portion 20 so as to follow the reciprocating motion, thereby providing an airtight seal inside the stirring tank 16. The wing portion 7D represents a modified form of the flat plate 3D having a constricted portion 13B at approximately the uppermost position of the range of motion in which the movable member 17 reciprocates, while the dashed wing portion 7E represents a modified form of the flat plate 3D at approximately the lowermost position of the range of motion in which the movable member 17 reciprocates.

[0029] As shown in Figure 4(B), the agitator 15 drives the drive unit 22 by predetermined physical means to reciprocate the moving member 17 in the direction of arrow 23, and the flat plate 3D elastically deforms, causing the blades 7D and 7E to twist and expand and contract vertically, rotate in forward and reverse rotation directions, and undergo multiple movements such as diffusion and convergence. As a result, the flat plate 3D reversibly forms a deformed shape and exhibits dynamic behavior, generating multiple flows such as vortices, separation flows, suction flows, push flows, swirling flows, vertical convection, circulation flows, and turbulence in the liquid within the agitator 16. This schematically illustrates the movement of the agitated flow in the agitator 16 by the agitator 15 shown in Figure 4(A).

[0030] As shown in Figure 4(C), in the stirring device 15, four support members 18 suspended from the stirring tank 16 are arranged at 90-degree intervals around the center 4B of the flat plate 3D and positioned on the outer periphery of the flat plate 3D, and are joined to the top plate portion 20 as shown in Figure 4(A), thereby fixing the outer periphery of the flat plate 3D. As a result, by driving the drive device 22 shown in Figure 4(B) by predetermined physical means and reciprocating the moving member 17 in the direction of arrow 23, the flat plate 3D exhibits dynamic behavior such as repeatedly forming different deformation forms in a reversible manner, thereby enabling transient stirring of the liquid in the stirring tank 16.

[0031] According to the stirring device 15 equipped with the aforementioned stirring element 19, when the drive device 22, which is equipped with a brushless motor, is driven by predetermined physical means, the moving member 17 reciprocates relative to the support member 18 in a direction that brings the outer periphery and the center 4B of the flat plate 3D closer to and further apart from each other, i.e., in the direction of arrow 23, and the blades 7D and 7E of the flat plate 3D, which are made of an elastically deformable material, elastically deform with vertical expansion and contraction movement, forward and reverse rotational movement, diffusion movement and convergence movement, thereby creating a two-dimensional shape The device dynamically behaves in a way that it can repeatedly form different deformation forms in a reversible manner, from a flat 3D plate to a frustoconical 3D flat plate. Furthermore, from the state of a frustoconical 3D flat plate, the wing portion 7E twists and extends, diffuses, and converges towards the center, causing the flat plate 3D to elastically deform and reversibly form different deformation forms in a way that it can repeatedly form different deformation forms, such as a 3D flat plate having a wing portion 7D that forms a constricted portion 13B. As a result, in the liquid in the stirring tank 16, the spiral-shaped blades 7D and 7E reciprocate vertically, generating multiple vortices around adjacent blades 7D and 7E and in the gaps between them. Furthermore, the central part 4B of the flat plate 3D moves up and down, generating vertical convection. Moreover, the constricted portion 13B formed as the central part 4B of the flat plate 3D moves up and down generates vortices due to separation flow. Furthermore, the blades 7D and 7E rotate in forward and reverse directions around the central part 4B of the flat plate 3D as an axis, generating swirling flow. Furthermore, the central part 4B of the flat plate 3D is lifted, and a flow is directed from the bottom of the stirring tank 16 towards the center of the flat plate 3D. The stirring device is equipped with stirring blades that generate multiple flow types in a liquid, such as vortices, separation flows, suction flows, push flows, swirling flows, vertical convection flows, circulation flows, and turbulence, thereby generating a suction flow that rises due to the suction force, and further, when this suction flow strikes the convergent blade sections 7D, 7E and the constricted section 13B, it generates vortices and vertical convections, and further, when the central part 4B of the flat plate 3D is pulled down, the blade sections 7D, 7E and the constricted section 13B diffuse toward the bottom of the stirring tank 16, it generates downward push flows and vertical convections, thereby generating multiple flow types in the liquid, such as vortices, separation flows, suction flows, push flows, swirling flows, vertical convections, circulation flows, and turbulence, and thus functions as a stirring device that can stir a fluid medium in an extremely complex and unsteady manner with low shear.Therefore, for example, by creating a physicochemical environment suitable for the proliferation, metabolism, differentiation and maturation of megakaryocytes, multinucleation of megakaryocytes, production of platelets, and maintenance of physiological activity of platelets in the aforementioned stirring device 15, and stirring the culture medium, it is possible to perform non-steady-state stirring of the culture medium with multiple flows, low shear, and in a more complex manner than the non-steady-state stirring required for conventional stirring culture of megakaryocyte cells derived from human-type iPS cells to produce large quantities of platelets. Furthermore, it is possible to provide an easily manufactured stirring blade and a stirring device equipped with it, which do not require multiple drive devices that drive in different directions of motion or a complex mechanism for having multiple directions of motion with a single drive device, as was necessary for stirring devices having multiple directions of motion such that the stirring blades reciprocate in the vertical direction and in forward and reverse rotation directions.

[0032] The material of the seal 21 of the stirring device 15 equipped with the aforementioned stirring element 19 may be other than rubber, for example, silicone, resin, metal, polytetrafluoroethylene (registered trademark name Teflon), and the material of the seal 21 of the stirring device 15 is not particularly limited.

[0033] Furthermore, the structure of the seal 21 of the stirring device 15 equipped with the aforementioned stirring element 19 may be other than a bellows structure, for example, a flexible membrane or a diagram, and the structure of the seal 21 of the stirring device 15 is not particularly limited.

[0034] (Second embodiment of the stirring device) The first embodiment of the stirring body according to the present invention comprises a flat plate made of an elastically deformable material, having a plurality of spiral-shaped blade portions extending from the center by spiral-shaped notches that do not contact the outer circumference, a support member that supports one of the outer circumference and the center of the flat plate, and a movable member that supports the other of the outer circumference and the center. The movable member reciprocates relative to the support member in a direction that brings the outer circumference and the center closer together and further apart from each other, thereby enabling unsteady stirring of the fluid medium. Furthermore, by rotating the support member, a complex vertical reflux can be generated, enabling even and uniform stirring of the fluid medium. Moreover, it can be used as a stirring blade in a stirring device that can adjust the flow of the stirred flow. Below, with reference to Figure 5, a second embodiment of a stirring device equipped with the stirring body according to the present invention is shown. Note that the flat plate 26 of the stirring body 29 provided in the stirring device 24 of this embodiment shown in Figure 5 is the same as the flat plate 3D of the stirring body 19 shown in Figure 4, so a detailed explanation is omitted here.

[0035] As shown in Figure 5, the stirring device 24 includes a stirring tank 25 with a volume of liquid of 300 mL, a stirring body 29 comprising a circular flat plate 26 made of an elastically deformable material, a moving member 27 and a support member 28, a top plate portion 30, ceramic bearings 31 and 32, gears 33 and 34, a protective portion 35, a branching portion 36, a drive device 37 equipped with a brushless motor and a control device that can adjust the distance of movement that reciprocates in the vertical direction, and a rotational drive device 38. The moving member 27 reciprocates and the support member 28 rotates due to the drive devices 37 and 38, causing the flat plate 26 to rotate with dynamic behavior so that it repeatedly forms different deformed shapes in a reversible manner through elastic deformation. The three-dimensional flat plate 26 forming the constricted wing portion 39A has the exact same shape as the flat plate 3C shown in Figure 3, and the three-dimensional flat plate 26 having the dashed truncated cone-shaped wing portion 39B has the exact same shape as the flat plate 3B shown in Figure 2. The flat plate 26 having the wing portion 39A shows the deformation form at approximately the uppermost position of the range of motion in which the moving member 27 reciprocates, and the flat plate 26 having the wing portion 39B shows the deformation form at approximately the lowermost position of the range of motion in which the moving member 27 reciprocates. However, the material of the bearings 31 and 32 may be stainless steel, resin, or other materials in addition to ceramic, and the material of the bearings 31 and 32 is not particularly limited.

[0036] As illustrated in Figures 5(A) to 5(C), in the stirring device 24, as shown in Figure 5(A), a support member 28 having a tubular structure is provided with a gear 33 at the top of the central axis and a circular protective part 35 at the bottom to prevent liquid from adhering to the bearing 31, and is connected to the bearing 31 provided on the top plate 30. Two branching parts 36 are provided around the center of the flat plate 26 at 180-degree intervals and are joined to the protective part 35 and the outer circumference of the flat plate 26, and the gear 33 and the gear 34 on the drive shaft of the drive device 38 are rotatably combined. In addition, the movable member 27, which is the drive shaft of the drive device 37, is vertically installed in the stirring tank 25 and is connected to the bearing 33 provided on the center of the flat plate 26, so that the central side of the flat plate 26 is rotatably supported with respect to the movable member 27. As a result, when the drive shaft of the drive unit 38 rotates in the direction of arrow 40, the support member 28 having a gear 33 connected to the gear 34 rotates in the direction of arrow 41 and rotates the flat plate 26. At the same time, the moving member 27, which is the drive shaft of the drive unit 37, reciprocates in the direction of arrow 42, and the central side of the flat plate 26 reciprocates vertically, causing the flat plate 26 to elastically deform into a wing portion 39A having a constricted portion and a flat plate 26 having a frustoconical wing portion 39B, as illustrated in Figure 5(A), and the flat plate 26 rotates with dynamic behavior so that it repeatedly forms different deformed shapes in a reversible manner. The drive unit 37 is equipped with a control device that adjusts the relative travel distance between the moving member 27 and the support member 28, and can reciprocate as appropriate within the distance of the travel range 43.

[0037] According to the stirring device 24 equipped with the aforementioned stirring body 29, by driving the drive devices 37 and 38 by predetermined physical means to appropriately reciprocate and rotate the moving member 27 and the support member 28, the flat plate 26 made of an elastically deformable material undergoes dynamic behavior such as elastic deformation, causing it to repeatedly form different deformation forms in a reversible manner, from a three-dimensional flat plate 26 having a frustoconical blade portion 39B to a three-dimensional flat plate 26 forming a blade portion 39A having a constricted portion, and also allowing it to rotate around its central axis. As a result, in the liquid in the stirring tank 25, the moving member 27 reciprocates vertically, generating multiple vortices around adjacent blades 39A and 39B and in the gaps between them. Furthermore, the central part of the flat plate 26 moves up and down, generating vertical convection. Moreover, the constriction formed as the central part of the flat plate 26 moves up and down generates vortices due to separation flow. In addition, the central part of the flat plate 26 is pulled up, and a suction flow rises from the bottom of the stirring tank 25 towards the central part of the flat plate 26 due to suction force. This generates a suction flow, and as the suction flow converges and strikes the blade sections 39A, 39B and the constricted section, it generates vortices and vertical convection. Furthermore, as the center of the flat plate 26 is pulled down and the blade sections 39A, 39B and the constricted section diffuse toward the bottom of the stirring tank 25, it generates a downward pushing flow and vertical convection. This generates multiple flows such as vortices, separating flows, suction flows, pushing flows, vertical convection, circulating flows, and turbulent flows, enabling extremely complex and unsteady stirring of the fluid medium with low shear. In addition, the support member 28 rotates around the center of the three-dimensional flat plate 26, which has a dashed-line frustoconical blade section 39B, and generates a suction flow due to the suction force generated from the bottom side near the outer circumference of the flat plate 26 toward the center of the flat plate 26, along with multiple flows such as swirling flows and vertical convection, thereby generating complex vertical recirculation and enabling even and efficient stirring of the fluid medium.Furthermore, the support member 28 rotates around the center of the three-dimensional flat plate 26, which forms a blade portion 39A with a constricted portion, and generates a complex vertical recirculation with multiple flows such as suction flow due to suction force generated from the bottom side near the outer circumference of the flat plate 26 toward the center of the flat plate 26, suction flow due to suction force generated from the vicinity of the constricted portion toward the center of the flat plate 26, and swirling flow and vertical convection, thereby enabling even mixing and good agitation of the fluid medium. Moreover, by adjusting the relative movement distance between the moving member 27 and the support member 28 using the control device provided in the drive device 37, the flat plate 26 can reversibly and appropriately form multiple deformation forms with different amounts of displacement through elastic deformation, functioning as a displacement adjustment, i.e., shape deformation adjustment. Furthermore, by adjusting the direction of operation by reciprocating motion, rotational motion, or a combination thereof using the drive devices 37 and 38, it can function as an adjustment of the operation of the flat plate 26.Therefore, for example, if the material of the flat plate 26 of the stirring body 29 of the above embodiment is made of an elastically deformable material, and the drive devices 37 and 38 are driven by predetermined physical means to appropriately reciprocate and rotate the moving member 27 and the support member 28, the moving member 27 will reciprocate relative to the support member 28 in a direction that brings the outer periphery and center of the flat plate 26 closer to and further away from each other, causing the blades 39A and 39B to twist and expand and contract vertically, rotate in forward and reverse rotation directions, and also undergo diffusion and diffusion convergence movements, resulting in dynamic behavior in which the flat plate 26 repeatedly forms different deformation forms in a reversible manner, thereby creating multiple flows in the liquid such as vortex flow, separation flow, suction flow, push-out flow, swirling flow, vertical convection, circulation flow, and turbulence, with low shear and extremely complex non- This stirring blade allows for steady-state stirring, and as the support member 28 rotates around the center of the flat plate 26 as its axis, the flat plate 26 undergoes elastic deformation, dynamically reversibly repeating the formation of different deformation forms, including a three-dimensional flat plate 26 having a frustoconical blade portion 39B and a three-dimensional flat plate 26 forming a blade portion 39A having a constricted portion. This generates a complex vertical recirculation accompanied by multiple flows such as suction flow, swirling flow, and vertical convection, enabling even and efficient stirring of the fluid medium. Furthermore, the control device provided in the drive unit 37 controls the reciprocating distance of the moving member 27, allowing the flat plate 26 to reversibly and appropriately form deformation forms with different displacements through elastic deformation, thereby automatically adjusting the flow of the stirring flow. This provides an easily manufactured stirring blade. However, the configuration of the stirring device 24 that drives in multiple operating directions as described above is not limited to arranging the drive units 37 and 38 on the upper side of the stirring tank 25 by combining gears 33 and 34. For example, one of the drive units 37 and 38 may be arranged on the upper side of the stirring tank 25 and the other on the bottom side of the stirring tank 25, so that the flat plate 26 can move reciprocatingly and rotatably.

[0038] (Example of the configuration of the flat plate in the first embodiment of the stirring device) As shown in Figure 4, the stirring body 19 has a configuration in which one flat plate 3D is rotatably supported with respect to the movable member 17. However, the number of flat plates in the stirring body according to the present invention is not limited to one; for example, two or more flat plates may be connected to each other at their outer peripheries or at their centers. The number and configuration of the flat plates in the stirring body according to the present invention are not particularly limited. Figures 6 and 7 illustrate embodiments of various configurations of the flat plates in the stirring body according to the present invention. Note that the circular flat plates 3E, 3F, 3G, 3H, 3I, 3J, 3K, and 3L in the stirring bodies 44, 48, 52, 55, and 59 illustrated in Figures 6 and 7 are made of an elastically deformable material and have exactly the same shape as any of the flat plates 3A, 3B, and 3C shown in Figures 1 to 3, so a detailed explanation is omitted here.

[0039] As illustrated in Figures 6(A) and 6(B), the stirring body 44 comprises four support members 45, a connecting flat plate 46 in which a flat plate 3E is superimposed on a flat plate 3F and their outer edges are joined together, and a movable member 47. The support members 45 are provided at 90-degree intervals around the center 4C of the circular connecting flat plate 46 and are joined to the outer edge of the connecting flat plate 46, so that the outer edge of the connecting flat plate 46 is fixed to the support members 45. The movable member 47 rotatably supports the center 4C and 4D sides of the flat plates 3E and 3F between two adjacent convex spherical shapes provided at the tip and middle of the movable member 47, passing through holes in the centers 4C and 4D of the flat plates 3E and 3F, respectively. As a result, the movable member 47 reciprocates in the direction of the arrows shown, and the connecting flat plate 46 having the blades 7F and 7G as shown reversibly elastically deforms. Furthermore, the flat plate 3E has the exact same shape as the flat plate 3C, which has a three-dimensional shape as shown in Figure 3(A), and the flat plate 3F has the exact same shape as the flat plate 3B, which has a three-dimensional shape as shown in Figure 2(A), but scaled down by 30% at a 1:1 ratio. The dashed line on the flat plate 3F shows the deformed state when the movable member 47 is moved to the lowest position.

[0040] As illustrated in Figures 6(C) and 6(D), the stirring body 48 comprises two support members 49, a circular flat plate 3G, a rectangular movable assist member 50 joined to the outer circumference of the flat plate 3G, and a movable member 51. The support members 49 are provided at 180-degree intervals around the center 4E of the flat plate 3G and joined to the center 4E of the flat plate 3G, so that the center 4E side of the flat plate 3G is fixed to the support members 49. The movable member 51 rotatably supports the movable assist member 50 between two adjacent convex spherical shapes provided at the tip of the movable member 51, passing through a through hole in the center 4E of the flat plate 3G and the center of the movable assist member 50. As a result, the movable member 51 reciprocates in the direction of the arrow shown, and the flat plate 3G having the blade portion 7H as shown reversibly elastically deforms. Note that the flat plate 3G has the exact same shape as the flat plate 3C, which has a three-dimensional shape as shown in Figure 3(A), and the dashed line on the flat plate 3G shows the deformed state when the movable member 51 moves to the uppermost position.

[0041] As illustrated in Figures 6(E) and 6(F), the stirring body 52 comprises four support members 53, a circular flat plate 3H, and a movable member 54. The support members 53 are arranged at 90-degree intervals around the center 4F of the flat plate 3H and joined to the outer periphery of the flat plate 3H, thereby fixing the outer periphery of the flat plate 3H to the support members 53. The movable member 54 rotatably supports the center 4F side of the flat plate 3H between two adjacent convex spherical shapes at the tip of the movable member 54, passing through a through hole in the center 4F of the flat plate 3H. As a result, the movable member 54 reciprocates in the direction of the arrow shown, and the flat plate 3H, which has the blade portion 7I as shown, undergoes reversible elastic deformation. The flat plate 3H has the exact same shape as the three-dimensional flat plate 3C shown in Figure 3(A), and the dashed line of the flat plate 3H shows the deformation form when the movable member 54 moves to the uppermost position.

[0042] As illustrated in Figures 7(A) and 7(B), the stirring body 55 comprises a support member 56 having a U-shape, a circular connecting flat plate 57 in which flat plates 3I and 3J are joined at their outer circumferences, and a movable member 58. The central part 4H of the flat plate 3J is joined to the middle part of the support member 56, so that the central part 4H side of the connecting flat plate 57 is fixed to the support member 56. The movable member 58 rotatably supports the central part 4G side of the flat plate 3I between two adjacent convex spherical shapes provided at the tip of the movable member 58, passing through a through hole in the central part 4G of the flat plate 3I. As a result, the movable member 58 reciprocates in the direction of the arrow shown, and the connecting flat plate 57 having the blade portions 7J and 7K as shown reversibly elastically deforms. Furthermore, the flat plates 3I and 3J have exactly the same shape as the flat plate 3C, which has a three-dimensional shape as shown in Figure 3(A), and the dashed connecting flat plate 57 shows the deformed state when the movable member 58 is moved to the lowest position.

[0043] As illustrated in Figures 7(C) to 7(E), the stirring body 59 comprises four support members 60, a circular connecting flat plate 61 to which flat plates 3K and 3L are joined at their respective centers, a rectangular moving assist member 62 joined to the outer periphery of the flat plate 3L, and a moving member 63. The four support members 60 are provided at 90-degree intervals around the center 4I of the flat plate 3K and joined to the outer periphery of the flat plate 3K, so that the outer periphery of the flat plate 3K is fixed to the support members 60. The moving member 63 rotatably supports the moving assist member 62 between two adjacent convex spherical shapes provided on the moving member 63, passing through holes in the center 4I of the connecting flat plate 61 and the center of the moving assist member 62. As a result, the moving member 63 reciprocates in the direction of the arrows shown, and the connecting flat plate 61 having the blade portions 7L and 7M as shown reversibly elastically deforms. Furthermore, the flat plates 3K and 3L have exactly the same shape as the flat plate 3C, which has a three-dimensional shape as shown in Figure 3(A), and the dashed connecting flat plate 61 shows the deformed state when the movable member 63 moves to the uppermost position.

[0044] Furthermore, in all of the aforementioned flat plates 3E, 3F, 3G, 3H, 3I, 3J, 3K, and 3L, the notches are formed so as not to come into contact with the outer edges of the flat plates 3E, 3F, 3G, 3H, 3I, 3J, 3K, and 3L.

[0045] According to the aforementioned stirring bodies 44, 48, 52, 55, and 59, by appropriately combining the flat plates 3E, 3F, 3G, 3H, 3I, 3J, 3K, and 3L made of elastically deformable material, and moving the moving members 47, 51, 54, 58, and 63 in the direction normal to the flat plates 3E, 3F, 3G, 3H, 3I, 3J, 3K, and 3L, the flat plates 3E, 3F, 3G, 3H, 3I, 3J, 3K, and 3L can be reversibly formed into multiple deformation modes with different amounts of displacement by elastic deformation. Therefore, for example, if the stirring elements 44, 48, 52, 55, and 59 of this embodiment are used in place of the stirring element 19 of the stirring device 15 shown in Figure 4, the blade sections 7F, 7G, 7H, 7I, 7J, 7K, 7L, and 7M will undergo vertical expansion and contraction, rotational movement in forward and reverse directions, and furthermore, diffusion and convergence movements, causing the flat plates 3G, 3H and the connecting flat plates 46, 57, and 61 to elastically deform, thereby dynamically behaving in such a way that the flat plates 3G, 3H and the connecting flat plates 46, 57, and 61 repeatedly form reversibly different deformation forms. It is possible to provide an easily manufactured stirring blade and a stirring device equipped therewith, which can stir a fluid medium in an extremely complex, non-steady state with low shear, accompanied by multiple flow patterns such as vortices, separation flows, suction flows, push flows, swirling flows, vertical convection, circulating flows, and turbulence in a liquid, and can adjust the flow of the stirred flow by adjusting the relative movement distance between the moving members 47, 51, 54, 58, 63 and the supporting members 45, 49, 53, 56, 60, thereby reversibly and appropriately forming deformation forms with different displacement amounts through elastic deformation of the flat plates 3G, 3H and the connecting flat plates 46, 57, 61.

