Sample analysis device
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2025-01-27
- Publication Date
- 2026-08-13
AI Technical Summary
【0020】 本願では、第1回動中心と第2回動中心とを接続して前述の中心線を形成し、試薬容器一時保存機構と反応ディスクをそれぞれ前記中心線の両側に設け、且つ前記試薬容器転送機構を前記第1試薬容器格納機構と前記試薬容器一時保存機構との間、及び/又は、前記第2試薬容器格納機構と前記試薬容器一時保存機構との間で試薬容器を転送するように配置することにより、限られた空間の中で前記試薬容器一時保存機構、前記反応ディスク、前記第1試薬容器格納機構及び前記第2試薬容器格納機構などの複数の機構を設置するとともに、限られた空間内で2つの試薬容器格納機構による試薬容器の無停止なローディングを両立できるようにしている。
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Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of analytical instruments, and particularly to a specimen analyzer.
Background Art
[0002] Biochemical analyzers, immunoassays, and cell analyzers all belong to specimen analyzers and are instruments for performing qualitative and quantitative analysis on specimens.
[0003] In the process of continuously inspecting and analyzing specimens, if manual addition of reagents is performed in a specimen analyzer, it will not only affect the inspection efficiency of the analyzer, but the operator also has to wait for the analyzer to enter a state where reagents can be manually added. Therefore, ensuring the effective supply of reagents by loading reagents in real time without stopping based on the available reagent amount remaining in the reagent container storage mechanism is an urgent problem that must be solved when the specimen analyzer efficiently inspects specimens.
Summary of the Invention
Problems to be Solved by the Invention
[0004] The main object of the present application is to provide a specimen analyzer that can install two reagent container storage mechanisms within a limited space and can simultaneously achieve continuous loading of reagent containers without stopping for both of the two reagent container storage mechanisms.
Means for Solving the Problems
[0005] The specimen analyzer according to an aspect of the present invention a reaction disk provided on a stage, a first reagent container storage mechanism, a second reagent container storage mechanism, a reagent container temporary storage mechanism that places a reagent container and is located between the first reagent container storage mechanism and the second reagent container storage mechanism, and a reagent container transfer mechanism, The first rotational center of the first reagent container storage mechanism and the second rotational center of the second reagent container storage mechanism are connected to form a center line. The third rotational center of the reagent container temporary storage mechanism and the fourth rotational center of the reaction disk are located on either side of the center line, The reagent container transfer mechanism is used to transfer reagent containers between the first reagent container storage mechanism and the reagent container temporary storage mechanism, and / or between the second reagent container storage mechanism and the reagent container temporary storage mechanism.
[0006] Furthermore, the transfer path of the reagent container transfer mechanism is parallel to the center line, and the number of the first insertion / removal position of the first reagent container storage mechanism, the second insertion / removal position of the second reagent container storage mechanism, and the third insertion / removal position of the reagent container storage mechanism is at least one each.
[0007] Furthermore, the first reagent container storage mechanism includes a first storage inner plate and a first storage outer plate, the first storage inner plate being located inside the first storage outer plate, The first storage inner panel has a first inner insertion / removal position corresponding to the transfer path, and the first storage outer panel has a first outer insertion / removal position corresponding to the transfer path. The second reagent container storage mechanism includes a second storage inner plate and a second storage outer plate, the second storage inner plate being located inside the second storage outer plate, the second storage inner plate having a second inner insertion / removal position corresponding to the transfer path, and the second storage outer plate having a second outer insertion / removal position corresponding to the transfer path. The reagent container temporary storage mechanism includes a temporary storage inner plate and a temporary storage outer plate, the temporary storage inner plate being located inside the temporary storage outer plate, the temporary storage inner plate having a third inner insertion / removal position corresponding to the transfer path, and the temporary storage outer plate having a third outer insertion / removal position corresponding to the transfer path. The reagent container transfer mechanism is used to transfer a reagent container between the first inner loading / unloading position or the first outer loading / unloading position and the third inner loading / unloading position or the third outer loading / unloading position, and / or to transfer a reagent container between the second inner loading / unloading position or the second outer loading / unloading position and the third inner loading / unloading position or the third outer loading / unloading position.
[0008] Furthermore, the connection between the first inner insertion / retraction position and the first pivot center, and the connection between the first outer insertion / retraction position and the first pivot center, form a first angle. The connection between the second inner insertion / retraction position and the second pivot center, and the connection between the second outer insertion / retraction position and the second pivot center, form a second angle. The connection between the third inner insertion / retraction position and the third pivot center, and the connection between the third outer insertion / retraction position and the third pivot center, form a third angle.
[0009] Furthermore, the first storage inner plate is configured to form a plurality of first internal mounting positions for supporting reagent containers along the circumferential direction of the first pivot center, and the first storage inner plate rotates so that the plurality of first internal mounting positions sequentially pass through the first internal loading / unloading position. The first storage outer plate is configured to form a plurality of first external mounting positions for supporting reagent containers along the circumferential direction of the first pivot center, and the first storage outer plate rotates such that the plurality of first external mounting positions sequentially pass through the first external loading / unloading position. The second storage inner plate has a plurality of second internal mounting positions formed along the circumferential direction of the second pivot center for supporting reagent containers, and the second storage inner plate rotates so that the plurality of second internal mounting positions sequentially pass through the second internal loading / unloading position. The second storage outer plate is configured to form a plurality of second external mounting positions for supporting a plurality of reagent containers along the circumferential direction of the second pivot center, and the second storage outer plate rotates such that the plurality of second external mounting positions sequentially pass through the second external loading / unloading position. The temporary storage inner plate is configured to form a plurality of third internal mounting positions for supporting reagent containers along the circumferential direction of the third pivot center, and the temporary storage inner plate rotates so that the plurality of third internal mounting positions sequentially pass through the third internal loading / unloading position. The temporary storage outer plate is configured to form a plurality of third external mounting positions for supporting reagent containers along the circumferential direction of the third pivot center, and the temporary storage outer plate rotates such that the plurality of third external mounting positions sequentially pass through the third external loading / unloading position. The reagent container transfer mechanism is used to transfer a reagent container between a first inner insertion / removal position or a first outer insertion / removal position and the third inner insertion / removal position, or to transfer a reagent container between the first inner insertion / removal position or a first outer insertion / removal position and the third outer insertion / removal position, or to transfer a reagent container between the second inner insertion / removal position or a second outer insertion / removal position and the third inner insertion / removal position, or to transfer a reagent container between the second inner insertion / removal position or a second outer insertion / removal position and the third outer insertion / removal position.
[0010] Furthermore, the third loading / unloading position includes a third left loading / unloading position closer to the first reagent container storage mechanism and a third right loading / unloading position closer to the second reagent container storage mechanism, and the reagent container transfer mechanism transfers reagent containers between the first loading / unloading position and the third left loading / unloading position, and between the second loading / unloading position and the third right loading / unloading position.
[0011] Furthermore, a vertical symmetry line is formed that passes through the fourth rotation center and is perpendicular to the center line, and the third rotation center is offset from the vertical symmetry line and is close to the first reagent container storage mechanism or close to the second reagent container storage mechanism.
[0012] Furthermore, the vertical symmetry line and the vertical foot of the center line are located at the midpoint of the center line.
[0013] Furthermore, the reagent container transfer mechanism is A device for inserting and removing reagent containers, A rotary drive device for driving the rotation of the aforementioned retraction device, A lifting drive device for driving the aforementioned loading / unloading device to move up and down, Includes a horizontal drive device, The horizontal drive device drives the retraction device to move along the transfer path between the first retraction position and the third retraction position, and between the second retraction position and the third retraction position.
[0014] Furthermore, the insertion / removal device is a clip, or the insertion / removal device is a suction nozzle, and the suction nozzle is provided off-center from the rotation axis of the rotary drive device.
[0015] Furthermore, the first reagent container storage mechanism is configured to form a plurality of first mounting positions for supporting reagent containers along the circumferential direction of the first pivot center, and the first reagent container storage mechanism rotates such that the plurality of first mounting positions sequentially pass through the first loading / unloading position. The second reagent container storage mechanism is configured to form a plurality of second mounting positions for supporting reagent containers along the circumferential direction of the second pivot center, and the second reagent container storage mechanism rotates such that the plurality of second mounting positions sequentially pass through the second loading / unloading position. The reagent container temporary storage mechanism is configured to form a plurality of third mounting positions for supporting reagent containers along the circumferential direction of the third pivot center, and the reagent container temporary storage mechanism rotates so that the plurality of third mounting positions sequentially pass through the third loading / unloading position. The reagent container transfer mechanism is used to transfer a reagent container between a first insertion / removal position and a third insertion / removal position, or between a second insertion / removal position and a third insertion / removal position.
[0016] Furthermore, a horizontal line of symmetry is formed that passes through the fourth pivot center and is parallel to the center line. The aforementioned sample analyzer further comprises a sample transport mechanism for transporting sample containers. The center line and the specimen transport mechanism are respectively located on both sides of the horizontal symmetry line.
[0017] Furthermore, it further includes a collection box, and the collection port of the collection box is provided below the transfer path.
[0018] Furthermore, the collection port is located between the first reagent container storage mechanism and the reagent container temporary storage mechanism, or the collection port is located between the second reagent container storage mechanism and the reagent container temporary storage mechanism.
[0019] Furthermore, the reaction disk can carry a plurality of reaction vessels and includes a first reagent discharge position, a second reagent discharge position, a third reagent discharge position, and a fourth reagent discharge position. The first reagent container storage mechanism includes a first reagent suction position and a second reagent suction position. The second reagent container storage mechanism includes a third reagent suction position and a fourth reagent suction position. The specimen analyzer further includes a first reagent injection mechanism and a second reagent injection mechanism. The first reagent injection mechanism includes a first reagent needle and a second reagent needle that operate independently. The first reagent needle is used to suck a reagent from a reagent container at the first reagent suction position and transfer and inject it into a reaction vessel located at the first reagent discharge position along a first straight line. The second reagent needle is used to suck a reagent from a reagent container at the second reagent suction position and transfer and inject it into a reaction vessel located at the second reagent discharge position along a second straight line. The second reagent injection mechanism includes a third reagent needle and a fourth reagent needle that operate independently. The third reagent needle is used to suck a reagent from a reagent container at the third reagent suction position and transfer and inject it into a reaction vessel located at the third reagent discharge position along a third straight line. The fourth reagent needle is used to aspirate a reagent from the reagent container at the fourth reagent aspiration position and to transfer and inject it along the fourth straight line into the reaction vessel located at the fourth reagent discharge position. [Effects of the Invention]
[0020] In this invention, the first rotation center and the second rotation center are connected to form the aforementioned center line, the reagent container temporary storage mechanism and the reaction disk are provided on both sides of the center line, and the reagent container transfer mechanism is arranged to transfer reagent containers between the first reagent container storage mechanism and the reagent container temporary storage mechanism, and / or between the second reagent container storage mechanism and the reagent container temporary storage mechanism. This allows for the installation of multiple mechanisms, such as the reagent container temporary storage mechanism, the reaction disk, the first reagent container storage mechanism and the second reagent container storage mechanism, within a limited space, while simultaneously enabling uninterrupted loading of reagent containers by two reagent container storage mechanisms within that limited space. [Brief explanation of the drawing]
[0021] The drawings described herein are intended to provide a further understanding of the present application, which constitutes a part of the present application. Exemplary embodiments and descriptions of the present application are for interpretive purposes and do not constitute an unreasonable limitation to the present application. In the drawings, [Figure 1] This is a schematic diagram of the sample analyzer in one embodiment disclosed in this application. [Figure 2] This is a schematic diagram of the sample analyzer in another embodiment disclosed in this application. [Figure 3] This is a schematic diagram of a reagent container loading module in one embodiment disclosed in this application. [Figure 4] This is a schematic diagram of a partial structure of the first reagent injection mechanism in one embodiment disclosed in this application. [Modes for carrying out the invention]
[0022] In cases where there is no conflict, the embodiments and features described herein may be combined with each other. The present invention will now be described in detail with reference to the drawings, in accordance with the embodiments.
