Cosmetic composition containing vitamin B3 compound and lauroyl lysine

Abstract

The present invention is directed to a cosmetic composition comprising, by weight, about 1% to about 15% of a vitamin B3 compound, about 0.1% to about 10% of lauroyl lysine, and about 55% to about 98% of water, which satisfies at least one of the following conditions (i) to (iii): (i) the weight ratio of the vitamin B3 compound to the lauroyl lysine is about 15:1 to about 1:10, (ii) the lauroyl lysine has an average particle size of about 10 microns to about 40 microns, and (iii) the lauroyl lysine has a flat polygonal shape. The composition of the present invention provides the effects attributable to the vitamin B3 compound, which realizes reduced friction, reduced resistance, and / or improved smoothness.

Description

Technical Field

[0001] The present invention relates to a cosmetic composition comprising, by weight, about 1% to about 15% of a vitamin B3 compound, about 0.1% to about 10% of lauroyl lysine, and about 55% to about 98% of water, wherein the composition satisfies at least one of the following conditions (i) to (iii): (i) the weight ratio of the vitamin B3 compound to lauroyl lysine is about 15:1 to about 1:10; (ii) lauroyl lysine has an average particle size of about 10 microns to about 40 microns; and (iii) lauroyl lysine has a flat polygonal shape. The composition of the present invention provides an effect resulting from the vitamin B3 compound that realizes a reduction in the feeling of friction, a reduction in the feeling of resistance, and / or an improvement in the smooth feeling.

Background Art

[0002] Mammalian keratinous tissues, particularly human skin, are subject to various damages caused by both exogenous and endogenous factors. Such exogenous factors include ultraviolet rays, environmental pollution, wind, heat, infrared rays, low humidity, strong surfactants, abrasives, and the like. On the other hand, endogenous factors include aging over time and other biochemical changes within the skin. Whether exogenous or endogenous, these factors result in visible signs of skin damage. Typical skin damages in aged or damaged skin include fine wrinkles, wrinkles, hyperpigmentation, poor complexion, sagging, dark circles under the eyes, swollen eyes, enlarged pores, a decrease in turnover rate, and abnormal scaling or peeling. Additional damages resulting from both exogenous and endogenous factors include visible necrotic skin, i.e., peeling, flaking, dryness, and roughness.

[0003] Currently, there are several personal care products available to consumers that aim to improve the health and physical appearance of keratinous tissues such as skin, hair, and nails. The majority of these products aim to delay, minimize, or even eliminate wrinkles, age spots, and other histological changes typically associated with skin aging or environmental damage to human skin. Consumers prefer topical products because they are not only effective but also safe and pleasant to use.

[0004] Some cosmetics contain vitamin B3 compounds, such as niacinamide, to regulate various skin conditions.

[0005] However, the inventors have found that, in particular, when vitamin B3 compounds are included in cosmetic compositions containing higher levels of water, when vitamin B3 compounds are included in cosmetic compositions containing lower levels of humectants, particularly glycerin, when vitamin B3 compounds are included in cosmetic compositions containing lower levels of oil, and / or when vitamin B3 compounds are included in higher levels in such cosmetic compositions, vitamin B3 compounds such as niacinamide may cause increased friction, increased resistance, and / or a decrease in smoothness during and after application to the skin. Although not limited to theory, it is believed that such increased friction, increased resistance, and / or a decrease in smoothness is due to the re-solidification of vitamin B3 compounds such as niacinamide on the skin surface during and after application to the skin. [Overview of the Initiative] [Problems that the invention aims to solve]

[0006] Based on the above, there is a need for cosmetic compositions that produce effects attributable to vitamin B3 compounds, resulting in reduced friction, reduced resistance and / or improved smoothness, particularly when vitamin B3 compounds are included in cosmetic compositions containing a higher level of water; when vitamin B3 compounds are included in cosmetic compositions containing a lower level of humectants, particularly glycerin; when vitamin B3 compounds are included in cosmetic compositions containing a lower level of oil; and / or when vitamin B3 compounds are included in such cosmetic compositions at a higher level.

[0007] Furthermore, the following: This composition, containing a higher level of water, provides a refreshing / light feel while simultaneously reducing friction, resistance, and / or improving smoothness, all due to the effects of the vitamin B3 compound; This composition, containing lower levels of wetting agents, particularly glycerin, provides a refreshing / light feel while simultaneously achieving reduced friction, reduced resistance, and / or improved smoothness due to the effects of vitamin B3 compounds; The effects of the vitamin B3 compound that reduce the greasy shine / oily gloss caused by this composition, while simultaneously reducing friction, resistance, and / or improving smoothness; and Reduced friction, reduced resistance, and / or improved smoothness due to the effects of high levels of vitamin B3 compounds. A cosmetic composition that achieves at least one of these may be required. [Means for solving the problem]

[0008] This invention is based on weight, Approximately 1% to 15% of vitamin B3 compounds, Approximately 0.1% to approximately 10% lauroyl lysine, Approximately 55% to 98% water, A cosmetic composition comprising, The composition meets the following conditions (i) to (iii): (i) The weight ratio of vitamin B3 compound to lauroyl lysine is approximately 15:1 to approximately 1:10. (ii) Lauroyl lysine has an average particle size of about 10 microns to about 40 microns, and (iii) Lauroyl lysine has a flattened polygonal shape, The subject is a cosmetic composition that satisfies at least one of the following conditions.

