Bed bug control agent and bed bug control method

Abstract

Provided is a bed bug control agent having an excellent controlling effect against resistant bed bugs.　This bed bug control agent for controlling resistant bed bugs comprises a specific pyrethroid compound having a vapor pressure of at least 6.6661×10-3 Pa at 25ºC, wherein the specific pyrethroid compound is profluthrin and / or empenthrin, and said bed bug control agent is for contact control or spatial control.

Description

Bed bug control agent and bed bug control method

[0001] The present invention relates to a bed bug control agent for controlling resistant bed bugs and a bed bug control method.

[0002] In recent years, damage caused by bed bugs has become a problem, and countermeasures are being sought. Bed bugs have habits that are different from other pests: they hide in narrow gaps and cracks in bedding and walls during the day, and leave their habitats at night to wander around to suck blood. Therefore, considering the difficulty of delivering pesticides such as DEET to bed bug habitats, a method has been proposed in which pesticides are applied in a space away from the habitat, preventing bed bugs from spreading to the surrounding area (see Patent Document 1).

[0003] On the other hand, some bed bugs are resistant to insecticidal components such as pyrethroid compounds, etc. Therefore, in order to control resistant bed bugs, it has been proposed to use transfluthrin alone as an insecticidal compound containing a polyfluorobenzyl moiety in combination with another insecticide (an insecticide other than an insecticidal compound containing a polyfluorobenzyl moiety) (see Patent Document 2).

[0004] JP 2015-214507 A JP 2016-503426 A

[0005] In Patent Document 1, bed bugs are controlled by treating the area with the chemical appropriately, but the control effect of the chemical itself is not focused on, and in this respect it is difficult to say that the control effect is high. Furthermore, the control effect against pyrethroid-resistant bed bugs is not focused on, and the control effect is not clarified.

[0006] In Patent Document 2, transfluthrin is used as the pesticide, but it is difficult to say that transfluthrin itself has a high control effect against resistant bed bugs.

[0007] The present invention has been made in view of the above problems, and aims to provide a bed bug control agent and a bed bug control method that are highly effective in controlling resistant bed bugs.

[0008] The present inventors conducted intensive research to solve the above-mentioned problems and found that a pyrethroid compound cannot exhibit a high control effect against resistant bed bugs simply by having a polyfluorobenzyl moiety (structure) in the molecule, as in Patent Document 2. Based on this finding, those skilled in the art conducted intensive research and found that a pyrethroid compound having a specific vapor pressure exhibits a high control effect against resistant bed bugs, which led to the completion of the present invention.

[0009] The bed bug control agent according to the present invention for solving the above problems has a characteristic configuration for controlling resistant bed bugs, and has a vapor pressure of 6.6661×10 at 25° C. －３ The purpose of the present invention is to contain a specific pyrethroid compound having a viscosity of 100 Pa or more.

[0010] According to the bed bug control agent of this configuration, the vapor pressure at 25°C is 6.6661 x 10 －３ By containing the specific pyrethroid compound having a viscosity of 100 Pa or more, the composition has excellent control effect against resistant bed bugs.

[0011] In the bed bug control agent according to the present invention, the specific pyrethroid compound is preferably profluthrin and / or empenthrin.

[0012] According to the bed bug control agent of this configuration, the vapor pressure at 25°C is 6.6661 x 10 －３ When the specific pyrethroid compound having a viscosity of 100 Pa or more is profluthrin and / or empenthrin, the control effect against resistant bed bugs can be further enhanced.

[0013] The bed bug control agent according to the present invention is preferably for contact control or space control.

[0014] According to the bed bug control agent of this configuration, when the bed bug control agent is for contact control, the bed bug control agent is attached to the surface of a floor, wall and / or article where resistant bed bugs may hide or wander, and when the bed bug control agent comes into contact with the resistant bed bugs, the vapor pressure at 25°C is 6.6661 x 10 －３ The specific pyrethroid compound having a viscosity of 100 Pa or more can be allowed to act on resistant bed bugs. When the bed bug control agent is for spatial control, the bed bug control agent is sprayed or vaporized into a space where resistant bed bugs may be present, causing the bed bug control agent to volatilize into the space, and the specific pyrethroid compound can be allowed to act on resistant bed bugs in that atmosphere. In this way, by using the bed bug control agent for contact control or spatial control, the specific pyrethroid compound can be allowed to act more appropriately on resistant bed bugs, thereby further improving the control effect.

[0015] In the bed bug control agent according to the present invention, the amount of the specific pyrethroid compound blended is preferably 1 to 30 w / v %.

[0016] According to the bed bug control agent of the present configuration, the amount of the specific pyrethroid compound blended is within the above range, so that the control effect against resistant bed bugs can be further enhanced.

[0017] In the bed bug control agent according to the present invention, the bed bug control agent is for contact control, and the treatment amount thereof is such that the amount of the specific pyrethroid compound attached to the control target surface is 15 mg / m ２ It is preferable to set it to the above.

[0018] According to the bed bug control agent of this configuration, when the bed bug control agent is for contact control, the contact control effect can be further enhanced by setting the treatment amount so that the amount of the specific pyrethroid compound attached to the control target surface is within the above-mentioned range.

[0019] In the bed bug control agent according to the present invention, the bed bug control agent is for space control, and the treatment amount thereof is such that the amount of the specific pyrethroid compound to be treated with respect to the space to be controlled is 1000 mg / m ３ It is preferable to set it to the above.

[0020] According to the bed bug control agent of this configuration, when the bed bug control agent is for spatial control, the spatial control effect can be further enhanced by setting the treatment amount so that the treatment amount of the specific pyrethroid compound for the space to be controlled is within the above range.

[0021] Another bed bug control method according to the present invention for solving the above-mentioned problems is characterized by the fact that it is a bed bug control method for controlling resistant bed bugs, and includes a contact treatment step of attaching the bed bug control agent to the surface of a floor, wall and / or object where the resistant bed bugs may hide or wander.