[0023] Furthermore, the terms used herein are not intended to limit the exemplary embodiments provided here, but are used solely to describe specific embodiments. As used herein, singular forms are also intended to include plural forms unless the context specifically indicates otherwise. In addition, when the terms “includes” and / or “contains” are used herein, it should be understood that features, steps, operations, devices, components, and / or combinations thereof are present.
[0024] The relative arrangements of components and steps, numerical formulas, and numerical values described in these embodiments do not limit the scope of the present invention unless otherwise specified. It goes without saying that the dimensions of the parts shown in the drawings are not depicted in actual proportions for illustrative purposes. While technologies, methods, and apparatus known to the general articulate to those skilled in the relevant field may not be discussed in detail, where appropriate, such technologies, methods, and apparatus should be considered part of the licensed specification. In all examples shown and discussed herein, specific numerical values should be considered illustrative and not restrictive. Therefore, other examples of the exemplary embodiments may have different values. Similar symbols and letters represent similar terms in the following drawings; therefore, once a term is defined in a drawing, it does not need to be discussed further in the next drawing.
[0025] As shown in Figures 1 to 3, the sample analyzer 100 according to the present invention includes a reaction disk 20 provided on a stage 10, and a first reagent container storage mechanism 31 and a second reagent container storage mechanism 32 provided on the outside of the reaction disk 20.
[0026] The first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 each carry a reagent container 40. The reagent container 40 contains reagents for detection tailored to the sample.
[0027] The first reagent container storage mechanism 31 is used to support multiple types of reagent containers. The second reagent container storage mechanism 32 is also used to support multiple types of reagent containers.
[0028] Furthermore, the reagent in the reagent container supported by the first reagent container storage mechanism 31 and the reagent in the reagent container supported by the second reagent container storage mechanism 32 may be the same or different.
[0029] The aforementioned sample analyzer 100 further includes a reagent container temporary storage mechanism 51. The reagent container temporary storage mechanism 51 is for supporting the reagent container 40 and is located between the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32.
[0030] The aforementioned sample analyzer 100 further includes a reagent container transfer mechanism 52. The reagent container transfer mechanism 52 transfers reagent containers 40 between the first reagent container storage mechanism 31 and the reagent container storage mechanism 51, and / or between the second reagent container storage mechanism 32 and the reagent container storage mechanism 51, thereby enabling uninterrupted loading of reagents by the first reagent container storage mechanism 31 and / or the second reagent container storage mechanism 32.
[0031] Furthermore, a center line 200 is formed to connect the first rotation center 315 of the first reagent container storage mechanism 31 and the second rotation center 325 of the second reagent container storage mechanism 32.
[0032] The third rotational center 515 of the reagent container temporary storage mechanism 51 and the fourth rotational center 21 of the reaction disk 20 are located on either side of the center line 200, respectively.
[0033] Since the reaction disk 20 needs to rotate to perform different detection operations at different operating positions, both the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 need to rotate to facilitate reagent collection.
[0034] Therefore, after mounting the reaction disk 20, the first reagent container storage mechanism 31, and the second reagent container storage mechanism 32 onto the stage 10, the available space between the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 is limited, and the reagent container storage mechanism 51 cannot be mounted on the aforementioned center line 200 with respect to the third pivot center 515.
[0035] Therefore, by arranging the reagent container transfer mechanism 52 to transfer reagent containers 40 between the first reagent container storage mechanism 31 and the reagent container storage mechanism 51, and / or between the second reagent container storage mechanism 32 and the reagent container storage mechanism 51, the reagent containers 40 can be loaded simultaneously and without interruption by the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 within a limited space.
[0036] As shown in Figure 2, in the first embodiment, the first reagent container storage mechanism 31 has a single-ring structure and has a first insertion / removal position 314 corresponding to the transfer path 300 of the reagent container transfer mechanism 52. The first reagent container storage mechanism 31 rotates around a first pivot center 315, thereby allowing the reagent container 40 supported thereon to pass through the first insertion / removal position 314.
[0037] The second reagent container storage mechanism 32 has a single-ring structure and has a second loading / unloading position 324 corresponding to the transfer path 300. The second reagent container storage mechanism 32 rotates around the second pivot center 325, thereby allowing the reagent container 40 supported thereon to pass through the second loading / unloading position 324.
[0038] The reagent container temporary storage mechanism 51 has a single-ring structure and has a third loading / unloading position 514 corresponding to the transfer path 300. By rotating the reagent container temporary storage mechanism 51 around the third pivot center 515, the reagent container 40 supported thereon can be passed to the third loading / unloading position 514.
[0039] The reagent container transfer mechanism 52 is able to transfer the reagent container 40 between the first insertion / removal position 314 and the third insertion / removal position 514 and / or between the second insertion / removal position 324 and the third insertion / removal position 514, so that the first insertion / removal position 314, the second insertion / removal position 324 and the third insertion / removal position 514 are each located below the transfer path 300.
[0040] Furthermore, with respect to the single-ring structure of the first reagent container storage mechanism 31, the first contact point where the transfer path 300 and the first reagent container storage mechanism 31 come into contact is the aforementioned first insertion / removal position 314. Alternatively, the two first intersections where the transfer path 300 and the first reagent container storage mechanism 31 intersect are each the aforementioned first insertion / removal position 314. That is, the first insertion / removal position 314 includes the first left insertion / removal position, which is the first intersection along the transfer path 300 that moves away from the second reagent container storage mechanism 32, and the first right insertion / removal position, which is the first intersection along the transfer path 300 that is closer to the second reagent container storage mechanism 32.
[0041] Regarding the second reagent container storage mechanism 32 having a single-ring structure, the second contact point where the transfer path 300 and the second reagent container storage mechanism 32 come into contact is the second insertion / removal position 324 described above. Alternatively, the two second intersections where the transfer path 300 and the second reagent container storage mechanism 32 intersect are each the second insertion / removal position 324 described above. That is, the second insertion / removal position 324 includes the second left insertion / removal position, which is the second intersection closer to the first reagent container storage mechanism 31 along the transfer path 300, and the second right insertion / removal position, which is the second intersection further away from the first reagent container storage mechanism 31 along the transfer path 300.
[0042] For the single-ring reagent container temporary storage mechanism 51, the third contact point where the transfer path 300 and the reagent container temporary storage mechanism 51 meet is the aforementioned third loading / unloading position 514. Alternatively, the two third intersections where the transfer path 300 and the reagent container temporary storage mechanism 51 intersect are each the aforementioned third loading / unloading position 514. That is, the third loading / unloading position 514 includes the third left loading / unloading position 5141 and the third right loading / unloading position 5142. The third left loading / unloading position 5141 is the third intersection along the transfer path 300 that is close to the first reagent container storage mechanism 31. The third right loading / unloading position 5142 is the third intersection along the transfer path 300 that is close to the second reagent container storage mechanism 32.
[0043] In the first embodiment, the reagent container transfer mechanism 52 can transfer the reagent container 40 between the first insertion / removal position 314 when they are in contact with each other, and between the aforementioned first left insertion / removal position or first right insertion / removal position and the aforementioned third left insertion / removal position 5141 when they are intersecting.
[0044] In the second embodiment, the reagent container transfer mechanism 52 can transfer the reagent container 40 between the aforementioned first insertion / removal position 314 when they are in contact with each other, and between the aforementioned first left insertion / removal position or first right insertion / removal position and the aforementioned third right insertion / removal position 5142 when they are intersecting.
[0045] In the third embodiment, the reagent container transfer mechanism 52 can transfer the reagent container 40 between the aforementioned second insertion / removal position 324 when they are in contact with each other, and between the aforementioned second left insertion / removal position or second right insertion / removal position and the aforementioned third left insertion / removal position 5141 when they are intersecting.
[0046] In the fourth embodiment, the reagent container transfer mechanism 52 can transfer the reagent container 40 between the aforementioned second insertion / removal position 324 when they are in contact with each other, and between the aforementioned second left insertion / removal position or second right insertion / removal position and the aforementioned third right insertion / removal position 5142 when they are intersecting.
[0047] In the fifth embodiment, the reagent container transfer mechanism 52 can transfer the reagent container 40 between the aforementioned first insertion / removal position 314 when they are in contact with each other, the aforementioned first left insertion / removal position or the aforementioned first right insertion / removal position when they are intersecting, and the aforementioned second insertion / removal position 324 when they are in contact with each other, the aforementioned second left insertion / removal position or the aforementioned second right insertion / removal position when they are intersecting.
[0048] Preferably, when the aforementioned transfer path 300 intersects with the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51, the reagent container transfer mechanism 52 transfers the reagent container 40 between the aforementioned first right loading / unloading position and the aforementioned third left loading / unloading position 5141. This shortens the transfer path of the reagent container transfer mechanism 52 between the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51, thereby improving the transfer efficiency of the reagent container 40. Furthermore, by reducing the time that the reagent container 40, which is in a low-temperature state, is exposed to the external environment, the influence of the external environment temperature on the reagent contained in the transferred reagent container 40 is reduced.
[0049] When the transfer path 300 intersects with the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51, the reagent container transfer mechanism 52 transfers the reagent container 40 between the second left loading / unloading position and the third right loading / unloading position 5142. This shortens the transfer path of the reagent container transfer mechanism 52 between the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51, thereby improving the transfer efficiency of the reagent container 40. Furthermore, by reducing the time that the reagent container 40, which is in a low-temperature state, is exposed to the external environment, the influence of the external environment temperature on the reagent contained in the transferred reagent container 40 is reduced.
[0050] Furthermore, the first reagent container storage mechanism 31 is configured to form a plurality of first placement positions 311 for placing the reagent container 40 along the circumferential direction of the first pivot center 315. The first reagent container storage mechanism 31 rotates so that the plurality of first placement positions 311 sequentially pass through the first insertion / removal position 314. Here, the first insertion / removal position 314 may be a first insertion / removal position 314 in a state where they are in contact with each other, or it may be the aforementioned first left insertion / removal position or the aforementioned first right insertion / removal position in a state where they intersect.
