Color-fixing composition for contact lenses, contact lenses, and method for manufacturing the same.

Abstract

To provide a color fixing composition for contact lenses with pearlescence.SOLUTION: A color fixing composition for contact lenses with pearlescence is provided, comprising a pearlescent powder and an adjuvant. The adjuvant contains at least two of the followings: alcohols, amines, ketones, alkenes, esters, resins, polyamides, celluloses, polyacids, ammonium salts, phosphoric acids, alkene acids, or silanes, so that the pearlescent powder stably adheres to a lens to form a pattern layer.SELECTED DRAWING: Figure 1

Description

Technical Field

[0004] ""

[0001] The present disclosure relates to a color stop composition, contacts and a method for manufacturing the same, and particularly to a color stop composition, contacts and a method for manufacturing the same for contacts having a pearly color tone.

Background Art

[0002] As contact lenses become increasingly popular, the comfort of wearing contact lenses is being increasingly emphasized by wearers. Contact lenses made of hydrogel have excellent moisturizing functions, so that even when worn for a long time, the cornea can be sufficiently hydrated, and it is difficult to cause uncomfortable eye symptoms due to corneal dryness. Therefore, hydrogel has become one of the preferred components of contact lenses. In addition, silicone hydrogel contact lenses contain siloxane compounds and thus have high oxygen permeability. Sufficient oxygen can directly contact the cornea through the lens, allowing the cornea to contain sufficient oxygen. As a result, even when worn for a long time, silicone hydrogel contact lenses are less likely to cause uncomfortable eye sensations due to insufficient oxygen in the cornea.

Summary of the Invention

Problems to be Solved by the Invention

[0003] In addition to wearing comfort, contact lenses are also increasingly valued by wearers for their ability to display an effect of glittering and changing color after wearing. Such contact lenses can be designed with special patterns and glittering effects for the iris and sclera. However, the method for manufacturing pigments that bring about a glittering and color-changing appearance effect has problems with the stability and safety of the pigments in the contact lens body. Therefore, the conventional technology needs to be improved.

Means for Solving the Problems

[0004] One embodiment of the present disclosure provides a color-fixing composition for contact lenses comprising a pearl toner and an auxiliary agent containing at least two of the following: alcohols, amines, ketones, alkenes, esters, resins, polyamides, celluloses, polybasic acids, ammonium salts, phosphoric acids, olefinic acids, or silanes.

[0005] In some embodiments, the auxiliary agent further comprises a solvent containing alcohols, amines, ketones, alkenes, esters, or combinations thereof; a thickener containing polyacrylic acid resins, polymethacrylic acid resins, polystyrene resins and their derivatives, polyamides, or combinations thereof; a hydrophilic polymer containing polyvinyl alcohol, cellulose and its derivatives, polyethylene glycol, polyvinylpyrrolidone and its copolymers, hydroxyapatite, or combinations thereof; and a dispersant containing polybasic acids, ammonium salts, phosphoric acids, olefinic acids, silanes, or combinations thereof.

[0006] In some embodiments, polybasic acids include polycarboxylic acids; ammonium salts include alkyl trimethyl benzyl ammonium salt, dialkyl dimethyl ammonium salt, or alkyl ammonium salt; phosphoric acids include phosphoric acid esters, trisodium phosphate, or sodium pyrophosphate; olefinic acids include acrylic esters or ethylene glycol dimethacrylate; and silanes include vinyltrimethoxysilane, triethoxyvinylsilane, or vinyltriisopropoxyvinylsilane.

[0007] In some embodiments, the pearl toner includes a matrix containing mica, calcium aluminum borosilicate, alumina, or silicon dioxide, with the surface of the matrix coated with titanium dioxide, iron oxide, tin oxide, or a combination thereof. For example, to produce a pearlescent effect, the surface of the matrix is ​​coated with titanium dioxide, iron oxide, tin oxide, or a combination thereof.

[0008] In some embodiments, if the total weight of the color-fixing composition is 100%, the weight percentage of pearl toner is 5% to 40%, and the weight percentage of auxiliary agents is 60% to 95%.

[0009] In some embodiments, the color-fixing composition further comprises an inorganic toner, an organic toner, or a combination thereof.

[0010] In some embodiments, the inorganic toner includes titanium dioxide toner, titanium phenol toner, iron oxide toner, or a combination thereof.

[0011] In some embodiments, if the total weight of the color-fixing composition is 100%, the weight percentage of pearl toner is 15% to less than 40%, the weight percentage of inorganic toner is 1% to 20%, and the weight percentage of auxiliary agents is 40% to 85%.

