Genetic testing method and genetic testing apparatus

Abstract

A genetic testing device 1 further comprises a calculation unit 2d that adds, to the time at which an analyte is put, an available standby time depending on the priority of the analyte and calculates a target time by which dispensation to the analyte is to be completed. A control unit 2c executes dispensation of analytes in the order of target time. Consequently, in the genetic testing method and genetic testing device provided by the present invention, priority is given to measurement of an analyte with high priority, and measurement of an analyte with low priority is prevented from being overly delayed when analytes with high priority are introduced in succession.

Description

Technical Field

[0001] The present invention relates to a gene testing method and a gene testing apparatus for extracting nucleic acid from a biological sample and performing gene amplification using the polymerase chain reaction (hereinafter abbreviated as PCR).

Background Art

[0002] As an example of a specimen processing apparatus for preventing deterioration of a specimen and a reagent due to an increase in standby time other than reaction and improving the operating efficiency of the apparatus, Patent Document 1 describes at least two independent reaction units for reacting specimens respectively, an input / output terminal for inputting an upper limit value of standby time other than the reaction of the specimen and a reaction time of the specimen, and based on the upper limit value of standby time other than the reaction input at the input / output terminal and the reaction time, a schedule management unit for determining any one or more of the input time of the specimen, the reaction unit used for processing the specimen, and the standby time other than the reaction of the specimen, and an overall control unit for controlling to process the specimen in the plurality of reaction units based on the determination by the schedule management unit.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] The PCR method is used in an apparatus for analyzing nucleic acid contained in a biological specimen (so-called biological sample) such as blood or urine. The PCR method is a technique for amplifying a target nucleic acid by raising and lowering the temperature using a heat-resistant polymerase and a primer, and is widely used in fields such as genetic engineering, biological test methods, and biological detection methods.

[0005] The principle of PCR is to geometrically amplify target DNA by repeating a cycle that follows a thermal profile (temperature rise and fall) many times.

[0006] Quantitative testing methods that utilize PCR include real-time PCR or quantitative polymerase chain reaction (hereinafter abbreviated as qPCR). qPCR is a highly sensitive gene analysis method and is increasingly being applied to clinical tests such as quantitative gene expression analysis, pathogen detection, and drug target verification.

[0007] Genetic testing using these technologies requires approximately two hours because it involves a single process from extraction to PCR measurement. Furthermore, genetic testing using these technologies typically employs a batch processing method, where multiple biological samples are loaded and processed simultaneously.

[0008] In recent years, these genetic testing devices have become widespread, particularly in university hospitals and clinical testing centers that need to process biological samples from many patients in a short time. However, within these hospitals, accelerating diagnoses for patients requiring urgent attention remains a challenge. Furthermore, for items related to airborne infections, failure to quickly determine results can lead to secondary infections within the hospital, highlighting the extremely high need for rapid diagnosis to enable prompt responses.

[0009] Against this backdrop, there is a growing need for rapid measurement of emergency samples using genetic testing equipment.

[0010] Conventional technologies have proposed attempts to rapidly measure emergency samples. For example, Patent Document 1 proposes setting an upper limit on the waiting time other than the reaction of the sample, and controlling the delivery of the sample within that time.

[0011] However, in actual hospital operations, blood samples are collected or prepared in advance, and these samples are then fed into the equipment as they arrive in the laboratory. In other words, it is difficult for the equipment to control the timing of sample delivery.

[0012] As mentioned above, genetic testing devices generally utilize a batch processing system that processes multiple biological samples simultaneously. This is because each measurement takes several hours, and by performing multiple identical measurements at the same time, the number of measurements per unit of time is ensured. When used for research purposes such as drug discovery, the priority of each sample is the same, and the items being measured are also mainly the same, so this method does not pose a major problem.

[0013] However, when measuring biological samples from unspecified patients, the priorities and test items often differ for each sample. Furthermore, the time it takes for each sample to arrive at the laboratory and become ready for measurement also varies.

