Oil-based emulsions in water

Abstract

To provide an oil-in-water type emulsion composition comprising a heparinoid, which has excellent usability such as non-stickiness and moisturizing effect due to moisture occlusive property, does not drip down when in use and has excellent discharging properties from a container.SOLUTION: There is provided an oil-in-water type emulsion composition which comprises the following components (A) to (D): (A) a heparinoid, (B) 1 to 5 mass% of a polyethylene glycol monostearate, (C) 1 to 10 mass% of a higher alcohol having 12 to 22 carbon atoms, (D) one or two or more selected from the group consisting of a hydrocarbon oil and an ester oil which is in a paste state at 25°C and (E) an oil agent which is liquid at 25°C, wherein the content of the component (D) is 20 mass% or more based on the total amount of the oil agent in the composition.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oil-in-water type emulsion composition.

Background Art

[0002] Heparin analogs, which are polysulfated esters of mucopolysaccharides, have excellent moisturizing, blood circulation promoting, anti-inflammatory, and other effects, and are thus widely used as active ingredients in skin external preparations. In recent years, not only the formulation stability but also the development of heparin analog-containing preparations with excellent usability during application has been actively carried out. For example, an oil-in-water type emulsion composition technology containing a heparin analog, hydrophobized hydroxypropylmethylcellulose, an oil agent, a surfactant, and water, and having a pH of 4.5 to 7.0 at 30°C (see, for example, Patent Document 1) has been studied.

[0003] Among them, since the face, hands, etc., which are constantly exposed to the outside air, are easily rough, there is a demand for the development of cream preparations that have an excellent moisturizing effect due to oil content and are also excellent in portability and usability. Many of these cream preparations are oil-in-water type emulsion compositions, and various effects can be imparted depending on the type of oil agent contained. For example, an oil-in-water type emulsion composition containing an oil agent having a paste-like form can provide a firm feeling and a moisturizing feeling during application. However, in an emulsified preparation containing a high content (for example, 10% by mass or more) of an oil agent having a paste-like form, there may occur problems such as deterioration of stickiness and an increase in viscosity, resulting in a decrease in dischargeability from the container, making it difficult to achieve good usability. As a technology containing a heparin analog and an oil agent having a paste-like form, for example, a technology of an oil-in-water type emulsion composition containing a heparin analog and one or more oil-soluble components selected from the group consisting of oil-soluble acylamino acids, their derivatives, and their salts, and a paste-like oil (see, for example, Patent Document 2) is known.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

[0005] However, while the technology disclosed in Patent Document 1 is excellent in terms of stability and smoothness during application, it sometimes falls short in terms of dripping and dispensing from the container. While the technology disclosed in Patent Document 2 offers excellent usability, such as being non-sticky, it sometimes falls short in terms of moisturizing effect, drip-free properties, and ease of dispensing from the container.

[0006] Cream formulations such as hand creams, body creams, and facial balms are designed for long-term, continuous skin care, regardless of time or location, making portability and ease of use crucial. In particular, in high-temperature summer conditions, there are concerns about instability and dripping due to decreased viscosity, while in low-temperature winter conditions, increased viscosity can lead to reduced dispensing. Therefore, there is a need to develop cream formulations that offer excellent stability and good usability under these various environmental conditions.

[0007] Therefore, the present invention aims to provide an oil-in-water emulsion composition containing a heparin-like substance that is excellent in terms of usability, such as being non-sticky, and moisturizing effect due to its water-occluding properties, and furthermore, does not drip and has excellent discharge properties from the container. [Means for solving the problem]

[0008] The inventors, after diligent research to solve the above problems, discovered that using polyethylene glycol monostearate as a surfactant in an oil-in-water emulsion composition containing a heparin-like substance results in a composition with excellent stability over time and usability, such as a moderate richness and moisturizing effect, which are required for cream formulations. However, when the usability under high and low temperature conditions was confirmed under various usage scenarios, concerns arose regarding dripping at high temperatures and reduced dispensing from containers at low temperatures. As a result of further research, the inventors discovered that by dissolving a specific paste-like oil at a concentration of 20% by mass or more relative to the total amount of oil in a liquid oil, and then emulsifying it with polyethylene glycol monostearate and a specific higher alcohol, an oil-in-water emulsion composition can be obtained that does not drip at high temperatures and also exhibits excellent dispensing from containers at low temperatures. Furthermore, by using the above combination, even when the oil contains 20% by mass or more of a paste-like oil relative to the total amount of oil, it is possible to create an oil-in-water emulsion composition that is non-greasy and has excellent moisturizing effects due to its moisture-blocking properties, and it has been found that this effect is sustained and that a roughness-improving effect can also be obtained, thus completing the present invention.

[0009] The present invention relates to an oil-in-water emulsion composition containing a heparin-like substance. By combining polyethylene glycol monostearate, a higher alcohol having 12 to 22 carbon atoms, one or more substances selected from the group consisting of hydrocarbon oils and ester oils that exhibit a paste-like state at 25°C, and an oil that is liquid at 25°C, and by creating an oil-in-water emulsion composition in which the content of specific components is within a specific range, it has been found that the emulsion does not drip at high temperatures, has excellent discharge properties from containers at low temperatures, and also exhibits excellent non-stickiness and moisturizing effects, thus completing the present invention.

[0010] In other words, the present invention provides the following: [1] The following components (A) to (D); (A) Heparinoid (B) Polyethylene glycol monostearate 1-5% by mass (C) Higher alcohols with 12-22 carbon atoms, 1-10% by mass (D) At 25°C, it exhibits a paste-like consistency and consists of one or more selected from the group comprising hydrocarbon oils and ester oils. (E) Liquid oil at 25°C This is an oil-in-water emulsion composition containing the above component (D) with respect to the total amount of oil in the composition being 20% ​​by mass or more. [2] The oil-in-water emulsion composition described in [1] contains a hydrocarbon oil and an ester oil. [3] The oil-in-water emulsion composition according to [1] or [2], wherein the total content of component (D) and component (E) [(D) + (E)] is 20 to 40% by mass. [4] The oil-in-water emulsion composition according to [1] or [2], wherein the ester oil of component (D) is a sterol fatty acid ester and an N-acyl amino acid sterol ester. [5] The oil-in-water emulsion composition described in [4] is wherein the sterol fatty acid ester of component (D) is one or two selected from phytosteryl oleate and phytosteryl macadamia nut oil fatty acid, and the N-acyl amino acid sterol ester of component (D) is one or more selected from N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl), and N-lauroyl-L-glutamic acid di(phytosteryl / 2-octyldodecyl). [6] The oil-in-water emulsion composition according to [1] or [2] contains, in the above component (E), component (E1) hydrocarbon oil and ester oil. [7] The oil-in-water emulsion composition according to [1] or [2], wherein the mass ratio of hydrocarbon oil to ester oil [hydrocarbon oil / ester oil] in component (D) is 1 to 10.

[0011] Furthermore, this technology can also incorporate the following additional configurations. [8] The oil-in-water type emulsion composition according to [1] or [2], further containing at least one selected from the component (F) cellulose-based water-soluble polysaccharide and hydrophobically modified polyether urethane. [9] The oil-in-water type emulsion composition according to [1] or [2], wherein in the component (E), the component (E2) contains a fatty acid that is liquid at 25°C.

[10] The oil-in-water type emulsion composition according to [1] or [2], which is contained in a tube container.

[11] A cosmetic or a skin external preparation containing the oil-in-water type emulsion composition according to [1] or [2]. [Effects of the Invention]

[0012] In the oil-in-water type emulsion composition containing the heparin-like substance of the present invention, it does not sag even at high temperatures and has excellent dischargeability from the container at low temperatures. Furthermore, it has excellent moisturizing effects due to non-stickiness and moisture-blocking properties. [Modes for Carrying Out the Invention]

[0013] Hereinafter, embodiments of the present invention will be described. The present invention is not limited only to the following embodiments. In this specification, "X~Y" indicating a range includes X and Y and means "X or more and Y or less".

