cosmetic

Abstract

This cosmetic contains (a) a cyclic carboxamide derivative represented by general formula (1) or a pharmacologically acceptable salt thereof, (b) a nonionic surfactant having an HLB of 2-5, and (c) a nonionic surfactant having an HLB of 9-18. (In general formula (1), R1 represents a C1-6 hydrocarbon group that may be substituted with a hydroxyl group, or a hydrogen atom; X represents -CH2- or -N(R2)-; R2 represents a C1-6 hydrocarbon group that may be substituted with a hydroxyl group, or a hydrogen atom; and n is an integer of 1-3.)

Description

Cosmetics

[0001] The present invention relates to a cosmetic preparation.

[0002] A base that combines a nonionic surfactant with a high HLB (HLB 9-18) with a nonionic surfactant with a low HLB (HLB 2-5) provides high hardness while spreading well on the skin upon application and providing a characteristic feel of quick settling, with no slippery feeling or resistance after application. It also has the advantageous properties of spreading lightly on the skin, being non-sticky, refreshing, having excellent penetration, and excellent stability over time. However, with such a base, the settling can be perceived as squeaky, and the lack of stickiness can result in a weak feeling of effectiveness after application, leaving room for improvement.

[0003] For example, there is a demand for cosmetics that spread easily on the skin, are not sticky, have an excellent refreshing feel, have a texture that feels as if the cosmetics stick to the skin when applied (fit feeling), and have an excellent feeling that the active ingredients penetrate the skin (penetration feeling). In response to this demand, an oil-in-water emulsion skin cosmetic has been reported that contains (A) a nonionic surfactant having an HLB of 9 to 18, (B) a nonionic surfactant having an HLB of 2 to 5, (C) a homopolymer or copolymer of 2-acrylamido-2-methylpropanesulfonic acid, and (D) an ester oil having an IOB value of 0.2 to 0.6 (see, for example, Patent Document 1).

[0004] Japanese Patent Application Laid-Open No. 2005-320263

[0005] An object of one embodiment of the present invention is to provide a cosmetic that reduces the squeaky feeling after application, improves smoothness after application, and has an excellent feel when used.

[0006] Hereinafter, embodiments of the present invention will be described in detail. Note that the embodiments are not limited by the following description and can be modified as appropriate within the scope of the present invention. Furthermore, in this specification, unless otherwise specified, the term "to" indicating a range of values ​​means that the values ​​before and after it are included as the lower and upper limits.

[0007] One embodiment of the cosmetic preparation of the present invention as a means for solving the above-mentioned problems contains (a) a cyclic carboxamide derivative represented by the following general formula (1) or a pharmacologically acceptable salt thereof, (b) a nonionic surfactant having an HLB of 2 to 5, and (c) a nonionic surfactant having an HLB of 9 to 18.

[0008] (In the general formula (1), R １ represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, and X represents -CH ２ -, or -N(R ２ )-, R ２ represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, and n is an integer of 1 to 3.

[0009] According to one embodiment of the present invention, it is possible to provide a cosmetic that has a reduced squeaky feeling after application, an improved smoothness after application, and an excellent feel when used.

[0010] (Cosmetic Preparation) The cosmetic preparation of the present embodiment contains (a) a cyclic carboxamide derivative represented by the following general formula (1) or a pharmacologically acceptable salt thereof, (b) a nonionic surfactant having an HLB of 2 to 5, and (c) a nonionic surfactant having an HLB of 9 to 18, and preferably further contains (d) a higher alcohol, and may further contain other ingredients as necessary.

[0011] (In the general formula (1), R １ represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, and X represents -CH ２ -, or -N(R ２ )-, R ２ represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, and n is an integer of 1 to 3.

[0012] <(a) Cyclic carboxamide derivative represented by general formula (1) or pharmacologically acceptable salt thereof> The cyclic carboxamide derivative or pharmacologically acceptable salt thereof (hereinafter, sometimes referred to as "component (a)") is a cyclic carboxamide derivative represented by general formula (1) above or a pharmacologically acceptable salt thereof. Component (a) may be used alone or in combination of two or more. According to the cosmetic preparation of this embodiment, by incorporating component (a), it is possible to reduce the squeaky feeling after application and improve smoothness after application.

[0013] In general formula (1), R １ represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom. １ In the above, the "hydrocarbon group having 1 to 6 carbon atoms" may be a linear, branched, or cyclic saturated hydrocarbon group having 1 to 6 carbon atoms, and examples thereof include alkyl groups, cycloalkyl groups, alkenyl groups, alkynyl groups, cycloalkylalkyl groups, haloalkyl groups, alkoxyalkyl groups, and alkoxycarbonylalkyl groups. Among these, alkyl groups are preferred.

