Hair growth composition

Abstract

To provide a composition for hair growth that excels in efficacy and quality stability, as well as biological safety, vitalizes dermal papilla cells that control a hair cycle, and exhibits the effect of normalizing the hair cycle.SOLUTION: A composition for hair growth comprises extract from Torulaspora yeast as an active ingredient.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an active ingredient that can be formulated in a hair growth composition having excellent biocompatibility and a hair papilla cell activating effect.

Background Art

[0002] In recent years, due to various factors such as aging, stress, or ultraviolet rays, the scalp is damaged, and the number of people, including both men and women, who have hair problems is increasing. In response, various hair cosmetics have been proposed. Conventionally, research has been conducted on male pattern hair loss (androgenetic alopecia in middle-aged men) and female pattern hair loss (androgenetic alopecia occurring in women), and it has been clarified that male hormones are involved in these hair loss conditions. Various anti-androgen agents have been proposed as agents for improving hair problems.

[0003] In order to prevent the aging and deterioration of the scalp as described above and maintain a youthful state, and further, based on the research on the mechanisms of the above-mentioned scalp damage and hair loss, various hair growth and hair nourishing agents, hair loss inhibitors (referred to as hair growth agents, etc.) have been proposed. As active ingredients that exhibit the effects of hair growth and hair nourishing, for example, minoxidil and adenosine are known, and hair growth agents containing these ingredients have been proposed. However, there is a further demand for hair growth ingredients derived from natural products.

Disclosure of the Invention

Problems to be Solved by the Invention

[0004] In view of the problems of such prior art, the present inventors have conducted intensive research to find a new active ingredient derived from natural products. As a result, it has been newly found that an extract, dried product, or concentrate of yeast belonging to the genus Torulaspora has a hair papilla cell activating effect and is useful as a component of a hair growth composition.

[0005] While it was previously known from Patent Documents 1 and 2 that Torluspora yeast or its cultures may have potential uses in food and topical skin preparations, it was not known that yeast extracts have a hair papilla cell-activating effect and are useful as components of hair growth compositions. [Patent Document 1] Japanese Patent Publication No. 06-078754 [Patent Document 2] Japanese Patent Publication No. 2009-029788 [Means for solving the problem]

[0006] The present invention relates to a hair growth composition containing an extract of Torulaspora yeast, or a dried or concentrated thereof, as an active ingredient. [Effects of the Invention]

[0007] According to the present invention, it is possible to provide a hair growth composition that is highly biocompatible and has an excellent effect in activating hair papilla cells. [Modes for carrying out the invention]

[0008] Preferred embodiments of the present invention will be described in detail below. In addition, examples of yeasts of the genus Torulaspora in the present invention include Torulaspora delbruekii (synonym: Saccharomyces delbruekii), Torulaspora globosa, Torulaspora franciscae, and Torulaspora pretoriensis.

[0009] There are no particular limitations on the carbon source used when culturing yeast. Examples of carbon sources include glucose, fructose, lactose, raffinose, and xylose. In addition to the carbon source, a nitrogen source may also be added. Examples of nitrogen sources include amino acids and peptones.

[0010] The culture temperature for yeast is in the range of 20°C to 50°C, preferably 25°C to 40°C. The pH is in the range of 3.0 to 8.0, preferably 4.0 to 7.0.

[0011] Yeast extracts can be prepared by filtering yeast culture solution. Alternatively, yeast extracts may be prepared by filtering yeast processed products obtained by hydrolysis, which solubilizes cellular components of cultured yeast with acid or alkali; autolysis, which utilizes proteolytic enzymes within the yeast cells (for example, culture at 40°C to 55°C); enzymatic methods, which utilize enzyme preparations such as proteolytic enzymes; or a combination of these methods.

[0012] Yeast extract concentrates can be obtained by concentrating a yeast culture medium, or a liquid obtained by hydrolysis, autolysis of yeast, or enzymatic methods, using a vacuum concentrator or the like.

[0013] Furthermore, dried yeast extracts can be obtained by drying the yeast culture solution or its concentrate using methods such as vacuum drying or spray drying.

[0014] Furthermore, the dried yeast extract may be prepared as a dried product to which excipients have been added for the purpose of improving chemical stability and low hygroscopicity. Excipients can include sugars such as starch, glucose, crystalline cellulose, lactose, and dextrin, as well as sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, maltitol, and lactitol. Any substance that can be mixed with the yeast extract and dried into a powder is acceptable.