[0022] According to the bed bug control method of this configuration, a bed bug control agent is attached to the surface of a floor, wall and / or article where resistant bed bugs may hide or wander, and when the bed bug control agent comes into contact with the resistant bed bugs, the vapor pressure at 25°C is 6.6661 x 10 －３ The specific pyrethroid compound having a viscosity of 100 Pa or more can be allowed to act on resistant bed bugs. By carrying out such a method for controlling bed bugs, it becomes possible to control resistant bed bugs.

[0023] Another bed bug control method according to the present invention for solving the above problem is characterized by the fact that it is a bed bug control method for controlling resistant bed bugs, and includes a space treatment step of spraying, evaporating or vaporizing the bed bug control agent in a space where the resistant bed bugs may be present.

[0024] According to the bed bug control method of this configuration, the bed bug control agent is sprayed, evaporated, or volatilized in a space where resistant bed bugs may be present, and the bed bug control agent is volatilized in the space, and in that atmosphere, the resistant bed bugs are exposed to a vapor pressure of 6.6661 x 10 at 25 ° C.－３ It is possible to use a specific pyrethroid compound having a viscosity of 100 Pa or more. By carrying out such a method for controlling bed bugs, it is possible to control resistant bed bugs.

[0025] In the bed bug control method according to the present invention, it is preferable that the spatial treatment step includes an installation treatment step of installing the bed bug control agent or a drug carrier containing the bed bug control agent on floors, walls and / or objects, or in the vicinity thereof, where the resistant bed bugs may hide or wander.

[0026] According to the bed bug control method of this configuration, in the spatial treatment step, a bed bug control agent or a drug carrier containing the bed bug control agent is placed on floors, walls and / or objects where resistant bed bugs may hide or wander, or in the vicinity thereof, so that the vapor pressure at 25°C of the vaporized bed bug control agent is 6.6661 x 10 －３ This allows the specific pyrethroid compound having a viscosity of 100 Pa or more to act on resistant bed bugs. This allows the resistant bed bugs to be exposed to a higher concentration of the bed bug control agent, thereby achieving a higher control effect on resistant bed bugs.

[0027] Hereinafter, embodiments of the bed bug control agent and bed bug control method of the present invention will be described. However, the present invention is not intended to be limited to the configurations described in the embodiments described below.

[0028] [Bed Bug Control Agent] The bed bug control agent of the present embodiment is a bed bug control agent for controlling resistant bed bugs. In this specification, "control" means repelling, knocking down, or killing resistant bed bugs.

[0029] <Resistant Bed Bugs> The resistant bed bugs that are the target of control by the bed bug control agent of the present invention are bed bugs that are resistant to pyrethroid compounds. Conventionally, pyrethroid compounds such as deltamethrin, fenothrin, and permethrin have been used to control bed bugs, but in recent years, resistant bed bugs that are resistant to these pyrethroid compounds have been discovered. Therefore, in the present invention, such resistant bed bugs are targeted for control. Specifically, resistant bed bugs in this specification are bed bugs that are resistant to pyrethroid compounds (having a vapor pressure of 6.6661 x 10 at 25°C). －３ The term "bed bugs" refers to bed bugs that are resistant to pyrethroid compounds other than the specific pyrethroid compounds (i.e., conventional pyrethroid compounds, particularly permethrin) (i.e., bed bugs that are resistant to conventional pyrethroid compounds, particularly permethrin).

[0030] <Vapor pressure at 25°C is 6.6661 x 10 －３ The bed bug control agent of the present embodiment contains, as an insecticidal component, a pyrethroid compound having a vapor pressure of 6.6661 × 10 Pa or more at 25°C. －３ Pa (5.0 × 10 －５ mmHg) or more (hereinafter referred to as "specific pyrethroid compounds"). The fact that specific pyrethroid compounds have lethal activity even against resistant bed bugs is a new finding that was not previously known. By including the specific pyrethroid compound in the bed bug control agent, it is possible to exert an excellent control effect even against resistant bed bugs that are difficult to control with pyrethroid compounds such as deltamethrin, fenothrin, and permethrin. Examples of specific pyrethroid compounds include profluthrin (1.02658 x 10 －２ Pa (7.7 x 10 －５ mmHg), empenthrine (2.19981 x 10 －２ Pa (16.5 x 10 －５ Here, the unit of vapor pressure is 1 mmHg = 1.33322 × 10 ２The vapor pressure is expressed in units of Pa, with the unit of mmHg written in parentheses after the unit of Pa. The vapor pressure can be measured, for example, by the Donovan method (the method described in "New method for estimating vapor pressure by the use of gas chromatography" in Journal of Chromatography A. Volume 749, Issues 1-2, 1996, Pages 123-129). Profluthrin and empenthrin are highly effective in controlling resistant bed bugs and are preferred specific pyrethroid compounds in the present invention. Note that these specific pyrethroid compounds include optical isomers and geometric isomers based on asymmetric carbons, and these are also included in the specific pyrethroid compounds of the present invention.

[0031] The amount of the specific pyrethroid compound in the bed bug control agent is not particularly limited, but is preferably 0.1 to 100 w / v%, more preferably 0.5 to 80 w / v%, even more preferably 1 to 60 w / v%, and particularly preferably 1 to 30 w / v%.

[0032] <Other Ingredients> (Other Insecticide Ingredients) In addition to the specific pyrethroid compounds, bed bug control agents can contain insecticide ingredients such as other pyrethroid compounds such as transfluthrin, metofluthrin, momfluorothrin, phthalthrin, resmethrin, cyfluthrin, fenothrin, permethrin, cyphenothrin, cypermethrin, allethrin, prallethrin, furamethrin, imiprothrin, bifenthrin, etofenprox, and natural pyrethrins, silicon compounds such as silafluofen, organophosphorus compounds such as dichlorvos and fenitrothion, carbamate compounds such as propoxur, diamide compounds such as brofuranilide, and neonicotinoid compounds such as dinotefuran and imidacloprid. In addition to the specific pyrethroid compounds, bed bug control agents can also contain the above-mentioned other compounds to form comprehensive insecticides (insecticide products).

