Collagen yarn, method for producing same, and biomaterial

JPWO2025058013A5Pending Publication Date: 2026-06-15
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Filing Date
2026-03-11
Publication Date
2026-06-15

AI Technical Summary

Technical Problem

The prior art is difficult to effectively produce artificial collagen fibers with high affinity, suitable volume and sufficient length for imitating in vivo collagen fibers, especially in the preparation of artificial tendons and membrane materials.

Method used

Collagen fibers with a diameter of between 10 μm and 50 μm and a length of more than twice the diameter were prepared by high shear treatment in a small diameter runner using neutral collagen solution and injecting it into a solidification bath with high concentration of ethanol, and collagen fibers with a diameter of between 10 μm and 50 μm and a length of more than twice the diameter were prepared, and the inherent high directionality of the fibers was ensured by high shear rate and appropriate flow conditions.

Benefits of technology

The high directionality and sufficient length of collagen fibers are achieved, and can effectively imitate collagen fibers in vivo. They are suitable for the preparation of artificial tendons and membrane materials, with good biocompatibility and low antigenicity.

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Abstract

This collagen yarn contains collagen nanofibrils, and has a diameter of 10-50 μm and a total length of 2 × 105 times or more greater than the diameter, wherein the collagen nanofibrils exhibit high alignment properties along the longitudinal direction of the collagen yarn, the high alignment properties are indicated by a fact that the refractive index difference determined by a birefringence measurement performed on a hydrated collagen yarn is 4.3 × 10-4 or more, and the hydrated collagen yarn is obtained by immersing the collagen yarn in a neutral phosphate buffer solution.
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