[0015] The amount of yeast extract or its concentrate or dried product used in the present invention is in the range of 0.002 to 20.0% by weight in the case of a cleansing hair cosmetic, as a solid content. In the case of a hair growth composition, it is in the range of 0.0001 to 10.0% by weight in terms of solid content.

[0016] Furthermore, it is suggested that a synergistic effect on hair growth can be obtained by using the yeast extract or its dried or concentrated product according to the present invention in combination with other hair growth ingredients. For example, ingredients that can be expected to have a synergistic effect on hair growth and hair nourishment include minoxidil, cyproterone acetate, pentadecanoate glyceride, 6-aminobenzylpurine (cytoprin), adenosine, trans-3,4'-dimethyl3-hydroxyflavanone (t-flavanone), Swertia japonica extract, Sophora flavescens extract, hinokitiol, photosensitizer, pantothenic acid and its derivatives, vitamin E and its derivatives, nicotinic acid derivatives (nicotinamide, etc.), carpronium chloride, female hormones (ethinylestradiol, estrone, etc.), salicylic acid, dipotassium glycyrrhizate, hinokitiol, benzalkonium chloride, and isopropyl alcohol. Examples of ingredients include methylphenol, l-menthol, pyridoxine hydrochloride (vitamin B6), thioxolone, camphor, resorcinol, Stephania tetrandra root extract, bis-type alkaloids obtained from Stephania tetrandra, licorice extract, Scutellaria baicalensis flower extract, chamomile extract, royal jelly ferment, lotus seed ferment, ginkgo extract, Par d'arco bark extract, gentian extract, ginseng extract, soy milk ferment, glasswort extract, bamboo shoot peel extract, kudzu root extract, burdock extract, kelp extract, clove extract, collagen, amino acids, and vitamins, and one or more of these may be included.

[0017] Furthermore, in addition to the above-mentioned components, hair growth compositions (including quasi-drugs and pharmaceuticals) containing yeast extracts or their dried or concentrated products may appropriately incorporate, as needed, other components commonly used in hair growth and hair nourishment products and hair growth agents (including quasi-drugs), such as oily components, surfactants (synthetic and natural), humectants, thickeners, emulsifiers or emulsifying aids, preservatives and bactericides, powder components, UV absorbers, antioxidants, pigments, fragrances, and other physiologically active components. There is also no problem in combining them with other physiologically active components derived from natural products in compositions for topical application to the skin.

[0018] Oily components include, for example, plant-derived oils and fats such as olive oil, jojoba oil, castor oil, soybean oil, rice bran oil, rice germ oil, coconut oil, palm oil, cocoa oil, meadowfoam oil, shea butter, tea tree oil, avocado oil, macadamia nut oil, bergamot oil, lavender oil, rose oil, chamomile oil, etc.; vitamin A oil; animal-derived oils and fats such as mink oil and turtle oil; waxes such as beeswax, carnauba wax, rice wax, and lanolin; liquid paraffin, petrolatum, and paraffin wax. Examples include hydrocarbons such as squalane; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, and cis-11-eicosenoic acid; higher alcohols such as lauryl alcohol, cetanol, pantothenyl alcohol, and stearyl alcohol; synthetic esters and synthetic triglycerides such as isopropyl myristate, isopropyl palmitate, butyl oleate, 2-ethylhexylglyceride, and higher fatty acid octyldodecyl (octyldodecyl stearate, etc.).

[0019] Examples of surfactants include nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkylphenyl ether sulfates, polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, and polyoxyethylene Anionic surfactants such as ethylene alkylphenyl ether phosphates; cationic surfactants such as quaternary ammonium salts, primary to tertiary fatty amine salts, trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N,N-dialkylmorphonium salts, polyethylene polyamine fatty acid amide salts; and amphoteric surfactants such as N,N-dimethyl-N-alkyl-N-carboxymethylammonium betaine, N,N,N-trialkyl-N-alkyleneammonium carboxybetaine, and N-acylamidopropyl-N′,N′-dimethyl-N′-β-hydroxypropylammonium sulfobetaine can be used.

