Topical skin components

Abstract

To provide ingredients for topical skin compositions, which are naturally occurring products derived from plants having excellent biosafety, and demonstrate an effect of normalizing skin turnover and barrier function.SOLUTION: The active ingredient of the invention is an extract of Prunus armeniaca Linne var anus Maximowicz or Prunus armeniaca Linne of the genus Prunus of the family Rosaceae.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a composition for normalizing skin turnover and improving skin barrier function, which comprises a plant extract as an active ingredient. Background Art

[0002] When the human epidermis functions normally, the generation of new cells in the basal layer and the shedding of old corneocytes from the stratum corneum are maintained in a constant balance (skin turnover functions normally). It is known that this epidermal turnover fails to function normally due to internal factors such as aging, as well as external factors such as damage to cells and tissues caused by reactive oxygen species induced by chemical substances (nitrogen compounds, sulfur compounds, etc.) contained in sunlight (ultraviolet rays), exhaust gas and the like, dryness or inflammation. In addition, it is also suggested that if skin turnover does not function normally, the skin barrier function is also reduced, leading to the progression of skin dryness and aging.

[0003] Conventionally, γ-aminobutyric acid, diisopropylamine dichloroacetate, hydroxycarboxylic acid and the like have been proposed as components suggested to normalize skin turnover, but there are problems in terms of skin safety and effectiveness, and skin turnover improving agents and skin barrier function improving agents excellent in skin safety and effectiveness are demanded. Disclosure of the Invention Problems to be Solved by the Invention

[0004] As a result of investigations in view of the problems of the above conventional art, the present inventors have found that an extract of apricot (Prunus armeniaca Linne var anus Maximowicz) or common apricot (Prunus armeniaca Linne) belonging to the genus Prunus of the family Rosaceae improves the skin barrier function and promotes normal skin turnover. Furthermore, the present inventors have also found that the combination of the extract of apricot or common apricot and an asparagus extract further enhances the skin turnover improving effect and the skin barrier function.

[0005] Conventionally, topical skin preparations containing apricot extract from the genus Prunus of the Rosaceae family have been proposed, including scalp skin preparations (Patent Document 1), protease inhibitors (Patent Document 2), bath preparations (Patent Document 3), anti-allergic agents (Patent Document 4), and topical skin preparations for preventing and improving skin damage caused by external environmental factors such as ultraviolet rays and chemical substances (Patent Document 5).

[0006] [Patent Document 1] Japanese Patent Application Publication No. 03-188013 [Patent Document 2] Japanese Patent Application Publication No. 10-338642 [Patent Document 3] Japanese Patent Publication No. 2000-186031 [Patent Document 4] Japanese Patent Publication No. 2001-064192 [Patent Document 5] Japanese Patent Publication No. 2014-221754 [Means for solving the problem]

[0007] The present invention is a composition for normalizing skin cell turnover, containing an extract of apricot (Prunus armeniaca Linne varanus Maximowicz) or Japanese apricot (Prunus armeniaca Linne), both belonging to the genus Prunus in the family Rosaceae, as an active ingredient. Furthermore, the present invention relates to a composition for normalizing skin barrier function, comprising an extract of apricot or Japanese apricot as an active ingredient. Furthermore, the composition of the present invention may be used in combination with white asparagus extract. [Effects of the Invention]

[0008] According to the present invention, it is possible to provide a highly safe composition for improving skin turnover, which contains an extract of apricot or Japanese apricot, a plant belonging to the genus Prunus in the Rosaceae family, as an active ingredient. Furthermore, by using apricot or Japanese apricot extract in combination with white asparagus extract, it is possible to provide a topical skin composition that further enhances the skin turnover improving effect and skin barrier function. [Modes for carrying out the invention]

[0009] Preferred embodiments of the present invention will be described in detail below. The extract material used in this invention is apricot (Prunus armeniaca Linne var anus Maximowicz) or Japanese apricot (Prunus armeniaca Linne) of the genus Prunus in the family Rosaceae, and any variety (variety, subspecies, or hybrid) may be used. Alternatively, it may be plum (Prunus salicina) or Japanese apricot (Prunus mume), which are closely related plants to the apricot.

[0010] The materials used in this invention may include the whole plant, fruit, peel, leaves, flowers, stems, seeds, roots, etc., of apricots, Japanese apricots, plums, or Japanese apricots, but the fruit or the whole plant including the fruit is preferred. The harvesting time and size of the parts of the apricots, Japanese apricots, plums, or Japanese apricots used are not particularly limited, and any size and harvesting time may be used.

[0011] To prepare the extract, first, the parts of apricots, Japanese apricots, plums, or Japanese apricots used (e.g., the fruit) are washed with water if necessary to remove foreign matter. Then, they are either left as is or dried, and if necessary, finely chopped, crushed, or made into a paste, and then brought into contact with the extraction solvent for extraction. Extraction can be carried out by bringing the material into contact with the extraction solvent according to conventional methods such as immersion, but supercritical fluid extraction or steam distillation can also be used.

[0012] Examples of extraction solvents include water; lower alcohols such as methanol, ethanol, and propanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin; esters such as ethyl acetate, butyl acetate, and methyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; and hydrocarbon solvents such as n-hexane, toluene, and chloroform. These can be used individually or in combination of two or more.

[0013] Among these extraction solvents, hydrophilic solvents such as water, lower alcohols, or polyhydric alcohols are preferred in the present invention because they can be widely applied to compositions for topical use on the skin. Preferred examples of using these hydrophilic solvents include, for example, the use of water, lower alcohols (especially ethanol), or polyhydric alcohols (especially 1,3-butylene glycol, glycerin) alone, or the use of a mixed solvent of water and lower alcohols (especially ethanol), or a mixed solvent of water and polyhydric alcohols (especially 1,3-butylene glycol, glycerin), but water alone or a mixed solvent of water and 1,3-butylene glycol are particularly preferred.

[0014] When using a mixed solvent, the mixing ratio is preferably in the range of 1:1 to 20:1 by volume (hereinafter the same) for a mixed solvent of water and 1,3-butylene glycol, 1:1 to 25:1 for a mixed solvent of water and ethanol, and 1:1 to 20:1 for a mixed solvent of water and glycerin.

[0015] Furthermore, the weight ratio of apricot material to extraction solvent is preferably in the range of 1:50 to 50:1, and more preferably in the range of 1:1 to 1:35.

