Detection device and analysis device

Abstract

Provided is a detection device capable of easily detecting an object to be detected in a sample. A detection device (6) according to an embodiment of the present invention is for detecting an antibody (92) in a sample (9) containing a magnetic insulating material (91), and comprises a cylindrical flow path (61) through which the sample (9) is caused to flow downstream. The flow path (61) has: a body part (611) having insulating properties; and an electric conductor (612) provided at a portion of a cross-section perpendicular to a downstream direction. In the body part (611), a counter unit (614) opposite the electric conductor (612) is formed. The detection device (6) further comprises: a measuring unit (62) that measures at least one of a current and a voltage in the electric conductor (612); and a temperature control unit (63) that generates a temperature difference between the electric conductor (612) side of the flow path (61) and the counter unit (614) side of the flow path (614).

Description

Technical Field

[0006] , ,

[0005] , , ,

[0001] The present invention relates to a detection device and an analysis device for detecting a detection target of a liquid sample.

Background Art

[0002] Conventionally, as a technique for detecting a detection target of a liquid sample, the detection method of Patent Document 1 has been disclosed.

[0003] / The detection method of Patent Document 1 uses a flow path type sensor chip in which one of two substances that specifically bind to each other is fixed as a fixed layer on the wall surface of the flow path of a flow path member having a micro flow path through which a liquid sample flows. A liquid sample containing a substance to be detected is caused to flow down in the flow path, and an amount of a binding substance corresponding to the amount of the substance to be detected is bound to the fixed layer. Then, in the flow path, the liquid is moved at a flow rate such that the shear stress applied to the fixed layer is within a predetermined range, so that the non-specifically adsorbed binding substance on the fixed layer is removed. After that, a signal from the binding substance on the fixed layer is detected. [[ID=1E]]

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] By the way, in the detection method of Patent Document 1, after removing the non-specifically adsorbed binding substance on the fixed layer, a signal from the binding substance on the fixed layer is detected. For this reason, it is necessary to control the flow rate within a predetermined range, and there is a problem that it is difficult to easily detect the detection target of the sample. [[ID=E0]]

[0006] Therefore, the present invention has been devised in view of the above circumstances, and an object thereof is to provide a technique that enables easy detection of a detection target of a sample. [Means for solving the problem]

[0007] The detection device according to the present invention is The detected substance is transmitted via the binder. Magnetic insulator A complex formed by binding to Sample containing , the above A detection device for detecting an object to be detected, comprising a cylindrical channel for the flow of the sample, wherein the channel comprises a main body and a conductor provided in a part of the cross section perpendicular to the flow direction, the main body having a facing portion facing the conductor, and further comprising a measuring unit for measuring at least one of the current and voltage in the conductor, and a temperature control unit for generating a temperature difference between the conductor side of the channel and the facing portion side of the channel.

[0008] The analytical apparatus according to the present invention is an analytical apparatus for analyzing a target object, equipped with the detection device of the present invention, and further comprising an evaluation unit that quantifies the target object based on at least one of the current and voltage measured by the measurement unit. [Effects of the Invention]

[0009] According to the present invention, it is possible to provide a technology that makes it possible to easily detect the target object in a sample. [Brief explanation of the drawing]

[0010] [Figure 1] Figure 1 is a schematic diagram showing an example of an analytical apparatus in the first embodiment. [Figure 2] Figure 2 shows an example of a detection device. [Figure 3] Figure 3 shows an example of a cross-section perpendicular to the flow direction of the detection device's flow path. [Figure 4] Figure 4 shows an example of a detection device. Figure 4(a) shows a cross-section perpendicular to the flow direction of the channel through the conductor, and Figure 4(b) shows a cross-section perpendicular to the flow direction of the channel through the magnet. [Figure 5] Figure 5 shows an example of the relationship between antibody content and current and voltage. [Figure 6] Figure 6 shows an example of a method for detecting a target object in a sample using a detection device. Figure 6(a) shows the state before current is generated in the conductor, and Figure 6(b) shows the state after current is generated in the conductor. [Figure 7] Figure 7 shows an example of a detection device in the first modified example. [Figure 8] Figure 8 shows an example of a cross-section perpendicular to the flow direction of the flow path of the detection device in the first modified example. [Figure 9] Figure 9 shows an example of a detection device in the first modified example, where Figure 9(a) shows a cross-section perpendicular to the flow direction of the channel through the conductor, and Figure 9(b) shows a cross-section perpendicular to the flow direction of the channel through the magnet. [Figure 10] Figure 10 shows an example of a method for detecting the target object in a sample using the detection device in the first modified example. Figure 10(a) shows the state before current is generated in the conductor, and Figure 10(b) shows the state after current is generated in the conductor. [Modes for carrying out the invention]

