Oral care compositions, uses, and oral care products

Abstract

This invention provides oral care compositions, uses, and oral care products. [Solution] The oral care composition comprises a) 3-hydroxybutyric acid and b) tetrasodium pyrophosphate, wherein the mass ratio of 3-hydroxybutyric acid to tetrasodium pyrophosphate is 0.001 to 1:1. This application discloses an oral care composition in which, by combining D-3-hydroxybutyric acid and tetrasodium pyrophosphate, it is possible to enable 3-hydroxybutyric acid and tetrasodium pyrophosphate to exhibit excellent teeth whitening effectiveness even at relatively low concentrations, effectively reducing the amount of tetrasodium pyrophosphate used and avoiding dental health problems such as tooth demineralization caused by long-term use of high concentrations of tetrasodium pyrophosphate.

Description

Technical Field

[0001] This application relates to the field of oral care technology, specifically to oral care compositions, uses, and oral care products.

Background Art

[0002] As the interest in oral health and aesthetics increases, the market demand for tooth whitening products continues to grow. Tooth discoloration is mainly caused by two factors: exogenous pigment deposition and endogenous pigment formation. Exogenous pigments mainly come from food, beverages, and tobacco, while endogenous pigments are caused by factors such as tetracycline drugs and excessive fluoride intake. Currently, common commercially available whitening toothpastes mainly achieve the whitening effect through physical polishing and chemical removal.

[0003] ​​​​​​​​​​​​One of the objectives of this application is to provide an oral care composition that enhances the whitening effect through the synergistic effect between its components at low concentrations.

[0006] Another object of this application is to provide uses for oral care compositions.

[0007] Furthermore, this application provides an oral care product, which contains the oral care composition described in this application and combines a high whitening effect with a protective effect on tooth health.

[0008] To achieve the above objective, this application provides an oral care composition. This oral care composition comprises a) D-3-hydroxybutyric acid and b) tetrasodium pyrophosphate, wherein the mass ratio of 3-hydroxybutyric acid to tetrasodium pyrophosphate is 0.001 to 1:1.

[0009] Furthermore, the mass ratio of D-3-hydroxybutyric acid to tetrasodium pyrophosphate is 0.05 to 0.8:1.

[0010] This application also provides applications for manufacturing oral care products using the above-described oral care composition.

[0011] This application further provides an oral care product containing 0.5 to 2 wt% of the above oral care composition.

[0012] The oral care products described in this application include oral care products that can care for teeth, such as toothpaste, mouthwash, and oral spray. Preferably, the oral care product is any one of toothpaste, mouthwash, or oral spray. [Effects of the Invention]

[0013] Compared to conventional technologies, this application discloses an oral care composition that, by combining 3-hydroxybutyric acid and tetrasodium pyrophosphate, enables excellent teeth whitening effectiveness even at relatively low concentrations, effectively reducing the amount of tetrasodium pyrophosphate used and avoiding dental health problems such as the risk of tooth demineralization caused by long-term use of high concentrations of tetrasodium pyrophosphate. [Modes for carrying out the invention]

[0014] The present application will be further described below with reference to examples, but these examples will not limit the present application. Limited modifications made within the scope of the claims of this application will still be included within the scope of the claims of this application.

[0015] In order to explain the technical content of this application in detail, the following description will be given in conjunction with the embodiments.

[0016] In the following examples and comparative examples, the CAS number of D-3-hydroxybutyric acid is 625-72-9, the CAS number of tetrasodium pyrophosphate is 7722-88-5, the CAS number of sodium phytate is 14306-25-3, the CAS number of pentasodium tripolyphosphate is 7758-29-4, and the CAS number of sodium hexametaphosphate is 68915-31-1.

[0017] Furthermore, the technical solution described in this application can be implemented using commercially available products, and the above-mentioned CAS number is used to confirm its molecular structure so that those skilled in the art can implement it.

[0018] In the following examples and comparative examples, unless otherwise specified, parts refer to parts by weight, and % refers to percentage by weight.

[0019] The compositions were prepared according to the formulation table in Table 1. The preparation method involved stirring at 55±5℃ and 1000 rpm until homogeneous.

[0020] JPEG0007905011000001.jpg 106170 Whitening Effectiveness Test

[0021] Test Method Evaluation Method for the Removal Effect on Extrinsic Tooth Stains: The compositions of Examples 1 - 6 and Comparative Examples 1 - 8 were each prepared as 1% aqueous solutions and used in the stain removal test.