[0014] Furthermore, the phrase "optionally substituted with a hydroxyl group" means that the group may be unsubstituted (i.e., a hydrocarbon group having 1 to 6 carbon atoms), may be substituted with one hydroxyl group, or may be substituted with two or more hydroxyl groups, and among these, substitution with one hydroxyl group is preferred. １ is preferably a hydroxyalkyl group having 1 to 3 carbon atoms.

[0015] In the general formula (1), X is —CH ２ -, or -N(R ２ )-, R ２ represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom. ２ In the above, the "hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group" includes R １ In one embodiment, X is —CH ２n is an integer of 1 to 3, preferably 1.

[0016] In a preferred embodiment of the component (a), in general formula (1), R １ represents a hydroxyalkyl group having 1 to 3 carbon atoms, and X represents -CH ２ It represents - or -NH-, and n is preferably 1.

[0017] A specific example of a suitable cyclic carboxamide derivative is 1-(2-hydroxyethyl)-2-imidazolidinone (in general formula (1), R １ :-CH ２ CH ２ OH, X: —NH—, n: 1); 1-(2-hydroxyethyl)-2-pyrrolidone (in general formula (1), R １ :-CH ２ CH ２ OH, X: -CH ２ -, n:1). Among these, 1-(2-hydroxyethyl)-2-imidazolidinone is preferred.

[0018]

[0019] Component (a) may be a salt of the cyclic carboxamide derivative represented by general formula (1). The type of salt is not particularly limited as long as it is pharmacologically acceptable, and may be an inorganic salt or an organic salt. Examples of inorganic salts include hydrochloride, sulfate, phosphate, hydrobromide, sodium salt, potassium salt, magnesium salt, calcium salt, magnesium salt, and ammonium salt. Examples of organic salts include acetate, lactate, maleate, fumarate, tartrate, methanesulfonate, p-toluenesulfonate, triethanolamine salt, and amino acid salt.

[0020] The content of component (a) is preferably 0.05% by mass or more and 5.0% by mass or less, and more preferably 0.5% by mass or more and 4.0% by mass or less, relative to the total mass of the cosmetic. When the content of component (a) is 0.05% by mass or more and 5.0% by mass or less, the squeaky feeling after application is reduced and the smoothness after application is improved.

[0021] <(b) Nonionic Surfactant with HLB of 9 to 18> The nonionic surfactant with HLB of 9 to 18 (hereinafter, may be referred to as "component (b)") is a nonionic surfactant having an HLB value (hydrophile-lipophile balance value) of 9 or more and 18 or less.

[0022] The component (b) is not particularly limited and can be appropriately selected depending on the purpose. Examples include polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbit fatty acid esters, polyoxyethylene lanolin / lanolin alcohol / beeswax derivatives, polyoxyethylene castor oil / hardened castor oils, polyoxyethylene sterol / hydrogenated sterols, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, polyethylene glycol fatty acid esters, and polyoxyethylene glyceryl isostearate.

[0023] The component (b) may be used alone or in combination of two or more. In particular, from the viewpoint of stability, when a nonionic surfactant having an HLB of 9.0 to 10.0 is used, it is preferably used in combination with a nonionic surfactant having an HLB of 15.0 or more.

[0024] Examples of polyglycerin fatty acid esters include hexaglyceryl monolaurate (HLB 14.5), hexaglyceryl monomyristate (HLB 11.0), hexaglyceryl monostearate (HLB 9.0), hexaglyceryl monooleate (HLB 9.0), decaglyceryl monolaurate (HLB 15.5), decaglyceryl monomyristate (HLB 14.0), decaglyceryl monostearate (HLB 12.0), decaglyceryl monoisostearate (HLB 12.0), decaglyceryl monooleate (HLB 12.0), decaglyceryl distearate (HLB 9.5), and decaglyceryl diisostearate (HLB 10.0). Here, the numbers in parentheses indicate the HLB value.

[0025] Examples of polyoxyethylene glycerin fatty acid esters include polyoxyethylene (hereinafter abbreviated as POE) (5) glyceryl monostearate (HLB 9.5), POE (15) glyceryl monostearate (HLB 13.5), POE (5) glyceryl monooleate (HLB 9.5), and POE (15) glyceryl monooleate (HLB 14.5).

[0026] Examples of polyoxyethylene sorbitan fatty acid esters include mono-coconut oil fatty acid POE (20) sorbitan (HLB 16.9), monopalmitic acid POE (20) sorbitan (HLB 15.6), monostearate POE (20) sorbitan (HLB 14.9), monostearate POE (6) sorbitan (HLB 9.5), tristearate POE (20) sorbitan (HLB 10.5), monoisostearate POE (20) sorbitan (HLB 15.0), monooleic acid POE (20) sorbitan (HLB 15.0), monooleic acid POE (6) sorbitan (HLB 10.0), trioleic acid POE (20) sorbitan (HLB 11.0), and the like.

