Epidermal keratinocyte proliferation promoter, skin turnover promoter, skin metabolism promoter, topical skin composition, method for promoting epidermal keratinocyte proliferation, method for promoting skin turnover, and method for promoting skin metabolism

Abstract

To provide preparations that can prevent deterioration of skin metabolism function caused by various factors such as aging and ultraviolet disorders, a decrease in the speed of epidermal turnover, and deterioration of the skin environment caused thereby, and thereby can prevent skin aging phenomena such as fine wrinkles and dullness of the skin, and aging odor, scalp odor and the like.SOLUTION: An epidermal keratinocyte growth stimulator, a skin turnover promoter, a skin metabolism promoter, or a topical skin composition containing them, characterized by containing as an active ingredient a lactone compound represented by formula (I), wherein they are used for preventing and / or improving at least one symptom selected from the group consisting of fine wrinkles of skin, darkening, lost texture, degraded firmness, pigmentation, tone-down of skin, stiff skin, rough skin, aging odor, and scalp odor. (In the formula, R is an alkyl group having 2 to 9 carbon atoms).SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an epidermal keratinocyte proliferation promoter, a skin turnover promoter, a skin metabolism promoter, an external composition for skin, a method for promoting epidermal keratinocyte proliferation, a method for promoting skin turnover, and a method for promoting skin metabolism. Background Art

[0002] The skin is a layered tissue that covers the human body and forms a boundary with the external environment. The skin has a four-layer structure starting from the basal layer, the lowermost layer, followed by the spinous layer, the granular layer, and the stratum corneum. Most of the cells present in each layer are keratinocytes differentiated from the basal layer. Keratinocytes that divide and proliferate in the basal layer differentiate while passing through the spinous layer and the granular layer to become corneocytes, which constitute the stratum corneum formed of keratin protein fibers with strong cross-linking bonds, and eventually fall off from the stratum corneum as scales. In normal skin, the outermost stratum corneum acts as a barrier, preventing excessive loss of skin moisture to the outside and blocking the invasion of foreign substances such as bacteria and harmful substances from the external environment (see Non-Patent Documents 1 and 2). To maintain this barrier function, the skin repeats the cycle (keratinization) from production of keratinocytes in the basal layer to shedding as scales, which normally takes 4 weeks (this process is called skin turnover), and performs epidermal metabolism.

[0003] However, when the proliferation and division ability of epidermal keratinocytes decreases due to various factors such as aging and damage caused by excessive ultraviolet radiation, the metabolic function of epidermal keratinocytes declines, and the rate of epidermal turnover slows down (see Non-Patent Documents 1 and 2). This leads to epidermal thinning and thickening of the stratum corneum, which causes fine wrinkles and skin coarseness, and also impairs melanin excretion, resulting in pigmentation and skin dullness (see Non-Patent Documents 2 and 3).

[0004] Therefore, it is thought that if the proliferation of epidermal keratinocytes can be promoted, skin turnover will be accelerated and the skin's metabolic function will be restored, thereby improving skin symptoms such as fine wrinkles, dullness, and pigmentation as described above. To date, there have been reports of substances that promote the proliferation of epidermal keratinocytes, for example, that some herbal medicines have this effect (see Non-Patent Document 4). In addition, an epidermal keratinocyte proliferation promoter is known that contains an extract of the germ in the seeds of the lotus (Nelumbo nucifera Gaertn.) of the Nymphaeaceae family as the active ingredient (see Patent Document 1). However, the active ingredients of these substances that promote the proliferation of epidermal keratinocytes have not been identified. Substances that are known to have epidermal keratinocyte proliferation activity and whose active ingredients have been identified include tranexamic acid or its derivatives (see Patent Document 2) and arbutin (see Patent Document 3).

[0005] On the other hand, lactones have peach-like and coconut-like scents and are widely used as fragrance ingredients in perfumes and cosmetics, and as flavoring ingredients in food. In addition to their fragrance properties, lactones are known to have odor-related functions, such as suppressing damp odors, scalp odor, and other unpleasant odors (see Patent Documents 4-6), and improving body odor (see Patent Document 7). Regarding other pharmacological effects of lactones, γ-decanolactone has been shown to have anticonvulsant properties in mouse experimental models (see Non-Patent Document 5), but no other effects are known. [Prior art documents] [Patent Documents]

[0006] [Patent Document 1] Japanese Patent Publication No. 2002-68993 [Patent Document 2] Japanese Patent Publication No. 2015-34155 [Patent Document 3] Japanese Patent Publication No. 2011-173831 [Patent Document 4] Japanese Patent Publication No. 2015-221956 [Patent Document 5] Japanese Patent Publication No. 2015-151531 [Patent Document 6] Japanese Patent Publication No. 2015-193643 [Patent Document 7] Japanese Patent Publication No. 2015-131825 [Non-patent literature]

[0007] [Non-Patent Document 1] Cosmetic Technology Journal, Vol. 23, No. 1, 1989 [Non-Patent Document 2] Production Research, 59, 124-127, 2007 [Non-Patent Document 3] J Gerontol., 38(2), 137-42, 1983 [Non-Patent Document 4] Journal of Japanese and Chinese Medicine, Vol. 15, pp. 426-427, 1998. [Non-Patent Document 5] J Ethnopharmacology, 58, No.3, 175-81, 1997 [Overview of the Initiative] [Problems that the invention aims to solve]

[0008] This invention has been made in view of the above circumstances, and the object of this invention is to provide a formulation that can prevent / improve the decline in the metabolic function of the skin, the decrease in the rate of epidermal turnover, and the deterioration of the skin environment caused by these factors, which occur due to various factors such as aging and damage from ultraviolet rays, thereby preventing / improving so-called skin aging phenomena such as fine wrinkles, dullness, loss of texture, loss of firmness, pigmentation, skin tone down, rough skin, and rough skin, as well as age-related body odor and head odor (including scalp odor), which are thought to be caused in part by an imbalance of resident bacteria due to the deterioration of the skin environment. [Means for solving the problem]

[0009] The present inventors conducted intensive studies to solve the above problem, and as a result, found that lactone, which has been conventionally widely used as a fragrance, has a function of promoting the proliferation of epidermal keratinocytes, and thus completed the present invention. That is, the gist of the present invention is as follows.

[0010] [1] An epidermal keratinocyte proliferation promoter characterized by comprising a lactone compound represented by the following formula (I) as an active ingredient.

Chemical Formula

Chemical Formula

Chemical Formula

Chem.

Chem.

Chem.