[0014] (Component (A): Heparin-like substance)

[0015] Component (A), the heparin-like substance used in the present invention, is a heparin-like substance defined in the Pharmaceutical Excipients Standard outside the Japanese Pharmacopoeia, and is a polysulfated ester of mucopolysaccharide obtained by sulfating a polysaccharide having a disaccharide composed of D-glucuronic acid and N-acetyl-D-galactosamine as a repeating unit. The heparin-like substance is a component having a chemical structure similar to "heparin", which is a kind of saccharide produced in the human liver, and is generically called a similar substance. Specifically, the heparin-like substance includes cellulose sulfate, chitin sulfate, chitosan sulfate, pectin sulfate, chondroitin sulfate, inulin sulfate, alginic acid sulfate, glycogen sulfate, starch sulfate, polyvinyl alcohol sulfate, polyglucose sulfate, polylactose sulfate, laminarin sulfate, galactan sulfate, levan sulfate, their polysulfates, and their salts. The heparin-like substance is known to have a moisturizing effect and a blood circulation promoting effect. In the present invention, the heparin-like substance described in the Pharmaceutical Excipients Standard outside the Japanese Pharmacopoeia 2002 can be preferably used. The heparin-like substance defined in the Pharmaceutical Excipients Standard outside the Japanese Pharmacopoeia is mainly composed of a polysulfated ester of chondroitin sulfate. The amount of the organic sulfate group of the heparin-like substance is not particularly limited, and any of them can be used, but the preferred amount of the organic sulfate group is preferably 20 to 40% by mass (hereinafter simply abbreviated as %) from the viewpoints of the moisturizing effect and usability. The amount of the organic sulfate group of component (A) in the present invention can be measured by the method described in the quantitative method of "heparin-like substance" in the Pharmaceutical Excipients Standard outside the Japanese Pharmacopoeia 2002.

[0016] The content of component (A) in the present invention is not particularly limited, but in the oil-in-water type emulsion composition, 0.001% or more is preferable, 0.01% or more is more preferable, 0.05% or more is even more preferable, and 0.1% or more is particularly preferable. Also, 5% or less is preferable, 1% or less is more preferable, 0.8% or less is even more preferable, and 0.5% or less is particularly preferable. By setting these ranges, it is more preferable because it is excellent in stickiness and moisturizing effect.

[0017] The content of component (A) in the present invention is not particularly limited, but is preferably 0.001 to 5%, more preferably 0.01 to 1%, even more preferably 0.05 to 0.8%, and particularly preferably 0.1 to 0.5% in the oil-in-water emulsion composition. These ranges are preferable because they provide superior non-stickiness and moisturizing effects.

[0018] (Component (B): Polyethylene glycol monostearate)

[0019] The component (B) polyethylene glycol monostearate used in the present invention is obtained by monoesterifying polyethylene glycol with stearic acid. In the present invention, it provides non-stickiness, moisturizing effect, and non-dripping properties even at high temperatures (hereinafter sometimes simply abbreviated as "non-dripping"), and is not particularly limited as long as it is used in ordinary cosmetics and topical skin preparations.

[0020] Component (B) can have various HLB values ​​depending on the number of moles of polyethylene glycol added. Specifically, examples include polyethylene glycol monostearate (10 E.O.) (HLB 11), polyethylene glycol monostearate (25 E.O.) (HLB 15), polyethylene glycol monostearate (40 E.O.) (HLB 17.5), polyethylene glycol monostearate (55 E.O.) (HLB 18), etc., and one or more of these can be used. In the present invention, from the viewpoint of non-stickiness, moisturizing effect, and non-dripping, HLB values ​​of 12 to 18 are preferred, and HLB values ​​of 15 to 18 are more preferred. In the present invention, it is particularly preferred that one or two selected from polyethylene glycol monostearate (40 E.O.) and polyethylene glycol monostearate (55 E.O.) be used. Such component (A) can be a commercially available product, specifically NIKKOL MYS-40V, MYS-55V (manufactured by Nikko Chemicals Co., Ltd.), etc. Furthermore, when using two or more types, those with an HLB of 11 to 18 can be selected and used. Even if the HLB of each individual component does not fall within the above HLB range, they can be suitably used if the weighted average value of the HLB, weighted by the content, falls within the range of 15 to 18. Here, HLB (Hydphile-Lipophile Balance) in this invention is an index that indicates the balance between hydrophilicity and lipophilicity, and is calculated by the following formula (Equation 1) by Oda, Teramura et al. HLB = "Inorganic value (IV) / Organic value (OV)" × 10 ... (Equation 1) (See Yoshio Koda, "Organic Concept Diagrams - Fundamentals and Applications," pp. 11-17, Sankyo Publishing, 1984)

[0021] The content of component (B) in the oil-in-water emulsion composition is 1% or more, preferably 1.5% or more, and more preferably 1.8% or more. It is also 5% or less, preferably 4% or less, and more preferably 3% or less. These ranges are preferable because they result in superior non-dripping, low-temperature discharge from the container (hereinafter sometimes simply referred to as "dischargeability"), and non-stickiness.

[0022] The content of component (B) in the oil-in-water emulsion composition is 1 to 5%, preferably 1.5 to 4%, more preferably 1.5 to 3%, and even more preferably 1.8 to 3%. These ranges are preferable because they result in superior non-dripping, non-dispensing, and non-stickiness properties.

[0023] (Component (C): Higher alcohols with 12 to 22 carbon atoms)

[0024] The component (C) higher alcohol having 12 to 22 carbon atoms used in the present invention is not particularly limited as long as it is commonly used in cosmetics and topical skin preparations. Examples include cetyl alcohol, stearyl alcohol, behenyl alcohol, and cetostearyl alcohol, and one or more of these can be used. Furthermore, component (C) preferably has 16 to 22 carbon atoms, and more preferably is one or more selected from stearyl alcohol, cetostearyl alcohol, and behenyl alcohol from the viewpoint of drip-free properties and moisturizing effects, and even more preferably is cetostearyl alcohol and / or behenyl alcohol. In the present invention, it is preferable to contain two or more higher alcohols having 12 to 22 carbon atoms so that drip-free properties and discharge properties are favorably exhibited, and it is even more preferable to use cetostearyl alcohol and behenyl alcohol in combination.

[0025] The content of component (C) in the oil-in-water emulsion composition is 1% or more, preferably 3% or more, and more preferably 5% or more. It is also 10% or less, preferably 8% or less, and more preferably 7% or less. These ranges are preferable because they provide superior drip-free properties, discharge properties, and moisturizing effects.

[0026] The content of component (C) in the present invention is 1 to 10% in the oil-in-water emulsion composition, preferably 3 to 8%, and more preferably 5 to 7%. These ranges are preferable because they provide superior drip-free properties, discharge properties, and moisturizing effects.

[0027] (Component (D): One or more components selected from the group consisting of hydrocarbon oils and ester oils, which exhibit a paste-like consistency at 25°C)

[0028] Component (D) used in the present invention is one or more selected from the group consisting of hydrocarbon oils and ester oils, and exhibits a paste-like state at 25°C. Exhibiting a paste-like state at 25°C refers to an oil that has a melting point above 25°C and does not completely solidify below 25°C, thus distinguishing it from liquid oils or solid oils. In the present invention, this refers to an oil with a viscosity of 5,000 to 100,000 mPa·s at 30°C. In the present invention, the viscosity was measured using a single-cylinder rotational viscometer, model VS-A1 (manufactured by Shibaura Systems Co., Ltd.), after leaving the sample at 30°C for one day. The melting point can be defined as the peak top of the highest temperature peak observed in the melting endothermic curve obtained by holding the sample at -10°C in a nitrogen atmosphere for 5 minutes using a differential scanning calorimeter (DSC), and then raising the temperature at 10°C / min.

