Vesicle-containing cosmetics

Abstract

The present invention provides a vesicle-containing cosmetic preparation which is capable of solubilizing an oil component at a higher concentration in comparison to the cases where micelles are used, and which preferably has excellent transparency.　A vesicle-containing cosmetic preparation according to the present disclosure contains a dispersion medium that contains water and vesicles that are dispersed in the dispersion medium; the vesicles are formed of at least one polyglycerol fatty acid ester that has an OH / C ratio of 0.20 to 0.80; and an oil component is contained in bilayer membranes of the vesicles.

Description

Technical Field

[0001] The present disclosure relates to a vesicle-containing cosmetic.

Background Art

[0002] Among amphiphilic compounds having both hydrophilic and hydrophobic properties, there are compounds, such as phospholipids, that form spherical vesicles composed of bilayers like lamellar layers in an aqueous phase. Such bilayer vesicles are called liposomes or vesicles, and they are used in cosmetics and the like.

[0003] Patent Document 1 discloses a cosmetic composition for hair care, which contains, in a continuous aqueous dispersion phase: (a) vesicles prepared from a lipid phase containing at least one amphiphilic lipid in which at least one ionic or nonionic stabilizer is associated, the vesicles containing an aqueous phase confined therein; and (b) at least one natural or synthetic essential oil in the form of droplets dispersed in the aqueous dispersion phase, wherein the essential oil is present in an amount of 0.2 to 20 wt% relative to the total weight of the composition, and the weight ratio of the lipid phase to the essential oil is 0.3 to 10.

[0004] Patent Document 2 discloses a vesicle composition for blending into an external skin preparation or cosmetic aiming at improving permeability of an active ingredient to skin or hair, wherein the vesicle composition contains (A) polyglycerol fatty acid ester, (B) polyol, and (C) water as essential components, and has an average particle diameter of 30 to 300 nm.

Prior Art Literature

Patent Literature

[0005]

Patent Document 1

Patent Document 2

Summary of the Invention

Problem to be Solved by the Invention

[0006] A known technique for solubilizing oils is the use of micelles prepared with surfactants. However, since micelles can only solubilize a small amount of oil, there has been a demand for a technique that can solubilize oils at a higher concentration than micelles.

[0007] On the other hand, micelles have the advantage of easily producing transparent cosmetics even when oil is solubilized. Since vesicles generally have a larger particle size than micelles, vesicles have not been used until now to obtain transparent cosmetics with solubilized oil.

[0008] Therefore, the subject of this disclosure is to provide a vesicle-containing cosmetic that can solubilize oil at a higher concentration compared to cases using micelles, and preferably has excellent transparency. [Means for solving the problem]

[0009] <Aspect 1> A dispersion medium containing water, and Vesicles dispersed in the aforementioned dispersion medium, A vesicle-containing cosmetic composition, The vesicle is formed of at least one polyglycerol fatty acid ester having an OH / C ratio of 0.20 to 0.80, and contains oil in the bilayer film of the vesicle. Cosmetics containing vesicles. <Aspect 2> The vesicle-containing cosmetic composition according to Embodiment 1, wherein the cosmetic composition exhibits an L value of 50 or more. <Aspect 3> The cosmetic composition according to embodiment 1 or 2, wherein the OH / C ratio of the polyglycerin fatty acid ester is 0.20 to 0.60. <Aspect 4> The cosmetic composition according to any one of embodiments 1 to 3, wherein the mass ratio of the oil to the polyglycerin fatty acid ester is 0.01 or more and 0.30 or less. <Aspect 5> The cosmetic composition according to any one of embodiments 1 to 4, wherein the number of carbon atoms in the fatty acid portion of the polyglycerin fatty acid ester is 12 or more and 17 or less. <Pattern 6> The cosmetic composition according to any one of embodiments 1 to 5, wherein the polyglycerin portion of the polyglycerin fatty acid ester is formed of polyglycerin in dimers or decamers or less. <Aspect 7> A cosmetic composition according to any one of embodiments 1 to 6, further comprising an anionic surfactant. <Aspect 8> The cosmetic composition according to embodiment 7, comprising micelles containing the anionic surfactant. <Aspect 9> A cosmetic composition according to any one of embodiments 1 to 8, further comprising alcohol. [Effects of the Invention]

[0010] According to this disclosure, it is possible to solubilize oil at a higher concentration compared to cases using micelles, and preferably to provide a vesicle-containing cosmetic composition with excellent transparency. [Modes for carrying out the invention]

[0011] The embodiments of this disclosure will be described in detail below. This disclosure is not limited to the embodiments described below, and can be implemented in various ways within the scope of the essence of the invention.