[10] The promotion method according to any one of [7] to [9], which is used for preventing and / or improving at least one condition selected from the group consisting of fine wrinkles, dullness, loss of skin texture, reduced skin firmness, pigmentation, uneven skin tone, rough skin, skin roughness, aged odor and scalp odor.

Effect of the Invention

[0011] According to the present invention, it is possible to provide an epidermal keratinocyte proliferation promoter, a skin turnover promoter, and a skin metabolism promoter that can prevent / improve the decline in skin metabolic function, the decrease in the rate of epidermal turnover, and the deterioration of the skin environment caused by these factors, which occur due to various factors such as aging and damage from ultraviolet rays. In doing so, it is possible to prevent skin aging phenomena such as fine wrinkles, dullness, and pigmentation, as well as age-related odor and head odor (including scalp odor), which are thought to be caused in part by an imbalance of resident bacteria due to the deterioration of the skin environment. These promoters of the present invention have the effect of promoting epidermal keratinocyte proliferation, promoting skin turnover, restoring the metabolic function of the skin, or preventing and / or improving at least one symptom selected from the group consisting of fine wrinkles, dullness, loss of texture, loss of firmness, pigmentation, skin tone down, rough skin, skin irritation, age-related body odor, and head odor (including scalp odor). Therefore, they are suitably used in topical skin compositions such as cosmetics and quasi-drugs that are expected to have such effects. [Brief explanation of the drawing]

[0012] [Figure 1] This figure shows the proliferation-promoting effect of lactone on human epidermal keratinocytes. [Modes for carrying out the invention]

[0013] The present invention will be described in detail below. Unless otherwise specified, terms used herein shall be interpreted in the sense commonly used in the art.

[0014] [Epidermal keratinocyte proliferation promoter] The epidermal keratinocyte proliferation promoter of the present invention is characterized by containing a lactone compound represented by the following formula (I) as an active ingredient. By containing the above lactone compound, the epidermal keratinocyte proliferation promoter of the present invention has the effect of promoting the proliferation of epidermal keratinocytes in the skin, thereby promoting skin turnover and restoring the metabolic function of the skin. It is believed that when skin turnover slows down due to aging or other causes, melanin excretion becomes poor, making it easier for pigmentation and dullness to occur. Furthermore, it is believed that when skin metabolism declines, the skin environment deteriorates, the balance of resident bacteria on the skin (including the scalp) is disrupted, and bacteria that cause odor increase, leading to the occurrence of age-related body odor, scalp odor, etc. Therefore, when skin turnover is promoted by the epidermal keratinocyte proliferation promoter of the present invention, it is possible to suppress pigmentation and dullness and improve the function of melanin excretion, and it is expected that skin tone-up effects, improved skin transparency, and improved skin luster can be expected. Furthermore, it can prevent / improve skin problems such as fine wrinkles, loss of skin texture, loss of firmness, rough skin, and skin irritation, as well as age-related body odor and scalp odor. In other words, the epidermal keratinocyte proliferation promoter of the present invention is suitably used to prevent and / or improve at least one symptom selected from the group consisting of fine wrinkles, dullness, loss of skin texture, loss of firmness, pigmentation, skin tone down, rough skin, skin irritation, age-related body odor, and scalp odor. In this specification, scalp odor is a concept that also includes scalp odor. [ka]

[0015] In the formula, R is an alkyl group having 2 to 9 carbon atoms. The number of carbon atoms in R is preferably 3 to 9, more preferably 4 to 9, even more preferably 5 to 8, and particularly preferably 6 or 7. The hydrogen atoms contained in the alkyl group may be substituted.

[0016] Specific examples of lactone compounds represented by the above formula (I) include, for example, γ-hexalactone, γ-heptalactone, γ-octalactone, γ-nonalactone, γ-decalactone, γ-undecalactone, γ-dodecalactone, and γ-tridecalactone. Of these, γ-nonalactone, γ-decalactone, γ-undecalactone, and γ-dodecalactone are preferred, and γ-decalactone and γ-undecalactone are more preferred. These lactone compounds are components that have the aroma of fruits such as peaches, apricots, and coconuts. The lactone compounds may be used individually or in combination of two or more.

[0017] The content of the lactone compound represented by formula (I) in the epidermal keratinocyte proliferation promoter of the present invention is 0.0000001% to 10% by weight, and from the viewpoint of the effect of promoting epidermal keratinocyte proliferation, it is preferably 0.0000005% to 5% by weight, more preferably 0.000001% to 3% by weight, even more preferably 0.000005% to 2% by weight, and particularly preferably 0.00001% to 1% by weight. Furthermore, when used diluted, such as in bath additives, the content of the lactone compound can be adjusted taking into consideration the content after dilution. For example, in the case of bath additives, it is preferably 0.001% to 10% by weight, and more preferably 0.001% to 5% by weight. When two or more lactone compounds are used in combination, their total amount will fall within the above numerical range.

[0018] The pH of the epidermal keratinocyte proliferation promoter of the present invention is typically 3.0 to 8.0, and preferably 3.5 to 7.5. This pH can be adjusted, for example, by using a pH adjusting agent as described later.

[0019] The epidermal keratinocyte proliferation promoter of the present invention may consist solely of the above-mentioned lactone compound, or it may be formulated by combining the above-mentioned lactone compound with components necessary for formulation. When formulation, it can be made into any dosage form such as powder, granules, tablets, or liquid by conventional methods using pharmaceutically acceptable base materials, carriers, and other optional additives. The epidermal keratinocyte proliferation promoter of the present invention can be used as a topical preparation, ointment, patch, etc., and as described later, the epidermal keratinocyte proliferation promoter can also be used by incorporating it into other compositions such as skin topical compositions.

[0020] <Formulation of the epidermal keratinocyte proliferation-promoting agent of the present invention> The epidermal keratinocyte proliferation promoter of the present invention can be mixed with a base or carrier commonly used in cosmetics, pharmaceuticals, and quasi-drugs, and optionally with additives described later, according to conventional methods, and emulsified or solubilized as necessary to form various formulations.