[0027] Examples of polyoxyethylene sorbitol fatty acid esters include POE(6) sorbitol monolaurate (HLB 15.5), POE(60) sorbitol tetrastearate (HLB 13.0), POE(30) sorbitol tetraoleate (HLB 11.5), POE(40) sorbitol tetraoleate (HLB 12.5), and POE(60) sorbitol tetraoleate (HLB 14.0).

[0028] Examples of polyoxyethylene lanolin, lanolin alcohol, and beeswax derivatives include POE (10) lanolin (HLB 12.0), POE (20) lanolin (HLB 13.0), POE (30) lanolin (HLB 15.0), POE (5) lanolin alcohol (HLB 12.5), POE (10) lanolin alcohol (HLB 15.5), POE (20) lanolin alcohol (HLB 16.0), POE (40) lanolin alcohol (HLB 17.0), and POE (20) sorbitol beeswax (HLB 9.5).

[0029] Examples of polyoxyethylene castor oils and hydrogenated castor oils include POE (20) castor oil (HLB 10.5), POE (40) castor oil (HLB 12.5), POE (50) castor oil (HLB 14.0), POE (60) castor oil (HLB 14.0), POE (20) hydrogenated castor oil (HLB 10.5), POE (30) hydrogenated castor oil (HLB 11.0), POE (40) hydrogenated castor oil (HLB 13.5), POE (60) hydrogenated castor oil (HLB 14.0), POE (80) hydrogenated castor oil (HLB 16.5), and POE (40) hydrogenated castor oil (100) hydrogenated castor oil (HLB 16.5).

[0030] Examples of polyoxyethylene sterols and hydrogenated sterols include POE(5) phytosterol (HLB 9.5), POE(10) phytosterol (HLB 12.5), POE(20) phytosterol (HLB 15.5), POE(30) phytosterol (HLB 18.0), POE(25) phytostanol (HLB 14.5), and POE(30) cholestanol (HLB 17.0).

[0031] Examples of polyoxyethylene alkyl ethers include polyoxyethylene lauryl ethers such as POE (2) lauryl ether (HLB 9.5), POE (4.2) lauryl ether (HLB 11.5), and POE (9) lauryl ether (HLB 14.5); polyoxyethylene cetyl ethers such as POE (5.5) cetyl ether (HLB 10.5), POE (7) cetyl ether (HLB 11.5), POE (10) cetyl ether (HLB 13.5), POE (15) cetyl ether (HLB 15.5), POE (20) cetyl ether (HLB 17.0), and POE (23) cetyl ether (HLB 18.0); Polyoxyethylene stearyl ethers such as POE (4) stearyl ether (HLB 9.0) and POE (20) stearyl ether (HLB 18.0); Polyoxyethylene oleyl ethers such as POE (7) oleyl ether (HLB 10.5), POE (10) oleyl ether (HLB 14.5), POE (15) oleyl ether (HLB 16.0), POE (20) oleyl ether (HLB 17.0), and POE (50) oleyl ether (HLB 18.0); Polyoxyethylene behenyl ethers such as POE (10) behenyl ether (HLB 10.0), POE (20) behenyl ether (HLB 16.5), and POE (30) behenyl ether (HLB 18.0); POE (2) (C12-15) alkyl ether (HLB 9.0), POE (4) (C12-15) alkyl ether (HLB 10.5), POE (10) (C12-15) alkyl ether (HLB 15.5), POE (5) secondary alkyl ether (HLB 10.5), POE (7) secondary alkyl ether (HLB 12.0), POE (9) alkyl ether (HLB 13.5), POE (12) alkyl ether (HLB 14.5); and the like.

[0032] Examples of polyoxyethylene polyoxypropylene alkyl ethers include polyoxyethylene (hereinafter abbreviated as POE) (1) polyoxypropylene (hereinafter abbreviated as POP) (4) cetyl ether (HLB 9.5), POE (10) POP (4) cetyl ether (HLB 10.5), POE (20) POP (8) cetyl ether (HLB 12.5), POE (20) POP (6) decyl tetradecyl ether (HLB 11.0), and POE (30) POP (6) decyl tetradecyl ether (HLB 12.0).

[0033] Examples of polyethylene glycol fatty acid esters include polyethylene glycol monolaurate (hereinafter abbreviated as PEG) (10) (HLB 12.5), PEG monostearate (10) (HLB 11.0), PEG monostearate (25) (HLB 15.0), PEG monostearate (40) (HLB 17.5), PEG monostearate (45) (HLB 18.0), PEG monostearate (55) (HLB 18.0), PEG monooleate (10) (HLB 11.0), PEG distearate (HLB 16.5), and PEG diisostearate (HLB 9.5).