[0020] As emulsifiers and / or emulsifying aids, stevia derivatives such as enzyme-treated stevia, saponins or their derivatives, casein or its salts (sodium, etc.), sugar-protein complexes, sucrose or its esters, lactose, water-soluble polysaccharides derived from soybeans, complexes of soybean-derived proteins and polysaccharides, lanolin or its derivatives, cholesterol, stevia derivatives (such as enzyme-treated stevia), silicates (aluminum, magnesium, etc.), carbonates (calcium, sodium, etc.), saponins and their derivatives, lecithin and its derivatives (such as hydrogenated lecithin), lactic acid bacteria-fermented rice, lactic acid bacteria-fermented germinated rice, lactic acid bacteria-fermented grains (wheat, beans, grains, etc.), etc. may also be included.

[0021] Examples of the humectant include glycerin, propylene glycol, dipropylene glycol, 1,3 - butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, etc. Further, saccharides such as trehalose and raffinose, mucopolysaccharides (for example, hyaluronic acid and its derivatives, hyaluronic acid fermentation broth, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, collagen peptides, NMF - related substances, lactic acid, urea, octyldodecyl higher fatty acid, seaweed extract, estradiol, various amino acids and their derivatives can be mentioned.

[0022] Examples of the thickener include components derived from brown algae, green algae or red algae such as alginic acid, agar, carrageenan, fucoidan, etc.; polysaccharides such as pectin, aloe polysaccharide, etc.; gums such as tragacanth gum, locust bean gum, xanthan gum, guar gum, etc.; cellulose derivatives such as carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, etc.; synthetic polymers such as carboxyvinyl polymer, alkyl - modified carboxyvinyl polymer, polyvinyl alcohol, polyvinyl pyrrolidone, acrylic acid - methacrylic acid copolymer, etc.; hyaluronic acid and its derivatives; polyglutamic acid and its derivatives, polyacrylic acid, etc.

[0023] Examples of the anti - inflammatory agent include allantoin, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β - glycyrrhetinic acid, stearyl glycyrrhetinate, ε - aminocaproic acid, d - camphor, dl - camphor, zinc oxide, panthenol, pyridoxine hydrochloride, nicotinamide and riboflavin or its derivatives, etc.

[0024] Examples of antiseptics and bactericides include urea; benzoic acid or its salts, paraoxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, etc.; phenoxyethanol, dichlorophen, hexachlorophene, chlorhexidine hydrochloride, benzalkonium chloride, salicylic acid, sodium salicylate, zinc pyrithione, benzalkonium chloride, ethanol, undecylenic acid, phenols, alkylisquinolinium bromide, resorcin, jamerl (imidazodine urea), isopropylmethylphenol, triclosan, trichlorocarbanide, trichlorohydroxydiphenyl ether, hinokitiol, 1,2-pentanediol, propanediol, concentrated benzalkonium chloride solution 50, essential oils such as peppermint oil, eucalyptus oil, etc., bark distillates, radish fermentation broth, ethanol derived from plants such as sugarcane, corn, etc., or 1,3-butylene glycol, etc.

[0025] Examples of cell activators include pantothenyl alcohol, menthol, dl-menthol, and γ-oryzanol, etc.

[0026] Examples of anti-acne agents include sulfur, salicylic acid or its salts, photosensitizer No. 201, pyridoxine dicaprylate, etc.

[0027] Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, anhydrous silicic acid, mica, nylon powder, polyethylene powder, silk powder, cellulose-based powder, powders of cereals (rice, wheat, corn, millet, etc.), powders of beans (soybean, adzuki bean, etc.), etc.

[0028] Examples of UV absorbers include ethyl para-aminobenzoate, ethylhexyl para-dimethylaminobenzoate, amyl salicylate and its derivatives, 2-ethylhexyl para-methoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-tert-butyl-4-methoxybenzoylmethane, 2-(2-hydroxy-5-methylphenyl)benzotriazole, urocanic acid, ethyl urocanate, and aloe extract.

[0029] Examples of antioxidants include carotenoids such as butylhydroxyanisole, butylhydroxytoluene, propyl gallate, and astaxanthin, vitamin E and its derivatives (e.g., tocopherol acetate, tocopherol nicotinate), and vitamin A or its derivatives (e.g., retinol palmitate).