[0012] The vesicle-containing cosmetic composition of this disclosure comprises a dispersion medium containing water, and vesicles dispersed in the dispersion medium, wherein the vesicles are formed by at least one polyglycerol fatty acid ester having an OH / C ratio of 0.20 to 0.80, and contain oil in the bilayer film of the vesicles.

[0013] Although not limited by principle, we believe that the mechanism by which the vesicle-containing cosmetic composition of this disclosure can solubilize oil at high concentrations is as follows.

[0014] It is known that silicone-based surfactants, block-type alkylene oxide derivatives, phospholipids, and the like can be used as amphipathic substances capable of forming vesicles. However, not all vesicles formed from these various amphipathic substances are capable of solubilizing oil components at high concentrations. Furthermore, not all vesicles formed from these various amphipathic substances are excellent in transparency.

[0015] The present inventor found that when a specific polyglycerol fatty acid ester whose OH / C ratio, a parameter relating to the balance between hydrophilicity and lipophilicity, falls within the range of 0.20 to 0.80 is selected from among various amphipathic substances capable of forming vesicles, vesicles capable of solubilizing oil components at high concentrations can be obtained. Furthermore, the present inventor also found that when such a specific polyglycerol fatty acid ester is used, a vesicle-containing cosmetic excellent in transparency can be obtained.

[0016] In general, when an oil component is solubilized at a high concentration in an aggregate having solubilizing ability such as a micelle, the balance between hydrophilicity and lipophilicity is disrupted. Therefore, it is common that the oil component precipitates to cause clouding, or the particle size of solubilized particles increases to lower transparency. It is considered that this phenomenon can similarly occur also in vesicles.

[0017] It is considered that since vesicles formed from the above-mentioned specific polyglycerol fatty acid ester have excellent packing properties of the constituent bilayer membrane, even when an oil component is incorporated into the bilayer membrane at a high concentration, the collapse of vesicles and the increase in vesicle diameter can be suitably reduced or suppressed, and thus the oil component can be solubilized at a high concentration. In addition, it is considered that since vesicles formed from the above-mentioned specific polyglycerol fatty acid ester have a relatively smaller particle diameter compared to vesicles formed from other amphipathic substances, a vesicle-containing cosmetic excellent in transparency can be obtained.

[0018] Although the cosmetic composition described in Patent Document 1 contains an essential oil together with vesicles, in said composition, the essential oil is added to the dispersion after forming the vesicle-containing dispersion, and therefore the essential oil is not solubilized in the bilayer membrane of the vesicles.

[0019] <Vesicle-Containing Cosmetic> <Dispersion Medium> The dispersion medium (aqueous phase) in the vesicle-containing cosmetic of the present disclosure (sometimes simply referred to as "cosmetic") contains water.

[0020] (Water) There are no particular restrictions on the blending amount of water. For example, it may be 20% by mass or more, 30% by mass or more, 40% by mass or more, 50% by mass or more, 60% by mass or more, 70% by mass or more, or 80% by mass or more relative to the total amount of the cosmetic, and may also be 95% by mass or less, 90% by mass or less, 85% by mass or less, 80% by mass or less, 75% by mass or less, 70% by mass or less, 65% by mass or less, 60% by mass or less, 55% by mass or less, or 50% by mass or less.

[0021] There are no particular restrictions on water that can be used in the vesicle-containing cosmetic of the present disclosure, and for example, water used in cosmetics and quasi-drugs can be used. For example, ion-exchanged water, distilled water, ultrapure water, and tap water can be used.

[0022] <Vesicles> The vesicle-containing cosmetic of the present disclosure contains vesicles as a dispersed phase, and an oil component is contained in the bilayer membrane of said vesicles.