[0033] When the bed bug control agent contains the other insecticidal component, the blending amount of the total insecticidal components, including the specific pyrethroid compound and the other insecticidal component, is not particularly limited, but is preferably 0.1 to 100 w / v%, more preferably 0.5 to 80 w / v%, and even more preferably 1 to 60 w / v%.

[0034] (Solvent) The bed bug control agent of this embodiment may contain a solvent. Examples of the solvent include water, as well as various organic solvents such as alcohol-based solvents, ketone-based solvents, glycol-based solvents, glycol ether-based solvents, higher fatty acid ester-based solvents, and hydrocarbon-based solvents. As the alcohol-based solvent, lower alcohols having 2 to 3 carbon atoms such as ethanol and isopropanol are preferred, with ethanol being more preferred. As the ketone-based solvent, acetone is preferred. As the glycol-based solvent, hexylene glycol, 1,3-butylene glycol, propylene glycol, dipropylene glycol, etc. can be used, and as the glycol ether-based solvent, diethylene glycol monobutyl ether, propylene glycol monomethyl ether, etc. can be used. As the higher fatty acid ester-based solvent, those having a total carbon number of 13 to 30 are preferred, and those having a total carbon number of 16 to 24 are more preferred. Examples of the higher fatty acid ester-based solvent include isopropyl myristate, butyl myristate, hexyl laurate, and isopropyl palmitate. Examples of the hydrocarbon-based solvent include normal paraffin and isoparaffin.

[0035] (Surfactant) The bed bug control agent of the present embodiment may contain a surfactant as a solubilizer. The surfactant may be any of a cationic surfactant, an anionic surfactant, and a nonionic surfactant.

[0036] (Components Other Than the Above) The resistant bed bug control agent of this embodiment may also be appropriately blended with antifungal agents, antibacterial agents, bactericides, fragrances, deodorizers, stabilizers, antistatic agents, antifoaming agents, excipients, etc. that target molds, fungi, etc. Examples of antifungal agents, antibacterial agents, and bactericides include hinokitiol, 2-mercaptobenzothiazole, 2-(4-thiazolyl)benzimidazole, 5-chloro-2-methyl-4-isothiazolin-3-one, triforine, 3-methyl-4-isopropylphenol, and ortho-phenylphenol. Examples of the fragrances include aromatic components such as orange oil, lemon oil, lavender oil, peppermint oil, eucalyptus oil, citronella oil, lime oil, yuzu oil, jasmine oil, cypress oil, green tea essential oil, limonene, α-pinene, linalool, geraniol, phenylethyl alcohol, amyl cinnamic aldehyde, cumin aldehyde, and benzyl acetate, as well as fragrance components containing leaf alcohol or leaf aldehyde, known as the "scent of greenery."

[0037] <Formulation> The bed bug control agent of this embodiment can be used in, for example, the following formulation (product) forms depending on the location where resistant bed bugs may be present at the time of use, the surrounding conditions, etc. Examples of applicable formulation forms include oil solutions, emulsions, wettable powders, flowable agents (water suspensions, water emulsions, etc.), microcapsules, powders, granules, tablets, aerosols, sprays, carbon dioxide gas preparations, heated transpiration agents (fumigants, insecticidal coils, electric insecticidal mats, absorbent wick-type heated transpiration agents, etc.), non-heated transpiration agents (resin transpiration agents, fan-type transpiration agents, etc.), sheets, etc. Among these, from the viewpoint of ease of processing, use as an aerosol agent (aerosol product), spray agent (spray product), non-heated transpiration agent (non-heated transpiration product), or heated transpiration agent (heated transpiration product) is preferred.

[0038] The bed bug control agent of this embodiment can be used for contact control or space control, for example.

[0039] When the bed bug control agent is used for contact control, it can be attached to the floor, wall, and / or surface of an article (hereinafter referred to as the target surface) where resistant bed bugs may hide or wander. In this case, the bed bug control agent can be used in formulations such as powder, granules, aerosol product, spray product, heated evaporation product, non-heated evaporation product, sheet product, etc. By attaching (contacting) the bed bug control agent directly to the resistant bed bugs or to the target surface, the bed bug control agent can be brought into contact with the resistant bed bugs and the specific pyrethroid compound can be acted on. More specifically, for example, (1) powders and granules are applied by targeting resistant bed bugs or target surfaces, (2) aerosol products and spray products are sprayed by targeting resistant bed bugs or target surfaces, (3) heated evaporation products and non-heated evaporation products volatilize or scatter the bed bug control agent into space, which then adheres to the target surface within the space, and (4) sheet products are used to wipe the target surface or place the sheet product itself on the target surface, thereby directly or indirectly adhering the bed bug control agent to resistant bed bugs and controlling them. Powders, granules, aerosol products, spray products, and sheet products are preferred in that they can efficiently apply the bed bug control agent to resistant bed bugs and target surfaces, and aerosol products and spray products are more preferred in that they are particularly easy to use.

[0040] When bed bug control agents are used for spatial control, they can be sprayed or vaporized into spaces where resistant bed bugs may be present. In this case, the bed bug control agents can be used in formulations such as powders, granules, aerosol products, spray products, heated vaporization products, non-heated vaporization products, and sheet products. These products vaporize the bed bug control agent into the space, allowing the specific pyrethroid compound to act on the resistant bed bugs in that atmosphere. More specifically, aerosol products, spray products, heated vaporization products, and non-heated vaporization products can control resistant bed bugs by directly treating the space with the bed bug control agent by spraying or vaporizing it, while other formulations can be treated in the same manner as in (1) and (4) of the contact control method above, followed by vaporization of the bed bug control agent from the treated surface, thereby controlling resistant bed bugs. In addition, with regard to aerosol products, spray products, heated evaporation products, and non-heated evaporation products, the bed bug control agent can be applied not only directly to the air, but also to floors, walls, objects, etc., as in the contact control described above. The bed bug control agent can be slowly released from the surface of adhesion to control resistant bed bugs. Aerosol products, spray products, heated evaporation products, and non-heated evaporation products are preferred in that they can efficiently apply the bed bug control agent to the air, and aerosol products, spray products, heated evaporation products, and non-heated evaporation products are more preferred in that they are particularly easy to use. Heat-evaporated and non-heat-evaporated products can be installed directly on or near specific items such as floors, walls, and suitcases where resistant bed bugs may hide or wander (installation treatment process), thereby exposing resistant bed bugs to a higher concentration of the bed bug control agent, resulting in a higher control effect. This type of control is specifically referred to as "installation control."