[0014] Therefore, it is necessary to process samples according to the priority given to each sample and test item. In particular, it is necessary to prioritize the measurement of urgent samples that are deemed to have a high priority.

[0015] However, if we simply focus on the priority of the samples and prioritize processing accordingly, there is a risk that if high-priority samples are submitted consecutively, lower-priority samples may be delayed indefinitely, and results may never be obtained.

[0016] Furthermore, in these hospital-grade genetic testing devices, the sample input area is designed solely for sample input. In other words, the technician simply inputs the arriving samples in order. On the other hand, the device itself is designed to process multiple samples together. Similarly, the PCR processing also processes multiple samples together. This means that if multiple parameters are not processed together, the overall efficiency will decrease, which presents a challenge.

[0017] Furthermore, since PCR testing takes several hours, leaving samples at room temperature for too long is undesirable as it can lead to degradation such as evaporation.

[0018] Therefore, while submitted samples should be processed promptly, measurement processing must also be carried out with consideration for sample priority and equipment operating efficiency.

[0019] The present invention provides a gene testing method and gene testing apparatus that prioritize the measurement of high-priority samples while also preventing low-priority samples from having to wait indefinitely even if high-priority samples are submitted consecutively. [Means for solving the problem]

[0020] The present invention includes multiple means for solving the above problems, but to give one example, a gene testing method that performs an input step of introducing a sample, a pre-processing step of acquiring biomolecules including a target for measurement from the sample introduced in the input step, a measurement step of measuring the biomolecules acquired in the pre-processing step, and an analytical data processing step of performing analytical calculation processing based on the measurement results in the measurement step, wherein a calculation step is further performed to calculate a target time until dispensing of the sample is completed by adding a waiting time according to the priority of the sample to the time the sample was introduced, and the dispensing process of the sample is performed in the order of the target time. [Effects of the Invention]

[0021] According to the present invention, it is possible to prioritize the measurement of high-priority samples, and even if high-priority samples are continuously introduced, it is possible to avoid long delays in measuring lower-priority samples. Problems, configurations, and effects other than those described above will be clarified by the following description of the examples. [Brief explanation of the drawing]

[0022] [Figure 1] A figure showing one embodiment of a gene testing device to which the present invention is applied. [Figure 2] Figure showing a setting screen for a specimen waiting for dispensing used in an embodiment of a gene testing apparatus to which the present invention is applied. [Figure 3] Figure showing a specimen and a specimen rack used in an embodiment of a gene testing apparatus to which the present invention is applied. [Figure 4] An example of a flowchart for calculating the target for the end of dispensing in an embodiment of a gene testing apparatus to which the present invention is applied. [Figure 5] Figure showing an example of a dispensing order management table in an embodiment of a gene testing apparatus to which the present invention is applied. [Figure 6] Figure showing an example of a dispensing order management table in an embodiment of a gene testing apparatus to which the present invention is applied. [Figure 7] Figure showing an example of a dispensing order management table in an embodiment of a gene testing apparatus to which the present invention is applied.

Embodiments for Carrying Out the Invention

[0023] Examples of the gene testing method and gene testing apparatus of the present invention will be described with reference to FIGS. 1 to 7. In the drawings used in this specification, the same or corresponding components are denoted by the same or similar reference numerals, and repeated descriptions of these components may be omitted.

[0024] First, the overall configuration of the gene testing apparatus will be described with reference to FIG. 1. FIG. 1 is a block diagram showing an overview of the gene testing apparatus of this embodiment. Here, a gene testing apparatus 1 for transporting a specimen rack equipped with a plurality of specimen containers is assumed.

[0025] The gene testing apparatus 1 shown in FIG. 1 includes a specimen rack input unit 11, a specimen rack buffer unit 12, a first dispensing unit 16a, nucleic acid extraction units 13a, 13b, a second dispensing unit 16b, amplification units 14a, 14b, 14c, a control computer 2, and the like.