[0011] The following describes in detail, with reference to the drawings, embodiments for implementing a detection and analysis device to which the present invention is applied.

[0012] <First Embodiment: Analytical Apparatus 100> As shown in Figure 1, the analysis device 100 comprises a detection device 6, a measurement unit 62, and an information processing device 4. The analysis device 100 analyzes a sample 9 containing a magnetic insulator 91. The magnetic insulator 91 can be, for example, yttrium iron garnet.

[0013] <Detection device 6> Figure 2 shows an example of a detection device 6. As shown in Figure 2, the detection device 6 detects the target object of the sample 9, which includes a magnetic insulator 91. The detection device 6 has a flow path 61, a measurement unit 62, and a temperature control unit 63.

[0014] <<Flow path 61>> The flow path 61 is formed in a cylindrical shape, and the sample 9 flows down. The flow path 61 has a main body portion 611, a conductor 612, and a magnet 613. A flow rate control device (not shown) for controlling the flow rate and the timing of the flowing-down sample 9 may be provided in the flow path 61. The flow rate control device controls the flow rate and the timing of the flowing-down sample 9 flowing into the flow path 61 by the processing unit 49. The flow path 61 has an injection port 61a for injecting the sample 9 at one end side and a discharge port 61b for discharging the sample 9 at the other end side.

[0015] As shown in FIG. 3, the main body portion 611 is made of an insulator such as silicon and has insulation properties. The main body portion 611 is formed in a U-shape in a cross section orthogonal to the flowing-down direction of the flow path 61. A conductor 612 is provided in a part of the cross section orthogonal to the flowing-down direction of the flow path 61 in the main body portion 611, and an opposing portion 614 opposing the conductor is formed.

[0016] As shown in FIG. 4(a), the conductor 612 is provided in the main body portion 611 of the flow path 61. The conductor 612 has conductivity and is made of, for example, platinum. The conductor 612 is formed in a plate shape.

[0017] As shown in FIG. 4(b), the magnet 613 is provided on the side of the conductor 612 of the flow path 61 in a part of the cross section orthogonal to the flowing-down direction of the flow path 61. The magnet 613 is provided in contact with the conductor 612. The magnet 613 is, for example, an electromagnet 613a. The electromagnet 613a is connected to a current control device (not shown). When a current flows through the electromagnet 613a by the current control device, the electromagnet 613a can attract or attach a sample containing a magnetic insulator to the electromagnet 613a. When no current flows through the electromagnet 613a by the current control device, the sample attached by the electromagnet 613a can be detached from the electromagnet 613a.

[0018] <<Measurement unit 62>> As shown in Figure 2, the measuring unit 62 is electrically connected to the conductor 612 and measures at least one of the current and voltage generated in the conductor 612. The measuring unit 62 uses a known device capable of measuring at least one of the current and voltage.

[0019] <<Temperature control unit 63>> The temperature control unit 63 generates a temperature difference between the conductor 612 side of the flow path 61 and the opposing side 614 of the flow path 61. At this time, a temperature difference is generated in the magnetic insulator 91 contained in the sample 9 within the flow path 61. Due to the temperature difference, a spin current flows in the magnetic insulator 91, and this spin current flows into the conductor 612. This generates an electric current in the conductor 612, causing the spin Seebeck effect to occur. By measuring at least one of the current generated in the conductor 612 and the voltage associated with this current using the measurement unit 62, the presence or absence of a target object contained in the sample 9 can be detected.