[0041] In this way, by using a bed bug control agent for contact control or space control, the specific pyrethroid compound can be more appropriately applied to resistant bed bugs, thereby further enhancing the control effect.

[0042] When the bed bug control agent of this embodiment is used as an aerosol product, the aerosol product is mainly composed of a pressure-resistant container, a spray valve, and a spray nozzle. A spray button, which is an actuator for spraying a liquid medicine (concentrate) containing a specific pyrethroid compound, other optional ingredients, and various solvents, is connected to the spray valve, and a spray nozzle is provided with a spray port through which the liquid medicine is sprayed from the aerosol container to the outside. The spray valve may be a spray valve capable of normal continuous spraying or a metered-dose valve that sprays a fixed amount of liquid medicine per spray, with metered-dose valves being preferred. The spray volume of the liquid medicine when the spray button of a metered-dose aerosol product is pressed once is preferably set to 0.1 to 3 mL, more preferably 0.2 to 1 mL. Within this range, the spray particles sprayed from the metered-dose valve can effectively exert a control effect. The particle size of the spray particles is set to preferably 10 to 120 μm, more preferably 15 to 100 μm, and even more preferably 20 to 85 μm, as the 50% particle size (D50) of the volume cumulative distribution at 25° C. and a spray distance of 15 cm. Within these ranges, in the contact treatment or air treatment, the spray particles can reliably adhere to the surface of the object to be sprayed (including resistant bed bugs), or can act on the resistant bed bugs in a volatilized or vaporized state.

[0043] The diameter of the nozzle orifice provided in the spray nozzle is preferably set to 0.2 to 1.0 mm, and more preferably 0.7 to 1.0 mm. This range allows for an appropriate spray pattern, facilitates adhesion of spray particles to the target object (including resistant bed bugs), and allows the specific pyrethroid compound to act on resistant bed bugs directly or in a vaporized or evaporated state. In such aerosol products, the specific pyrethroid compound can be adjusted to contain 1 to 30 w / v % of the concentrate. Adjusting the amount within this range allows the specific pyrethroid compound to act on resistant bed bugs even with a small spray amount.

[0044] When the bed bug control agent of this embodiment is used as a spray product, a concentrate (chemical solution) containing the specific pyrethroid compound, other optional ingredients, and various solvents, and optionally a propellant, are selected and sealed in a pressure-resistant container or a trigger-type or pump-type spray container to obtain the spray product. The spray product can be sprayed onto floors, walls, and / or surfaces of objects where resistant bed bugs may hide or roam (contact treatment), or sprayed into spaces where resistant bed bugs may be present (space treatment). This allows the specific pyrethroid compound contained in the spray particles to act on resistant bed bugs. In such a spray product, the specific pyrethroid compound can be adjusted to contain 1 to 30 w / v % of the concentrate. Adjusting the concentration within this range allows the specific pyrethroid compound to act on resistant bed bugs even with a small spray amount.

[0045] When the bed bug control agent of this embodiment is used as a non-heating evaporation product, a stock solution (chemical solution) containing the specific pyrethroid compound, optional ingredients, and various solvents is applied to a support by coating, impregnation, kneading, or the like to obtain a non-heating evaporation product. The non-heating evaporation product can be prepared by volatilizing at room temperature or using a fan or other air-blowing device to place the bed bug control agent on or near floors, walls, and / or objects where resistant bed bugs may harbor or roam (installation treatment), or by volatilizing in spaces where resistant bed bugs may be present (space treatment). This allows the specific pyrethroid compound to act on resistant bed bugs. In such a non-heating evaporation product, the specific pyrethroid compound can be adjusted to contain 1 to 30 w / v % of the stock solution. Adjusting the concentration within this range allows the specific pyrethroid compound to act on resistant bed bugs even with a small amount supported.

[0046] The support used in the non-heated evaporation product is not particularly limited, and examples thereof include clays such as kaolin, diatomaceous earth, bentonite, and acid clay; inorganic minerals such as talc, ceramic, and calcium carbonate; sublimable substances that are solid at room temperature such as trioxane, naphthalene, p-dichlorobenzene, camphor, and adamantane; paper, wool, silk, cotton, hemp, pulp, various polymers and nonwoven fabrics, cellulose foams, porous materials, etc. Examples of polymers include films, solid molded bodies, or fibrous molded bodies composed of polyethylene, polypropylene, acrylonitrile / butadiene / styrene copolymer (ABS), ethylene / vinyl acetate copolymer (EVA), ethylene / methyl methacrylate copolymer (EMMA), styrene-based diblock polymers, styrene-based triblock polymers, thermoplastic resin elastomers (TPE, TPO), etc.; silicone rubber or silicone-based resins. Among these, it is preferable to use sheet or plate-shaped paper, pulp, fibrous material, or felt as the carrier, since the liquid-absorbing carrier can be impregnated with the chemical solution and exhibit volatility through natural evaporation. To increase the thickness of these carriers, multiple thin sheets may be stacked. Furthermore, pulp boards and felts can be bent, perforated, or embossed to efficiently absorb the chemical solution while maintaining their shape. Alternatively, the chemical solution may be carried on an adhesive carrier provided with a sealing layer for adhesion. These carriers can be used directly or housed in a breathable container, and appropriate fixing means (adhesive stickers, hook-and-loop fasteners, hanging hooks, etc.) may be used during use.