[0026] The sample rack loading section 11 is the part for loading and retrieving sample racks, and has a barcode reader 11a that reads the priority of the sample when a sample is loaded. In this sample rack loading section 11, the loading step of loading a sample is preferably performed, and the reading step of reading the priority of the sample when a sample is loaded is preferably performed by the barcode reader 11a.

[0027] The sample rack buffer section 12 is a section that temporarily stores one or more sample racks that hold sample containers containing samples awaiting analysis, which have been inserted from the sample rack input section 11, and also temporarily stores one or more sample racks before they are retrieved.

[0028] The first dispensing unit 16a is the part that dispenses samples from sample containers placed on sample racks on the sample rack input unit 11 or the sample rack buffer unit 12 to the nucleic acid extraction units 13a and 13b. It has drive mechanisms in the X, Y, and Z axes, and a dispensing probe, and moves above the sample rack input unit 11, the sample rack buffer unit 12, and the nucleic acid extraction units 13a and 13b. The first dispensing step, in which samples are dispensed from the input step to the pre-processing step, is preferably performed in this first dispensing unit 16a.

[0029] The nucleic acid extraction units 13a and 13b are responsible for obtaining biomolecules, including the target of measurement, from the samples loaded into the sample rack loading unit 11. In these nucleic acid extraction units 13a and 13b, a pre-treatment step is preferably performed to obtain biomolecules, including the target of measurement, from the samples loaded in the loading step.

[0030] The second dispensing section 16b is the part that dispenses biomolecules from the nucleic acid extraction sections 13a and 13b to the amplification sections 14a, 14b, and 14c. Similar to the first dispensing section 16a, it has drive mechanisms in the X, Y, and Z axes, and a dispensing probe, and moves above the nucleic acid extraction sections 13a and 13b and the amplification sections 14a, 14b, and 14c. The second dispensing step, in which biomolecules are dispensed from the pretreatment step to the measurement step, is preferably performed in this second dispensing section 16b.

[0031] The amplification sections 14a, 14b, and 14c are the parts that measure the biomolecules obtained in the nucleic acid extraction sections 13a and 13b. In these amplification sections 14a, 14b, and 14c, a measurement step is preferably performed to measure the biomolecules obtained in the pretreatment step.

[0032] Here, we show an example where the nucleic acid extraction sections 13a and 13b consist of two parts, a and b, and the amplification sections 14a, 14b, and 14c consist of three parts, a, b, and c. However, this is just one example, and there can be one or four or more parts. Similarly, we show an example where the first dispensing section 16a or the second dispensing section 16b each consist of one part, but there can be two or more parts for each.

[0033] Furthermore, a control computer 2 is connected to the gene testing device 1 via a communication line 3.

[0034] The control computer 2 consists of a display unit 2a, an analysis data processing unit 2b, a control unit 2c, a calculation unit 2d, an information storage unit 2e, and the like.

[0035] The display unit 2a is a touch panel type display that also serves as an input unit, and displays various information about the gene testing device 1, information about the sample to be analyzed, and information necessary to perform the analysis. A separate input device such as a mouse or keyboard may be provided as an input unit.

[0036] The analysis data processing unit 2b is the part that performs analysis calculations based on the measurement results from the amplification units 14a, 14b, and 14c. Preferably, the analysis data processing step is executed in this analysis data processing unit 2b, which performs analysis calculations based on the measurement results from the measurement step.

[0037] The control unit 2c is the part that controls the operation of each part of the gene testing device 1 individually or as a whole. In this embodiment, the control unit 2c controls the operation of the first dispensing unit 16a so that the sample dispensing process is performed in the order of the target times determined by the calculation unit 2d, which will be described later. Specifically, the sample dispensing process is performed in the order of the target times.

[0038] Furthermore, the control unit 2c can issue a warning when the target time is exceeded.

[0039] In this control unit 2c, if the target time is exceeded, a warning step is issued, and the first dispensing step is executed to perform the sample dispensing process in the order of the target time.