[0009] It has now been discovered that, under certain conditions, the cosmetic compositions of the present invention, by using lauroyl lysine together with a vitamin B3 compound, produce effects attributable to the vitamin B3 compound, resulting in reduced friction, reduced resistance, and / or improved smoothness, whether the vitamin B3 compound is included in a cosmetic composition containing a higher level of water, a lower level of humectant, particularly glycerin, a lower level of oil, or even when the vitamin B3 compound is included in a cosmetic composition containing a higher level of oil. [Brief explanation of the drawing]

[0010] [Figure 1] This graph illustrates the coefficient of friction of composition 2 (5% niacinamide) compared to composition 3 (5% niacinamide + 2% Amihope LL). [Figure 2] This graph illustrates the coefficient of friction of composition 4 (10% niacinamide) compared to composition 5 (10% niacinamide + 2% Amihope LL). [Modes for carrying out the invention]

[0011] References to “embodiments” and similar terms in this specification mean that certain materials, features, structures, and / or properties described in relation to that embodiment are included in at least one embodiment, and optionally many embodiments, but not that all embodiments incorporate the described materials, features, structures, and / or properties. Furthermore, materials, features, structures, and / or properties may be combined in any preferred manner across different embodiments, and materials, features, structures, and / or properties may be excluded from or substituted for those described. Accordingly, the embodiments and aspects described herein may include or be combined with elements or components of other embodiments and / or aspects, even if they are not explicitly illustrated in combination, unless otherwise specified or incompatible.

[0012] In all embodiments, unless otherwise stated, all percentages of ingredients are based on the weight of the cosmetic composition. Unless otherwise specified, all ratios are weight ratios. Significant figures do not represent limitations on the quantities indicated or on the precision of the measurements. Unless otherwise specified, all quantities are understood to be modified by the word “approximately”. Unless otherwise specified, all measurements are understood to have been made under ambient conditions of approximately 25°C, where “ambient conditions” means conditions of approximately 1 atmosphere and approximately 50% relative humidity. All numerical ranges are inclusive and can be combined to form narrower ranges not expressly disclosed. For example, separated upper and lower range limits are interchangeable in creating further ranges.

[0013] The compositions of the present invention include, consist of, or comprise essential and optional components as described herein. As used herein, “consistently comprised of” means that a composition or component may contain only additional components that do not substantially alter the basic and novel properties of the claimed composition or method. As used herein and in the appended claims, the singular forms “a,” “an,” and “the” are intended to include the plural form unless the context clearly indicates otherwise.

[0014] definition "Approximately" modifies a specific value by referring to a range equal to plus or minus 20 percent (±20%) of the mentioned value, or a value lower than that (for example, 15%, less than 10%, or even less than 5%).

[0015] When used in relation to the composition, "apply" or "apply" means applying or spreading the composition of the present invention onto the surface of human skin, such as the epidermis.

[0016] In this specification, "derivative" means an amide, ether, ester, amino, carboxyl, acetyl, and / or alcohol derivative of a given compound.

[0017] "Effective amount" means an amount of compound or composition sufficient to significantly induce a positive effect on keratinous tissue over the course of the treatment period. The positive effect may be a health, appearance, and / or tactile effect, including, individually or in combination, the effects disclosed herein.

[0018] "Cosmetic agent" means any substance and any of its components intended to be rubbed, poured, sprinkled, sprayed, introduced, or otherwise applied to the body of a mammal or any part thereof for the purpose of providing a cosmetic effect. Examples of cosmetic agents include materials used in non-cosmetic consumer products such as substances generally recognized as safe (GRAS) by the US Food and Drug Administration, food additives, and over-the-counter drugs.

[0019] "Cosmetic composition" means a composition containing a cosmetic agent. Examples of cosmetic compositions include color cosmetics (e.g., foundation, lipstick, concealer, and mascara), skin care compositions (e.g., moisturizers and sunscreens), personal care compositions (e.g., rinse-off and non-rinse-off body soaps and bar soaps), and hair care compositions (e.g., shampoos and conditioners).

[0020] "Skin care" means adjusting and / or improving the skin condition (e.g., skin health, appearance, or texture / feel). Some non-limiting examples of improving the skin condition include improving the appearance and / or feel of the skin by providing a smoother and more uniform appearance and / or feel, increasing the thickness of one or more layers of the skin, improving the elasticity or resilience of the skin, improving the firmness of the skin, reducing the greasy, shiny, and / or dull appearance of the skin, improving the moisture content or hydration of the skin, improving the appearance of fine lines and / or wrinkles, improving skin exfoliation or flaking, plumping the skin, improving skin barrier properties, improving the skin color, reducing the appearance of redness or skin discoloration, and / or improving the brightness, gloss, or transparency of the skin.

[0021] "Skin care active substance" means a compound or combination of compounds that, when applied to the skin, has an acute effect and / or a chronic effect on a type of cell normally found in the skin or within the skin. A skin care active substance can regulate and / or improve the skin or cells associated with it (e.g., improve skin elasticity, skin moisture content, skin barrier function, and / or cell metabolism).

[0022] "Skin care composition" means a composition that contains a skin care active substance and regulates and / or improves the condition of the skin.

[0023] "Synergy" and its variations mean that the effect provided by the combination of two or more materials is greater than the additive effect expected for these materials.

[0024] As used herein, "treatment period" means the length and / or frequency of time that a material or composition is applied to the target skin surface.

[0025] Cosmetic composition The cosmetic composition of the present invention contains a vitamin B3 compound, lauroyl lysine, and water, and the composition satisfies at least one of the following conditions (i) to (iii): (i) The weight ratio of the vitamin B3 compound to lauroyl lysine is from about 15:1 to about 1:10, preferably from about 10:1 to about 1:10, more preferably from about 8:1 to about 1:5. (ii) Lauroyl lysine has an average particle size of from about 10 microns to about 40 microns, preferably from about 15 microns to about 35 microns, more preferably from about 20 microns to about 30 microns, and (iii) Lauroyl lysine has a flat polygonal shape. satisfies at least one of them.