[0051] Regarding the first reagent container storage mechanism 31 having a single-ring structure, the first reagent container storage mechanism 31 is configured to form a plurality of the aforementioned first placement positions 311 along the first rotation path.
[0052] The first loading / unloading position 314 is located in the first rotation path described above. The first reagent container storage mechanism 31 rotates to move the target first placement position 311 to the first loading / unloading position 314. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target first placement position 311 located at the first loading / unloading position 314, or it may pick up a reagent container 40 placed at the target first placement position 311 located at the first loading / unloading position 314 and transfer it.
[0053] The second reagent container storage mechanism 32 is configured to form a plurality of second placement positions 321 for placing the reagent container 40 along the circumferential direction of the second pivot center 325. The aforementioned second reagent container storage mechanism 32 rotates so that the plurality of second placement positions 321 sequentially pass through the second insertion / removal position 324. Here, the second insertion / removal position 324 may be a second insertion / removal position 324 in a state where they are in contact with each other, or it may be the aforementioned second left insertion / removal position or the aforementioned second right insertion / removal position in a state where they intersect.
[0054] The second reagent container storage mechanism 32, which has a single-ring structure, is configured to form a plurality of second mounting positions 321 along the second rotation path.
[0055] The second loading / unloading position 324 is located in the second rotation path described above. The second reagent container storage mechanism 32 rotates to move the target second placement position 321 to the second loading / unloading position 324. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target second placement position 321 located at the second loading / unloading position 324, or it may pick up a reagent container 40 placed at the target second placement position 321 located at the second loading / unloading position 324 and transfer it.
[0056] The reagent container temporary storage mechanism 51 is configured to form a plurality of third placement positions 511 for placing reagent containers 40 along the circumferential direction of the third pivot center 515. The reagent container temporary storage mechanism 51 rotates so that the plurality of third placement positions 511 sequentially pass through the third insertion / removal position 514. Here, the third insertion / removal position 514 may be a third insertion / removal position 514 that is in contact with each other, or it may be the aforementioned third left insertion / removal position 5141 or the aforementioned third right insertion / removal position 5142 that are intersecting.
[0057] Regarding the reagent container temporary storage mechanism 51 having a single-ring structure, the reagent container temporary storage mechanism 51 is configured to form a plurality of third placement positions 511 along a third rotational path.
[0058] The third loading / unloading position 514 is located in the aforementioned third rotation path. The reagent container temporary storage mechanism 51 rotates to move the target third placement position 511 to the third loading / unloading position 514. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target third placement position 511 located at the third loading / unloading position 514, or it may pick up a reagent container 40 placed at the target third placement position 511 located at the third loading / unloading position 514 and transfer it.
[0059] Refer again to Figure 1. In the second embodiment, the first reagent container storage mechanism 31 has a double-ring structure and includes a first storage inner plate 312 and a first storage outer plate 313. The first storage inner plate 312 is located inside the first storage outer plate 313.
[0060] The first storage inner panel 312 has a first inner loading / unloading position 3122 corresponding to the transfer path 300 of the reagent container transfer mechanism 52. The first storage inner panel 312 rotates around the first pivot center 315, allowing the reagent containers 40 supported thereon to pass sequentially through the first inner loading / unloading position 3122.
[0061] The first storage outer panel 313 has a first outer loading / unloading position 3132 corresponding to the transfer path 300. The first storage outer panel 313 rotates around the first pivot center 315, allowing the reagent containers 40 supported thereon to pass sequentially through the first outer loading / unloading position 3132.
[0062] The second reagent container storage mechanism 32 has a double-ring structure and includes a second storage inner plate 322 and a second storage outer plate 323. The second storage inner plate 322 is located inside the second storage outer plate 323.
[0063] The second storage inner panel 322 has a second inner loading / unloading position 3222 corresponding to the transfer path 300. By rotating the second storage inner panel 322 around the second pivot center 325, the reagent container 40 supported thereon can be driven through the second inner loading / unloading position 3222.
[0064] The second storage outer panel 323 has a second external loading / unloading position 3232 corresponding to the transfer path 300. By rotating the second storage outer panel 323 around the second pivot center 325, the reagent container 40 supported thereon can be driven through the second external loading / unloading position 3232.
[0065] The reagent container temporary storage mechanism 51 has a double-ring structure and includes a temporary storage inner plate 512 and a temporary storage outer plate 513. The temporary storage inner plate 512 is located inside the temporary storage outer plate 513.
[0066] The temporary storage inner panel 512 has a third inner loading / unloading position 5122 corresponding to the transfer path 300. By rotating the temporary storage inner panel 512 around the third pivot center 515, the reagent container 40 supported thereon can be driven through the third inner loading / unloading position 5122.
[0067] The temporary storage outer plate 513 has a third external loading / unloading position 5132 corresponding to the transfer path 300. The temporary storage outer plate 513 can rotate around a third pivot center 515, allowing the reagent container 40 supported thereon to be driven through the third external loading / unloading position 5132.
[0068] The first internal loading / unloading position 3122, the first external loading / unloading position 3132, the second internal loading / unloading position 3222, the second external loading / unloading position 3232, the third internal loading / unloading position 5122, and the third external loading / unloading position 5132 are each located below the transfer path 300. The reagent container transfer mechanism 52 is used to transfer the reagent container 40 between the first internal loading / unloading position 3122 or the first external loading / unloading position 3132 and the third internal loading / unloading position 5122 or the third external loading / unloading position 5132, and / or it may be used to transfer the reagent container 40 between the second internal loading / unloading position 3222 or the second external loading / unloading position 3232 and the third internal loading / unloading position 5122 or the third external loading / unloading position 5132.
[0069] In other embodiments, the first reagent container storage mechanism 31 may be a single-ring structure, a double-ring structure, or a polycyclic structure having at least three rings. The second reagent container storage mechanism 32 may be a single-ring structure, a double-ring structure, or a polycyclic structure having at least three rings. The reagent container temporary storage mechanism 51 may be a single-ring structure, a double-ring structure, or a polycyclic structure having at least three rings. Further explanation is not provided here.
[0070] In one embodiment, the transfer path 300 is a single-stage and parallel to the center line 200 so that the reagent container transfer mechanism 52 can more efficiently transfer reagent containers between the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reagent container temporary storage mechanism 51.
[0071] Furthermore, the transfer path 300 of the reagent container transfer mechanism 52 is either parallel to the center line 200, intersects with the center line 200, or intersects with the extension of the center line 200.
[0072] Preferably, the transfer path 300 is parallel to the center line 200 so that the reagent container transfer mechanism 52 can efficiently transfer the reagent container 40 between the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51 over the shortest transfer distance, and / or transfer the reagent container 40 between the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51.
[0073] In another embodiment, the transfer path 300 includes at least two sub-transfer paths that are connected to each other. At least one sub-transfer path is not located on the same straight line as another adjacent sub-transfer path.
[0074] Specifically, in this embodiment, with respect to the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reagent container temporary storage mechanism 51, which have a single-ring structure, the aforementioned sub-transfer path includes a sub-transfer path between the third loading / unloading position 514 and the first loading / unloading position 314 and the second loading / unloading position 324.
[0075] Here, the first insertion / removal position 314 may be the aforementioned first contact or any of the aforementioned first intersections, the second insertion / removal position 324 may be the aforementioned second contact or any of the aforementioned second intersections, and the third insertion / removal position 514 may be the aforementioned third contact or any of the aforementioned third intersections.
[0076] With respect to the double-ring structure of the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reagent container temporary storage mechanism 51, in this embodiment, the aforementioned sub-transfer path is the sub-transfer path between the third inner loading / unloading position 5122 and the first inner loading / unloading position 3122 or the first outer loading / unloading position 3132 or the second inner loading / unloading position 3222 or the second outer loading / unloading position 3232 or the third outer loading / unloading position 5132, and between the third outer loading / unloading position 5132 and the first inner loading / unloading position 3122 or the first outer loading / unloading position The system includes sub-transfer paths between 3132 or the second inner retraction position 3222 or the second outer retraction position 3232, sub-transfer paths between the first inner retraction position 3122 and the first outer retraction position 3132 or the second inner retraction position 3222 or the second outer retraction position 3232, sub-transfer paths between the first outer release position 3132 and the second inner retraction position 3222 or the second outer retraction position 3232, and sub-transfer paths between the second inner retraction position 3222 and the second outer retraction position 3232.
[0077] Here, the first inner insertion / removal position 3122 may be the first contact point or any of the first inner intersections, the first outer insertion / removal position 3132 may be any of the first outer points, the second inner insertion / removal position 3222 may be the second contact point or any of the second inner intersections, the second outer insertion / removal position 3232 may be any of the second outer points, the third inner insertion / removal position 5122 may be the third contact point or any of the third inner intersections, and the third outer insertion / removal position 5132 may be any of the third outer points.
[0078] Furthermore, in the double-ring structure of the first reagent container storage mechanism 31, the connection between the first inner insertion / removal position 3122 and the first rotation center 315, and the connection between the first outer insertion / removal position 3132 and the first rotation center 315, form a first narrow angle 400.
[0079] Specifically, the first contact point where the transfer path 300 and the first storage inner panel 312 make contact is the aforementioned first inner loading / unloading position 3122. Alternatively, the two first inner intersection points where the transfer path 300 and the first storage inner panel 312 intersect are each the aforementioned first inner loading / unloading position 3122.
[0080] The two first external points where the transfer path 300 and the first storage outer panel 313 intersect are the aforementioned first external loading / unloading positions 3132.
[0081] The aforementioned first narrow angle 400 may be the angle between any of the aforementioned first external points, the aforementioned first point of contact, and the aforementioned first pivot center 315, or it may be the angle between any of the aforementioned first external points, the aforementioned first internal intersection, and the aforementioned first pivot center 315.
[0082] Preferably, along the longitudinal direction of the transfer path 300, the first internal loading / unloading position 3122 is located near the first internal intersection of the second reagent container storage mechanism 32, and the first external loading / unloading position 3132 is located near the first external point of the second reagent container storage mechanism 32. This minimizes the transfer distance when the reagent container transfer mechanism 52 transfers the reagent container 40 between the first internal loading / unloading position 3122 or the first external loading / unloading position 3132 and the reagent container temporary storage mechanism 51, thereby improving the transfer efficiency of the reagent container 40.
[0083] In the double-ring structure of the second reagent container storage mechanism 32, the connection between the second inner insertion / removal position 3222 and the second pivot center 325, and the connection between the second outer insertion / removal position 3232 and the second pivot center 325, form a second narrow angle 500.
[0084] Specifically, the second contact point where the transfer path 300 contacts the second storage inner panel 322 is the aforementioned second storage inner panel 3222. Alternatively, the two second internal intersection points where the transfer path 300 intersects with the second storage inner panel 322 are each the aforementioned second internal loading / unloading positions 3222.
[0085] The two second external points where the transfer path 300 and the second storage outer panel 323 intersect are the aforementioned second external loading / unloading positions 3232.
[0086] The aforementioned second narrow angle 500 may be the angle between any of the aforementioned second external points, the aforementioned second point of contact, and the aforementioned second pivot center 325, or it may be the angle between any of the aforementioned second external points, the aforementioned second internal intersection, and the aforementioned second pivot center 325.