[0020] The temperature control unit 63 controls the temperature of the channel 61 on the magnet 613 side to be higher than the temperature of the channel 61 on the opposite side 614 side, for example, by cooling the opposite side 614 of the channel 61.

[0021] As shown in Figure 3, the temperature control unit 63 includes a Peltier element 64, a current generator 65, a first wiring 66, and a second wiring 67.

[0022] As shown in Figure 4(b), the Peltier element 64 is provided in contact with the conductor 612 and the magnet 613 on opposite sides of the flow path 61. A known Peltier element is used for the Peltier element 64. As shown in Figure 3, the Peltier element 64 has a first electrode portion 641, an N-type semiconductor 642, a P-type semiconductor 643, a second electrode portion 644, and a third electrode portion 645.

[0023] The first electrode portion 641 may be made of a metal such as platinum or copper. As shown in Figure 4(b), the first electrode portion 641 is in contact with the insulating opposing portion 614. The first electrode portion 641 is in contact with the main body portion 611 of the flow path 61 on the opposite side of the flow path 61 from the conductor 612 and the magnet 613. The first electrode portion 641 may be made of metal and may have a substrate or the like attached to it.

[0024] As shown in Figure 3, known semiconductors are used for the N-type semiconductor 642 and the P-type semiconductor 643. The N-type semiconductor 642 and the P-type semiconductor 643 are provided on the first electrode portion 641, spaced apart from each other.

[0025] The second electrode portion 644 may be made of a metal such as platinum or copper. The second electrode portion 644 is located on the opposite side of the first electrode portion 641, with the N-type semiconductor 642 in between. The metal constituting the second electrode portion 644 may be provided with a substrate such as ceramic.

[0026] The third electrode portion 645 may be made of a metal such as platinum or copper. The third electrode portion 645 is provided on the opposite side of the first electrode portion 641, with the P-type semiconductor 643 in between. A substrate such as ceramic may be provided on the metal constituting the third electrode portion 645.

[0027] The current generator 65 supplies current to the Peltier element 64. The positive side of the current generator 65 is electrically connected to the second electrode section 644 via the first wiring 66. The negative side of the current generator 65 is electrically connected to the third electrode section 645 via the second wiring 67.

[0028] When current is applied to the Peltier element 64 by the current generator 65, heat is absorbed on the first electrode portion 641 side, and heat is dissipated on the second electrode portion 644 side and the third electrode portion 645 side. Since the first electrode portion 641 is in contact with the opposing portion 614, the temperature control unit 63 can cool the first electrode portion 641 side and the opposing portion 614 side of the flow path 61. As a result, the temperature control unit 63 can control the temperature of the magnet 613 side of the flow path 61 so that it is higher than the temperature of the opposing portion 614 side of the flow path 61.

[0029] <Information Processing Device 4> The information processing device 4 may be, for example, a personal computer. The information processing device 4 may further include an input / output unit for inputting and outputting various types of information, and a storage unit for storing various types of information.

[0030] The information processing device 4 includes, for example, an evaluation unit 43. The information processing device 4 stores, for example, the relationship between at least one of the current and voltage measured in advance by the measurement unit 62 and the content of the substance to be detected in the sample 9. For example, as shown in Figure 5, the information processing device 4 stores the relationship between at least one of the current and voltage measured by the measurement unit 62 and the content of the antibody, which is the substance to be detected in the sample 9. The information processing device 4 can control the flow rate and timing of the sample 9 flowing down the flow path 61 using the processing unit 49.

[0031] <<Evaluation Section 43>> The evaluation unit 43 quantifies the content of the target substance in sample 9 based on at least one of the current and voltage measured by the measurement unit 62. The evaluation unit 43 refers to the relationship between at least one of the current and voltage measured by the measurement unit 62 and the content of the target substance in sample 9, stored in, for example, the information processing device 4, and quantifies the content of the target substance in sample 9 based on at least one of the current and voltage measured by the measurement unit 62. This makes it easy to quantify the content of the target substance in sample 9. For example, the content of antibodies, antigens, enzymes, substrates, etc., contained in sample 9 can be quantified.