[0029] Ingredient (D) can be any hydrocarbon oil or ester oil commonly used in cosmetics and topical skin preparations, and any hydrocarbon oil or ester oil that exhibits a paste-like state at 25°C can be used without any particular limitations regarding its molecular weight, degree of esterification, or synthesis method. Specifically as ingredient (D), hydrocarbon oils such as petrolatum, shea butter, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / 2-octyldodecyl), dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / steer Examples of ester oils include bis(behenyl / isostearyl / phytosteryl) dimer dilinoleyl dimer dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, phytosteryl macadamia nut oil fatty acid, cholesteryl macadamia nut oil fatty acid, phytosteryl oleate, cholesteryl oleate, hexa(hydroxystearate / stearate / rosinate)dipentaerythrityl, and cholesteryl hydroxystearate.In this invention, the ester oil is selected from the viewpoint of non-greasyness and moisturizing effect as follows: cholesteryl hydroxystearate, phytosteryl macadamia nut oil fatty acid, cholesteryl macadamia nut oil fatty acid, phytosteryl oleate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl) or N-lauroyl-L-glutamic acid di(phytosteryl / 2-octyldodecyl), dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid It is more preferable to contain one or more selected from dimer dilinoleyl bis(behenyl / isostearyl / phytosteryl) dimer dilinoleate and di(isostearyl / phytosteryl) dimer dilinoleate, and even more preferable to contain one or more selected from macadamia nut oil fatty acid phytosteryl, oleate phytosteryl, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), and N-lauroyl-L-glutamic acid di(phytosteryl / 2-octyldodecyl).

[0030] From the viewpoint of moisturizing effect and other factors, it is preferable that the hydrocarbon oil is petrolatum.

[0031] In the present invention, component (D), which exhibits a paste-like state at 25°C, is preferably a sterol ester, selected from the group consisting of hydrocarbon oils and ester oils, from the viewpoint of drip-free, discharge properties, and moisturizing effect. A sterol ester is an oil having a sterol skeleton and is not particularly limited as long as it is used in ordinary cosmetics and topical skin preparations. In the present invention, it is more preferable that the sterol ester is one or more selected from the group consisting of sterol fatty acid esters (ester derivatives of sterols and fatty acids) and N-acyl amino acid sterol esters (ester derivatives of sterols and acyl amino acids), and even more preferable that it is a sterol fatty acid ester and an N-acyl amino acid sterol ester. Furthermore, cholesterol or phytosterols are particularly preferred as sterols. One or more of these can be used.

[0032] The fatty acid of the sterol fatty acid ester is not limited, but monocarboxylic acids are preferred, more preferably having 2 to 32 carbon atoms, and even more preferably 8 to 22 carbon atoms. The hydrocarbon may be saturated or unsaturated, and may be branched or cyclic. Specifically, examples include acetic acid, butyric acid, caproic acid, caprylic acid, lauric acid, myristic acid, pentadecanoic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, arachidonic acid, behenic acid, and triacontanoic acid. In addition to single-component fatty acids, mixed fatty acids obtained from natural sources such as coconut oil fatty acids, castor oil fatty acids, olive oil fatty acids, palm oil fatty acids, and macadamia nut oil fatty acids, or synthetically obtained fatty acids (including branched fatty acids), may also be used. In the present invention, from the viewpoint of moisturizing effect, etc., it is more preferable that the fatty acid of the sterol fatty acid ester be one or more selected from oleic acid and macadamia nut oil fatty acids.

[0033] Examples of the above-mentioned sterol fatty acid esters include phytosteryl butyrate, phytosteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, phytosteryl isostearate, cholesteryl hydroxystearate, phytosteryl hydroxystearate, phytosteryl caprylate / caprate, phytosteryl ricinoleate, cholesteryl oleate, phytosteryl oleate, dihydrocholesteryl oleate, branched fatty acid (C12-31) cholesteryl, phytosteryl canola oil fatty acid glycerides, phytosteryl rapeseed glycerides, macadamia nut oil fatty acid phytosteryl, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid dihydrocholesteryl, sunflower seed oil fatty acid phytosteryl, rice bran oil fatty acid phytosteryl, lanolin fatty acid cholesteryl, etc. One or more of these can be used. In the present invention, from the viewpoint of moisturizing effect, it is preferable that the sterol fatty acid ester be one or more selected from the group consisting of cholesteryl oleate, phytosteryl oleate, and macadamia nut oil fatty acid phytosteryl, more preferably one or two selected from phytosteryl oleate and macadamia nut oil fatty acid phytosteryl, and particularly preferably macadamia nut oil fatty acid phytosteryl. Examples of commercially available sterol fatty acid esters include PLANDOOL-MAS (manufactured by Nippon Seika Co., Ltd.) and Rysterol Ester (manufactured by Tsukuno Rice Fine Chemicals Co., Ltd.).

[0034] Examples of the aforementioned N-acyl amino acid sterol esters include N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / 2-octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl / isostearyl), and N-myristoyl-N-methyl-β-alanine phytosteryl. In particular, it is preferable that one or more selected from N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / 2-octyldodecyl), and N-lauroyl-L-glutamic acid di(octyldodecyl / phytosteryl / behenyl). The N-acyl amino acid sterol ester may be a mixture of two or more.

[0035] Furthermore, N-lauroyl-L-glutamic acid di(phytosteryl / 2-octyldodecyl) refers to compounds obtained by esterifying the two carboxyl groups of N-lauroyl-L-glutamic acid with phytotholol and 2-octyldodecyl alcohol. Specifically, it includes N-lauroyl-L-glutamic acid diphytosteryl ester, N-lauroyl-L-glutamic acid γ-phytosteryl-α-2-octyldodecyl ester, and N-lauroyl-L-glutamic acid α-phytosteryl-γ-2-octyldodecyl ester. The same applies to N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl).

[0036] Examples of commercially available N-acyl amino acid sterol esters include Eldew CL-301, Eldew CL-202 (both manufactured by Ajinomoto Co., Inc.), Estemol CHS (manufactured by Nisshin Oillio Co., Ltd.), Eldew PS-203, Eldew PS-304, Eldew PS-306, Eldew APS-307 (all manufactured by Ajinomoto Co., Inc.), PLANDOOL-LG1, PLANDOOL-LG2, PLANDOOL-LG3 (all manufactured by Nippon Seika Co., Ltd.), and others. One or more of these can be used.

[0037] The ester oil is not particularly limited as long as it is commonly used in cosmetics and topical skin preparations, but from the viewpoint of preventing dripping, dispensing, and lack of stickiness, it is preferable that the IOB value is 0.1 to 0.5, and more preferably 0.1 to 0.4.

[0038] Here, we will explain the IOB value. The IOB value is a value determined based on the Organic Concept Diagram (Takashi Fujita, Prediction of Organic Compounds and the Organic Concept Diagram, Chemistry Vol. 11, No. 10 (1957) 719-715). More specifically, in this Organic Concept Diagram, the degree of physical properties of a compound is defined as "organic" (mainly due to van der Waals forces) and "inorganic" (mainly due to electrical affinity). The IOB value is an index that shows the balance between inorganic and organic properties, and is expressed as IOB value = inorganic value / organic value. Compounds with a larger IOB value are said to exhibit higher hydrophilicity and polarity.

[0039] The content of component (D) in the present invention is not particularly limited, but it is preferably 5% or more, more preferably 7% or more, and even more preferably 10% or more in the oil-in-water emulsion composition from the viewpoint of not dripping and having excellent moisturizing effect. Furthermore, it is preferably 30% or less, more preferably 25% or less, even more preferably 20% or less, and particularly preferably 15% or less from the viewpoint of not being sticky and having excellent discharge properties.