[0087] Preferably, along the longitudinal direction of the transfer path 300, the second internal loading / unloading position 3222 is located closer to the second internal intersection of the first reagent container storage mechanism 31, and the second external loading / unloading position 3232 is located closer to the second external point of the first reagent container storage mechanism 31. This minimizes the transfer distance when the reagent container transfer mechanism 52 transfers the reagent container 40 between the second internal loading / unloading position 3222 or the second external loading / unloading position 3232 and the reagent container temporary storage mechanism 51, thereby improving the transfer efficiency of the reagent container 40.
[0088] In the double-ring reagent container temporary storage mechanism 51, the connection between the third inner insertion / removal position 5122 and the third pivot center 515, and the connection between the third outer insertion / removal position 5132 and the third pivot center 515, form a third narrow angle 600.
[0089] Specifically, the third contact point where the transfer path 300 contacts the temporary storage inner panel 512 is the third internal loading / unloading position 5122. Alternatively, the two third internal intersection points where the transfer path 300 intersects with the temporary storage inner panel 512 are each the aforementioned third internal loading / unloading position 5122.
[0090] The two third external points where the transfer path 300 and the temporary storage outer panel 513 intersect are the aforementioned third external insertion / removal positions 5132.
[0091] The aforementioned third angle 600 may be the angle between any of the aforementioned third external points, the aforementioned third point of contact, and the aforementioned third pivot center 515, or it may be the angle between any of the aforementioned third external points, the aforementioned third internal point, and the aforementioned third pivot center 515.
[0092] Furthermore, the openings of the first angle 400 and the second angle 500 face the reagent container temporary storage mechanism 51 and are located away from the reaction disk 20, and the opening of the third angle 600 faces the reaction disk 20, so the third pivot center 515 is located on the side of the transfer path 300 away from the reaction disk 20. This allows the aforementioned reagent container temporary storage mechanism to be integrated into the stage 10 and positioned in the void formed by the first reagent container storage mechanism 31, the second reagent container storage mechanism 32 and the reaction disk 20, and the reagent container temporary storage mechanism 51 to be placed on one side of the sample analyzer 100. Therefore, it becomes easier for the operator to insert and remove the reagent container 40 into and out of the reagent container temporary storage mechanism 51.
[0093] In one embodiment, when the reagent container transfer mechanism 52 transfers the reagent container 40 between the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51 along the length of the transfer path 300, the third inner loading / unloading position 5122 is located near the third inner intersection of the second reagent container storage mechanism 32, and the third outer loading / unloading position 5132 is located near the third outer point of the second reagent container storage mechanism 32. As a result, the transfer distance when the reagent container transfer mechanism 52 transfers the reagent container 40 between the second inner loading / unloading position 3222 or the second outer loading / unloading position 3232 and the reagent container temporary storage mechanism 51 is minimized, and the transfer efficiency of the reagent container 40 is improved.
[0094] In one embodiment, both the third internal loading / unloading position 5122 and the third external loading / unloading position 5132 are located either on the side closer to the first reagent container storage mechanism 31 or on the side closer to the second reagent container storage mechanism 32. This allows the reagent container temporary storage 51 to share a single reagent container loading / unloading port corresponding to the third internal loading / unloading position 5122 and the third external loading / unloading position 5132, thereby effectively controlling the size of the reagent container loading / unloading port. This reduces temperature convection between the lumen of the reagent container temporary storage mechanism 51 and the outside environment when transferring reagent containers, and further reduces the impact of temperature changes during the transfer of reagent containers on the reagent containers stored in the reagent container temporary storage mechanism 51.
[0095] Along the length of the transfer path 300, when the reagent container transfer mechanism 52 transfers the reagent container 40 between the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51, the third internal loading / unloading position 5122 is located near the third internal intersection of the first reagent container storage mechanism 31, and the third external loading / unloading position 5132 is located near the third external point of the first reagent container storage mechanism 31. As a result, the transfer distance when the reagent container transfer mechanism 52 transfers the reagent container 40 between the first internal loading / unloading position 3122 or the first external loading / unloading position 3132 and the reagent container temporary storage mechanism 51 is minimized, and the transfer efficiency of the reagent container 40 is improved.
[0096] Furthermore, in one embodiment, the center line 200 and the third rotation center 515 are located on opposite sides of the transfer path 300, respectively.
[0097] In another embodiment, the third pivot center 515 is located directly below the transfer path 300. That is, in a plan view, the third pivot center 515 is superimposed on the transfer path 300.
[0098] In other embodiments, the third rotation center 515 is located between the center line 200 and the transfer path 300.
[0099] Furthermore, the first storage inner panel 312 is configured to form a plurality of first internal placement positions 3121 for placing reagent containers 40 along the circumferential direction of the first rotation center 315. The first storage inner panel 312 rotates so that the plurality of first internal placement positions 3121 sequentially pass through the aforementioned first internal loading / unloading position 3122.
[0100] In the double-ring structure of the first reagent container storage mechanism 31, the first storage inner platen 312 is configured to form a plurality of the aforementioned first internal placement positions 3121 along the first internal rotation path.
[0101] The first internal loading / unloading position 3122 is located in the first internal rotation path described above. The first storage inner panel 312 rotates to move the target first internal placement position 3121 to the first internal loading / unloading position 3122. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target first internal placement position 3121 located at the first internal loading / unloading position 3122, or it may pick up a reagent container 40 placed at the target first internal placement position 3121 located at the first internal loading / unloading position 3122 and transfer it.
[0102] The first storage outer panel 313 forms a plurality of first external placement positions 3131 for placing reagent containers 40 along the circumferential direction of the first pivot center 315. The first storage outer panel 313 rotates so that the plurality of first external placement positions 3131 sequentially pass through the first external loading / unloading position 3132.
[0103] In the double-ring structure of the first reagent container storage mechanism 31, the first storage outer plate 313 is configured to form a plurality of the aforementioned first external mounting positions 3131 along the first external rotation path.
[0104] The first external loading / unloading position 3132 is located in the first external rotation path described above. The first storage outer panel 313 rotates to move the target first external placement position 3131 to the first internal loading / unloading position 3122. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target first external placement position 3131 located at the first external loading / unloading position 3132, or it may pick up a reagent container 40 placed at the target first external placement position 3131 located at the first external loading / unloading position 3132 and transfer it.
[0105] In one embodiment of the double-ring structure of the first reagent container storage mechanism 31, the first inner storage plate 312 and the first outer storage plate 313 rotate synchronously at the same rotational speed. That is, when the first inner storage plate 312 rotates, the first outer storage plate 313 also rotates synchronously with the first inner storage plate 312 at the same rotational speed. Alternatively, when the first outer storage plate 313 rotates, the first inner storage plate 312 also rotates synchronously with the first outer storage plate 313 at the same rotational speed.
[0106] In another embodiment, the first storage inner panel 312 and the first storage outer panel 313 rotate independently of each other. That is, when the first storage inner panel 312 rotates, the first storage outer panel 313 may remain stationary or rotate at the same or a different rotational speed as the first storage inner panel 312. Alternatively, when the first storage outer panel 313 rotates, the first storage inner panel 312 may remain stationary or rotate at the same or a different rotational speed as the first storage outer panel 313.
[0107] Furthermore, the second storage inner plate 322 is configured to form a plurality of second internal placement positions 3221 for placing reagent containers 40 along the circumferential direction of the second pivot center 325. The second storage inner plate 322 rotates so that the plurality of second internal placement positions 3221 sequentially pass through the second internal loading / unloading positions 3222.
[0108] With respect to the double-ring structure of the second reagent container storage mechanism 32, the second storage inner plate 322 is configured to form a plurality of the aforementioned second internal mounting positions 3221 along the second internal rotation path.
[0109] The second internal loading / unloading position 3222 is located in the second internal rotation path. The second storage inner panel 322 rotates to move the target second internal placement position 3221 to the second internal loading / unloading position 3222. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target second internal placement position 3221 located at the second internal loading / unloading position 3222, or it may pick up a reagent container 40 placed at the target second internal placement position 3221 located at the second internal loading / unloading position 3222 and transfer it.
[0110] The second storage outer plate 323 is configured to form a plurality of second external placement positions 3231 for placing reagent containers 40 along the circumferential direction of the second pivot center 325. The second storage outer plate 323 rotates so that the plurality of second external placement positions 3231 sequentially pass through the second external loading / unloading position 3232.
[0111] In the double-ring structure of the second reagent container storage mechanism 32, the second storage outer plate 323 is configured to form a plurality of second external mounting positions 3231 along the second external rotation path.
[0112] The second external loading / unloading position 3232 is located in the second external rotation path. The second storage outer panel 323 rotates to move the target second external placement position 3231 to the second internal loading / unloading position 3222. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target second external placement position 3231 located at the second external loading / unloading position 3232, or it may pick up a reagent container 40 placed at the target second external placement position 3231 located at the second external loading / unloading position 3232 and transfer it.
[0113] In one embodiment of the double-ring structure of the second reagent container storage mechanism 32, the second inner storage plate 322 rotates synchronously with the second outer storage plate 323 at the same rotational speed. That is, when the second inner storage plate 322 rotates, the second outer storage plate 323 also rotates synchronously with the second inner storage plate 322 at the same rotational speed. Alternatively, when the second outer storage plate 323 rotates, the second inner storage plate 322 also rotates synchronously with the second outer storage plate 323 at the same rotational speed.
[0114] In another embodiment, the second storage inner panel 322 and the second storage outer panel 323 rotate independently of each other. That is, when the second storage inner panel 322 rotates, the second storage outer panel 323 may remain stationary or rotate at the same or a different rotational speed as the second storage inner panel 322. Alternatively, when the second storage outer panel 323 rotates, the second storage inner panel 322 may remain stationary or rotate at the same or a different rotational speed as the second storage outer panel 323.
[0115] Furthermore, the temporary storage inner plate 512 is configured to form a plurality of third internal placement positions 5121 for placing reagent containers 40 along the circumferential direction of the third rotation center 515. The temporary storage inner plate 512 rotates so that the plurality of third internal placement positions 5121 sequentially pass through the third internal loading / unloading position 5122.
[0116] In the reagent container temporary storage mechanism 51 with a double-ring structure, the temporary storage inner plate 512 is configured to form a plurality of the aforementioned third internal placement positions 5121 along the third internal rotation path.
[0117] The third internal loading / unloading position 5122 is located in the aforementioned third internal rotation path. The temporary storage inner plate 512 rotates to move the target third internal placement position 5121 to the third internal loading / unloading position 5122. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target third internal placement position 5121 located at the third internal loading / unloading position 5122, or it may pick up a reagent container 40 placed at the target third internal placement position 5121 located at the third internal loading / unloading position 5122 and transfer it.
[0118] The temporary storage outer plate 513 is configured to form a plurality of third external placement positions 5131 for placing reagent containers 40 along the circumferential direction of the third pivot center 515. The temporary storage outer plate 513 rotates so that the plurality of third external placement positions 5131 sequentially pass through the third external loading / unloading position 5132.