[0047] When the bed bug control agent of this embodiment is used as a heat-transmitting product, a liquid-type (liquid-absorbent wick-type) heat-transmitting product can be obtained by placing a stock solution (chemical solution) containing the specific pyrethroid compound, other optional ingredients, and various solvents in a container and heating it with a heat source. Alternatively, a mat-type heat-transmitting product can be obtained by impregnating a support such as the one described above with the chemical solution and heating it with a heat source. The heat-transmitting product can be used to deposit the bed bug control agent on floors, walls, and / or surfaces of objects where resistant bed bugs may harbor or roam (contact treatment), or to transpire into spaces where resistant bed bugs may be present (space treatment). This allows the specific pyrethroid compound to act on resistant bed bugs. In such heat-transmitting products, the specific pyrethroid compound can be adjusted to contain 1 to 30 w / v % of the stock solution. By adjusting the amount to fall within this range, the specific pyrethroid compound can act on resistant bedbugs even with a small amount of the chemical solution.

[0048] When spatial treatment is performed using the bed bug control agent of this embodiment, the space to which it is applied is not particularly limited as long as it is a space where resistant bed bugs may be present, and may be an indoor space or an outdoor space, but among these, an indoor space is preferred in that it can more effectively exert the control effect. ３ Clearance less than 2.0 to 18.8 m ３ A small space of about 18.8 to 33.3 m, equivalent to a room of 4.5 to 8 tatami mats in size. ３ degree (area 7.5-13.3m ２ , height 2.2-3.0m), and the volume of the room is 33.3-66.6m, which is equivalent to a room of 8-16 tatami mats. ３ degree (area 13.3-26.6m ２ The bed bug control agent of this embodiment is particularly suitable for a spacious indoor space with a volume of 33.3 m and a height of 2.2 to 3.0 m. ３The product is highly effective in the following narrow spaces, small spaces, and indoor spaces, and is particularly effective in narrow spaces. Examples of narrow spaces include suitcases (or clothes in suitcases), closets, storage closets, dressers, cupboards, furniture, and gaps between furniture. Examples of narrow spaces include toilets, bathrooms, storage rooms, and car interiors. Examples of indoor spaces include living rooms, dining rooms, and warehouses.

[0049] [Method for controlling bed bugs] In the method for controlling bed bugs of this embodiment, the bed bug control agent is used to control resistant bed bugs.

[0050] One embodiment of the bed bug control method includes a contact treatment step of attaching the bed bug control agent to the surface of a floor, wall, and / or article where resistant bed bugs may hide or wander. In this case, a bed bug control agent in an appropriate formulation such as those exemplified above can be used, and for example, an aerosol, a spray, a heat evaporation formulation, etc. can be used. According to this bed bug control method, by attaching the bed bug control agent to the surface of a floor, wall, and / or article where resistant bed bugs may hide or wander, the bed bug control agent can be brought into contact with the resistant bed bugs to allow the specific pyrethroid compound to act. By carrying out this bed bug control method, it becomes possible to control resistant bed bugs. The treatment amount of the bed bug control agent is such that the amount of the specific pyrethroid compound attached to the surface to be controlled is 15 mg / m ２ It is preferable that the concentration is 20 mg / m or more. ２ More preferably, it is 50 mg / m or more. ２ When the bed bug control agent is for contact control, the treatment amount of the bed bug control agent is set so that the amount of the specific pyrethroid compound attached to the control target surface is within the above range, thereby making it possible to further enhance the contact control effect.

[0051] Another aspect of the bed bug control method includes a space treatment step of spraying or evaporating the bed bug control agent into a space where resistant bed bugs may be present. In this case, a bed bug control agent in an appropriate formulation such as those exemplified above can be used, and for example, an aerosol, a spray, a non-heated evaporative agent, a heated evaporative agent, etc. can be used. According to this bed bug control method, by spraying or evaporating the bed bug control agent into a space where resistant bed bugs may be present, the bed bug control agent is volatilized into the space, and the specific pyrethroid compound can act on the resistant bed bugs in that atmosphere. By implementing this bed bug control method, it is possible to control resistant bed bugs.

[0052] In particular, by carrying out an installation treatment step (installation control) in which a heated vaporization product or a non-heated vaporization product is installed as a space treatment near floors, walls and / or articles where resistant bed bugs may hide or wander, a higher concentration of the bed bug control agent can be exposed to the resistant bed bugs, thereby achieving a higher control effect. The amount of the bed bug control agent to be applied to the space to be controlled is set at 0.5 mg / m2. ３ It is preferable that the concentration is 1 mg / m or more. ３ More preferably, it is 3 mg / m or more. ３ More preferably, it is 10 mg / m or more. ３ In particular, when the bed bug control agent is applied to a floor, a wall, an object, or the like, the amount of the specific pyrethroid compound applied to the space to be controlled is preferably 1000 mg / m or more. ３ It is preferable that the concentration is 2000 mg / m or more. ３ More preferably, it is 3000 mg / m or more. ３ More preferably, it is 5000 mg / m or more. ３ When the bed bug control agent is for spatial control, the treatment amount of the bed bug control agent is set so that the treatment amount of the specific pyrethroid compound relative to the space to be controlled falls within the above range, thereby making it possible to further enhance the spatial control effect.

[0053] EXAMPLES The present invention will be described in more detail below with reference to examples and comparative examples, but the present invention is not limited to these examples.

[0054] [Ingredients used] (Insecticidal ingredients) ・Specific pyrethroid compounds: Profluthrin, Empenthrin ・Non-specific pyrethroid compounds: Transfluthrin, Metofluthrin, Permethrin ・Non-pyrethroid compounds: Methoxadiazone

[0055] (Solvent) Ketone-based solvent: Acetone Alcohol-based solvent: Ethanol Isopropanol

[0056] [Test insects] (Bed bugs) - Drug (pyrethroid) resistant bed bugs (resistant bed bugs, adults): Resistant bed bugs (I): Itami strain (a strain that is 30,000 times more resistant to permethrin than the susceptible strain [Nichikankyo strain]) Resistant bed bugs (II): Amagasaki strain (a strain that is 30,000 times more resistant to permethrin than the susceptible strain [Nichikankyo strain]) Resistant bed bugs (III): Osaka strain (a strain that is 30,000 times more resistant to permethrin than the susceptible strain [Nichikankyo strain]) - Susceptible bed bugs (non-resistant bed bugs): Nichikankyo strain

[0057] (German cockroaches) ・Pyrethroid-resistant German cockroaches (resistant cockroaches, adult females): Fukuchiyama strain (a strain that is 49 times more resistant to permethrin than the susceptible strain [Dainippon strain]) ・Susceptible German cockroaches (non-resistant cockroaches, adult females): Dainippon strain

[0058] Test Example 1: Control effect by contact treatment The control effect against resistant bed bugs when a bed bug control agent was contact treated was compared with the control effect against non-resistant bed bugs. In addition, the control effect against resistant and non-resistant cockroaches was evaluated using the same evaluation method.