[0026] This composition, especially when the composition has a higher level of water, preferably has a viscosity of from about 100 cP to about 20,000 cP, more preferably from about 1000 cP to about 15,000 cP.

[0027] If the composition of the present invention contains cetyl alcohol, stearyl alcohol, and / or behenyl alcohol, it is preferable that the composition contains limited amounts of such cetyl alcohol, stearyl alcohol, and behenyl alcohol to provide a refreshing / light feel compared to compositions containing a higher level of water. The total level of cetyl alcohol, stearyl alcohol, and behenyl alcohol in the composition is preferably at most about 0.5%, more preferably at most about 0.3%, even more preferably at most about 0.1%, and even more preferably 0%.

[0028] If the composition of the present invention contains a liquid oil having a higher refractive index (at ambient temperature), it is preferable that the composition contains a limited amount of such liquid oil, i.e., a liquid oil having a refractive index greater than 1.455, in order to reduce the greasy shine / oily gloss caused by the oil derived from the composition. The total level of such liquid oil in the composition is preferably at most about 3%, more preferably at most about 1%, and even more preferably at most about 0.5%.

[0029] If the composition of the present invention contains liquid oil (at ambient temperature), the total level of such liquid oil (at ambient temperature) in the composition is preferably at most about 10%, more preferably 7% or less, regardless of refractive index. The cosmetic compositions of this specification are intended for topical application to human skin. The compositions of this specification may optionally contain one or more additional dermatoactive substances or other components of the type commonly found in topical cosmetic compositions.

[0030] The cosmetic compositions described herein may be cosmetic compositions, pharmaceutical compositions, or medicated cosmetic compositions, and may be provided in a variety of product forms, including but not limited to solutions, suspensions, lotions, gels, toners, cleansing solutions, hydrogels, and film-forming products. In some cases, the form of the composition may depend on a specific dermatologically acceptable carrier selected. For example, the composition (and carrier) may be provided in the form of an emulsion (e.g., water-in-oil, oil-in-water, or water-in-oil-in-water) or an aqueous dispersion. Preferably, the cosmetic compositions of the present invention are in the form of an oil-in-water emulsion.

[0031] Vitamin B3 compounds This composition contains a safe and effective amount of vitamin B3 compound for modulating various skin conditions, as described, for example, in U.S. Patent No. 5,939,082. The composition in this invention contains about 1% to about 15%, preferably about 1.5% to about 15%, more preferably about 2% to about 15%, and even more preferably about 3.5% to about 15% of vitamin B3 compound.

[0032] In this specification, "vitamin B3 compound" means a compound having the following formula:

[0033] [ka] (In the formula, R is CONH2 (i.e., niacinamide), COOH (i.e., nicotinic acid), or CH2OH (i.e., nicotinyl alcohol); its derivatives, and salts of any of the above. Exemplary derivatives of vitamin B3 compounds include nicotinic acid esters, including non-vasodilatory esters of nicotinic acid (e.g., tocopheryl nicotinate, myristyl nicotinate), nicotinamide riboside, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide, and niacinamide N-oxide. In some cases, vitamin B3 compounds such as niacinamide may have improved efficacy at relatively low pH, for example, as described in U.S. Patent Application Publication No. 2020 / 0009123. Preferably, niacinamide is used as the vitamin B3 compound in the present invention.

[0034] In some cases, it may be desirable that the cyclic nitrogen of the vitamin B3 compound is “not complexed” (e.g., chemically unbonded and / or non-hindered) in the composition and / or before application to the target skin surface. For example, the compositions herein may contain or substantially no salts or complexes of the vitamin B3 compound (i.e., less than 3%, 2%, 1%, or even less than 0.5%). Typical methods for minimizing or preventing the formation of undesirable salts and / or complexes include the removal of substances that form substantially irreversible or other undesirable complexes with the vitamin B3 compound in the composition, pH adjustment, ionic strength adjustment, use of surfactants, and the implementation of a formulation process in which the vitamin B3 compound and the substances that form complexes with it are in different phases.

[0035] Humectant The composition of the present invention preferably contains a wetting agent at a level of about 0.5% to about 20% by weight, preferably about 1% to about 15% by weight, more preferably about 2% to about 15% by weight, and even more preferably about 4% to about 12% by weight of the composition.

[0036] In the present invention, when glycerin is included in the composition as a wetting agent, it is preferable that the glycerin is included at a level in which the weight ratio of glycerin to the vitamin B3 compound is in the range of up to about 1.5:1, more preferably up to about 1.2:1, even more preferably up to about 1:1, and even more preferably up to about 0.8:1. It is also preferable that the glycerin is included at a level in which the weight ratio of glycerin to the vitamin B3 compound is in the range starting from about 1:20.

[0037] Useful humectants in this specification are polyhydric alcohols intended to moisturize, reduce exfoliation, and stimulate the removal of accumulated exfoliation from the skin. Useful polyhydric alcohols in this specification include, for example, alkylene polyols and their derivatives, and polyalkylene glycols. Useful polyhydric alcohols in this specification include, for example, propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, pentylene glycol, 1,3-butylene glycol, 1,2,6-hexanetriol, glycerin, ethoxylated glycerin, propoxylated glycerin, and mixtures thereof. Preferred humectants in this specification are glycerin, pentylene glycol, 1,3-butylene glycol, and propylene glycol. Most preferably, and especially when using higher levels of vitamin B3 compounds that may cause resistance during application and / or reduced moisture after application, the humectant is glycerin.

[0038] Lauroyl lysine The composition of the present invention contains lauroyllysine at a level of about 0.1% to about 10%, preferably about 0.3% to about 7%, and more preferably about 0.5% to about 5%.