[0040] The calculation unit 2d is the part that calculates the target time until dispensing of the sample is completed by adding a waiting time according to the priority of the sample to the time the sample is entered. Preferably, the calculation step of adding a waiting time according to the priority of the sample to the time the sample is entered and calculating the target time until dispensing of the sample is completed is performed in this calculation unit 2d.

[0041] The information storage unit 2e stores, for example, control parameters corresponding to each unit and sample information related to various samples, and is a recording medium that confirms and stores priority. In this information storage unit 2e, the information storage step of confirming and storing priority is preferably executed.

[0042] Of the control computer 2, the analysis data processing unit 2b, the control unit 2c, and the arithmetic unit 2d may be configured as hardware using a dedicated circuit board, or as software executed on a computer. When configured as hardware, this can be achieved by integrating multiple arithmetic units that perform the processing on a wiring board, or within a semiconductor chip or package. When configured as software, this can be achieved by equipping a computer with a high-speed general-purpose CPU and running a program that performs the desired arithmetic processing. Existing equipment can also be upgraded using a recording medium on which this program is stored. Furthermore, these devices, circuits, and computers are connected by a wired or wireless network, and data is transmitted and received as needed.

[0043] The above describes the configuration of the gene testing device 1 in this embodiment.

[0044] The following is a brief explanation of the analysis process using Genetic Testing Device 1.

[0045] When a sample rack 31, on which sample containers 33 are placed, is set up in the sample rack input section 11 and analysis is started, the sample rack is pulled into the sample rack buffer section 12.

[0046] Depending on the requested specifications, nucleic acid extraction operations are performed in nucleic acid extraction units 13a and 13b.

[0047] The extracted solution is transferred to amplification units 14a, 14b, and 14c, and reacted with reagents placed in the reagent placement unit 15. Here, the target DNA is geometrically amplified and detected by repeatedly controlling the temperature according to the thermal profile.

[0048] The specimen container 33 is placed on a specimen rack 31 as shown in Figure 3. Generally, the specimen racks 31 are color-coded according to the priority of the specimens placed on them. For example, specimen racks for urgent specimens are red, and specimen racks for general specimens are gray. This is to allow laboratory technicians to easily identify which specimen rack to place a specimen in according to its priority when placing specimens.

[0049] As a device, directly identifying colors would require incorporating expensive equipment such as image processing devices. Therefore, information that identifies the priority of the sample rack is written on the rack barcode 32, and by reading this information with the barcode reader 11a, the priority of each sample placed on that rack is identified.

[0050] A sample barcode 34 is affixed to the sample container 33 to identify the sample itself. This information is read by the barcode reader 11a to identify each sample.

[0051] Although not mentioned in the text, the barcode information of the specimen and the request information for the specimen are paired and registered in a higher-level host computer such as the HIS (Hospital Information System). After reading the specimen barcode information, the device queries the higher-level host computer to determine the request information for which the specimen should be measured.

[0052] In this embodiment, a gene testing apparatus using a sample rack is described, but it is not necessarily required to load samples into a sample rack. A single sample holder may be used, or the gene testing apparatus may be designed so that the sample is placed directly by the laboratory technician.

[0053] Furthermore, although Figure 3 shows the sample rack with five sample containers, it may have one, or a different number such as ten, and is not particularly limited.

[0054] The priority of incoming specimens is determined by information linked to the host computer (omitted for illustrative purposes) or specimen information. Generally, there are two types of specimens: general specimens, which are treated as normal patient specimens, and emergency specimens, which must be measured quickly.

[0055] In this embodiment, two priorities are defined, but three, four, or more priorities may be established. In this case, a waiting time is set for each different priority, and the target time until dispensing is completed is calculated for each.

[0056] In Figure 2, a dispensing-wait sample setting screen 21 is displayed on the display unit 2a, which registers the time that each sample can wait in the device for each of these sample priorities.