[0023] The presence of vesicles in cosmetics can be confirmed, for example, using a freeze-replica method with a freeze-replica transmission electron microscope (TEM, H-7650: Hitachi, Ltd.), or using a small-angle X-ray scattering analyzer (SAXSess, Anton Paar) and a zetasizer nano (Malvern Panalytical). Vesicles typically disperse in the aqueous phase as dispersions of vesicles in which lamellar liquid crystals are closed in a concentric spherical shape. Using a small-angle X-ray scattering analyzer, if lamellar liquid crystals are present in the cosmetic, the size of the layered structure in these lamellar liquid crystals can be measured. In other words, using a small-angle X-ray scattering analyzer, the presence of vesicles in cosmetics can be confirmed from the presence or absence of lamellar liquid crystals and their size.

[0024] In some embodiments, the average particle size of vesicles in a cosmetic can be 200 nm or less, 150 nm or less, 100 nm or less, 80 nm or less, or 60 nm or less, and can also be 10 nm or more, 20 nm or more, 30 nm or more, 40 nm or more, or 50 nm or more. Vesicles having such average particle sizes can further improve the transparency of the cosmetic. Here, the average particle size of vesicles can be measured using the freeze-replica method from photographs taken with a freeze-replica transmission electron microscope (TEM, H-7650: manufactured by Hitachi, Ltd.). Such an average particle size is the average value of 10 or more arbitrarily selected vesicles.

[0025] (Polyglycerin fatty acid ester) The vesicles of this disclosure are formed by at least one polyglycerol fatty acid ester having an OH / C ratio of 0.20 to 0.80.

[0026] Polyglycerin fatty acid esters are a sustainable material, and as an added benefit, they can provide a moisturizing feel when applied to the skin and can also improve occlusion.

[0027] The amount of polyglycerin fatty acid ester in the vesicle-containing cosmetic composition of this disclosure can be 0.1% by mass or more, 0.3% by mass or more, or 0.5% by mass or more, relative to the total amount of the cosmetic composition, from the viewpoint of vesicle formation, oil solubilization ability in vesicles, and transparency of the vesicle-containing cosmetic composition. It can also be 10% by mass or less, 5.0% by mass or less, or 3.0% by mass or less.

[0028] Polyglycerol fatty acid esters can be prepared by esterifying a fatty acid with polyglycerol, as shown in the following reaction equation: [ka]

[0029] Here, in polyglycerol fatty acid esters, the part derived from fatty acids can be called the fatty acid portion, and the part derived from polyglycerol can be called the polyglycerol portion. The fatty acid portion corresponds to the lipophilic portion, and the polyglycerol portion corresponds to the hydrophilic portion.

[0030] The OH / C ratio of the polyglycerin fatty acid ester is preferably 0.20 or higher, 0.25 or higher, 0.30 or higher, 0.35 or higher, 0.40 or higher, 0.45 or higher, or 0.50 or higher, and more preferably 0.80 or lower, 0.75 or lower, 0.70 or lower, 0.65 or lower, or 0.60 or lower. Polyglycerin fatty acid esters having such an OH / C ratio can improve the solubilizing ability of oil in vesicles and provide vesicle-containing cosmetics with excellent transparency.

[0031] Here, in this disclosure, "OH / C ratio" means the ratio of the number of hydroxyl groups in the polyglycerin portion to the number of carbon atoms in the fatty acid portion, and is a parameter relating to the balance between hydrophilicity and lipophilicity. For example, in the case of polyglyceryl-6 myristate, the number of carbon atoms in the fatty acid portion is 14, and the polyglycerin portion is a hexamer with 7 hydroxyl groups (=6+1), so the OH / C ratio is 0.50 (=7 / 14).

[0032] As for polyglycerin fatty acid esters, from the viewpoint of oil solubilization ability in vesicles and transparency of vesicle-containing cosmetics, it is preferable that the number of carbon atoms in the fatty acid portion is 12 or more, 13 or more, or 14 or more, and also preferable that it is 17 or less, 16 or less, or 15 or less.

[0033] The fatty acids that can be used when preparing polyglycerol fatty acid esters may be saturated or unsaturated fatty acids, and may be straight-chain or branched-chain fatty acids. Examples of such fatty acids include lauric acid, myristic acid, and palmitic acid. Among these, myristic acid and lauric acid are preferred.