[0030] Furthermore, the following natural ingredients derived from plants or microorganisms can also be used in combination: for example, collagen or its hydrolysates, yeast extract or hydrolysates, lactic acid bacteria cultures, grasses, cruciferous plants, camellias, roses, peonyes, citrus plants, amaranthaceae plants, eelgrasses, legumes, daisies, legumes, mallows, gentians, mints, lotus, cucurbits, Araliaceae plants, nightshades, bignoniaceae plants, Actinidiaceae plants, mulberries, irises, bellflowers, olives, Actinidiaceae plants, mulberries, rhamnoides, orchids, and sumac. Examples include extracts or hydrolyzed or fermented products thereof from one or more plants selected from the families of plants, Garcinia, Valenciaceae, Rutaceae, Myrtaceae, Liliaceae, Crassulaceae, Cupressaceae, Convolvulaceae, and Asparagaceae; extracts or hydrolyzed or fermented products thereof from one or more seaweeds selected from the families of Laminariaceae, Mylinaceae, and Ulvaceae; jellyfish (autolyzed products of moon jellyfish, Echizen jellyfish, etc.); hydrolyzed or fermented products of hyaluronic acid; and extracts or hydrolyzed or fermented products thereof from royal jelly.

[0031] As plant-derived components from the grass family, rice leaf hydrolysate, rice extract hydrolysate, rice bran extract hydrolysate, germinated brown rice hydrolysate, rice ferment filtrate, sake lees extract derived from sake, bamboo shoot peel extract of Madake or Moso bamboo, and adlay seed ferment. As plant-derived components from the Brassicaceae family, extracts or hydrolysates or fermentations thereof of the seeds of Hakugai, Ougai, or Kokugai are particularly preferred. As plant-derived components from the Camellia family, green tea (Yabukita, Samidori, Asahi, Gokou, Ujimidori, Kyomidori, Ujihikari, Samidori, Benifuki, etc.) and black tea (Darjeeling, Assam, Ceylon, Earl Grey, Honey Black Tea, etc.) are particularly preferred. As plant-derived components from the Rosaceae family, extracts of Damask rose flowers, peach flowers, leaves, or immature fruits, strawberry flower extract, and cherry blossom or leaf extract are preferred. Furthermore, as components derived from Paeoniaceae plants, extracts of peony root or flower, or peony flower are preferred. Furthermore, as components derived from Amaranthaceae plants, glasswort extract is particularly preferred. Furthermore, as components derived from Zosteraceae plants, extracts of Zostera margaritacea or Zostera japonica are particularly preferred. As components derived from Fabaceae plants, extracts of white soybeans or black soybeans or their hydrolysates or fermented soy milk liquid, adzuki bean extract, red clover extract, and kudzu root extract are particularly preferred. Furthermore, as components derived from Asteraceae plants, extracts of burdock root, sunflower sprout extract, starflower extract, arnica extract, or chamomile flower extract are particularly preferred. As components derived from Malvaceae plants, fermented products of hibiscus, rose of Sharon, or hibiscus are preferred. As components derived from Gentianaceae plants, gentian extract is preferred. Furthermore, as components derived from Lamiaceae plants, extracts of green perilla and Callicarpa japonica fruit are preferred. As for ingredients derived from Nelumbonaceae plants, lotus flower or lotus seed extract or lotus seed ferment is particularly preferred. As for ingredients derived from Cucurbitaceae plants, loofah extract is particularly preferred. As for ingredients derived from Araliaceae plants, ginseng extract or ferment is preferred. As for ingredients derived from Solanaceae plants, eggplant (long eggplant, water eggplant, American eggplant, Kamo eggplant, etc.) extract is an example. As for ingredients derived from Bignoniaceae plants, Pau d'arco bark extract is preferred. As for ingredients derived from Actinidiaceae plants, immature kiwi extract is preferred.Preferred ingredients from the Moraceae family include mulberry bark extract, mulberry fruit extract, and fig fruit or bark extract. Preferred ingredients from the Rhamnaceae family include jujube fruit extract. Preferred ingredients from the Iridaceae family include saffron. Preferred ingredients from the Campanulaceae family include root extract or hydrolysate of Codonopsis lanceolata. Preferred ingredients from the Anacardiaceae family include mango fruit extract. Preferred ingredients from the Garciniaaceae family include mangosteen fruit extract. Preferred ingredients from the Valenciaceae family include cherimoya fruit extract. Preferred ingredients from the Rutaceae family include Satsuma mandarin, bergamot fruit extract, grapefruit or pomelo fruit (including immature fruit), extracts containing flavonoids and their glycosides found in plants such as grapefruit or hassaku, or sansho seed extract. As ingredients derived from lily-family plants, extracts of Hemerocallis middendorffii, Hemerocallis fulva, Casablanca lily, Madonna lily, or Lilium japonicum are preferred. As ingredients derived from crasliaceae plants, extracts or fermented products of Rhodiola rosea are particularly preferred. As ingredients derived from olive-family plants, extracts of jasmine flowers are particularly preferred. As ingredients derived from cypress-family plants, extracts of Juniperus chinensis fruit are particularly preferred. As ingredients derived from myrtaceae plants, extracts of guava leaf are particularly preferred. As ingredients derived from orchids, extracts of Bletilla striata root are particularly preferred. As ingredients derived from morning glory-family plants, extracts or fermented products thereof of sweet potato, or extracts or fermented products thereof of sweet potato shochu lees are preferred. As ingredients derived from lamibariaceae seaweed, extracts of kelp are particularly preferred, as ingredients derived from miltiorrhiza, extracts of Sargassum fuciformis are preferred, and as ingredients derived from Ulvaceae seaweed, extracts of Ulva lactuca are particularly preferred. As for components derived from seaweed of the family *Sargassum*, *Sargassum* extract is particularly preferred.