[0039] The shape of lauroyllysine may be anything. Preferably, the shape of lauroyllysine is spherical or a flattened polygon (selected from a flattened pentagon, a flattened hexagon, and a flattened heptagon, preferably a flattened hexagon).

[0040] For flattened, polygonal-shaped lauroyl lysine particles, an average particle size of approximately 10 to 40 microns, more preferably 15 to 35 microns, and more preferably 20 to 30 microns, is preferable, considering the improvement of sensory feel. This is because particles that are too small may not provide a sufficiently elastic / soft feel, and particles that are too large may result in a scrubbing-like feel.

[0041] A commercially available example of such a flattened, polygonal lauroyl lysine with this particle size is Amihope LL, available from Ajinomoto Co., Inc., which has a flattened hexagonal shape and an average particle size of 20-30 microns.

[0042] The spherical lauroyl lysine particles preferably have an average particle size of about 1 micron to about 30 microns, more preferably about 2 microns to about 20 microns, and more preferably about 3 microns to 8 microns.

[0043] Compared to starch solid powder and cellulose solid powder, lauroyl lysine is thought to provide improved moisture / elasticity and address the potential need to improve dryness and / or powderiness during or after application of compositions to the skin, which may be caused by vitamin B3 compounds such as niacinamide due to the re-solidification of vitamin B3 compounds on the skin surface.

[0044] Similarly, lauroyl lysine is thought to reduce pilling and / or aggregation compared to hydrophilic solid polymer powders such as starch solid powder and cellulose solid powder, especially when the composition contains a high level of hydrophilic thickener. Due to such reduction in pilling and / or aggregation, it is preferable that the composition is substantially free of such hydrophilic solid powders, i.e., contains only 0.1% or less, more preferably 0.05% or less, of such hydrophilic solid powders. Even more preferably, the composition of the present invention is free of such hydrophilic solid powders, i.e., contains 0% of such hydrophilic solid powders.

[0045] Lauroyl lysine may also cause a matte appearance and / or reduced visibility of skin pores.

[0046] Aqueous carrier / water The composition preferably comprises an aqueous carrier. Preferably, the aqueous carrier is substantially water. Preferably, deionized water is used. Depending on the desired properties of the composition, water derived from natural sources containing mineral cations may also be used.

[0047] The composition of the present invention contains water at a level of about 55% to about 98% by weight, preferably about 60% to about 98% by weight, more preferably about 60% to about 95% by weight, and even more preferably about 60% to about 90% by weight.

[0048] In some cases, the compositions herein are in the form of oil-in-water ("O / W") emulsions that provide a light, non-greasy feel. Preferred O / W emulsions herein may contain more than 50% by weight of a continuous aqueous phase, with the remainder being a dispersed oil phase. The aqueous phase may contain 1% to 99% water, based on the weight of the aqueous phase, along with any water-soluble and / or water-miscible components. In these cases, the dispersed oil phase is typically present in less than 30% by weight of the composition (e.g., 1% to 20% by weight, 2% to 15% by weight, 3% to 12% by weight, 4% to 10% by weight, or even 5% to 8% by weight) to help avoid some of the undesirable tactile effects of the oily composition. The oil phase may contain one or more volatile oils and / or non-volatile oils (e.g., vegetable oils, silicone oils, and / or hydrocarbon oils).

[0049] pH of the composition Typically, cosmetic compositions are formulated to have a slightly acidic to neutral pH (i.e., 5.0–7.0) which is thought to improve the stability of certain components in the composition (e.g., niacinamide, salicylates, and neutralized thickeners). However, formulating skincare compositions at a low pH (e.g., 2.0–5.0) can also achieve certain effects such as improving the appearance of the skin, strengthening the skin's acidic mantle, exfoliating the skin, improving skin texture, and / or providing greater flexibility in product formulation.

[0050] The compositions of the present invention may have an even lower pH, i.e., less than 5.0, preferably about 1.5 to about 4.9, more preferably about 2.0 to about 4.5, even more preferably about 2.5 to about 4.0, or even more preferably about 3.5 to about 4.0.

[0051] Virtually no microplastic solid particles The compositions of the present invention containing lauroyl lysine can achieve effects attributable to vitamin B3 compounds, reducing friction, reducing resistance, and / or improving smoothness, without using microplastic solid particles. Therefore, the compositions of the present invention can also achieve environmental benefits, considering the reduction in the use of microplastic solid particles. Such microplastic solid particles are, for example, nylon powder, polyurethane powder, polyethylene powder, and silicone resin powder. In the present invention, it is preferable that the compositions are substantially free of such microplastic solid particles. More preferably, the compositions of the present invention are free of such microplastic solid particles, i.e., contain 0% such microplastic solid particles.

[0052] Skin conditioning agent Optionally, the composition of the present invention may further contain a skin conditioning agent. These agents may be selected from humectants and emollients. The amount of the skin conditioning agent may be in the range of about 1% to about 50% by weight of the composition, preferably about 2% to about 40% by weight, and more preferably about 5% to about 30% by weight.

[0053] The humectant is a polyhydric alcohol intended to moisturize, reduce exfoliation, and stimulate the removal of accumulated exfoliation from the skin. Typical polyhydric alcohols include polyalkylene glycols, more preferably alkylene polyols, and their derivatives. Examples include propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, 1,2,6-hexanetriol, ethoxylated glycerin, propoxylated glycerin, and mixtures thereof. Most preferably, the humectant is glycerin.

[0054] If the conditioning agent is a skin emollient, it may be selected from hydrocarbons, fatty acids, aliphatic alcohols, and esters.