[0034] The polyglycerin portion of the polyglycerin fatty acid ester is preferably in the form of 2 or more, 3 or more, or 4 or more, from the viewpoint of oil solubilization ability in vesicles and transparency of vesicle-containing cosmetics, and is also preferably 10 or less, 9 or less, 8 or less, 7 or less, or 6 or less. Here, the value of n in the polyglycerin fatty acid ester in the above reaction formula is, for example, the same as the value of 2 in the dimer.

[0035] Examples of polyglycerin fatty acid esters with an OH / C ratio of 0.20 to 0.80 include, for example, polyglyceryl-6 myristate, polyglyceryl-2 laurate, polyglyceryl-4 laurate, polyglyceryl-5 laurate, polyglyceryl-6 laurate, and polyglyceryl-10 palmitate.

[0036] (Oil content) Since the vesicles of this disclosure are formed using the specific polyglycerol fatty acid esters described above, they can solubilize oil at a higher concentration in the vesicle's bilayer film compared to, for example, micelles formed using such polyglycerol fatty acid esters.

[0037] The solubilizing ability of vesicles can be evaluated by the mass ratio of oil to polyglycerol fatty acid ester. Such mass ratios can be, for example, 0.01 or higher, 0.03 or higher, 0.05 or higher, 0.07 or higher, or 0.10 or higher, and can also be 0.30 or lower, 0.27 or lower, 0.25 or lower, 0.23 or lower, or 0.20 or lower.

[0038] There are no particular restrictions on the type of oil that can be solubilized in the vesicle bilayer. For example, volatile oils and non-volatile oils can be used as oils. Oils can be used alone or in combination of two or more types. Here, "volatile" refers to oils that exhibit more than 5% volatile content when left at atmospheric pressure and 105°C for 3 hours. Volatile content can also be set to 10% or more, 20% or more, 40% or more, 50% or more, 60% or more, 80% or more, or 100%. Alternatively, the boiling point at 1 atmosphere (101.325 kPa) can be used as a guideline for volatility. This boiling point can be 250°C or less, 240°C or less, or 230°C or less, and can also be 80°C or more, 100°C or more, 120°C or more, 150°C or more, or 160°C or more. Furthermore, in this disclosure, "non-volatile" means that the volatile content is 5% or less when left standing at 105°C for 3 hours.

[0039] There are no particular restrictions on the volatile oils used; for example, volatile silicone oils and volatile hydrocarbon oils can be used. Volatile oils can be used alone or in combination of two or more types.

[0040] Examples of volatile silicone oils include volatile acyclic silicone oils and volatile cyclic silicone oils.

[0041] As volatile acyclic silicone oils, for example, volatile linear silicone oils and volatile branched silicone oils can be used.

[0042] Examples of volatile linear silicone oils include low molecular weight linear dimethylpolysiloxanes such as dimethylpolysiloxane with a viscosity of 0.65 cs (sometimes referred to as "dimethicone"), dimethylpolysiloxane with a viscosity of 1 cs, dimethylpolysiloxane with a viscosity of 1.5 cs, and dimethylpolysiloxane with a viscosity of 2 cs. Among these, dimethylpolysiloxane with a viscosity of 2 cs is preferred from the viewpoint of solubilizing ability for vesicles and transparency of vesicle-containing cosmetics. Here, these viscosities refer to the kinematic viscosity at a 25°C atmosphere.

[0043] Examples of volatile branched silicone oils include low molecular weight branched siloxanes such as methyl trimethicone, tris(trimethylsilyl)methylsilane, and tetrakis(trimethylsilyl)silane.

[0044] Examples of volatile cyclic silicone oils include octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane.

[0045] Examples of volatile hydrocarbon oils include heptane, isododecane, isohexadecane, and isodecane. Among these, isohexadecane is preferred from the viewpoint of its solubilizing ability for vesicles and the transparency of vesicle-containing cosmetics.

[0046] In addition to the volatile oils mentioned above, other oils commonly used in cosmetics include liquid oils, solid oils, waxes, hydrocarbon oils other than those mentioned above, silicone oils other than those mentioned above, and polar oils. Some UV absorbers act as oils, particularly polar oils. Such UV absorbers can also be considered as oils.