[0022] Referring to the experimental method in 《T / COCIA 26 - 2024 Evaluation of the Effectiveness of Oral Care Products, In Vitro Effectiveness Evaluation on the Prevention and Decomposition of Extrinsic Tooth Stains》, HAP pieces were immersed in a black tea solution for 3 minutes, taken out, rinsed with deionized water to remove the residual liquid, and dried with a paper towel. The color tone Lab values of the HAP pieces were measured and recorded using a colorimeter. Then, the HAP pieces were each placed in the aqueous solution of each test composition and immersed for 2 minutes, taken out, repeatedly rinsed, and dried. After that, the Lab values were measured again. The difference in the color tone L values after HAP staining and after decolorization was compared. ΔL value = L value after decolorization - L value after staining. The larger the ΔL value, the stronger the ability to remove extrinsic tooth stains, indicating a higher stain removal effect.

[0023] Examples 1 - 6 and Comparative Examples 1 - 8 were tested according to the above method, and the results are shown in Table 2.

[0024] JPEG0007905011000002.jpg 135170

[0025] The following was found from the results in Table 2. As can be seen from the data of Comparative Examples 1 - 5, in the tooth whitening effect part, at a 1% concentration, sodium tetrapyrophosphate > sodium hexametaphosphate > sodium tripolyphosphate > sodium phytate > D - 3 - hydroxybutyric acid.

[0026] However, as can be seen from Examples 1 to 6 of the present application, when using a combination of tetrasodium pyrophosphate and D-3-hydroxybutyric acid, the stain removal effect of the composition can be significantly improved, and it can be inferred that the combination of tetrasodium pyrophosphate and D-3-hydroxybutyric acid has an effect of synergistically improving the tooth whitening effectiveness of the composition. Generally, it is inferred that the higher the concentration of D-3-hydroxybutyric acid in the composition, the more significant the synergistic effect, and the higher the ΔL value of the stain removal effect. However, in the technical solution of Example 2, an exception occurred when the blending ratio of D-3-hydroxybutyric acid and tetrasodium pyrophosphate was 0.3:1. Its stain removal effect was weaker than that of Example 3 and Example 4 containing a lower concentration of D-3-hydroxybutyric acid, and even had the same effect as Example 5. This indicates that the technical solution of the present application suggests that D-3-hydroxybutyric acid and tetrasodium pyrophosphate can exhibit a more excellent synergistic effect at a specific blending ratio.

[0027] Considering the results of Example 4 and Comparative Examples 6 to 8 in combination with the data of Comparative Examples 1 to 6, it can be inferred that D-3-hydroxybutyric acid only exhibits a synergistic effect of enhancing the tooth whitening effectiveness of the composition when combined with tetrasodium pyrophosphate, and similarly, other components having the ability to chelate calcium ions do not exhibit a synergistic effect with D-3-hydroxybutyric acid.

[0028] Based on the synergistic effect of the combination of D-3-hydroxybutyric acid and tetrasodium pyrophosphate, the applicant of the present application infers the mechanism of its whitening and tooth health protection as follows. 3-Hydroxybutyric acid, due to the properties of its hydroxyl and carboxyl groups to form five-membered cyclic chelate compounds with colored metal ions, can selectively capture stain molecules on teeth and remove colored ions from the tooth surface, achieving highly accurate stain removal without affecting the normal mineralization process of teeth or their caries-preventive ability. Based on this, because 3-hydroxybutyric acid is weakly acidic and lipophilic, it can penetrate the stain-enamel interface and break down color-developing polymers. Tetrasodium pyrophosphate is Ca 2+ / Fe 3+ It has a chelating effect, preventing remineralization of the stain matrix and suppressing tartar formation. The two work synergistically to improve whitening and stain removal effects. This synergistic effect makes it possible to reduce the concentration of tetrasodium pyrophosphate used, and because 3-hydroxybutyrate has a relatively weak ability to chelate calcium ions, it is possible to achieve the effect of not risking tooth demineralization even with long-term use.

[0029] The embodiments presented herein are merely selected examples based on all possible combinations of embodiments. The appended claims should not be limited to the embodiments described herein. Some numerical ranges used in the claims include subranges within those ranges, and variations within these ranges should also be covered by the appended claims.

Claims

1. A composition for removing extrinsic stains from teeth, comprising D-3-hydroxybutyric acid and tetrasodium pyrophosphate, wherein the mass ratio of D-3-hydroxybutyric acid to tetrasodium pyrophosphate is 0.001 to 1:

1.

2. The tooth extrinsic stain removal composition according to claim 1, characterized in that the mass ratio of D-3-hydroxybutyric acid to tetrasodium pyrophosphate is 0.05 to 0.8:

1.

3. A method for producing an oral care product using the tooth extrinsic stain removal composition described in claim 1 or 2.

4. An oral care product containing 0.5 to 2 wt% of the tooth extrinsic stain removal composition according to claim 1 or 2.

5. The oral care product according to claim 4, characterized in that it includes one of toothpaste, mouthwash, or oral spray.

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