[0055] Faliphatic alcohols The compositions described herein may contain aliphatic alcohols. Aliphatic alcohols are high molecular weight linear primary alcohols having the following general structure:

[0056] [ka] It refers to, In the formula, n = 8 to 32.

[0057] Aliphatic alcohols may be natural or synthetic, saturated or unsaturated, branched or linear. Some non-limiting examples of aliphatic alcohols commonly used in cosmetic compositions include caprin alcohol, caprylic alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, and behenyl alcohol. Aliphatic alcohols as used herein may be referred to collectively by the number of carbon atoms in the molecule. For example, "C12 alcohol" refers to an alcohol having 12 carbon atoms in its chain (i.e., dodecanol).

[0058] Aliphatic alcohols may be included in the Composition as specified in an amount of 0.0001% to 15% by weight (for example, 0.0002% to 10% by weight, 0.001% to 15% by weight, 0.025% to 10% by weight, 0.05% to 7% by weight, 0.05% to 5% by weight, or further 0.1% to 3% by weight).

[0059] Whitening agent The compositions of the present invention may contain whitening agents. In this specification, useful whitening agents refer to active ingredients that not only alter the appearance of the skin but also further improve excessive hyperpigmentation compared to before treatment. Useful whitening agents in this specification include ascorbic acid compounds, vitamin B3 compounds, azelaic acid, butylhydroxyanisole, gallic acid and its derivatives, hydroquinone, kojic acid, arbutin, mulberry extract, tetrahydrocurcumin, and mixtures thereof. The combined use of whitening agents is considered advantageous because they may produce whitening effects through different mechanisms.

[0060] When used, this composition preferably contains a whitening agent in an amount of about 0.1% to about 10% by weight, more preferably about 0.2% to about 5% by weight.

[0061] Ascorbic acid compounds are useful whitening agents, and ascorbyl glucoside is a preferred derivative of ascorbic acid compounds.

[0062] Conditioning agent The compositions described herein may contain 0.1% to 50% by weight of a conditioning agent (e.g., 0.5% to 30% by weight, 1% to 20% by weight, or even 2% to 15% by weight). The addition of a conditioning agent can help provide a composition having desirable tactile properties (e.g., a silky smooth feel upon application). Some non-limiting examples of conditioning agents include hydrocarbon oils and waxes, silicones, fatty acid derivatives, cholesterol, cholesterol derivatives, diglycerides, triglycerides, vegetable oils, vegetable oil derivatives, acetoglyceride esters, alkyl esters, alkenyl esters, lanolin, wax esters, beeswax derivatives, sterols and phospholipids, salts, isomers, and derivatives thereof, as well as combinations thereof.

[0063] Particularly preferred examples of conditioning agents include volatile silicone fluids such as dimethicone copolyol, dimethylpolysiloxane, diethylpolysiloxane, mixed C1-30 alkylpolysiloxane, phenyldimethicone, dimethiconol, dimethicone, dimethiconol, silicone crosspolymers, and combinations thereof. Dimethicone may be particularly preferred because some consumers associate the tactile properties provided by certain dimethicone fluids with good moisturizing properties.

[0064] Hydrophilic thickener In some embodiments, the composition of the present invention may further contain one or more hydrophilic thickeners. If present, the composition preferably contains about 0.01% to about 5% by weight, more preferably about 0.1% to about 4% by weight, and even more preferably about 0.1% to about 3% by weight of the hydrophilic thickener.

[0065] The hydrophilic thickeners useful in this specification are not particularly limited, as long as they are commonly used in cosmetics. Examples include natural or semi-synthetic water-soluble polymers, synthetic water-soluble polymers, and inorganic water-soluble polymers.

[0066] As natural or semi-synthetic water-soluble polymers, polysaccharides and their derivatives (including water-soluble alkyl-substituted polysaccharide derivatives) are preferably used. Specifically, examples include plant-based polymers such as gum arabic, tragacanth gum, galaetan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), algal gel (brown algae extract), starch (rice, corn, potato, wheat), and glycyrrhizic acid; microbial-based polymers such as xanthan gum, dextran, succinoglycan, and pullulan; starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch; cellulose-based polymers such as methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, sodium carboxymethylcellulose (CMC), crystalline cellulose, and cellulose powder; and alginic acid-based polymers such as sodium alginate and propylene glycol ester of alginic acid.

[0067] Examples of synthetic water-soluble polymers include ionic or nonionic water-soluble polymers, such as vinyl-based polymers like polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, and carboxyvinyl polymer (carbomer); and acrylic-based polymers such as sodium polyacrylate, ethyl polyacrylate, polyacrylamide compounds, and acrylic acid / alkyl methacrylate copolymer (trade name "pemulen TR-1").

[0068] Examples of polyacrylamide compounds include polyacrylamide compounds comprising a homopolymer, copolymer, or crosspolymer containing one or more structural units selected from 2-acrylamide-2-methylpropanesulfonic acid (hereafter referred to as "AMPS"), acrylic acid, and derivatives thereof.

[0069] Specific examples of such polyacrylamide compounds include vinylpyrrolidone / 2-acrylamide-2-methylpropanesulfonic acid (salt) copolymer, dimethylacrylarnide / 2-acrylamide-2-methylpropanesulfonic acid (salt) copolymer, acrylamide / 2-acrylamiclo-2-methylpropanesulfonic acid copolymer, methylenebisacrylamide-crosslinked dimethylacrylainide / 2-acrylamide-2-methylpropanesulfonic acid crosspolymer, mixtures of polyacrylamide and sodium polyacrylate, sodium acrylate / 2-acrylamide-2-methylpropanesulfonic acid copolymer, hydroxyethyl acrylate / 2-acrylamide-2-methylpropanesulfonic acid (salt) copolymer, ammonium polyacrylate, polyacrylamide / ammonium acrylate copolymer, and acrylamide / sodium acrylate copolymer. However, the compounds are not limited to these.