[0046] (Example of forming a flat plate in the first embodiment of the stirring body) As shown in Figure 1, in the flat plate 3A of the stirring body 1A, four notches 2 are formed to spiral around the center 4A by approximately 540 degrees, extending from the outer peripheral end 5, which is located inside the outer peripheral edge of the circular flat plate 3A and is provided at 90-degree intervals around the center 4A of the flat plate 3A, toward the inner peripheral end 6A, which is located near the center 4A and is provided at 90-degree intervals around the center 4A. However, the method for forming the flat plate of the stirring body according to the present invention is not limited to the method shown in Figure 1, where both ends of the notches 2 terminate inside the outer peripheral edge and near the center 4A of the flat plate 3A. For example, a flat plate with notches penetrating to the outer peripheral edge and a flat plate auxiliary member may be appropriately combined to form a shape similar to or similar to the flat plates 3A, 3B, and 3C of the stirring bodies 1A, 1B, and 1C shown in Figures 1 to 3, and to obtain the same characteristics and effects as the flat plates 3A, 3B, and 3C. The method for forming the flat plate of the stirring body according to the present invention is not particularly limited. The following examples illustrate various methods for forming the flat plates of the stirring body according to the present invention, with reference to Figure 8. The three-dimensional flat plates 64, 74, and 85 shown in Figure 8 are made of an elastically deformable material.

[0047] As illustrated in Figure 8(A), in the three-dimensional flat plate 64 that forms a constricted portion, a square through-hole is placed in the center 66 of the circular flat plate 65, and four notches 67 are formed to extend in a spiral shape around the center 66 by approximately 540 degrees, from the outer peripheral ends 68, which are provided at 90-degree intervals around the center 66 of the flat plate 65, toward the inner peripheral ends 69, which are provided at the square corners of the through-hole edges in the center 66. Furthermore, the outer shape of the flat plate auxiliary member 71A has the same shape as the through-hole in the center 66 of the flat plate 65, and a circular through-hole is provided in the center 70 of the flat plate auxiliary member 71A. As a result, by appropriately stretching and elastically deforming the center 73 of the flat plate 72, which is joined to the flat plate 65 and the flat plate auxiliary member 71A at the dashed line shown, in the direction of the arrow shown, i.e., in the direction normal to the flat plate 72, a three-dimensional flat plate 64 that forms a constricted portion can be formed from a two-dimensional flat plate 72. Furthermore, the flat plate 64 has exactly the same shape as the flat plate 3C of the stirring body 1C shown in Figure 3(B), and possesses the same characteristics and effects as the flat plate 3C of the stirring body 1C.

[0048] As illustrated in Figure 8(B), in the three-dimensional flat plate 74 that forms the constricted portion, a circular through-hole is placed in the center 76 of the flat plate 75, and four notches 77 are formed to extend in a spiral shape around the center 76 by approximately 540 degrees, from the outer peripheral end 78 located on the outer edge of the flat plate 75, which is provided at 90-degree intervals around the center 76 of the flat plate 75, toward the inner peripheral end 79 located near the center 76 and also provided at 90-degree intervals around the center 76. Furthermore, the flat plate auxiliary member 80 having a ring structure has an inner shape 81 that is the same as the outer shape of the flat plate 75, and an outer shape 82 that is circular. As a result, by appropriately stretching and elastically deforming the center 84 of the flat plate 83, which is joined to the flat plate 75 and the flat plate auxiliary member 80 at the dashed line shown, in the direction of the arrow shown, i.e., the normal direction of the flat plate 83, a three-dimensional flat plate 74 that forms the constricted portion can be formed from a two-dimensional flat plate 83. Furthermore, the flat plate 74 has exactly the same shape as the flat plate 3C of the stirring body 1C shown in Figure 3(B), and possesses the same characteristics and effects as the flat plate 3C of the stirring body 1C.

[0049] As illustrated in Figure 8(C), in the three-dimensional flat plate 85 that forms a constricted portion, a square through-hole is placed in the center 87 of the flat plate 86, and four notches 88 are formed to extend in a spiral shape around the center 87 by approximately 540 degrees, from the outer peripheral end 89 located on the outer edge of the flat plate 86, which is provided at 90-degree intervals around the center 87 of the flat plate 86, toward the inner peripheral end 90 located near the center 87 and also provided at 90-degree intervals around the center 87. Furthermore, the outer shape of the flat plate auxiliary member 71B has the same outer shape as the through-hole in the center 87 of the flat plate 86, and a circular through-hole is provided in the center of the flat plate auxiliary member 71B. The flat plate auxiliary member 91, which has a ring structure, has a circular inner shape 92 and an outer shape 93. As a result, by appropriately stretching and moving the central part 95 of the flat plate 94, which is joined to the flat plate 86, the flat plate auxiliary member 71B, and the flat plate auxiliary member 91 at the dashed line shown, in the direction of the arrow shown, i.e., the normal direction of the flat plate 94, and causing elastic deformation, a three-dimensional flat plate 85 with a constricted portion can be formed from the two-dimensional flat plate 94. The flat plate auxiliary member 71B is the same as the flat plate auxiliary member 71A shown in Figure 8(A), and the flat plate 85 is exactly the same as the flat plate 3C of the stirring body 1C shown in Figure 3(B) except for the outer circumference. The flat plate 85 and the flat plate 3C have similar shapes, and the flat plate 85 has almost the same characteristics and effects as the flat plate 3C of the stirring body 1C.

[0050] With respect to the flat plates 64, 74, and 85 of the stirring body described above, by appropriately combining the flat plates 65, 75, and 86 with the flat plate auxiliary members 71A, 71B, 80, and 91, respectively, and elastically deforming them by predetermined physical means to appropriately shape the deformed form, it is possible to form a deformed form similar to or similar to the flat plates 3A, 3B, and 3C shown in Figures 1 to 3, thereby having similar or nearly the same characteristics and effects as the flat plates 3A, 3B, and 3C of the stirring bodies 1A, 1B, and 1C shown in Figures 1 to 3.

[0051] (Example of cuts in the flat plate in the first embodiment of the stirring device) In the flat plate 3A shown in Figure 1, four spiral-shaped notches 2 are formed in the flat plate 3A, but the number and shape of the notches 2 are not particularly limited. Figure 9 illustrates embodiments of the flat plate of the stirring body according to the present invention with various notches. Note that the flat plates 96, 101, 106, and 113 shown in Figure 9 are made of an elastically deformable material.

[0052] In the example of the flat plate 96 shown in Figure 9(A), the spiral-shaped cutouts are represented as two slit-shaped cutouts 97. The two cutouts 97 are located on the inside of the outer edge of the circular flat plate 96, which has a wave-like shape formed by connecting a combination of arcs and straight lines in series. They are formed to spiral around the center 98, extending approximately 360 degrees from two outer peripheral ends 99 located 180 degrees apart around the center 98 and near the center 98, which has a circular through-hole, towards two inner peripheral ends 100 located 180 degrees apart around the center 98.

[0053] In the flat plate 101 illustrated in Figure 9(B), the four notches 102, which are formed by connecting straight lines in series, are located on the inside near the corners of the outer edge of the square flat plate 101 and are provided at 90-degree intervals around the center 103. They extend in a square spiral shape around the center 103 by approximately 360 degrees, towards the four outer circumferential ends 105 located near the center 103 which has a circular through hole and is provided at 90-degree intervals around the center 103.

[0054] In the flat plate 106 illustrated in Figure 9(C), four notches 107, which are formed by connecting a combination of arcs in series, are located on the inside near the outer edge of the regular hexagonal flat plate 106 and extend from four outer peripheral ends 109, which are provided at 90-degree intervals around the center 108, to four inner peripheral ends 110, which are located near the center 108 and provided at 90-degree intervals around the center 108, in a spiral shape that rotates approximately 360 degrees around the center 108 to the intermediate part 111. Starting from the intermediate part 111, the notches extend in the opposite direction to the spiral of the notches 107 that extend from the outer peripheral ends 109 to the intermediate part 111, in a spiral shape that rotates approximately 360 degrees around the center 108 towards the inner peripheral ends 110. Furthermore, six flaps 112 are formed on the outer periphery of the flat plate 106 by bending the outer edge of the flat plate 106 toward the center 108, starting from the dashed line shown in the figure.

[0055] In the flat plate 113 illustrated in Figure 9(D), two notches 114, formed by connecting a combination of arcs in series, are located on the inside near the outer edge of the elliptical flat plate 113 and are provided at 180-degree intervals around the center 115. From these notches 114 extend in a spiral shape around the center 115 by approximately 360 degrees toward two inner circumferential ends 117 located near the center 115 and provided at 180-degree intervals around the center 115, each notch extending toward the center 115 and containing a circular through hole. Multiple circular through holes 118 are arranged in this spiral shape.

[0056] According to the aforementioned flat plates 96, 101, 106, and 113 of the agitator, if the spiral-shaped cuts formed in the flat plate 96 are two slit-shaped cutouts 97, then, depending on the shape of the cutouts 97, the blade width, expansion / contraction movement width, rotational movement width, and diffusion / convergence movement width of the blade portion due to elastic deformation can be adjusted to reversibly form multiple deformation forms with different displacement amounts, functioning as a variable adjustment structure for the flat plate. The wave-shaped flat plate 96 can generate multiple flows accompanied by multiple small vortices, and the cuts 102 formed in the square flat plate 101 are combinations of straight lines. Because they are connected in series, a spiral notch shape can be formed that follows the shape of the polygonal flat plate. Furthermore, the notch 107, which is formed by connecting the flap 112 on the flat plate 106 in series with a combination of right-handed and left-handed winding, can generate multiple flows accompanied by multiple large vortices. Moreover, the multiple through holes 118 arranged in the elliptical flat plate 113 can generate multiple flows accompanied by multiple large and small vortices, and can also generate circulating flow even in high-viscosity liquids. As a result, for example, by using the flat plates 96, 101, 106, and 113 in place of the flat plate 3D of the stirring device 15 shown in Figure 4, multiple different deformation forms can be reversibly formed by elastic deformation, enabling dynamic behavior. This allows for the generation of circulating flow even in high-viscosity and low-viscosity fluid media, and enables extremely complex, unsteady stirring of the fluid medium with low shear, accompanied by various flows such as vortex flow, separation flow, suction flow, push-out flow, swirling flow, vertical convection, circulating flow, and turbulence in the liquid. Furthermore, the amount of displacement of the flat plates 96, 101, 106, and 113 can be adjusted by elastic deformation to reversibly and appropriately form the deformation form and adjust the flow of the stirred flow. This provides an easily manufactured stirring blade and a stirring device equipped with it.

[0057] (Second embodiment of the stirring device) In the second embodiment of the stirring bodies 201A, 201B, 201C, and 201D shown in Figure 10, the moving members that support the central part and / or the outer periphery of the flat plates 203A, 203B, 203C, and 203D, which are made of an elastically deformable material, are spaced apart from each other on the guide member 209, and are located within the flat plates 203A, 203B, 203C, and 203D so as not to contact the outer edges of the flat plates 203A, 203B, 203C, and 203D. By forming multiple algebraic spiral-shaped, or spiral-shaped, notches 2 extending outward from the vicinity of the core at equal angular intervals around the center of the flat plates 203A, 203B, 203C, and 203D, the multiple spiral-shaped wing portions 206A, 206B, 206C, and 206D formed by the notches 202 are arranged at predetermined angular intervals in the circumferential direction around the center of the flat plates 203A, 203B, 203C, and 203D. Furthermore, the flat plates 203B, 203C, and 203D of the stirring bodies 201B, 201C, and 201D shown in Figures 11 to 13 represent three different deformed forms having a multi-helix structure, formed reversibly by elastically deforming the flat plate 203A of the stirring body 201A shown in Figure 10. Compared to the stirring body 201A of this embodiment shown in Figure 10, the stirring bodies 201B, 201C, and 201D of this embodiment shown in Figures 11 to 13 are identical in all respects except for the flat plates 203B, 203C, and 203D, which each form a different deformed form through elastic deformation.

[0058] As shown in Figure 10(A), in the stirring body 201A, the four notches 2 are each located inside the outer edge of the circular flat plate 203A and are provided at 90-degree intervals around the center of the flat plate 203A. They extend in a spiral shape around the center of the flat plate 203A by approximately 540 degrees, from the outer peripheral end 204 located near the center of the flat plate 203A and provided at 90-degree intervals around that center. In other words, the four blade sections 206A are each positioned rotated 90 degrees circumferentially around the center of the flat plate 203A relative to the adjacent blade section 206A, and are each formed to extend in a spiral shape around the center of the flat plate 203A by approximately 540 degrees. Furthermore, it is preferable that the outer peripheral end 204 of the notch 202 is formed at a distance of 5 to 10% of the diameter of the flat plate 203A, extending from the outer peripheral edge toward the center of the flat plate 203A, and that the inner peripheral end 5A of the notch 202 is formed at a distance of 5 to 10% of the diameter of the flat plate 203A, extending from the center of the flat plate 203A toward the outer peripheral edge.

[0059] As shown in Figures 10(B) and 10(C), in the stirring body 201A, the movable member 207A is joined to the center of the upper side of the flat plate 203A, and the movable member 208A, which has a rectangle ending near the outer peripheral edge of the bottom side of the flat plate 203A, is joined to the outer peripheral edge of the flat plate 203A. The movable members 207A and 208A are attached to a guide member 209 that passes through a through hole in the center of the flat plate 203A, spaced apart so as to be slidable and rotatable. The movable members 207A and 208A are locked to the guide member 209 by set screws 210 and 211, so as to be unable to rotate or move in the axial direction, thereby closing the blade portion 206A formed by the four notches 2, and forming the two-dimensional flat plate 203A.

[0060] As shown in Figures 11(A) and 11(B), in the stirring body 201B, the central side of the flat plate 203A shown in Figure 10(B) is moved in the direction of arrow 212, i.e., in the direction normal to the flat plate 203A, to the extended position 213 shown in Figure 11(A), i.e., pulled up. At the same time, the central part of the flat plate 203A shown in Figures 10(A) and 10(B) moves, i.e., is pulled up, causing the blade portion 206A to twist and extend, undergoing elastic deformation. The moving members 207A and 208A are locked by the guide member 209 in a manner that prevents rotation and axial movement, due to the locking mechanisms 210 and 211 provided on the moving members 207A and 208A, thereby forming a three-dimensional flat plate 203B with a frustoconical blade portion 206B, as shown in Figures 11(A) and 11(B).

[0061] Furthermore, as shown in Figure 11(C), in the stirring body 201B, the central side of the flat plate 203A shown in Figure 10(B) is pulled up in the direction of arrow 212 to the extended position 213 shown in Figure 11(A), and the blade portion 206A shown in Figure 10(A) twists and extends while rotating in the direction of the notch 202 toward the center of the flat plate 203A, i.e., in a right-handed direction, and undergoes elastic deformation. As a result, the inner circumference end portion 205A shown in Figure 10(A) rotates approximately 20 degrees in a right-handed direction around the center of the flat plate 203A as its axis, and rotates to the position of the inner circumference end portion 205B shown in Figure 11(C). This forms a three-dimensional flat plate 203B with a frustoconical blade portion 206B, as shown in Figures 11(A) and 11(B).

[0062] As shown in Figures 12(A) and 12(B), in the agitator 201C, the central side of the flat plate 203B shown in Figure 11(A) is further raised from the extended position 213 to the extended position 214 shown in Figure 12(A), and the central part of the flat plate 203B shown in Figures 11(A) and 11(B) is further raised, causing the blade portion 206B to twist and extend, and to diffuse outward (hereinafter referred to as "diffusion movement") and converge towards the center of the flat plate 203B (hereinafter referred to as "convergence movement"). The moving members 207A and 208A undergo elastic deformation accompanied by a locking mechanism 210 and 211 provided on the moving members 207A and 208A, which locks them to the guide member 209 so that they cannot rotate or move in the axial direction. This forms a constricted portion 215A with a neck shape as shown in Figures 12(A) and 12(B), and a three-dimensional flat plate 203C having a wing portion 206C that creates a singularity 216 in which multiple wing portions 206C converge and move according to the strength of the pressure.

[0063] Furthermore, as shown in Figure 12(C), in the stirring body 201C, the central side of the flat plate 203B shown in Figure 11(A) is further raised from the extended position 213 to the extended position 214 shown in Figure 12(A), and the blade portion 206B shown in Figure 11(C) twists to rotate further in the clockwise direction, undergoing elastic deformation accompanied by extension, diffusion, and convergence. As a result, the inner circumference end portion 205A shown in Figure 10(A) rotates approximately 45 degrees clockwise around the center of the flat plate 203A as its axis, and rotates to the position of the inner circumference end portion 205C shown in Figure 12(C). This forms a three-dimensional flat plate 203C having a blade portion 206C that forms a constricted portion 215A, as shown in Figures 12(A) and 12(B).

[0064] Furthermore, as shown in Figures 13(A) and 13(B), in the stirring body 201D, the central side of the flat plate 203C shown in Figure 12(A) is rotated approximately 180 degrees around the center of the flat plate 203C from the extended position 214 to the twisting direction 217 shown in Figure 13(A), and the blade portion 206C rotates while twisting, and the blade portion 206C around the constricted portion 215A undergoes elastic deformation accompanied by reversal movement. The moving members 207A and 208A are locked to the guide member 9 by the locking mechanisms 210 and 211 provided on the moving members 207A and 208A so that they cannot rotate or move in the axial direction, thereby forming a three-dimensional flat plate 203D having multiple wave-shaped blade portions 206D with both the front and back surfaces exposed when viewed from one direction, as shown in Figures 13(A) and 13(B).

[0065] As shown in Figure 13(C), in the stirring body 201D, the central side of the flat plate 203C shown in Figure 12(A) is twisted, or rotated, by approximately 180 degrees around the center of the flat plate 203C in the opposite direction to the direction of the notch 202 toward the center of the flat plate 203C, that is, in the left-handed twisting direction 217 shown in Figure 13(A). At the same time, the blade portion 206C shown in Figure 12(C) rotates and reverses while twisting in the left-handed direction, undergoing elastic deformation. As a result, the inner circumference end portion 205C shown in Figure 12(C) rotates approximately 180 degrees around the center of the flat plate 203C in the opposite direction to the direction of the notch 202 toward the center of the flat plate 203C, that is, in the left-handed direction, and rotates to the position of the inner circumference end portion 205D shown in Figure 13(C). This results in the formation of a three-dimensional flat plate 203D having multiple wave-like fin portions 206D, with both the front and back surfaces exposed when viewed from one direction, as shown in Figures 13(A) and 13(B).

[0066] According to the aforementioned stirring bodies 201A, 201B, 201C, and 201D, the movable member 207A is joined to the center of the upper side of the flat plates 203A, 203B, 203C, and 203D, and the movable member 208A, which has a rectangle ending near the outer peripheral edge of the bottom side of the flat plates 203A, 203B, 203C, and 203D, is joined to the outer peripheral of the flat plates 203A, 203B, 203C, and 203D, and the movable members 207A and 208A slide on the guide member 209 that passes through a through hole in the center of the flat plates 203A, 203B, 203C, and 203D. Mounted rotatably spaced apart, and with locking mechanisms 210 and 211 provided on the movable members 207A and 208A using grub screws, the movable members 207A and 208A are locked to the guide member 209 in a way that prevents rotation and axial movement. As a result, the flat plates 203A, 203B, 203C, and 203D, made of an elastically deformable material, can reversibly and appropriately form multiple deformation modes with different amounts of displacement through elastic deformation. Thus, the flat plates 203A, 203B, 203C, and 203D have four spiral-shaped notches 2 that are closed. From a two-dimensional flat plate 203A having a fin portion 206A, the fin portion 206A undergoes elastic deformation accompanied by multiple movements including twisting and extension, forming a deformed form into a three-dimensional flat plate 203B having a frustoconical fin portion 206B. Furthermore, from the state of the three-dimensional flat plate 203B, the fin portion 206B undergoes further elastic deformation accompanied by multiple movements including twisting, extension, diffusion, and convergence towards the center, forming a constricted portion 215A and a singularity 216 depending on the strength of the pressure. The flat plate 203C has a three-dimensional shape with wing-like portions 206C that generate a deformation, and furthermore, from the state of the three-dimensional flat plate 203C, the central side of the flat plate 203C is rotated by approximately 180 degrees in the twisting direction 217, and the wing-like portions 206C around the constricted portion 215A undergo elastic deformation accompanied by multiple movements including rotational movement and reversal movement while twisting, thereby forming a deformed form of a complex three-dimensional flat plate 203D having multiple wave-like wing-like portions 206D whose front and back surfaces are exposed when viewed from one direction.As a result, the notch 202 functions as an extension / retraction structure, rotational structure, convergence structure, and twisting / reversing structure for the blade sections 206A, 206B, 206C, and 206D, and the length of the notch 202 that extends around the center of the flat plates 203A, 203B, 203C, and 203D, i.e., the angle at which it extends around the center of the flat plates 203A, 203B, 203C, and 203D (hereinafter referred to as the "circumference angle"), determines the extension / retraction range and rotational range of the blade sections 206A, 206B, 206C, and 206D. The movable member 207A functions as a displacement adjustment structure for a flat plate that reversibly forms multiple deformation forms with different amounts of displacement by adjusting the movable member 207A, and furthermore, the movable member 207A functions as a shape deformation structure for the flat plates 203A, 203B, 203C, and 203D that form the deformation forms. Moreover, the flat plates 203A, 203B, 203C, and 203D have an outer shape that is circular without tip wings, and thus function as a container damage protection structure that prevents damage to the inside of a container such as a stirring tank for stirring a mixture of materials.Therefore, for example, if the flat plates 203A, 203B, 203C, and 203D of the stirring bodies 201A, 201B, 201C, and 201D of this embodiment are made of an elastically deformable material, and the moving members 207A and 208A that are joined to the flat plates 203A, 203B, 203C, and 203D are locked to the guide member 209 by locking mechanisms 210 and 211 provided on the moving members 207A and 208A so that they cannot rotate or move in the axial direction, the flat plates 203A, 203B, 203C, and 203D can be reversibly and appropriately formed into multiple deformation modes with different amounts of displacement by elastic deformation. As a result, if the guide member 9 is rotated by predetermined physical means, multiple flows such as swirling flow, vertical convection, and suction flow can be generated in the liquid, resulting in multiple This stirring blade has a simple structure that prevents damage to the stirring tank, can be easily manufactured, and is low-cost. It can generate rough vertical reflux to stir the fluid medium evenly without uneven mixing. Furthermore, by reciprocating the guide member 209 in the vertical direction by predetermined physical means, it can stir the fluid medium in an extremely complex and unsteady manner with multiple flow patterns such as vortices, separation flows, vertical convection, circulation flows, and turbulence in the liquid. Moreover, by adjusting the position of the moving members 207A and 208A relative to the guide member 209, the displacement of the flat plates 203A, 203B, 203C, and 203D can be adjusted by elastic deformation, allowing the flat plates to reversibly and appropriately form multiple deformation forms with different displacement amounts through elastic deformation, thereby adjusting the flow of the stirring flow.