[0040] The content of component (D) in the present invention is not particularly limited, but is preferably 5 to 25%, more preferably 7 to 20%, and even more preferably 10 to 15% in the oil-in-water emulsion composition. These ranges are preferable because they result in superior drip-free properties, dischargeability, non-stickiness, and moisturizing effect.

[0041] The hydrocarbon oil content of component (D) is not particularly limited, but is preferably 5-20%, more preferably 5-15%, and even more preferably 7-15% in the oil-in-water emulsion composition. These ranges are preferable because they provide superior performance in terms of drip resistance and moisturizing effect. Furthermore, the hydrocarbon content relative to the total amount of component (D) is preferably 60-90%, and more preferably 70-80%. These ranges are preferable because they provide superior performance in terms of drip resistance, dispensability, non-stickiness, and moisturizing effect.

[0042] The ester oil content of component (D) is not particularly limited, but is preferably 1-10%, more preferably 2-6%, and even more preferably 2-5% in the oil-in-water emulsion composition. These ranges are preferable because they provide superior performance in terms of drip-free properties, dischargeability, and non-stickiness. Furthermore, the ester oil content relative to the total amount of component (D) is preferably 10-40%, more preferably 15-35%, and even more preferably 20-30%. Within this range, it is preferable because it provides superior performance in terms of drip-free properties, dischargeability, non-stickiness, and moisturizing effect.

[0043] In the present invention, it is particularly preferable that component (D) contains hydrocarbon oil and ester oil in order to exhibit excellent drip-free and discharge properties, as well as non-stickiness and a suitable moisturizing effect. The mass ratio of hydrocarbon oil and ester oil is not particularly limited, but the mass ratio [hydrocarbon oil / ester oil] is preferably 1 to 10, more preferably 1 to 5, even more preferably 2 to 5, and particularly preferably 2.5 to 5.

[0044] In the present invention, the content of component (D) relative to the total amount of oil in the oil-in-water emulsion composition (hereinafter sometimes simply referred to as "content of component (D) relative to the total amount of oil") is important in order to exhibit non-stickiness and moisturizing effects while also improving drip-free and discharge properties. In the present invention, the content of component (D) relative to the total amount of oil is 20% or more, preferably 30% or more, and more preferably 35% or more. Furthermore, the content of component (D) relative to the total amount of oil is preferably 60% or less, more preferably 55% or less, and even more preferably 50% or less. These ranges are preferable because they allow for more favorable performance of drip-free and discharge properties.

[0045] (Component (E): Liquid oil at 25°C)

[0046] The component (E) liquid oil at 25°C used in the present invention (hereinafter sometimes simply referred to as "liquid oil") refers to an oil that has a melting point at a temperature of 25°C or lower and is fluid at 25°C, and is distinguished from paste oils. It is not particularly limited as long as it is used in ordinary cosmetics and topical skin preparations. For example, regardless of whether it is volatile or non-volatile, or of origin such as animal oil, vegetable oil, or synthetic oil, examples include hydrocarbons, fats and oils, ester oils including UV absorbers, fatty acids, higher alcohols, silicone oils, fluorinated oils, lanolin derivatives, etc., and is not limited to these. One or more of these can be appropriately selected and used.

[0047] Specifically, the aforementioned component (E) includes vegetable oils such as olive oil, castor oil, mink oil, macadamia nut oil, avocado oil, and meadowfoam oil; jojoba oil, diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol di-2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, and tri-2-ethyl Trimethylolpropane tetrahexanoate, pentaerythritol tetra-2-ethylhexanoate, cetyl 2-ethylhexanoate, ethyl oleate, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, triethyl citrate, 2-ethylhexyl succinate, isocetyl stearate, butyl stearate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate Tylhexyl, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, dipentaerythritol fatty acid ester, isononyl isononanoate, isotridecyl isononanoate, isopropyl myristate, isopropyl palmitate, 2-octyldodecyl myristate, 2-hexyldecyl myristate, myristyl myristate, hexyldecyl dimethyloctanoate, ethyl laurate, hexyl laurate, 2-ethylhexyl methoxycinnamate, diisostearyl malate, tri2 - Ester oils such as glyceryl ethylhexanoate, glyceryl tri(caprylate / caprine), glyceryl tricaprate, glyceryl triisostearate, diglyceryl diisostearate, diglyceryl triisostearate, diglyceryl tetraisostearate, decaglyceryl decaisostearate, glyceryl triisopalmitate, glyceryl trimyristicate, diglyceryl isostearate myristate, tridecyl trimelliticate, etc.; fatty acids such as isostearic acid and oleic acid;Examples of oils include silicone oils such as low-molecular-weight dimethylpolysiloxane, high-molecular-weight dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, and fluorine-modified organopolysiloxane; fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether; hydrocarbon oils such as isododecane, isohexadecane, mineral oil, hydrogenated polyisobutene, squalane, α-olefin oligomer, and polybutene; higher alcohols such as oleyl alcohol, isostearyl alcohol, octyldodecanol, and decyltetradecanol; and lanolin derivatives such as lanolin acetate, isopropyl lanolin fatty acid, and lanolin alcohol. One or more of these can be appropriately selected and used.

[0048] In the present invention, component (E) is preferably one or more selected from hydrocarbon oils and ester oils, in order to improve the solubility of component (D), prevent dripping, and exhibit suitable discharge properties and non-stickiness.

[0049] The hydrocarbon oil of component (E1) is not particularly limited as long as it is commonly used in cosmetics and topical skin preparations, but specifically, examples include isododecane, isohexadecane, mineral oil, hydrogenated polyisobutene, squalane, etc., and squalane and / or mineral oil are more preferable because they exhibit desirable properties such as non-dripping, non-dispensing, and non-stickiness.

[0050] The ester oil of component (E1) is not particularly limited as long as it is commonly used in cosmetics and topical skin preparations, but from the viewpoint of non-dripping, easy dispensing, and non-stickiness, it is preferable that the IOB value is 0.1 to 0.5, and more preferably 0.1 to 0.4. Specifically, examples include glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, ethyl oleate, etc., and it is preferable that it contains at least pentaerythritol tetra-2-ethylhexanoate.

[0051] The content of component (E) in the present invention is not particularly limited, but it is preferably 5% or more, more preferably 10% or more, and even more preferably 15% or more in the oil-in-water emulsion composition. Furthermore, it is preferably 30% or less, more preferably 25% or less, and even more preferably 20% or less. These ranges are preferable because they result in better drip-free, non-dischargeable, and non-sticky properties.

[0052] The content of component (E) in the present invention is not particularly limited, but is preferably 5 to 30%, more preferably 10 to 25%, even more preferably 10 to 20%, and particularly preferably 15 to 20% in the oil-in-water emulsion composition. These ranges are preferable because they result in better drip-free, non-dispensable, and non-sticky properties.

[0053] In the present invention, the content of component (E1) relative to the total amount of component (E) is not particularly limited, but is preferably 70-100%, more preferably 80-100%, even more preferably 90-100%, and particularly preferably 90-95%. These ranges are preferable because they result in better non-dripping, non-dispensing, and non-stickiness properties.

[0054] The hydrocarbon oil content relative to the total amount of component (E1) is not particularly limited, but is preferably 20-60%, more preferably 30-50%, and even more preferably 40-50%. By setting it within these ranges, the solubility of component (D) is improved, resulting in good drip-free, discharge-free, and non-sticky properties.

[0055] The content of ester oil relative to the total amount of component (E1) is not particularly limited, but is preferably 30-70%, more preferably 40-60%, and even more preferably 50-60%. By setting it within these ranges, the solubility of component (D) is improved, resulting in good drip-free, non-dispensable, and non-sticky properties.