[0012] In some embodiments, the organic toner includes bisazo toners, monoazo toners, phthalocyanine toners, triphenodioxazine toners, or combinations thereof.

[0013] In some embodiments, if the total weight of the color-fixing composition is 100%, the weight percentage of pearl toner is 15% to 40%, the weight percentage of organic toner is 1% to 4%, and the weight percentage of auxiliary agents is 40% to 85%.

[0014] In some embodiments, if the total weight of the color-fixing composition is 100%, the weight percentage of pearl toner is 10% to 30%, the weight percentage of inorganic toner is 1% to 30%, the weight percentage of organic toner is 1% to 4%, and the weight percentage of auxiliary agents is 40% to 85%.

[0015] Another embodiment of the present disclosure provides a method for manufacturing a pearlescent lens, comprising the steps of: providing a color-fixing composition as described above; filling a template with the color-fixing composition to form a colloidal layer; transferring the colloidal layer into a first mold and forming a pattern layer after curing; injecting the composition into the first mold to cover the pattern layer; and curing the pattern layer and the composition to form a pearlescent lens.

[0016] In some embodiments, the composition comprises a hydrogel or a silicone hydrogel.

[0017] In some embodiments, the process further includes the step of injecting the composition into a first mold to cover the pattern layer, followed by the step of clamping the second mold and the first mold together.

[0018] In some embodiments, the pattern layer corresponds to the iris, sclera, or a combination thereof.

[0019] In some embodiments, the pattern layer is a random pattern.

[0020] In some embodiments, the pattern layer is a non-random pattern.

[0021] In some embodiments, the step of curing the pattern layer and composition includes curing the pattern layer and composition with ultraviolet light or heat.

[0022] This contact lens comprises a lens body and a pattern layer formed by curing the aforementioned color-fixing composition, the pattern layer being coated on the lens body and having a pearlescent tint.

[0023] In some embodiments, the pattern layer corresponds to the iris, sclera, or a combination thereof. [Brief explanation of the drawing]

[0024] Various aspects of the present disclosure will be most readily understood by reading the following detailed description while referring to the drawings. It should be noted that, based on the standard operating regulations in the industry, various feature structures may not be drawn proportionally. In fact, for the clarity of the discussion, the sizes of various feature structures can be arbitrarily increased or decreased. To make the above and other objects, features, advantages, and examples of the present disclosure clearer and more understandable, the drawings are described as follows. [Figure 1] It is a flowchart showing a method for manufacturing a lens with a pearly color tone according to an embodiment of the present disclosure.

Modes for Carrying Out the Invention

[0025] To make the description of the present disclosure more detailed and complete, the embodiments and specific examples of the present disclosure are presented in the following explanatory description, but this is not the only form for implementing or operating the specific examples of the present disclosure. Each of the examples disclosed below may be combined or replaced with each other if beneficial, or other examples may be added to one example without further description or explanation. In the following description, many specific details are elaborated to enable the reader to fully understand the following examples. However, the embodiments of the present disclosure may be implemented without such specific details.

[0026] Also, spatial relative terms such as "lower", "upper", etc. are for easily explaining the relative relationship in the drawing between one element or feature and another element or feature. These spatial relative terms are intended to include different orientations of the device during use or operation in addition to the orientation shown in the figure. The device may be arranged separately (e.g., rotated 90 degrees or in other directions), and the spatial relative descriptions used herein may be interpreted accordingly.

[0027] In this specification, "one" and "the" may refer to one or multiple items, unless otherwise specifically limited with respect to articles in a sentence. To further understand, as used herein, "includes," "possesses," "has" and similar words refer to the features, regions, integers, processes, operations, elements and / or components described therein, but do not exclude one or more other features, regions, integers, steps, operations, elements, components and / or groups thereof described or added therein.

[0028] The following examples and experimental examples illustrate in more detail the color-fixing composition for pearlescent contact lenses and the method for manufacturing contact lenses of this disclosure. However, these are for illustrative purposes only and are not intended to limit this disclosure. The scope of protection of this disclosure shall be defined by the claims attached thereto.