[0032] (An example of a method for detecting the target object of sample 9 using detection device 6) Next, an example of a method for detecting the target substance in sample 9 using the detection device 6 will be described. Figure 6 shows an example of a method for detecting the target substance in sample 9 using the detection device 6. Sample 9 contains a magnetic insulator 91. The magnetic insulator 91 is bound to antibody 92 via a binder such as streptavidin. Antibody 92 is bound to antigen 93. In the following example, antibody 92 is used as the target substance. The target substance may also be antigen 93. Note that the target substance may also be an enzyme or a substrate.

[0033] As shown in Figure 6(a), the sample 9 is allowed to flow down the channel 61. At this time, the temperature control unit 63 cools the opposite side 614 of the channel 61 so that the temperature on the conductive side 612 of the channel 61 is higher than the temperature on the opposite side 614 of the channel 61. This creates a temperature difference between the conductive side 612 of the channel 61 and the opposite side 614 of the channel 61.

[0034] As shown in Figure 6(b), when the sample 9 reaches the conductor 612 and the electromagnet 613a, the sample 9 is stopped inside the flow path 61. As a result, the magnetic insulator 91 contained in the sample 9 is attracted to the vicinity of the electromagnet 613a and adheres to it.

[0035] A temperature difference occurs between the conductor 612 side of the channel 61 and the opposing side 614 of the channel 61, resulting in a temperature difference in the magnetic insulator 91 contained in the sample 9. This temperature difference causes a spin current to flow through the magnetic insulator 91, and this spin current flows into the conductor 612. As a result, the spin Seebeck effect occurs, generating an electric current in the conductor 612.

[0036] Then, with the sample 9 stopped inside the flow path 61, the current generated in the conductor 612 is measured by the measurement unit 62. Since the sample 9 contains the antibody 92, which is the target substance for detection, the antibody 92 can be detected as the target substance by the current measured by the measurement unit 62. The measurement unit 62 may also measure the voltage associated with the current generated in the conductor 612.

[0037] (An example of a method for quantifying the target substance in sample 9 using analyzer 100) Next, an example of a method for quantifying the target substance of sample 9 using the analytical device 100 in the first embodiment will be described.

[0038] The same procedure as described above for the detection method is followed, and at least one of the current and voltage generated in the conductor 612 is measured by the measurement unit 62. After measurement by the measurement unit 62, the evaluation unit 43 refers to, for example, the relationship between at least one of the current and voltage measured by the measurement unit 62 and the content of the target substance in the sample 9, which is stored in the information processing device 4, and quantifies the content of the target substance in the sample 9 based on at least one of the current and voltage measured by the measurement unit 62. This makes it easy to quantify the content of the target substance in the sample 9.

[0039] According to this embodiment, the flow path 61 has an insulating main body 611 and a conductor 612 provided in a part of the cross section perpendicular to the flow direction. The main body 611 has a facing portion 614 facing the conductor 612 and includes a measuring unit 62 for measuring at least one of the current and voltage in the conductor 612, and a temperature control unit 63 for generating a temperature difference between the conductor 612 side of the flow path 61 and the facing portion 614 side of the flow path 61. As a result, a temperature difference is generated in the magnetic insulator 91 contained in the sample 9 within the flow path 61. Due to the temperature difference, a spin current flows in the magnetic insulator 91, and this spin current flows into the conductor 612. As a result, a spin Seebeck effect occurs, generating an electric current in the conductor 612. By measuring at least one of the current generated in the conductor 612 and the voltage associated with this current using the measuring unit 62, the presence or absence of a target object in the sample 9 can be detected. As a result, it becomes possible to easily detect the target object in the sample 9.

[0040] According to this embodiment, the system further includes an evaluation unit 43 that quantifies the target object based on at least one of the current and voltage measured by the measurement unit 62. This makes it possible to easily quantify the target object of the sample 9.