[0021] (Base material, carrier) Examples of the above-mentioned bases or carriers include hydrocarbons such as liquid paraffin, squalane, petrolatum, gelling hydrocarbons (such as Plastibase), ozokerite, α-olefin oligomers, and light liquid paraffin; silicone oils such as methylpolysiloxane, highly polymerized methylpolysiloxane, cyclic silicones, alkyl-modified silicones, amino-modified silicones, polyether-modified silicones, polyglycerin-modified silicones, silicone-alkyl chain-comodified polyether-modified silicones, silicone-alkyl chain-comodified polyglycerin-modified silicones, polyether-modified branched silicones, polyglycerin-modified branched silicones, acrylic silicones, phenyl-modified silicones, and silicone resins; oils and fats such as coconut oil, olive oil, rice bran oil, and shea butter; waxes such as jojoba oil, miurose, candelilla wax, and lanolin; higher alcohols such as cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyldodecanol, isostearyl alcohol, phytosterols, and cholesterol; and cellulose derivatives such as ethylcellulose, hydroxypropylcellulose, and hydroxypropylmethylcellulose. Conductors; polyvinylpyrrolidone; carrageenan; polyvinyl butyrate; polyethylene glycol; dioxane; butylene glycol adipate polyester; esters such as diisopropyl adipate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, and pentaerythritol tetra-2-ethylhexanoate; polysaccharides such as dextrin and maltodextrin; vinyl polymers such as carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers; lower alcohols such as ethanol and isopropanol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether;Examples include water, etc.

[0022] In the epidermal keratinocyte proliferation promoter of the present invention, these bases or carriers may be used individually or in combination of two or more. Furthermore, the amounts used can be appropriately selected from a range known to those skilled in the art.

[0023] (Additives) The epidermal keratinocyte proliferation promoter of the present invention may contain known additives used in cosmetics, pharmaceuticals, and quasi-drugs, such as surfactants, stabilizers, antioxidants, colorants, pearlescent agents, dispersants, chelating agents, pH adjusters, preservatives, thickeners, and irritation reducers, to the extent that they do not impair the effects of the present invention. These additives may be used individually or in combination of two or more.

[0024] The above surfactants may be nonionic surfactants, cationic surfactants, anionic surfactants, amphoteric surfactants, etc., for example, sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan diglycerol penta-2-ethylhexyl sorbitan, sorbitan diglycerol tetra-2-ethylhexyl sorbitan; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80; polyoxyethylene monolauryl Examples include polyoxyethylene sorbitan fatty acid esters such as poly(20) sorbitan (polysorbate 20), polyoxyethylene(20) sorbitan monostearate (polysorbate 60), polyoxyethylene(20) sorbitan monooleate (polysorbate 80), and polyoxyethylene(20) sorbitan isostearate; polyoxyethylene monococonut oil fatty acid glyceryl; glycerin alkyl ethers; alkyl glucosides; polyoxyalkylene alkyl ethers such as polyoxyethylene cetyl ether; amines such as stearylamine and oleylamine; and silicone-based surfactants such as polyoxyethylene methylpolysiloxane copolymers, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone.

[0025] Examples of the above-mentioned stabilizers include sodium polyacrylate, dibutylhydroxytoluene, and butylhydroxyanisole.

[0026] Examples of the above-mentioned antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, and L-cysteine ​​hydrochloride.

[0027] Examples of the above-mentioned colorants include inorganic pigments and natural pigments.

[0028] Examples of the pearlescent luster imparting agents mentioned above include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.

[0029] Examples of the above-mentioned dispersants include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinylpyrrolidone, methyl vinyl ether / maleic anhydride crosslinked copolymer, and organic acids.

[0030] Examples of the chelating agents mentioned above include EDTA-disodium salt and EDTA-calcium-disodium salt.

[0031] Examples of the pH adjusting agents mentioned above include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.), and organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.).

[0032] Examples of the above-mentioned preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, and phenoxyethanol.

[0033] Examples of the above-mentioned thickening agents include vinyl-based thickening agents such as polyvinyl alcohol, polyvinylpyrrolidone, and carboxyvinyl polymer; cellulose-based thickening agents such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, and carboxyethylcellulose; guar gum, pectin, pullulan, gelatin, locust bean gum, carrageenan, agar, xanthan gum, alkyl acrylate methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, sodium chondroitin sulfate, hyaluronic acid, sodium hyaluronate, (hydroxyethyl acrylate / sodium acryloyldimethyltaurate) copolymer, and (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer.

[0034] Examples of the irritation-reducing agents mentioned above include licorice extract, sodium alginate, gum arabic, and polyvinylpyrrolidone.

[0035] (Formulation form) The formulation form of the epidermal keratinocyte proliferation promoter of the present invention is not particularly limited and can be found in the form of skincare products (lotions, emulsions, serums, creams, etc.), makeup products, makeup bases, body soaps, facial cleansers and other cleansing agents, shampoos, conditioners, dry shampoos, scalp care agents, hair mists, hair growth agents and other hair care agents, cleansing agents, wipe-off lotions, deodorants, antiperspirants, bath additives, ointments, liquids, suspensions, emulsifiers (emulsifiers and creams), gels, liniments, lotions, poultices, mists, aerosols, powders, granules, tablets (including effervescent tablets), solid soaps, etc. Of these, liquid to semi-solid formulation forms are preferred, and are particularly useful when applied to liquids, lotions, ointments, gels, and emulsifiers. These formulations can be manufactured by conventional methods, for example, the method described in the General Provisions of the 17th Revised Japanese Pharmacopoeia. It may also be used by impregnating a nonwoven fabric with it. The epidermal keratinocyte proliferation promoter of the present invention is particularly suitable for use as a topical formulation for anti-aging purposes.

[0036] [Skin cell turnover promoter] The skin turnover promoter of the present invention is characterized by containing a lactone compound represented by the above formula (I) as an active ingredient. By containing the above lactone compound, the skin turnover promoter of the present invention has the effect of promoting the proliferation of epidermal keratinocytes of the skin, thereby promoting skin turnover and promoting the metabolic function of the skin. It is believed that when skin turnover slows down due to aging or other causes, melanin excretion becomes poor, making it easier for pigmentation and dullness to occur. Furthermore, it is believed that when skin metabolism declines, the skin environment deteriorates, the balance of resident bacteria on the skin (including the scalp) is disrupted, and bacteria that cause odor increase, leading to the occurrence of age-related body odor, scalp odor, etc. Therefore, when skin turnover is promoted by the skin turnover promoter of the present invention, it is possible to suppress pigmentation and dullness and improve melanin excretion function, and it is expected that skin tone-up effects, improved skin transparency, and improved skin luster can be expected. Furthermore, it can prevent / improve skin problems such as fine wrinkles, loss of skin texture, loss of firmness, rough skin, and skin irritation, as well as age-related body odor and scalp odor. In other words, the skin turnover promoter of the present invention is suitably used to prevent and / or improve at least one symptom selected from the group consisting of fine wrinkles, dullness, loss of skin texture, loss of firmness, pigmentation, skin tone down, rough skin, skin irritation, age-related body odor, and scalp odor. The specific description of the skin turnover promoter of the present invention can be applied as is, by replacing the epidermal keratinocyte proliferation promoter with the skin turnover promoter in the description of the epidermal keratinocyte proliferation promoter of the present invention described above.