[0047] Examples of liquid oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, peach kernel oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, elm oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnamon oil, Japanese tuni oil, jojoba oil, wheat germ oil, and triglycerin.

[0048] Examples of solid fats and oils include cocoa butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, sheep fat, hydrogenated beef tallow, palm kernel oil, pork fat, beef bone fat, Japanese wax kernel oil, hydrogenated oil, beef foot tallow, Japanese wax, and hydrogenated castor oil.

[0049] Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, privet wax, whale wax, montan wax, rice bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, isopropyl lanolin fatty acid, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether.

[0050] Examples of hydrocarbon oils include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and olefin oligomers.

[0051] Examples of silicone oils include chain-like silicones such as dimethylpolysiloxane (dimethicone), methylphenylpolysiloxane (diphenylsiloxyphenyl trimethicone), and methylhydrogenpolysiloxane, which have a viscosity of 6 cs or higher.

[0052] As polar oils, for example, polar oils with an IOB of 0.10 or higher can be used. Examples of such polar oils include isopropyl myristate (IOB value = 0.18), octyl palmitate (IOB value = 0.13), isopropyl palmitate (IOB value = 0.16), butyl stearate (IOB value = 0.14), hexyl laurate (IOB value = 0.17), myristyl myristate (IOB value = 0.11), decyl oleate (IOB value = 0.11), isononyl isononanoate (IOB value = 0.20), and isotridecyl isononanoate (I (IOB value = 0.15), Cetyl ethylhexanoate (IOB value = 0.13), Pentaerythrityl tetraethylhexanoate (IOB value = 0.35), Diethylhexyl succinate (IOB value = 0.32), Dioctyl succinate (IOB value = 0.36), Glycol distearate (IOB value = 0.16), Glyceryl diisostearate (IOB value = 0.29), Neopentyl glycol dicaprate (IOB value = 0.25), Diisostearyl malate (IOB value = 0.28) ), trimethylolpropane triisostearate (IOB value = 0.16), glyceryl tri-2-ethylhexanoate (triethylhexanoin) (IOB value = 0.35), trimethylolpropane trioctanoate (IOB value = 0.33), trimethylolpropane triisostearate (IOB value = 0.16), diisobutyl adipate (IOB value = 0.46), N-lauroyl-L-glutamic acid-2-octyldodecyl ester (IOB value = 0.29), adipic acid Examples include 2-hexyldecyl (IOB value = 0.16), diisopropyl sebacate (IOB value = 0.40), ethylhexyl methoxycinnamate (IOB value = 0.28), 2-ethylhexyl palmitate (IOB value = 0.13), 2-ethylhexyl ethylhexanoate (IOB value = 0.2), triisostearin (IOB value = 0.16), PPG-3 dipivalate (IOB value = 0.52), and tri(caprylic / capric acid) glyceryl (IOB value = 0.33). Among these, pentaerythrityl tetraethylhexanoate (IOB value = 0.35) is preferred from the viewpoint of solubilizing ability for vesicles and transparency of vesicle-containing cosmetics.

[0053] Examples of UV absorbers that can be considered as oils include those with an IOB of 0.10 or higher, specifically organic UV absorbers such as ethylhexyl methoxycinnamate, octocrylene, polysilicone-15, t-butyl methoxydibenzoylmethane, ethylhexyl triazone, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylamino hydroxybenzoyl hexyl benzoate, oxybenzone-3, methylenebisbenzotriazolyltetramethylbutylphenol, homosalate, and ethylhexyl salicylate. UV absorbers can be used alone or in combination of two or more.

[0054] The IOB values ​​of polar oils and UV absorbers can be, for example, 0.11 or higher, 0.12 or higher, or 0.13 or higher, and can also be 0.50 or lower, 0.45 or lower, or 0.40 or lower. Here, the IOB value is an abbreviation for Inorganic / Organic Balance, and is a value that represents the ratio of the inorganic value to the organic value, and serves as an indicator of the degree of polarity of organic compounds. Specifically, the IOB value is expressed as IOB value = inorganic value / organic value. For each of the "inorganic value" and "organic value," for example, one carbon atom in a molecule has an "organic value" of 20, and one hydroxyl group has an "inorganic value" of 100. These values ​​are assigned according to the type of atom or functional group, and the IOB value of an organic compound can be calculated by summing the "inorganic value" and "organic value" of all atoms and functional groups in the organic compound (see, for example, Yoshio Koda, "Organic Concept Diagram - Fundamentals and Applications," pp. 11-17, Sankyo Publishing, 1984).