[0067] The position of the guide member 209 supporting the flat plates 203A, 203B, 203C, and 203D of the aforementioned stirring bodies 201A, 201B, 201C, and 201D is not limited to the center of the flat plates 203A, 203B, 203C, and 203D, but may also be on the outer periphery or both the center and outer periphery of the flat plates 203A, 203B, 203C, and 203D, although these are not shown in the figures.

[0068] (Third embodiment of the stirring device) A second embodiment of the stirring body according to the present invention comprises a flat plate made of an elastically deformable material, having multiple spiral-shaped blade portions extending from the center by spiral-shaped notches that do not contact the outer circumference, a guide member, and a movable member connected to either the center or the outer circumference of the flat plate, wherein the movable member is rotatable and movable along the guide member, and by rotating the guide member, it can be used as a stirring blade of a stirring device that can stir a fluid medium well without uneven mixing, accompanied by complex vertical reflux. A third embodiment of a stirring device equipped with the stirring body according to the present invention will be described below with reference to Figure 14. Note that the flat plate 203E of the stirring body 221 provided in the stirring device 218 of this embodiment shown in Figure 14 is made of an elastically deformable material and has exactly the same shape as the flat plate 203C shown in Figure 12, i.e., the same type is used, and the configuration of the stirring body 221 shown in Figure 14 is the same as that of the stirring body 201C shown in Figure 12, so a detailed explanation will be omitted here.

[0069] As shown in Figure 14, the stirring device 218 includes a stirring tank 219A with a volume of liquid of 300 mL, a stirring body 221 comprising a circular flat plate 203E, a guide member 220A, and movable members 207B and 208B, a top plate 222A, a rotating drive device 223A equipped with a brushless motor, and a bearing 224A. The guide member 220A, which serves as the drive shaft of the drive device 223A that is vertically mounted in the stirring tank 219A, is rotatably connected to the bearing 224A located at the central opening of the top plate 222A, thereby ensuring an airtight seal inside the stirring tank 219A.

[0070] As shown in Figures 14(A) to 14(C), in the stirring device 218, the movable member 27B is joined to the center of the upper side of the flat plate 23E, and the rectangular movable member 28B is joined to the outer circumference of the bottom side of the flat plate 23E. As shown in Figure 14(A), the movable members 207B and 208B are attached to a guide member 220A that passes through a through hole in the center of the flat plate 203E, spaced apart so as to be slidable and rotatable. The movable members 207B and 208B are locked to the guide member 220A by set screws 225A and 226A, so as not to rotate and not to move in the axial direction, thereby forming a three-dimensional flat plate 203E having four blade portions 206F that form a constricted portion 215B.

[0071] As shown in Figure 14(D), in the stirring device 218, the drive unit 223A is driven by predetermined physical means, causing the guide member 220A to rotate in the direction of the arrow shown and the three-dimensional flat plate 203E to rotate, resulting in a complex vertical reflux with multiple flow patterns such as swirling flow, vertical convection, and suction flow in the liquid. This schematically illustrates the movement of the agitated flow in the agitated tank 219A by the stirring device 218 shown in Figure 14(A).

[0072] According to the stirring device 218 equipped with the aforementioned stirring body 221, movable members 207B and 208B, which are joined to a circular flat plate 203E made of an elastically deformable material, are attached to a guide member 220A at a distance from each other so as to be slidable and rotatable. Locking mechanisms 225A and 226A, which are set screws provided on the movable members 207B and 208B, lock the movable members 207B and 208B to the guide member 220A so as not to rotate and not to move in the axial direction. By driving a drive device 223A equipped with a brushless motor by predetermined physical means, the guide member 220A is rotated in the direction of the arrow shown in Figure 14(D), making it possible to rotate the three-dimensional flat plate 203E having a blade portion 206F that forms a constricted portion 215B by elastic deformation within the stirring tank 219A. As a result, in the liquid in the stirring tank 219A, a suction flow is generated by an attractive force from the bottom side near the outer periphery of the flat plate 203E toward the center of the flat plate 203E, an attractive flow is generated by an attractive force from the vicinity of the constricted portion 215B toward the center of the flat plate 203E, and in addition, multiple flows such as swirling flow and vertical convection are generated, thereby creating a complex vertical reflux that can stir the fluid medium well without uneven mixing.

[0073] (Fourth embodiment of the stirring device) A second embodiment of the stirring body according to the present invention comprises a flat plate made of an elastically deformable material, having multiple spiral-shaped blade portions extending from the center by spiral-shaped notches that do not contact the outer circumference, a guide member, and a movable member connected to either the center or the outer circumference of the flat plate, wherein the movable member is rotatable and movable along the guide member, and by rotating the guide member, it is possible to stir a fluid medium well without uneven mixing and with complex vertical reflux, and the flow of the stirred flow can be adjusted. A fourth embodiment of a stirring device equipped with the stirring body according to the present invention will be described below with reference to Figures 15 and 16. Furthermore, the flat plates 3F and 3G of the stirring bodies 228 and 230 in the stirring devices 227 and 229 of this embodiment shown in Figures 15 and 16 are made of an elastically deformable material, and are two different deformed forms of the flat plate 203E of the stirring body 221 in the stirring device 218 shown in Figure 14. In contrast to the stirring device 218 shown in Figure 14, the stirring devices 227 and 229 shown in Figures 15 and 16 use exactly the same components as the stirring devices 228 and 229 shown in Figures 15 and 16, except for the flat plates 203F and 203G. Furthermore, the stirring element 228 shown in Figure 15 has the exact same shape as the stirring element 201B shown in Figure 11, and the stirring element 230 shown in Figure 16 has the exact same shape as the stirring element 1D shown in Figure 13. Since the stirring elements 228 and 230 shown in Figures 15 and 16 are similar to the stirring elements 201B and 201D shown in Figures 11 and 13, a detailed explanation will be omitted here.

[0074] As shown in Figure 15, the stirring device 227 includes a stirring tank 219B with a volume of liquid of 300 mL, a stirring body 228 comprising a circular flat plate 203F, a guide member 220B, and movable members 207C and 208C, a top plate 222B, a rotating drive device 223B equipped with a brushless motor, and a bearing 224B. The guide member 220B, which is suspended in the stirring tank 219B, is rotatably connected to the bearing 224B located at the central opening of the top plate 222B, thereby ensuring an airtight seal inside the stirring tank 219B.

[0075] As shown in Figures 15(A) and 15(B), in the stirring device 227, the movable member 207C is joined to the center of the upper side of the flat plate 203F, and the rectangular movable member 208C is joined to the outer circumference of the bottom side of the flat plate 203F. As shown in Figure 15(A), the movable members 207C and 208C are attached to a guide member 220B that passes through a through hole in the center of the flat plate 203F, spaced apart so as to be slidable and rotatable. Locking mechanisms 225B and 226B, which are provided on the movable members 207C and 208C with grub screws, allow the movable members 207C and 208C to move relative to the guide member. By being locked to 220B in a way that prevents rotation and axial movement, a three-dimensional flat plate 203F having a frustoconical blade portion 206G is formed. Figure 15(A) schematically shows the movement of the agitated flow in the agitated tank 219B by the agitator 227, where the drive device 223B is driven by predetermined physical means, causing the guide member 220B to rotate in the direction of the arrow shown and the three-dimensional flat plate 203F to rotate, resulting in a complex vertical recirculation with multiple flows such as swirling flow, vertical convection, and suction flow in the liquid.

[0076] According to the stirring device 227 equipped with the aforementioned stirring body 228, movable members 207C and 208C, which are joined to a circular flat plate 203F made of an elastically deformable material, are attached to a guide member 220B spaced apart so as to be slidable and rotatable. Locking mechanisms 225B and 226B, which are set screws provided on the movable members 207C and 208C, lock the movable members 207C and 208C to the guide member 220B so as not to rotate and not to move in the axial direction. By driving a drive device 223B equipped with a brushless motor by predetermined physical means, the guide member 220B is rotated in the direction of the arrow shown in Figure 15(A), making it possible to rotate the three-dimensional flat plate 203F, which has a frustoconical blade portion 206G due to elastic deformation, in the stirring tank 219B. As a result, in the liquid in the stirring tank 219B, a complex vertical reflux is generated, accompanied by multiple flow patterns such as suction flow due to the suction force generated from the bottom side near the outer periphery of the flat plate 203F toward the center of the flat plate 203F, as well as swirling flow and vertical convection, thereby enabling even and efficient mixing of the fluid medium.

[0077] As shown in Figure 16, the stirring device 229 includes a stirring tank 219C with a volume of liquid of 300 mL, a stirring body 230 comprising a circular flat plate 203G, a guide member 220C, and movable members 207D and 208D, a top plate 222C, a rotating drive device 223C equipped with a brushless motor, and a bearing 224C. The guide member 220C, which is vertically installed in the stirring tank 219C, is rotatably connected to the bearing 224C located at the central opening of the top plate 222C, thereby ensuring an airtight seal inside the stirring tank 219C.

[0078] As shown in Figures 16(A) and 16(B), in the stirring device 229, the movable member 207D is joined to the center of the upper side of the flat plate 203G, and the rectangular movable member 208D is joined to the outer circumference of the bottom side of the flat plate 203G. As shown in Figure 16(A), the movable members 207D and 208D are attached to a guide member 220C that passes through a through hole in the center of the flat plate 203G, spaced apart so as to be slidable and rotatable. Locking mechanisms 225C and 226C, provided on the movable members 207D and 208D with grub screws, prevent the movable members 207D and 208D from rotating and are fixed to the guide member 220C. Because it is locked so as not to move in the axial direction, it forms a three-dimensional flat plate 203G having multiple wave-shaped blade portions 206H whose front and back surfaces are exposed when viewed from one direction. Figure 16(A) schematically shows the movement of the agitated flow in the agitated tank 219C by the agitator 229, where the drive device 223C is driven by predetermined physical means, causing the guide member 220C to rotate in the direction of the arrow shown and the three-dimensional flat plate 203G to rotate, resulting in a complex vertical recirculation with multiple flows such as swirling flow, vertical convection, and suction flow in the liquid.

[0079] According to the stirring device 29 equipped with the aforementioned stirring body 230, movable members 207D and 208D, which are joined to a circular flat plate 203G made of an elastically deformable material, are attached to a guide member 220C at a distance from each other so as to be slidable and rotatable. Locking mechanisms 225C and 226C, which are set screws provided on the movable members 207D and 208D, appropriately lock the movable members 720D and 208D to the guide member 220C so as to be unable to rotate or move in the axial direction. By driving a drive device 223C equipped with a brushless motor by predetermined physical means, the guide member 220C is rotated in the direction of the arrow shown in Figure 16(A), thereby enabling the rotation of the three-dimensional flat plate 203G, which has multiple wave-shaped blade portions 206H whose front and back surfaces are exposed when viewed from one direction due to elastic deformation, within the stirring tank 219C. As a result, in the liquid in the stirring tank 219C, a complex vertical reflux is generated, accompanied by multiple flows such as swirling flow and vertical convection, which combine to create a suction flow due to the suction force generated from the bottom side near the outer circumference of the flat plate 203G toward the center of the flat plate 203G, a suction flow due to the suction force generated from the area around the twisted portion where the front and back surfaces of the blade portion 206H are inverted and exposed toward the center of the flat plate 203G, and multiple other flows, thereby enabling even and efficient mixing of the fluid medium.

[0080] Therefore, according to the stirring devices 218, 227, and 229 of the embodiment equipped with stirring bodies 221, 228, and 230 shown in Figures 14 to 16, the movable members 207B, 207C, 207D, 208B, 208C, and 208D that are joined to the flat plates 203E, 203F, and 203G are attached to the guide members 220A, 220B, and 220C at spaced intervals so as to be slidable and rotatable. The locking mechanisms 225A, 225B, 225C, 226A, 226B, and 226C provided on the movable members 207B, 207C, 207D, 208B, 208C, and 208D are fixed to the guide members 220A, 220B, and 220C so as not to rotate and not to move axially. Because they are locked in an uncontrollable state, the drive units 223A, 223B, and 223C, which are equipped with brushless motors, are driven by predetermined physical means to rotate the guide members 220A, 220B, and 220C. As a result, the flat plates 203E, 203F, and 203G elastically deform, causing them to reversibly and appropriately form multiple different deformation forms, including a three-dimensional flat plate 203F having a frustoconical blade portion 206G, a three-dimensional flat plate 203E having a blade portion 206F forming a constricted portion 215B, and a three-dimensional flat plate 203G having multiple wave-like blade portions 206H whose front and back surfaces are exposed when viewed from one direction, allowing them to rotate in the stirring tanks 219A, 219B, and 219C. As a result, the stirring device functions as an stirring device equipped with stirring blades that can adjust the flow of the stirring flow by adjusting the position of the moving members 207B, 207C, 207D, 208B, 208C, 208D relative to the guide members 220A, 220B, 220C, thereby reversibly and appropriately forming multiple deformation forms with different amounts of displacement of the flat plates 203E, 203F, 203G through elastic deformation.Therefore, for example, by using stirring devices 218, 227, and 229 equipped with stirring elements 221, 228, and 230 to stir a fluid medium, it is possible to provide a stirring device with a simple configuration, that is easy to manufacture and low-cost, that has stirring blades, which can stir a fluid medium well without uneven mixing by generating complex vertical reflux with multiple flow patterns such as swirling flow, vertical convection, and suction flow in the liquid, and by adjusting the position of the moving member relative to the guide member, the flow of the stirring flow can be adjusted by reversibly and appropriately forming multiple deformation forms with different displacement amounts due to the elastic deformation of the flat plate.

[0081] (Fifth embodiment of the stirring device) A second embodiment of the stirring body according to the present invention comprises a flat plate made of an elastically deformable material, having multiple spiral-shaped blade portions extending from the center by spiral-shaped notches that do not contact the outer circumference, a guide member, and a movable member connected to either the center or the outer circumference of the flat plate, wherein the movable member is rotatable and movable along the guide member, and by reciprocating the guide member, a fluid medium can be stirred in an extremely complex, non-steady manner, and the flow of the stirred flow can be adjusted. A fifth embodiment of a stirring device equipped with the stirring body according to the present invention is illustrated below with reference to Figure 17. Note that the flat plate 233A of the stirring body 237A provided in the stirring device 231 of this embodiment shown in Figure 17 is made of an elastically deformable material.

[0082] As illustrated in Figure 17, the stirring device 231 comprises a stirring tank 232 with a volume of liquid of 300 mL, a stirring body 237A comprising a circular flat plate 233A, movable members 234A, 235A, and a guide member 236A, a top plate 238, a drive device 239 equipped with a brushless motor and a control device that can adjust the reciprocating rotation distance, a bearing 240, and an auxiliary member 241A. The guide member 236A, which is the drive shaft of the drive device 239 that is vertically mounted in the stirring tank 232, is rotatably connected to the bearing 240 located at the central opening of the top plate 238, thereby ensuring an airtight seal inside the stirring tank 232. Furthermore, the three-dimensional flat plate 233A, which has multiple wave-like blade sections with exposed front and back surfaces when viewed from one direction, has the exact same shape as the three-dimensional flat plate 203D shown in Figure 13, and the three-dimensional flat plate 233A that forms the constricted section indicated by the dashed line has the exact same shape as the three-dimensional flat plate 203C shown in Figure 12. As the drive unit 239 of the stirring device 231 of this embodiment reciprocates and rotates in the left-right direction, the flat plate 233A of the stirring body 237A provided in the stirring device 231 undergoes dynamic behavior in which it elastically deforms into the exact same shape as the flat plates 203C and 203D shown in Figures 12 and 13, and reversibly repeats to form different deformation forms.

[0083] As illustrated in Figures 17(A) and 17(B), in the stirring device 231, two movable members 234A are provided around the center of the flat plate 233A at 180-degree intervals and joined to the outer periphery of the flat plate 233A, and a movable member 235A is joined to the center of the flat plate 233A, and the top plate portion 238 and the auxiliary member 241A are joined. As illustrated in Figure 17(A), the movable members 234A and 235A are slidably and rotatably attached to the auxiliary member 241A and the guide member 236A, respectively, by locking mechanisms 242A and 243A using grub screws provided on the movable members 234A and 235A, so that the movable members 234A and 235A are locked to the auxiliary member 241A and the guide member 236A, respectively, so that they cannot rotate and cannot move in the axial direction, and the outer periphery side of the flat plate 233A is fixed, thereby the drive shaft of the drive device 239 by predetermined physical means. When the guide member 236A is rotated back and forth within a range of 180 degrees in the left-right direction, the three-dimensional flat plate 233A undergoes elastic deformation, causing the central side of the flat plate 233A to rotate approximately 180 degrees in the direction of the cut toward the center, i.e., the right-handed direction, while the blade portion twists in the right-handed direction. This deformation, accompanied by multiple movements including rotation and reversal, causes the flat plate 233A to elastically deform into a three-dimensional flat plate 233A having multiple wave-shaped blade portions with both the front and back surfaces exposed when viewed from one direction, and a three-dimensional flat plate 233A forming the constricted portion shown by the dashed line in the diagram. This dynamic behavior, which repeatedly forms different deformation forms in a reversible manner, generates multiple flows in the liquid within the stirring tank 232, including vortices, suction flows, push flows, swirling flows, vertical convection, circulating flows, and turbulent flows, schematically illustrating the movement of the agitated flow within the stirring tank 232.

[0084] According to the stirring device 231 equipped with the aforementioned stirring element 237A, by using predetermined physical means to reciprocate and rotate the guide member 236A, which is the drive shaft of the drive device 239 equipped with a brushless motor, within a 180-degree driving range in the left-right direction, the central side of the circular flat plate 233A made of an elastically deformable material reciprocates and rotates in the left-right direction, and the blade portion of the flat plate 233A twists and rotates, accompanied by multiple movements including rotational movement and reversal movement. As a result, the flat plate 233A elastically deforms into a three-dimensional shape with multiple wave-like blade portions that are exposed on both sides when viewed from one direction, and a three-dimensional shape with a constricted portion, thereby exhibiting dynamic behavior that allows it to repeatedly form different deformed shapes in a reversible manner. As a result, in the liquid in the stirring tank 232, the blades around the constricted portion of the flat plate 233A twist and rotate and reverse, forming multiple wave-like blades with their front and back surfaces exposed when viewed from one direction. This generates an outward flow and a leftward swirling flow from the center of the three-dimensional flat plate 233A toward the side of the stirring tank 32. Furthermore, the multiple wave-like blades twist and converge toward the center of the flat plate 233A, generating an outward flow, and further forming the three-dimensional flat plate 233A with a constricted portion. The stirring device functions as an stirring device equipped with stirring blades that can adjust the flow of the stirring flow by adjusting the positioning of the moving members 234A and 235A relative to the guide member 236A, thereby reversibly and appropriately forming multiple deformation forms with different amounts of displacement, such as vortex flow, suction flow, pushing flow, swirling flow, vertical convection, circulating flow, and turbulence. However, the driving range for reciprocating rotation of the guide member 236A, which is the drive shaft of the drive device 239 provided in the aforementioned stirring device 231, in the left-right direction is not limited to 180 degrees, but may also be, for example, 90 degrees, 270 degrees, 360 degrees, 450 degrees, 540 degrees, 630 degrees, 720 degrees, etc., and the driving range for reciprocating rotation of the guide member 236A, which is the drive shaft of the drive device 239 provided in the aforementioned stirring device 231, in the left-right direction is not particularly limited.

[0085] (Sixth embodiment of the stirring device) A second embodiment of the stirring body according to the present invention comprises a flat plate made of an elastically deformable material, having a plurality of spiral blade portions extending from the center by spiral-shaped notches that do not contact the outer circumference, a guide member, and a movable member connected to either the center or the outer circumference of the flat plate, wherein the movable member is rotatable and movable along the guide member, and by reciprocating the guide member, it can be used as a stirring blade in a stirring device that can unsteadily stir a fluid medium and adjust the flow of the stirred flow. A sixth embodiment of a stirring device equipped with the stirring body according to the present invention is described below with reference to Figure 18. Furthermore, the flat plates 203H, 203I, and 203J of the stirring body 247 provided in the stirring device 244 of this embodiment illustrated in Figure 18 are made of an elastically deformable material, and are exactly the same shape as the flat plates 203B, 203C, and 203D of the stirring bodies 201B, 201C, and 201D shown in Figures 11 to 13, i.e., the same type of plate is used. Compared to the stirring devices 218, 227, and 229 provided in Figures 14 to 16, which are provided with stirring bodies 221, 228, and 230, the configuration of the stirring device 244 provided in Figure 18, which is provided with a stirring body 247, is the same as the configuration of the stirring devices 218, 227, and 229 shown in Figures 14 to 16, except that it is equipped with a drive device 249A that reciprocates in the vertical direction and has a brushless motor, and a rubber seal 250A with a bellows structure, so a detailed explanation is omitted here.