[0041] According to this embodiment, the magnet 613 is provided on the conductor 612. This allows the magnetic insulator 91 contained in the sample 9 to be attracted to or adhered to the magnet 613. As a result, the spin current flowing into the conductor 612 can be increased, and the current generated in the conductor 612 can be increased. Therefore, it is possible to further improve the detection accuracy of the target substance contained in the sample 9. Furthermore, when quantifying the target substance, it is possible to further improve the quantitative accuracy of the target substance.

[0042] According to this embodiment, the measurement unit 62 measures at least one of the current and voltage generated in the conductor 612 while the sample 9 is stopped inside the flow path 61. This stabilizes the current generated in the conductor 612. Therefore, it is possible to further improve the detection accuracy of the object to be detected. Furthermore, when quantifying the object to be detected, it is possible to further improve the quantitative accuracy of the object to be detected.

[0043] According to this embodiment, the magnet 613 is an electromagnet 613a. This makes it easy to collect the sample 9, including the magnetic insulator 91 attached to the electromagnet 613a, after the measurement by the measurement unit 62 has been completed. Therefore, it becomes easy to repeatedly detect and quantify the target object.

[0044] According to this embodiment, the temperature control unit 63 includes a Peltier element 64 and a current generator 65 that supplies current to the Peltier element 64, and the opposing portion 614 is provided in contact with the electrode portion (for example, the first electrode portion 641) of the Peltier element 64. As a result, when current is supplied to the Peltier element 64 and the electrode portion absorbs or generates heat, the opposing portion 614 can be efficiently cooled or heated. Therefore, a temperature difference is more likely to occur between the conductor 612 side of the flow path 61 and the opposing portion 614 side of the flow path 61.

[0045] According to this embodiment, sample 9 contains an antigen 93 and an antibody 92. This makes it possible to easily detect the target substance in a biomaterial that exhibits an antigen-antibody reaction.

[0046] In this embodiment, the temperature control unit 63 cools the opposing part 614 side, but in the present invention, the conductor 612 side may be heated. Alternatively, in the present invention, the temperature control unit 63 may cool or heat the opposing part 614 side and cool or heat the conductor 612 side, but not both.

[0047] <Second Embodiment: Analytical Apparatus 100> The analysis device 100 comprises a detection device 6, a measurement unit 62, and an information processing device 4 in the first modified example. The analysis device 100 analyzes a sample 9 containing a magnetic insulator 91.

[0048] <First modified example of detection device 6> As shown in Figures 7 and 8, the temperature control unit 63 controls the temperature of the conductive material 612 side of the flow path 61 to be higher than the temperature of the opposing portion 614 side of the flow path 61, for example, by heating the conductive material 612 side of the flow path 61. This creates a temperature difference between the conductive material 612 side of the flow path 61 and the opposing portion 614 side of the flow path 61.

[0049] As shown in Figures 9(a) and 9(b), the second electrode portion 644 is provided on the conductor 612 side of the flow path 61, spaced apart from the conductor 612. An insulator 646 is provided between the second electrode portion 644 and the conductor 612. This prevents the current generated in the conductor 612 from flowing to the second electrode portion 644 when a spin current flows through the conductor 612. An insulator 646 is also provided between the second electrode portion 644 and the magnet 613.

[0050] Similarly, the third electrode portion 645 is provided on the conductor 612 side of the flow path 61. An insulator 646 is provided between the third electrode portion 645 and the conductor 612. This prevents the current generated in the conductor 612 from flowing to the third electrode portion 645 when a spin current flows through the conductor 612. In addition, an insulator 646 is provided between the third electrode portion 645 and the magnet 613.

[0051] (An example of a method for detecting the target object of sample 9 using detection device 6) Next, an example of a method for detecting the target substance in sample 9 using the detection device 6 will be described. Figure 10 shows an example of a method for detecting the target substance in sample 9 using the detection device 6. Sample 9 contains a magnetic insulator 91. The magnetic insulator 91 contains an antibody 92 and an antigen 93 bound together via a binder. In the following example, the antibody 92 will be used as the target substance.