[0037] [Skin metabolism promoter] The skin metabolism promoter of the present invention is characterized by containing a lactone compound represented by the above formula (I) as an active ingredient. By containing the above lactone compound, the skin metabolism promoter of the present invention has the effect of promoting the proliferation of epidermal keratinocytes of the skin, thereby promoting skin turnover and promoting skin metabolic function. It is believed that when skin turnover slows down and skin metabolic function declines due to aging or other causes, melanin excretion becomes poor, making it easier for pigmentation and dullness to occur. Therefore, when skin metabolic function is promoted by the skin metabolism promoter of the present invention, it is possible to suppress pigmentation and dullness and improve melanin excretion function, and an effect of brightening skin tone, improving skin transparency, and improving skin luster can be expected. Furthermore, it is believed that when skin metabolism declines, the skin environment deteriorates, the balance of resident bacteria on the skin (including the scalp) is disrupted, and bacteria that cause odor increase, leading to the occurrence of age-related odor, scalp odor, etc. Furthermore, it can prevent / improve skin problems such as fine wrinkles, loss of skin texture, loss of firmness, rough skin, and skin irritation, as well as age-related body odor and scalp odor. In other words, the skin metabolism promoter of the present invention is suitably used to prevent and / or improve at least one symptom selected from the group consisting of fine wrinkles, dullness, loss of skin texture, loss of firmness, pigmentation, skin tone down, rough skin, skin irritation, age-related body odor, and scalp odor. The specific description of the skin metabolism promoter of the present invention can be applied as is, by replacing "epidermal keratinocyte proliferation promoter" with "skin metabolism promoter" in the description of the epidermal keratinocyte proliferation promoter of the present invention described above.

[0038] [Skin external composition] The epidermal keratinocyte proliferation promoter, skin turnover promoter, and skin metabolism promoter of the present invention can also be incorporated into other compositions and used as topical skin compositions. The present invention also includes topical skin compositions containing the above-mentioned epidermal keratinocyte proliferation promoter, skin turnover promoter, or skin metabolism promoter of the present invention. Because the topical skin compositions of the present invention contain the epidermal keratinocyte proliferation promoter, skin turnover promoter, or skin metabolism promoter of the present invention, they exhibit epidermal keratinocyte proliferation promoting effects, skin turnover promoting effects, and skin metabolism promoting effects, and are therefore suitably used for the prevention and / or improvement of at least one symptom selected from the group consisting of fine wrinkles, dullness, loss of texture, loss of firmness, pigmentation, skin tone down, rough skin, skin irritation, age-related body odor, and scalp odor.

[0039] In addition to the lactone compound represented by formula (I) above, which is an essential component of the epidermal keratinocyte proliferation promoter, skin turnover promoter, and skin metabolism promoter of the present invention, the topical skin composition of the present invention may also contain the following optional components, to the extent that they do not impair the effects of the present invention.

[0040] Optional components that the topical skin composition of the present invention may contain in addition to the essential components mentioned above include, for example, anti-inflammatory agents, cooling agents, bactericides, vitamins, organic acids, moisturizing components, polyhydric alcohols, scrubbing agents, UV absorbing components, UV scattering components, astringent components, peptides or their derivatives, amino acids or their derivatives, cleansing components, keratin softening components, cell activating components (excluding lactones in the present invention), anti-aging components (excluding lactones in the present invention), blood circulation promoting components, whitening components, powders, and the like. In the topical skin composition of the present invention, each of these components may be used individually or in combination of two or more.

[0041] Examples of anti-inflammatory agents include allantoin and its derivatives, glycyrrhetinic acid and its derivatives, glycyrrhizic acid and its derivatives, salicylic acid derivatives, aminocaproic acid, azulene and its derivatives, zinc oxide, tocopherol acetate, hydrocortisone, prednisolone, and salts thereof. Among these, allantoin, allantoin chlorohydroxyaluminum, allantoin dihydroxyaluminum, glycyrrhetinic acid, glycyrrhizic acid, stearyl glycyrrhetinate, glycol salicylate, methyl salicylate, epsilon-aminocaproic acid, azulene, guaiazulene, and salts thereof are preferred. Here, "derivative" refers to esters, ethers, alkylates, glycosides, etc., of the compounds described. Here, "salt" refers to, for example, salts of mineral acids such as sulfuric acid, hydrochloric acid, or phosphoric acid, salts of organic acids such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts, etc.

[0042] Examples of the cooling agents mentioned above include terpenes such as menthol, camphor, borneol, geraniol, cineole, anethole, limonene, and eugenol (these may be d-isomers, l-isomers, or dl-isomers); and essential oils such as eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose oil, and turpentine oil.

[0043] Examples of the above-mentioned disinfectants include isopropylmethylphenol, chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, triclocarban, triclosan, photosensitizer 101, photosensitizer 201, parabens, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, piroctoolamine, miconazole, and the like.

[0044] The above vitamins may be either water-soluble or fat-soluble vitamins, for example, vitamin B6 compounds such as pyridoxine, pyridoxal, pyridoxamine, 5'-pyridoxal phosphate, and their salts (e.g., pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, pyridoxamine hydrochloride); pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-panthesine, D-pantethine, coenzyme A, pantothenyl ethyl ether, and their salts; nicotinic acid, nicotine Nicotinic acids such as dl-α-tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, 1-(4-methylphenyl)ethyl nicotinate, nicotinamide, and salts thereof; γ-oryzanol, thiamine, dibenzoylthiamine, thiamine cetyl, thiamine monophosphate, thiamine diphosphate, thiamine triphosphate, and salts thereof (e.g., dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine Vitamin B1 compounds such as nitrates, thiamine monophosphates, thiamine lysine salts, thiamine triphosphates, thiamine monophosphate phosphates, thiamine diphosphate hydrochloride, thiamine triphosphate monophosphates; Vitamin B2 compounds such as riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinate, and their salts; and biotin, biocitin, and their salts. Vitamins such as otin; folic acid derivatives such as folic acid, pteroylglutamic acid, and their salts; vitamin B12 derivatives such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin, and their salts; water-soluble vitamin C derivatives such as ascorbic acid, dehydroascorbic acid, ascorbic acid phosphate, ascorbic acid-2-glucoside, 3-O-ethylascorbic acid, and their salts (e.g., sodium ascorbate, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate);Examples include vitamin E derivatives such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, and dl-α-tocopherol calcium succinate; oil-soluble vitamin C derivatives such as ascorbigen-A, ascorbic acid stearate, ascorbic acid palmitate, L-ascorbyl dipalmitate, and tetra-2-hexyldecanoate ascorbyl; vitamin D derivatives such as ergocalciferol and cholecalciferol; vitamin K derivatives such as phylloquinone and phalnoquinone; and vitamin-like factors such as ferulic acid.