[0086] As illustrated in Figure 18, the stirring device 244 includes a stirring tank 245A with a volume of liquid of 300 mL, a stirring body 247 comprising a flat plate 203H, movable members 207E, 208E, and a guide member 246, a top plate 248A, a drive device 249A that reciprocates vertically and is equipped with a brushless motor, and a rubber seal 250A having a bellows structure. As shown in Figure 18(A), in the stirring device 244, the guide member 246 that is vertically installed in the stirring tank 245A is connected to the seal 250A located at the central opening of the top plate 248A so as to be able to follow the reciprocating motion, thereby providing an airtight seal inside the stirring tank 245A.

[0087] As illustrated in Figures 18(A) and 18(B), in the stirring device 244, the movable member 27E is joined to the center of the upper side of the flat plate 203H, and the rectangular movable member 208E is joined to the outer circumference of the bottom side of the flat plate 203H. The movable members 207E and 208E are attached to a guide member 246 that passes through a through hole in the center of the flat plate 203H, spaced apart so as to be slidable and rotatable. Locking mechanisms 225D and 226D, provided on the movable members 207E and 208E with grub screws, lock the movable members 207E and 208E to the guide member 246, which serves as the drive shaft of the drive device 249A, so as to be unable to rotate or move in the axial direction, thereby forming a three-dimensional flat plate 203H having a blade portion 26I that forms a constricted portion. The dashed lines on the three-dimensional flat plates 203I and 203J are formed by elastically deforming the flat plate 203H to create two different deformed forms in a reversible manner. Flat plate 203I is a deformed form having a frustoconical blade portion 206I, while flat plate 203J is a deformed form having multiple wave-like blade portions 206I that are exposed on both sides when viewed from one direction. Flat plate 203H is the same shape as flat plate 203C of the agitator 201C shown in Figure 12, flat plate 203I is the same shape as flat plate 203B of the agitator 201B shown in Figure 11, and flat plate 203J is the same shape as flat plate 203D of the agitator 201D shown in Figure 13.

[0088] According to the stirring device 244 equipped with the aforementioned stirring body 247, movable members 207E and 208E, which are joined to circular flat plates 203H, 203I, and 203J made of an elastically deformable material, are attached to the guide member 246 at a distance from each other so as to be slidable and rotatable. The movable members 207E and 208E are locked to the guide member 246 by locking mechanisms 225D and 226D using grub screws provided on the movable members 207E and 208E so as not to rotate and not to move in the axial direction. By driving the drive device 249A, which is equipped with a brushless motor, by predetermined physical means, the guide member 246 is moved back and forth in the direction of the arrow 251 shown in Figure 18(A), i.e., in the direction normal to the flat plates 203H, 203I, and 203J, thereby causing the flat plates 203H, 203I, and 203J to reciprocate in the vertical direction.As a result, when the three-dimensional flat plate 203H, which forms the blade portion 206I with a constricted portion, is moved up and down in the liquid in the stirring tank 245A, the guide member 246 moves up and down and generates multiple vortices around adjacent blade portions 206I and in the gaps between them, the center of the flat plate 203H moves up and down and generates vertical convection, the blade portion 206I with a constricted portion moves up and down and generates vortices due to separation flow around the constricted portion, and the flat plate As the outer periphery of 203H moves up and down, it generates a large vortex. Furthermore, when the three-dimensional flat plate 203I, which has frustoconical blades 206I, is moved back and forth in the vertical direction, the guide member 246 moves back and forth in the vertical direction, generating multiple vortices around adjacent blades 206I and in the gaps between them. As the center of the flat plate 203I moves up and down, it generates vertical convection. As the outer periphery of the flat plate 203I moves up and down, it generates a large vortex. Moreover, from one direction... When a complex three-dimensional flat plate 203J, which has multiple wave-shaped fin portions 206I with exposed front and back surfaces when viewed from one direction, is moved back and forth in the vertical direction, the guide member 246 moves back and forth in the vertical direction and generates multiple vortices around adjacent fin portions 206I and in the gaps between them, causing the center of the flat plate 203J to move up and down and generating vertical convection, as the multiple wave-shaped fin portions 206I with exposed front and back surfaces when viewed from one direction move up and down and around the curved portion of the fin portions 206I The stirring device functions as an stirring device equipped with stirring blades that can adjust the flow of the agitated flow by generating large vortices at the edges, thereby creating complex circulating and turbulent flows in the liquid accompanied by multiple flows such as large and small vortices, separating flows, and vertical convection, and by adjusting the position of the moving members 207E and 208E relative to the guide member 246, the flat plates 203H, 203I, and 203J are reversibly and appropriately formed into multiple deformation forms with different amounts of displacement by elastic deformation.Therefore, for example, by creating a physicochemical environment suitable for the proliferation, metabolism, differentiation and maturation of megakaryocytes, multinucleation of megakaryocytes, production of platelets, and maintenance of physiological activity of platelets in the stirring device 44 of this embodiment described above, and stirring the culture medium, it is possible to provide a stirring culture device equipped with stirring blades that can perform non-steady stirring of the culture medium in a more complex manner than the non-steady stirring required for conventional stirring culture of human-type iPS cell-derived megakaryocytes to produce large quantities of platelets.

[0089] (Seventh embodiment of the stirring device) A second embodiment of the stirring body of the present invention comprises a flat plate made of an elastically deformable material, having a plurality of spiral blade portions extending from the center by spiral-shaped notches that do not contact the outer circumference, a guide member, and a movable member connected to either the center or the outer circumference of the flat plate, wherein the movable member is rotatable and movable along the guide member, and by reciprocating the guide member, it can be used as a stirring blade of an stirring device that can unsteadily stir a fluid medium and adjust the flow of the stirred flow. A seventh embodiment of an stirring device equipped with the stirring body according to the present invention is illustrated below with reference to Figure 19. Note that the stirring body 237B provided in the stirring device 252 of this embodiment illustrated in Figure 19 is the same as the stirring body 237A shown in Figure 17, and the configuration of the stirring device 252 illustrated in Figure 19 is the same as the configuration of the stirring device 244 shown in Figure 18, except that the stirring body 237B is provided instead of the stirring body 247, so a detailed explanation is omitted here.

[0090] As illustrated in Figure 19, the stirring device 252 comprises a stirring tank 245B with a volume of liquid of 300 mL, a stirring body 237B comprising a circular flat plate 233B made of an elastically deformable material, movable members 234B and 235B and a guide member 236B, a top plate 248B, a drive device 249B equipped with a brushless motor and a control device that can adjust the reciprocating distance in the vertical direction, a seal 250B and an auxiliary member 241B. The guide member 236B, which is the drive shaft of the drive device 249B that is vertically mounted in the stirring tank 245B, is connected to the seal 250B located at the central opening of the top plate 248B so as to be able to follow the reciprocating motion, thereby ensuring that the inside of the stirring tank 245B is airtight. Furthermore, the three-dimensional flat plate 233B that forms the blade portion 253A having a constricted portion 215C has exactly the same shape as the flat plate 203C of the stirring body 201C shown in Figure 12. The flat plate 233B with the blade portion 253A is shown as a deformed form at approximately the uppermost position of the range of motion in which the guide member 236B reciprocates, and the flat plate 233B with the blade portion 253B indicated by the dashed line is shown as a deformed form at approximately the lowermost position of the range of motion in which the guide member 236B reciprocates.

[0091] As illustrated in Figures 19(A) and 19(B), in the stirring device 252, two movable members 234B are provided around the center of the flat plate 233B at 180-degree intervals and joined to the outer periphery of the flat plate 233B, a movable member 235B is joined to the center of the flat plate 233B, and the top plate portion 248B and the auxiliary member 241B are joined, and as shown in Figure 19(A), the movable members 234B and 235B are joined to the auxiliary member 241B and the guide member 236B respectively The movable members 234B and 235B are mounted spaced apart so as to be slidable and rotatable, and the locking mechanisms 242B and 243B, provided on the movable members 234B and 235B respectively with grub screws, lock the movable members 234B and 235B to the auxiliary member 241B and the guide member 236B so as not to rotate and not to move in the axial direction, thereby fixing the outer periphery of the flat plate 233B and forming a three-dimensional flat plate 233B that forms a wing portion 253A having a constricted portion 215C. As a result, by using predetermined physical means to reciprocate the guide member 236B, which is the drive shaft of the drive device 249B, in the direction of arrow 251, the flat plate 233B elastically deforms, and the blades 253A and 253B twist and undergo multiple movements such as vertical expansion and contraction, diffusion, and convergence, causing the flat plate 233B to repeatedly form different deformed shapes in a reversible manner. This dynamic behavior generates multiple flows in the liquid in the agitated tank 245B, such as vortices, separation flows, suction flows, push flows, vertical convection, circulation flows, and turbulence. Figure 19(A) schematically shows the movement of the agitated flow in the agitated tank 245B by the agitator 252.

[0092] According to the stirring device 252 equipped with the aforementioned stirring element 237B, by reciprocating the guide member 236B, which is the drive shaft of the drive device 249B equipped with a brushless motor, by predetermined physical means, the flat plate 233B made of an elastically deformable material can be dynamically behaved in a reversible manner, repeatedly forming different deformation forms from a two-dimensional flat plate 233B to a three-dimensional flat plate 233B with a frustoconical shape, and further to a three-dimensional flat plate 233B that forms a constricted portion 215C. As a result, in the liquid in the stirring tank 245B, the guide member 236B reciprocates vertically, generating multiple flows accompanied by vortices around adjacent blades 253A, 253B and in the gaps between them. Furthermore, the center of the flat plate 233B moves up and down, generating vertical convection. Moreover, the constricted portion 215C formed as the center of the flat plate 233B moves up and down generates vortices due to separation flow. Furthermore, the center of the flat plate 233B is lifted, generating a suction flow that rises from the bottom of the stirring tank 245B towards the center of the flat plate 233B due to suction force. Furthermore, this suction flow strikes the converging blades 253A, 253B and the constricted portion 215C, creating vortices and vertical convection. The stirring device functions as an stirring device equipped with stirring blades that generate convection, and furthermore, by pulling down the center of the flat plate 233B and causing the blade sections 253A, 253B and the constricted section 215C to diffusely move toward the bottom side of the stirring tank 245B, it generates a downward pushing flow and vertical convection, thereby generating multiple flow types such as vortex flow, separation flow, suction flow, pushing flow, vertical convection, circulation flow, and turbulence, enabling extremely complex unsteady stirring of the fluid medium with low shear, and by adjusting the position of the moving members 234B and 235B relative to the guide member 236B to adjust the amount of displacement of the flat plate 233B by elastic deformation, thereby reversibly and appropriately forming multiple deformation forms with different amounts of displacement by elastic deformation, thereby adjusting the flow of the stirring flow.Therefore, for example, by creating a physicochemical environment suitable for the proliferation, metabolism, differentiation and maturation of megakaryocytes, multinucleation of megakaryocytes, production of platelets, and maintenance of physiological activity of platelets in the aforementioned stirring device 252, and stirring the culture medium, it is possible to perform non-steady-state stirring of the culture medium with multiple flows, low shear, and in a more complex manner than the non-steady-state stirring required for conventional stirring culture of megakaryocytes derived from human iPS cells to produce large quantities of platelets. Furthermore, it is possible to provide an easily manufactured stirring blade and a stirring device equipped with it, without requiring multiple drive devices with different operating directions or a complex drive mechanism for the drive device, which were necessary to reciprocate the conventional stirring blade in the vertical and forward / reverse rotation directions. The flow of the stirring flow can be adjusted by adjusting the position of the moving member relative to the guide member and adjusting the amount of displacement of the flat plate by elastic deformation to appropriately form the deformation shape.

[0093] (Eighth embodiment of the stirring device) A second embodiment of the stirring body of the present invention comprises a flat plate made of an elastically deformable material, having multiple spiral-shaped blade portions extending from the center by spiral-shaped notches that do not contact the outer circumference, a guide member, and a movable member connected to either the center or the outer circumference of the flat plate, wherein the movable member is rotatable and movable along the guide member, and by rotating the guide member, a complex vertical reflux can be generated to stir the fluid medium evenly and without uneven mixing, and the stirring flow can be adjusted. An eighth embodiment of a stirring device equipped with the stirring body according to the present invention is illustrated below with reference to Figure 20. Furthermore, the blade portion 259B of the flat plate 254B of the stirring body 266 provided in the stirring device 262 of this embodiment illustrated in Figure 20 has exactly the same shape as the blade portion 206C of the flat plate 203C shown in Figure 21. The only difference between the flat plate 254B illustrated in Figure 20 and the flat plate 203C shown in Figure 21 is that the flat plate 254B is provided with through holes 260 and notches 261 on its outer circumference.

[0094] As illustrated in Figure 20(A), in the flat plate 254A, the four notches 55 are each located inside the outer peripheral edge of the circular flat plate 254A, which is made of an elastically deformable material, and are formed to extend in a spiral shape around the center 256 by approximately 540 degrees from the outer peripheral end 257, which is provided at 90-degree intervals around the center 256 of the flat plate 254A, toward the inner peripheral end 258, which is located near the center 256 and is provided at 90-degree intervals around the center 256. In other words, the four wing portions 259A are each positioned rotated 90 degrees circumferentially around the center 256 relative to the adjacent wing portion 259A, and are each formed to extend in a spiral shape around the center 256 by approximately 540 degrees. Furthermore, the flat plate 254A has a circular through hole in its center 256, four circular through holes 260 are arranged on the outer periphery of the flat plate 254A at 90-degree intervals around the center 256, and four slit-shaped notches 261 are formed at the outer periphery end 257 of the notch 255. Preferably, the outer periphery end 257 of the notch 255 is formed at a distance of 5 to 10% of the diameter of the flat plate 254A from the outer edge toward the center 256 of the flat plate 254A, and preferably the inner periphery end 258 of the notch 255 is formed at a distance of 5 to 10% of the diameter of the flat plate 254A from the center 256 toward the outer edge of the flat plate 254A.

[0095] As illustrated in Figures 20(B) to 20(D), the stirring device 262 comprises a stirring body 266 having a flat plate 254B, movable members 263 and 264, and a guide member 265, a center cap 268 having a bearing 267, two side arm caps 269, a glass stirring tank 270 with a volume of liquid containing 500 mL and openings in three places, and a magnetic stirring drive device 272 having a motor 271 with bar magnets positioned at the ends of a drive shaft having a T-shaped branch, as illustrated in Figure 20(B), the movable member 263 is joined to the bottom side of the center 256 of the flat plate 254B, and as illustrated in Figures 20(B) to 20(D), the movable member 264 has four branch sections provided at 90-degree intervals with the guide member 265 as the base point, and two bar magnets 273 are positioned at the ends of the branch sections, and polytetrafluoroethylene (trademark) The moving member 264 is sealed with Teflon, and a locking mechanism provided on the moving member 264 by screw fastening locks the moving member 264 to the tip of the guide member 265 which has a screw groove so as to be unable to rotate and move in the axial direction. The cylindrical protrusion at the tip of the branched part of the moving member 264 is fitted into the through hole 260 of the flat plate 254B so as to fix the outer circumference side of the flat plate 254B to the moving member 264. The moving member 263 is attached to the guide member 265 so as to be slidable and rotatable, spaced apart from the moving member 264, and a locking mechanism provided on the moving member 263 by fastening two screw members locks the moving member 263 to the guide member 265 which is rotatably connected to the bearing 267 so as to be unable to rotate and move in the axial direction. Thus, a three-dimensional flat plate 254B having a wing portion 259B that forms a constricted portion as illustrated in Figure 20(B) is formed. Furthermore, the stirring tank 270 is airtightly sealed by O-rings provided on the center cap 268 and the two side arm caps 269, and is positioned on top of the magnetic stirring drive device 272 as illustrated in Figure 20(B).The three-dimensional flat plate 254B, which has wing portions 259B forming a constricted portion, shows the deformed form at the uppermost position of the axial movement range of the movable member 263 attached to the guide member 265, while the flat plate 254C, which has dashed wing portions 259C, shows the deformed form at the lowermost position of the axial movement range of the movable member 263 attached to the guide member 265.

[0096] In the stirring device 262 equipped with the aforementioned stirring body 266, a movable member 264 having a bar magnet 273 is sealed with polytetrafluoroethylene (registered trademark Teflon) and joined to a guide member 265 that is rotatably connected to a bearing 267 in a center cap 268. The cylindrical protrusion at the tip of the branched portion of the movable member 264 is housed in a through hole 260 in a circular flat plate 254B made of an elastically deformable material, fixing the outer circumference of the flat plate 254B. The locking mechanism of the movable member 263, which is slidably and rotatably attached to the guide member 265, adjusts the position of the movable member 263 relative to the guide member 265, locking the movable member 263 to the guide member 265 so that it cannot rotate or move in the axial direction. By driving the magnetic stirring drive device 272 by predetermined physical means, a motor 271 having a bar magnet on the drive shaft of the magnetic stirring drive device 272 rotates, causing the flat plates 254B and 254C to rotate in the stirring tank 270 by magnetic force. As a result, in the liquid in the stirring tank 270, the three-dimensional flat plate 254B having a constricted blade portion 259B generates a suction flow due to the suction force generated from the bottom side near the outer circumference of the flat plate 254B toward the center of the flat plate 254B, the suction flow due to the suction force generated from the vicinity of the constricted portion toward the center of the flat plate 254B, and a complex vertical recirculation accompanied by multiple flows such as swirling flow and vertical convection. Furthermore, the three-dimensional flat plate 254C having a frustoconical blade portion 259C generates a suction flow near the outer circumference of the flat plate 254C The stirring device can be provided that generates a complex vertical recirculation involving a suction flow due to an attractive force generated from the side bottom towards the center of the flat plate 254C, as well as multiple flows such as swirling flow and vertical convection, thereby enabling even and efficient mixing of the fluid medium. Furthermore, the stirring flow can be adjusted by adjusting the position of the moving members 263 and 264 relative to the guide member 265 to adjust the displacement of the flat plates 254B and 254C by elastic deformation, thereby reversibly and appropriately forming multiple deformation forms with different displacements by elastic deformation.Therefore, for example, if the flat plates 254A, 254B, movable members 263, 264, guide member 265, bearing 267, center cap 268, side arm cap 269, and O-ring are processed with polytetrafluoroethylene (registered trademark Teflon), and the motor 271 provided in the magnetic stirring drive device 272 (magnetic stirrer) is driven by predetermined physical means, the flat plate 254B connected to the movable member 264 equipped with a bar magnet 273 will rotate, causing an attractive flow to be generated in the liquid in the stirring tank 270 due to the attractive force generated from the bottom side near the outer circumference of the flat plate 254B toward the center of the flat plate 254B, and from the vicinity of the constricted part toward the center of the flat plate 254B This device generates a complex vertical reflux flow involving a suction flow due to the suction force generated, as well as multiple flow patterns such as swirling flow and vertical convection, allowing for even and efficient mixing of the fluid medium. Furthermore, by adjusting the position of the moving members 263 and 264 relative to the guide member 265, the displacement of the flat plates 254A, 254B, and 254C can be adjusted, allowing for the reversible and appropriate formation of multiple deformation forms with different displacements through elastic deformation, thereby adjusting the flow of the agitated flow. Moreover, since it does not require a seal section like a direct-drive type agitator, it is free from contamination (bacterial contamination) and easy to clean. It can be used as an agitator blade and a magnetic agitator or spinner flask equipped with it. However, the flat plate 254B, movable members 263, 264, guide member 265, bearing 267, center cap 268, side arm cap 269, and O-ring may be sealed with materials other than polytetrafluoroethylene (registered trademark Teflon), such as glass coating or polycarbonate, and the materials and processing methods for the flat plate 254B, movable members 263, 264, guide member 265, bearing 267, center cap 268, side arm cap 269, and O-ring are not particularly limited. Furthermore, the means for generating magnetization in the magnetic stirring drive device 272 provided in the stirring device 262 may be an electromagnet that generates magnetization electrically, in addition to a magnet, and the means for generating magnetization in the magnetic stirring drive device of a stirring device equipped with a stirring body according to the present invention are not particularly limited.

[0097] (9th embodiment of the stirring device) A second embodiment of the stirring body of the present invention comprises a flat plate made of an elastically deformable material, having a plurality of spiral-shaped blade portions extending from the center by spiral-shaped notches that do not contact the outer circumference, a guide member, and a movable member connected to either the center or the outer circumference of the flat plate, wherein the movable member is rotatable and movable along the guide member, and by reciprocating the guide member, the fluid medium can be stirred in an unsteady state, and by rotating the guide member, a complex vertical reflux can be generated to stir the fluid medium well without uneven mixing, and furthermore, it can be used as a stirring blade in a stirring device in which the flow of the stirred flow can be adjusted. Below, with reference to Figure 21, a ninth embodiment of a stirring device equipped with the stirring body according to the present invention will be illustrated. Note that the flat plate 276 of the stirring body 279 provided in the stirring device 274 of this embodiment illustrated in Figure 21 is the same as the flat plate 233B of the stirring body 237B shown in Figure 19, so a detailed explanation will be omitted here.