[0056] Furthermore, in component (E) of the present invention, it is particularly preferable to include component (E1) hydrocarbon oil and ester oil, from the viewpoint of improving the solubility of component (D) and providing excellent non-stickiness. The mass ratio of the components is not particularly limited, but specifying the mass ratio is preferable because it allows the effects of the present invention to be suitably exhibited. The mass ratio of hydrocarbon oil and ester oil [ester oil / hydrocarbon oil] is preferably 0.5 to 3, more preferably 0.8 to 2, even more preferably 1 to 1.5, and particularly preferably 1 to 1.3.

[0057] Furthermore, in component (E) of the present invention, it is preferable to include a fatty acid that is liquid at 25°C in component (E2), as this allows for favorable dispensability and non-stickiness. Component (E2) is not particularly limited as long as it is commonly used in cosmetics and topical skin preparations, but isostearic acid and / or oleic acid is preferred, with isostearic acid being more preferred. Commercially available products include Isostearic Acid EX (manufactured by Higher Alcohol Industry Co., Ltd.) and NAA-400 Oleic Acid (manufactured by NOF Corporation).

[0058] In the present invention, the content of component (E2) relative to the total amount of component (E) is not particularly limited, but is preferably 1 to 10%, more preferably 1 to 8%, and even more preferably 3 to 6%. These ranges are preferable because they allow for favorable dispensability, non-stickiness, and moisturizing effect.

[0059] In the present invention, the total content of component (D) and component (E) [(D) + (E)] in the oil-in-water emulsion composition is preferably 20-40%, more preferably 25-40%, and even more preferably 25-35%. These ranges are preferable because they result in superior non-stickiness and discharge properties.

[0060] (Component (F): At least one or more selected from cellulose-based water-soluble polysaccharides and hydrophobic modified polyether urethanes)

[0061] In the present invention, it is preferable to further include at least one or more components selected from cellulose-based water-soluble polysaccharides and hydrophobic modified polyether urethanes as component (F), as this effectively prevents dripping and stickiness.

[0062] The aforementioned cellulose-based water-soluble polysaccharides are not particularly limited as long as they are commonly used in cosmetics and topical skin preparations. Specifically, examples include methylcellulose, hydroxypropyl methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, cationic hydroxyethylcellulose, hydrophobic modified hydroxyethylcellulose, or cationic hydrophobic modified hydroxyethylcellulose. Furthermore, if carboxymethylcellulose contains a salt, the salt is not particularly limited. Preferred examples of carboxymethylcellulose salts include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, organic amine salts such as ammonium, triethanolamine, and triethylamine, and basic amino acid salts such as lysine and arginine. One or more types of cellulose-based water-soluble polysaccharides can be used. These are not particularly limited by their origin, such as natural or synthetic.

[0063] Of these, in the present invention, hydroxyethylcellulose, cellulose gum, and hydroxypropyl methylcellulose are preferred from the viewpoint of not dripping or stickiness, and hydroxyethylcellulose is more preferred. Examples of commercially available hydroxyethylcellulose include NATROSOL250HHR (manufactured by ASHLAND SPECIALTY INGREDIENTS).

[0064] The aforementioned hydrophobic modified polyether urethane is an amphiphilic copolymer with a hydrophilic base as its backbone and hydrophobic moieties at its ends. In an aqueous medium, the hydrophobic moieties of the copolymer associate with each other, exhibiting a thickening effect as an associative thickener, and is represented by the following general formula (2): R1─{(O─R2)k─OCONH─R3[─NHCOO─(R4─O)n─R5]h}m (2)

[0065] In formula (2) above, R1, R2, and R4 represent hydrocarbon groups that may be the same or different from each other, R3 represents a hydrocarbon group that may have a urethane bond, R5 represents a linear, branched, or secondary hydrocarbon group, m is a number of 2 or more, h is a number of 1 or more, and k and n are independently numbers in the range of 0 to 1000. Preferably, the number of carbon atoms in R1, R2, and R4 is 2 to 4, the number of carbon atoms in R3 is 1 to 30, and the number of carbon atoms in R5 is 8 to 36. Also, m is preferably 2, h is preferably 1, k is preferably 1 to 500, and more preferably 100 to 300. Also, n is preferably 1 to 200, and more preferably 10 to 100.

[0066] The hydrophobic modified polyether urethane represented by the above general formula (2) can be obtained, for example, by reacting one or more polyether polyols represented by R1-[(O-R2)k-OH]m with one or more polyisocyanates represented by R3-(NCO)h+1 and one or more polyether monoalcohols represented by HO-(R4-O)n-R5.

[0067] In this case, R1 to R5 in general formula (2) are determined by the R1-[(O-R2)k-OH]m, R3-(NCO)h+1, and HO-(R4-O)n-R5 used. The charging ratio of the three is not particularly limited, but it is preferable that the ratio of hydroxyl groups derived from the polyether polyol and polyether monoalcohol to isocyanate groups derived from the polyisocyanate is NCO / OH = 0.8:1 to 1.4:1.

[0068] Among these, in the present invention, from the viewpoint of drip-free and discharge properties, a structure having polyethylene glycol modified at both ends with decyltetradecyl alcohol and having an average weight molecular weight of about 50,000 (GPC method) is preferred. Examples of commercially available hydrophobic modified polyether urethanes include "Adekanol GT-700" (manufactured by ADEKA Corporation), which is a PEG-240 / decyltetradeceth-20 / hexamethylene diisocyanate copolymer.

[0069] In the present invention, it is particularly preferable to use a combination of a cellulose-based water-soluble polysaccharide and a hydrophobic modified polyether urethane as component (F) because these components exhibit desirable properties such as non-dripping, non-stickiness, and moisturizing effects.

[0070] The content of component (F) in the present invention is not particularly limited, but it is preferably 0.005 to 0.5%, more preferably 0.01 to 0.2%, and even more preferably 0.05 to 0.2% in the oil-in-water emulsion composition. These ranges are preferable because they allow for good drip-free and discharge properties while suitably exhibiting non-stickiness and moisturizing effects.

[0071] The content of the aforementioned cellulose-based water-soluble polysaccharide is not particularly limited, but is preferably 0.01 to 0.5%, more preferably 0.02 to 0.2%, and even more preferably 0.05 to 0.2% in the oil-in-water emulsion composition. These ranges are preferable because they result in better performance in terms of preventing dripping and stickiness.

[0072] The content of the hydrophobic modified polyether urethane is not particularly limited, but is preferably 0.005 to 0.1%, more preferably 0.005 to 0.05%, and even more preferably 0.005 to 0.01% in the oil-in-water emulsion composition. These ranges are preferable because they result in better drip-free properties, discharge properties, and moisturizing effects.

[0073] In addition to the above components (A) to (F), the oil-in-water emulsion composition of the present invention may appropriately contain, as long as it does not impair the effects of the present invention, water and aqueous components such as polyhydric alcohols and lower alcohols, or components commonly used in emulsion compositions, as components constituting the aqueous phase. For example, surfactants other than component (B), emulsifying aids other than component (C), oils other than components (D) and (E), water-soluble polymers other than component (F), powders, anti-fading agents, antioxidants, preservatives, cosmetic ingredients other than component (A), fragrances, etc., may appropriately contain, as long as it does not impair the effects of the present invention. In the oil-in-water emulsion composition of the present invention, the content of aqueous components in the oil-in-water emulsion composition is preferably 50 to 80%, more preferably 50 to 70% or more, and even more preferably 55 to 70%.