[0055] In some embodiments, among the oils mentioned above, silicone oil is preferred from the viewpoint of transparency of the vesicle-containing cosmetic composition.

[0056] <Optional ingredients> The vesicle-containing cosmetic composition of this disclosure may contain various components as appropriate, provided that they do not adversely affect the effects of this disclosure. Examples of various components include additives that can be normally incorporated into cosmetics, such as surfactants other than polyglycerin fatty acid esters (e.g., anionic surfactants), humectants, thickeners, water-soluble polymers, oil-soluble polymers, film-forming agents, higher fatty acids, metal ion chelating agents, alcohols (e.g., lower alcohols such as ethanol, higher alcohols, polyhydric alcohols such as glycols), various extracts, sugars, amino acids, organic amines, polymer emulsions, chelating agents, other UV absorbers other than the UV absorbers mentioned above, pH adjusters, skin nutrients, vitamins, water-soluble agents applicable to pharmaceuticals, quasi-drugs, cosmetics, etc., buffers, anti-fading agents, preservatives, propellants, fillers, pigments, dyes, colorants, fragrances, etc. Optional components can be incorporated into the oil phase and / or aqueous phase and can be used alone or in combination of two or more.

[0057] Among optional components, the use of anionic surfactants can function as a dispersant for vesicles in cosmetics, thereby further improving the transparency and long-term stability of vesicle-containing cosmetics. In some embodiments, at least a portion of the anionic surfactant is included in the cosmetic in the form of micelles containing such surfactant in the aqueous phase.

[0058] Examples of such anionic surfactants include N-acyl amino acid salts and N-acyl methyl taurate salts. Specifically, examples include N-acyl glutamates such as potassium cocoyl glutamate, N-acyl-N-methyl-β-alanine salts, N-acyl sarcosinate salts, sodium N-cocoyl taurate, sodium N-cocoyl-N-methyl taurate, sodium N-lauroyl-N-methyl taurate, sodium N-coconut oil fatty acid-N-methyl taurate, sodium N-coconut oil fatty acid-N-methyl taurate, N-coconut oil fatty acid-N-methyl taurate triethanolamine, N-palm oil fatty acid-N-ethyl taurate triethanolamine, magnesium N-cocoyl taurate, magnesium N-cocoyl-N-methyl taurate, magnesium N-lauroyl-N-taurate, magnesium N-lauroyl-N-methyl taurate, and magnesium N-coconut oil fatty acid-N-methyl taurate. Among these, sodium N-cocoyl-N-methyltaurate is preferred. Anionic surfactants can be used alone or in combination of two or more.

[0059] From the viewpoint of transparency and long-term stability of vesicle-containing cosmetics, the amount of anionic surfactant blended is preferably 0.01% by mass or more, 0.03% by mass or more, 0.05% by mass or more, or 0.07% by mass or more, relative to the total amount of the cosmetic, and also preferably 1.0% by mass or less, 0.7% by mass or less, 0.5% by mass or less, or 0.3% by mass or less.

[0060] Furthermore, the inclusion of alcohol as an optional ingredient can further improve the oil-solubilating ability in vesicles or the transparency of vesicle-containing cosmetics. Examples of such alcohols include lower alcohols, polyhydric alcohols, and higher alcohols. Among these, lower alcohols and / or polyhydric alcohols are preferred. Alcohols can be used alone or in combination of two or more types.

[0061] As lower alcohols, for example, monohydric alcohols having an alkyl group with 1 to 5 carbon atoms are preferred, and monohydric alcohols having an alkyl group with 1 to 3 carbon atoms are more preferred. Specifically, examples include ethanol, propanol, isopropanol, isobutyl alcohol, and t-butyl alcohol, with ethanol being the most preferred. Lower alcohols can be used alone or in combination of two or more.

[0062] Examples of polyhydric alcohols include ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, and polybutylene glycol. Among these, dipropylene glycol is preferred. Polyhydric alcohols can be used alone or in combination of two or more.