[0016] In preparing the extract, the pH is not particularly limited, but in general, it is preferably in the range of 3 to 9. In this sense, if necessary, an alkaline adjuster such as sodium hydroxide, sodium carbonate, potassium hydroxide, or an acidic adjuster such as citric acid, hydrochloric acid, phosphoric acid, sulfuric acid may be added to the aforementioned extraction solvent to adjust to the desired pH.

[0017] Extraction conditions such as extraction temperature and extraction time vary depending on the type of solvent used and the pH. For example, when water, 1,3-butylene glycol, or a mixed solution of water and 1,3-butylene glycol is used as the solvent, the extraction temperature is preferably in the range of 0°C to 90°C, more preferably in the range of 0°C to 80°C, and the extraction time is preferably 1 to 168 hours (1 hour to 1 week), more preferably in the range of 1 to 120 hours (1 hour to 5 days).

[0018] Prior to or in parallel with the extraction treatment of the present invention, apricots may be subjected to a hydrolysis treatment as needed. This may improve the storage stability and the like of the apricot, common apricot, Japanese plum, or Japanese apricot extract, enabling more effective utilization of the extract as a compounding component of the external skin composition.

[0019] When the extract is subjected to an enzymatic hydrolysis treatment, as the enzyme, one or two or more selected from any enzyme group of proteases such as actinase, papain, pepsin, amylolytic enzymes such as glucoamylase, α-amylase, β-amylase, cellulolytic enzymes such as cellulase, hemicellulase, pectinase, and lipolytic enzymes such as lipase may be used, but it is more preferable to use a combination of one or two or more enzymes respectively selected from these enzyme groups.

[0020] The added amount of the enzyme is, for example, in the case of the whole plant, or flower parts and / or fruits of apricot, common apricot, Japanese plum, or Japanese apricot, preferably in the total range of 0.01 to 10% by weight, more preferably in the range of 0.1 to 2.0% by weight, relative to the solid content thereof.

[0021] The extract prepared as described above may generally be adjusted to a pH of 4 to 8, and then used as it is as a blending component of the external skin composition, or may be concentrated under reduced pressure or the like to a desired concentration for use. In addition, the extract may be made into a dried product by a conventional method such as a spray drying method.

[0022] Further, the extract prepared as described above may be stored under refrigeration for a certain period of time to enhance storage stability and the like, and then the supernatant may be used as a blending component of the external skin composition.

[0023] In the present invention, in addition to the above extract such as apricot, an asparagus extract may also be used in combination. The asparagus referred to herein is Asparagus officinalis, a plant belonging to the genus Asparagus of the Asparagaceae family, and it is more preferable to use the white one (white asparagus) cultivated without exposure to sunlight. White asparagus is distinguished from green asparagus which is cultivated with exposure to sunlight and contains chlorophyll.

[0024] Examples of the external skin composition (including cosmetics, quasi-drugs, and external pharmaceuticals) containing the extract according to the present invention include external skin compositions such as milky lotions, creams, lotions, essences, and packs; makeup external skin compositions such as lipsticks, foundations, liquid foundations, makeup pressed powders, blushes, and face powders; cleansing compositions such as facial cleansers, body shampoos, hair shampoos, and soaps; hair growth agents, as well as bath agents and the like, but of course not limited thereto. It can also be used for a mask using a sheet impregnated with the composition of the present invention.

[0025] The blending amount of the extract such as apricot and common apricot in the external skin composition of the present invention, calculated as the solid content of the extract, is generally in the range of 0.002 to 1.0% by weight, preferably 0.02 to 0.2% by weight for external skin compositions; generally in the range of 0.002 to 1.0% by weight, preferably 0.02 to 0.2% by weight for makeup compositions; and generally in the range of 0.002 to 10.0% by weight, preferably 0.02 to 7.0% by weight for cleansing compositions.

[0026] In addition to essential components such as apricot and Japanese apricot extracts, the present invention may appropriately incorporate other components commonly used in topical skin compositions, such as oily components, surfactants (synthetic and natural), humectants, thickeners, emulsifiers or emulsifying aids, preservatives and bactericides, powder components, UV absorbers, antioxidants, pigments, fragrances, whitening agents, anti-wrinkle agents, and other physiologically active components, as needed.

[0027] Here, the oily components include, for example, plant-derived oils and fats such as olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, coconut oil, palm oil, cocoa oil, meadowfoam oil, shea butter, tea tree oil, avocado oil, macadamia nut oil, bergamot oil, lavender oil, rose oil, chamomile oil, etc.; vitamin A oil; animal-derived oils and fats such as mink oil and turtle oil; waxes such as beeswax, carnauba wax, rice wax, and lanolin; hydrocarbons such as liquid paraffin, petrolatum, paraffin wax, and squalane; myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, and cis-11-eicosenoic acid. Examples include fatty acids such as lauryl alcohol, cetanol, pantothenyl alcohol, and stearyl alcohol; synthetic esters and synthetic triglycerides such as isopropyl myristate, isopropyl palmitate, butyl oleate, 2-ethylhexylglyceride, glyceryl tri-2-ethylhexanoate, trimethylpropane tri-2-ethylhexanoate, caprylic / capric triglyceride, caprylic / capric / myristic / stearic triglyceride, glyceryl triisostearate, polyglyceryl triisostearate, and higher fatty acid octyldodecyl (octyldodecyl stearate, etc.).

[0028] Examples of surfactants include nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkylphenyl ether sulfates, polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, and polyoxyethylene Anionic surfactants such as ethylene alkylphenyl ether phosphates; cationic surfactants such as quaternary ammonium salts, primary to tertiary fatty amine salts, trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N,N-dialkylmorphonium salts, polyethylene polyamine fatty acid amide salts; and amphoteric surfactants such as N,N-dimethyl-N-alkyl-N-carboxymethylammonium betaine, N,N,N-trialkyl-N-alkyleneammonium carboxybetaine, and N-acylamidopropyl-N′,N′-dimethyl-N′-β-hydroxypropylammonium sulfobetaine can be used.

[0029] As emulsifiers and / or emulsifying aids, stevia derivatives such as enzyme-treated stevia, saponins or their derivatives, casein or its salts (sodium, etc.), sugar-protein complexes, sucrose or its esters, lactose, water-soluble polysaccharides derived from soybeans, complexes of soybean-derived proteins and polysaccharides, lanolin or its derivatives, cholesterol, stevia derivatives (such as enzyme-treated stevia), silicates (aluminum, magnesium, etc.), carbonates (calcium, sodium, etc.), saponins and their derivatives, lecithin and its derivatives (such as hydrogenated lecithin), lactic acid bacteria-fermented rice, lactic acid bacteria-fermented germinated rice, lactic acid bacteria-fermented grains (wheat, beans, grains, etc.), etc. may also be included.