[0074] Here, the aqueous component can be any water or any water-soluble component. Examples of water-soluble components include glycols such as propylene glycol, 1,3-butylene glycol, dipropylene glycol, and polyethylene glycol; glycerols such as glycerin, diglycerin, and polyglycerin; sugar alcohols such as sorbitol, maltitol, and glucose; and lower alcohols such as ethanol. The water is not particularly limited as long as it is commonly used in cosmetics, etc., but examples include purified water, hot spring water, ion-exchanged water, deep sea water, tap water, or steam-distilled water from plants, and one or more types can be appropriately selected and used as needed.

[0075] As for the oils, any oil other than components (D) and (E) that is commonly used in cosmetics and topical skin preparations can be used, regardless of origin (animal oil, synthetic oil, etc.) or properties (semi-solid oil, liquid oil, solid oil, volatile oil, non-volatile oil, etc.), including hydrocarbon oils, silicone oils, fluorinated oils, and lanolin derivatives.

[0076] The beauty ingredients include active ingredients such as whitening agents, anti-wrinkle agents, and anti-inflammatory agents. In recent years, there has been a growing consumer demand for even greater beauty effects, leading to a need for product development that combines multiple active ingredients. In the present invention, in addition to component (A) heparinoid, it is preferable to further include an anti-inflammatory agent. The anti-inflammatory agent is preferably glycyrrhizic acid, glycyrrhetinic acid, or their derivatives, and more preferably stearyl glycyrrhetinate. The content of the anti-inflammatory agent is not particularly limited, but it is preferably 0.001 to 3%, more preferably 0.01 to 1%, even more preferably 0.06 to 0.5%, and particularly preferably 0.1 to 0.4% in the oil-in-water emulsion composition. Within this range, it is preferable because it can exert its effect as an active ingredient without impairing the effects of the present invention.

[0077] The oil-in-water emulsion composition of the present invention can be implemented in various forms, such as gel, cream, and mousse, with a cream form being preferable for obtaining the effects of the present invention. Here, "cream form" refers to a consistency value of 250 or less at 30°C, and this consistency value is measured 5 seconds after dropping using a 30g aluminum cone in accordance with JIS-K-2220.

[0078] The oil-in-water emulsion composition of the present invention may be used as is as the final formulation, or it may be used as part of a final formulation mixed with other components. Here, the final formulation is not particularly limited as long as it is applied to the skin. Specifically, it may be in any form such as a topical skin preparation, a cosmetic, or a skin cleanser, and is preferably a cosmetic or a topical skin preparation.

[0079] The oil-in-water emulsion composition of the present invention can be used in cosmetics. For example, it is suitable for lotions, creams, serums, massage cosmetics, hand creams, body creams, balms, makeup cosmetics, makeup bases, eye creams, sunscreens, hair creams, hair waxes, etc. Skin care cosmetics are preferred in terms of the ability to feel the effects, and eye creams, balms, massage cosmetics, hand creams, body creams, etc. are particularly preferred from the viewpoint of exhibiting the effects of the present invention effectively.

[0080] The oil-in-water emulsion composition of the present invention can also be used as a topical skin preparation. Examples include topical gels, creams, ointments, liniments, and plasters. The method of use is the same as that for the cosmetic composition described above.

[0081] Oil-in-water emulsion compositions are provided to consumers in various containers such as bottles, jars, and tubes. The oil-in-water emulsion composition of the present invention exhibits excellent drip-free and discharge properties, and to optimally demonstrate this effect, it is preferable to house it in a tube container. In this case, a series of actions is essential: a certain amount is discharged when an appropriate load is applied to the tube container by pressing, etc., and discharge stops when the load is released. Generally, if the viscosity of the composition housed inside the container is too high, it becomes difficult to press, requiring excessive force to discharge, which reduces usability and is undesirable. Conversely, if the viscosity is too low, an excessive amount of the composition is discharged when pressed, and it also drips from the hand during discharge, reducing usability. It is preferable that it can be used appropriately under the temperature conditions that users normally use. However, whether an oil-in-water emulsion composition discharges from a tube container without dripping depends on various factors other than viscosity, such as the shape of the container and the ease of applying load, and selecting the appropriate one is not easy, requiring experiments under multiple conditions. Furthermore, especially in cosmetics, aesthetic and other subjective choices are made, which is largely different from mere design considerations. Furthermore, since oil-in-water emulsion compositions are non-Newtonian fluids, it is difficult to predict their discharge properties from a container based solely on their viscosity. In this study, we found that by combining components (A) to (E) and controlling the content of each component, as well as the content of component (D) in the oil, we could achieve a highly user-friendly emulsion that met the seemingly contradictory requirements of having a non-dripping consistency while maintaining excellent discharge properties. This property proved to be particularly important for tube containers.

[0082] Any container that can hold an oil-in-water emulsion composition can be used as a tube container. Typically, it comprises a container body and a cap, with the container body having a discharge port and a main body. The main body is formed by fusing one end of a cylindrical shape, and the other end of the main body is continuous with the outer edge of a shoulder portion, which has a discharge port protruding from its center. Typically, the main body of the container has a multilayer structure, and the oil-in-water emulsion composition can be filled from the cylindrical end and fused together by heating the end to accommodate it. From the viewpoint of ensuring ease of fusing one end of the main body of the container, the innermost layer of the container is made of polyethylene, preferably low-density polyethylene, and more preferably linear low-density polyethylene. Other layers include metallic layers such as aluminum, and synthetic resin layers such as polypropylene and polyethylene terephthalate.

[0083] Furthermore, while the body of the tube container is not particularly limited, from the viewpoint of ease of pressing, the circumference of the body is preferably 5 to 12 cm, and the total length of the body is preferably 5 to 15 cm. In addition, when the oil-in-water emulsion composition of the present invention is contained in the tube container, the filling amount is preferably 60 to 85% of the storage volume, for example, 40 g when the circumference of the body is 8 cm and the total length of the body is 12 cm. Furthermore, the inner diameter of the discharge port, which affects pressing, is preferably 5 mm.

[0084] (Manufacturing method) The method for producing the oil-in-water emulsion composition of the present invention is not particularly limited and can be produced by commonly known methods, specifically including dispersion emulsification, phase inversion emulsification, and phase inversion temperature emulsification. Any general dispersion and emulsification equipment, such as a dispersion machine, can be used as the production equipment. For example, an oil-in-water emulsion composition can be obtained by adding an aqueous phase heated to 70-80°C to an oil phase in which components (B) to (E) are heated and dissolved at 70-80°C, emulsifying and mixing by dispersion, cooling, and then adding and mixing components (A) and (F).

[0085] Furthermore, the present invention may also employ the following configuration. <1> The following components (A) to (D); (A) Heparinoid (B) Polyethylene glycol monostearate 1-5% by mass (C) Higher alcohols with 12-22 carbon atoms, 1-10% by mass (D) At 25°C, it exhibits a paste-like consistency and consists of one or more selected from the group comprising hydrocarbon oils and ester oils. (E) Liquid oil at 25°C This is an oil-in-water emulsion composition containing the above component (D) with respect to the total amount of oil in the composition being 20% ​​by mass or more. <2> The oil-in-water emulsion composition described in <1> contains a hydrocarbon oil and an ester oil. <3> The oil-in-water emulsion composition according to <1> or <2>, wherein the total content of component (D) and component (E) [(D) + (E)] is 20 to 40% by mass. <4> The oil-in-water emulsion composition according to any one of <1> to <3>, wherein the ester oil of component (D) is a sterol fatty acid ester and an N-acyl amino acid sterol ester. <5> The oil-in-water emulsion composition according to <4> is wherein the sterol fatty acid ester of component (D) is one or two selected from phytosteryl oleate and phytosteryl macadamia nut oil fatty acid, and the N-acyl amino acid sterol ester of component (D) is one or more selected from N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl), and N-lauroyl-L-glutamic acid di(phytosteryl / 2-octyldodecyl). <6> The oil-in-water emulsion composition according to any one of <1> to <5> contains component (E) as component (E1) hydrocarbon oil and ester oil. <7> The oil-in-water emulsion composition according to any one of <1> to <6>, wherein the mass ratio of hydrocarbon oil to ester oil [hydrocarbon oil / ester oil] in component (D) is 1 to 10. <8> A cosmetic or topical skin preparation containing the oil-in-water emulsion composition described in any one of (1) to (7). [Examples]

[0086] The effects of the present invention will be explained using the following examples and comparative examples. However, the technical scope of the present invention is not limited to the following examples.