[0029] In this specification, "pearlescent hue" may include not only pearlescent luster but also various metallic hues or the shimmering luster of gemstones. For example, gemstone gold in pearl toner exhibits a golden, gemstone-like pearlescent luster; carbon black in pearl toner exhibits a black pearlescent luster; black in pearl toner exhibits a blackish-gray pearlescent luster; silver white in pearl toner exhibits a silvery-white pearlescent luster; gold in pearl toner exhibits a golden pearlescent luster; light gold in pearl toner exhibits a light gold pearlescent luster; red / copper / gold in pearl toner exhibits a peach-purple pearlescent luster; brown in pearl toner exhibits a copper-brown pearlescent luster; purple in pearl toner exhibits a light purple pearlescent luster; dark purple in pearl toner exhibits a dark purple pearlescent luster; or blue in pearl toner exhibits a blue pearlescent luster.

[0030] This disclosure describes a method for stably adhering pearl toner to the colored layer of a lens using a color-fixing system, thereby enhancing safety during wear, and also exhibiting a specific pattern and color through the color-fixing composition.

[0031] In some embodiments, the color-fixing composition includes a pearl toner and an auxiliary agent.

[0032] Pearl Toner

[0033] In some embodiments, pearl toners include mica, titanium dioxide, silicon dioxide, iron oxide, alumina, aluminum calcium borosilicate, tin oxide, similar materials, or combinations thereof. More specifically, pearl toners, also known as pearl pigments, are formed primarily by coating a substrate with an oxide. The thickness and proportion of the oxide coating affect the color, and different combinations of substrates and oxides produce different gloss and effects.

[0034] In some embodiments, the substrates can be classified as follows:

[0035] 1. Natural Base Material - Mica: Natural mica is a natural mineral used as a base material for pearl toner. Due to its chemical and mechanical properties, it is suitable as a base material for glossy toner.

[0036] 2. Synthetic Substrates: The effects provided by synthetic substrates are primarily based on precise control of chemical purity and particle shape during the manufacturing process. Characteristics of synthetic substrates include a smooth and regular surface and a pure white powder color. In one example, synthetic mica (synthetic fluorphlogopite) exhibits high brightness characteristics in addition to having a pure white powder color, due to the precise control of the substrate and toner.

[0037] 3. Silicon Dioxide: The synthesized silicon dioxide sheet has a very uniform thickness distribution, with each sheet being the same thickness. The characteristic of toner made from such a substrate is that it can refract different colors (i.e., interference colors) depending on the angle.

[0038] 4. Sheet-shaped alumina: Alumina sheets can provide a special luminous effect. Alumina substrates exhibit a crystal-like sparkle due to their narrow pearl particle size distribution (5 micrometers to 40 micrometers) and high surface light reflectivity. Alumina substrates have a distinct pure white hue, which is advantageous for incorporating a silvery-white interference color effect.

[0039] 5. Calcium Boron-Aluminum Silicate: Calcium boron-aluminum silicate is a base material that achieves a pure and brilliant color effect. Pearlescent luster based on such a base material provides bright colors with high transparency.

[0040] 6. Bismuth Oxychloride: Bismuth oxychloride exhibits different pearlescent luster effects depending on its aspect ratio and crystal size. Bismuth oxychloride displays a silvery-white pearlescent luster.

[0041] In some embodiments, the pearl toner includes mica, titanium dioxide, silicon dioxide, iron oxide, alumina, aluminum calcium borosilicate, tin oxide, similar substances, or combinations thereof. In some examples, the pearl toner contains 47-73% aluminum calcium borosilicate (Cas No: 65997-17-3), 8-18% silicon dioxide (Cas No: 7631-86-9), 16-26% titanium dioxide (Cas No: 13463-67-7), 3-7% iron oxide, and <2% tin oxide (Cas No: 18282-10-5); 46-54% iron oxide (Cas No: 1317-61-9), 36-50% mica (Cas No: 12001-26-2), and 4-10% titanium dioxide (Cas No: 13463-67-7); 55-70% iron oxide (black iron oxide 54-70% (Cas No: 1317-61-9) and <1% red iron oxide (Cas Cas No: 1309-37-1), alumina 27-45% (Cas No: 1344-28-1), and silicon dioxide <3% (Cas No: 7631-86-9); synthetic mica (fluorphlogopite) 75-88% (Cas No: 12003-38-2), titanium dioxide 11-21% (Cas No: 13463-67-7), and tin oxide 1-4% (Cas No: 18282-10-5); mica 72-84% (Cas No: 12001-26-2), titanium dioxide 12-19% (Cas No: 13463-67-7), iron oxide 4-8% (Cas No: 1309-37-1), and tin oxide <1% (Cas No:18282-10-5); Calcium aluminum borosilicate 66-81% (Cas No:65997-17-3), silicon dioxide 2-6% (Cas No:7631-86-9), titanium dioxide 17-27% (Cas No:13463-67-7), and tin oxide <1% (Cas No:18282-10-5); Titanium dioxide 33-44% (Cas No:13463-67-7), silicon dioxide 30-40% (Cas No:7631-86-9), mica 15-37% (Cas No:12001-26-2), and tin oxide <1% (Cas No:18282-10-5); mica 60-68% (Cas No: 12001-26-2) and 32-40% iron oxide (Cas No: 1309-37-1);Titanium dioxide 49-59% (Cas No: 13463-67-7), silicon dioxide 12-16% (Cas No: 7631-86-9), and mica 25-39% (Cas No: 12001-26-2); silicon dioxide 81-90% (Cas No: 7631-86-9), titanium dioxide 8-14% (Cas No: 13463-67-7), and tin oxide 2-5% (Cas No: 18282-10-5); titanium dioxide 29-39% (Cas No: 13463-67-7), silicon dioxide 29-37% (Cas No: 7631-86-9), mica 23-42% (Cas No: 12001-26-2), and tin oxide <1% (Cas Includes No: 18282-10-5).