[0098] As illustrated in Figure 21, the stirring device 274 includes a stirring tank 275 with a volume of liquid of 300 mL, a stirring body 279 comprising a circular flat plate 276 made of an elastically deformable material, a moving member 277 and a guide member 278, a top plate portion 280, ceramic bearings 281 and 282, gears 283 and 284, a protective portion 285, a branching portion 286, a drive unit 287 equipped with a brushless motor and a control device that can adjust the distance of movement of the vertical reciprocating movement, and a rotational drive unit 288. The moving member 277 reciprocates and the guide member 278 rotates due to the drive units 287 and 288, causing the flat plate 276 to rotate with dynamic behavior so that it repeatedly forms different deformed shapes in a reversible manner through elastic deformation. The three-dimensional flat plate 276 that forms the constricted wing portion 289A has the exact same shape as the flat plate 203C shown in Figure 12, and the three-dimensional flat plate 276 that has the dashed truncated cone-shaped wing portion 289B has the exact same shape as the flat plate 203B shown in Figure 11. The flat plate 276 with the wing portion 289A shows the deformation form at approximately the uppermost position of the range of motion in which the moving member 277 reciprocates, and the flat plate 276 with the wing portion 289B shows the deformation form at approximately the lowermost position of the range of motion in which the moving member 277 reciprocates. However, the material of the bearings 281 and 282 may be stainless steel, resin, or other materials in addition to ceramic, and the material of the bearings 281 and 282 is not particularly limited.

[0099] As illustrated in Figures 21(A) to 21(C), in the stirring device 274, as shown in Figure 21(A), a guide member 278 having a tubular structure is provided with a gear 283 at the top of the central axis and a circular protective part 285 at the bottom to prevent liquid from adhering to the bearing 281, and is connected to a bearing 281 provided on the top plate 280. Two branching parts 286 are provided around the center of the flat plate 276 at 180-degree intervals and are joined to the protective part 285 and the outer circumference of the flat plate 276, and the gear 283 and the gear 284 on the drive shaft of the drive device 288 are rotatably combined. In addition, the moving member 277, which is the drive shaft of the drive device 287, is vertically installed in the stirring tank 275 and is connected to a bearing 282 provided in the center of the flat plate 276, thereby rotatably supporting the central side of the flat plate 226 with respect to the moving member 227. As a result, when the drive shaft of the drive unit 288 rotates in the direction of arrow 290, the guide member 278, which has a gear 283 connected to the gear 284, rotates in the direction of arrow 291 and rotates the flat plate 276. At the same time, the moving member 277, which is the drive shaft of the drive unit 287, reciprocates in the direction of arrow 292, and the central side of the flat plate 276 reciprocates vertically, causing the flat plate 276 to elastically deform into a wing portion 289A with a constricted portion and a flat plate 276 with a frustoconical wing portion 289B, as illustrated in Figure 21(A), and the flat plate 276 rotates with dynamic behavior so that it repeatedly forms different deformed shapes in a reversible manner. The drive unit 287 is equipped with a control device that adjusts the distance over which the moving member 277 moves along the guide member 278, and can reciprocate as appropriate within the distance of the movement range 293.

[0100] According to the stirring device 274 equipped with the aforementioned stirring body 279, by driving the drive devices 287 and 288 by predetermined physical means to appropriately reciprocate and rotate the moving member 277 and the guide member 278, the flat plate 276 made of an elastically deformable material undergoes dynamic behavior such as elastic deformation, causing it to repeatedly form different deformation forms in a reversible manner, from a three-dimensional flat plate 276 having a frustoconical blade portion 289B to a three-dimensional flat plate 276 forming a blade portion 289A having a constricted portion, and also allowing it to rotate around its central axis. As a result, in the liquid in the stirring tank 275, the moving member 277 reciprocates vertically, generating multiple flows accompanied by vortices around adjacent blades 289A and 289B and in the gaps between them. Furthermore, the center of the flat plate 276 moves up and down, generating vertical convection. Moreover, as the center of the flat plate 276 moves up and down, the constricted portion formed generates vortices due to separation flow. Furthermore, the center of the flat plate 276 is lifted, and an upward force due to suction rises from the bottom of the stirring tank 275 towards the center of the flat plate 276. By generating a suction flow, and further generating vortices and vertical convection as the suction flow converges and strikes the blade sections 289A, 289B and the constricted section, and further generating downward pushing flows and vertical convection as the center of the flat plate 276 is pulled down and the blade sections 289A, 289B and the constricted section diffuse toward the bottom of the stirring tank 275, multiple flow patterns such as vortices, separation flows, suction flows, pushing flows, vertical convection, circulating flows, and turbulence are generated, enabling extremely complex and unsteady stirring of the fluid medium with low shear. Furthermore, the guide member 278 rotates around the center of the three-dimensional flat plate 276, which has a dashed line frustoconical blade portion 289B. Along with the suction flow generated by the suction force that flows from the bottom surface near the outer periphery of the flat plate 276 toward the center of the flat plate 276, and multiple flows such as swirling flow and vertical convection, a complex vertical recirculation is generated, enabling the fluid medium to be mixed well without unevenness.Furthermore, the guide member 278 rotates around the center of the three-dimensional flat plate 276 that forms the blade portion 289A with a constricted portion, and generates a complex vertical recirculation with multiple flows such as suction flow due to suction force generated from the bottom side near the outer circumference of the flat plate 276 toward the center of the flat plate 76, suction flow due to suction force generated from the vicinity of the constricted portion toward the center of the flat plate 276, and swirling flow and vertical convection, thereby enabling even and efficient mixing of the fluid medium. Moreover, by adjusting the relative movement distance between the moving member 277 and the guide member 278 using the control device provided in the drive device 87, the flat plate 276 can be reversibly and appropriately formed into multiple deformation forms with different amounts of displacement by elastic deformation, functioning as a displacement adjustment, i.e., shape deformation adjustment. Furthermore, by adjusting the direction of operation by reciprocating motion, rotational motion, or a combination thereof using the drive devices 287 and 288, the operation of the flat plate 276 can be adjusted.Therefore, for example, if the material of the flat plate 276 of the stirring body 279 of the above embodiment is made of an elastically deformable material, and the drive devices 287 and 288 are driven by predetermined physical means to appropriately reciprocate and rotate the moving member 277 and the guide member 278, the moving member 277 will reciprocate relative to the guide member 278 in a direction that brings the outer periphery and center of the flat plate 276 closer to and further away from each other, causing the blades 289A and 289B to twist and expand and contract vertically, rotate in forward and reverse rotation directions, and also undergo diffusion and diffusion convergence movements, resulting in dynamic behavior in which the flat plate 276 repeatedly forms different deformation forms in a reversible manner, thereby creating multiple flows in the liquid, such as vortex flow, separation flow, suction flow, push-out flow, swirling flow, vertical convection, circulation flow, and turbulence, with low shear and extremely complex fluid media. This provides an easily manufactured stirring blade that can perform transient stirring, and in which the guide member 278 rotates around the center of the flat plate 76 as a pivot, the flat plate 276 elastically deforms and dynamically behaves to reversibly repeat different deformation forms, including a three-dimensional flat plate 276 having a frustoconical blade portion 289B and a three-dimensional flat plate 276 forming a blade portion 289A having a constricted portion. This generates a complex vertical recirculation accompanied by multiple flows such as suction flow, swirling flow, and vertical convection, allowing for even and efficient stirring of the fluid medium. Furthermore, the control device provided in the drive unit 287 controls the reciprocating distance of the moving member 277, allowing the flat plate 76 to reversibly and appropriately form deformation forms with different displacements through elastic deformation, thereby automatically adjusting the flow of the stirring flow. However, the configuration of the stirring device 274 that drives in multiple operating directions as described above is not limited to arranging the drive units 287 and 288 on the upper side of the stirring tank 275 by combining gears 283 and 284. For example, one of the drive units 287 and 288 may be arranged on the upper side of the stirring tank 275 and the other on the bottom side of the stirring tank 275, so that the flat plate 276 can move reciprocatingly and rotatably.

[0101] (Example of the configuration of the flat plate in the second embodiment of the stirring device) As shown in Figure 12, in the stirring body 201C, the movable members 207A and 208A that support one flat plate 203C are arranged spaced apart from the guide member 209. However, the number of flat plates in the stirring body according to the present invention is not limited to one; for example, two or more flat plates may be connected to each other at their outer peripheries or at their centers. The number and configuration of the flat plates in the stirring body according to the present invention are not particularly limited. Figures 22 to 24 illustrate embodiments of various configurations of the flat plates in the stirring body according to the present invention. Furthermore, the circular flat plates 303K, 303L, 303M, 303N, 303O, 303P, 303Q, 303R, 303S, 303T, 303U, 303V, 303W, and 303X on the stirring bodies 294, 296, 298, 301, 304, 307, 311, and 314 illustrated in Figures 22 to 24 are made of an elastically deformable material and are exactly the same shape as, i.e., identical to, any of the flat plates 203B, 203C, and 203D shown in Figures 11 to 13, so a detailed explanation is omitted here.

[0102] As illustrated in Figure 22(A), the stirring body 394 comprises flat plates 303K and 303L, a guide member 395, and movable members 307F, 307G, 308F, and 308G. The movable members 308F and 308G, which have rectangles terminating near the outer peripheral edges on the bottom side of the respective flat plates 303K and 303L, are joined to the respective outer peripheral edges of the flat plates 303K and 303L, and the movable members 307F and 307G, which are joined to the respective centers of the flat plates 303K and 303L, are connected to the flat plates The planar plates 303K and 303L are slidably and rotatably mounted on a guide member 395 through through holes in the center of each of the planar plates 303K and 303L. A locking mechanism using grub screws on the movable members 307F, 307G, 308F, and 308G locks them to the guide member 395 so that they cannot rotate or move in the axial direction. As shown in the figure, the planar plates 303K and 303L are arranged in a vertical line relative to the guide member 395. The planar plates 303K and 303L have exactly the same shape as the planar plate 203C, which has a three-dimensional shape as shown in Figure 12.

[0103] As illustrated in Figure 22(B), the stirring body 396 comprises flat plates 303M and 303N, a guide member 397, and movable members 307H, 307I, 308H, and 308I. The movable members 308H and 308I, which have rectangles terminating near the outer edges of the respective outer edges of the flat plates 303M and 303N, are joined to the respective outer edges of the flat plates 303M and 303N, and the movable members 307H and 307I, which are joined to the respective centers of the flat plates 303M and 303N, are connected to the flat plates 303M and 330 The planar plates 303M and 303N are mounted spaced apart on a guide member 397 through through holes in the center of each N, and are slidably and rotatably attached. A locking mechanism using grub screws on the movable members 307H, 307I, 308H, and 308I locks them to the guide member 397 so that they cannot rotate or move in the axial direction. As shown in the figure, the planar plates 303M and 303N are arranged in a vertical line with their outer peripheries adjacent to each other relative to the guide member 397. The planar plates 303M and 303N have exactly the same shape as the planar plate 203C, which has a three-dimensional shape as shown in Figure 12.

[0104] As illustrated in Figure 23(A), the stirring body 398 comprises a flat plate 399 formed by joining flat plates 303O and 303P at their respective centers, a guide member 300, and movable members 308J and 308K. The movable members 308J and 308K, each having a rectangle that terminates near the outer peripheral edges of the flat plates 303O and 303P, are joined to the outer peripheral edges of the flat plates 303O and 303P, and are slidably and rotatably mounted on the guide member 300, which passes through through holes in the centers of the flat plates 303O and 303P, with a locking mechanism provided on the movable members 308J and 308K using grub screws, so that they cannot rotate or move in the axial direction, and the flat plate 399 is supported by the guide member 300 as shown. Furthermore, the flat plates 303O and 303P have exactly the same shape as the flat plate 203C, which has a three-dimensional shape as shown in Figure 12.

[0105] As illustrated in Figure 23(B), the stirring body 301 comprises a flat plate 302 to which flat plates 303Q and 303R are joined at their outer circumferences, a guide member 33, and movable members 30, 30. The movable members 30, 30, which are joined to the centers of the respective flat plates 30, 30, are attached to the guide member 33, which passes through through holes in the centers of the respective flat plates 30, 30, at a distance from each other so as to be slidable and rotatable. A locking mechanism using grub screws on the movable members 30, 30 locks the movable members 30, 30 so as not to rotate on the guide member 303 and not to move in the axial direction, and as shown in the figure, the flat plate 32 is supported by the guide member 33. Note that the flat plate 303Q has the exact same shape as the three-dimensional flat plate 203D shown in Figure 13, and the flat plate 303R has the exact same shape as the three-dimensional flat plate 203B shown in Figure 11.

[0106] As illustrated in Figure 23(C), the stirring body 304 comprises a flat plate 305 formed by overlapping a flat plate 303S on a flat plate 303T with their outer edges joined together, a guide member 306, and movable members 307L, 307M, and 308L. A movable member 308L, which has a rectangle that terminates near the outer edge of the bottom side of the flat plate 305, is joined to the outer edge of the flat plate 305, and movable members 308L is joined to the center of the flat plates 303S and 303T, respectively. Members 07L and 307M are slidably and rotatably mounted on a guide member 306 that passes through through holes in the centers of the respective flat plates 303S and 303T, respectively. A locking mechanism using grub screws on the movable members 307L, 307M, and 308L locks them to the guide member 306 so that they cannot rotate or move in the axial direction, and the flat plate 305 is supported by the guide member 306 as shown in the figure. The flat plate 303S has the exact same shape as the three-dimensional flat plate 203C shown in Figure 12, and the flat plate 303T has the exact same shape as the three-dimensional flat plate 203B shown in Figure 11, scaled down by 30% at a 1:1 ratio.

[0107] As illustrated in Figures 24(A) and 24(B), the stirring body 307 comprises a flat plate 303U, a guide member 308, and a U-shaped movable member 309. The tip of the movable member 309 is provided at 180-degree intervals around the center of the flat plate 303U and is joined to the outer circumference of the flat plate 303U. The guide member 308 is joined to the center of the flat plate 303U through a locking mechanism 310 provided in the middle of the movable member 309. The locking mechanism 310 of the movable member 309 is slidably and rotatably attached to the guide member 308. The movable member 309 is locked to the guide member 308 by a grub screw provided in the locking mechanism 310 so as not to rotate and not to move in the axial direction, and as shown, the flat plate 303U is supported by the guide member 308. The flat plate 303U has exactly the same shape as the three-dimensional flat plate 203C shown in Figure 12.

[0108] As illustrated in Figures 24(C) and 24(D), the stirring body 311 comprises a flat plate 303V, a guide member 312 having three branching sections, and movable members 307N and 313A. The two movable members 313A are arranged around the center of the flat plate 303V at 180-degree intervals and joined to the outer periphery of the flat plate 303V, and the movable member 307N is joined to the center of the flat plate 303V. The movable members 307N and 313A are attached to the guide member 312 at a distance from each other so as to be slidable and rotatable. A locking mechanism using grub screws provided on each of the movable members 307N and 313A locks them to the guide member 312 so as not to rotate and not to move in the axial direction, and as shown, the flat plate 303V is supported by the guide member 312. The flat plate 303V has exactly the same shape as the three-dimensional flat plate 203C shown in Figure 12.

[0109] As illustrated in Figures 24(E) and 24(F), the stirring body 314 comprises flat plates 303W and 303X, a guide member 315 having a rectangular frame and four branching sections, and movable members 307O, 307P, 313B, and 313C. The movable members 313B and 313C are provided at 180-degree intervals around the respective centers of the flat plates 303W and 303X and are joined to the respective outer peripheries of the flat plates 303W and 303X, while the movable members 307O and 307P are connected to the flat plates 303W and 303X. The movable members 307O, 307P, 313B, and 313C are attached to the guide member 315 at intervals so as to be slidable and rotatable, joined to the central part. The movable members 307O, 307P, 313B, and 313C are locked to the guide member 315 by a locking mechanism using grub screws, respectively, so as to be unable to rotate or move in the axial direction, and the flat plates 303W and 303X are supported by the guide member 315 as shown in the figure. The flat plates 303W and 303X have exactly the same shape as the flat plate 203C which has a three-dimensional shape as shown in Figure 12.

[0110] Furthermore, in all of the aforementioned flat plates 303K, 303L, 303M, 303N, 303O, 303P, 303Q, 303R, 303S, 303T, 303U, 303V, 303W, and 303X, the notches are formed so as not to come into contact with the outer edges of the flat plates 303K, 303L, 303M, 303N, 303O, 303P, 303Q, 303R, 303S, 303T, 303U, 303V, 303W, and 303X.

[0111] According to the aforementioned stirring bodies 394, 396, 398, 301, 304, 307, 311, and 314, flat plates 303K, 303L, 303M, 303N, 303O, 303P, 303Q, 303R, 303S, 303T, 303U, 303V, 303W, and 303X made of an elastically deformable material are appropriately combined to form movable members 307F, 307G, 308F, 308G, 307H, 307I, 308H, 308I, 308J, 308K, 307J, 307K, and 307L. The locking mechanism provided in 307M, 308L, 309, 307N, 313A, 307O, 307P, 313B, and 313C locks the guide members 395, 397, 300, 303, 306, 308, 312, and 315 so that they cannot rotate or move in the axial direction. This allows the flat plates 303K, 303L, 303M, 303N, 399, 302, 305, 303U, 303V, 303W, and 303X to reversibly form multiple deformation modes with different amounts of displacement through elastic deformation. Therefore, for example, if the stirring bodies 394, 396, 398, 301, 304, 307, 311, and 314 of this embodiment are used in place of the stirring body 221 of the stirring device 218 shown in Figure 14, the rotational movement of the flat plates 303K, 303L, 303M, 303N, 399, 302, 305, 303U, 303V, 303W, and 303X will generate complex vertical reflux with multiple flow patterns such as swirling flow, vertical convection, and suction flow in the flow, allowing for even and efficient mixing of the fluid medium. Furthermore, the moving members 307F, 307G, and 314 will be used in relation to the guide members 395, 397, 300, 303, 306, 308, 312, and 315. By adjusting the positioning of 08F, 308G, 307H, 307I, 308H, 308I, 308J, 308K, 307J, 307K, 307L, 307M, 308L, 309, 307N, 313A, 307O, 307P, 313B, and 313C, the flat plates 303K, 303L, 303M, 303N, 303O, 303P, 303Q, 303R, 303S, 303T, 303U, 303V, 303W, and 303X can reversibly and appropriately form multiple deformation forms with different displacement amounts through elastic deformation, thereby adjusting the flow of the agitated flow. This simple configuration makes it possible to provide an agitator blade and an agitator equipped with it that can be easily manufactured.

[0112] (Example of forming a flat plate in the second embodiment of the stirring body) As shown in Figure 10, in the flat plate 203A of the stirring body 201A, four notches 202 are formed to spiral around the center of the flat plate 203A by extending approximately 540 degrees from the outer peripheral end 204, which is located inside the outer peripheral edge of the circular flat plate 203A and is provided at 90-degree intervals around the center of the flat plate 203A, toward the inner peripheral end 205A, which is located near the center of the flat plate 203A and is provided at 90-degree intervals around the center. However, the method for forming the flat plate of the stirring body according to the present invention is as shown in Figure 10. In addition to the ends of the notches 202 terminating inside the outer edge and near the center of the flat plate 203A, for example, a flat plate with notches extending to the outer edge and a flat plate auxiliary member may be appropriately combined to form a shape similar to or similar to the flat plates 203A, 203B, 203C, and 203D of the stirring bodies 201A, 201B, 201C, and 201D shown in Figures 10 to 13, thereby obtaining the same characteristics and effects as the flat plates 203A, 203B, 203C, and 203D. The method for forming the flat plates of the stirring body according to the present invention is not particularly limited. Below, with reference to Figure 25, various embodiments of the flat plates of the stirring body according to the present invention will be illustrated. Note that the flat plates 316 and 327 illustrated in Figure 25 are made of an elastically deformable material.

[0113] As illustrated in Figure 25(A), in the three-dimensional flat plate 316 that forms a constricted portion, a circular through hole is placed in the center 318 of the flat plate 317, and four notches 319 are formed to extend in a spiral shape around the center 318 by approximately 540 degrees, from the outer peripheral end 320 located on the outer edge of the flat plate 317, which is provided at 90-degree intervals around the center 318, toward the inner peripheral end 321 located near the center 318 and also provided at 90-degree intervals around the center 318. Furthermore, the flat plate auxiliary member 322 having a ring structure has an inner shape 323 that is the same as the outer shape of the flat plate 317, and an outer shape 324 that is circular. As a result, by appropriately stretching and elastically deforming the central part 326 of the flat plate 325, which is joined to the flat plate 317 and the flat plate auxiliary member 322 at the dashed line shown, in the direction of the arrow shown, i.e., the normal direction of the flat plate 325, a three-dimensional flat plate 316 forming a constricted portion can be formed from the two-dimensional flat plate 325. The flat plate 316 has exactly the same shape as the flat plate 203C of the stirring body 201C shown in Figure 12(B), and has the same characteristics and effects as the flat plate 203C of the stirring body 201C.

[0114] As illustrated in Figure 25(B), in the three-dimensional flat plate 327 that forms a constricted portion, a circular through hole is placed in the center 329 of the flat plate 328, and four notches 330 are formed to extend in a spiral shape around the center 329 by approximately 540 degrees, from the outer peripheral end 331 located on the outer edge of the flat plate 328, which is provided at 90-degree intervals around the center 329, toward the inner peripheral end 332 located near the center 329 and also provided at 90-degree intervals around the center 329. In addition, the flat plate auxiliary member 333 having a ring structure has an inner shape 334 and an outer shape 335 that are circular. As a result, by appropriately stretching and elastically deforming the central part 337 of the flat plate 336, which is joined to the flat plate 328 and the flat plate auxiliary member 333 at the dashed line shown, in the direction of the arrow shown, i.e., the normal direction of the flat plate 336, a three-dimensional flat plate 327 forming a constricted portion can be formed from the two-dimensional flat plate 336. The flat plate 327 has a shape similar to the flat plate 203C of the stirring body 201C shown in Figure 12(B), and has almost the same characteristics and effects as the flat plate 203C of the stirring body 201C.