[0070] Preferred examples of salts in the previous paragraph include alkali metal salts (such as calcium and magnesium salts), ammonium salts, and organic amine salts (such as monoethanolamine salts, diethanolamine salts, and triethanolamine salts). One or more of these polyacrylamide compounds may be used.

[0071] These polyacrylamide compounds may be synthesized or available as commercial products. For example, vinylpyrrolidone / 2-acrylarnido-2-methylpropanesulfonic acid(salt) copolymer may be "Aristoflex AVC" (Clariant), sodium alylate / 2-acrylamide-2-methylpropanesulfonic acid(salt) copolymer may be "Simulgel EG" (Seppic) or "Simulgel EPG" (Seppic), acrylamide / 2-acrylamide-2-methylpropanesulfonic acid sodium salt copolymer may be "Simulgel 600" (Seppic), acrylamide / 2-acrylamide-2-methylpropanesulfonic acid(salt) may be "Sepigel 305" (Seppic) or "Sepigel 501" (Seppic), and the homopolymer of 2-acrylamide-2-methylpropanesulfonic acid sodium may be "1-lostacerin It may be "AMPS" (manufactured by Clariant) or "Simulgel 800" (manufactured by Seppic), and dimethylacrylamide / 2-acrylamide-2-methylpropanesulfonic acid may be "SU-Polymer 0-1" (manufactured by Toho Chemical Industry).

[0072] In the present invention, it is preferable to use the following: carboxypolymers (carbomers), for example, those traded as Carbopol940 and Carbopol980; and acrylate / alkyl (meth)acrylate copolymers, for example, those with the INCI name acrylate / C10-30 alkyl acrylate crosspolymer, for example, those traded as Carbopol1342 polymer, Carbopol Ultrez20, Carbopol Ultrez21, Pemulen TR-1 and Pemulen TR-2. By using lauroyl lysine together with these thickeners, the composition has a sufficient thickening effect from these thickeners, while at the same time reducing the viscosity and / or resistance caused by these thickeners, especially when such polymers are used at higher levels, such as 0.2% or more. These polymers may be included in the composition at a level of about 0.05% to about 3%, preferably about 0.1% to about 2.5%, and more preferably about 0.2% to about 2%.

[0073] Polyacrylate crosspolymer 6, commercially available as "Sepimax Zen" from Seppic, may also be used herein, particularly in low pH environments.

[0074] In the present invention, it is sometimes preferable to use a hydrophilic thickener together with a wetting agent. By using lauroyl lysine together with a hydrophilic thickener and a wetting agent, the composition, when used with a wetting agent, reduces the stickiness derived from these thickeners, while the thickening polymer provides even greater stickiness.

[0075] The hydrophilic thickener in the water-based cosmetic of the present invention may be a combination of one or more types.

[0076] emulsifier If the composition is in the form of an emulsion, it may contain an emulsifier. The emulsifier may be nonionic, anionic, cationic, or zwitterionic. Some non-limiting examples of emulsifiers are disclosed in U.S. Patent Nos. 3,755,560, 4,421,769, U.S. Patent Application Publication No. 2006 / 0275237, and McCutcheon's Detergents and Emulsifiers, North American Edition, pp. 317-324 (1986). Preferred examples of emulsifiers include nonionic stearic acid derivative emulsifiers such as polysorbate-20, glyceryl stearate, sorbitan stearate, PEG-100 stearate, steareth-2, steareth-21, glycereth-25 pyrrolidone carboxylic acid isostearate, and combinations thereof.

[0077] Other optional components. The compositions described herein may contain one or more optional components known to be used in topical cosmetic compositions, provided that the optional components do not alter the desired benefits of the composition to an unacceptable degree. In some cases, it may be desirable to select active materials that function through different biological pathways so that the cosmetic active materials do not interfere with each other. If the composition is in the form of an emulsion, additional components should not introduce instability (e.g., syneresis) into the emulsion. For example, it may be desirable to select optional components that do not form complexes with other components in the composition, particularly pH-sensitive components such as vitamin B3 compounds, salicylates, and peptides.

[0078] The additional components should be suitable for use in contact with human skin tissue without causing excessive toxicity, incompatibility, instability, or allergic reactions. Optional components, if present, may be included in the composition in amounts of about 0.001% to 50% by weight (e.g., 0.01% to 40%, 0.1% to 30%, 0.5% to 20%, or 1% to 10%). Some non-limiting examples of additional ingredients include vitamins, minerals, peptides and peptide derivatives, sugar amines, sunscreens, oil control agents, microparticles, flavonoid compounds, hair growth regulators, antioxidants and / or antioxidant precursors, preservatives, protease inhibitors, tyrosinase inhibitors, anti-inflammatory agents, moisturizers, exfoliants, skin whitening agents, sunscreens, sunless tanning agents, lubricants, anti-acne agents, anti-cellulite agents, chelating agents, anti-wrinkle active substances, anti-atrophy active substances, phytosterols and / or plant hormones, N-acyl amino acid compounds, antibacterial agents, and antifungal agents. Some particularly preferred examples of additional ingredients include vitamin B3 compounds (e.g., niacinamide), vitamin B5 compounds (e.g., d-panthenol), n-acyl amino acids (e.g., undecylenoyl phenylalanine), vitamin E compounds (e.g., tocopheryl acetate), palmitoyl dipeptides (e.g., palmitoyl-lysine-threonine), palmitoyl pentapeptides (e.g., palmitoyl-lysine-threonine-threonine-lysine-serine), vitamin A compounds (e.g., retinol and retinyl propionate), and one or more skincare active substances selected from the group consisting of these combinations.Other non-limiting examples of optional ingredients and / or skincare active substances that may be suitable for use herein are U.S. Patent Applications Publications 2002 / 0022040, 2003 / 0049212, 2004 / 0175347, 2006 / 0275237, 2007 / 0196344, 2008 / 0181956, 2008 / 0206373, 2010 / 0092408, 2008 / 0206373, 2010 / 0239510, and 2010 / 0189669. These are described in Patent Nos. 2010 / 0272667, 2011 / 0262025, 2011 / 0097286, 2012 / 0197016, 2012 / 0128683, 2012 / 0148515, 2012 / 0156146 and 2013 / 0022557 of the United States Patent Nos. 5,939,082, 5,872,112, 6,492,326, 6,696,049, 6,524,598, 5,972,359 and 6,174,533 of the United States Patents.