[0030] Examples of humectants include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and sugars such as trehalose and raffinose, mucopolysaccharides (e.g., hyaluronic acid and its derivatives, hyaluronic acid ferment filtrate, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, collagen peptides, NMF-related substances, lactic acid, urea, higher fatty acid octyldodecyl, seaweed extracts, estradiol, various amino acids and their derivatives.

[0031] Examples of thickening agents include components derived from brown algae, green algae, or red algae such as alginic acid, agar, carrageenan, and fucoidan; polysaccharides such as pectin and aloe polysaccharide; gums such as tragacanth gum, locust bean gum, xanthan gum, and guar gum; cellulose derivatives such as carboxymethylcellulose, hydroxyethylcellulose, and hydroxypropylcellulose; synthetic polymers such as carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, and acrylic acid / methacrylic acid copolymer; hyaluronic acid and its derivatives; polyglutamic acid and its derivatives, polyacrylic acid, etc.

[0032] Anti-inflammatory agents include allantoin, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, stearyl glycyrrhetinate, ε-aminocaproic acid, d-camphor, dl-camphor, zinc oxide, panthenol, pyridoxine hydrochloride, and riboflavin or its derivatives.

[0033] Examples of preservatives and disinfectants include urea; benzoic acid or its salts, parahydroxybenzoic acid esters such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, and butyl parahydroxybenzoate; phenoxyethanol, dichlorophene, hexachlorophene, chlorhexidine hydrochloride, benzalkonium chloride, salicylic acid, sodium salicylate, zinc pyrithione, benzalkonium chloride, ethanol, undecylenic acid, phenols, and aluminum bromide. These include chloroisoquinolinium, resorcinol, jamal (imidazodinylurea), isopropylmethylphenol, triclosan, trichlorocarbanide, trichlorohydroxydiphenol ether, hinokitiol, 1,2-pentanediol, propanediol, concentrated benzalkonium chloride solution 50, essential oils such as peppermint oil and eucalyptus oil, tree bark distillates, radish ferment filtrate, plant-derived ethanol such as sugarcane and corn, or 1,3-butylene glycol.

[0034] Examples of cell activators include pantothenyl alcohol, menthol, dl-menthol, and γ-oryzanol.

[0035] Examples of anti-acne agents include sulfur, salicylic acid or its salts, photosensitizer 201, and pyridoxine dicaprylate.

[0036] Examples of powder components include sericite, titanium dioxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, anhydrous silicic acid, mica, nylon powder, polyethylene powder, silk powder, cellulose-based powders, grain powders (rice, wheat, corn, millet, etc.), and legume powders (soybeans, adzuki beans, etc.).

[0037] Examples of UV absorbers include ethyl para-aminobenzoate, ethylhexyl para-dimethylaminobenzoate, amyl salicylate and its derivatives, 2-ethylhexyl para-methoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-tert-butyl-4-methoxybenzoylmethane, 2-(2-hydroxy-5-methylphenyl)benzotriazole, urocanic acid, ethyl urocanate, and aloe extract.

[0038] Examples of antioxidants include carotenoids such as butylhydroxyanisole, butylhydroxytoluene, propyl gallate, and astaxanthin, vitamin E and its derivatives (e.g., tocopherol acetate, tocopherol nicotinate), and vitamin A or its derivatives (e.g., retinol palmitate).

[0039] Furthermore, examples of whitening agents include one or more selected from ellagic acid and its derivatives, resorcinol derivatives, potassium 4-methoxysalicylate, magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), hydroxybenzoic acid and its derivatives, vitamin E and its derivatives, α-hydroxy acids, nicotinic acid derivatives, magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), AMP (adenosine monophosphate, adenosine monophosphate), plant extracts or hydrolysates thereof that have a whitening effect, kojic acid or its derivatives, ascorbic acid or its derivatives, tranexamic acid or its derivatives, and hydroquinone derivatives.

[0040] Examples of resorcinol derivatives include 4-n-butylresorcinol and 4-isoamylresorcinol; examples of hydroxybenzoic acid derivatives include 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid, and 2-hydroxy-5-propionyloxybenzoic acid; and examples of α-hydroxy acids include lactic acid, malic acid, succinic acid, citric acid, and α-hydroxyoctanoic acid. Examples of plant extracts include one or more selected from mulberry bark extract, chamomile extract, hydrolyzed rice bran extract, saxifrage extract, and white mustard extract or their hydrolyzed products.

[0041] Furthermore, examples of kojic acid derivatives include kojic acid esters such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, and kojic acid dibutyrate, as well as kojic acid ethers and kojic acid sugar derivatives such as kojic acid glucoside. Examples of ascorbic acid derivatives include L-ascorbic acid-2-phosphate sodium, L-ascorbic acid-2-phosphate magnesium, L-ascorbic acid-2-sulfate sodium, and L-ascorbic acid-2-sulfate Ascorbic acid ester salts such as stermagnesium, L-ascorbic acid-2-glucoside, L-ascorbic acid-5-glucoside, ascorbyl tocopheryl maleic acid, ascorbyl tocopheryl potassium phosphate, myristyl 3-glyceryl ascorbate, caprylyl 2-glyceryl ascorbate, and other ascorbic acid sugar derivatives, as well as 6-position acylated products of these ascorbic acid sugar derivatives (acyl groups include hexanoyl, octanoyl, and decanoyl groups), and L-ascorbic acid tetraisopalmitate. Lumitic acid ester, L-ascorbic acid tetra fatty acid esters such as L-ascorbic acid tetralaurate ester, 3-O-ethyl ascorbic acid, L-ascorbic acid-2-phosphate-6-O-palmitate sodium, glyceryl ascorbic acid or its acylated derivatives, ascorbic acid glycerin derivatives such as bisglyceryl ascorbic acid, L-ascorbic acid aminopropyl phosphate, hyaluronic acid derivative of L-ascorbic acid, 3-OD lactose-L-ascorbic acid, i Examples of hydroquinone derivatives include sostearyl ascorbyl phosphate, arbutin (hydroquinone-β-D-glucopyranoside), α-arbutin (hydroquinone-α-D-glucopyranoside), and tranexamic acid derivatives, such as tranexamic acid esters (e.g., lauryl tranexamic acid ester, hexadecyl tranexamic acid ester, cetyl tranexamic acid ester or their salts) and amide forms of tranexamic acid (e.g., methyl tranexamic acid amide).