[0057] The dispensing-await sample setting screen 21 displayed on the display unit 2a allows input into a general sample waiting time setting field 22 for setting the waiting time for general samples in the sample rack buffer section 12, and an emergency sample waiting time setting field 23 for setting the waiting time for emergency samples in the sample rack buffer section 12. The input settings in these general sample waiting time setting fields 22 and emergency sample waiting time setting fields 23 constitute the time setting step for setting the waiting time.

[0058] The settings on this specimen settings screen 21 are pre-configured by the hospital administrator or by a service technician during the installation of the device.

[0059] When the OK button 26 is pressed, the entered value is recorded as the waiting time, and when the Cancel button 27 is pressed, the dispensing waiting sample setting screen 21 is closed.

[0060] Next, the procedure for scheduling sample dispensing and analysis, which forms the core of the present invention, will be explained using Figures 4 to 7.

[0061] As explained earlier, generally, the sample container containing the sample is placed on the sample rack 31, the rack barcode 32 and the sample barcode 34 are read by the barcode reader 11a, and then the sample is placed in the sample rack input unit 11. At this time, the target time for completion of dispensing is determined according to the flow in Figure 4.

[0062] As shown in Figure 4, the calculation unit 2d starts the process of calculating the target time for completion of dispensing when a sample is added.

[0063] First, the calculation unit 2d determines the sample priority (S101). If the sample priority is a general sample, the process proceeds to S102, where the time the sample can wait, i.e., the target time when dispensing will be completed, is determined using the formula "Target dispensing completion time" = "Rack placement time" + "General sample waiting time (time entered in the general sample waiting time setting field 22)" (S102), and the process ends.

[0064] In contrast, if the sample priority is an urgent sample, the process proceeds to S103, and the time during which the sample can wait, i.e., the target time for dispensing to be completed, is determined by the formula "Target dispensing completion time" = "Time of rack placement" + "Emergency sample waiting time (time entered in the emergency sample waiting time setting field 23)" (S103), and the process is terminated.

[0065] This result is reflected in the dispensing order management table 201 in Figure 5.

[0066] Here, we assume that the waiting time for general samples is set at 40 minutes and the waiting time for emergency samples is set at 20 minutes. The target dispensing completion time is determined based on the sequential input of samples between 08:45 and 09:00, and the samples are arranged sequentially according to this time.

[0067] Subsequently, as shown in Figure 6, if an emergency sample with sample ID 0000101 is delivered at 09:15, S103 calculates the target dispensing completion time as 09:35, and this information is generated as the dispensing order management table 202.

[0068] This information is added to the dispensing order management table 201, and as shown in Figure 7, the dispensing order management table 203 is created after the emergency sample is delivered. Here, the target dispensing completion time for the added emergency sample is 09:35, which is the same time as the sample ID, 0000003. In the case of the same time, the sample is registered first according to its priority. This can also be explained by the logic that samples that were submitted first are given priority.

[0069] The samples placed in the device are dispensed according to the dispensing order management table 203, and then measured after passing through the nucleic acid extraction section 13a, 13b and the amplification section 14a, 14b, 14c.

[0070] A simplistic approach would result in creating a dispensing order management table 203 based on the priority of the samples. In this case, the emergency sample with sample ID 0000101 would be placed at the top. If emergency samples arrive consecutively afterward, they would be assigned before the general sample with sample ID 0000001, meaning the general sample would never be measured. In other words, there is a risk of accelerating sample deterioration.

[0071] However, in this embodiment, a waiting time limit is set even for general samples, so that the speed of measurement due to interruptions by urgent samples is maintained while minimizing delays in general samples caused by interruptions. In other words, it is possible to provide a genetic testing device that can prevent sample degradation that would affect analytical performance due to prolonged waiting in the device.

[0072] In this embodiment, two nucleic acid extraction units 13a and 13b are considered, and three amplification units 14a, 14b, and 14c are considered.