[0045] Examples of the above-mentioned organic acids include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid, lactic acid, and salts thereof. Examples of salts include salts of mineral acids such as sulfuric acid, hydrochloric acid, or phosphoric acid, salts of organic acids such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metal salts, and ammonium salts.

[0046] Examples of the above-mentioned moisturizing ingredients include diglycerin trehalose; high molecular weight compounds such as sodium hyaluronate, heparinoid, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, and chitosan; amino acids such as glycine, aspartic acid, and arginine; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidone carboxylate; lipids such as ceramide, cholesterol, and phospholipids; and plant extracts such as chamomile extract, witch hazel extract, tea extract, and perilla extract.

[0047] The polyhydric alcohols mentioned above are preferably those having 2 to 10 carbon atoms, and examples include glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, 1,3-butylene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, hexanediol, octanediol, decanediol, neopentyl glycol, and the like.

[0048] Examples of the scrubbing agents mentioned above include apricot kernel powder, almond shell powder, apricot kernel powder, sodium chloride granules, olive kernel powder, dried seawater granules, candelilla wax, walnut shell powder, cherry kernel powder, coral powder, charcoal powder, hazelnut shell powder, polyethylene powder, anhydrous silicic acid, and the like.

[0049] Examples of the above-mentioned UV-absorbing components include octyl triazone, octyl dimethoxybenzylidene dioxoimidazolidine propionate, 2-ethylhexyl paramethoxycinnamate, and phenylbenzimidazole sulfonic acid.

[0050] Examples of the above-mentioned ultraviolet scattering components include inorganic compounds such as hydrated silica, zinc silicate, cerium silicate, titanium silicate, zirconium oxide, cerium oxide, titanium oxide, iron oxide, and anhydrous silica; these inorganic compounds coated with inorganic powders such as hydrated silica, aluminum hydroxide, mica, or talc; compounded with resin powders such as polyamide, polyethylene, polyester, polystyrene, or nylon; and those treated with silicone oil or fatty acid aluminum salts.

[0051] Examples of the astringent components mentioned above include zinc sulfate, aluminum chloride, zinc sulfocarbonate, and tannic acid.

[0052] Examples of the peptides or their derivatives include keratin-degrading peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin-degrading peptides, collagen-degrading peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degrading peptides, conchiolin-degrading peptides, hydrolyzed conchiolin, silk protein-degrading peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy protein-degrading peptides, hydrolyzed soy protein, wheat protein, wheat protein-degrading peptides, hydrolyzed wheat protein, casein-degrading peptides, acylated peptides (palmitoyl oligopeptides, palmitoyl pentapeptides, palmitoyl tetrapeptides, etc.).

[0053] Examples of the above amino acids or their derivatives include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, and the like.

[0054] Examples of the above-mentioned cleansing ingredients include soaps selected from alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate, or potassium stearate, alkanolamide salts, or amino acid salts; amino acid-based surfactants such as sodium cocoyl glutamate and sodium cocoyl methyl taurate; ether sulfate salts such as sodium laureth sulfate; ether carboxylate salts such as sodium lauryl ether acetate; sulfosuccinate salts such as sodium alkyl sulfosuccinate; fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide and coconut oil fatty acid diethanolamide; monoalkyl phosphate salts such as sodium lauryl phosphate and sodium polyoxyethylene lauryl ether phosphate; betaine-type amphoteric surfactants such as coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, lauryl dimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl hydroxysulfobetaine, and lauroylamide ethyl hydroxyethyl carboxymethyl betaine hydroxypropyl sodium phosphate; and amino acid-type amphoteric surfactants such as sodium laurylaminopropionate.

[0055] Examples of the above-mentioned exfoliating ingredients include lactic acid, salicylic acid, gluconic acid, citric acid, malic acid, fruit acid, phytic acid, urea, and sulfur.

[0056] Examples of the cell-activating components mentioned above include amino acids such as γ-aminobutyric acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acid; α-hydroxy acids such as glycolic acid and lactic acid; and tannins, flavonoids, saponins, and photosensitizer 301.

[0057] Examples of the anti-aging ingredients mentioned above include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, and N-methyl-L-serine.

[0058] The above-mentioned blood circulation-promoting components include those derived from plants (for example, Panax ginseng, Angelica keiskei, Arnica, Ginkgo biloba, Fennel, Ophiopogon japonicus, Watercress, Chamomile, Roman chamomile, Carrot, Gentian, Burdock, Rice, Hawthorn, Shiitake mushroom, Ginger, Hawthorn, Juniper, Cnidium officinale, Swertia japonica, Thyme, Clove, Citrus unshiu peel, Chili pepper, Angelica acutiloba, Prunus serrulata, Carrot, Garlic, Butcher's broom, Grape, Peony, Horse chestnut, Melissa, Yuzu, Coix seed, Mugwort, Rosemary, Rosehip, Citrus unshiu peel, Angelica acutiloba, Prunus serrulata, Peach, Apricot, Walnut, Corn, etc.); acetylcholine, ichthammol, Cantharis tincture, gamma-oryzanol, cepharanthine, trazoline, tocopherol nicotinate, glucosyl hesperidin, etc.

[0059] Examples of the above-mentioned whitening ingredients include tocopherol and tranexamic acid.

[0060] Examples of the above powder components include aluminum starch octenyl succinate (aluminum starch octenyl succinate), talc, corn starch, magnesium hydroxide, anhydrous silicic acid, light anhydrous silicic acid, mica, hydroxyapatite, zinc oxide, titanium dioxide, nylon powder, and charcoal.

[0061] (pH) The pH of the topical skin composition of the present invention is typically 3.0 to 8.0, and preferably 3.5 to 7.5. This pH can be adjusted, for example, by using the pH adjusting agent described above.