[0042] Furthermore, examples of anti-wrinkle agents include vitamin A or its derivatives, vitamin E or its derivatives (such as tocopherol acetate), vitamin C or its derivatives (such as ascorbic acid glucoside, 3-O-ethyl ascorbic acid, magnesium ascorbic acid phosphate salt, etc.), pantothenyl alcohol, tranexamic acid, and nicotinamide.

[0043] Furthermore, the following natural ingredients derived from plants or microorganisms can also be used in combination: for example, collagen or its hydrolysates, yeast extract or hydrolysates, lactic acid bacteria cultures, grasses, cruciferous plants, camellias, roses, peonyes, citrus plants, amaranthaceae plants, eelgrasses, legumes, daisies, legumes, mallows, gentians, mints, lotus, cucurbits, Araliaceae plants, nightshades, bignoniaceae plants, Actinidiaceae plants, mulberries, irises, bellflowers, olives, Actinidiaceae plants, mulberries, rhamnoides, orchids, and sumac. Examples include extracts or hydrolyzed or fermented products thereof from one or more plants selected from the families of plants, Garcinia, Valenciaceae, Rutaceae, Myrtaceae, Liliaceae, Crassulaceae, Cupressaceae, Convolvulaceae, and Asparagaceae; extracts or hydrolyzed or fermented products thereof from one or more seaweeds selected from the families of Laminariaceae, Mylinaceae, and Ulvaceae; jellyfish (autolyzed products of moon jellyfish, Echizen jellyfish, etc.); hydrolyzed or fermented products of hyaluronic acid; and extracts or hydrolyzed or fermented products thereof from royal jelly.

[0044] As plant-derived components from the grass family, rice leaf hydrolysate, rice extract hydrolysate, rice bran extract hydrolysate, germinated brown rice hydrolysate, rice ferment filtrate, sake lees extract derived from sake, bamboo shoot peel extract of Madake or Moso bamboo, and adlay seed ferment. As plant-derived components from the Brassicaceae family, extracts or hydrolysates or fermentations thereof of the seeds of Hakugai, Ougai, or Kokugai are particularly preferred. As plant-derived components from the Camellia family, green tea (Yabukita, Samidori, Asahi, Gokou, Ujimidori, Kyomidori, Ujihikari, Samidori, Benifuki, etc.) and black tea (Darjeeling, Assam, Ceylon, Earl Grey, Honey Black Tea, etc.) are particularly preferred. As plant-derived components from the Rosaceae family, extracts of Damask rose flowers, peach flowers, leaves, or immature fruits, strawberry flower extract, and cherry blossom or leaf extract are preferred. Furthermore, as ingredients derived from Paeoniaceae plants, extracts of peony root or flower, and peony flower or root are preferred. As ingredients derived from Amaranthaceae plants, glasswort extract is particularly preferred. As ingredients derived from Zosteraceae plants, eelgrass or dwarf eelgrass extract is particularly preferred. As ingredients derived from Fabaceae plants, extracts of white soybeans or black soybeans or their hydrolysates or fermented soy milk liquid, adzuki bean extract, red clover extract, and kudzu root extract are particularly preferred. As ingredients derived from Asteraceae plants, burdock root extract, sunflower sprout extract, starflower extract, arnica extract, or chamomile flower extract are particularly preferred. As ingredients derived from Malvaceae plants, fermented products of hibiscus, rose of Sharon, or hibiscus are preferred. As ingredients derived from Gentianaceae plants, gentian extract is preferred. As ingredients derived from Lamiaceae plants, green perilla extract and purple beautyberry fruit extract are preferred. As for ingredients derived from Nelumbonaceae plants, lotus flower or lotus seed extract or lotus seed ferment is particularly preferred. As for ingredients derived from Cucurbitaceae plants, loofah extract is particularly preferred. As for ingredients derived from Araliaceae plants, ginseng extract or ferment is preferred. As for ingredients derived from Solanaceae plants, eggplant (long eggplant, water eggplant, American eggplant, Kamo eggplant, etc.) extract is an example. As for ingredients derived from Bignoniaceae plants, Pau d'arco bark extract is preferred. As for ingredients derived from Actinidiaceae plants, immature kiwi extract is preferred.Preferred ingredients from the Moraceae family include mulberry bark extract, mulberry fruit extract, and fig fruit or bark extract. Preferred ingredients from the Rhamnaceae family include jujube fruit extract. Preferred ingredients from the Iridaceae family include saffron. Preferred ingredients from the Campanulaceae family include root extract or hydrolysate of Codonopsis lanceolata. Preferred ingredients from the Anacardiaceae family include mango fruit extract. Preferred ingredients from the Garciniaaceae family include mangosteen fruit extract. Preferred ingredients from the Valenciaceae family include cherimoya fruit extract. Preferred ingredients from the Rutaceae family include Satsuma mandarin, bergamot fruit extract, grapefruit or pomelo fruit (including immature fruit), extracts containing flavonoids and their glycosides found in plants such as grapefruit or hassaku, or sansho seed extract. As ingredients derived from lily-family plants, extracts of Hemerocallis middendorffii, Hemerocallis fulva, Casablanca lily, Madonna lily, or Lilium japonicum are preferred. As ingredients derived from crasliaceae plants, extracts or fermented products of Rhodiola rosea are particularly preferred. As ingredients derived from olive-family plants, extracts of jasmine flowers are particularly preferred. As ingredients derived from cypress-family plants, extracts of Juniperus chinensis fruit are particularly preferred. As ingredients derived from myrtaceae plants, extracts of guava leaf are particularly preferred. As ingredients derived from orchids, extracts of Bletilla striata root are particularly preferred. As ingredients derived from morning glory-family plants, extracts or fermented products thereof of sweet potato, or extracts or fermented products thereof of sweet potato shochu lees are preferred. As ingredients derived from lamibariaceae seaweed, extracts of kelp are particularly preferred, as ingredients derived from miltiorrhiza, extracts of Sargassum fuciformis are preferred, and as ingredients derived from Ulvaceae seaweed, extracts of Ulva lactuca are particularly preferred. As for components derived from seaweed of the family *Sargassum*, *Sargassum* extract is particularly preferred.