[0042] Supplement

[0043] In some embodiments, the auxiliary agent includes a solvent, a thickener, a hydrophilic polymer, and a dispersant.

[0044] In some examples, the solvent includes, but is not limited to, one or more combinations of alcohols, amines, ketones, alkenes, and esters. For example, the solvent includes ethanol, glycerin, diethylene glycol, N-methylpyrrolidone, dimethylacetamide, and dimethylformamide. When the total weight of the auxiliary agent is taken as 100%, the solvent content is between 30 and 90 wt%, for example, 30 wt%, 35 wt%, 40 wt%, 45 wt%, 50 wt%, 55 wt%, 60 wt%, 65 wt%, 70 wt%, 75 wt%, 80 wt%, 85 wt%, 90 wt%, or any value between any two of these values.

[0045] In some examples, the thickener includes, but is not limited to, resins. For example, the thickener includes one or more combinations of polyacrylate, polymethacrylate, polystyrene and its derivatives, and polyamide. The content of the thickener is between 1% and 60%, for example, between 15% and 50%, for example, 15wt%, 20wt%, 25wt%, 30wt%, 35wt%, 40wt%, 45wt%, 50wt%, or any value between these two. If the thickener content is less than 1%, the viscosity properties of the color-fixing composition are adversely affected, and it may not be able to adhere to a specific position on the lens body. If the thickener content exceeds 60%, the color-fixing composition may be too viscous, which may adversely affect the contact lens manufacturing process.

[0046] In some examples, the hydrophilic polymer includes, but is not limited to, polyvinyl alcohol, cellulose and its derivatives, polyethylene glycol, polyvinylpyrrolidone and its copolymer, hydroxyapatite, or a combination of one or more of the above. For example, polyvinyl alcohol may be a polymer with a degree of polymerization between 500 and 10,000. Cellulose may have a molecular weight between 5,000 and 500,000. Polyethylene glycol may have a molecular weight between 500 and 500,000. Polyvinylpyrrolidone may have a molecular weight between 5,000 and 1,500,000. The content of the hydrophilic polymer is between 1 and 45%, for example, between 5 and 40%. If the hydrophilic polymer content of the color-fixing composition is less than 1%, its viscosity properties are negatively affected, preventing it from adhering to specific positions on the lens body. If the hydrophilic polymer content exceeds 45%, the viscosity becomes too high, which can negatively impact the contact lens manufacturing process. The hydrophilic polymer content also affects the comfort of wearing the contact lens.

[0047] In some examples, the dispersant includes, but is not limited to, polybasic acids, ammonium salts, phosphoric acids, olefinic acids, silanes, or combinations thereof. Exemplarily, the dispersant includes at least selectively addable polybasic acids, ammonium salts, phosphoric acids, olefinic acids, silanes, or combinations thereof, where the polybasic acids are polycarboxylic acids, the ammonium salts are alkyltrimethylbenzylammonium salts, dialkyldimethylammonium salts, or alkylammonium salts, the phosphoric acids are phosphoric acid esters, trisodium phosphate, or sodium pyrophosphate, the olefinic acids are acrylates or ethylene glycol dimethacrylates, and the silanes are vinyltrimethoxysilane, triethoxyvinylsilane, or vinyltriisopropoxysilane, or one or more combinations thereof.

