Composition for preventing hair loss or stimulating hair sprouting comprising mixed extracts of Euphorbia supina and Coffee

Abstract

The present invention relates to a composition for promoting hair growth or preventing hair loss comprising a mixed extract of *Bidens pilosa* and coffee. The mixed extract of *Bidens pilosa* and coffee according to the present invention has the effect of alleviating the progression of hair loss and promoting hair growth and regeneration. Therefore, the mixed extract of the present invention can be usefully utilized as a natural material for alleviating hair loss symptoms in the fields of functional cosmetics, health functional foods, and pharmaceuticals.

Description

Technology Field

[0001] The present invention relates to a composition for promoting hair growth or preventing hair loss comprising a mixed extract of silk grass and coffee. Background Technology

[0002] Although the human scalp contains approximately 80,000 to 90,000 hairs, it is normal for the average person to lose 50 to 70 hairs daily. However, if more than 100 hairs fall out excessively without any apparent reason after washing or sleeping, one may suspect alopecia. While the exact causes of such hair loss have not yet been precisely identified, it is generally known to be attributed to genetic factors, hormonal imbalances, excessive stress, seborrheic dermatitis, poor blood circulation in the scalp (tension of scalp muscles), dietary habits, nutritional and iron deficiencies, hair pulling (traction alopecia), atopic constitution, hair pollution (frequent perms, dyeing, use of hair dryers, etc.), air pollution, infectious and inflammatory diseases, chemical factors (alcohol, drugs, smoking), childbirth, and menopausal disorders.

[0003] In the human body, hair grows from hair follicles located in the skin. The hair follicle, where hair grows, is a complex organ composed of an inner root epithelial sheath, an outer root epithelial sheath, a hair shaft, and a hair matrix. It is characterized by the continuous repetition of cycles such as the growth phase, regression phase, and resting phase throughout a person's life. In particular, among the cells forming the hair follicle, dermal papilla cells play a crucial role in hair growth. During the growth phase, proliferation occurs among the constituent cells of the hair follicle, including keratinocytes of the matrix surrounding the dermal papilla. During the regression phase, growth of the hair follicle ceases, and apoptosis, condensation of the dermal papilla, and reorganization of the extracellular matrix take place. In the resting phase, which is the stage preparing the hair follicle to re-enter the growth phase, only the permanently persisting portion, including the raised area, remains.

[0004] Hair is divided into the root and the shaft, and hair grows within the hair follicle surrounding the root. Two important factors regulating the biological characteristics of the hair follicle are the outer root sheath (ORS) cells, which are follicular epithelium, and the mesenchymal-derived hair papilla (DP); hair grows and falls out through the repetition of the hair cycle. Hair undergoes three main stages: the growth phase (anagen), the regression phase (catagen), and the resting phase (telogen). Hair is formed and shed from the stratum corneum through the proliferation and differentiation of the epidermis and hair follicle, respectively. It is known that mesenchymal-derived transgenic amplification cells exist in the root sheath (DP) beneath the hair follicle to maintain the hair papilla of the growth-phase follicle. Various hormones (such as testosterone), cytokines, and growth factors are known to be involved in hair morphogenesis and the regulation of hair growth. An increase in the number and size of hair follicles was observed during the growth phase; unlike hair follicles in the resting phase which are located in the dermis, hair follicles in the growth phase are located in the deep subcutaneous tissue, so the increase in the number and size of hair follicles is closely associated with the growth phase.

[0005] With the recent rise in emphasis on appearance, interest in hair loss is also increasing. While various theories regarding the causes of hair loss have been discussed—including poor blood circulation, excessive male hormone activity, excessive sebum secretion, scalp function deterioration caused by peroxides and bacteria, genetic factors, aging, and stress—the clear cause of hair loss remains unknown.

[0006] The background description of the invention is provided to facilitate a better understanding of the present invention. The matters described in the background description should not be construed as an acknowledgment that they exist as prior art. The problem to be solved

[0007] Currently, the representative hair loss treatments approved by the U.S. Food and Drug Administration (FDA) are synthetic drugs such as topical minoxidil and oral finasteride, but several side effects are continuously being reported for these products. While finasteride works by inhibiting the conversion of the male hormone testosterone into dihydrotestosterone (DHT), a substance that causes hair loss, concerns have been raised regarding its potential to decrease male libido. Minoxidil, originally developed as a treatment for hypertension, was later developed as a hair growth stimulant following reports of hair growth promotion through follicle activation, but side effects such as various skin diseases are also being reported.