[0087] Examples 1-17 and Comparative Products 1-7: Oil-in-Water Emulsifier Compositions Oil-in-water emulsion compositions with the compositions shown in Tables 1 and 2 were prepared by the following manufacturing method, and evaluated for the following items: (a) dripping at high temperatures, (b) dischargeability at low temperatures, (c) non-stickiness, and (d) moisturizing effect, according to the evaluation method and judgment criteria shown below. The results are also shown in Tables 1 and 2.

[0088] [Table 1]

[0089] [Table 2]

[0090] Note 1: NIKKOL MYS-40V (manufactured by Nippon Surfactant Industry Co., Ltd.) Note 2: NIKKOL MYS-55V (manufactured by Nippon Surfactant Industry Co., Ltd.) Note 3: Eldew CL-301 (manufactured by Ajinomoto Co., Inc.) Note 4: Eldew PS-203 (manufactured by Ajinomoto Co., Inc.) Note 5: Eldew PS-304 (manufactured by Ajinomoto Co., Inc.) Note 6: PLANDOOL-MAS (manufactured by Nippon Seika Co., Ltd.) Note 7: SNOW WHITE SPECIAL (manufactured by SONNEBORN) Note 8: CETIOL PEEH4 (manufactured by BASF) Note 9: Isostearate EX (Higher Alcohol Industrial Co., Ltd.) Note 10: Natrozole 250HHR (manufactured by Harkless) Note 11: Adekanol GT-700 (manufactured by ADEKA)

[0091] (Manufacturing method) A: Dissolve components (1), (17) to (19) uniformly at 75°C. B: Dissolve components (2) to (16) uniformly at 75°C. C: Gradually add B to A and emulsify using a Despa mixer. D:C was cooled to room temperature to obtain an oil-in-water emulsion composition.

[0092] (Evaluation Method 1) (I: Dripping at high temperatures) Regarding dripping at high temperatures, 15g of each composition was filled into a tube container (capacity: 20ml) with a hole diameter (inner diameter) of 5mm, sealed, and then left to stand in a 40°C constant temperature bath for 1 hour in an upright position (tube opening facing vertically downwards). The amount of dripping (g) of the composition was measured after returning to the upright position and judged according to the following criteria.

[0093] Judgment criteria: [Judgment]: [Amount of sample that dripped] ◎(Excellent): No dripping or dripping. ○ (Good): Less than 5.0g of dripping sauce. × (Not allowed): Drip amount is 5.0g or more

[0094] (Evaluation Method 2) (b: Discharge performance at low temperatures) Regarding dispensing performance at low temperatures, a panel of 20 cosmetic evaluation specialists assigned a 5-point rating according to the evaluation criteria below. The average score from all panel members was then used to determine the final evaluation according to the following criteria. Each composition was filled into a 5mm inner diameter tube container (capacity: 20ml), sealed, and then left upright in a 5°C constant temperature bath for 24 hours. A comparison was then made between a sample left at 25°C for the same period, and the dispensing performance was evaluated accordingly.

[0095] [Rating]:[Evaluation Result] 5 points: very good 4 points: Good 3 points: normal 2 points: Slightly poor 1 point: Defective

[0096] Judgment criteria: [Judgment]: [Average score of the ratings] ◎ (Excellent): Above 4.0 ○ (Good): Above 3.0 and below 4.0 △ (Somewhat unacceptable): Greater than 2.0 and 3.0 or less. × (not possible): 2.0 or less

[0097] (Evaluation Method 3) (a: Non-greasy), (b: Moisturizing effect) Regarding non-greasy feel and moisturizing effect, 20 cosmetic evaluation panel members applied 1g of each composition to their entire face after washing their face. They then rated the non-greasy feel during use and the moisturizing effect after use on a 5-point scale according to the evaluation criteria below. The average score of all panel members was then used to determine the final result according to the following criteria. Non-greasy feel was evaluated from the perspective of whether or not the product felt greasy when applied to the skin, and moisturizing effect was evaluated from the perspective of the skin's moisture level, dryness, and lack of roughness over time.

[0098] [Rating]:[Evaluation Result] 5 points: very good 4 points: Good 3 points: normal 2 points: Slightly poor 1 point: Defective

[0099] Judgment criteria: [Judgment]: [Average score of the ratings] ◎ (Excellent): Above 4.0 ○ (Good): Above 3.0 and below 4.0 △ (Somewhat unacceptable): Greater than 2.0 and 3.0 or less. × (not possible): 2.0 or less

[0100] As is clear from the results in Tables 1-2, Examples 1-17 were superior to Comparative Examples 1-7 in terms of drip-free performance at high temperatures, dispensability at low temperatures, lack of stickiness, and moisturizing effect. On the other hand, Comparative Example 1, which contained less than 1% of component (B) polyethylene glycol monostearate, showed dripping at high temperatures, and Comparative Example 2, which contained more than 5% of component (B), became sticky and its usability was unsatisfactory. Comparative Example 3, which contained less than 1% of component (C) higher alcohol with 12 to 22 carbon atoms, showed unsatisfactory dripping at high temperatures and moisturizing effect. In contrast, Comparative Example 4, which contained more than 10% of component (C), showed significantly worse dispensability at low temperatures. Furthermore, Comparative Example 5, in which the content of component (D) relative to the total amount of oil was less than 20%, showed dripping at high temperatures and also had an inferior moisturizing effect. In addition, Comparative Examples 6 and 7, which used a general-purpose nonionic surfactant instead of component (B), did not yield satisfactory results regarding dripping at high temperatures, lack of stickiness, and moisturizing effect.

[0101] Example 18: Cream (Oil-in-Water Type) (Formulation) [Mass %] 1. Heparin-like substance 2.0 2. Polyethylene glycol monostearate (40 E.O.) Note 1 2.0 3. Cetostearyl alcohol 5.0 4. Behenyl alcohol 5.0 5. Phytosteryl oleate (Note 12) 3.0 6. Vaseline Note 7 8.0 7. Liquid paraffin 3.0 8. Cetyl 2-ethylhexanoate 6.0 9. Squalane 5.0 10. Purified water remaining amount 11. Acrylic acid / alkyl methacrylate copolymer Note 13 0.2 12. (Sodium Acrylate / Sodium Acryloyldimethyl Taurate) Copolymer Note 14 0.2 13. Hydroxyethylcellulose Note 10 0.1 14. 1,3-Butylene glycol 15 15. Glycerin 5.0 16. Sodium hydroxide 0.05 17. Ethanol 5.0 18. Phenoxyethanol 0.5 19. Fragrance 0.1 20. Glycine 0.1 21. N-acetyl-L-hydroxyproline 0.1 22. L-Threonine 0.1 Note 12: Rysterol ester (manufactured by Tsukuno Rice Fine Chemicals Co., Ltd.) Note 13: CARBOPOL 1382 (manufactured by LUBRIZOL ADVANCED MATERIALS) Note 14: SIMULGEL EG QD (manufactured by SEPPIC)

[0102] (Manufacturing method) A: Dissolve components (1), (10) to (14) uniformly at 75°C. B: Dissolve components (2) to (9) uniformly at 75°C. C: Gradually add B to A and emulsify using a Despa mixer. Ingredients (15) to (22) were added to D:C and mixed, and the mixture was filled into a jar container to obtain a cream (oil-in-water type).