[0062] <Method for producing a topical skin composition> The method for producing the topical composition of the present invention is not particularly limited. It can be produced by conventional methods by appropriately selecting and blending an epidermal keratinocyte proliferation promoter, a skin turnover promoter, or a skin metabolism promoter containing the lactone compound represented by formula (I) above, which is an essential component, and various components necessary for producing the topical skin composition (the above optional components, bases or carriers, additives, etc.). For details on the above bases or carriers and additives, please refer to the description in the section on skin keratinocyte proliferation promoters.

[0063] <Uses of topical skin compositions> The topical skin composition of the present invention contains the epidermal keratinocyte proliferation promoter, skin turnover promoter, or skin metabolism promoter of the present invention, and therefore exhibits the effects of promoting epidermal keratinocyte proliferation, promoting skin turnover, and promoting skin metabolism. It is therefore suitably used for the prevention and / or improvement of at least one symptom selected from the group consisting of fine wrinkles, dullness, loss of skin texture, loss of firmness, pigmentation, skin tone down, rough skin, skin irritation, age-related body odor, and scalp odor. The topical skin compositions of the present invention used for such purposes can be used, for example, as skincare products (lotions, emulsions, serums, creams, etc.), makeup products, makeup bases, cleansing agents such as body soaps and facial washes, hair care products such as shampoos, conditioners, dry shampoos, scalp care agents, hair mists, hair growth agents, hair restoration agents, cleansing agents, deodorants, antiperspirants, ointments, liquids, suspensions, emulsifiers (emulsions and creams), gels, liniments, lotions, poultices, mists, aerosols, powders, granules, solid soaps, etc. They are particularly suitable for use as topical skin compositions for anti-aging purposes.

[0064] [Methods to promote epidermal keratinocyte proliferation, methods to promote skin turnover, methods to promote skin metabolism] The present invention also includes a method for promoting epidermal keratinocyte proliferation, a method for promoting skin turnover, and a method for promoting skin metabolism, characterized by using a lactone compound represented by the above formula (I). The above lactone compound has the effect of promoting the proliferation of epidermal keratinocytes of the skin, thereby promoting skin turnover and restoring the metabolic function of the skin. It is believed that when skin turnover slows down due to aging or other causes, melanin excretion becomes poor, making it easier for pigmentation and dullness to occur. Furthermore, it is believed that when skin metabolism declines, the skin environment deteriorates, the balance of resident bacteria on the skin (including the scalp) is disrupted, and bacteria that cause odor increase, leading to the occurrence of age-related body odor, scalp odor, etc. Therefore, when skin turnover is promoted by the method of the present invention, it is possible to suppress pigmentation and dullness, improve melanin excretion function, and expect skin tone-up effects, improved skin transparency, and improved skin luster. Furthermore, it can prevent / improve skin problems such as fine wrinkles, loss of skin texture, loss of firmness, rough skin, and skin irritation, as well as age-related body odor and scalp odor. In other words, the epidermal keratinocyte proliferation promoting method, skin turnover promoting method, and skin metabolism promoting method of the present invention are suitably used to prevent and / or improve at least one symptom selected from the group consisting of fine wrinkles, dullness, loss of skin texture, loss of firmness, pigmentation, skin tone down, rough skin, skin irritation, age-related body odor, and scalp odor.

[0065] The method for promoting epidermal keratinocyte proliferation of the present invention can be specifically realized by using the epidermal keratinocyte proliferation promoting agent of the present invention described above, or a topical skin composition containing the same. Furthermore, the method for promoting skin turnover of the present invention can be specifically realized by using the skin turnover promoting agent of the present invention described above, or a topical skin composition containing the same. In addition, the method for promoting skin metabolism of the present invention can be specifically realized by using the skin metabolism promoting agent of the present invention described above, or a topical skin composition containing the same. [Examples]

[0066] The present invention will be described in more detail below with reference to examples, but the present invention is not limited thereto.

[0067] [Human epidermal keratinocyte proliferation test] After activating normal human epidermal keratinocytes (NHEK, Kurabo), seed them at the recommended seeding density of 75 cm². 2 Cells were seeded in a flask (FALCON) and cultured for 3 days at 37°C under 5% CO2 conditions. Afterward, cells were harvested using 0.025% Trypsin-EDTA (Kurabo) and seeded at the set cell density on various plates for culture, which were then used in the experiment. NHEK was seeded at 5,000 cells / 200 μL / well in a 96-well black plate (Corning). After 24 hours of culture, the culture medium was aspirated and removed. Various lactones, diluted to 0.000001% in the culture medium, were added at a rate of 200 μL / well, and cultured for another 3 days. After culture, the culture medium was removed, Hoechst 33342 (DOJINDO) diluted to 1 / 1,000 was added, and after a 5-minute reaction under light shielding, the cell count was determined by measuring the stained nuclei using ImageXpress (Molecular Device). The results are shown in Figure 1.

[0068] As shown in Figure 1, the addition of γ-decalactone and γ-undecalactone to the culture medium promoted the proliferation of human epidermal keratinocytes. Although the data is not shown, it was confirmed that the proliferation-promoting effect on human epidermal keratinocytes was also obtained at concentrations of 0.0000001% and 0.00000001% of each lactone.

[0069] The following are examples of formulations for the topical compositions of the present invention. The numerical values ​​(%) for each lactone listed in Table 1 represent the final concentration (weight %) of the entire composition when the respective combination is used in each formulation example.

[0070] <Example of formulation 1: Body soap> Any of the lactone compound combinations listed in Table 1 Lauric acid 5% by weight Palmitic acid 5% by weight Stearic acid 5% by weight Potassium hydroxide (appropriate amount) Glycerin 5% by weight Dibutylhydroxytoluene 0.01% by weight Disodium EDTA 0.05% by weight Phenoxyethanol 0.3% by weight Benzalkonium chloride 0.1% by weight Sodium laureth sulfate 5% by weight Coconut oil fatty acid amidopropyl betaine 5% by weight Polyquaternium-10 0.5% by weight Polyquaternium-7 0.2% by weight Kaolin 0.5% by weight Charcoal 0.05% by weight Magnesium ascorbate phosphate 0.5% by weight Hydroxyethylcellulose 0.3% by weight water remainder Total 100% by weight

[0071] [Table 1]

[0072] <Example of formulation 2: Foaming body wash> Any of the lactone compound combinations listed in Table 1 PEG-80 sorbitan laurate 5% by weight Disodium cocoyl glutamate 4% by weight Sodium cocoyl glycine 2% by weight Sorbitol 5% by weight Cocoyl methyl taurate sodium 2% by weight Appropriate amount of citric acid Disodium EDTA 0.05% by weight Cocamide DEA 1% by weight Sodium cocoamphoacetate 3% by weight Polyquaternium-7 0.05% by weight Dipotassium glycyrrhizinate 0.3% by weight water remainder Total 100% by weight