[0034] Examples of polyoxyethylene glyceryl isostearate include PEG (8) glyceryl isostearate (HLB 10.0), PEG (10) glyceryl isostearate (HLB 10.0), PEG (15) glyceryl isostearate (HLB 12.0), PEG (20) glyceryl isostearate (HLB 13.0), PEG (25) glyceryl isostearate (HLB 14.0), PEG glyceryl (30) isostearate (HLB 15.0), PEG (40) glyceryl isostearate (HLB 15.0), PEG (50) glyceryl isostearate (HLB 16.0), and PEG (60) glyceryl isostearate (HLB 16.0).

[0035] As one embodiment of component (b), it is preferable to include a combination of polyethylene glycol (40) monostearate (HLB 17.5) and polyoxyethylene (20) sorbitan monostearate (HLB 14.9, also known as polysorbate 60), since this increases the interfacial film hardness and thereby provides high stability.

[0036] The content of component (b) is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.5% by mass to 5.0% by mass, and more preferably 0.5% by mass to 2.0% by mass, relative to the total mass of the cosmetic. If the content of component (b) is less than 0.5% by mass, the system may become unstable, and if it exceeds 5.0% by mass, the effect is not enhanced and stickiness may occur.

[0037] <(c) Nonionic Surfactant with HLB of 2 to 5> The nonionic surfactant with HLB of 2 to 5 (hereinafter, sometimes referred to as "component (c)") is a nonionic surfactant having an HLB value of 2 or more and 5 or less.

[0038] The component (c) is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include POE (2) stearyl ether (HLB 4.0), self-emulsifying propylene glycol monostearate (HLB 4.0), glyceryl myristate (HLB 3.5), glyceryl monostearate (HLB 4.0), self-emulsifying glyceryl monostearate (HLB 4.0 to 5.0), glyceryl monoisostearate (HLB 4.0), glyceryl monooleate (HLB 2.5), hexaglyceryl tristearate (HLB 2.5), decaglyceryl pentastearate (HLB 3.5), and deca pentaisostearate. Glyceryl (HLB 3.5), decaglyceryl pentaoleate (HLB 3.5), sorbitan monostearate (HLB 4.7), sorbitan tristearate (HLB 2.1), sorbitan monoisostearate (HLB 5.0), sorbitan sesquiisostearate (HLB 4.5), sorbitan monooleate (HLB 4.3), POE (6) sorbit hexastearate (HLB 3.0), POE (3) castor oil (HLB 3.0), PEG (2) monostearate (HLB 4.0), ethylene glycol monostearate (HLB 3.5), PEG (2) stearate (HLB 4.5), and the like.

[0039] The component (c) may be used alone or in combination of two or more. Among these, from the viewpoint of contributing to improved stability, it is preferable to include sorbitan tristearate (HLB 2.1), and it is preferable to include a combination of sorbitan tristearate and glyceryl stearate (glyceryl monostearate, self-emulsifying glyceryl monostearate, etc.).

[0040] The content of component (c) is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.1% by mass to 5.0% by mass, and more preferably 0.1% by mass to 2.0% by mass, relative to the total mass of the cosmetic. If the content of component (c) is less than 0.1% by mass, the feeling of penetration may not be achieved, and if it exceeds 5.0% by mass, the stability of the system may be reduced.

[0041] <(d) Higher Alcohol> It is preferable that the cosmetic of the present embodiment further contains (d) higher alcohol (hereinafter, sometimes referred to as “component (d)”), since this forms an α-gel, thereby improving stability and increasing lightness of spreadability.

[0042] The component (d) is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include straight-chain alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol; and branched-chain alcohols such as lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, and octyldodecanol.

[0043] The component (d) may be used alone or in combination of two or more. Among these, in terms of contributing to improved stability, it is preferable to include either behenyl alcohol or stearyl alcohol, and it is preferable to include a combination of behenyl alcohol and stearyl alcohol.

[0044] The content of component (d) is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.1% by mass to 5.0% by mass, and more preferably 0.1% by mass to 2.0% by mass, relative to the total mass of the cosmetic. If the content of component (d) exceeds 5.0% by mass, the stability of the system may deteriorate.

[0045] <Water> The amount of water contained in the cosmetic of the present embodiment is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 50% by mass or more and 95% by mass or less, and more preferably 60% by mass or more and 90% by mass or less, relative to the total amount of the cosmetic.

[0046] <Other Components> In addition to the essential components (a) to (c), the cosmetic of this embodiment may contain optional components that are blended into known cosmetic preparations as other components. There are no particular restrictions on the other components, and known cosmetic preparation components can be appropriately selected depending on the purpose. Examples of such other components include drugs other than component (a), surfactants other than components (b) to (c), thickeners, oils, moisturizers, alcohols having 6 or fewer carbon atoms, buffers, preservatives, chelating agents, stabilizers, UV absorbers, pigments, etc.