[0119] In the reagent container temporary storage mechanism 51 with a double-ring structure, the temporary storage outer plate 513 is configured to form a plurality of the aforementioned third external mounting positions 5131 along the third external rotation path.
[0120] The third external loading / unloading position 5132 is located in the third external rotation path. The temporary storage outer plate 513 rotates to move the target third external placement position 5131 to the third internal loading / unloading position 5122. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target third external loading / unloading position 5131 located in the third external loading / unloading position 5132, or it may pick up a reagent container 40 placed at the target third external loading / unloading position 5131 located in the third external loading / unloading position 5132 and transfer it.
[0121] In one embodiment of the double-ring reagent container temporary storage mechanism 51, the temporary storage inner plate 512 and the temporary storage outer plate 513 rotate synchronously at the same rotational speed. That is, when the temporary storage inner plate 512 rotates, the temporary storage outer plate 513 also rotates synchronously with the temporary storage inner plate 512 at the same rotational speed. Alternatively, when the temporary storage outer plate 513 rotates, the temporary storage inner plate 512 also rotates synchronously with the temporary storage outer plate 513 at the same rotational speed.
[0122] In another embodiment, the temporary storage inner platen 512 and the temporary storage outer platen 513 rotate independently of each other. That is, when the temporary storage inner platen 512 rotates, the aforementioned temporary storage outer platen 513 may remain stationary or rotate at the same or a different rotational speed as the aforementioned temporary storage inner platen 512. Alternatively, when the aforementioned temporary storage outer platen 513 rotates, the aforementioned temporary storage inner platen 512 may remain stationary or rotate at the same or a different rotational speed as the aforementioned temporary storage outer platen 513.
[0123] Accordingly, as described above, with respect to the double-ring structure of the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reagent container temporary storage mechanism 51, the aforementioned reagent container transfer mechanism 52 is used to transfer the reagent container 40 between the first inner insertion / removal position 3122 or the first outer insertion / removal position 3132 and the aforementioned third inner insertion / removal position 5122. Alternatively, the aforementioned reagent container transfer mechanism 52 is used to transfer the reagent container 40 between the first inner insertion / removal position 3122 or the first outer insertion / removal position 3132 and the aforementioned third outer insertion / removal position 5132. Alternatively, the aforementioned reagent container transfer mechanism 52 is used to transfer the reagent container 40 between the second inner insertion / removal position 3222 or the second outer insertion / removal position 3232 and the aforementioned third inner insertion / removal position 5122. Alternatively, the aforementioned reagent container transfer mechanism 52 is used to transfer the reagent container 40 between the second internal insertion / removal 3222 or the second external insertion / removal 3232 and the aforementioned third external insertion / removal position 5132.
[0124] Furthermore, in some embodiments, the reagent container transfer mechanism 52 may be used to transfer the reagent container 40 between the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32.
[0125] Furthermore, a vertical symmetry line 700 is formed that passes through the aforementioned fourth rotation center 21 and is perpendicular to the aforementioned center line 200. The aforementioned third rotation center 515 moves away from the vertical symmetry line 700 and approaches the first reagent container storage mechanism 31 or the second reagent container storage mechanism 32.
[0126] Specifically, after the reaction disk 20 is attached to the stage 10 with the fourth rotation center 21 as the reference point, and the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 are attached with the reaction disk 20 as the reference point, the available space remaining between the reaction disk 20 and the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 is limited. Therefore, after the reagent container temporary storage mechanism 51 is attached to the stage 10 with the third rotation center 515 as the reference point, the aforementioned third rotation center 515 moves away from the aforementioned vertical symmetry line 700 and approaches either the first reagent container storage mechanism 31 or the second reagent container storage mechanism 32.
[0127] Furthermore, in one embodiment, the vertical foot of the vertical symmetry line 700 and the center line 200 is located at the midpoint of the center line 200.
[0128] Specifically, the first rotation center 315 and the second rotation center 325 are distributed symmetrically on both sides of the vertical symmetry line 700, such that the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 are symmetrically positioned on both sides of the vertical symmetry line 700. The first rotation center 315, the second rotation center 325, and the fourth rotation center 21 surround each other, forming an isosceles triangle.
[0129] Furthermore, a horizontal symmetry line 800 is formed that passes through the fourth rotation center 21 and is parallel to the aforementioned center line 200. The aforementioned sample analyzer 100 further comprises a sample transport mechanism 70 for transporting sample containers. The aforementioned center line 200 and the aforementioned sample transport mechanism 70 are located on opposite sides of the aforementioned horizontal symmetry line 800.
[0130] Specifically, the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reagent container temporary storage mechanism 51 are all located on the same side (one side) of the aforementioned horizontal symmetry line 800, while the sample transport mechanism 70 is located on the other side of the horizontal symmetry line 800. As a result, the operator can easily insert and remove the reagent containers 40 into and out of the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reagent container temporary storage mechanism 51, and the sample transport mechanism 70 can transport the sample containers smoothly.
[0131] Furthermore, the reagent container transfer mechanism 52 includes an insertion / removal device 521, a rotary drive device 522, a lifting drive device 523, and a horizontal drive device 524.
[0132] The loading / unloading device 521 is for loading and unloading the reagent container 40, and rotates along the axis of rotation under the drive of the rotary drive device 522.
[0133] Specifically, the dispensing device 521 can dispense and release reagents from the reagent container 40.
[0134] In one embodiment, the loading / unloading device 521 is a gripper for holding the reagent container 40 in order to transfer the reagent container 40. The gripper can adjust the angle at which it clamps or releases the reagent container 40 under the drive of a rotary drive device 522 in order to transfer the reagent container 40 more efficiently.
[0135] Specifically, since the transfer path 300 of the reagent container transfer mechanism 52 is located off-center from the aforementioned centerline 200, each insertion / removal position in the first reagent container storage mechanism 31 has a different phase angle with respect to the first rotation center 315, each insertion / removal position in the second reagent container storage mechanism 32 also has a different phase angle with respect to the second rotation center 325, and each insertion / removal position in the reagent container temporary storage mechanism 51 also has a different phase angle with respect to the third rotation center 515. Therefore, when the gripper clamps or releases the reagent container 40 at different insertion / removal positions, it is necessary to adjust the angle at which it clamps or releases under the drive of the rotary drive device 522.
[0136] In another embodiment, the dispensing device 521 is a suction nozzle. The suction nozzle is connected to a pump via a conduit. The pump operates and controls the suction nozzle via the aforementioned conduit to aspirate or release the reagent container 40.
[0137] Specifically, since the transfer path 300 of the reagent container transfer mechanism 52 is provided off-center from the aforementioned centerline 200, each insertion / removal position in the first reagent container storage mechanism 31 has a different phase angle with respect to the first rotation center 315, each insertion / removal position in the second reagent container storage mechanism 32 also has a different phase angle with respect to the second rotation center 325, and each insertion / removal position in the reagent container temporary storage mechanism 51 also has a different phase angle with respect to the third rotation center 515. Accordingly, the nozzle is provided off-center from the rotation axis of the rotary drive device 522 so that the reagent container 40 can be clamped or released at different insertion / removal positions.
[0138] The lifting drive device 523 is for driving the lifting and lowering of the loading / unloading device 521. The lifting drive device 523 allows the loading / unloading device 521 to descend to each loading / unloading position to load or unload the reagent container 40, and after picking up or releasing the reagent container 40, to move upward so as to move away from the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, or the reagent container temporary storage mechanism 51.
[0139] The horizontal drive device drives the loading / unloading device 521 to move it along the transfer path 300 between the first loading / unloading position 314 and the third loading / unloading position 514, thereby transferring the reagent container 40 between the reagent container temporary storage mechanism 51 and the first reagent container storage mechanism 31. The aforementioned horizontal drive device is also used to drive the loading / unloading device 521 to move it between the second loading / unloading position 324 and the third loading / unloading position 514, thereby transferring the reagent container 40 between the reagent container temporary storage mechanism 51 and the second reagent container storage mechanism 32.
[0140] Specifically, the horizontal drive device 524 drives the loading / unloading device 521 to move the reagent container 40 along the transfer path 300, or drives the loading / unloading device 521 to move along the transfer path 300 to reach the target loading / unloading position and pick up the reagent container 40.
[0141] In one embodiment, the loading / unloading device 521 is provided at the output terminal of the rotary drive device 522, the rotary drive device 522 is provided at the output terminal of the lifting drive device 523, and the lifting drive device 523 is provided at the output terminal of the horizontal drive device 524.
[0142] In another embodiment, the loading / unloading device 521 is provided at the output terminal of the lifting drive device 523, the lifting drive device 523 is provided at the output terminal of the rotary drive device 522, and the rotary drive device 522 is provided at the output terminal of the horizontal drive device 524.
[0143] Furthermore, the reagent container transfer mechanism 52 further includes a collection box 60. The collection port 61 of the collection box 60 is located below the transfer path 300. This allows the reagent container transfer mechanism 52 to discard the reagent containers 40 from the collection port 61 simply by moving along the transfer path 300. Thus, the movement path of the reagent container transfer mechanism 52 is simplified, the disposal of the reagent containers 40 is made easier, and the efficiency of loading the reagent containers 40 is improved.
[0144] The loading / unloading device 521 can also be moved above the collection port 61 by the drive of the horizontal drive device 524, and the reagent container 40 can be disposed of from the collection port 61 into the collection box 60, thereby achieving the recovery of the reagent container 40. Here, the recovered reagent container 40 may be an empty reagent container 40 or a reagent container 40 containing reagents.
[0145] Furthermore, in one embodiment, the recovery port 61 is located between the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51.
[0146] In another embodiment, the recovery port 61 is located between the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51.
[0147] Preferably, the collection port 61 and the third pivot center 515 are distributed on both sides of the vertical symmetry line 700 so that the collection box 60 and the reagent container temporary storage mechanism 51 are positioned on both sides of the vertical symmetry line 700. This allows the collection box 60 to be positioned by making full use of the gap between the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51, or the gap between the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51. Thus, the collection box 60 is compactly integrated into the sample analyzer 100 and is located away from the sample transport mechanism 70 of the sample analyzer 100. Consequently, the operator can easily take away the reagent containers 40 collected in the collection box 60.
[0148] Furthermore, the reaction disc 20 can accommodate multiple reaction vessels. These reaction vessels contain the sample (detection sample) and reagents injected from the first reagent container storage mechanism 31 and / or the second reagent container storage mechanism 32, and are used to incubate the mixture of the sample and reagents via the reaction disc 20.
[0149] Furthermore, the reaction disk 20 includes a first reagent dispensing position 22, a second reagent dispensing position 23, a third reagent dispensing position 24, and a fourth reagent dispensing position 25.
[0150] The first reagent container storage mechanism 31 includes a first reagent aspiration position 316 and a second reagent aspiration position 317.
[0151] As can be seen by referring together to Figures 1 and 4, the sample analyzer 100 further comprises a first reagent injection mechanism 91. The first reagent injection mechanism 91 is for transferring and injecting reagents from a reagent container 40 placed on the first reagent container storage mechanism 31 into a reaction vessel placed on the reaction disk 20.