[0073] <Example of formulation 3: Facial cleanser> Any of the lactone compound combinations listed in Table 1 Lauric acid 5% by weight Myristic acid 10% by weight Palmitic acid 7% by weight Stearic acid 7% by weight Potassium hydroxide (appropriate amount) Butylene glycol 5% by weight Glycerin 5% by weight Tocopherol 0.05% by weight Disodium EDTA 0.05% by weight Phenoxyethanol 0.3% by weight Salicylic acid 0.2% by weight Coconut oil fatty acid amidopropyl betaine 5% by weight Polyquaternium-10 0.3% by weight Polyquaternium-7 0.1% by weight l-Menthol 0.3% by weight Fragrance 0.2% by weight water remainder Total 100% by weight

[0074] <Example of formulation 4: Shampoo> Any of the lactone compound combinations listed in Table 1 Sodium laureth sulfate 30% by weight Triethanolamine Cocoyl Glutamate 5% by weight Sodium lauroyl methylalanine 5% by weight Lauramidopropyl hydroxysultaine 5% by weight Appropriate amount of citric acid Dimethicone 0.3% by weight Methylparaben 0.2% by weight Disodium edetate 0.1% by weight Polyquaternium-10 0.5% by weight Polyquaternium-39 0.1% by weight Polyquaternium-7 0.1% by weight Fragrance 0.8% by weight water remainder Total 100% by weight

[0075] <Example of formulation 5: Shampoo> Any of the lactone compound combinations listed in Table 1 Sodium olefin (C14-16) sulfonate 15% by weight POE Lauryl Ether Sodium Acetate 5% by weight Coconut oil fatty acid diethanolamide 5% by weight Coconut oil fatty acid TEA solution 5% by weight Coconut oil fatty acid amidopropyl betaine solution 5% by weight Appropriate amount of citric acid Disodium edetate 0.1% by weight Benzalkonium chloride 1% by weight Polyquaternium-10 0.6% by weight Polyquaternium-7 0.1% by weight Fragrance 0.5% by weight water remainder Total 100% by weight

[0076] <Example of formulation 6: Hair conditioner> Any of the lactone compound combinations listed in Table 1 Glycerin 5% by weight Hyaluronic acid 0.1% by weight Dipotassium glycyrrhizinate 0.1% by weight Squalane 0.1% by weight Stearyltrimethylammonium chloride 4% by weight Polyquaternium-10 0.5% by weight Cetanol 2% by weight POE-Monostearyl Glyceryl Ether 1% by weight Dibutylhydroxytoluene 0.01% by weight Phenoxyethanol 0.3% by weight EDTA-2Na 0.05% by weight l-Menthol 0.2% by weight Fragrance 0.3% by weight water remainder Total 100% by weight

[0077] <Example of formulation 7: Hair treatment> Any of the lactone compound combinations listed in Table 1 Propylene glycol 5% by weight Acetylated hyaluronic acid 0.01% by weight Allantoin 0.3% by weight Pentasliette tetra-2-ethylhexanoate 1% by weight Cetyltrimethylammonium bromide 2.5% by weight Polyquaternium-7 0.1% by weight Cetostearyl alcohol 2% by weight Stearyl alcohol 2% by weight POE-hydrogenated castor oil 1% by weight Dibutylhydroxytoluene 0.01% by weight Methyl parahydroxybenzoate 0.3% by weight EDTA-2Na 0.05% by weight Fragrance 0.5% by weight water remainder Total 100% by weight

[0078] <Example of formulation 8: Hair Essence> Any of the lactone compound combinations listed in Table 1 Butylene glycol 5% by weight Hydrolyzed hyaluronic acid 0.1% by weight Epsilon-aminocaproic acid 0.05% by weight Alkyltrimethylammonium chloride 0.7% by weight O-[2-hydroxy-3-(trimethylammonio) chloride] Propyl guar gum 0.5% by weight Diethylene glycol monoethyl ether 2% by weight POE-Sorbitan Monoisostearate 0.8% by weight Ethanol 20% by weight Phenoxyethanol 0.3% by weight Fragrance 0.1% by weight water remainder Total 100% by weight

[0079] <Example of formulation 9: Hair mist> Any of the lactone compound combinations listed in Table 1 Hydrolyzed collagen 1% by weight Butylene glycol 5% by weight Hydrolyzed hyaluronic acid 0.1% by weight Dipotassium glycyrrhizinate 0.05% by weight Polyquaternium-51 0.5% by weight Liquid paraffin 0.5% by weight Monoisostearyl glyceryl ether 1% by weight Ethanol 30% by weight Propyl parahydroxybenzoate 0.3% by weight Fragrance 0.3% by weight water remainder Total 100% by weight

[0080] <Example of formulation 10: Antiperspirant cream> Any of the lactone compound combinations listed in Table 1 Benzalkonium chloride 0.07% by weight Isopropylmethylphenol 0.07% by weight Chlorohydroxyaluminum 4% by weight Cyclopentasiloxane 25% by weight Alkyl polyacrylate 6% by weight POE·POP dimethicone copolymer 3.5% by weight Dipotassium glycyrrhizinate 0.05% by weight Concentrated glycerin 7% by weight Isononyl isononanoate 5% by weight Sorbitan isostearate 5% by weight l-Menthol 0.5% by weight Fragrance 0.3% by weight water remainder Total 100% by weight

[0081] <Example of formulation 11: Antiperspirant gel> Any of the lactone compound combinations listed in Table 1 Benzalkonium chloride 0.06% by weight Isopropylmethylphenol 0.05% by weight Chlorohydroxyaluminum 8% by weight Magnesium aluminometasilicate 0.5% by weight Dipropylene glycol 10% by weight Polyoxypropylene glycol 0.5% by weight Hydroxypropyl methylcellulose 0.5% by weight Xanthan gum 0.5% by weight Ethanol 10% by weight l-Menthol 0.3% by weight l-Menthyl glyceryl ether 0.3% by weight Peppermint oil 0.3% by weight Fragrance 0.3% by weight water remainder Total 100% by weight

[0082] <Example of formulation 12: Antiperspirant spray> Any of the lactone compound combinations listed in Table 1 Isopropylmethylphenol 0.1% by weight Zinc paraphenolsulfonate 1% by weight Diethyl sebacate 4% by weight Talc 5% by weight Nylon powder 1% by weight Fragrance 0.5% by weight Ethanol 15% by weight Dimethyl ether residue Total 100% by weight