[0059] <Examples 1 to 6, Comparative Examples 1 to 6, Reference Example 1> By blending insecticidal components and solvents according to the formulations shown in Tables 1 and 2, medicinal liquid bed bug control agents of Examples 1 to 6, Comparative Examples 1 to 6, and Reference Example 1 were obtained. Using the bed bug control agents of Examples 1 to 6, Comparative Examples 1 to 6, and Reference Example 1, the control effects of contact treatment on resistant bed bugs (resistant bed bug (I), resistant bed bug (II), resistant bed bug (III)), non-resistant bed bugs, resistant cockroaches, and non-resistant cockroaches were evaluated by the following evaluation method.

[0060] <Test for control effect by contact treatment> A glass petri dish with a diameter of 9 cm and a height of 2 cm (volume: 127.17 cm) was used. ３ =0.00012717m ３ ) was used. A liquid medicine was dropped onto a glass petri dish so that the insecticidal component treatment amount shown in Tables 1 and 2 was achieved, and the liquid medicine (insecticidal component) was spread over the entire bottom surface of the glass petri dish. Next, a predetermined number of test insects were placed on the bottom of the glass petri dish, and the test insects were brought into direct contact with the liquid medicine (insecticidal component). 24 hours after the test insects were placed, the test insects were collected into a plastic cup lined with filter paper. 72 hours after the test insects were placed (48 hours after collection), the number of dead test insects was counted, and the mortality rate (%) was calculated. The control effect was then evaluated according to the following criteria.

[0061] (Criteria) A: Mortality rate is 90% or more B: Mortality rate is 80% or more but less than 90% C: Mortality rate is less than 80%

[0062]

[0063]

[0064] Of Examples 1 to 6, which contained a specific pyrethroid compound as the insecticidal ingredient, Examples 1 to 3, 5, and 6 received an "A" rating (mortality rate: 100% or 90%) for control efficacy against resistant bed bugs (I) to (III) after contact treatment, demonstrating excellent control efficacy. Although control results against resistant bed bugs (I) to (III) were not evaluated in Example 4, given the relationship between Examples 1 to 3 containing 2 w / v% profluthrin and Example 5 containing 10 w / v%, and if a similar trend is observed between Example 4 containing 2 w / v% empenthrin and Example 6 containing 10 w / v%, it is presumed that Example 4, like Example 6, also has excellent control efficacy against resistant bed bugs (I) to (III). Based on these results, Examples 1 to 6 are considered to be effective against resistant bed bugs in general. Furthermore, Examples 1 to 3 demonstrated that the use of acetone, ethanol, or isopropanol as a solvent did not inhibit the control effect of the specific pyrethroid compound against resistant bed bugs, and demonstrated excellent control effect against resistant bed bugs (I) to (III). This suggests that the type of solvent does not affect the control effect against resistant bed bugs. While profluthrin was used as the specific pyrethroid compound in Examples 1 to 3, the fact that the type of solvent does not affect the control effect against resistant bed bugs is also likely to be true when a specific pyrethroid compound other than profluthrin is used.

[0065] In all of Examples 1 to 6, the control effect against non-resistant bed bugs was rated "A" (mortality rate: 100%), demonstrating that the specific pyrethroid compound has an excellent control effect not only against resistant bed bugs but also against non-resistant bed bugs.

[0066] Among Examples 1 to 6, the results of Examples 5 and 6 showed that when the content of the specific pyrethroid compound was relatively high, the control effect against resistant cockroaches was rated "C" (lethality rate in Example 5: 0%, lethal rate in Example 6: 10%), indicating extremely low control effect, whereas the control effect against non-resistant cockroaches was rated "A" (lethality rate: 100%), indicating excellent control effect. On the other hand, the results of Examples 1 to 3 showed that when the content of the specific pyrethroid compound was relatively low, the control effect against resistant cockroaches was rated "C" (lethality rate: 0%), indicating extremely low control effect, and furthermore, the control effect against non-resistant cockroaches was also rated "C" (lethality rate in Example 1: 7.5%, lethal rate in Example 2: 10%, lethal rate in Example 3: 10%), indicating extremely low control effect. This shows that when the content of the specific pyrethroid compound is so low that it is ineffective against non-resistant cockroaches, it is also ineffective against resistant cockroaches. Considering that the specific pyrethroid compound has excellent control effect against resistant bed bugs (I) to (III) as described above, even though it has almost no control effect even against non-resistant cockroaches, it is clear that when the content of the specific pyrethroid compound is relatively low, the control effect of the contact treatment is particularly high against bed bugs. While profluthrin was used as the specific pyrethroid compound in Examples 1 to 3, the above-mentioned effect of setting the specific pyrethroid compound at a low content (i.e., the effect of having a control effect against resistant bed bugs despite not having a control effect even against non-resistant cockroaches) is likely to be similarly achieved when a specific pyrethroid compound other than profluthrin is used.

[0067] In contrast, Comparative Examples 1 to 6, which contained non-specific pyrethroid compounds, transfluthrin, metofluthrin, and permethrin, as insecticidal ingredients, were rated as "C" in terms of control effect against resistant bed bugs (I) (lethality rate for Comparative Examples 1 to 3: 0%, lethality rate for Comparative Example 4: 70%, lethality rate for Comparative Example 5: 20%, lethality rate for Comparative Example 6: 0%), demonstrating inferior control effect to Examples 1 to 6.