[0045] Next, the present invention will be described in more detail with reference to manufacturing examples, formulation examples, and test examples, but the present invention is not limited thereto. In the following, all parts refer to parts by weight, and all percentages refer to weight percent.

[0046] Production Example 1. Preparation of apricot fruit extract solution The peel and seeds were removed from the fruit of the apricot tree, and the mixture was ground into a paste using a pulverizer. 210 g of 1,3-butylene glycol was added to 90 g of this fruit paste, and the mixture was extracted at 4°C. 410 g of purified water was then added, and the mixture was filtered to obtain 590 g of a clear, brown apricot fruit extract solution (solids concentration 1.70%).

[0047] Manufacturing Example 2. Preparation of apricot fruit extract solution The seeds were removed from the apricot fruit and ground into a paste using a grinder. 210 g of 1,3-butylene glycol was added to 90 g of this fruit paste, and the mixture was extracted at 4°C. 410 g of purified water was added to this mixture, and the solution was filtered to obtain 583 g of a clear, brown apricot fruit extract solution (solid content concentration 1.66%).

[0048] Production Example 3. Preparation of apricot fruit extract solution The same procedure as in Production Example 1 was followed, except that propylene glycol was used as the solvent instead of 1,3-butylene glycol, to obtain 557 g of a brown, transparent apricot fruit extract solution (solids concentration 1.60%).

[0049] Manufacturing Example 4. Preparation of apricot fruit extract solution The same procedure as in Production Example 1 was followed, except that propylene glycol was used as the solvent instead of 1,3-butylene glycol, to obtain 551 g of a brown, transparent apricot fruit extract solution (solids concentration 1.59%).

[0050] Manufacturing Example 5. White Asparagus Extract 100g of dried stems of white asparagus (Sesamum indicum), a plant belonging to the genus Sesamum in the family Asparagaceae, were added to 750g of purified water and extracted at 70°C for 2 hours. Then, 750g of a mixed solvent of purified water and 1,3-butylene glycol was added and extracted for 72 hours. Insoluble matter was removed by filtration to obtain 1570g of brown white asparagus stem extract (solid content concentration 0.96%).

[0051] Test Example 1. Gene Expression Evaluation Test In this study example 1, the expression rates of genes for proteins involved in skin turnover [caspase 14 (CASP14) and transglutaminase 1 (TGM1)] were evaluated to assess the effect of normalizing skin turnover. Skin turnover refers to the process in which epidermal cells in the basal layer of the epidermis differentiate and move to the upper layers, namely the spinous layer, granular layer, and stratum corneum, while changing their morphology. Caspase 14 and transglutaminase 1 are proteins involved in the morphological change from cells in the granular layer to cells in the stratum corneum. [Test Method] Normal epidermal cells NHEK were seeded in a 24-well plate (3 × 10⁻¹⁰ 4(cells / well). Next, epidermal cells were cultured at 37°C. After 24 hours, two test groups were prepared: test group (1) in which the sample solution (extract solution from production examples 1-4) and calcium chloride (1.8 mM) were added to the culture medium, and test group (2) in which the sample solvent [1,3-butylene glycol aqueous solution (30%, w / w)] and calcium chloride (1.8 mM) were added. Epidermal cells were cultured at the same temperature for 24 hours in each group. In addition, a control group was prepared by adding only the sample solvent to the culture medium cultured at 37°C. Here, the sample solution was added so that the final concentration as a solution in the culture medium was 2.0%. Next, epidermal cells from test groups (1), (2), and the control group were harvested with 500 μL of Trizol reagent (Invitrogen). To the collected epidermal cells, 100 μL of chloroform was added and mixed by stirring. The mixture was then centrifuged at 12,500 rpm at 4°C for 15 minutes, and 200 μL of the aqueous layer was collected. 250 μL of isopropanol was added to the collected aqueous layer and mixed by stirring. The mixture was then centrifuged at 12,500 rpm at 4°C for 10 minutes to obtain a total RNA precipitate. 1 mL of 75% cold ethanol was added to the total RNA and mixed by stirring. The precipitate was collected by centrifugation at 12,500 rpm at 4°C for 10 minutes. The collected total RNA was reverse transcribed using a designated kit (PrimeScript RT reagent Kit with gDNA Eraser (Perfect Real Time) (Takara Bio Inc.)) to synthesize cDNA. Using synthesized cDNA as a sample, the expression of target genes (caspase 14 (CASP14) gene and transglutaminase 1 (TGM1) gene) and the expression of the internal standard GAPDH gene were detected using the Thermal Cycler Dice Real Time System Single (Takara Bio Inc.) and SYBR Premix Ex Taq™ II (Perfect Real Time) (Takara Bio Inc.). The test results were expressed as a relative expression level of the target gene to the expression level of the GAPDH gene, and further expressed as a relative percentage with the control value set to 100.

[0052] The results of Test Example 1 are shown in Tables 1 and 2. [Table 1] JPEG0007943619000001.jpg63127

[0053] [Table 2] JPEG0007943619000002.jpg62125

[0054] As shown in Table 1, the extract according to the present invention was confirmed to promote the expression of the caspase 14 (CASP14) gene and the transglutaminase 1 (TGM1) gene. This suggests that it exerts an effect of maintaining the normalization of skin cell turnover. Furthermore, it is suggested that normalizing skin cell turnover also normalizes the skin's barrier function.

[0055] Test Example 2. Monitor Test (User Experience) [Sample preparation] First, sample 1 of the present invention was prepared, which contained a mixed solution of the extracts from Production Example 1 and Production Example 5, and comparative sample 1 was prepared, which did not contain the extracts from Production Example 1 or Production Example 5. Note that % represents the weight percentage in the sample solution. 1. Sample 1 of the present invention (1) Extract from Production Example 1 (1.0%) (2) Extract from Production Example 5 (1.0%) (3) 1,3-Butylene glycol (5.0%) (4) Purified water (93.0%) 2. Comparative Sample 1 (1) 1,3-Butylene glycol (5.0%) (2) Purified water (95.0%) [Test Method] Seven men and women aged 25-60 were randomly selected as subjects. One subject was assigned to a test group where Sample 1 of the present invention was applied to the forearm of each subject, and the other to a comparison group where Comparison Sample 1 was applied. Each subject applied the sample twice a day (morning and evening) for 14 days, and then self-evaluated the feel of use (a), moisture level (b), and skin texture (c) on a 5-point scale: A: very good, B: good, C: average, D: somewhat bad, E: bad.