[0047] Drugs include drugs other than component (a), such as salt-type drugs, vitamins, plant extracts, anti-inflammatory agents, and whitening agents.

[0048] -Surfactant- Examples of surfactants include anionic surfactants, cationic surfactants, nonionic surfactants other than components (b) to (c), and amphoteric surfactants.

[0049] Examples of anionic surfactants include fatty acid soaps such as sodium laurate and sodium palmitate; higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate; alkyl ether sulfates such as polyoxyethylene triethanolamine lauryl sulfate and sodium polyoxyethylene lauryl sulfate; N-acyl sarcosinates such as sodium lauroyl sarcosinate; higher fatty acid amide sulfonates such as sodium N-myristoyl-N-methyl taurate, sodium N-stearoyl-N-methyl taurate, sodium coconut oil fatty acid methyl tauride, and sodium lauryl methyl tauride; phosphate salts such as sodium polyoxyethylene oleyl ether phosphate and sodium polyoxyethylene stearyl ether phosphate; sodium di-2-ethylhexyl sulfosuccinate and monolauroyl monoethanolamide polyoxyethylene. alkylbenzenesulfonates such as sodium diethylene sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate; N-acylglutamic acids such as monosodium N-lauroyl glutamate and disodium N-stearoyl glutamate; higher fatty acid ester sulfates such as hydrogenated coconut oil fatty acid glycerin sodium sulfate; polyoxyethylene alkyl ether carboxylates, α-olefin sulfonates, higher fatty acid ester sulfonates, secondary alcohol sulfates, higher fatty acid alkylolamide sulfates, sodium lauroyl monoethanolamide succinate, N-palmitoyl aspartic acid, ditriethanolamine, and coconut oil fatty acid collagen hydrolyzed alkali salts.

[0050] Examples of cationic surfactants include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride; dialkyldimethylammonium salts such as distearyldimethylammonium chloride; alkylpyridinium salts such as poly(N,N'-dimethyl-3,5-methylenepiperidinium chloride) and cetylpyridinium chloride; alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, polyoxyethylene alkylamines, alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride, cationic polymers, and β-N-N-dimethyl-N-ethylammonioethyl acrylate vinylpyrrolidone chloride copolymers.

[0051] Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants such as 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium and 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt; and betaine-based amphoteric surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amido betaine, and sulfobetaine.

[0052] -Thickener- Examples of thickeners include plant-based polymers, animal-based polymers, microbial-based polymers, starch-based polymers, cellulose-based polymers, alginic acid-based polymers, vinyl-based polymers, acrylic-based polymers, inorganic water-soluble polymers, etc. These may be used alone or in combination of two or more.

[0053] Examples of plant-derived polymers include gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, gellan gum, carrageenan, pectin, and agar.

[0054] Examples of animal-derived polymers include collagen, casein, albumin, and gelatin.

[0055] Examples of microbial polymers include xanthan gum, dextran, succinoglucan, and pullulan.

[0056] Examples of starch-based polymers include vegetable starches such as those from corn, wheat, potato, and rice; carboxymethyl starch; and methylhydroxypropyl starch.

[0057] Examples of the cellulose polymer include methyl cellulose, nitrocellulose, ethyl cellulose, methylhydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, sodium carboxymethyl cellulose, and crystalline cellulose.

[0058] Examples of alginic acid polymers include sodium alginate and propylene glycol alginate.

[0059] Examples of vinyl polymers include polyvinyl alcohol, polyvinyl acetate, polyvinyl methyl ether, polyvinyl pyrrolidone, copolymers of vinyl pyrrolidone and vinyl acetate, and carboxyvinyl polymers.

[0060] Examples of acrylic polymers include sodium polyacrylate, polyethyl acrylate, alkanolamine polyacrylate, (dimethylacrylamide / sodium acryloyldimethyltaurate) crosspolymer, copolymer of alkyl methacrylate and dimethylaminoethyl methacrylate, poly 2-acrylamido-2-methylpropanesulfonic acid, and polymethacryloyloxytrimethylammonium.

[0061] Examples of inorganic water-soluble polymers include polyethyleneimine, cationic polymers, bentonite, aluminum magnesium silicate, laponite, hectorite, and silicic anhydride.

[0062] -Oil- There are no particular limitations on the oil, and known cosmetic ingredients can be appropriately selected depending on the purpose, and examples include ester oil, hydrocarbon oil, silicone oil, higher fatty acid, alkyl glyceryl ether, liquid oil, solid oil, semi-solid oil, oil-soluble drug, etc. These may be used alone or in combination of two or more.