[0073] If any of the devices malfunctions, for example, if one of the nucleic acid extraction units 13a and 13b fails and the system is forced to operate with only one unit, the nucleic acid extraction process for all samples must be completed, which will inevitably reduce the overall processing speed. In such a case, it is not guaranteed that the sample dispensing will be completed by the target dispensing completion time, and there is a high possibility that it will be exceeded.

[0074] To prepare for situations like this, a warning can be issued to the operator according to the settings in the standby time exceedance warning setting field 24. This warning allows the operator to recognize that the set time has been exceeded.

[0075] Furthermore, if the target time is exceeded, the system can either continue to wait for the sample to be dispensed even if the time is exceeded, or cancel the measurement and collect the sample, according to the setting field 25 for continuing measurement after the waiting time has been exceeded.

[0076] The input setting in the "Measurement continuation setting field 25 when waiting time is exceeded" is a setting step that determines whether or not to perform measurement of the relevant sample when the target time is exceeded.

[0077] Next, the effects of this embodiment will be described.

[0078] The gene testing apparatus 1 of this embodiment described above comprises a sample rack input unit 11 for inputting samples, nucleic acid extraction units 13a and 13b for acquiring biomolecules including the target for measurement from the samples input in the sample rack input unit 11, amplification units 14a, 14b, and 14c for measuring the biomolecules acquired by the nucleic acid extraction units 13a and 13b, an analysis data processing unit 2b for performing analysis calculations based on the measurement results from the amplification units 14a, 14b, and 14c, and a control unit 2c for individually or collectively controlling the operation of each part of the apparatus. It further comprises a calculation unit 2d that calculates a target time until the completion of dispensing of samples by adding a waiting time according to the priority of the samples to the time the samples are input, and the control unit 2c performs the dispensing process of samples in the order of the target time.

[0079] In this type of genetic testing device 1, samples are processed in order of shortest expiration date, thereby prioritizing the measurement of high-priority samples. On the other hand, since processing is not performed solely on priority, even if high-priority samples are submitted consecutively, it is possible to avoid long delays in measuring lower-priority samples.

[0080] Furthermore, the system includes a general sample waiting time setting field 22 and an emergency sample waiting time setting field 23, allowing for timely changes to the waiting time according to the operating status of the device and the operator's circumstances, thereby enabling more flexible analysis.

[0081] Furthermore, by adding a barcode reader 11a that reads the priority of the sample when it is inserted, the user no longer needs to manually enter the priority each time, thereby reducing their burden.

[0082] Furthermore, the control unit 2c issues a warning when the target time is exceeded, allowing it to determine whether it is necessary to take measures such as re-collecting or re-inserting the sample, thus enabling accurate analysis results even in the event of trouble.

[0083] Furthermore, by providing a setting field 25 for continuing measurement when the waiting time is exceeded, which allows setting whether or not to continue measuring the sample in question when the target time is exceeded, it is possible to set whether or not to analyze a sample that may have deteriorated due to prolonged waiting, according to the operating status of the device and the circumstances of the operator, thereby enabling more flexible analysis.

[0084] Furthermore, the system includes a first dispensing unit 16a that dispenses samples from the sample rack input unit 11 to the nucleic acid extraction units 13a and 13b, and a second dispensing unit 16b that dispenses biomolecules from the nucleic acid extraction units 13a and 13b to the amplification units 14a, 14b, and 14c. The control unit 2c controls the operation of the first dispensing unit to dispense samples in the order of the target time, thereby prioritizing the measurement of high-priority samples while avoiding prolonged waiting for the measurement of low-priority samples.