[0056] The results of Test Example 2 are shown in Table 3. The numbers in Table 3 indicate the number of respondents. [Table 3] JPEG0007943619000003.jpg71113

[0057] As shown in Table 3, it was confirmed that the apricot plant extract according to the present invention, when used in combination with white asparagus extract, exhibits remarkably superior effects in terms of usability, moisturizing effect, and improvement of skin texture.

[0058] Test Example 3. Evaluation Test for Promoting Caspase-14 Production Normal epidermal cells NHEK were seeded in a 96-well plate (8 × 10 3 (cells / mL). Next, epidermal cells were cultured at 37°C. After 24 hours, two test groups were prepared: Group (1) to which the present invention samples (extracts from Production Example 1 and Production Example 5) and calcium chloride (1.8 mM) were added to the culture medium, and Group (2) to which the sample solvent (1,3-butylene glycol aqueous solution (30%, w / w)) and calcium chloride (1.8 mM) were added. Epidermal cells were cultured at the same temperature for 48 hours in each group. The concentrations of the prepared samples were adjusted so that the concentrations of the extracts from Production Example 1 and Production Example 5 in the culture medium were 0.5%. In addition, a control group was prepared by adding only the sample solvent to the culture medium cultured at 37°C. Here, the sample solvent was added so that the final concentration in the culture medium was 1.0%. After the culture was completed, the culture medium was removed, fixed with 15% neutral buffered formalin, and then membrane permeabilization treatment with Triton-X followed by blocking. Subsequently, intracellular caspase 14 was stained using anti-caspase 14 as the primary antibody and a secondary antibody labeled with Alexa488. Finally, DNA was stained with Hoechst33342 and quantified using a fluorescence plate reader. The production rate of caspase 14 in the samples of the present invention was calculated using the fluorescence intensity of test group (1) with the fluorescence intensity of test group (2) set to 100, and is shown in Table 4.

[0059] The results of Test Example 3 are shown in Table 4. [Table 4] JPEG0007943619000004.jpg46124

[0060] As shown in Table 4, the combination of the extracts from Production Example 1 and Production Example 5, which are samples of the present invention, was confirmed to promote the production of caspase 14. This suggests that combining the extracts from Production Example 1 and Production Example 5, which are samples of the present invention, improves the effect of normalizing skin cell turnover.

[0061] Test Example 4. Evaluation Test for Promoting Occludin Production In Test Example 4, we evaluate the promotion of production of occludins, proteins that constitute intercellular adhesion factors (tight junctions) responsible for skin barrier function. Normal epidermal cells NHEK were seeded in a 96-well plate (8 × 10 3 (cells / mL). Next, epidermal cells were cultured at 37°C. After 24 hours, test groups were prepared by adding the samples (extracts from Production Example 1 and Production Example 5) to the culture medium, and epidermal cells were cultured at the same temperature for 72 hours in each group. Here, the concentrations of the samples were adjusted so that the final concentration of the solution in the culture medium was 1.0% for the extracts from Production Example 1 and Production Example 5 in the ratios shown in Table 5. In addition, a control group was prepared by adding only the sample solvent (1,3-butylene glycol aqueous solution (30%, w / w)) to the culture medium cultured at 37°C. Here, the sample solvent was added so that the final concentration of the solution in the culture medium was 1.0%. After the end of culture, the culture medium was removed, fixed with 10% trichloroacetic acid, and then membrane permeabilized with Triton-X before blocking. Subsequently, intracellular occludins were stained using an anti-occludin antibody as the primary antibody and an Alexa 488-labeled secondary antibody. Finally, the DNA was stained with Hoechst33342 and then quantified using a fluorescence plate reader. The occludin production rate of the sample of the present invention was calculated using the fluorescence intensity of test group (1) with the fluorescence intensity of test group (2) set to 100, and is shown in Table 6.

[0062] [Table 5] JPEG0007943619000005.jpg4495

[0063] [Table 6] JPEG0007943619000006.jpg57122

[0064] As shown in Table 6, the combination of the extracts from Production Example 1 and Production Example 5, which are samples of the present invention, was confirmed to promote occludin production. This suggests that combining the extracts from Production Example 1 and Production Example 5, which are samples of the present invention, improves skin barrier function.

[0065] Prescription example 1. Lotion [Ingredients] Part Extract from Production Example 1 2.0 Squalane 0.2 Polyoxyethylene (5.5) cetyl alcohol 5.0 Tocopherol acetate 0.02 Dipotassium glycyrrhizinate 0.5 Monoammonium glycyrrhizinate 0.5 Isopropylmethylphenol 0.1 1,3-Butylene glycol 5.0 Sodium citrate 0.2 Methylparaben 0.1 Purified water, in an amount that makes the total volume 100 parts

[0066] Prescription example 2. Lotion A lotion was obtained in the same manner as in Formulation Example 1, except that 2.0 parts of the extract from Production Example 2 were used instead of the extract from Production Example 1 contained in Formulation Example 1.

[0067] Prescription example 3. Lotion A lotion was obtained in the same manner as in Formulation Example 1, except that 2.0 parts of the extract from Production Example 3 were used instead of the extract from Production Example 1 contained in Formulation Example 1.

[0068] Prescription example 4. Lotion A lotion was obtained in the same manner as in Formulation Example 1, except that 2.0 parts of the extract from Production Example 4 were used instead of the extract from Production Example 1 contained in Formulation Example 1.

[0069] Prescription example 5. Lotion [Ingredients] Part Extract from Production Example 1: 1.0 Extract from manufacturing example 5 1.0 Glyceryl caprylate 3.0 Polyglyceryl-10 laurate 3.0 Cetanol 2.0 Behenyl alcohol 2.0 Methylparaben 0.1 Ascorbic acid 3.0 Glycyrrhizic acid 0.5 β-Glycyrrhetinic acid 0.05 Tocopherol nicotinate 0.1 Resorcinol 0.1 Zinc oxide 2.0 dl-camphor 0.5 Glycerin 2.0 1,3-Butylene glycol 5.0 Potassium hydroxide 0.5 Purified water, in an amount that makes the total volume 100 parts

[0070] Prescription example 6. Lotion A lotion was obtained in the same manner as in Formulation Example 5, except that 1.0 part of the extract from Production Example 2 was used instead of the extract from Production Example 1 included in Formulation Example 5.