[0079] Sucrose esters may be used herein. Such sucrose esters may be blends of two or more sucrose esters, which are present in a ratio of any one sucrose ester to another of any one sucrose ester of 1:10 to 1:1 (e.g., 1:7, 1:5, 1:3, or 1:2). In some cases, the sucrose ester may be a blend of sucrose laurate and sucrose dilaurate, with sucrose laurate present in 50% to 80% by weight of the sucrose ester and sucrose dilaurate present in 20% to 45% by weight of the sucrose ester. Alternatively, the sucrose ester may be a blend of sucrose laurate, sucrose dilaurate, and sucrose trilaurate, with sucrose dilaurate present in 35% or more by weight of the sucrose ester. An example of a sucrose ester particularly suitable for use herein is sucrose dilaurate BC10034, available from BASF.

[0080] Method of using cosmetic compositions The method of use described herein includes identifying a target area of ​​skin in a person in need of treatment and applying the composition to the target area of ​​skin over a treatment period. The target area of ​​skin may be located on the surface of the skin of the face, such as the forehead, perimum of the mouth, chin, perimum of the eyes, nose, and / or cheeks, or on another part of the body (e.g., hands, arms, legs, back, chest). A person in need of treatment is one whose skin shows signs of oxidative stress, such as fine lines, wrinkles, hyperpigmentation, uneven skin tone, and / or other visible skin features typically associated with aging. In some cases, the target area of ​​skin may not show visible signs of skin aging, but if it is what would normally cause such problems as a result of human aging, the user (e.g., a relatively young user) may still wish to target such skin areas. Thus, the method may be used as a preventive measure to delay the onset of visible signs of skin aging.

[0081] The composition may be applied daily, at least once, twice, or more frequently, to the targeted area of ​​skin and, if desired, to the surrounding skin during the treatment period. If applied twice daily, the first and second applications should be spaced at least 1 to 12 hours apart. Typically, the composition is applied in the morning and / or at night before bedtime. The treatment period may last for at least one week (e.g., about two, four, eight, or even twelve weeks). In some cases, the treatment period may extend to several months (i.e., three to twelve months). In some cases, during a treatment period of at least two, four, eight, or twelve weeks, the composition may be applied at least once or even twice a day for most of the week (e.g., at least four, five, or six days a week).

[0082] The application of this composition can be carried out by topical application. With respect to the application of this composition, the terms “topical,” “localized,” or “spot-to-spot” mean that the composition is delivered to a target area (e.g., wrinkles or fine lines) while minimizing delivery to skin surfaces where treatment is not desired. The composition may be applied to an area of ​​skin and gently massaged in. The form of the composition or a dermatologically acceptable carrier should be selected to facilitate topical application. While certain embodiments herein are intended for topical application of the composition to an area, it will be understood that the compositions herein may be applied broadly to one or more skin surfaces. In certain embodiments, the compositions herein may be used as part of a multi-step cosmetic procedure, in which case the compositions of the present invention may be applied before and / or after one or more other compositions.

[0083] combination 1. Based on weight, Approximately 1% to 15% of vitamin B3 compounds, Approximately 0.1% to approximately 10% lauroyl lysine, Approximately 55% to 98% water, A cosmetic composition comprising, The composition meets the following conditions (i) to (iii): (i) The weight ratio of vitamin B3 compound to lauroyl lysine is approximately 15:1 to approximately 1:10. (ii) Lauroyl lysine has an average particle size of about 10 microns to about 40 microns, and (iii) Lauroyl lysine has a flattened polygonal shape, A cosmetic composition that satisfies at least one of the following conditions. 2. A composition having the characteristics described above, wherein the composition contains approximately 3.5% to approximately 15% of a vitamin B3 compound. 3. A composition having any of the above characteristics, wherein the composition contains about 0.3% to about 7%, preferably about 0.5% to about 5%, of lauroyl lysine. 4. A composition having any of the above characteristics, further comprising about 0.5% to about 20% of a wetting agent. 5. A composition having any of the above characteristics, further comprising cetyl alcohol, stearyl alcohol, and behenyl alcohol at a total level of up to about 0.5%. 6. Any of the above-described compositions, further comprising glycerin in a weight ratio of glycerin to vitamin B3 compound of up to about 1.5:1, preferably up to about 1.2:1, more preferably up to about 1:1, and even more preferably up to about 0.8:1. 7. A composition having any of the characteristics described above, further comprising about 0.2% to about 2% of a hydrophilic thickener selected from the group consisting of carboxyvinyl polymers; acrylic acid / alkyl (meth)acrylate copolymers; and mixtures thereof. 8. A composition having any of the above characteristics, wherein the weight ratio of the vitamin B3 compound to lauroyl lysine is about 10:1 to about 1:10, preferably about 8:1 to about 1:5. 9. A composition having any of the above characteristics, wherein the lauroyl lysine has an average particle size of about 15 microns to about 35 microns, preferably about 20 microns to about 30 microns. 10. Use of any of the above-mentioned compositions for reducing friction, reducing resistance, and / or improving smoothness. 11. Use of any of the aforementioned compositions to bring about a reduction in the use of microplastic solid particles as an environmental benefit. [Examples]

[0084] [Table 1]

[0085] Compositions 1, 3, 5, and 6 are examples of the present invention, and are suitably used as oil-in-water emulsion cosmetic compositions in the form of essences, lotions, serums, and / or gel creams. Compositions 2 and 4 are comparative examples of the present invention that do not contain lauroyl lysine. The examples of the present invention achieve reduced friction, reduced resistance, and / or improved smoothness compared to the comparative examples, as shown in the results below.