[0063] Examples of ester oils include octyl octanoate, nonyl nonanoate, cetyl octanoate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, ethylhexyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, 12-hydroxystearyl alcohol, and the like. Cholesteryl phosphate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, tripropylene glycol pivalate, diisostearyl malate, glycerin di-2-heptylundecanoate, glycerin diisostearate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, tetraethylhexane Pentaerythrityl Tri-2-Ethylhexanoate (Triethylhexanoin), Glyceryl Trioctanoate, Glyceryl Triisopalmitate, Trimethylolpropane Triisostearate, Cetyl 2-Ethylhexanoate-2-Ethylhexyl Palmitate, Glyceryl Trimyristate, Tri-2-Heptylundecanoic Acid Glyceride, Castor Oil Fatty Acid Methyl Ester, Oleyl Oleate, Acetoglyceride, 2-Heptylundecyl Palmitate Examples of suitable oils include 2-hexyldecyl palmitate, 2-hexyldecyl palmitate, 2-hexyldecyl adip ...

[0064] Examples of hydrocarbon oils include isododecane, isohexadecane, isoparaffin, mineral oil (liquid paraffin), ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and hydrogenated polydecene.

[0065] Examples of silicone oils include chain polysiloxanes such as dimethicone, diphenylsiloxyphenyl trimethicone, and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane; silicone resins that form a three-dimensional network structure; silicone rubber; various modified polysiloxanes such as amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, and fluorine-modified polysiloxane; and acrylic silicones.

[0066] Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tall acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

[0067] Examples of alkyl glyceryl ethers include batyl alcohol and chimyl alcohol.

[0068] Examples of liquid oils include avocado oil, camellia oil, macadamia nut oil, corn oil, olive oil, rapeseed oil, sesame oil, persic oil, wheat germ oil, camellia oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese tung oil, Japanese tung oil, jojoba oil, germ oil, and triglycerin.

[0069] Examples of solid oils include cacao butter, coconut oil, hardened coconut oil, palm oil, palm kernel oil, hydrogenated palm oil, Japan wax kernel oil, hardened oil, and Japan wax.

[0070] Examples of semi-solid oils include shea butter, partially hydrogenated coconut oil, and partially hydrogenated jojoba oil.

[0071] - Moisturizers - Moisturizers can enhance the moisturizing and hydrating effects of the skin.

[0072] Examples of moisturizing agents include glycerin (dynamite glycerin), 1,3-butylene glycol, propylene glycol, dipropylene glycol, erythritol, maltitol, polyoxyethylene polyoxypropylene alkyl ether, acetylated hyaluronic acid and salts thereof.

[0073] Alcohols Having 6 or Less Carbon Atoms Examples of alcohols having 6 or less carbon atoms include ethanol, propanol, isopropanol, isobutyl alcohol, and t-butyl alcohol.

[0074] -Buffer- Examples of buffers include potassium hydroxide, sodium hydroxide, triethanolamine, sodium carbonate, lactic acid, citric acid, sodium citrate, glycolic acid, succinic acid, tartaric acid, malic acid, sodium hydrogen carbonate, and ammonium hydrogen carbonate.

[0075] - Preservatives - Examples of preservatives include benzoic acid, salicylic acid, paraoxybenzoic acid esters (methylparaben, ethylparaben, butylparaben, etc.), sorbic acid, parachlormetacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizers, and phenoxyethanol.

[0076] —Chelating Agent— Examples of chelating agents include citramalic acid, agaric acid, glyceric acid, shikimic acid, hinokitiol, gallic acid, tannic acid, caffeic acid, ethylenediamine-N,N,N′,N′-tetraacetic acid trisodium salt trihydrate (EDTA-3Na), ethylene glycol diamine tetraacetic acid, diethylenetriamine pentaacetic acid, phytic acid, polyphosphoric acid, metaphosphoric acid, analogs thereof, alkali metal salts thereof, and carboxylic acid esters thereof.

[0077] -Stabilizer- Examples of stabilizers include sodium pyrosulfite, ascorbic acid, α-tocopherol, and carotenoids.

[0078] -Ultraviolet Absorber- Examples of the ultraviolet absorber include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid; anthranilic acid-based ultraviolet absorbers such as methyl anthranilate; salicylic acid-based ultraviolet absorbers such as octyl salicylate; cinnamic acid-based ultraviolet absorbers such as isopropyl paramethoxycinnamate and octyl paramethoxycinnamate; ultraviolet absorbers such as urocanic acid and ethyl urocanate, benzophenone-based ultraviolet absorbers such as 2-hydroxy-4-methoxybenzophenone and dihydroxybenzophenone, benzotriazole-based ultraviolet absorbers, and 2-phenylbenzimidazole-5-sulfonic acid.