[0052] As shown in Figure 10(a), the sample 9 is allowed to flow down the channel 61. At this time, the temperature control unit 63 heats the conductor 612 side of the channel 61 so that the temperature on the conductor 612 side of the channel 61 becomes higher than the temperature on the opposite side 614 of the channel 61. This creates a temperature difference between the conductor 612 side of the channel 61 and the opposite side 614 of the channel 61.

[0053] As shown in Figure 10(b), when the sample 9 reaches the conductor 612 and the electromagnet 613a, the flow of the sample 9 is not stopped, but continues to flow through the channel 61. Because a temperature difference is generated between the conductor 612 side of the channel 61 and the opposing side 614 of the channel 61, a temperature difference is also generated in the magnetic insulator 91 contained in the sample 9. Due to the temperature difference, a spin current flows through the magnetic insulator 91, and this spin current flows into the conductor 612. This generates an electric current in the conductor 612, causing the spin Seebeck effect to occur. By measuring at least one of the current generated in the conductor 612 and the voltage associated with this current using the measurement unit 62, the presence or absence of a target object contained in the sample 9 can be detected.

[0054] Since the electromagnet 613a is provided on the conductor 612 side of the flow path 61, the magnetic insulator 91 contained in the sample 9 is attracted to or adheres to the electromagnet 613a. This increases the spin current flowing into the conductor 612, and thus increases the current generated in the conductor 612.

[0055] Furthermore, since the temperature on the conductor 612 side of the channel 61 is higher than the temperature on the opposite side 614 of the channel 61, as the sample 9 flows down, the flow velocity of the sample 9 on the conductor 612 side of the channel 61 becomes faster than the flow velocity of the sample 9 on the opposite side 614 of the channel 61. As a result, the amount of sample 9 flowing down the conductor 612 side of the channel 61 increases relatively. Therefore, the spin current flowing into the conductor 612 can be increased, and the current generated in the conductor 612 can be increased.

[0056] Then, with the sample 9 flowing, the current generated in the conductor 612 is measured by the measurement unit 62. Since the sample 9 contains the antibody 92, which is the target substance for detection, the antibody 92 can be detected as the target substance by the current measured by the measurement unit 62. The measurement unit 62 may also measure the voltage associated with the current generated in the conductor 612.

[0057] When quantifying the target substance, after measurement by the measurement unit 62, the evaluation unit 43 refers to the relationship between at least one of the current and voltage measured by the measurement unit 62 and the content of the target substance in the sample 9, which is stored, for example, in the information processing device 4, and quantifies the content of the target substance in the sample 9 based on at least one of the current and voltage measured by the measurement unit 62. This makes it easy to quantify the content of the target substance in the sample 9.

[0058] In this way, since the measurement is performed while the sample 9 is flowing, the detection and quantification of the target substance in the sample 9 can be accelerated.

[0059] According to this embodiment, the measurement unit 62 measures at least one of the current and voltage generated in the conductor 612 while the sample 9 is flowing down inside the flow path 61. This allows for faster detection and quantification of the target object in the sample 9 by sequentially flowing the sample 9 down the flow path 61. As a result, the target object in the sample 9 can be detected in a shorter time. Furthermore, when quantifying the target object, the quantification of the target object can be done in a shorter time.

[0060] According to this embodiment, the temperature control unit 63 controls the temperature of the conductor 612 side of the flow path 61 to be higher than the temperature of the opposite side 614 of the flow path 61, and the measurement unit 62 measures at least one of the current and voltage generated in the conductor 612 while the sample 9 is flowing down inside the flow path 61. As a result, the flow velocity of the sample 9 on the conductor 612 side of the flow path 61 becomes faster than the flow velocity of the sample 9 on the opposite side 614 of the flow path 61. Relatively, the amount of sample 9 flowing down the conductor 612 side of the flow path 61 increases. Therefore, the spin current flowing into the conductor 612 can be increased, and the current generated in the conductor 612 can also be increased. As a result, it is possible to improve the detection accuracy of the target substance contained in the sample 9. Furthermore, when quantifying the target substance, it is possible to improve the quantification accuracy of the target substance.