[0086] method: A Trinity Lab i-tester (TL201Tt) was used for friction measurement. A 120-micron thick sample was prepared on the surface of BioSkin (Ohken A4 5T#BSC) using a BYK drawdown bar and dried for 24 hours before measurement.

[0087] The friction of a dried product film on a bioskin plate was measured using a polyurethane probe with a fingerprint-mimicking pattern under a vertical load of 50g / 40mm travel distance (50mm / sec) and 60 counts (rotations) (data was collected in 1 millisecond). The measurement was repeated three times and the average value was calculated.

[0088] result: Figure 1 shows the coefficient of friction of composition 2 (5% niacinamide) versus composition 3 (5% niacinamide + 2% Amihope LL). As shown in Figure 1, the formulation of composition 3 (5% niacinamide + 2% Amihope LL) consistently showed a lower coefficient of friction (COF) than composition 2 (5% niacinamide) during friction measurements. This indicates that the formulation of composition 3 (including Amihope LL), while containing a higher level of niacinamide in the formulation, achieves reduced friction, reduced resistance, and / or improved smoothness during and after application of the product compared to composition 2.

[0089] Figure 2 shows the coefficient of friction of composition 4 (10% niacinamide) compared to composition 5 (10% niacinamide + 2% Amihope LL).

[0090] As shown in Figure 2, the formulation of Composition 5 (10% niacinamide + 2% Amihope LL) consistently showed a lower coefficient of friction (COF) than Composition 4 (10% niacinamide) during friction measurements. This indicates that the formulation of Composition 5 achieves reduced friction, reduced resistance, and / or improved smoothness compared to Composition 4 during and after application of the product, even while containing a higher level of niacinamide in the formulation.

[0091] The dimensions and values ​​disclosed herein should not be understood as strictly limited to the exact numerical values ​​listed. Instead, unless otherwise indicated, each such dimension is intended to mean both the listed value and the functionally equivalent range encompassing that value. For example, a dimension disclosed as "40 mm" is intended to mean "approximately 40 mm."

[0092] All documents referenced herein, including any patents or patent applications that are cross-referenced or related, and any patent applications or patents to which this application claims priority or benefit thereof, are incorporated herein by reference in their entirety unless otherwise explicitly stated to be excluded or limited. No document reference shall be deemed prior art to any invention disclosed or claimed herein, nor shall it be deemed to teach, suggest or disclose any such invention, either alone or in combination with any other reference(s). Furthermore, if any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in any document incorporated by reference, the meaning or definition given to the term in this document shall prevail.

[0093] While specific embodiments of the present invention have been illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Therefore, it is intended that all such changes and modifications within the scope of the invention be covered in the appended claims.

Claims

1. Based on weight, 3.5% to 15% Vitamin B 3 Compounds and, 1.5% to 10% lauroyl lysine, 55% to 90% water, A cosmetic composition comprising, The aforementioned Vitamin B 3 The weight ratio of the compound to lauroyllysine is 5:1 to 1:

5. The lauroyl lysine has an average particle size of 10 microns (μm) to 40 microns (μm). The composition is an oil-in-water emulsion, and the dispersed oil phase is present in an amount of 1% to 8% by weight of the composition. The composition contains 4% to 12% glycerin, and the glycerin and the vitamin B 3 A cosmetic composition in which the weight ratio of the compound is a maximum of 1.5:

1.

2. The composition according to claim 1, wherein the composition comprises 1.5% to 7% lauroyl lysine.

3. The composition according to claim 2, wherein the composition comprises 1.5% to 5% lauroyl lysine.

4. The composition according to claim 1, wherein the composition further comprises 0.5% to 20% of a wetting agent.

5. The composition according to claim 1, further comprising cetyl alcohol, stearyl alcohol, and behenyl alcohol at a total level of up to 0.5%.

6. Glycerin and Vitamin B 3 The composition according to claim 1, wherein the weight ratio with respect to the compound is at most 1.2:

1.

7. Glycerin and Vitamin B 3 The composition according to claim 6, wherein the weight ratio with the compound is at most 1:

1.

8. Glycerin and Vitamin B 3 The composition according to claim 7, wherein the weight ratio with respect to the compound is a maximum of 0.8:

1.

9. The composition according to claim 1, further comprising 0.2% to 2% of a hydrophilic thickener selected from the group consisting of carboxyvinyl polymers, acrylic acid / alkyl (meth)acrylate copolymers, and mixtures thereof.

10. The composition according to claim 1, wherein the lauroyl lysine has an average particle size of 15 microns (μm) to 35 microns (μm).

11. The composition according to claim 10, wherein the lauroyl lysine has an average particle size of 20 microns (μm) to 30 microns (μm).

12. Use of the composition according to any one of claims 1 to 11 for reducing friction, reducing resistance, and / or improving smoothness.

13. Use of the composition according to any one of claims 1 to 11 to bring about a reduction in the use of microplastic solid particles as an environmental benefit.

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