[0152] The first reagent injection mechanism 91 includes a first reagent needle 911 and a second reagent needle that operate independently.
[0153] The first reagent needle 911 is used to aspirate a reagent from within the reagent container 40 located at either the first reagent aspiration position 316 or the second reagent aspiration position 317, and to discharge it along the first straight line 913 into the reaction vessel located at either the first reagent discharge position 22 or the second reagent discharge position 23.
[0154] The second reagent needle is used to aspirate a reagent from the reagent container 40 located at the other of the first reagent aspiration position 316 or the second reagent aspiration position 317, and to discharge it along the second straight line 914 into the reaction vessel located at the other of the first reagent discharge position 22 or the second reagent discharge position 23.
[0155] The reaction disk 20 rotates to move the two target reaction vessels to the first reagent dispensing position 22 and the second reagent dispensing position 23, respectively. Then, the first reagent container storage mechanism 31 rotates to move the two target reagent containers 40 to the first reagent aspiration position 316 and the second reagent aspiration position 317, respectively. After that, the first reagent needle 911 aspirates a reagent from one of the target reagent containers 40 located at either the first reagent aspiration position 316 or the second reagent aspiration position 317, and transports the aspirated reagent along the first straight line 913 to inject it into one of the target reaction vessels located at either the first reagent dispensing position 22 or the second reagent dispensing position 23.
[0156] The second reagent needle aspirates reagent from the target reagent container 40 located at the other of the first reagent aspiration position 316 or the second reagent aspiration position 317, and transfers the aspirated reagent along the second straight line 914 to inject it into the target reaction vessel located at the other of the first reagent discharge position 22 or the second reagent discharge position 23.
[0157] Compared to the reagent injection method of the conventional sample analyzer 100, this invention significantly improves the reagent injection efficiency into the reaction vessel by transferring reagents along the first straight line 913 with an independently operating first reagent needle 911 and transferring reagents along the second straight line 914 with an independently operating second reagent needle. This avoids the first and second reagent needles performing reagent aspiration and injection back and forth, and the transfer and reset of the aspirationed reagent while rotating. As a result, the reaction disk 20 waits for reagent injection by the first and second reagent needles, the first reagent container storage mechanism 31 waits for reagent aspiration by the first and second reagent needles, and the reagent transfer time and the reset time of the first and second reagent needles are reduced. Furthermore, the independently operating first and second reagent needles can be controlled to transfer reagents by controlling only the first or second reagent needle as needed.
[0158] Refer again to Figure 2. In one embodiment, the first reagent container storage mechanism 31 has a single-ring structure. Multiple first placement positions 311 transport the reaction vessel along the aforementioned first rotation path around the first rotation center 315.
[0159] Furthermore, as shown in Figure 1, in another embodiment, the first reagent container storage mechanism 31 has a double-ring structure, and the first storage inner plate 312 is configured to form a plurality of first internal placement positions 3121 along a first internal rotation path. Each of the aforementioned first internal placement positions 3121 can accommodate one reagent container 40.
[0160] The first storage outer panel 313 is configured to form a plurality of first external mounting positions 3131 along a first external rotation path. Each of the aforementioned first external mounting positions 3131 can accommodate one reagent container 40.
[0161] Furthermore, in a more specific embodiment, the first reagent aspiration position 316 is provided in the aforementioned first internal rotation path of the first storage inner platen 312. Multiple first internal placement positions 3121 move along the aforementioned first internal rotation path and sequentially pass through the first reagent aspiration position 316. The second reagent aspiration position 317 is provided in the aforementioned first external rotation path of the first storage outer platen 313. Multiple first external placement positions 3131 move along the aforementioned first external rotation path and sequentially pass through the second reagent aspiration position 317.
[0162] In another kind of more specific embodiment, the first reagent aspiration position 316 is provided in the aforementioned first external rotation path of the first storage outer plate 313, and a plurality of first external mounting positions 3131 move along the aforementioned first external rotation path and sequentially pass the first reagent aspiration position 316. The second reagent aspiration position 317 is provided in the aforementioned first internal rotation path of the first storage inner plate 312, and a plurality of the aforementioned first internal mounting positions 3121 move along the aforementioned first internal rotation path and sequentially pass the second reagent aspiration position 317.
[0163] In one embodiment, the first storage inner panel 312 and the first storage outer panel 313 maintain synchronous rotation.
[0164] In another embodiment, the first storage inner panel 312 is rotatable independently of the first storage outer panel 313. That is, when the first storage inner panel 312 rotates, the first storage outer panel 313 may remain stationary or rotate at the same or a different rotational speed as the first storage inner panel 312. Alternatively, when the first storage outer panel 313 rotates, the first storage inner panel 312 may remain stationary or rotate at the same or a different rotational speed as the first storage outer panel 313.
[0165] Furthermore, the independently rotatable first storage inner platen 312 can be controlled to directly move the target reagent container 40 to the first reagent aspiration position 316 or the second reagent aspiration position 317, which corresponds to the first reagent needle 911, depending on the type of reagent to be aspirated in the reagent container 40 placed at the first inner mounting position 3121.
[0166] The independently rotatable first storage outer plate 313 can control the target reagent container 40 to be directly moved to the second reagent aspiration position 317 or the first reagent aspiration position 316, which corresponds to the second reagent needle, depending on the type of reagent to be aspirated from the reagent container 40 placed at the first external mounting position 3131.
[0167] The independently rotatable first storage inner platen 312 and first storage outer platen 313 make it easier to aspirate reagents using the first reagent needle 911 and the second reagent needle from the first storage inner platen 312 and the first storage outer platen 313, which maintain synchronous rotation.
[0168] Furthermore, the reaction disk 20 includes an inner reaction tray 26 and an outer reaction tray 27. The inner reaction tray 26 is located inside the outer reaction tray 27.
[0169] The reaction inner tray 26 is configured to form a plurality of fourth internal mounting positions 261 along a fourth internal rotation path. Each fourth internal mounting position 261 can accommodate one reaction vessel.
[0170] The reaction outer tray 27 is configured to form a plurality of fourth external mounting positions 271 along a fourth external rotation path. Each fourth external mounting position 271 can accommodate one reaction vessel.
[0171] Furthermore, in a more specific embodiment, the first reagent dispensing position 22 is located in the aforementioned fourth internal rotation path of the reaction inner tray 26, and the multiple fourth internal placement positions 261 move along the aforementioned fourth internal rotation path and sequentially pass the first reagent dispensing position 22.
[0172] The second reagent dispensing position 23 is located in the aforementioned fourth external rotation path of the reaction outer tray 27, and the multiple fourth external mounting positions 271 move along the aforementioned fourth external rotation path and sequentially pass the aforementioned second reagent dispensing position 23.
[0173] In another kind of more specific embodiment, the first reagent dispensing position 22 is located in the aforementioned fourth external rotation path of the reaction outer tray 27, and a plurality of fourth external mounting positions 271 move along the aforementioned fourth external rotation path and sequentially pass the first reagent dispensing position 22.
[0174] The second reagent dispensing position 23 is located in the aforementioned fourth internal rotation path of the reaction inner tray 26, and the multiple fourth internal placement positions 261 move along the aforementioned fourth internal rotation path and sequentially pass through the second reagent dispensing position 23.
[0175] In one embodiment, the reaction inner tray 26 and the reaction outer tray 27 maintain synchronous rotation.
[0176] In another embodiment, the reaction inner tray 26 is rotatable independently of the reaction outer tray 27. That is, when the reaction inner tray 26 rotates, the reaction outer tray 27 may remain stationary or rotate at the same or a different speed as the reaction inner tray 26. Alternatively, when the reaction outer tray 27 rotates, the reaction inner tray 26 may remain stationary or rotate at the same or a different speed as the reaction outer tray 27.
[0177] Furthermore, the independently rotatable reaction inner tray 26 can be controlled to move directly to either the first reagent dispensing position 22 or the second reagent dispensing position corresponding to the first reagent needle 911, depending on the type of reagent to be injected into the reaction vessel placed at the fourth internal mounting position 261.
[0178] The independently rotatable reaction outer tray 27 can be controlled to move the target reaction vessel directly to the second reagent dispensing position or the first reagent dispensing position 22, which corresponds to the second reagent needle, depending on the type of reagent to be injected into the reaction vessel placed at the fourth external mounting position 271.
[0179] Having the reaction inner tray 26 and reaction outer tray 27 rotate independently makes it easier to inject reagents using the first reagent needle 911 and the second reagent needle, compared to keeping the reaction inner tray 26 and reaction outer tray 27 rotated synchronously.
[0180] Furthermore, by providing independently rotatable reaction inner tray 26 and reaction outer tray 27, and independently rotatable first storage inner plate 312 and first storage outer plate 313, and by injecting reagents placed on the first storage outer plate 313 into reaction vessels placed on the reaction inner tray 26 or reaction outer tray 27 using an independently operating first reagent needle 911, and injecting reagents placed on the first storage inner plate 312 into reaction vessels placed on the reaction outer tray 27 or reaction inner tray 26 using an independently operating second reagent needle, the sample analyzer 100 integrates two independent parallel reagent supply, dispensing, and detection systems, thereby effectively improving detection efficiency.
[0181] Furthermore, in one embodiment, a first centerline 200 is formed between the first rotation center 315 and the third rotation center 515. The first straight line 913 and the second straight line 914 are each parallel to the aforementioned first centerline 200.
[0182] Preferably, the distance from the first straight line 913 to the first centerline 200 is equal to the distance from the second straight line 914 to the first centerline 200.
[0183] Furthermore, the time required for the first reagent needle 911 to move along the first straight line 913 from the first reagent aspiration position 316 to the first reagent dispensing position 22 is the same as the time required for the second reagent needle to move along the second straight line 914 from the second reagent aspiration position 317 to the second reagent dispensing position.
[0184] Furthermore, in one embodiment, the first reagent needle 911 and the aforementioned second reagent needle are each provided on a stand at a certain distance apart.
[0185] Furthermore, the first reagent needle 911 is moved vertically by a lifting drive device 523 so that it can move up and down between one of the first reagent aspiration position 316 and the second reagent aspiration position 317, and between one of the first reagent discharge position 22 and the second reagent discharge position.
[0186] Furthermore, the first reagent needle 911 is moved horizontally along the direction of the first straight line 913 by a horizontal drive device so that it can move between the first reagent aspiration position 316 and the first reagent dispensing position 22 or the second reagent dispensing position, or between the second reagent aspiration position 317 and the aforementioned second reagent dispensing position or the first reagent dispensing position 22.
[0187] The aforementioned second reagent needle is moved vertically by a separate lifting drive device 523 so that it can move up and down between either the first reagent aspiration position 316 or the second reagent aspiration position 317, and between the first reagent discharge position 22 and the aforementioned second reagent discharge position.
[0188] Furthermore, the aforementioned second reagent needle is moved horizontally along the direction of the second straight line 914 by another horizontal drive device so that it can move between the first reagent aspiration position 316 and the first reagent dispensing position 22 or the second reagent dispensing position, or between the second reagent aspiration position 317 and the aforementioned second reagent dispensing position or the first reagent dispensing position 22.