[0115] With regard to the flat plates 316 and 327 of the stirring body described above, by appropriately combining the flat plates 317 and 328 with the flat plate auxiliary members 322 and 333 and elastically deforming them by predetermined physical means to appropriately form multiple different deformation forms, deformation forms similar to or similar to those of the flat plates 203A, 203B, 203C, and 203D shown in Figures 10 to 13 can be formed, thereby having similar or nearly the same characteristics and effects as the flat plates 203A, 203B, 203C, and 203D of the stirring bodies 201A, 201B, 201C, and 201D shown in Figures 10 to 13.

[0116] (Example of cuts in the flat plate in the second embodiment of the stirring device) In the flat plate 203A shown in Figure 10, four spiral-shaped notches 202 are formed in the flat plate 203A, but the number and shape of the notches 202 are not particularly limited. Figure 26 illustrates embodiments of the flat plate of the stirring body according to the present invention with various notches. Note that the flat plates 338, 343, 348, and 355 shown in Figure 26 are made of an elastically deformable material.

[0117] In the flat plate 338 illustrated in Figure 26(A), the spiral-shaped cutouts are represented as two slit-shaped cutouts 339. The two cutouts 339 are located on the inside of the outer edge of the circular flat plate 338, which has a wave-like shape formed by connecting a combination of arcs and straight lines in series. They are formed to spiral around the center 340, extending approximately 360 degrees from two outer peripheral ends 341 located 180 degrees apart around the center 340, toward two inner peripheral ends 342 located near the center 340 and also 180 degrees apart around the center 340.

[0118] In the planar plate 343 illustrated in Figure 26(B), four notches 344, which are formed by connecting straight lines in series, are located on the inside near the corners of the outer edge of the square planar plate 343 and are provided at 180-degree intervals around the center 345. They extend in a square spiral shape around the center 345 for approximately 360 degrees, from four outer peripheral ends 346 located near the center 345 and provided at 90-degree intervals around the center 345.

[0119] In the planar plate 348 illustrated in Figure 26(C), four notches 349, formed by connecting a combination of arcs in series, extend from four outer peripheral ends 351 located near the outer edge of the regular hexagonal planar plate 348 and spaced 180 degrees around the center 150, to four inner peripheral ends 352 located near the center 350 and spaced 90 degrees around the center 350, spiraling approximately 360 degrees around the center 350 to the intermediate portion 353. Starting from the intermediate portion 353, the notches extend in the opposite direction to the spiral of the notches 349 extending from the outer peripheral ends 351 to the intermediate portion 353, spiraling approximately 360 degrees around the center 350 towards the inner peripheral ends 352. Furthermore, six flaps 354 are formed on the outer periphery of the flat plate 348 by bending the outer edge of the flat plate 348 toward the center 350, starting from the dashed line shown in the figure.

[0120] In the flat plate 355 illustrated in Figure 26(D), two notches 356, formed by connecting a combination of arcs in series, are located on the inside near the outer edge of the elliptical flat plate 355 and are provided at 180-degree intervals around the center 357. These notches extend in a spiral shape around the center 357 by approximately 360 degrees from two outer peripheral ends 358 located near the center 357 and provided at 180-degree intervals around the center 357 to two inner peripheral ends 359 located near the center 357 and provided at 180-degree intervals around the center 357, and multiple circular through holes 360 are arranged within them.

[0121] According to the aforementioned flat plates 338, 343, 348, and 355 of the agitator, if the spiral-shaped cuts formed in the flat plate 338 are two slit-shaped cutouts 339, then, depending on the shape of the cutouts 339, the blade width, expansion / contraction movement width, and rotational movement width of the blade portion due to elastic deformation can be adjusted to reversibly form multiple deformation forms with different displacements, functioning as a variable adjustment structure for the flat plate. The wave-shaped flat plate 338 can generate multiple flows accompanied by multiple small vortices, and the cuts 344 formed in the square flat plate 343 are a combination of straight lines. Because they are connected in series, a spiral-shaped notch can be formed that follows the shape of the polygonal flat plate. Furthermore, the notch 349, which is formed by connecting the flap 354 on the flat plate 348 in series with a combination of right-handed and left-handed winding, can generate multiple flows accompanied by vertical convection. Moreover, the multiple through holes 360 arranged in the elliptical flat plate 355 can generate multiple flows accompanied by multiple large and small vortices, and can also generate circulating flow even in high-viscosity liquids. As a result, for example, by using flat plates 338, 343, 348, and 355 in place of the flat plate 203E of the stirring device 218 shown in Figure 14, multiple different deformation forms can be reversibly formed by elastic deformation. This makes it possible to generate circulating flow even in high-viscosity and low-viscosity fluid media, and to stir the fluid medium by generating complex vertical recirculation accompanied by various flows such as swirling flow, vertical convection, and suction flow in the liquid. Furthermore, the amount of displacement of the flat plates 338, 343, 348, and 355 can be adjusted by elastic deformation to reversibly and appropriately form the deformation form and adjust the flow of the stirred flow. This provides an easily manufactured stirring blade and a stirring device equipped with it.

[0122] (Third embodiment of the stirring device) Figure 27 shows a third embodiment of the stirring body of the present invention. In the stirring bodies 401A, 401B, 401C, and 401D of this embodiment, the central part 404 of the flat plates 403A, 403B, 403C, and 403D, which are made of a plastically deformable material, is supported by a shaft member 408. Multiple algebraic spiral-shaped, or vortex-shaped, notches 402 are formed around the central part 404 at equal angular intervals, extending outward from the vicinity of the central part 404 so as not to contact the outer peripheral edge of the flat plates 403A, 403B, 403C, and 403D. As a result, multiple vortex-shaped blades 407A, 407B, 407C, and 407D formed by the notches 402 are arranged at predetermined angular intervals in the circumferential direction around the central part 404. Furthermore, the stirring bodies 401B, 401C, and 401D shown in Figures 28 to 30 represent three different deformed forms having a multi-helix structure formed by plastically deforming the flat plate 403A of the stirring body 401A shown in Figure 27. The stirring bodies 401B, 401C, and 401D shown in Figures 28 to 30 are identical to the stirring body 401A of this embodiment shown in Figure 27, except that they each form different deformed forms through plastic deformation.

[0123] As shown in Figure 27(A), in the stirring body 401A, the four notches 402 are each located inside the outer edge of the circular flat plate 403A and are provided at 90-degree intervals around the center 404. They extend in a spiral shape around the center 404 by approximately 540 degrees from the outer peripheral end 405, which is located near the center 404 and is provided at 90-degree intervals around the center 404, toward the inner peripheral end 406A, which is located near the center 404. In other words, the four blade sections 407A are each positioned rotated 90 degrees circumferentially around the center 404 relative to the adjacent blade section 407A, and are each formed to extend in a spiral shape around the center 404 by approximately 540 degrees. Preferably, the outer peripheral end 405 of the notch 402 is formed at a distance of 5 to 10% of the diameter of the flat plate 403A from the outer peripheral edge toward the center 404, and preferably the inner peripheral end 406A of the notch 402 is formed at a distance of 5 to 10% of the diameter of the flat plate 403A from the center toward the outer peripheral edge.

[0124] As shown in Figures 27(B) and 27(C), the flat plate 403A of the stirring body 401A is supported by the shaft member 408, which is joined to the central part 404, and the blade portion 407A formed by the four notches 402 is closed to form a two-dimensional flat plate 403A.

[0125] As shown in Figures 28(A) and 28(B), the flat plate 403B of the stirring body 401B is moved, i.e., pulled up, to the extended position 410 shown in Figure 28(A) by moving the central part 404 side of the flat plate 403A of the stirring body 401A shown in Figure 27(B) in the direction of arrow 409, i.e., in the direction normal to the flat plate 403A, and simultaneously the central part 404 of the flat plate 403A shown in Figures 27(B) and 27(C) moves, i.e., is pulled up, causing the blade portion 407A to twist and extend, undergoing plastic deformation, thereby forming a three-dimensional flat plate 403B with a frustoconical blade portion 407B as shown in Figures 28(A) and 28(B).

[0126] Furthermore, as shown in Figure 28(C), the flat plate 403B of the stirring body 401B is pulled up towards the center 404 side of the flat plate 403A of the stirring body 401A shown in Figure 27(B) in the direction of arrow 409 to the extended position 410 shown in Figure 28(A). At the same time, the blade portion 407A shown in Figure 27(A) twists and extends, rotating in the direction of the notch 402 toward the center 404 of the flat plate 403A, i.e., in a right-handed direction, and undergoes plastic deformation. As a result, the inner circumference end portion 406A of the flat plate 403A of the stirring body 401A shown in Figure 27(A) rotates approximately 20 degrees in a right-handed direction around the center 404 as the axis, and rotates to the position of the inner circumference end portion 406B shown in Figure 28(C). This results in the formation of a three-dimensional flat plate 403B having a frustoconical wing portion 407B, as shown in Figures 2(A) and 28(B).

[0127] As shown in Figures 29(A) and 29(B), the flat plate 403C of the stirring body 401C is further raised from the extended position 410 to the extended position 411 shown in Figure 29(A), while the central part 404 of the flat plate 403B of the stirring body 401B shown in Figure 28(A) is further raised, causing the blade portion 407B to twist and extend. Through plastic deformation accompanied by outward diffusion (hereinafter referred to as "diffusion movement") and convergence toward the center of the flat plate 403B (hereinafter referred to as "convergence movement"), a three-dimensional flat plate 403C is formed, which has a constricted portion 412A having a neck shape as shown in Figures 29(A) and 29(B), and a singular point 413 is created where multiple wing portions 407C converge in accordance with the strength of the pressure.

[0128] Furthermore, as shown in Figure 29(C), the flat plate 403C of the stirring body 401C is further pulled up from the extended position 410 to the extended position 411 shown in Figure 29(A), while the blade portion 407B shown in Figure 28(C) twists to rotate further in the clockwise direction, undergoing plastic deformation accompanied by extension, diffusion, and convergence. As a result, the inner circumference end 406A of the flat plate 403A of the stirring body 401A shown in Figure 27(A) rotates approximately 45 degrees clockwise around the center 404 as the axis, and rotates to the position of the inner circumference end 406C shown in Figure 29(C). This results in the formation of a three-dimensional flat plate 403C having wing portions 407C that form a constricted portion 412A, as shown in Figures 29(A) and 29(B).

[0129] As shown in Figures 30(A) and 30(B), the flat plate 403D of the stirring body 401D is formed when the central part 404 side of the flat plate 403C of the stirring body 401C shown in Figure 29(A) is rotated approximately 180 degrees around the central part 404 of the flat plate 403C, from the extended position 411 to the twisting direction 414 shown in Figure 30(A), and the blade portion 407C rotates while twisting, and the blade portion 407C around the constricted portion 412A undergoes plastic deformation accompanied by reversal movement. This results in the formation of a complex three-dimensional flat plate 403D having multiple wave-like blade portions 407D that are exposed on both sides when viewed from one direction, as shown in Figures 30(A) and 30(B).

[0130] Furthermore, as shown in Figure 30(C), the flat plate 403D of the stirring body 401C twists, or rotates, by approximately 180 degrees in the opposite direction to the direction of the notch 402 toward the center 404 of the flat plate 403C shown in Figure 29(C), that is, in the left-handed twisting direction 414 shown in Figures 30(A) and 30(B). At the same time, the blade portion 407C shown in Figure 29(C) rotates and reverses while twisting in the left-handed direction, undergoing plastic deformation. As a result, the inner circumference end portion 406C of the flat plate 403C of the stirring body 401C shown in Figure 29(C) rotates approximately 180 degrees in the left-handed direction around the center 404 as the axis, and rotates to the position of the inner circumference end portion 406D shown in Figure 30(C). This results in the formation of a three-dimensional flat plate 403D having multiple wave-like fin portions 407D, as shown in Figures 30(A) and 30(B), where both the front and back surfaces are exposed when viewed from one direction.

[0131] According to the aforementioned stirring bodies 401A, 401B, 401C, and 401D, the shaft member 408 is joined to the central part 4 of the flat plates 403A, 403B, 403C, and 403D, thereby supporting the stirring bodies 401A, 401B, 401C, and 401D with respect to the shaft member 408. When the flat plates 403A, 403B, 403C, and 403D, which are made of a material that can be plastically deformed by predetermined physical means, are plastically deformed, the two-dimensional flat plate 403A having blades 407A with four spiral-shaped notches 402 closed will plastically deform with multiple movements including twisting and extension of the blades 407A, forming a deformed form of a three-dimensional flat plate 403B having frustoconical blades 740B. Furthermore, from the state of the three-dimensional flat plate 403B Furthermore, the wing portion 407B undergoes plastic deformation with multiple movements including twisting, extension, diffusion, and convergence toward the center, forming a constricted portion 412A and a deformed form into a three-dimensional flat plate 403C having a wing portion 407C that generates a singularity 413 depending on the strength of the pressure. Moreover, from the state of the three-dimensional flat plate 403C, the central part 404 of the flat plate 403C is rotated approximately 180 degrees in the twisting direction 414, and the wing portion 407C around the constricted portion 412A undergoes plastic deformation with multiple movements including twisting, rotation, and reversal, forming a deformed form into a complex three-dimensional flat plate 403D having multiple wave-like wing portions 407D that are exposed on both sides when viewed from one direction. As a result, the notch 402 functions as an extension / contraction structure, rotational structure, convergence structure, and torsional reversal structure for the blade sections 407A, 407B, 407C, and 407D. Furthermore, the length of the notch 402 extending around the central part 404, i.e., the angle at which it extends around the central part 404 (hereinafter referred to as the "circumference angle"), adjusts the extension / contraction range, rotational range, and diffusion / convergence range of the blade sections 407A, 407B, 407C, and 407D, thereby forming multiple deformation forms with different displacements through plastic deformation. Moreover, it functions as a shape deformation structure for the flat plates 403A, 403B, 403C, and 403D that form the deformation forms.Furthermore, the flat plates 403A, 403B, 403C, and 403D, having an outer shape that is circular without tip fins, function as a container damage protection structure that prevents damage to the inside of a container such as a stirring tank used for stirring the agitated material. Therefore, for example, by using a plastically deformable material as the material for the flat plates 403A, 403B, 403C, and 403D of the stirring bodies 401A, 401B, 401C, and 401D of the above-described embodiment, and adjusting the amount of displacement by plastic deformation to appropriately form flat plates 403A, 403B, 403C, and 403D with different deformation forms, and by reciprocating the shaft member 408 that is joined to the center 404 of the stirring bodies 401A, 401B, 401C, and 401D by predetermined physical means, it is possible to stir the fluid medium in an extremely complex and unsteady manner with multiple flows such as vortices, separation flows, vertical convection, circulation flows, and turbulence in the liquid, and also predetermined objects By rotating the shaft member 8, which is connected to the central part 404 of the stirring bodies 401A, 401B, 401C, and 401D, by rational means, a complex vertical reflux is generated in the liquid, accompanied by multiple flows such as swirling flow, vertical convection, and suction flow, allowing for even and efficient mixing of the fluid medium. Furthermore, the displacement of the flat plates 403A, 403B, 403C, and 403D of the stirring bodies 401A, 401B, 401C, and 401D can be adjusted by plastic deformation to appropriately form the deformation shape and adjust the flow of the stirring flow. This provides a stirring blade that is low shear, has a simple structure, prevents damage to the stirring tank, is easy to manufacture, and is low cost.

[0132] The position of the shaft member 408 supporting the aforementioned stirring bodies 401A, 401B, 401C, and 401D is not limited to the center 404 of the flat plates 403A, 403B, 403C, and 403D, but may also be joined to the outer periphery or both the center and outer periphery of the flat plates 403A, 403B, 403C, and 403D, although these are not shown in the figures. The position of the shaft member 408 supporting the aforementioned stirring bodies 401A, 401B, 401C, and 401D is not particularly limited as long as it can support the flat plates 403A, 403B, 403C, and 403D.

[0133] (Tenth embodiment of the stirring device) The stirring body according to this embodiment includes a flat plate with multiple spiral-shaped blades extending from the center formed by spiral-shaped notches that do not contact the outer circumference. By appropriately forming deformation forms with different amounts of displacement through plastic deformation of the flat plate made of a plastically deformable material and causing it to reciprocate, it can be used as a stirring blade in a stirring device that unsteadily stirs a fluid medium. A tenth embodiment of a stirring device equipped with the stirring body according to the present invention will be described below with reference to Figure 31. Note that the flat plate 403E of the stirring body 417 provided in the stirring device 415 of this embodiment shown in Figure 31 is made of a plastically deformable material and has exactly the same shape as the flat plate 403C shown in Figure 29, i.e., the same type is used. Since the stirring body 417 shown in Figure 31 is similar to the stirring body 401C shown in Figure 29, a detailed explanation will be omitted here.

[0134] As shown in Figure 31, the stirring device 415 comprises a stirring tank 416A with a volume of liquid of 300 mL, a circular flat plate 403E of the stirring body 417, a shaft member 419A joined at the center 418 of the flat plate 403E, a top plate 420A, a rubber seal 421A having a bellows structure, and a drive device 422A that reciprocates in the vertical direction and is equipped with a brushless motor. As shown in Figures 31(A) and 31(B), in the stirring device 415, the shaft member 419A, which serves as the drive shaft of the drive device 422A that is vertically mounted in the stirring tank 416A, is connected to the seal 421A through the central opening of the top plate 420A so as to be able to follow the reciprocating motion, thereby providing an airtight seal inside the stirring tank 416A.

[0135] As shown in Figure 31(C), in the agitator 415, the drive unit 422A is driven by predetermined physical means to reciprocate the shaft member 419A in the direction of arrow 423, and the flat plate 403E of the agitator 417, which is vertically installed in the agitator tank 416A, moves up and down, resulting in the generation of multiple flows around the constricted portion 412B accompanied by vortices due to the separation flow. This schematically illustrates the movement of the agitated flow in the agitator tank 416A by the agitator 415 shown in Figure 31(A). Note that the dashed line on the flat plate 403E shown in Figure 31(C) represents the flat plate 403E at approximately the uppermost position within the range of movement of the shaft member 419A.

[0136] According to the stirring device 415 equipped with the aforementioned stirring body 17, by driving the drive unit 422A, which is equipped with a brushless motor, by predetermined physical means, the shaft member 419A, which serves as the drive shaft of the drive unit 422A, is reciprocated in the direction of arrow 423. Because the shaft member 419A is joined to the center 418 of the circular flat plate 403E, the flat plate 403E of the stirring body 417 of this embodiment, which is made of a plastically deformable material, can be moved up and down within the stirring tank 416A. As a result, in the liquid in the stirring tank 416A, the spiral-shaped blades 407E reciprocate vertically, generating multiple flows accompanied by vortices around adjacent blades 407E and in the gaps between them. Furthermore, the central part 418 of the flat plate 403E moves vertically, generating vertical convection. Additionally, the blades 407E with the constricted portion 412B move vertically, generating vortices due to separation flow around the constricted portion 412B. Moreover, the outer periphery of the flat plate 403E moves vertically, generating large vortices around the outer edge. This generates multiple flows such as vortices, separation flow, vertical convection, circulation flow, and turbulence, thereby functioning as a stirring device equipped with stirring blades that can stir the fluid medium in an extremely complex, unsteady manner with low shear. Therefore, for example, by creating a physicochemical environment suitable for the proliferation, metabolism, differentiation and maturation of megakaryocytes, multinucleation of megakaryocytes, production of platelets, and maintenance of physiological activity of platelets in the aforementioned stirring device 415, and stirring the culture medium, it is possible to provide an easily manufactured stirring blade and a stirring culture apparatus equipped therewith that can perform non-steady stirring of the culture medium with multiple flows, low shear, and in a more complex manner than the non-steady stirring required for conventional stirring culture of human-type iPS cell-derived megakaryocytes to produce large quantities of platelets.

[0137] (11th embodiment of the stirring device) A third embodiment of the stirring body according to the present invention includes a flat plate on which a plurality of spiral-shaped blade portions extending from the center are formed by spiral-shaped notches that do not contact the outer circumference. By appropriately forming deformation forms with different amounts of displacement through plastic deformation of the flat plate made of a plastically deformable material and causing it to reciprocate, it is possible to unsteadily stir a fluid medium and it is possible to adjust the flow of the stirred flow. An eleventh embodiment of a stirring device equipped with the stirring body according to the present invention will be described below with reference to Figures 32 and 33. Furthermore, the flat plates 403F and 403G of the stirring bodies 425 and 429 in this embodiment shown in Figures 32 and 33 are made of a plastically deformable material, and two different deformation forms other than the flat plate 403E of the stirring body 417 shown in Figure 31 are used, formed by plastic deformation. The stirring bodies 425 and 429 shown in Figures 32 and 33 are exactly the same shape as the stirring bodies 401B and 401D shown in Figures 28 and 30, and the stirring devices 424 and 428 in this embodiment shown in Figures 32 and 33 are exactly the same as the stirring device 415 shown in Figure 31, except for the flat plates 403F and 403G of the stirring bodies 425 and 429 in this embodiment, so a detailed explanation is omitted here.

[0138] As shown in Figure 32, the stirring device 424 comprises a stirring tank 416B with a volume of liquid of 300 mL, a flat plate 403F of the stirring body 425, a shaft member 419B joined at the center 426 of the flat plate 403F, a top plate 420B, a rubber seal 421B having a bellows structure, and a reciprocating drive device 422B equipped with a brushless motor. Note that the flat plate 403F of the stirring body 425 is the same as the flat plate 403B of the stirring body 401B shown in Figure 28, so a detailed explanation is omitted here.