[0068] From the results of Comparative Examples 1 to 6, the control effect of the non-specific pyrethroid compound against non-resistant bed bugs was rated "A" (mortality rate: 100%), demonstrating excellent control effect.

[0069] The results of Comparative Examples 4 to 6 showed that the control effect of the non-specific pyrethroid compound against resistant cockroaches was rated "C" (lethal rate in Comparative Example 4: 10%, lethal rate in Comparative Example 5: 30%, lethal rate in Comparative Example 6: 15%), indicating extremely low control effect, whereas the control effect against non-resistant cockroaches was rated "A" (lethal rate: 100%), indicating excellent control effect.

[0070] Generally, the larger the insect, the less effective the pesticide, while the smaller the insect, the more effective the pesticide. Considering this, it is expected that Comparative Examples 4 to 6 would have a greater effect on resistant bed bugs than on resistant cockroaches (at least, this is the natural conclusion to draw). However, in reality, the pesticide effectiveness against resistant bed bugs in Comparative Examples 4 to 6 was rated "C," which was extremely low. Furthermore, despite the pesticide content being as high as that of Examples 5 and 6 (10 w / v%), Comparative Examples 4 to 6 were less effective against resistant bed bugs than Examples 5 and 6. Considering these points, the pesticide effectiveness against resistant bed bugs is considered to be specific to the specific pyrethroid compound.

[0071] Reference Example 1, which contained the non-pyrethroid compound methoxadiazone as the insecticidal ingredient, was rated "B" (lethal rate: 83%) in its control effect against resistant bed bugs (I), demonstrating inferior control effect to Examples 1 to 6. Methoxadiazone, which is generally considered to be effective against insects resistant to chemicals, exhibits a high control effect of "A" (lethal rate: 100%) against resistant cockroaches, but its control effect against resistant bed bugs (I) was found to be inferior to that of the specific pyrethroid compounds (profluthrin, empenthrin, etc.) of Examples 5 and 6.

[0072] As described above, it was shown that specific pyrethroid compounds have a higher control effect against resistant bed bugs than non-specific pyrethroid compounds and non-pyrethroid compounds in contact treatments. It was also shown that specific pyrethroid compounds tend to be effective not only against resistant bed bugs but also against non-resistant bed bugs. Furthermore, it was shown that when the specific pyrethroid compound is contained at a relatively high concentration, it is more effective against non-resistant cockroaches than against resistant cockroaches. In contrast, non-specific pyrethroid compounds are effective against non-resistant bed bugs, but are less effective against resistant bed bugs. Furthermore, it was shown that when the non-specific pyrethroid compound is contained at a relatively high concentration, it tends to be more effective against non-resistant cockroaches than against resistant cockroaches. From these findings, it can be understood that the relationship between the presence or absence of resistance and control effect in contact treatments tends to be completely different between bed bugs and cockroaches. Furthermore, the effect of contact treatment, in which the control effect against both resistant and non-resistant bed bugs is high, can be said to be an effect unique to the specific pyrethroid compound.

[0073] [Test Example 2] Control effect by spatial treatment The control effect against resistant bed bugs when the bed bug control agent was spatially treated was compared with the control effect against non-resistant bed bugs. In addition, the control effect against resistant and non-resistant cockroaches was evaluated using the same evaluation method.

[0074] <Examples 7 to 11, Comparative Examples 7 to 9, Reference Example 2> The bed bug control agents of Examples 7 to 11, Comparative Examples 7 to 9, and Reference Example 2 were obtained as medicinal solutions by blending the insecticidal component and the solvent according to the formulations shown in Tables 3 and 4. Using the bed bug control agents of Examples 7 to 11, Comparative Examples 7 to 9, and Reference Example 2, the control effects against resistant bed bugs (resistant bed bug (I), resistant bed bug (II), resistant bed bug (III)), non-resistant bed bugs, resistant cockroaches, and non-resistant cockroaches by spatial treatment were evaluated by the following evaluation method.

[0075] <Test of control effect by spatial treatment> A glass petri dish with a diameter of 9 cm and a height of 2 cm (volume: 127.17 cm) ３ =0.00012717m ３ ) and a lid capable of sealing the glass Petri dish were used. A drop of the insecticide solution was applied to the bottom of the lid (which becomes the top when the glass Petri dish is covered) at the insecticidal component treatment amount shown in Tables 3 and 4, and then spread over the entire bottom of the lid. A predetermined number of test insects were then placed on the bottom of the glass Petri dish, which was then sealed, and the insecticide solution (insecticidal component) was then exposed to the test insects. In this case, the insecticide solution did not come into direct contact with the test insects, and the insecticidal component volatilized from the solution acted on the test insects. After 24 hours had passed since the test insects were placed in the Petri dish, the lid was opened, and the test insects were collected in a plastic cup lined with filter paper. After 72 hours had passed since the test insects were placed in the Petri dish, the number of dead test insects was counted, and the mortality rate (%) was calculated. The control effect was then evaluated according to the following criteria.

[0076] (Criteria) A: Mortality rate is 90% or more B: Mortality rate is 80% or more but less than 90% C: Mortality rate is less than 80%

[0077]

[0078]

[0079] Examples 7 to 11, which contained a specific pyrethroid compound as an insecticidal ingredient, achieved an "A" rating (lethal rate: 100% or 90%) or a "B" rating (lethal rate: 85%) for control efficacy against resistant bed bugs (I) to (III) by spatial treatment, demonstrating excellent control efficacy. These results suggest that Examples 7 to 11 are effective against resistant bed bugs in general. Furthermore, the use of acetone, ethanol, or isopropanol as a solvent did not inhibit the control effect of the specific pyrethroid compound against resistant bed bugs, demonstrating excellent control efficacy against resistant bed bugs (I) to (III). This suggests that the type of solvent does not affect the control effect against resistant bed bugs.

[0080] Examples 7 to 11 were rated "A" for their control effect against non-resistant bed bugs (lethal rate: 100%), demonstrating that the specific pyrethroid compounds have excellent control effect not only against resistant bed bugs but also against non-resistant bed bugs.