[0083] <Example of formulation 13: Antiperspirant roll-on> Any of the lactone compound combinations listed in Table 1 Benzalkonium chloride 0.06% by weight Isopropylmethylphenol 0.06% by weight Zinc paraphenolsulfonate 5% by weight Butylene glycol 5% by weight Chlorohydroxyaluminum 0.05% by weight Talc 3% by weight Nylon powder 0.5% by weight Cetyltrimethylammonium bromide solution 1% by weight Hydroxypropyl methylcellulose 0.5% by weight l-Menthol 0.1% by weight Fragrance 0.3% by weight Water 40% by weight Ethanol remaining Total 100% by weight

[0084] <Example of formulation 14: Antiperspirant mist> Any of the lactone compound combinations listed in Table 1 Benzalkonium chloride 0.05% by weight Isopropylmethylphenol 0.06% by weight Zinc paraphenolsulfonate 1% by weight Butylene glycol 5% by weight Chlorohydroxyaluminum 0.02% by weight Sericite complex 0.3% by weight Cetyltrimethylammonium bromide solution 0.5% by weight l-Menthol 0.3% by weight Fragrance 0.3% by weight Water 10% by weight Ethanol remaining Total 100% by weight

[0085] <Example of formulation 15: Antiperspirant stick> Any of the lactone compound combinations listed in Table 1 Benzalkonium chloride 0.055% by weight Isopropylmethylphenol 0.05% by weight Chlorohydroxyaluminum 5% by weight Polyethylene wax 5% by weight Microcrystalline wax 5% by weight Glyceryl monostearate 3% by weight Isononyl isononanoate 5% by weight Talc 12% by weight Methylpolysiloxane 2% by weight Decamethylpentasiloxane 0.3% by weight Silylated anhydrous silicic acid 15% by weight Cetanol 2% by weight Hydroxyapatite 0.3% by weight Cetyltrimethylammonium bromide solution 0.5% by weight l-Menthol 0.5% by weight Zinc oxide 0.3% by weight Fragrance 0.3% by weight Stearyl alcohol remaining Total 100% by weight

[0086] <Example of formulation 16: Cleansing lotion> Any of the lactone compound combinations listed in Table 1 Ethanol 15% by weight Polyoxyethylene polyoxypropylene decyltetradecyl Ether 1% by weight Hydrolyzed jojoba esters 0.01% by weight Methylsiloxane network polymer 0.01% by weight Magnesium ascorbate phosphate 0.3% by weight Fragrance 0.05% by weight Parabens 0.3% by weight Appropriate amount of citric acid Purified water remainder Total 100% by weight

[0087] <Example of formulation 17: Deodorant sheet> Any of the lactone compound combinations listed in Table 1 Isopropylmethylphenol 0.05% by weight Zinc paraphenolsulfonate 1% by weight Ethanol 30% by weight Cetyltrimethylammonium bromide solution 0.5% by weight Butylene glycol 1% by weight Sericite complex 0.1% by weight Kaolin 0.3% by weight Phenoxyethanol 0.1% by weight Fragrance 0.1% by weight Appropriate amount of citric acid Purified water remainder Total 100% by weight

[0088] <Example of formulation 18: Bath Milk> Any of the lactone compound combinations listed in Table 1 Polysorbate 20 12% by weight Polysorbate 80 3% by weight Octyldodecanol 5% by weight Sunflower oil 2% by weight Pigments / Fragrances Appropriate amount Remaining mineral oil Total 100% by weight

[0089] <Example of formulation 19: Powdered bath additive> Any of the lactone compound combinations listed in Table 1 Sodium bicarbonate 20% by weight Sodium sulfate 20% by weight Sodium chloride 5% by weight Pigments / Fragrances Appropriate amount Sodium carbonate residue Total 100% by weight

[0090] <Example of formulation 20: Tablet-type bath additive> Any of the lactone compound combinations listed in Table 1 Sodium bicarbonate 10% by weight Sodium carbonate 13% by weight Succinic acid 25% by weight Polyethylene glycol 1% by weight Pigments / Fragrances Appropriate amount Sodium sulfate remainder Total 100% by weight [Industrial applicability]

[0091] According to the present invention, it is possible to provide an epidermal keratinocyte proliferation promoter, a skin turnover promoter, and a skin metabolism promoter that can prevent / improve the decline in skin metabolic function, the decrease in the rate of epidermal turnover, and the deterioration of the skin environment caused by these factors, which occur due to various factors such as aging and damage from ultraviolet rays. In doing so, it is possible to prevent skin aging phenomena such as fine wrinkles, dullness, and pigmentation, as well as age-related odor and head odor (including scalp odor), which are thought to be caused in part by an imbalance of resident bacteria due to the deterioration of the skin environment. These promoters of the present invention have the effect of promoting epidermal keratinocyte proliferation, promoting skin turnover, restoring the metabolic function of the skin, or preventing and / or improving at least one symptom selected from the group consisting of fine wrinkles, dullness, loss of texture, loss of firmness, pigmentation, skin tone down, rough skin, skin irritation, age-related body odor, and head odor (including scalp odor). Therefore, they are suitably used in topical skin compositions such as cosmetics and quasi-drugs that are expected to have such effects.

Claims

1. An epidermal keratinocyte proliferation promoter characterized by containing a lactone compound represented by the following formula (I) as an active ingredient, used to prevent and / or improve at least one symptom selected from the group consisting of dullness, pigmentation, and skin tone down, which can be prevented and / or improved by promoting the proliferation of epidermal keratinocytes with the lactone. 【Transformation 8】 (In the formula, R is an alkyl group having 2 to 9 carbon atoms.)

2. A skin turnover promoter characterized by containing a lactone compound represented by the following formula (I) as an active ingredient, used to prevent and / or improve at least one symptom selected from the group consisting of dullness, pigmentation, and skin tone down, which can be prevented and / or improved by promoting skin turnover with the lactone. 【Chemistry 9】 (In the formula, R is an alkyl group having 2 to 9 carbon atoms.)

3. A skin metabolism promoter characterized by containing a lactone compound represented by the following formula (I) as an active ingredient, and used to prevent and / or improve at least one symptom selected from the group consisting of dullness, pigmentation, and skin tone down, which can be prevented and / or improved by promoting skin metabolism with the lactone. 【Chemistry 10】 (In the formula, R is an alkyl group having 2 to 9 carbon atoms.)

4. An accelerator for external use, according to any one of claims 1 to 3.

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