[0032] Next, the present invention will be described in more detail with reference to manufacturing examples, formulation examples, and test examples, but the present invention is not limited thereto. In the following, all parts refer to parts by weight, and all percentages refer to weight percent.

[0033] Manufacturing Example 1. Preparation of Yeast Extract (1) 40 g of pre-cultured Torulaspora delbrueckii was added to 2000 g of sterile XP liquid medium, and the culture was incubated at 25°C for 3 days with stirring, after which it was heat-sterilized. The resulting sterilized culture solution was filtered to obtain 1923 g of yeast culture solution (solid content concentration 1.27%).

[0034] Test Example 1: Test of hair papilla cell activation effect Human dermal papilla cells (HFDPCs) were placed in a 96-well microplate containing TMTPGM-250 medium, 1 × 10⁶ cells per well. 4 Cells were seeded per well and pre-cultured for 1 day under conditions of 37°C and 5.0% CO2. Then, the extract from Production Example 1 was added to the culture medium as a sample solution, and cultured for a further 3 days under the same conditions. Here, the extract from Production Example 1 was added to the culture medium so that the final concentration as a solution was 2.0% of the total volume of medium. Next, the medium was removed, 0.03% MTT was added, and the culture was held at 37°C for 1 hour. The resulting formazan was extracted with isopropanol, and the MTT value was measured at a wavelength of 570-630 nm using a microplate reader (Model 680, Bio-Rad). As a control, the same procedure was performed on a control case in which the same concentration of PBS(-) was added instead of the sample solution. The relative value of the MTT value with each sample added to the MTT value obtained here was calculated and expressed as the dermal papilla cell MTT activity rate (%).

[0035] The results of Test Example 1 are shown in Table 1. [Table 1] JPEG0007909266000001.jpg46136

[0036] As shown in Table 1, the extract from Production Example 1 was confirmed to exhibit a hair papilla cell activating effect, suggesting that it revitalizes hair papilla cells, which regulate the hair cycle in vivo, and normalizes the hair cycle.

[0037] Test Example 2. Evaluation Test of Hair Growth Factor Synthesis Effect Human dermal papilla cells (HFDPCs) were placed in a 96-well microplate containing TMTPGM-250 medium, 1 × 10⁶ cells per well.4 Seeds were seeded in individual holes and pre-cultured for 1 day under conditions of 37°C and 5.0% CO2. Then, the sample-containing medium was added and cultured for a further 2 days under the same conditions. The culture supernatant was collected, and the amount of hair growth-related factors in the supernatant was evaluated by chemiluminescence measurement according to the Human Growth Factor Antibody Array (abcam ab134002) protocol. As a control, the same procedure was performed on a sample-free sample (control) in which the same concentration of PBS(-) was added instead of the sample solution. The relative values ​​obtained for each spot were calculated with the chemiluminescence value set to 100, and these were expressed as the relative secretion amount (%) of each hair growth factor.