[0081] In Examples 7 to 11, the control effect against resistant cockroaches was rated "C" (mortality rate: 0%), and the control effect against non-resistant cockroaches was also rated "C" (mortality rate: 0%), indicating that the specific pyrethroid compound had extremely low control effect against both resistant and non-resistant cockroaches. Considering that the control effect against non-resistant cockroaches was excellent when the content of the specific pyrethroid compound was relatively high in Examples 1 to 6 described above, it can be said that the control effect against non-resistant cockroaches differs between the contact treatment and the spatial treatment.

[0082] In contrast, Comparative Examples 7 to 9, which contained non-specific pyrethroid compounds, transfluthrin, metofluthrin, and permethrin, as insecticidal ingredients, were rated "C" (lethal rate: 0%) in terms of their control effect against resistant bed bugs (I), indicating that their control effect against resistant bed bugs (I) was extremely poor.

[0083] In Comparative Examples 7 and 8, the control effect against non-resistant bed bugs was rated "A" (mortality rate: 100%), and among the non-specific pyrethroid compounds, transfluthrin and metofluthrin showed excellent control effect against non-resistant bed bugs. On the other hand, the results of Comparative Example 9 showed that among the non-specific pyrethroid compounds, permethrin was rated "C" (mortality rate: 0%) in control effect against non-resistant bed bugs, indicating extremely poor control effect.

[0084] Comparative Examples 7 to 9 were rated "C" (mortality rate: 0%) for their control efficacy against resistant cockroaches, and also rated "C" (mortality rate: 0%) for their control efficacy against non-resistant cockroaches, indicating that non-specific pyrethroid compounds have extremely poor control efficacy against non-resistant cockroaches. It is clear that if a compound is not effective against non-resistant cockroaches, it will naturally be ineffective against resistant cockroaches. Considering the fact that, as mentioned above, the larger the insect, the less effective a compound is against it, and the smaller the insect, the more effective a compound is against it, it is expected that Comparative Examples 7 to 9 will have a greater control effect against resistant bedbugs than against resistant cockroaches (rated "C") (at least, this is a natural assumption). However, contrary to the above expectations, in reality, the control efficacy against resistant bed bugs in Comparative Examples 7 to 9 was rated "C," which was extremely low, similar to the control efficacy against resistant cockroaches (rated "C"). Furthermore, Comparative Examples 7 to 9 were inferior in control efficacy against resistant bed bugs to Examples 7 to 11 (rated "A" or "B"). Thus, in Comparative Examples 7 to 9, which used a non-specific pyrethroid compound, the control efficacy against both resistant cockroaches and resistant bed bugs was rated "C," whereas in Examples 7 to 11, which used a specific pyrethroid compound, the control efficacy against resistant cockroaches was rated "C," but the control efficacy against resistant bed bugs was rated "A" or "B." Considering these points, the control efficacy against resistant bed bugs in spatial treatment is considered to be unique to the specific pyrethroid compound.

[0085] Reference Example 2, which contained the non-pyrethroid compound metoxadiazone as the insecticidal ingredient, was rated "C" (lethality rate: 0%) for its control effect against resistant bed bugs (I), indicating that its control effect against resistant bed bugs was extremely poor. Reference Example 2 also received a "C" rating (lethality rate: 0%) for its control effect against non-resistant bed bugs, resistant cockroaches, and non-resistant cockroaches, indicating that its control effect against non-resistant bed bugs, resistant cockroaches, and non-resistant cockroaches was extremely poor.

[0086] As described above, in spatial treatments, as in contact treatments, specific pyrethroid compounds were shown to have a higher control effect against resistant bed bugs than non-specific pyrethroid compounds and non-pyrethroid compounds. Furthermore, it was also shown that specific pyrethroid compounds tend to have a high control effect not only against resistant bed bugs, but also against non-resistant bed bugs. Therefore, the high control effect against both resistant and non-resistant bed bugs, not only in contact treatments but also in spatial treatments, can be said to be an effect unique to specific pyrethroid compounds.

[0087] On the other hand, as mentioned above, contact treatment has a high control effect against non-resistant cockroaches, while spatial treatment has a low control effect against non-resistant cockroaches. In terms of control effect against other insects, the tendency of the control effect of spatial treatment is different from that of contact treatment.

[0088] The bed bug control agent and bed bug control method of the present invention are effective in controlling resistant bed bugs, and can be suitably used in particular in places where resistant bed bugs live and where they may hide or roam.

Claims

1. A bed bug control agent for controlling resistant bed bugs, having a vapor pressure of 6.6661 x 10 at 25°C. －３ A bed bug control agent containing a specific pyrethroid compound having a viscosity of 100 Pa or more.

2. A bed bug control agent according to claim 1, wherein the specific pyrethroid compound is profluthrin and / or empenthrin.

3. A bed bug control agent according to claim 1 or 2, which is for contact control or spatial control.

4. A bed bug control agent according to claim 1 or 2, wherein the amount of the specific pyrethroid compound is 1 to 30 w / v %.

5. The bed bug control agent is for contact control, and the treatment amount is such that the amount of the specific pyrethroid compound attached to the target surface is 15 mg / m ２ The bed bug control agent according to claim 1 or 2, wherein the above-mentioned is set.

6. The bed bug control agent is for spatial control, and the treatment amount is 1000 mg / m of the specific pyrethroid compound for the space to be controlled. ３ The bed bug control agent according to claim 1 or 2, wherein the above-mentioned is set.

7. A bed bug control method for controlling resistant bed bugs, comprising a contact treatment step of applying the bed bug control agent described in claim 1 or 2 to the surface of a floor, wall and / or object where the resistant bed bugs may hide or wander.

8. A bed bug control method for controlling resistant bed bugs, comprising a spatial treatment step of spraying, evaporating or vaporizing the bed bug control agent described in claim 1 or 2 in a space where the resistant bed bugs may be present.

9. A bed bug control method as described in claim 8, wherein the spatial treatment step includes an installation step of installing the bed bug control agent or a drug carrier containing the bed bug control agent on floors, walls and / or objects, or in the vicinity thereof, where the resistant bed bugs may hide or wander.