[0071] Prescription example 7. Lotion A lotion was obtained in the same manner as in Formulation Example 8, except that 1.0 part of the extract from Production Example 3 was used instead of the extract from Production Example 1 included in Formulation Example 5.

[0072] Prescription example 8. Lotion A lotion was obtained in the same manner as in Formulation Example 5, except that 1.0 part of the extract from Production Example 4 was used instead of the extract from Production Example 1 included in Formulation Example 5.

[0073] Prescription example 9. Lotion [Ingredients] Part Extract from manufacturing example 1: 0.5 Jojoba oil 1.0 Polyoxyethylene (5.5) cetyl alcohol 5.0 Methylparaben 0.1 Ascorbic acid glucoside 2.0 Tranexamic acid 1.0 Niacinamide 5.0 ε-aminocaproic acid 0.1 Sulfur 0.2 Estradiol 0.1 Pyridoxine hydrochloride 0.5 Glycerin 5.0 1,3-Butylene glycol 5.0 Sodium citrate 0.2 Sodium pyrosulfite 0.1 d-camphor 0.1 Purified water, in an amount that makes the total volume 100 parts

[0074] Prescription example 10. Emulsion [Ingredients] Part Extract from Production Example 1 2.0 Squalane 5.0 Cyclopentasiloxane 1.0 Hexaran 3.0 Hexyldecyl isostearate 1.0 Caprylic / Capric Triglyceride 1.0 Polyglyceryl-10 laurate 5.0 Polyglyceryl-10 isostearate 5.0 Ascorbyl dipalmitate 15.0 Hydrogenated soy lecithin 1.5 Magnesium ascorbic acid phosphate salt 3.0 Arbutin 3.0 Potassium hydroxide 0.5 Glycerin 3.0 1,3-Butylene glycol 2.0 Carboxymethylcellulose 0.3 Xanthan gum 0.2 Tremella fuciformis polysaccharide 0.2 Sodium hyaluronate 0.01 Tocopherol acetate 0.3 Tocopherol nicotinate 0.1 Glycyrrhizic acid 0.1 Dipotassium glycyrrhizinate 0.1 Isopropylmethylphenol 0.1 Water-soluble collagen 1.0 Hydrolyzed collagen 1.0 Acetylated hyaluronic acid 0.1 Purified water, in an amount that makes the total volume 100 parts

[0075] Prescription example 11. Emulsion An emulsion was obtained in the same manner as in Formula Example 10, except that 2.0 parts of L-ascorbic acid-2-glucoside were used instead of 2.0 parts of magnesium ascorbic acid phosphate in the ingredients of Formula Example 10.

[0076] Prescription example 12. Emulsion An emulsion was obtained in the same manner as in Formula Example 10, except that 1.0 part of tranexamic acid was used instead of 2.0 parts of magnesium ascorbic acid phosphate and 0.5 parts of potassium hydroxide.

[0077] Prescription example 13. Emulsion An emulsion was obtained in the same manner as in Formulation Example 10, except that 3.0 parts of 3-O-ethyl ascorbic acid were used instead of 2.0 parts of magnesium ascorbic acid phosphate in the ingredients of Formulation Example 10.

[0078] Prescription example 14. Emulsion An emulsion was obtained in the same manner as in Formula Example 10, except that 5.0 parts of niacinamide were used instead of 2.0 parts of magnesium ascorbic acid phosphate in the ingredients of Formula Example 10.

[0079] Prescription example 15. Cream [Ingredients] Part Olive oil 5.0 Squalane 5.0 Jojoba oil 5.0 Jojoba wax 1.0 Behenyl alcohol 1.0 Stearyl alcohol 1.0 Candelilla wax 1.0 Lactic acid fermented rice 2.0 Soy-derived hydrogenated lecithin 0.5 Extract from Production Example 1: 1.0 Extract from manufacturing example 5 1.0 Carboxyvinyl polymer 1.0 Sodium alginate 1.0 Glycerin 4.0 pH adjuster (appropriate amount) Preservative 5.2 Purified water, in an amount that makes the total volume 100 parts

[0080] Prescription example 16. Cream The cream was obtained in the same manner as in Formulation Example 15, except that 1.0 part of the extract from Production Example 2 was used instead of the extract from Production Example 1 included in Formulation Example 15.

[0081] Prescription example 17. Cream The cream was obtained in the same manner as in Formulation Example 15, except that 1.0 part of the extract from Production Example 3 was used instead of the extract from Production Example 1 included in Formulation Example 15.

[0082] Prescription example 18. Cream [Ingredients] Part Extract from Production Example 1 2.0 Olive oil 5.0 Jojoba oil 5.0 Squalane 5.0 Hexyldecyl isostearate 5.0 Lauroyl glutamate di(octyldodecyl / phytosteryl) (Behenir) 5.0 Glyceryl caprylate 1.0 Glyceryl stearate 1.0 Isostearyl glyceryl 3.0 γ-oryzanol 0.1 Behenyl alcohol 2.0 Palmitic acid 2.5 D-Panthenyl alcohol 3.0 Allantoin 0.1 Riboflavin 0.01 Resorcinol 0.1 Benzalkonium chloride 0.05 Urea 3.0 β-Glycyrrhetinic acid 0.1 Stearyl glycyrrhetinate 0.1 Ammonium glycyrrhizinate 0.1 Niacinamide 5.0 Lactic acid fermented rice 2.0 Hydrogenated lecithin 0.5 Hydrogenated lysolecithin 0.5 Hydrolyzed collagen 1.0 Xanthan gum 1.0 Zinc oxide 0.5 dl-camphor 0.3 l-menthol 0.5 Purified water, in an amount that makes the total volume 100 parts

[0083] Prescription example 19. Cream The cream was obtained in the same manner as in Formulation Example 18, except that 2.0 parts of the extract from Production Example 2 were used instead of the extract from Production Example 1 included in Formulation Example 18.

[0084] Prescription example 20. Cream The cream was obtained in the same manner as in Formulation Example 18, except that 2.0 parts of the extract from Production Example 3 were used instead of the extract from Production Example 1 included in Formulation Example 18.

[0085] Prescription example 21. Cream The cream was obtained in the same manner as in Formulation Example 18, except that 2.0 parts of the extract from Production Example 4 were used instead of the extract from Production Example 1 included in Formulation Example 18.