[0085] <Other> It should be noted that the present invention is not limited to the embodiments described above, and various modifications and applications are possible. The embodiments described above are explained in detail for the purpose of clearly illustrating the present invention, and are not necessarily limited to those having all the configurations described. [Explanation of Symbols]

[0086] 1: Genetic testing device 2: Control computer 2a: Display section 2b: Analysis Data Processing Unit 2c: Control Unit 2d: Arithmetic section 2e: Information storage section 3: Communication lines 11: Specimen rack loading section (loading section) 11a: Barcode reader 12: Specimen rack buffer section 13a, 13b: Nucleic acid extraction section (pre-treatment section) 14a, 14b, 14c: Amplification section (measurement section) 15: Reagent installation section 16a: First dispensing area 16b: Second dispensing area 21: Sample waiting to be dispensed setting screen 22: General sample waiting time setting field 23: Setting field for emergency sample waiting time 24: Warning setting field when standby time exceeds 25: Setting field for continuing measurement when standby time is exceeded (settings section) 26: OK button 27: Cancel button 31: Specimen rack 32: Rack barcode 33: Specimen container 34: Sample barcode 201, 202, 203: Dispensing Order Management Table

Claims

1. The sample is added in the input step, A pre-processing step to obtain biomolecules including the target to be measured from the sample introduced in the aforementioned input step, A measurement step for measuring the biomolecules obtained in the pre-processing step, A gene testing method that performs an analysis data processing step, which performs analysis calculation processing based on the measurement results in the measurement step, Further calculation steps are performed to calculate the target time until dispensing of the sample is completed by adding a waiting time according to the priority of the sample to the time the sample was added. The sample dispensing process is performed in the order of the target times. Genetic testing methods.

2. In the gene testing method described in claim 1, The time setting step for setting the waiting period is further performed. Genetic testing methods.

3. In the gene testing method described in claim 1, When the aforementioned sample is introduced, a reading step is further performed to read the priority of the aforementioned sample. Genetic testing methods.

4. In the gene testing method described in claim 1, Further, perform the information storage step of confirming and remembering the aforementioned priority. Genetic testing methods.

5. In the gene testing method described in claim 1, If the aforementioned target time is exceeded, a warning step is further executed to issue a warning. Genetic testing methods.

6. In the gene testing method described in claim 1, If the aforementioned target time is exceeded, a setting step is further executed to determine whether or not to perform the measurement of the relevant sample. Genetic testing methods.

7. In the gene testing method described in claim 1, From the input step to the first dispensing step in which the sample is dispensed in the pre-processing step, The system further comprises a second dispensing step in which the biomolecules are dispensed in the measurement step, following the pretreatment step, The first dispensing step is executed to perform the dispensing process of the samples in the order of the target times. Genetic testing methods.

8. The input section for inserting the sample, A preprocessing unit for acquiring biomolecules, including the target of measurement, from the sample introduced into the input unit, A measurement unit for measuring the biomolecules acquired in the preprocessing unit, An analysis data processing unit performs analysis calculations based on the measurement results from the measurement unit, A gene testing apparatus comprising a control unit that individually or collectively controls the operation of each part within the apparatus, The system further includes a calculation unit that adds a waiting time corresponding to the priority of the sample to the time the sample is introduced, and calculates a target time until the dispensing of the sample is completed. The control unit performs the dispensing process of the samples in the order of the target times. Genetic testing device.

9. In the gene testing apparatus according to claim 8, The system further includes a time setting unit for setting the standby time. Genetic testing device.

10. In the gene testing apparatus according to claim 8, The system further includes a reading unit that reads the priority of the sample when the sample is introduced. Genetic testing device.

11. In the gene testing apparatus according to claim 8, The system further comprises an information storage unit that confirms and stores the aforementioned priority. Genetic testing device.

12. In the gene testing apparatus according to claim 8, The control unit issues a warning when the target time is exceeded. Genetic testing device.

13. In the gene testing apparatus according to claim 8, The system further includes a setting unit that determines whether or not to perform measurement of the relevant sample when the aforementioned target time is exceeded. Genetic testing device.

14. In the gene testing apparatus according to claim 8, A first dispensing unit that dispenses the sample from the input unit to the pre-processing unit, The system further comprises a second dispensing unit for dispensing the biomolecules from the preprocessing unit to the measurement unit, The control unit controls the operation of the first dispensing unit to perform the dispensing process of the samples in the order of the target time. Genetic testing device.

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