[0139] As shown in Figures 32(A) and 32(B), in the stirring device 424, the shaft member 419B, which serves as the drive shaft of the drive device 422B, is joined to the center 426 of the flat plate 403F of the stirring body 425, which has frustoconical blades 407F, and is connected to the seal 421B through the central opening of the top plate 420B so as to be able to follow the reciprocating motion. As a result, the inside of the stirring tank 416B is airtight. When the drive device 422B is driven by predetermined physical means, the shaft member 419B is moved back and forth in the direction of arrow 427, and the flat plate 403F of the stirring body 425, which is suspended in the stirring tank 416B, moves up and down, generating multiple flows accompanied by multiple vortices around adjacent blades 407F and in the gaps between them. Figure 32(A) schematically shows the movement of the stirred flow inside the stirring tank 416B by the stirring device 424. The dashed line on the flat plate 403F shown in Figure 32(A) represents the flat plate 403F at approximately the uppermost position within the range of motion during which the shaft member 419B reciprocates.

[0140] As shown in Figure 33, the stirring device 428 comprises a stirring tank 416C with a volume of liquid of 300 mL, a flat plate 403G of the stirring body 429, a shaft member 419C joined at the center 430 of the flat plate 403G, a top plate 420C, a rubber seal 421C with a bellows structure, and a reciprocating drive device 422C equipped with a brushless motor. Note that the flat plate 403G of the stirring body 429 is the same as the flat plate 403D of the stirring body 401D shown in Figure 30, so a detailed explanation is omitted here.

[0141] As shown in Figures 33(A) and 33(B), in the stirring device 428, the shaft member 419C, which serves as the drive shaft of the drive device 422C, is joined to the center 430 of the flat plate 403G of the stirring body 429, which has multiple wave-shaped blades 407G whose front and back surfaces are exposed when viewed from one direction, and is connected to the seal 421C through the central opening of the top plate 420C so as to be able to follow the reciprocating motion, thereby providing an airtight environment inside the stirring tank 416C, and the drive device 42 When 2C is driven, the shaft member 419C is moved back and forth in the direction of arrow 431, and the flat plate 403G of the stirring body 429, which is suspended in the stirring tank 416C, moves up and down. As a result, when viewed from one direction, multiple wave-shaped blade portions 407G, whose front and back surfaces are exposed, move up and down, and multiple flows accompanied by large vortices are generated around the curved portions of the blade portions 407G. Figure 33(A) schematically shows the movement of the stirred flow in the stirring tank 416C by the stirring device 428. Note that the dashed line on the flat plate 403G shown in Figure 33(A) represents the flat plate 403G at approximately the uppermost position within the range of movement of the shaft member 419C as it reciprocates.

[0142] According to the stirring devices 424 and 428 equipped with the aforementioned stirring bodies 425 and 429, by driving the drive devices 422B and 422C, which are equipped with brushless motors, by predetermined physical means, and reciprocating the shaft members 419B and 419C, which serve as the drive shafts of the drive devices 422B and 422C, in the direction of the arrows 427 and 431 shown in Figures 32(A) and 33(A), the shaft members 419B and 419C are joined to the central parts 426 and 430 of the circular flat plates 403F and 403G, respectively, so that the flat plates 403F and 403G of the stirring bodies 425 and 429 of this embodiment, which are made of a plastically deformable material, can be moved up and down within the stirring tanks 416B and 416C. As a result, in the liquid in the stirring tank 416B, the three-dimensional flat plate 403F having frustoconical blades 407F causes the spiral blades 407F to reciprocate vertically, generating multiple vortices around adjacent blades 407F and in the gaps between them, the center of the flat plate 403F moves up and down and generates vertical convection, the outer periphery of the flat plate 403F moves up and down and generates large vortices around the outer edge, and furthermore, the complex three-dimensional flat plate 403G having multiple wave-like blades 407G whose front and back surfaces are exposed when viewed from one direction generates spiral The blade portion 407G reciprocates vertically, generating multiple vortices around adjacent blade portions 407G and in the gaps between them, the central part of the flat plate 403G moves vertically, generating vertical convection, and the multiple wave-shaped blade portions 407G, whose front and back surfaces are exposed when viewed from one direction, move vertically, generating large vortices around the curved portions of the blade portions 407G. This generates multiple flow patterns such as large and small vortices, separating flows, vertical convection, circulating flows, and turbulence in the liquid, thereby functioning as an agitator equipped with agitating blades that can stir the fluid medium in an extremely complex, unsteady manner with low shear.Therefore, for example, by creating a physicochemical environment suitable for the proliferation, metabolism, differentiation and maturation of megakaryocytes, multinucleation of megakaryocytes, production of platelets, and maintenance of physiological activity of platelets in the aforementioned stirring devices 424 and 428, and stirring the culture medium, it is possible to provide easily manufactured stirring blades and a stirring device equipped therewith that can perform complex, non-steady-state stirring of the culture medium with multiple flows and low shear, compared to the non-steady-state stirring required for conventional stirring culture of human-type iPS cell-derived megakaryocytes to produce large quantities of platelets.

[0143] Furthermore, according to the stirring devices 415, 424, and 428 equipped with stirring bodies 417, 425, and 429 shown in Figures 31 to 33, the drive devices 422A, 422B, and 422C are driven by predetermined physical means to reciprocate the shaft members 419A, 419B, and 419C, which serve as drive shafts for the drive devices 422A, 422B, and 422C, in the direction of the arrows 423, 427, and 431 shown in Figures 31 to 33, and the stirring bodies 417, 425, and 429, which have blade portions 407E, 407F, and 407G The flat plates 403E, 403F, and 403G reciprocate vertically, generating multiple different flow patterns in the liquid within the stirring tanks 416A, 416B, and 416C. This allows for extremely complex, non-steady-state stirring of the fluid medium with low shear, and the flow of the stirring flow can be adjusted by plastically deforming the flat plates 403E, 403F, and 403G by predetermined physical means to appropriately form deformation patterns with different displacements. This functions as an easily manufactured stirring blade and a stirring device equipped with it. Therefore, for example, by creating a physicochemical environment suitable for the proliferation, metabolism, differentiation and maturation of megakaryocytes, multinucleation of megakaryocytes, production of platelets, and maintenance of physiological activity of platelets in the aforementioned stirring devices 415, 424, and 428, and stirring the culture medium, it is possible to provide an easily manufactured stirring blade and a stirring culture apparatus equipped therewith, which allows for more complex, low-shear, and multiple flow patterns of the culture medium compared to the non-steady-state stirring required for conventional stirring culture of human-type iPS cell-derived megakaryocytes to produce large quantities of platelets, and also allows for adjusting the flow of the stirring flow by adjusting the displacement of the flat plate through plastic deformation to appropriately form different deformation shapes.

[0144] (Twelfth embodiment of the stirring device) A third embodiment of the stirring body according to the present invention comprises a flat plate on which a plurality of spiral-shaped blades extending from the center are formed by spiral-shaped notches that do not contact the outer circumference. By appropriately forming deformation forms with different amounts of displacement through plastic deformation of the flat plate made of a plastically deformable material and rotating it, a complex vertical reflux can be generated, enabling even mixing of the fluid medium and thorough stirring, and the flow of the stirred flow can be adjusted. A twelfth embodiment of a stirring device equipped with the stirring body according to the present invention is illustrated below with reference to Figure 34. The flat plate 434 of the stirring body 433 provided in the stirring device 432 of this embodiment illustrated in Figure 34 is made of a plastically deformable material, and four notches 435 are formed to extend in a spiral shape around the center 436 by approximately 540 degrees, from the outer peripheral end 437 which is located inside the outer peripheral edge of the circular flat plate 434 and is provided at 90-degree intervals around the center 436 of the flat plate 434, toward the inner peripheral end 438 which is located near the center 436 and is provided at 90-degree intervals around the center 436. The blade portion 439 of the flat plate 434 has exactly the same shape as the blade portion 407C of the flat plate 403C shown in Figure 29, and the flat plate 434 shown in Figure 34 is the same as the flat plate 403C shown in Figure 29 except that it is provided with a bar magnet 440 on its outer circumference.

[0145] As illustrated in Figures 34(A) to 34(C), the stirring device 432 comprises a flat plate 434 of the stirring body 433, a shaft member 441 joined at the center 436 of the flat plate 434, a center cap 443 having a bearing 442, two side arm caps 444, a glass stirring tank 445 with a volume of liquid containing 500 mL and having three openings, and a magnetic stirring drive device 447 having a motor 446. Two bar magnets 440 are arranged around the center 436 of the flat plate 434 at 180-degree intervals and positioned on the outer periphery of the flat plate 434, and the shaft member 441, which is rotatably connected to the bearing 442, is joined to the center 436 of the flat plate 434, thereby forming the flat plate 434 of the stirring body 433 which has a constricted portion 439 as illustrated in Figure 34(A). Furthermore, the stirring tank 445 is airtightly sealed inside by O-rings provided on the center cap 443 and two side arm caps 444, and is positioned on the magnetic stirring drive device 447. The flat plate 434 of the stirring body 433 is sealed with polytetrafluoroethylene (registered trademark Teflon). Figure 34(A) schematically illustrates the movement of the stirred flow in the stirring tank 445 by the stirring device 432, in a state where multiple flows are generated, accompanied by large and small vortices, separating flows, vertical convection, circulating flows, and turbulence, as the motor 446 of the magnetic stirring drive device 47 is driven by predetermined physical means and the flat plate 434 of the stirring body 433, which is suspended in the stirring tank 445, rotates in the liquid.

[0146] According to the stirring device 432 equipped with the aforementioned stirring body 433, by joining the shaft member 441, which is rotatably connected to the bearing 442 in the center cap 443, to the central part 436 of the flat plate 434 equipped with a bar magnet 440 sealed with polytetrafluoroethylene (trademark name Teflon), and by driving the motor 446 provided in the magnetic stirring drive device 447 by predetermined physical means, the flat plate 434 of the stirring body 433, which is made of a plastically deformable material, can be rotated in the stirring tank 445 by magnetic force without contact with the drive unit of the magnetic stirring drive device 447. This provides a stirring blade and a stirring device equipped therewith, which can effectively stir the fluid medium without uneven mixing by generating a suction flow due to an attractive force generated from the upper surface near the outer periphery of the flat plate 434 toward the center of the flat plate 434, a suction flow due to an attractive force generated from the vicinity of the constricted portion toward the center of the flat plate 34, and a complex vertical return flow accompanied by multiple flows such as swirling flow and vertical convection in the liquid in the stirring tank 445, and can also adjust the flow of the stirring flow by appropriately forming deformation forms with different amounts of displacement by plastically deforming the flat plate 434 by predetermined physical means.Therefore, for example, if the flat plate 434, shaft member 441, bearing 442, center cap 443, side arm cap 444, and O-ring of the stirring body 433 are processed with polytetrafluoroethylene (trademark name Teflon), and the motor 446 provided in the magnetic stirring drive device 447 (magnetic stirrer) is driven by predetermined physical means, the flat plate 434 of the stirring body 433 equipped with a bar magnet 440 will rotate, causing an attractive flow in the liquid in the stirring tank 445 due to the attractive force generated from the upper surface near the outer circumference of the flat plate 434 toward the center of the flat plate 434, and a flow toward the center of the flat plate 434 from the vicinity of the constricted portion. The suction force generated by the suction and the complex vertical reflux involving multiple flows such as swirling flow and vertical convection allow for even and thorough mixing of the fluid medium. Furthermore, the flow of the stirring can be adjusted by plastically deforming the flat plate 434 by predetermined physical means to appropriately form deformation forms with different displacements and sealing them with polytetrafluoroethylene (registered trademark Teflon). Moreover, since seals like those found in direct-drive stirring devices are unnecessary, there is no contamination (bacterial contamination), and cleaning is easy. This allows the device to be used as a stirring blade, a magnetic stirring device equipped with it, and a spinner flask. However, the flat plate 434 equipped with the bar magnet 440 of the stirring body 433, the shaft member 441, the bearing 442, the center cap 443, the side arm cap 444, and the O-ring may be sealed with, for example, glass coating or polycarbonate, in addition to being processed with polytetrafluoroethylene (registered trademark Teflon), and the material and processing method of the flat plate 434 equipped with the bar magnet 440 of the stirring body 433, the shaft member 441, the bearing 442, the center cap 443, the side arm cap 444, and the O-ring are not particularly limited. Furthermore, the material that generates magnetization in the magnetic stirring drive device 447 provided in the stirring device 432 may be an electromagnet that generates magnetization electrically, in addition to a magnet, and the material that generates magnetization in the magnetic stirring drive device of the stirring body and the stirring device provided therewith according to the present invention is not particularly limited.

[0147] (Fourth embodiment of the stirring device) As shown in Figure 29, in the flat plate 403C of the stirring body 401C, the number of flat plates supported by the shaft member 408 is a single configuration. However, the number of flat plates in the stirring body according to the present invention may be other than one; for example, two or more flat plates may be combined. The number and configuration of the flat plates in the stirring body according to the present invention are not particularly limited. Figures 35 and 36 illustrate various embodiments of stirring blades equipped with the stirring body according to the present invention. Note that the circular stirring bodies 401E, 401F, 452, 455, 458, and 461 in the stirring blades 448, 450, 453, 456, and 459 illustrated in Figures 35 and 36 are made of a plastically deformable material and are exactly the same shape as any one of the stirring bodies 401A, 401B, 401C, and 401D shown in Figures 27 to 34, or any combination thereof, so a detailed explanation is omitted here.

[0148] As illustrated in Figure 35(A), the stirring blade 448 comprises a shaft member 449 having a U-shaped branch and stirring bodies 401E and 401F. The two branch sections of the shaft member 449 are arranged at 180-degree intervals around the center of the stirring bodies 401E and 401F, fixing the outer periphery of the stirring bodies 401E and 401F, and the stirring bodies 401E and 401F are arranged in a vertical column as shown in the figure. Note that the stirring bodies 401E and 401F have exactly the same shape as the stirring body 401C shown in Figure 29.

[0149] As illustrated in Figure 35(B), the stirring blade 450 comprises a shaft member 451 and a stirring body 452 formed by joining flat plates 403H and 403I at their outer circumferences. The shaft member 451 is joined to the center of the flat plate 403J, and as shown in the figure, the stirring body 452 is supported by the shaft member 451. The stirring body 452 has the exact same shape as the two stirring bodies 401C shown in Figure 29, which are joined at their outer circumferences.

[0150] As illustrated in Figure 36(A), the stirring blade 453 comprises a shaft member 454 having a U-shaped branch and a stirring body 455 in which two flat plates 403J and 403K are joined at their centers. The two branch sections of the shaft member 454 are provided at 180-degree intervals around the centers of the flat plates 403J and 403K, fixing the outer periphery of the flat plates 403J and 403K, thereby supporting the stirring body 455 with respect to the shaft member 454 as shown. The stirring body 455 has exactly the same shape as the two stirring bodies 401C shown in Figure 29, which are joined at their centers.

[0151] As illustrated in Figure 36(B), the stirring blade 456 comprises a shaft member 457 and a stirring body 458 formed by joining flat plates 403L and 403M at their outer circumferences. The shaft member 457 is joined to the center of the flat plate 403L, and as shown in the figure, the stirring body 458 is supported by the shaft member 457. The stirring body 458 has the exact same shape as the stirring body 401D shown in Figure 30 and the stirring body 401B shown in Figure 28, which are joined at their outer circumferences.

[0152] As illustrated in Figure 36(C), the stirring blade 459 comprises a shaft member 460 and a stirring body 461 in which a flat plate 403N is superimposed on the flat plate 403O and joined at their outer edges. The shaft member 460 is joined to the center of the flat plate 403N, and as shown in the figure, the stirring body 461 is supported by the shaft member 460. The flat plate 403N of the stirring body 461 has the exact same shape as the flat plate 403C of the stirring body 401C shown in Figure 29, and the flat plate 403O of the stirring body 461 has the exact same shape as the flat plate 403B of the stirring body 401B shown in Figure 28, scaled down by 30% at a 1:1 ratio.

[0153] Furthermore, in all of the aforementioned stirring bodies 401E, 401F, 452, 455, 458, and 461, the notches are formed so as not to come into contact with the outer edges of the stirring bodies 401E, 401F, 452, 455, 458, and 461.

[0154] According to the aforementioned agitators 401E, 401F, 452, 455, 458, and 461, multiple agitators made of plastically deformable material can be combined to form multiple different deformation forms through plastic deformation. Therefore, for example, if the agitators 401E, 401F, 452, 455, 458, and 461 of this embodiment are used in place of the agitator 417 of the agitator 415 shown in Figure 33, the agitators 401E, 401F, 452, 455, 458, and 461 will reciprocate, generating multiple flow types such as circulating flow and turbulent flow in the flow, enabling extremely complex and unsteady agitation of the fluid medium with low shear, and allowing the displacement of the agitators 401E, 401F, 452, 455, 458, and 461 to be adjusted through plastic deformation to appropriately form deformation forms and adjust the flow of the agitated flow. This provides easily manufactured agitator blade and an agitator equipped with it.

[0155] (Examples of cuts in the flat plate in the third and fourth embodiments of the stirring body) In the flat plate 403A of the stirring body shown in Figure 27, four spiral-shaped notches 402 are formed in the flat plate 403A, but the number and shape of the notches 402 are not particularly limited. Figure 37 illustrates embodiments of the flat plate of the stirring body according to the present invention with various notches. Note that the flat plates 464, 470, 476, and 484 of the stirring bodies 462, 468, 474, and 482 shown in Figure 37 are made of a plastically deformable material.

[0156] In the stirring body 462 illustrated in Figure 37(A), the spiral-shaped cutouts are represented as two slit-shaped cutouts 463. The two cutouts 463 are located inside the outer edge of a circular flat plate 464 having a wave-like shape formed by connecting a combination of arcs and straight lines in series. They are formed to spiral around the center 465, extending approximately 360 degrees from two outer peripheral ends 466 located 180 degrees apart around the center 465, toward two inner peripheral ends 467 located near the center 465 and also 180 degrees apart around the center 465.

[0157] In the stirring body 468 illustrated in Figure 37(B), the four notches 469, which are formed by connecting a combination of straight lines in series, are located on the inside near the corners of the outer edge of the square flat plate 470 and are provided at 180-degree intervals around the center 471. They extend in a square spiral shape around the center 471 for approximately 360 degrees, from four outer peripheral ends 472 located near the center 471 and provided at 90-degree intervals around the center 471.

[0158] In the stirring body 474 illustrated in Figure 37(C), four notches 475, which are formed by connecting a combination of arcs in series, extend from four outer peripheral ends 478 located near the outer edge of the regular hexagonal flat plate 476 and spaced 180 degrees apart around the center 477, to four inner peripheral ends 479 located near the center 477 and spaced 90 degrees apart around the center 477, spiraling approximately 360 degrees around the center 477 to the intermediate section 480. Starting from the intermediate section 480, the notches extend in the opposite direction to the spiral of the notches 475 extending from the outer peripheral ends 478 to the intermediate section 480, spiraling approximately 360 degrees around the center 477 towards the inner peripheral ends 479. Furthermore, six flaps 481 are formed on the outer periphery of the flat plate 476 by bending the outer edge of the flat plate 476 toward the center 477, starting from the dashed line shown in the figure.

[0159] In the stirring body 482 illustrated in Figure 37(D), two notches 483, formed by connecting a combination of arcs in series, are located on the inside near the outer edge of the elliptical flat plate 484 and are provided at 180-degree intervals around the center 485. These notches extend in a spiral shape around the center 485 by approximately 360 degrees from two outer peripheral ends 486 located near the center 485 and provided at 180-degree intervals around the center 485 to two inner peripheral ends 487 located near the center 485 and provided at 180-degree intervals around the center 485. Multiple circular through holes 488 are arranged within these notches.

[0160] According to the aforementioned agitators 462, 470, 474, and 482, if the spiral-shaped notches formed in the flat plate 462 are made into two slit-shaped cutouts 463, then, depending on the shape of the cutouts 463, the blade width, expansion / contraction movement width, and rotational movement width of the blade portion due to plastic deformation can be adjusted to form multiple deformation forms with different amounts of displacement, functioning as a variable adjustment structure for the flat plate. The wave-shaped flat plate 64 can generate multiple flows accompanied by multiple small vortices. Furthermore, the notches 469 formed in the square flat plate 470 are configured by connecting them in series with a combination of straight lines, thereby forming a spiral-shaped notch that conforms to the shape of the polygonal flat plate. Moreover, the notches 475, which are configured by connecting the flaps 481 on the flat plate 476 in series with a combination of right-handed and left-handed winding, can generate multiple flows accompanied by multiple large vortices. In addition, the multiple through holes 488 arranged in the elliptical flat plate 484 can generate multiple flows accompanied by multiple large and small vortices, and can also generate circulating flow even in high-viscosity liquids. As a result, for example, if the agitators 462, 470, 474, and 482 of this embodiment are used in place of the agitator 417 of the agitator 415 shown in Figure 31, a circulating flow can be generated even in high-viscosity and low-viscosity fluid media. This allows for extremely complex, unsteady stirring of the fluid medium with low shear, accompanied by various flows such as vortex, separation, suction, push-out, swirling, vertical convection, circulating flow, and turbulence in the liquid. Furthermore, the displacement of the flat plates 464, 470, 476, and 484 of the agitators 462, 470, 474, and 482 can be adjusted by plastic deformation to appropriately form the deformation shape and adjust the flow of the agitated flow. This provides easily manufactured agitator blades and an agitator equipped with them.

[0161] (13th embodiment of the stirring device) The fourth embodiment of the stirring body of the present invention comprises a flat plate having multiple spiral-shaped blade portions extending from the center by spiral-shaped notches that do not contact the outer circumference, and by appropriately forming deformation forms with different amounts of displacement by plastic deformation of the flat plate made of a plastically deformable material and fixing it in a pipe, it can be used as stirring blades for a stirring tank, i.e., a tubular mixer without a drive unit, that can mix and stir a fluid medium. Below, with reference to Figure 38, an example of a thirteenth embodiment of a stirring device equipped with the stirring body according to the present invention will be given. Note that the flat plates 403R and 403S of the stirring body 486 of this embodiment shown in Figure 38 are made of a plastically deformable material and have exactly the same shape as the flat plate 403C of the stirring body 401C shown in Figure 29, i.e., they are the same, so a detailed explanation will be omitted here.