[0048] Manufacturing of color-fixing compositions

[0049] In some embodiments, the pearl toner and the auxiliary agent are mixed. For example, the pearl toner and the auxiliary agent are thoroughly stirred and mixed to obtain a color-fixing composition. In some examples, the weight percentage of the pearl toner is 5% to 40%, and the weight ratio of the auxiliary agent is 60% to 95%, so that the color-fixing composition remains fluid without solidifying. For example, the weight percentage of the pearl toner is 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, or any value between these two. The weight ratio of the auxiliary agent is 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or any value between these two.

[0050] In some embodiments, a pearl toner, an inorganic toner, and an auxiliary agent are mixed. The inorganic toner includes, but is not limited to, titanium dioxide toner, titanium phenol toner, or iron oxide toner. In some embodiments, the weight percentage of pearl toner is 15% to less than 40%, the weight percentage of inorganic toner is 1% to 20%, and the weight percentage of auxiliary agent is 40% to 84%. For example, the weight percentage of pearl toner may be 15%, 20%, 25%, 30%, 35%, 40%, or any value between these two; the weight percentage of inorganic toner may be 1%, 2%, 3%, 4%, 5%, 7%, 10%, 15%, 20%, or any value between these two; and the weight percentage of auxiliary agents may be 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 84%, or any value between these two. At these weight ratios, the color-fixing composition remains fluid without solidifying.

[0051] In some embodiments, a pearl toner, an organic toner, and an auxiliary agent are mixed. The organic toner includes, but is not limited to, bisazo toners, monoazo toners, or phthalocyanine toners. In some examples, the weight percentage of the pearl toner is 15% to 40%, the weight percentage of the organic toner is 1% to 4%, and the weight percentage of the auxiliary agent is 56% to 84%. For example, the weight percentage of the pearl toner is 15%, 20%, 25%, 30%, 35%, 40%, or any of these values; the weight percentage of the organic toner is 1%, 2%, 3%, 4%, or any of these values; and the weight percentage of the auxiliary agent is 56%, 60%, 65%, 70%, 75%, 80%, 84%, or any of these values. At such weight ratios, the color-fixing composition remains fluid without solidifying.

[0052] In some embodiments, a pearl toner, an inorganic toner, an organic toner, and an auxiliary agent are mixed. The inorganic toner includes, but is not limited to, titanium dioxide toners, titanium phenol toners, or iron oxide toners. The organic toner includes, but is not limited to, bisazo toners, monoazo toners, or phthalocyanine toners. In some examples, the weight percentage of pearl toner is 10% to 30%, the weight percentage of inorganic toner is 1% to 30%, the weight percentage of organic toner is 1% to 4%, and the weight percentage of auxiliary agent is 40% to 85%. For example, the weight percentage of pearl toner may be 10%, 15%, 20%, 25%, 30%, or any value between these two; the weight percentage of inorganic toner may be 1%, 2%, 3%, 4%, 5%, 7%, 10%, 15%, 20%, 25%, 30%, or any value between these two; the weight percentage of organic toner may be 1%, 2%, 3%, 4%, or any value between these two; and the weight percentage of auxiliary agents may be 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, or any value between these two. At these weight ratios, the color-fixing composition remains fluid without solidifying.

[0053] Contact lens

[0054] In some embodiments, the lens structure of a contact lens comprises a lens body manufactured from a composition consisting primarily of silicone hydrogel and / or hydrogel, and can be primary molded by die casting, but is not limited to this disclosure. In some embodiments, the hydrogel can enhance wearing comfort by improving the wettability and surface lubricity of the lens body. Suitable hydrogels may be low-water-content (water content less than 50 weight percent) nonionic polymers classified as Group 1 by the FDA, including Helfilcon A & B, Hioxifilcon B, Mafilcon, Polymacon, Tefilcon, and Tetrafilcon A. Suitable hydrogels may be high-water-content (water content greater than 50 weight percent) nonionic polymers classified as Group 2 by the FDA, including Acofilcon A, Alfafilcon A, Hilafilcon B, Hioxifilcon A, Hioxifilcon B, Hioxifilcon D, Nelfilcon A, Nesofilcon A, Omafilcon A, and Samfilcon A. Suitable hydrogels may also be low-water-content (water content less than 50 weight percent) ionic polymers classified as Group 3 by the FDA, including Deltafilcon A. Suitable hydrogels may be high-water-content (water content exceeding 50 weight percent) ionic polymers classified as Group 4 by the FDA, including Etafilcon A, Focofilcon A, Methafilcon A, Methafilcon B, Ocufilcon A, Ocufilcon B, Ocufilcon C, Ocufilcon D, Ocufilcon E, Phemfilcon A, and Vifilcon A.