[0038] The results of Test Example 2 are shown in Table 2. [Table 2] JPEG0007909266000002.jpg6586

[0039] As shown in Table 2, the extract according to the present invention was confirmed to promote the synthesis of hair growth factors, including fibroblast growth factor-7 (FGF-7), insulin-like growth factor-1 (IGF-1), stem cell growth factor (SCF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF). Since FGF-7, IGF-1, SCF, and VEGF are factors that transition the hair cycle into the growth phase, the extract according to the present invention is suggested to have a hair growth effect by promoting these factors. Furthermore, since PDGF is a factor that activates hair stem cells and promotes hair growth, the extract according to the present invention is suggested to contribute to promoting hair growth.

[0040] Prescription example 1. Hair growth tonic [Ingredients] Part Adenosine 1.0 Extract from Production Example 1: 1.0 1,3-Butylene glycol 10.0 Phenoxyethanol 3.0 Ethanol 20.0 Purified water, in an amount that makes the total volume 100 parts. The above ingredients were thoroughly stirred and mixed to obtain a hair growth composition.

[0041] Prescription example 2. Hair growth tonic A hair growth product was obtained in the same manner as in Prescription Example 1, except that minoxidil was used instead of adenosine in the ingredients of Prescription Example 1.

[0042] Prescription example 3. Hair growth tonic A hair growth agent was obtained in the same manner as in Prescription Example 1, except that 6-benzylaminopurine was used instead of adenosine in the ingredients of Prescription Example 1.

[0043] Prescription example 4. Hair growth tonic [Ingredients] Part l-menthol 0.8 Dipotassium glycyrrhizinate 0.1 Isopropylmethylphenol 0.1 Extract from Production Example 1 2.0 Soy lecithin 0.2 1,3-Butylene glycol 2.0 1,2-Pentanediol 3.0 Ethanol 10.0 Tamasaki Tsuzura extract 0.01 Carrot extract 0.1 Bamboo shoot peel extract 3.0 Brown algae extract 3.0 Royal jelly fermented extract 3.0 Burdock extract 3.0 Pueraria root extract 3.0 Purified water, in an amount that makes the total volume 100 parts.

[0044] Prescription Example 5: Hair Growth Cream [Ingredients] Part Liquid paraffin 15.0 Vaseline 15.0 Bleached beeswax 2.0 Dipotassium glycyrrhizinate 0.1 Extract from Production Example 1: 1.0 Swertia japonica extract 0.3 Tamasaki Tsuzura extract 0.01 Brown algae extract 0.3 Carboxyvinyl polymer 0.1 Xanthan gum 0.1 Glycerin 5.0 1,3-Butylene glycol 2.0 Polyoxyethylene hydrogenated castor oil 3.0 Hydrogenated lecithin 1.0 Lactic acid fermented rice 2.0 Chelating agent 0.1 Preservative 0.1 Fragrance 0.1 Dye 0.01 Purified water, in an amount that makes the total volume 100 parts.

[0045] Prescription Example 6: Hair Growth Shampoo [Ingredients] Part N-Coconut oil fatty acid methyl taurate sodium 10.0 Sodium polyoxyethylene(3) alkyl ether sulfate 20.0 Lauryldimethylaminoacetic acid betaine 10.0 Coconut oil fatty acid diethanolamide 4.0 Methylparaben 0.1 Citric acid 0.1 Extract from Production Example 1 2.0 Dipotassium glycyrrhizinate 0.1 Nicotinamide 1.0 Collagen 1.0 Seagrass extract 5.0 Salicornia extract 5.0 Pueraria root extract 5.0 Burdock extract 5.0 1,3-Butylene glycol 2.0 1,2-Hexanediol 1.0 Purified water, in an amount that makes the total volume 100 parts.

[0046] Example 7. Hair rinse [A component] part Polyoxyethylene (10) hydrogenated castor oil 1.0 Distearyldimethylammonium chloride 1.5 Stearyltrimethylammonium chloride 2.0 Glyceryl 2-ethylhexanoate 1.0 Cetanol 3.0 Stearyl alcohol 1.0 Methylparaben 0.1 Extract from Production Example 1 2.0 Burdock extract 1.0 Pueraria lobata extract 1.0 1,3-Butylene glycol 3.0 1,2-Pentanediol 1.0 Purified water, in an amount that makes the total volume 100 parts.

Claims

[Claim 1] A hair growth composition containing an extract of Torulaspora yeast as an active ingredient.

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