[0063] Examples of higher alcohols include those with a carbon chain length of 16 or more. Specific examples include linear or branched higher alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearylglycelene ether (batyl alcohol), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, and octyldodecanol.

[0064] From the viewpoint of the oil-solubilizing ability in vesicles and the transparency of vesicle-containing cosmetics, the amount of alcohol blended is preferably 1.0% by mass or more, 3.0% by mass or more, 5.0% by mass or more, or 7.0% by mass or more, relative to the total amount of the cosmetic, and also preferably 20.0% by mass or less, 17.0% by mass or less, or 15.0% by mass or less.

[0065] <L value of cosmetics> The vesicle-containing cosmetic composition of this disclosure can exhibit excellent transparency despite the vesicles solubilizing oil. The transparency of the cosmetic composition can be evaluated by the L value calculated from a colorimeter such as COLOR-EYE 7000A (manufactured by Gretag Macbeth). An L value closer to 100 indicates higher transparency. The cosmetic composition of this disclosure can exhibit L values ​​of 50 or higher, 55 or higher, 60 or higher, 65 or higher, 70 or higher, 75 or higher, 80 or higher, 85 or higher, or 90 or higher. There is no particular upper limit to the L value; for example, it can be 100 or less.

[0066] Method for preparing cosmetics containing vesicles The vesicle-containing cosmetic composition of this disclosure can be prepared in the following manner, although this method is not limited to the following. The various materials described above can be used in the preparation of the cosmetic composition.

[0067] For example, a mixture can be formed by mixing the aforementioned polyglycerol fatty acid ester, which can form a vesicle bilayer, with an oil and optionally an oil-soluble agent. Then, this mixture can be added to water, which optionally contains a water-soluble agent, and stirred and mixed to obtain the vesicle-containing cosmetic composition of this disclosure. By preparing the cosmetic composition in this order, the oil can be solubilized within the vesicle bilayer.

[0068] Formulations of cosmetics containing vesicles There are no particular restrictions on the dosage form of the vesicle-containing cosmetic composition of this disclosure, and examples include liquid, emulsion, cream, gel, spray, and mousse. Herein, "spray" in this disclosure can include mist-type sprays, aerosol-type sprays, and the like.

[0069] Uses of cosmetics containing vesicles The vesicle-containing cosmetic composition of this disclosure can be used, for example, as a cosmetic composition that is spread and applied to the skin or hair.

[0070] The cosmetic products described herein are not limited in any particular form, but examples include facial cosmetics such as lotions, serums, emulsions, and masks; makeup cosmetics such as foundations, lipsticks, and eyeshadows; sunscreens; body cosmetics; hair cosmetics such as hair liquids, hair tonics, hair conditioners, shampoos, rinses, and hair growth products; and ointments. [Examples]

[0071] The following examples will provide a more detailed explanation of the vesicle-containing cosmetics of this disclosure, but the cosmetics of this disclosure are not limited to these examples. Unless otherwise specified, the amounts are expressed in mass percent.

[0072] Examples 1-13 and Comparative Examples 1-2 The vesicle-containing cosmetic compositions obtained using the formulations shown in Tables 1 and 2 and the manufacturing methods described below were evaluated as follows, and the results are shown in Tables 1 and 2. <Evaluation Method> (Vesicle evaluation) The prepared cosmetic samples were observed using a freeze-replica transmission electron microscope (TEM, H-7650: Hitachi, Ltd.) using the freeze-replica method to check for the presence or absence of vesicles. In the table, "Present" indicates when vesicles were found, and "Absent" indicates when they were not found.

[0073] (Evaluation of L value) The L value, an indicator of transparency, was evaluated using a colorimeter, COLOR-EYE 7000A (manufactured by Gretag Macbeth). For cosmetics that are cloudy and difficult to measure accurately, "20 or less" is indicated in the table.

[0074] (Evaluation of appearance) The prepared cosmetic was added to a 50 mL clear glass bottle (outer diameter 2.5 cm), and its appearance was visually observed under a 25°C atmosphere and evaluated according to the following criteria. Here, A and B ratings are considered pass, and C rating is considered fail: A: The cosmetic product was not cloudy, and it was possible to see the other side of the cosmetic product through the glass bottle. B: The cosmetic was slightly cloudy, but it was possible to see the other side of the cosmetic through the glass bottle. C: The cosmetic was cloudy, and it was not possible to see the other side of the cosmetic through the glass bottle.