[0061] According to this embodiment, the temperature control unit 63 includes a Peltier element 64 and a current generator 65 that supplies current to the Peltier element 64. The conductor 612 is provided spaced apart from the electrode portions of the Peltier element 64 (for example, the second electrode portion 644 and the third electrode portion 645), and an insulator 646 is provided between the conductor 612 and the electrode portions of the Peltier element 64. This prevents the current generated in the conductor 612 from flowing to the electrode portions of the Peltier element 64. As a result, it is possible to improve the measurement accuracy of at least one of the current and voltage measured by the measurement unit 62. Consequently, it is possible to improve the detection accuracy of the target object contained in the sample 9. Furthermore, when quantifying the target object, it is possible to improve the quantitative accuracy of the target object.

[0062] Although some embodiments of this invention have been described above, these embodiments are presented as examples and are not intended to limit the scope of the invention. Furthermore, these embodiments can be combined as appropriate. In addition, this invention can be implemented in various novel forms other than those described above. Therefore, each of the above embodiments can be omitted, replaced, or modified in various ways without departing from the spirit of this invention. Such novel forms and modifications are included in the scope and spirit of this invention, as well as in the claims and equivalents of the claims. [Explanation of Symbols]

[0063] 100: Analyzer 6: Detection device 61: Flow channel 611: Main body 612: Conductor 613: Magnet 613a: Electromagnet 614: Opposite part 62: Measurement Unit 63: Temperature Control Unit 64: Peltier element 641:First electrode part 642: N-type semiconductor 643: P-type semiconductor 644:Second electrode part 645:Third electrode part 646: Insulator 65: Current Generator 66: 1st wiring 67: 2nd wiring 9: Sample 91: Magnetic insulator 92 :Antibody 93 :Antigen

Claims

1. A detection device for detecting a target object in a sample which includes a composite in which a target object is bonded to a magnetic insulator via a binder, The system includes a cylindrical channel for allowing the sample to flow down, The aforementioned flow path is It has an insulating main body and a conductive material provided in a part of the cross-section perpendicular to the direction of flow, The main body portion has a facing portion that faces the conductor, A measuring unit for measuring at least one of the current and voltage in the aforementioned conductor, The system further comprises a temperature control unit that generates a temperature difference between the conductive side of the flow path and the opposing side of the flow path. A detection device characterized by the following.

2. The flow path has a magnet provided on the conductor. The detection device according to claim 1, characterized by the following:

3. The aforementioned magnet is an electromagnet. The detection device according to claim 2, characterized by the following:

4. The measurement unit measures at least one of the current and voltage generated in the conductor while the sample is stopped inside the flow path. The detection device according to claim 1, characterized by the following:

5. The measurement unit measures at least one of the current and voltage generated in the conductor while the sample is flowing down inside the flow path. The detection device according to claim 1, characterized by the following:

6. The temperature control unit controls the temperature of the conductive side of the flow path to be higher than the temperature of the opposing side of the flow path. The detection device according to claim 4, characterized by the following:

7. The temperature control unit comprises a Peltier element and a current generator that supplies current to the Peltier element. The opposing portion is provided in contact with the electrode portion of the Peltier element. The detection device according to claim 1, characterized by the following:

8. The temperature control unit comprises a Peltier element and a current generator that supplies current to the Peltier element. The conductor is provided spaced apart from the electrode portion of the Peltier element. An insulator is provided between the conductor and the electrode portion of the Peltier element. The detection device according to claim 1, characterized by the following:

9. The aforementioned sample contains an antigen and an antibody. The detection device according to claim 1, characterized by the following:

10. An analytical apparatus for analyzing an object to be detected, comprising the detection device described in claim 1, The system further includes an evaluation unit that quantifies the object to be detected based on at least one of the current and voltage measured by the measurement unit. An analytical device characterized by the following.

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