[0055] In some embodiments, silicone hydrogels can prevent corneal oxygen deficiency by increasing the oxygen permeability of the lens body. Suitable silicone hydrogels may be materials classified as Group 5 by the U.S. Food and Drug Administration (FDA), including Balafilcon A, Comfilcon A, Efrofilcon A, Enfilcon A, Galyfilcon A, Lotrafilcon A, Lotrafilcon B, Narafilcon A, Narafilcon B, Senofilcon A, Delefilcon A, and Somofilcon A. Other beneficial components, such as blue light or UV absorbers, may be added to the lens body as needed.

[0056] How to manufacture lenses with a pearlescent finish

[0057] Refer to Figure 1, a flowchart illustrating a method for manufacturing a pearlescent tinted lens according to one embodiment of the present disclosure. Method 100 for manufacturing a pearlescent tinted lens includes step 102, in which a color-fixing composition is filled into patterned grooves of a template to form a colloidal layer. In some embodiments, the color-fixing composition is filled into patterned grooves of a template and, after a certain period of time, forms a colloidal layer within the patterned grooves. In some embodiments, the template may be a steel plate and its patterned grooves may be formed by laser engraving, but the present disclosure is not limited thereto. In step 104, the colloidal layer is transferred into a first mold (e.g., a matrix or concave mold) and cured to form a pattern layer. In some embodiments, this colloidal layer is transferred into the matrix under appropriate pressure. In some embodiments, if the pattern layer uses more than one color, i.e., if the pattern layer contains multiple color layers, it may be necessary to perform the transfer process multiple times with more than one template. In some embodiments, curing includes ultraviolet (UV) curing or thermal curing. In step 106, the composition is injected into the first mold to coat the pattern layer. For example, a fixed amount of the composition (containing silicone hydrogel or hydrogel) is injected into a concave mold. In step 108, the first mold is clamped together with a second mold (e.g., a male or convex mold). For example, the male mold is placed above the master mold. In step 110, the pattern layer and composition are cured to form a lens with a pearlescent tint. In some embodiments, the pattern layer and composition in the clamped first and second molds are cured with ultraviolet (UV) light for about 10-15 minutes, and the composition further comprises a photoinitiator containing, but not limited to, benzoin methyl ether, 1-hydroxycyclohexyl phenyl ketone, Darocur-R1173, or Irgacure-R-819. In some embodiments, the pattern layer and composition in the clamped first and second molds are cured by heat, for example, by heating in an oven.The composition further comprises a thermal initiator containing, but not limited to, 2,2-azobis(2,4-dimethylvaleronitrile), 2,2-azobis(2-methylpropionitrile), or 1,1-azobis(cyanocyclohexane). Step 112 is used to release the pearlescent lenses. Step 114 is used to hydrate the pearlescent lenses by immersing them in water. Step 116 is used to seal the pearlescent lenses in a package containing a packaging solution, and then sterilize the sealed package.

[0058] Examples

[0059] Example 1: Color-fixing composition having pearl toner and auxiliary agent

[0060] 1.1 Detection of the fluidity of the color-fixing composition

[0061] We offer 11 types of pearl toner, all expressed in weight percentage (wt%), as follows: [Table 1-1] [Table 1-2]

[0062] The pearl toners 1 to 11 were each mixed with an auxiliary agent by uniform stirring for 1 hour to form recipes 1.1 to 1.11. The pearl toner accounted for 22 wt%, the auxiliary agent for 88 wt%, and if the auxiliary agent is considered as 100%, the solvent (glycerin 5 wt%, diethylene glycol 5 wt%, water 30 wt%) totaled 40 wt%, the thickener (including acrylic resin 25 wt%, polymethacrylic acid resin 20 wt%) totaled 45 wt%, the hydrophilic polymer contained polyethylenepyrrolidone 10 wt%, and the dispersant (including polycarboxylic acid 3 wt%, alkylammonium salt 2 wt%) totaled 5 wt%. Within 4 hours after the start of mixing, the fluidity defects such as solidification and semi-solidification were visually observed in recipes 1.1 to 1.11 (color-fixing compositions).

[0063] As can be seen from the results (not shown), all of the above 11 types of color-fixing compositions (inks) exhibit fluidity after placement, and there are no problems with poor fluidity.