[0189] In another embodiment, the first reagent needle 911 and the aforementioned second reagent needle are provided on the same stent. The first reagent needle 911 and the aforementioned second reagent needle each move vertically up and down by a single lifting drive device 523, and each moves horizontally along the corresponding first straight line 913 and second straight line 914 by a single horizontal drive device.
[0190] Furthermore, the reaction disk 20 further includes a third reagent dispensing position 24 and a fourth reagent dispensing position 25. By rotating around the fourth pivot center 21, the reaction disk 20 drives the multiple third mounting positions 511, allowing it to sequentially pass through the third reagent dispensing position 24 and the fourth reagent dispensing position 25.
[0191] The sample analyzer 100 further comprises a second reagent injection mechanism 92, which is for injecting reagents from a reagent container 40 placed on a second reagent container storage mechanism 32 into a reaction vessel placed on a reaction disk 20.
[0192] The second reagent container storage mechanism 32 is located outside the reaction disk 20 and can accommodate multiple reagent containers 40. The second reagent container storage mechanism 32 is rotatable so that the multiple reagent containers 40 move in conjunction along the second rotation path.
[0193] The second reagent container storage mechanism 32 is configured to form a plurality of second placement positions 321 along the second rotation path described above. Each second placement position 321 can accommodate one reagent container 40.
[0194] The second reagent container storage mechanism 32 includes a third reagent aspiration position 326 and a fourth reagent aspiration position 327. By rotating the second reagent container storage mechanism 32 around the second pivot center 325, the multiple second placement positions 321 can sequentially pass through the third reagent aspiration position 326 and the fourth reagent aspiration position 327.
[0195] The second reagent injection mechanism 92 includes a third reagent needle and a fourth reagent needle that operate independently. The third and fourth reagent needles have the same structure as the first reagent needle 911 and the second reagent needle described above.
[0196] The third reagent needle is used to aspirate reagents from the reagent container 40 located at either the third reagent aspiration position 326 or the fourth reagent aspiration position 327, and to transfer and inject the aspirated reagents along the third straight line 923 into the reaction vessel located at either the third reagent discharge position 24 or the fourth reagent discharge position 25.
[0197] The fourth reagent needle is used to aspirate reagents from the reagent container 40 located at the other of the third reagent aspiration position 326 or the fourth reagent aspiration position 327, and to transfer and inject the aspirated reagents along the fourth straight line 924 into the reaction vessel located at the other of the third reagent discharge position 24 or the fourth reagent discharge position 25.
[0198] The reaction disk 20 rotates to move the two target reaction vessels to the third reagent dispensing position 24 and the fourth reagent dispensing position 25, respectively, and the second reagent container storage mechanism 32 rotates to move the two target reagent containers 40 to the third reagent aspiration position 326 and the fourth reagent aspiration position 327, respectively. Then, the third reagent needle aspirates reagent from the target reagent container 40 located at either the third reagent aspiration position 326 or the fourth reagent aspiration position 327, and transfers the absorbed reagent along the third straight line 923 to inject it into the target reaction vessel located at either the third reagent dispensing position 24 or the fourth reagent dispensing position 25.
[0199] The fourth reagent needle aspirates reagent from the target reagent container 40 located at the other of the third reagent aspiration position 326 or the fourth reagent aspiration position 327, and transfers the absorbed reagent along the fourth straight line 924 to inject it into the target reaction vessel located at the other of the third reagent discharge position 24 or the fourth reagent discharge position 25.
[0200] As shown in Figure 2, in one embodiment, the second reagent container storage mechanism 32 has a single-ring structure, and a plurality of second mounting positions 321 transport the reaction vessel along the aforementioned second rotation path around the second rotation center 325.
[0201] Refer again to Figure 1. In another embodiment, the second reagent container storage mechanism 32 is a double-ring structure. The second storage inner plate 322 is configured to form a plurality of second internal mounting positions 3221 along a second internal rotation path. Each second internal mounting position 3221 can accommodate one reagent container 40.
[0202] The second storage outer panel 323 is configured to form a plurality of second external mounting positions 3231 along the second external rotation path. Each second external mounting position 3231 can accommodate one reagent container 40.
[0203] Furthermore, in a more specific embodiment, the third reagent aspiration position 326 is provided in the aforementioned second internal rotation path of the second storage inner platen 322, and the multiple second internal mounting positions 3221 move along the aforementioned second internal rotation path and sequentially pass through the third reagent aspiration position 326.
[0204] The fourth reagent aspiration position 327 is located in the aforementioned second external rotation path of the second storage outer plate 323, and the multiple second external mounting positions 3231 move along the aforementioned second external rotation path and sequentially pass through the fourth reagent aspiration position 327.
[0205] In another kind of more specific embodiment, the third reagent aspiration position 326 is located on the second external rotation path of the second storage outer plate 323, and a plurality of second external mounting positions 3231 move along the aforementioned first external rotation path and sequentially pass the third reagent aspiration position 326.
[0206] The fourth reagent aspiration position 327 is located in the aforementioned second internal rotation path of the second storage inner platen 322, and the multiple second internal mounting positions 3221 move along the aforementioned second internal rotation path and sequentially pass through the fourth reagent aspiration position 327.
[0207] In one embodiment, the second storage inner panel 322 and the second storage outer panel 323 maintain synchronous rotation.
[0208] In another embodiment, the second storage inner panel 322 is rotatable independently of the second storage outer panel 323. That is, when the second storage inner panel 322 rotates, the second storage outer panel 323 may remain stationary or rotate at the same or a different rotational speed as the second storage inner panel 322. Alternatively, when the second storage outer panel 323 rotates, the second storage inner panel 322 may remain stationary or rotate at the same or a different rotational speed as the second storage outer panel 323.
[0209] Furthermore, the independently rotatable second storage inner platen 322 can be controlled to directly move the target reagent container 40 to the third reagent aspiration position 326 or the fourth reagent aspiration position 327, which corresponds to the third reagent needle, depending on the type of reagent to be aspirated from the reagent container 40 placed at the second internal mounting position 3221.
[0210] The independently rotatable second storage outer plate 323 can control the target reagent container 40 to be directly moved to the third reagent aspiration position 326 or the fourth reagent aspiration position 327, which corresponds to the fourth reagent needle, depending on the type of reagent to be aspirated from the reagent container 40 placed at the second external mounting position 3231.
[0211] Furthermore, the reaction disk 20 has a horizontal symmetry line 800 and a vertical symmetry line 700 passing through the third rotation center 515. The horizontal symmetry line 800 and the vertical symmetry line 700 divide the reaction disk 20 into the first quadrant, the second quadrant, the third quadrant, and the fourth quadrant.
[0212] In one embodiment, the first rotation center 315 and the second rotation center 325 are located on both sides of the vertical symmetry line 700 and on the same side of the horizontal symmetry line 800. As a result, the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 are located in the aforementioned first and second quadrants outside the reaction disk 20, or in the aforementioned third and fourth quadrants outside the reaction disk 20, respectively.
[0213] In another embodiment, the first pivot center 315 and the second pivot center 325 are located on both sides of the horizontal symmetry line 800 and on the same side of the vertical symmetry line 700. As a result, the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 are located in the aforementioned first quadrant and fourth quadrant outside the reaction disk 20, or in the aforementioned second quadrant and third quadrant outside the reaction disk 20, respectively.
[0214] Specifically, the reaction disk 20, the first reagent container storage mechanism 31, and the second reagent container storage mechanism 32 are all located on the stage 10. Moreover, the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 are located on the same side of the stage 10 to facilitate the attachment and detachment of the reagent containers 40 to and from the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32.
[0215] Furthermore, the first rotational center 315 of the first reagent container storage mechanism 31 and the second rotational center 325 of the second reagent container storage mechanism 32 are connected to form a center line 200.
[0216] The foot of the vertical symmetry line 700 and the center line 200 lies at the midpoint of the center line 200.
[0217] Specifically, the straight-line distance from the first rotation center 315 to the third rotation center 515 is equal to the straight-line distance from the second rotation center 325 to the third rotation center 515. As a result, the triangle formed by the lines connecting the three points of the first rotation center 315, the second rotation center 325, and the third rotation center 515 is an isosceles triangle. Moreover, the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 are distributed symmetrically on both sides of the reaction disk 20 along the vertical symmetry line 700.
[0218] For the sake of clarity, spatial relative terms such as "above," "above," "on the top surface," and "on the top" can be used here to describe the spatial positional relationship between one element or feature shown in the drawing and another element or feature. It should be understood that spatial relative terms are intended to include different orientations of use or operation of the element other than the orientation described in the drawing. For example, if the element in the drawing is upside down, an element described as "above another element or structure" or "on top of another element or structure" would then be positioned as "below the other element or structure" or "below the other element or structure." Thus, the exemplary term "above" can include two orientations: "above" and "below." This element may also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatial relative descriptions used here should be interpreted accordingly.
[0219] Furthermore, using terms such as "first" and "second" to specify parts is merely to make it easier to distinguish the relevant parts, and unless specifically declared, these terms have no special meaning and cannot be understood as a limitation on the scope of protection of this application.