[0086] Example 22. Pack Extract from Production Example 1: 1.0 Extract from manufacturing example 5 1.0 Dipropylene glycol 5.0 Polyoxyethylene (60) hydrogenated castor oil 5.0 Cetanol 3.0 Behenyl alcohol 3.0 Allantoin 0.1 Dipotassium glycyrrhizinate 0.1 Ammonium glycyrrhizinate 0.1 β-Glycyrrhetinic acid 0.1 Stearyl glycyrrhetinate 0.1 Salicylic acid 0.1 Tocopherol acetate 0.5 Tocopherol nicotinate 0.1 D-Pantothenyl alcohol 0.3 Resorcinol 0.1 Sulfur 2.0 Estradiol 0.002 Water-soluble collagen 1.0 Xanthan gum 2.0 Polyglyceryl-6 myristate 1.0 Potassium cocoyl glutamate 1.0 Hydrogenated lecithin 3.0 Hydroxylated lecithin 3.0 Purified water, in an amount that makes the total volume 100 parts

[0087] Prescription Example 23: Hair Shampoo [Ingredients] Part Extract from Production Example 1 2.0 Extract from manufacturing example 5 2.0 Sodium laureth sulfate 10.0 Glyceryl monostearate 1.0 Coconut oil fatty acid diethanolamide 2.0 Polyoxyethylene (40) hydrogenated castor oil 0.5 Benzalkonium chloride 1.0 Stearyl alcohol 2.0 Behenyl alcohol 2.0 Dimethicone 3.0 Allantoin 0.1 Dipotassium glycyrrhizinate 0.1 Salicylic acid 0.1 Sodium salicylate 0.1 Tocopherol acetate 0.1 Pyrithione Zinc 0.3 Benzoic acid 0.2 Triclosan 0.2 Citric acid 0.1 Propylene glycol 2.0 Purified water, in an amount that makes the total volume 100 parts

[0088] Prescription Example 24: Hair Conditioner [Ingredients] Part Extract from Production Example 1: 1.0 Extract from manufacturing example 5 1.0 Polyoxyethylene (10) hydrogenated castor oil 1.0 Distearyldimethylammonium chloride 1.5 Stearyltrimethylammonium chloride 2.0 Glyceryl 2-ethylhexanoate 1.0 Benzalkonium chloride 1.0 Cetanol 3.0 Stearyl alcohol 1.0 Allantoin 0.1 Isopropylmethylphenol 0.1 Dipotassium glycyrrhizinate 0.1 Salicylic acid 0.1 Sulfur 0.5 Alkylisoquinolinium bromide solution (75%) 0.06 Pyrithione Zinc 0.3 Methylparaben 0.1 Triclosan 0.2 Resorcinol 0.1 Purified water, in an amount that makes the total volume 100 parts

[0089] Prescription Example 25. Cleansing Cosmetics [Ingredients] Part Extract from Production Example 1 2.0 Potassium cocoyl glycine 5.0 Glycerin 10.0 Glyceryl caprylate 1.0 Sodium lauroyl aspartate 10.0 Water-soluble collagen 5.0 Cetanol 3.0 Myristyl alcohol 3.0 Isopropylmethyl alcohol 0.1 Allantoin 0.1 Sulfur 0.5 Glycyrrhizic acid 0.1 Dipotassium glycyrrhizinate 0.1 Monoammonium glycyrrhizinate 0.1 β-Glycyrrhetinic acid 0.05 Stearyl glycyrrhetinate 0.1 Salicylic acid 0.2 Tocopherol acetate 0.2 Triclosan 0.1 Trichlorocarbanide 0.5 Trichlorohydroxydiphenyl ether 0.2 Concentrated benzalkonium chloride solution 50 0.2 Benzalkonium chloride 0.1 Purified water, in an amount that makes the total volume 100 parts

[0090] Prescription example 26. Sheet mask A sheet mask is obtained by impregnating a nonwoven fabric with the following ingredients. [Ingredients] Part Extract from Production Example 1: 1.0 Extract from manufacturing example 5 1.0 Glycerin 3.0 1,3-Butylene glycol 2.0 L-ascorbic acid 2-glucoside 2.0 Methylparaben 0.2 Citric acid 0.1 Sodium citrate 0.3 Xanthan gum 1.0 Water-soluble collagen 1.0 Sodium hyaluronate 1.0 Potassium hydroxide (appropriate amount) Purified water, in an amount that makes the total volume 100 parts

[0091] Prescription Example 27: Serum [Ingredients] Part Extract from Production Example 1 2.0 Sodium hyaluronate 1.0 Water-soluble collagen 1.0 Tranexamic acid 0.1 Ethanol 2.0 Glycerin 5.0 1,3-Butylene glycol 5.0 Methylparaben 0.1 Citric acid 0.3 Sodium citrate 0.6 Katamenkirinsai extract 5.0 Purified water, in an amount that makes the total volume 100 parts

Claims

1. A composition for promoting stratum corneum formation, containing as an active ingredient an extract of purified water, a polyhydric alcohol, or a mixed solvent of purified water and a polyhydric alcohol from the fruit of apricot (Prunus armeniaca Linne var. ansu Maximowicz) or Japanese apricot (Prunus armeniaca Linne), which belong to the genus Prunus in the Rosaceae family.

2. A composition for promoting stratum corneum formation, containing as active ingredients an extract of purified water, polyhydric alcohol, or a mixed solvent of purified water and polyhydric alcohol from the fruit of apricot (Prunus armeniaca Linne var ansu Maximowicz) or Japanese apricot (Prunus armeniaca Linne), both belonging to the genus Prunus in the Rosaceae family, and an extract of purified water, polyhydric alcohol, or a mixed solvent of purified water and polyhydric alcohol from white asparagus (Asparagus officinalis), a plant belonging to the genus Asparagaceae family.

3. A tight junction formation promoting composition containing, as active ingredients, an extract of purified water, polyhydric alcohol, or a mixed solvent of purified water and polyhydric alcohol from the fruit of apricot (Prunus armeniaca Linne var ansu Maximowicz) or Japanese apricot (Prunus armeniaca Linne), both belonging to the genus Prunus in the Rosaceae family, and an extract of purified water, polyhydric alcohol, or a mixed solvent of purified water and polyhydric alcohol from white asparagus (Asparagus officinalis), a plant belonging to the genus Asparagaceae family.

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