[0064] 1.2 Physical Size and Detection of Elution

[0065] After transferring the above recipes 1.1 to 1.11 onto the lens body (refer to the above manufacturing method, the material is hydrogel, and a detailed explanation is omitted here), the lens was washed with pure water to remove inorganic salts and solvents. The lens was dried at 105°C for 17 hours, and the weight of the sample piece (m1) was recorded. The dried lens was placed in cylindrical filter paper, placed in a Soxhlet extraction tube, and an extraction solvent (e.g., water or n-hexane) was added to a round-bottom flask, followed by heating, boiling, and extraction for 4 hours. After extraction, the lens was dried at 105°C for 17 hours, and the weight of the sample piece (m2) was recorded. Calculation of elution value: [(m1-m2) / m1] × 100%. Judgment criterion: The elution of either water or n-hexane must be <1%. [Table 2]

[0066] As can be seen from Table 2 above, meeting the physical size standards means that the contact lenses with a pearlescent tint will not deform after manufacturing is complete. Furthermore, since the lenses transferred with the above-mentioned multiple color-fixing compositions exhibit less than 1% elution of water or n-hexane, the color-fixing compositions (inks) do not leach from the lenses, ensuring safety.

[0067] 1.3 Colorfastness Test

[0068] After transferring the above recipes 1.1 to 1.11 onto the lens body (refer to the above manufacturing method, the material is hydrogel, and a detailed explanation is omitted here), the lens body of recipes 1.1 to 1.11 was filled with preservation solution using a cotton swab. Next, the underside of the cotton swab was wiped 10 times from the photocenter outwards of the lens body, and the presence or absence of staining of the cotton swab was visually checked, as well as the condition of the lens pattern. The criterion for judgment was to visually observe the cotton swab, and if the cotton swab was stained, it was judged as color fading.

[0069] As can be seen from the results (not shown), the cotton swabs used to wipe the lens body in recipes 1.1 to 1.11 all showed no discoloration or color fading, indicating that all passed the colorfastness test. Therefore, the color-fastening composition is safe and has excellent color-fastening ability during the manufacturing process in which it is transferred to the lens body.

[0070] 1.4 Detection of Cytotoxicity

[0071] Cytotoxicity is one of the biocompatibility assessment methods that evaluates the reaction of the human body to medical devices or biomaterials when they come into indirect or direct contact with the human body. Both the experimental method and operating procedures must refer to the ISO 10993-5 standard. Cell viability analysis (MTT assay) was performed to analyze cell activity 24 hours after the addition of the test substance, and the cell viability was greater than 70%, indicating no toxicity. [Table 3]

[0072] As can be seen from Table 3 above, lenses transferred with the above-mentioned multiple color-fixing compositions all exhibited a cell viability rate >70%. Therefore, lenses transferred with the above-mentioned multiple color-fixing compositions are non-toxic and safe.

[0073] Example 2: Color-fixing composition having pearl toner, inorganic toner and / or organic toner and auxiliary agent

[0074] Twenty color-fixing compositions are provided, each consisting of a pearl toner, an inorganic toner and / or an organic toner, and an auxiliary agent. The manufacturing method is similar to that of Example 1, and the pearl toner, inorganic toner and / or organic toner and auxiliary agent (same as in Example 1) were uniformly stirred and mixed for 1 hour at the weight percentages (wt%) shown in Table 4 below to form Recipes 2.1 to 2.20. Within 4 hours after the start of mixing, the fluidity defects such as solidification and semi-solidification were visually observed in Recipes 2.1 to 2.20 (color-fixing compositions). The inorganic toner (red) is iron oxide red, the inorganic toner (black) is iron oxide black, the inorganic toner (white) is titanium dioxide, the organic toner (blue) is phthalocyanine toner, the organic toner (purple) is triphenodioxazine toner, and the inorganic toner (yellow) is iron oxide yellow. [Table 4]

[0075] As can be seen from the results (not shown), after the above 20 types of color-fixing compositions (inks) were placed, it was found that the ink did not solidify when the ratio was 40% pearl toner and 4% organic toner, when the ratio was 20% pearl toner and 4% inorganic toner, when the ratio was 22% pearl toner and 12% organic and inorganic toner, and when the ratio was 32% pearl toner and 14% inorganic toner. However, when the ratio was 40% pearl toner and 1-4% inorganic toner, the color-fixing composition solidified, and the time for solidification after stirring and cooling was within approximately 4 hours, and the solidified ink could not be transferred to the lens.

[0076] This disclosure describes a method for stably adhering pearl toner to lenses using a color-fixing composition, forming a patterned layer to enhance wearing safety, and exhibiting a specific pattern and color through the color-fixing composition.