[0079] Pigments Examples of pigments include inorganic pigments, organic pigments, pearl pigments, and metal powder pigments.

[0080] [Viscosity] The viscosity of the cosmetic is not particularly limited and can be appropriately selected depending on the purpose. The viscosity at 25°C is preferably 1,000 mPa·s or more, more preferably 2,000 mPa·s or more, and even more preferably 3,000 mPa·s or more.

[0081] The viscosity of the cosmetic can be measured, for example, using a viscosity measuring device (VISCOMETER TVB-15, Toki Sangyo Co., Ltd.) with a No. 3 probe or a No. 4 probe at 30° C. and a rotation speed of 12 rpm.

[0082] [Hardness] The hardness of the cosmetic is not particularly limited and can be appropriately selected depending on the purpose. The hardness at 25°C is preferably 5N or more and 30N or less.

[0083] The hardness of the cosmetic material can be measured using a rheometer (Rheotec Corporation) under the conditions of a pressure-sensitive shaft of 8φ or 11.5φ, 10 mm penetration, a penetration rate of 300 mm / min, and 25°C.

[0084] [Dosage Form] The dosage form of the cosmetic according to one embodiment is not particularly limited and can be selected appropriately depending on the purpose, but is preferably a liquid cosmetic, more preferably a liquid emulsion cosmetic, and even more preferably an oil-in-water emulsion.

[0085] The product form of the cosmetic according to one embodiment is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include cosmetics intended for skin care such as lotion, emulsion, serum, cream, etc.; sunscreen bases; suntan bases; cleansing bases, etc. Among these, the product form of the cosmetic according to one embodiment is preferably used as a cosmetic such as a cream, emulsion, serum, etc., because these have excellent quick absorption during application and reduce stickiness after application.

[0086] [Method for Producing Cosmetics] The method for producing a cosmetic according to one embodiment is not particularly limited, and the cosmetic can be produced according to a method typically used for cosmetics, preferably liquid cosmetic products. A specific example of a method for producing a cosmetic according to one embodiment involves first dissolving component (a) and, if necessary, a water-soluble component appropriately selected from other components in heated water to prepare an aqueous phase. Next, component (b) and component (c), and, if necessary, a water-insoluble component appropriately selected from component (d) and other components, are heated and mixed to prepare an oil phase. Finally, the heated oil phase is gradually added to the heated aqueous phase while stirring to emulsify, and the mixture is then cooled to produce a cosmetic according to one embodiment.

[0087] The present invention will be described in more detail below based on examples, but the present invention is not limited to the following examples. In the description of these examples, percentages (% and parts) indicate "mass %" relative to the total mass of the cosmetic unless otherwise specified, and all values ​​are converted into pure contents.

[0088] Example 1 A cosmetic composition was prepared according to the formulation shown in Table 1 below.

[0089] Specifically, the oil phase was prepared by uniformly mixing and dissolving component (b), component (c), component (d), and oil at 70°C. Meanwhile, the other water-soluble components were uniformly mixed and dissolved at 70°C to prepare an aqueous phase. Next, the oil phase at 70°C was gradually added to the aqueous phase, which was kept at 70°C, while emulsifying the mixture in a homomixer. After emulsification, the mixture was rapidly cooled to 40°C or below, and the desired oil-in-water emulsion, the lotion of Example 1, was prepared.

[0090] Comparative Example 1 A cosmetic of Comparative Example 1 was prepared in the same manner as in Example 1, except that the essential component (a) was omitted as shown in Table 1.

[0091] Example 2 A cosmetic material of Example 2 was prepared in the same manner as in Example 1, except that the formulations shown in Tables 2 and 3 were used.

[0092] The prepared cosmetics were evaluated for "feeling of crumbling during application," "smoothness after application," and "squeakiness after application" as follows. The results are shown in Table 1.

[0093] <Feeling of crumbling during application> A sensory evaluation was performed to determine whether or not the prepared cosmetic composition felt like it was crumbling when applied to the skin, using the following procedure and evaluation criteria as follows. - Sensory evaluation - Three expert panelists were asked to apply the prepared cosmetic composition to the back of their hands at room temperature (25°C ± 5°C), and the feel when used was evaluated with the cosmetic composition of Comparative Example 1 as the standard (STD). Evaluation criteria unanimous by the three expert panelists were used. - Evaluation criteria - 0: No feeling of crumbling felt compared to the STD 1: Feeling of crumbling felt compared to the STD 2: Feeling of crumbling felt even without comparing to the STD

[0094] <Smoothness after application> When the prepared cosmetic preparations were applied to the skin, a sensory evaluation was performed according to the procedure described below to determine whether or not the cosmetic preparations felt smooth after application, and the evaluation was based on the following evaluation criteria. -Evaluation criteria- 0: No feeling of smoothness after application compared to STD 1: Feeling of smoothness after application compared to STD 2: Feeling of smoothness after application even without comparison to STD

[0095] <Squeaky feeling after application> When the prepared cosmetic preparations were applied to the skin, a sensory evaluation was performed according to the procedure described below to determine whether or not a squeaky feeling was felt after application, and the evaluation was based on the following evaluation criteria. -Evaluation criteria- 0: A similar squeaky feeling was felt after application compared to the STD. -1: No squeaky feeling was felt after application compared to the STD. -2: No squeaky feeling was felt after application, even without comparing with the STD.