[0103] The cream (oil-in-water type) of Example 18 exhibited excellent properties in terms of drip-free operation at high temperatures, dispensability at low temperatures, non-stickiness, and moisturizing effect. Furthermore, the content of component (D) relative to the total amount of oil was 44%. Drip-free operation and dispensability in a jar container were evaluated using the following method. Dripping at high temperatures was determined by filling 15g of the cream from Example 18 into a jar container (capacity: 20ml), letting it stand under the conditions described above, and then observing whether or not dripping occurred when the container was tilted at a 30-degree angle. Dispensability at low temperatures was evaluated by filling 15g of the cream from Example 18 into a jar container (capacity: 20ml) and leaving it to stand in a constant temperature bath at 5°C for 24 hours, and then leaving it to stand at 25°C for the same period. The ease with which the cream could be picked up with a finger was used as the measure of dispensability, and it was evaluated according to the judgment criteria described above.

[0104] Example 19: Emulsion (oil-in-water type) (Formulation) [Mass %] 1. Heparin-like substance 2.0 2. Polyethylene glycol monostearate (40 E.O.) Note 1 2.0 3. Cetostearyl alcohol 3.0 4. Behenyl alcohol 3.0 5. Macadamia nut oil fatty acid phytosteryl Note 6 2.0 6. Vaseline Note 7 5.0 7. Liquid paraffin 5.0 8. Glyceryl tri-2-ethylhexanoate 5.0 9. Purified water remaining amount 10. Carboxyvinyl polymer Note 15 0.1 11. Carrageenan Note 16 0.05 12. Hydroxyethylcellulose Note 10 0.1 13. Dipotassium glycyrrhizinate 0.2 14. 1,3-Butylene glycol 10 15. Glycerin 3.0 16. Polyoxyethylene glycerin (26E.O.) Note 17 2.0 17. Sodium hydroxide 0.05 18. Methylparaben 0.1 19. Ethanol 10 Note 15: CARBOPOL 980 (manufactured by LUBRIZOL ADVANCED MATERIALS) Note 16: Carrageenan J (manufactured by Asahi Chemical Industry Co., Ltd.) Note 17: LIPONIC EG-1 (manufactured by LIPO CHEMICALS)

[0105] (Manufacturing method) A: Dissolve components (1), (9) to (16) uniformly at 75°C. B: Dissolve components (2) to (8) uniformly at 75°C. C: Gradually add B to A and emulsify using a Despa mixer. Components (17) to (19) were added to D:C and mixed, and the mixture was filled into a tube container to obtain an emulsion (oil-in-water type).

[0106] The emulsion (oil-in-water type) of Example 19 exhibited excellent properties in terms of non-drip at high temperatures, dispensability at low temperatures, non-stickiness, and moisturizing effect. Furthermore, the content of component (D) relative to the total amount of oil was 41%.

[0107] Example 20: Hand cream (oil-in-water type) (Formulation) [Mass %] 1. Heparin-like substance 2.0 2. Polyethylene glycol monostearate (40 E.O.) Note 1 2.0 3. Cetostearyl alcohol 1.0 4. Behenyl alcohol 1.0 5. (Sodium acrylate / sodium acryloyldimethyl taurate) copolymer Note 14 0.5 6. Hydrogenated coconut oil Note 18 3.0 7. Vaseline Note 7 4.0 8. Phytosteryl oleate (Note 12) 1.0 9. Cetyl 2-ethylhexanoate 5.0 10. Meadowfoam oil 3.0 11. Purified water remaining amount 12. Acrylic acid / alkyl methacrylate copolymer Note 13 0.1 13. 1,3-Butylene glycol 10 14. Glycerin 5.0 15. Sodium hydroxide 0.02 16. Ethanol 5.0 17. Phenoxyethanol 0.5 18. Fragrance 0.05 Note 18: Super Nucore H (94% purity, manufactured by NOF Corporation)

[0108] (Manufacturing method) A: Dissolve components (1), (11) to (14) uniformly at 75°C. B: Dissolve components (2) to (10) uniformly at 75°C. C: Gradually add B to A and emulsify using a Despa mixer. Ingredients (15) to (18) were added to D:C and mixed, and the mixture was filled into a tube container to obtain a hand cream (oil-in-water type).

[0109] The hand cream (oil-in-water type) of Example 20 exhibited excellent properties in terms of non-dripping at high temperatures, dispensability at low temperatures, non-greasy feel, and moisturizing effect. Furthermore, the content of component (D) relative to the total amount of oil was 50%.

[0110] Example 21: Cream (Oil-in-Water Type) (Formulation) [Mass %] 1. Heparin-like substance 2.0 2. Polyethylene glycol monostearate (40 E.O.) Note 1 5.0 3. Cetostearyl alcohol 3.0 4. Behenyl alcohol 3.0 5. Vaseline Note 7 10 6. Liquid paraffin 5.0 7. Glyceryl tri-2-ethylhexanoate 5.0 8. Purified water remaining amount 9. 1,3-Butylene glycol 10 10. Glycerin 5.0 11. Phenoxyethanol 0.5

[0111] (Manufacturing method) A: Dissolve a portion of components (1) and (8) uniformly at 75°C. B: Dissolve components (2) to (7) uniformly at 75°C. C: Gradually add B to A and emulsify using a Despa mixer. Components (9) to (11) were added to D:C and mixed, and the mixture was filled into a tube container to obtain a cream (oil-in-water type).

[0112] The cream formulation (oil-in-water type) of Example 21 exhibited excellent properties in terms of non-dripping at high temperatures, dispensability at low temperatures, non-stickiness, and moisturizing effect. Furthermore, the content of component (D) relative to the total amount of oil was 50%.

Claims

1. The following components (A) to (D): (A) Heparin-like substances (B) Polyethylene glycol monostearate 1-5% by mass (C) Higher alcohols with 12 to 22 carbon atoms: 1 to 10% by mass (D) One or more substances selected from the group consisting of hydrocarbon oils and ester oils that exhibit a paste-like consistency at 25°C. (E) Liquid oil at 25°C: 5 to 30% by mass The composition contains the above component (D) with respect to the total amount of oil in the composition being 20% ​​by mass or more. The aforementioned component (D) comprises one or more selected from the group consisting of petrolatum, sterol fatty acid esters, and N-acyl amino acid sterol esters. The aforementioned component (E) comprises one or more selected from the group consisting of hydrocarbon oils and ester oils. Oil-in-water emulsion composition.

2. The oil-in-water emulsion composition according to claim 1, wherein component (D) contains a hydrocarbon oil and an ester oil.

3. The oil-in-water emulsion composition according to claim 1 or 2, wherein the total content of component (D) and component (E) [(D) + (E)] is 20 to 40% by mass.

4. The oil-in-water emulsion composition according to claim 1 or 2, wherein the ester oil of component (D) is a sterol fatty acid ester and an N-acyl amino acid sterol ester.

5. The oil-in-water emulsion composition according to claim 1 or 2, wherein the sterol fatty acid ester of component (D) is one or two selected from phytosteryl oleate and phytosteryl macadamia nut oil fatty acid, and the N-acyl amino acid sterol ester of component (D) is one or more selected from N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl), and N-lauroyl-L-glutamic acid di(phytosteryl / 2-octyldodecyl).

6. The oil-in-water emulsion composition according to claim 1 or 2, wherein component (E) contains component (E1) hydrocarbon oil and ester oil.

7. The oil-in-water emulsion composition according to claim 1 or 2, wherein the mass ratio of hydrocarbon oil to ester oil [hydrocarbon oil / ester oil] in component (D) is 1 to 10.

8. A cosmetic or topical skin preparation containing the oil-in-water emulsion composition described in claim 1 or 2.

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