[0077] While the embodiments described above limit the Disclosure, those embodiments do not limit the Disclosure, and those skilled in the art can make various changes and modifications without departing from the spirit and scope of the Disclosure, and the scope of protection of the Disclosure shall be as defined by the claims attached thereto. [Explanation of Symbols]

[0078] 100: Method S102~S116: Process

Claims

1. Pearl pigments and Auxiliary agents, A color-fixing composition for contact lenses, comprising: The aforementioned auxiliary agent, Solvents containing alcohols, amines, ketones, alkenes, esters, or combinations thereof, A thickening agent comprising polyacrylic acid resin, polymethacrylic acid resin, polystyrene resin and its derivatives, polyamide, or a combination thereof, A hydrophilic polymer comprising polyvinyl alcohol, cellulose and its derivatives, polyethylene glycol, polyvinylpyrrolidone and its copolymers, or combinations thereof, A dispersant comprising polycarboxylic acids, ammonium salts, or combinations thereof, Includes, The color-fixing composition wherein, with the total weight of the color-fixing composition being 100%, the weight percentage of the pearl pigment is 5% to 40%, and the weight percentage of the auxiliary agent is 60% to 95%.

2. The color-fixing composition according to claim 1, wherein the ammonium salts include alkyltrimethylbenzylammonium salt, dialkyldimethylammonium salt, or alkylammonium salt.

3. The color-fixing composition according to claim 1, wherein the pearl pigment contains mica, aluminum calcium borosilicate, alumina, or silicon dioxide as a matrix, and the surface of the matrix is ​​coated with titanium dioxide, iron oxide, tin oxide, or a combination thereof.

4. The color-fixing composition according to claim 1, further comprising an inorganic pigment, an organic pigment, or a combination thereof.

5. The color-fixing composition according to claim 4, wherein the inorganic pigment comprises titanium dioxide pigments, titanium phenol pigments, iron oxide pigments, or a combination thereof.

6. If the total weight of the aforementioned color-fixing composition is 100%, The weight percentage of the aforementioned pearl pigment is 15% to 20%. The weight percentage of the inorganic pigment is 1% to 20%. The color-fixing composition according to claim 4, wherein the weight percentage of the auxiliary agent is 60% to 84%.

7. The color-fixing composition according to claim 4, wherein the organic pigment comprises a bisazo pigment, a monoazo pigment, a phthalocyanine pigment, a triphenodioxazine pigment, or a combination thereof.

8. If the total weight of the aforementioned color-fixing composition is 100%, The weight percentage of the aforementioned pearl pigment is 15% to 35%. The weight percentage of the aforementioned organic pigment is 1% to 4%. The color-fixing composition according to claim 4, wherein the weight percentage of the auxiliary agent is 60% to 84%.

9. If the total weight of the aforementioned color-fixing composition is 100%, The weight percentage of the aforementioned pearl pigment is 10% to 30%. The weight percentage of the inorganic pigment is 1% to 25%. The weight percentage of the aforementioned organic pigment is 1% to 4%. The color-fixing composition according to claim 4, wherein the weight percentage of the auxiliary agent is 60% to 85%.

10. A step of providing the color-fixing composition according to claim 1, A step of filling a template with a color-fixing composition to form a colloidal layer, The process involves transferring the colloidal layer into a first mold and forming a pattern layer after curing. A step of injecting the composition into the first mold and covering the pattern layer, A step of curing the pattern layer and the composition to form a lens with a pearlescent tint, A method for manufacturing lenses with a pearlescent tint, including [a specific component].

11. The manufacturing method according to claim 10, wherein the composition comprises a hydrogel or a silicone hydrogel.

12. The manufacturing method according to claim 10, further comprising the step of clamping the second mold and the first mold after the step of injecting the composition into the first mold and covering the pattern layer.

13. The manufacturing method according to claim 10, wherein the position of the pattern layer corresponds to the iris, sclera, or a combination thereof of the eye.

14. The manufacturing method according to claim 10, wherein the pattern layer has a random pattern.

15. The manufacturing method according to claim 10, wherein the pattern layer has a non-random pattern.

16. The manufacturing method according to claim 10, wherein the step of curing the pattern layer and the composition includes a step of curing the pattern layer and the composition with ultraviolet light or heat.

17. The lens body and A pattern layer formed by curing the color-fixing composition described in claim 1, which is coated on the lens body, Contact lenses containing a pearlescent color-fixing composition.

18. The contact lens according to claim 17, wherein the position of the pattern layer corresponds to the iris, sclera, or a combination thereof of the eye.

Images