[0096]

[0097] In Comparative Example 1, which was used as the standard (STD), there was a squeaky feeling after application and the smoothness after application was insufficient. In contrast, as shown in Table 1, the cosmetics of Examples 1 and 2 contained all of the components (a) to (c), and therefore the squeaky feeling after application was reduced, the smoothness after application was improved, and it was found that they had an excellent feel when used.

[0098] The components used in Table 1 are as follows:

[0099]

[0100] The present invention provides, for example, the following embodiments: <1> (a) a cyclic carboxamide derivative represented by the following general formula (1) or a pharmacologically acceptable salt thereof;

[0101] (In the general formula (1), R １ represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, and X represents -CH ２ -, or -N(R ２ )-, R ２ represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, and n is an integer of 1 to 3.) A cosmetic characterized by containing (b) a nonionic surfactant having an HLB of 9 to 18, and (c) a nonionic surfactant having an HLB of 2 to 5. <2> In the general formula (1), R １ represents a hydroxyalkyl group having 1 to 3 carbon atoms, and X represents -CH ２The cosmetic preparation according to <1>, wherein n represents - or -N(H)-, and n is 1. <3> The cosmetic preparation according to <1> or <2>, wherein the component (a) is 1-(2-hydroxyethyl)-2-imidazolidinone. <4> The cosmetic preparation according to any one of <1> to <3>, wherein the component (b) includes a combination of polyethylene glycol (40) monostearate and polyoxyethylene (20) sorbitan monostearate. <5> The cosmetic preparation according to any one of <1> to <4>, wherein the component (c) includes a combination of sorbitan tristearate and glyceryl stearate. <6> The cosmetic preparation according to any one of <1> to <5>, further comprising (d) a higher alcohol. <7> The cosmetic preparation according to any one of <1> to <6>, wherein the content of the component (a) is 0.05% by mass or more and 5.0% by mass or less. <8> The cosmetic preparation according to any one of <1> to <7>, wherein the content of the component (b) is 0.5% by mass or more and 5.0% by mass or less. <9> The cosmetic preparation according to any one of <1> to <8>, wherein the content of the component (c) is 0.1% by mass or more and 5.0% by mass or less.

[0102] Although the present invention has been described above based on specific embodiments and examples, these embodiments and examples are presented only as examples, and the present invention is not limited to the above embodiments and examples. Various changes, modifications, substitutions, deletions, additions, combinations, etc. are possible within the scope of the disclosure of the present invention.

[0103] This application claims priority based on Japanese Patent Application No. 2023-215675, filed December 21, 2023, the entire contents of which are incorporated herein by reference.

Claims

1. (a) a cyclic carboxamide derivative represented by the following general formula (1) or a pharmacologically acceptable salt thereof; (In the general formula (1), R １ represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom; X represents -CH ２ -, or -N(R ２ )-, R ２ represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, and n is an integer from 1 to 3. A cosmetic preparation comprising: (b) a nonionic surfactant having an HLB of 9 to 18; and (c) a nonionic surfactant having an HLB of 2 to 5.

2. In the general formula (1), R １ represents a hydroxyalkyl group having 1 to 3 carbon atoms, and X represents -CH ２ The cosmetic preparation according to claim 1, wherein n is - or -N(H)-, and n is 1.

3. The cosmetic preparation according to claim 1, wherein the component (a) is 1-(2-hydroxyethyl)-2-imidazolidinone.

4. The cosmetic preparation according to claim 1, wherein the component (b) comprises a combination of polyethylene glycol (40) monostearate and polyoxyethylene (20) sorbitan monostearate.

5. The cosmetic preparation according to claim 1, wherein the component (c) comprises a combination of sorbitan tristearate and glyceryl stearate.

6. The cosmetic preparation according to claim 1, further comprising (d) a higher alcohol.

7. The cosmetic preparation according to claim 1, wherein the content of component (a) is 0.05% by mass or more and 5.0% by mass or less.

8. The cosmetic preparation according to claim 1, wherein the content of component (b) is 0.5% by mass or more and 5.0% by mass or less.

9. The cosmetic preparation according to claim 1, wherein the content of component (c) is 0.1% by mass or more and 5.0% by mass or less.