[0220] The foregoing are merely preferred embodiments of the present application and are not intended to limit it, and to those skilled in the art, the present application may be subject to various modifications and changes. Any modifications, equivalent substitutions, improvements, etc., made in the spirit and principles of the present application should be included within the scope of protection. [Explanation of Symbols]
[0221] 100: Sample analyzer 10: Stage 20: Reaction Disk 21: 4th Movement Center 22: First reagent dispensing position 23: Second reagent dispensing position 24: Third reagent dispensing position 25: Fourth reagent dispensing position 26: Reaction inner tray 261: Fourth internal mounting position 27: Reaction outer tray 271: Fourth external mounting position 31: First reagent container storage mechanism 311: First mounting position 312: 1st storage inner panel 3121: First internal mounting position 3122: First inner loading / unloading position 313: First storage outer shell 3131: First external mounting position 3132: First outer loading / unloading position 314: First insertion / removal position 315: First Movement Center 316: First reagent aspiration position 317: Second reagent aspiration position 32: Second reagent container storage mechanism 321: Second mounting position 322:Second storage inner panel 3221: Second internal mounting position 3222: Second inner loading / unloading position 323: Second storage outer panel 3231: Second external mounting position 3232: Second outer loading / unloading position 324: Second insertion / removal position 325: 2nd Movement Center 326: Third reagent aspiration position 327: Fourth reagent aspiration position 40: Reagent container 51: Temporary storage mechanism for reagent containers 511: Third mounting position 512:Temporary storage inner board 5121: Third internal mounting position 5122: Third inner loading / unloading position 513:Temporary storage outer disc 5131: Third external mounting position 5132: Third outer loading / unloading position 514: Third insertion / removal position 5141: Third left insertion / removal position 5142: Third right insertion / removal position 515: 3rd Movement Center 52: Reagent container transfer mechanism 521: Removal and reinsertion device 522: Rotary drive device 523: Lifting drive device 524: Horizontal drive unit 60: Collection Box 61: Collection port 70: Specimen transport mechanism 91: First reagent injection mechanism 911: First reagent needle 913: 1st straight line 914:Second straight line 92: Second reagent injection mechanism 923: Third straight line 924: 4th straight line 200: Center line 300: Transfer route 400: 1st included angle 500: 2nd included angle 600: 3rd included angle 700: Vertical symmetry line 800: Horizontal symmetry line
Claims
1. A specimen analysis device, A reaction disc (20) is provided on the stage (10), First reagent container storage mechanism (31), The second reagent container storage mechanism (32) and A reagent container temporary storage mechanism (51) on which a reagent container (40) is placed and located between the first reagent container storage mechanism (31) and the second reagent container storage mechanism (32), The system includes a reagent container transfer mechanism (52), The first pivot center (315) of the first reagent container storage mechanism (31) and the second pivot center (325) of the second reagent container storage mechanism (32) are connected to form a center line (200). The third rotational center (515) of the reagent container temporary storage mechanism (51) and the fourth rotational center (21) of the reaction disk (20) are located on either side of the center line (200), The reagent container transfer mechanism (52) is used to transfer reagent containers (40) between the first reagent container storage mechanism (31) and the reagent container temporary storage mechanism (51), and / or between the second reagent container storage mechanism (32) and the reagent container temporary storage mechanism (51). The transfer path (300) of the reagent container transfer mechanism (52) is parallel to the center line (200), and the number of the first insertion / removal position (314) of the first reagent container storage mechanism (31), the second insertion / removal position (324) of the second reagent container storage mechanism (32), and the third insertion / removal position (514) of the reagent container temporary storage mechanism (51) is at least one. A line of vertical symmetry (700) is formed that passes through the fourth pivot center (21) and is perpendicular to the center line (200), The third pivot center (515) is offset from the vertical symmetry line (700) and is close to the first reagent container storage mechanism (31) or the second reagent container storage mechanism (32). A sample analyzer characterized in that the vertical symmetry line (700) and the vertical foot of the center line (200) are located at the midpoint of the center line (200).
2. The first reagent container storage mechanism (31) includes a first storage inner plate (312) and a first storage outer plate (313), the first storage inner plate (312) being located inside the first storage outer plate (313), and both the first storage inner plate (312) and the first storage outer plate (313) rotating around the first pivot center (315). The first storage inner panel (312) has a first inner insertion / removal position (3122) corresponding to the transfer path (300), and the first storage outer panel (313) has a first outer insertion / removal position (3132) corresponding to the transfer path (300). The second reagent container storage mechanism (32) includes a second storage inner plate (322) and a second storage outer plate (323), the second storage inner plate (322) being located inside the second storage outer plate (323), both of which rotate around the second pivot center (325), the second storage inner plate (322) having a second inner insertion / removal position (3222) corresponding to the transfer path (300), and the second storage outer plate (323) having a second outer insertion / removal position (3232) corresponding to the transfer path (300). The reagent container temporary storage mechanism (51) includes a temporary storage inner plate (512) and a temporary storage outer plate (513), the temporary storage inner plate (512) being located inside the temporary storage outer plate (513), the temporary storage inner plate (512) having a third inner insertion / removal position (5122) corresponding to the transfer path (300), and the temporary storage outer plate (513) having a third outer insertion / removal position (5132) corresponding to the transfer path (300). The sample analyzer according to claim 1, characterized in that the reagent container transfer mechanism (52) is used to transfer a reagent container (40) between the first inner insertion / removal position (3122) or the first outer insertion / removal position (3132) and the third inner insertion / removal position (5122) or the third outer insertion / removal position (5132), and / or is used to transfer a reagent container (40) between the second inner insertion / removal position (3222) or the second outer insertion / removal position (3232) and the third inner insertion / removal position (5122) or the third outer insertion / removal position (5132).
3. The first storage inner plate (312) is configured to form a plurality of first internal mounting positions (3121) for supporting reagent containers (40) along the circumferential direction of the first pivot center (315), and the first storage inner plate (312) rotates such that the plurality of first internal mounting positions (3121) sequentially pass through the first internal loading / unloading position (3122). The first storage outer plate (313) is configured to form a plurality of first external mounting positions (3131) for supporting reagent containers (40) along the circumferential direction of the first pivot center (315), and the first storage outer plate (313) rotates such that the plurality of first external mounting positions (3131) sequentially pass through the first external loading / unloading position (3132), The second storage inner plate (322) has a plurality of second internal mounting positions (3221) formed along the circumferential direction of the second pivot center (325) for supporting reagent containers (40), and the second storage inner plate (322) rotates so that the plurality of second internal mounting positions (3221) sequentially pass through the second internal loading / unloading position (3222), The second storage outer plate (323) is configured to form a plurality of second external mounting positions (3231) for supporting a plurality of reagent containers (40) along the circumferential direction of the second pivot center (325), and the second storage outer plate (323) rotates such that the plurality of second external mounting positions (3231) sequentially pass through the second external loading / unloading position (3232), The temporary storage inner plate (512) is configured to form a plurality of third internal mounting positions (5121) for supporting reagent containers (40) along the circumferential direction of the third pivot center (515), and the temporary storage inner plate (512) rotates such that the plurality of third internal mounting positions (5121) sequentially pass through the third internal loading / unloading position (5122). The temporary storage outer plate (513) is configured to form a plurality of third external mounting positions (5131) for supporting reagent containers (40) along the circumferential direction of the third pivot center (515), and the temporary storage outer plate (513) rotates such that the plurality of third external mounting positions (5131) sequentially pass through the third external loading / unloading position (5132). The sample analyzer according to claim 2, characterized in that the reagent container transfer mechanism (52) is used to transfer a reagent container (40) between a first inner insertion / removal position (3122) or a first outer insertion / removal position (3132) and the third inner insertion / removal position (5122), or to transfer a reagent container (40) between the first inner insertion / removal position (3122) or a first outer insertion / removal position (3132) and the third outer insertion / removal position (5132), or to transfer a reagent container (40) between the second inner insertion / removal position (3222) or a second outer insertion / removal position (3232) and the third inner insertion / removal position (5122), or to transfer a reagent container (40) between the second inner insertion / removal position (3222) or a second outer insertion / removal position (3232) and the third outer insertion / removal position (5132).
4. The sample analyzer according to claim 1, characterized in that the third insertion / removal position (514) includes a third left insertion / removal position (5141) close to the first reagent container storage mechanism (31) and a third right insertion / removal position (5142) close to the second reagent container storage mechanism (32), and the reagent container transfer mechanism (52) transfers the reagent container (40) between the first insertion / removal position (314) and the third left insertion / removal position (5141), and between the second insertion / removal position (324) and the third right insertion / removal position (5142).
5. The reagent container transfer mechanism (52) is A device (521) for inserting and removing reagent containers (40), A rotary drive device (522) for driving the rotation of the aforementioned loading / unloading device (521), A lifting drive device (523) for driving the aforementioned loading / unloading device (521) to move up and down, A horizontal drive device (524) is included, The specimen analyzer according to claim 1, characterized in that the horizontal drive device (524) drives the loading / unloading device (521) to move along the transfer path (300) between the first loading / unloading position (314) and the third loading / unloading position (514), and between the second loading / unloading position (324) and the third loading / unloading position (514).
6. The sample analyzer according to claim 5, characterized in that the insertion / removal device (521) is a clip, or the insertion / removal device (521) is an adsorption nozzle, and the adsorption nozzle is provided off-center from the rotation axis of the rotary drive device (522).
7. The first reagent container storage mechanism (31) is configured to form a plurality of first mounting positions (311) for supporting the reagent container (40) along the circumferential direction of the first pivot center, and the first reagent container storage mechanism (31) rotates such that the plurality of first mounting positions (311) sequentially pass through the first loading / unloading position (314). The second reagent container storage mechanism (32) is configured to form a plurality of second mounting positions (321) for supporting the reagent container (40) along the circumferential direction of the second pivot center, and the second reagent container storage mechanism (32) rotates such that the plurality of second mounting positions (321) sequentially pass through the second loading / unloading position (324). The reagent container temporary storage mechanism (51) is configured to form a plurality of third mounting positions (511) for supporting the reagent container (40) along the circumferential direction of the third pivot center, and the reagent container temporary storage mechanism (51) rotates so that the plurality of third mounting positions (511) sequentially pass through the third loading / unloading position (514). The sample analyzer according to claim 1, characterized in that the reagent container transfer mechanism (52) is used to transfer the reagent container (40) between a first insertion / removal position (314) and a third insertion / removal position (514), or between a second insertion / removal position (324) and a third insertion / removal position (514).
8. A horizontal symmetry line (800) is formed that passes through the fourth pivot center (21) and is parallel to the center line (200). The aforementioned sample analyzer further comprises a sample transport mechanism (70) for transporting sample containers, The specimen analyzer according to claim 1, characterized in that the center line (200) and the specimen transport mechanism (70) are located on opposite sides of the horizontal symmetry line (800), respectively.
9. The specimen analyzer according to any one of claims 1 to 8, further comprising a collection box (60), wherein the collection port (61) of the collection box (60) is provided below the transfer path (300).
10. The sample analyzer according to claim 9, characterized in that the recovery port (61) is located between the first reagent container storage mechanism (31) and the reagent container temporary storage mechanism (51), or the recovery port (61) is located between the second reagent container storage mechanism (32) and the reagent container temporary storage mechanism (51).
11. The reaction disk (20) can support a plurality of reaction vessels and includes a first reagent dispensing position (22), a second reagent dispensing position (23), a third reagent dispensing position (24), and a fourth reagent dispensing position (25). The first reagent container storage mechanism (31) includes a first reagent aspiration position (316) and a second reagent aspiration position (317), The second reagent container storage mechanism (32) includes a third reagent aspiration position (326) and a fourth reagent aspiration position (327), The sample analyzer further includes a first reagent injection mechanism (91) and a second reagent injection mechanism (92), The first reagent injection mechanism (91) includes a first reagent needle (911) and a second reagent needle that operate independently. The first reagent needle (911) is used to aspirate a reagent from the reagent container (40) at the first reagent aspiration position (316) and to transfer and inject it along the first straight line (913) into the reaction vessel located at the first reagent discharge position (22). The second reagent needle is used to aspirate a reagent from the reagent container (40) at the second reagent aspiration position (317) and to transfer and inject it along the second straight line (914) into the reaction vessel located at the second reagent discharge position (23). The second reagent injection mechanism (92) includes a third reagent needle and a fourth reagent needle that operate independently. The third reagent needle is used to aspirate a reagent from the reagent container (40) at the third reagent aspiration position (326) and to transfer and inject it along the third straight line (923) into the reaction vessel located at the third reagent discharge position (24). The specimen analyzer according to any one of claims 1 to 8, characterized in that the fourth reagent needle is used to aspirate a reagent from a reagent container (40) located at the fourth reagent aspiration position (327) and to transfer and inject it along the fourth straight line (924) into a reaction vessel located at the fourth reagent discharge position (25).
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