[0162] As illustrated in Figures 38(A) and 38(B), the mixer 489 includes a stirring body 490 in which three-dimensional flat plates 403P and 403Q with constricted sections are joined at their centers, and a pipe 491 equipped with a flange. Because the stirring body 490 is joined inside the pipe 491, the mixer 489 can be airtightly connected to other pipes by screw fastening via gaskets or the like.

[0163] According to the mixer 489 equipped with the aforementioned agitator 490, by joining the agitator 490, which is made of flat plates 403P and 403Q made of a plastically deformable material joined at their centers, into the pipe 491, and flowing a fluid medium into the pipe 491 by predetermined physical means, a swirling flow with multiple separation vortices is generated in the fluid medium in the pipe 491, thereby uniformly mixing the fluid mediums to be mixed. Therefore, for example, by airtightly piping the aforementioned mixer 489 to an in-line fluid mixing device capable of fluid mixing multiple fluid mediums by screwing it in via a gasket, and driving a pump by predetermined physical means to flow the fluid medium into the pipe 91, the agitator 490 having a constricted portion generates a swirling flow with multiple separation vortices, thereby uniformly mixing the multiple fluid mediums to be mixed. Furthermore, it is possible to provide a tubular mixer, i.e., a static mixer, that does not have agitator blades and a drive unit equipped with them, which can atomize air bubbles in the liquid, thereby achieving labor saving, space saving, and energy saving. However, the fluid mixing performed by the mixer 489 in this embodiment is not limited to liquid-liquid mixing, but can also be gas-liquid mixing, mixing of soluble or insoluble substances, or high-viscosity or low-viscosity substances, and the fluid mixing performed by the mixer 489 in this embodiment is not particularly limited. Furthermore, the method of joining the mixer 489 in this embodiment to other pipes may be other than screw fastening, for example, welding, bonding, or fitting, and the method of joining the mixer 89 in this embodiment to other pipes is not particularly limited.

[0164] (14th embodiment of the stirring device) The stirring body according to the present invention comprises a flat plate made of an elastically deformable material, having multiple spiral-shaped blade portions extending from the center by spiral-shaped notches that do not contact the outer circumference, a support member that supports the outer circumference of the flat plate, and a movable member that supports the outer circumference and the center. The movable member reciprocates relative to the support member in a direction that brings the outer circumference and the center closer together and further apart from each other, thereby enabling unsteady stirring of the fluid medium. Furthermore, by vibrating the support member vertically, complex turbulence can be generated with extremely low shear, enabling even and uniform stirring of the fluid medium. Moreover, it can be used as a stirring blade in a stirring device that can adjust the flow of the stirred flow. Below, with reference to Figure 39, a 14th embodiment of a stirring device equipped with the stirring body according to the present invention is shown. Note that the flat plate 03 of the stirring body 02 provided in the stirring device 01 of this embodiment shown in Figure 39 is the same as the flat plate 3D of the stirring body 19 shown in Figure 4, so a detailed explanation is omitted here.

[0165] As shown in Figure 39, the stirring device 01 includes a stirring tank 04 with a volume of liquid of 300 mL, a stirring body 02 having a circular flat plate 03 with blades 016 made of an elastically deformable material, a movable member 05 and a support member 06, a top plate 07, a drive device 08 having a control device that can adjust the distance of movement of a brushless motor that reciprocates in the vertical direction, and a low-frequency vibration device 09 that vibrates up and down. By adjusting the position of the movable member 05, the low-frequency vibration device 09 vibrates up and down, and the support member 06 also vibrates up and down, causing the flat plate 03 to vibrate up and down while appropriately forming a deformed shape through elastic deformation. Furthermore, the three-dimensional flat plate 03 that forms the constricted wing portion 010A has the exact same shape as the flat plate 3C shown in Figure 3, and the three-dimensional flat plate 03 that has the dashed truncated cone-shaped wing portion 010B has the exact same shape as the flat plate 3B shown in Figure 2. The flat plate 03 with wing portion 010A shows the deformed form at approximately the uppermost position 011 of the range of motion in which the moving member 05 reciprocates, and the flat plate 03 with wing portion 010B shows the deformed form at approximately the lowermost position 012 of the range of motion in which the moving member 05 reciprocates.

[0166] As illustrated in Figures 39(A) and (B), in the stirring device 01, the top plate portion 07 has three through holes through which the movable member 05 and the support member 06 pass. One end of the two support members 06 is joined to the low-frequency vibration device 09 through the through hole in the top plate portion 07, and the other end is connected to the outer periphery, which is provided at 180-degree intervals around the center of the flat plate 03. In addition, one end of the movable member 05 is joined to the drive device 08 through the through hole in the top plate portion 07, and the other end is rotatably supported on the center 013 side of the flat plate 03 between two adjacent convex spherical shapes provided at the tip of the movable member 05, passing through a circular through hole in the center 011 of the flat plate 03. As a result, the two support members 06, which are the drive shafts of the low-frequency vibration device 09, vibrate up and down in the direction of arrow 014, causing the flat plate 03 to vibrate up and down. Additionally, the moving member 05, which is the drive shaft of the drive device 08, reciprocates in the direction of arrow 015, and the central side of the flat plate 03 reciprocates up and down, causing the flat plate 03 to elastically deform into a blade portion 010A with a constricted portion and a flat plate 03 with a frustoconical blade portion 010B, as illustrated in Figure 39(A). As a result, the flat plate 03 of the stirring device 01 vibrates up and down while appropriately forming a deformed shape through elastic deformation, and furthermore, the flat plate 03 vibrates up and down with dynamic behavior so that it repeatedly forms different deformed shapes in a reversible manner. The drive device 08 is equipped with a control device that adjusts the relative movement distance between the moving member 05 and the support members 06, and can move and reciprocate as appropriate within the distance of the movement range 017.

[0167] According to the stirring device 01 equipped with the aforementioned stirring body 02, by driving the drive devices 08 and 09 by predetermined physical means to appropriately move and reciprocate the moving member 05, the flat plate 03 made of an elastically deformable material undergoes elastic deformation, thereby allowing the flat plate 03 to vibrate up and down while being subjected to dynamic behavior that reversibly repeats the formation of different deformation forms, from a three-dimensional flat plate 03 having a frustoconical blade portion 010B to a three-dimensional flat plate 03 having a constricted blade portion 010A. As a result, in the liquid in the stirring tank 04, the flat plate 03 vibrates up and down, the moving member 05 reciprocates in the vertical direction, and multiple flows accompanied by vortices are generated around the blade portion 016 and in the gap between them. Furthermore, the center of the flat plate 03 moves up and down, generating vertical convection. Moreover, as the center of the flat plate 03 moves up and down, the constricted portion formed generates vortices due to separation flow. Furthermore, as the center of the flat plate 03 is lifted, a suction force rises from the bottom of the stirring tank 04 towards the center of the flat plate 03. By generating a pull flow, and further generating vortex and vertical convection as the suction flow converges and strikes the blade section 016 and the constricted section, and further generating a downward pushing flow and vertical convection as the center of the flat plate 03 is pulled down and the blade section 016 and the constricted section diffuse toward the bottom of the stirring tank 04, multiple flow types such as vortex, separation flow, suction flow, pushing flow, vertical convection, circulation flow, and turbulence are generated, enabling extremely complex and unsteady stirring of the fluid medium with low shear.Therefore, for example, if the material of the flat plate 03 of the stirring body 01 of the above embodiment is made of an elastically deformable material, and the drive devices 08 and 09 are driven by predetermined physical means to cause the moving member 05 and the support member 06 to reciprocate and vibrate up and down appropriately, the moving member 05 will reciprocate relative to the support member 06 in a direction that brings the outer periphery and the center of the flat plate 03 closer to and further away from each other, causing the blade portion 016 to twist and elastically deform with vertical expansion and contraction, rotation in forward and reverse rotation directions, and further diffusion and diffusion convergence movements, the flat plate 03 will By dynamically behaving in a way that repeatedly forms different deformation forms in a reversible manner, it is possible to perform extremely complex, unsteady stirring of a fluid medium with low shear, accompanied by multiple flow patterns such as vortex flow, separation flow, suction flow, push-out flow, swirling flow, vertical convection, circulation flow, and turbulence in the liquid. Furthermore, by controlling the reciprocating distance of the moving member 05 using a control device provided in the drive device 08, the flow of the stirring flow can be automatically adjusted by appropriately and reversibly forming deformation forms with different displacement amounts through elastic deformation of the flat plate 03. However, the configuration of the stirring device 01 that drives in multiple operating directions is not particularly limited; for example, the low-frequency vibration device 09 may be placed on the central side of the flat plate 03 and the drive device 08 on the outer periphery.

[0168] The notches in the flat plate of the stirring body according to the present invention described above may be formed by connecting arcs, straight lines, or combinations thereof in series, in addition to the algebraic spiral shape, and the shape of the notches in the flat plate of the stirring body according to the present invention is not particularly limited.

[0169] Furthermore, the cutting angle (i.e., the angle of the cut surface) of the notch in the flat plate of the stirring body according to the present invention described above may not be limited to a form in which the cut is perpendicular to the flat plate, but may also be a form in which the cut is made diagonally from the front side toward the center toward the back side, a form in which the cut is made diagonally from the front side toward the outer edge toward the back side, or even a curved form by curved surface processing or chamfering of the corners.

[0170] Furthermore, the direction in which the notches in the flat plate of the stirring body according to the present invention rotate and extend is not limited to the right-handed direction, but may also be, for example, the left-handed direction, or a combination of the right-handed and left-handed directions, and the direction in which the notches in the flat plate of the stirring body according to the present invention rotate and extend is not particularly limited.

[0171] The circumference angle of the notch formed around the center of the flat plate of the stirring body according to the present invention described above can be freely adjusted, and it is preferable to form it to rotate and extend in a range of about 180 degrees to about 1440 degrees, and in particular it is preferable to form it to rotate and extend in a range of about 360 degrees to about 720 degrees.

[0172] Furthermore, the number of notches in the flat plate of the stirring body according to the present invention can be freely set according to the purpose, preferably in the range of 2 to 100, and particularly preferably in the range of 2 to 10.

[0173] In addition to the one constricted portion and singularity formed by the flat plate of the stirring body according to the present invention described above, by appropriately adjusting the cuts and cutouts of the flat plate of the stirring body according to the present invention to form a deformed shape, two or more constricted portions and singularities can be formed, and the number of constricted portions and singularities formed by the flat plate of the stirring body according to the present invention is not particularly limited.

[0174] Furthermore, the amount of displacement of the deformation form formed by the flat plate of the stirring body according to the present invention can be freely adjusted, and it is preferable to adjust it in the range of 10% to 400% with respect to the diameter of the circle passing through the outer peripheral ends of the spiral notches, and particularly preferable to adjust it in the range of 25% to 150%.

[0175] Furthermore, the outer shape of the flat plate of the stirring body according to the present invention described above may be other than circular, for example, a polygon, an ellipse, an arc or a straight line, or a combination thereof connected in series, a flat plate bent to form a flap, or a combination of any of these, and can be freely formed according to the purpose.

[0176] The material for the flat plate of the stirring body according to the present invention, as described above, may be an elastically deformable material, but may also have properties such as flexibility, springiness, conductivity, ferromagnetism, biocompatibility, biodegradability, chemical resistance, heat resistance, oil resistance, seawater resistance, rust prevention, corrosion resistance, shape memory, or any combination thereof, and the properties of the material for the flat plate of the stirring body according to the present invention are not particularly limited.

[0177] The deformation form of the flat plate of the stirring body according to the present invention described above may be any deformation form other than the three-dimensional flat plate described above, as long as it can be reversibly formed by elastic deformation.

[0178] The configuration of the flat plate and movable member of the stirring body according to the present invention described above is not limited to the case where the flat plate is rotatably supported relative to the movable member, but may also be such that the flat plate is joined and supported relative to the movable member, for example.

[0179] Furthermore, the flat plate used in the stirring body and stirring apparatus equipped therewith, as described above, can be freely replaced with other types as long as they are flat plates of the stirring body and stirring apparatus equipped therewith, depending on the purpose, and the flat plate used in the stirring body and stirring apparatus equipped therewith, as described above, is not particularly limited.

[0180] In addition to stirring an object by combining the stirring body and the stirring device equipped therewith with a drive device as described above, the stirring body and the stirring device equipped therewith may also be used as a manual whisking device, for example, by providing a gripping part on the operating member (e.g., moving member or support member) of the stirring body and rotating and reciprocating the stirring body by hand to stir the object. As long as the stirring body and the stirring device equipped therewith are configured to stir the object, the configuration is not particularly limited.

[0181] The connection between the agitator according to the present invention described above and the drive unit and the operating member (e.g., movable member) of the agitator equipped therewith can be any method, other than joining the drive shaft of the drive unit to the operating member (movable member). For example, the operating member may be the drive shaft of the drive unit.

[0182] The drive device for the agitator and agitator equipped therewith according to the present invention described above may be a linear, Stirling, air, or magnetic motor, in addition to a brushless motor, and the drive device for the agitator and agitator equipped therewith according to the present invention described above is not particularly limited.

[0183] Furthermore, the drive operation of the stirring element and the stirring device equipped therewith according to the present invention described above may be reciprocating motion in the vertical direction, reciprocating rotation in forward and reverse rotation directions, rotation in one direction, or a combination of any of these, and the drive operation of the stirring element and the stirring device equipped therewith according to the present invention described above is not particularly limited.

[0184] Furthermore, the configuration of the stirring body and stirring apparatus equipped therewith according to the present invention described above is not limited to a configuration in which the flat plate and the working member (e.g., the moving member) are directly or via connecting members to the drive unit or the drive shaft of the drive unit. For example, the configuration may also be such that the flat plate and the working member (e.g., the moving member) are spaced apart from the drive unit or the drive shaft of the drive unit by a magnetic stirring device, and the configuration of the stirring body and stirring apparatus equipped therewith according to the present invention described above can be freely configured.

[0185] The container shape of the stirring tank of the stirring body and stirring apparatus equipped therewith according to the present invention described above may be, for example, an open or closed bioreactor, a closed flask with a screw cap, an open culture dish, or a vertically or horizontally elongated tubular shape, and the container shape of the stirring body and stirring apparatus equipped therewith according to the present invention described above is not particularly limited.

[0186] Furthermore, the volume of the stirring tank of the stirring body and stirring apparatus equipped therewith according to the present invention, as described above, may be other than 300 mL, for example, 150 mL, 500 mL, 1 L, 50 L, 100 L, 500 L, 1000 L, 2000 L, 1 t, 10 t, 100 t, 200 t, etc., and the volume of the stirring tank of the stirring body and stirring apparatus equipped therewith according to the present invention, as described above, is not particularly limited.

[0187] The features of the stirring body and stirring apparatus equipped therewith according to the present invention described above can be combined as appropriate.

[0188] The stirring body and stirring apparatus equipped therewith according to the present invention described above can be appropriately modified in various ways for the purpose, and such modifications are also included within the scope of the present invention, and the stirring body and stirring apparatus equipped therewith according to the present invention are not limited in any way.

[0189] Furthermore, the agitator and a stirring device equipped therewith according to the present invention described above can appropriately provide a physicochemical environment suitable for the proliferation and metabolism of cultured cells, differentiation and maturation of megakaryotic cells, multinucleation of megakaryotic cells, platelet production, and maintenance of physiological activity of platelets. For example, the agitator and a stirring device equipped therewith according to the present invention described above may be equipped with a ventilation device, exhaust device, temperature control device, pH control device, dissolved oxygen pressure adjustment device, baffle, sparger, port, etc., and used as a stirring culture device for stirring the culture medium and culturing cells. The physicochemical environment of the agitator and a stirring device equipped therewith according to the present invention described above is not particularly limited.

[0190] Furthermore, the objects cultured using the aforementioned stirring device and stirring culture apparatus according to the present invention may be anything other than megakaryocyte cells derived from human iPS cells, such as hematopoietic stem cells, stem cells, human iPS cells, human ES cells, and other cell-derived cells, as well as single-celled and multicellular organisms such as algae, seaweed, and Euglena (commonly known as Midorimushi). [Industrial applicability]

[0191] The stirring element and stirring apparatus equipped therewith are primarily used for stirring culture media in the pharmaceutical field, and for stirring, grinding, and mixing gases, liquids, powders, solids, gels, and mixtures of any combination thereof in fields such as food, beverages, animal feed, chemicals, cosmetics, paints, papermaking, petrochemicals, civil engineering, water treatment, energy, cell culture, and regenerative medicine. [Explanation of Symbols]

[0192] 1A stirring body 1B Stirring body 1C stirring body 2 cuts 3A flat plate 3B Flat plate 3C flat plate 3D flat plate 3E flat plate 3F flat board 3G flat plate 3H flat plate 3I flat plate 3J flat plate 3K flat plate 3L flat plate 4A Center 4B Center 4C Center 4D center 4E Center 4F Center 4G center 4H Center 4I Center 5. Outer edge 6A Inner circumference end 6B Inner circumference end 6C Inner circumference end 7A Blade section 7B Wing section 7C vane part 7D Blade section 7E Blade section 7F Wing section 7G blade section 7H Blade section 7I Blade section 7J Wing section 7K blade section 7L blade section 7M blade section 8. Movable member 9 Support members 11 Extended position 12 Extended position 13A Waist area 13B Waist area 15 Stirring device 16 Stirring tank 17. Movable member 18 Support Member 19. Expanding and contracting agitator 20 Top panel 21 stickers 22 Drive unit 24 Stirring device 25 Stirring tank 26 Plane plate 27 Moving member 28 Support member 29. Agitated body undergoing contraction 30 Top plate section 31 Bearings 32 bearings 33 gears 34 gears 35 Protection Department 36 Branching point 37 Drive unit 38 Drive unit 39A Blade section 39B Wing section 43 Movement range 44 Expandable and Expandable Agitator 45 Support member 46 Connecting plane plate 47 Movable member 48 Expandable and Expandable Agitator 49 Support member 50 Movement assist member 51 Movable member 52 Expandable and Expandable Agitator 53 Support member 54 Movable member 55 Expanding and contracting agitator 56 Support member 57 Connecting plane plate 58 Movable member 59 Expanding and contracting agitator 60 Support member 61 Connecting plane plate 62 Movement assist member 63 Moving member 64 Plane plate 65 Plane plate 66 Center 67 cuts 68 Outer edge 69 Inner circumferential end 70 Center 71A Flat plate auxiliary member 71B Flat plate auxiliary member 72 Plane plate 73 Center 74 Plane plate 75 Plane plate 76 Center 77 cuts 78 Outer edge 79 Inner Circumferential End 80 Flat plate auxiliary member 81 Internal shape 82 External shape 83 Plane plate 84 Center 85 Plane plate 86 Plane plate 87 Center 88 cuts 89 Outer edge 90 Inner circumference end 91 Flat plate auxiliary member 92 Internal shape 93 External shape 94 Plane plate 95 Center 96 Plane plate 97 clippings 98 Center 99 Outer edge 100 Inner circumference end 101 Plane plate 102 cuts 103 Center 104 Outer edge 105 Inner circumference end 106 Plane plate 107 cuts 108 Center 109 Outer edge 110 Inner circumference end 111 Middle section 112 Flap 113 Plane plate 114 cuts 115 Center 116 Outer edge 117 Inner circumference end 118 Through hole

Claims

1. A stirring device, A stirring body comprising a flat plate having multiple spiral-shaped blades extending from the center by spiral-shaped cuts, and an operating member that supports the flat plate, The stirring body comprises a drive device configured to move the operating member or the flat plate in the stirring body, and a stirring tank that houses the stirring body, The stirring device, A stirring device characterized in that either the operating member or the outer periphery of the flat plate is movable in a direction that moves relative to one another and in a direction that moves toward the other, and in conjunction with the movement in the direction that moves relative to one another, the blade portion rises up while moving away from the adjacent blade portion, and the flat plate extends to form a three-dimensional shape.

2. A gas stirring device, A stirring body comprising a flat plate having multiple spiral-shaped blades extending from the center by spiral-shaped cuts, and an operating member that supports the flat plate, The stirring body comprises a drive device configured to move the operating member or the flat plate in the stirring body, and a stirring tank that houses the stirring body, The stirring device, A gas stirring device characterized in that either the operating member or the outer periphery of the flat plate is movable in a direction that moves relative to it away from it and a direction that moves relative to it towards it, and in conjunction with the movement in the direction that moves relative to it away from it, the blade portion rises up while moving away from the adjacent blade portion, and the flat plate extends to form a three-dimensional shape.

3. A gas mixing device, A stirring body comprising a flat plate having multiple spiral-shaped blades extending from the center by spiral-shaped cuts, and an operating member that supports the flat plate, The stirring body comprises a drive device configured to move the operating member or the flat plate in the stirring body, and a stirring tank that houses the stirring body, The stirring device, A gas mixing apparatus characterized in that either the operating member or the outer periphery of the flat plate is movable in a direction that moves relative to one another and in a direction that moves toward the other, and in conjunction with the movement in the direction that moves relative to one another, the blade portion rises up while moving away from the adjacent blade portion, and the flat plate extends to form a three-dimensional shape.

4. The stirring device according to claim 1, The notch in the stirring body is A stirring device characterized by being formed by connecting arcs, straight lines, or combinations thereof in series.

5. The stirring device according to claim 1, The drive device is A stirring device characterized in that, in addition to the aforementioned movement, it is configured to rotate the operating member or the flat plate.

6. A stirring device according to any one of claims 1, 4, or 5, The stirring device, In the three-dimensional shape formed by the elongation of the flat plate, one or more constrictions are formed. A stirring device characterized by the following features.

7. A stirring device according to any one of claims 1, 4, and 6, The stirring device, In the three-dimensional shape formed by the elongation of the flat plate, the wing portion is formed into a plurality of wave-like shapes in which the front and back surfaces are exposed when viewed from one direction. A stirring device characterized by the following features.

8. A stirring device according to any one of claims 1, 4, to 7, A stirring device further comprising a low-frequency vibration device configured to vibrate the aforementioned flat plate vertically.

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