[0075] <Method of manufacturing cosmetics> Vesicle-containing cosmetics were manufactured using the formulations shown in Tables 1 and 2 by the following method. Here, the numbers shown below correspond to the numbers on the left indicating the ingredient names in the formulations in Tables 1 and 2.

[0076] (Example 1) Materials No. 4 and No. 10 were uniformly mixed to obtain the oil phase component.

[0077] Materials No. 1, No. 2, and No. 9 were uniformly mixed to obtain the aqueous phase component.

[0078] The oil phase component was added to the aqueous phase component and uniformly dispersed using a dispenser to obtain the vesicle-containing cosmetic composition of Example 1.

[0079] (Examples 2-7 and Comparative Examples 1-2) Except for the changes in the formulation shown in Table 1, the vesicle-containing cosmetic compositions of Examples 2-7 and Comparative Examples 1-2 were obtained in the same manner as in Example 1.

[0080] (Example 8) Materials No. 2, No. 4, and No. 5 were uniformly mixed to obtain the oil phase component.

[0081] No. 1 was designated as the aqueous phase component.

[0082] The oil phase component was added to the aqueous phase component and uniformly dispersed using a magnetic stirrer to obtain the vesicle-containing cosmetic composition of Example 8.

[0083] (Examples 9-13) Except for the changes in the formulation shown in Table 2, the vesicle-containing cosmetic compositions of Examples 9 to 13 were obtained in the same manner as in Example 8.

[0084] [Table 1]

[0085] [Table 2]

[0086] <result> Table 1 shows that vesicles were formed in the cosmetic compositions of Comparative Examples 1 and 2, and despite using the same amount of oil as the cosmetic composition of Example 1, the cosmetic compositions of Comparative Examples 1 and 2 were both cloudy. This is thought to be because the vesicles in Comparative Examples 1 and 2 were unable to completely solubilize the blended oil, and some of it precipitated in the aqueous phase.

[0087] On the other hand, when using polyglycerin fatty acid esters with an OH / C ratio of 0.20 to 0.80, it was confirmed that oil could be solubilized at a higher concentration compared to the cosmetics of Comparative Examples 1 and 2. Furthermore, it was confirmed that when such polyglycerin fatty acid esters were used, vesicle-containing cosmetics with excellent transparency could be obtained.

[0088] Furthermore, the results from Examples 6 and 7 in Table 1 confirm that the vesicle-containing cosmetic composition of this disclosure can be solubilized at high concentrations in any type of oil and can exhibit good transparency. In particular, it was found that even better transparency can be obtained when silicone oil is used as the oil.

[0089] The results in Table 2 show that when vesicle-containing cosmetics also contain alcohol, it is possible to solubilize oil at a high concentration and further improve transparency.

Claims

1. A dispersion medium containing water, and Vesicles dispersed in the aforementioned dispersion medium, A vesicle-containing cosmetic composition, The vesicle is formed by at least one type of polyglycerol linear fatty acid ester having an OH / C ratio of 0.35 to 0.80, and contains oil in the bilayer film of the vesicle. The mass ratio of the oil to the polyglycerol linear fatty acid ester is 0.01 or more and 0.30 or less. Cosmetics containing vesicles.

2. The vesicle-containing cosmetic composition according to claim 1, wherein the cosmetic composition exhibits an L value of 50 or more.

3. The cosmetic composition according to claim 1 or 2, wherein the OH / C ratio of the polyglycerin linear fatty acid ester is 0.35 to 0.

60.

4. The cosmetic composition according to any one of claims 1 to 3, wherein the number of carbon atoms in the fatty acid portion of the polyglycerin linear fatty acid ester is 12 or more and 17 or less.

5. The cosmetic composition according to any one of claims 1 to 4, wherein the polyglycerin portion of the polyglycerin linear fatty acid ester is formed of polyglycerin in dimers or decapers or less.

6. A cosmetic composition according to any one of claims 1 to 5, further comprising an anionic surfactant.

7. The cosmetic composition according to claim 6, comprising micelles containing the anionic surfactant.

8. A cosmetic composition according to any one of claims 1 to 7, further comprising alcohol.

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