[0008] Natural substances useful for hair growth studied so far include soybeans ( Glycine linne , isoflavone), ginger ( Zingiber officinale , 6-gingerol), chili pepper ( Capsicum annuum ), Aloe ( Aloe arborescens ), licorice ( Glycyrrhiza glabra ), tea tree ( Camellia sinensis ), ginkgo tree( Ginkgo biloba ), avocado( Persea Americana ), White Polygonum multiflorum ( Polygonum multiflorum Although such natural products have been reported, despite efforts to utilize them, the commercialization of hair growth promoters or hair loss inhibitors is still minimal due to their low activity compared to pharmaceuticals.

[0009] Accordingly, the inventors of the present invention, through repeated research to develop a natural material with excellent hair growth-promoting and hair loss-preventing effects, confirmed that a mixed extract of silk grass and coffee alleviates the progression of hair loss and promotes hair growth, thereby completing the present invention.

[0010] Accordingly, the problem that the present invention aims to solve is, silk grass ( Euphorbia supina The present invention provides a cosmetic composition for promoting hair growth or preventing hair loss, comprising a mixed extract of ) and coffee as an active ingredient.

[0011] In addition, another problem that the present invention aims to solve is, silk grass ( Euphorbia supina The present invention provides a food composition for promoting hair growth or preventing hair loss, comprising a mixed extract of ) and coffee as an active ingredient.

[0012] In addition, another problem that the present invention aims to solve is, silk grass ( Euphorbia supina The present invention provides a feed composition for promoting hair growth or preventing hair loss, comprising a mixed extract of ) and coffee as an active ingredient.

[0013] In addition, another problem that the present invention aims to solve is, silk grass ( Euphorbia supina The present invention provides a pharmaceutical composition for the prevention or treatment of alopecia comprising a mixed extract of ) and coffee as an active ingredient.

[0014] The problems of the present invention are not limited to those mentioned above, and other unmentioned problems will be clearly understood by those skilled in the art from the description below. means of solving the problem

[0015] In order to solve the problem as described above, a silk grass according to one embodiment of the present invention ( Euphorbia supina A cosmetic composition for promoting hair growth or preventing hair loss is provided, comprising a mixed extract of ) and coffee as an active ingredient.

[0016] According to the features of the present invention, the mixed extract may be prepared by mixing a silk grass extract and a coffee extract, or by mixing silk grass and coffee seeds and then extracting.

[0017] According to another feature of the present invention, the silk grass extract may be a hot water extract.

[0018] According to another feature of the present invention, the silk grass extract may be prepared by mixing silk grass and water and then extracting at 60°C to 120°C for 60 minutes to 150 minutes.

[0019] According to another feature of the present invention, the silk grass extract may contain silk grass at a concentration of 20 g / L to 40 g / L.

[0020] According to another feature of the present invention, the coffee extract may be a hot water extract.

[0021] According to another feature of the present invention, the coffee extract may be prepared by redispersing soluble coffee powder in an aqueous medium.

[0022] According to another feature of the present invention, the coffee extract may contain soluble coffee powder at a concentration of 10 g / L to 20 g / L.

[0023] According to another feature of the present invention, the cosmetic composition may comprise 3 to 7 parts by volume of silk grass extract and 3 to 7 parts by volume of coffee extract.

[0024] According to another feature of the present invention, the formulation of the cosmetic composition may be a hair tonic, hair cream, hair lotion, hair shampoo, hair rinse, hair conditioner, hair spray, hair aerosol, pomade, powder, gel, hair pack, hair treatment, eyebrow growth agent, eyelash growth agent, eyelash nutrient, or ointment.

[0025] In order to solve the problem as described above, silk grass according to another embodiment of the present invention ( Euphorbia supina A food composition for promoting hair growth or preventing hair loss is provided, comprising a mixed extract of ) and coffee as an active ingredient.

[0026] According to a feature of the present invention, the formulation of the food composition may be a powder, granule, pill, tablet, capsule, candy, syrup, or beverage.

[0027] In order to solve the problem as described above, silk grass according to another embodiment of the present invention ( Euphorbia supina A feed composition for promoting hair growth or preventing hair loss is provided, comprising a mixed extract of ) and coffee as an active ingredient.

[0028] In order to solve the problem as described above, silk grass according to another embodiment of the present invention ( Euphorbia supina A pharmaceutical composition for the prevention or treatment of alopecia is provided, comprising a mixed extract of ) and coffee as an active ingredient. Effects of the invention

[0029] The mixed extract of *Bidens pilosa* and coffee according to the present invention has the effect of alleviating the progression of hair loss and promoting hair growth and regeneration. Therefore, the mixed extract of the present invention can be usefully utilized as a natural material for alleviating hair loss symptoms in the fields of functional cosmetics, health functional foods, and pharmaceuticals.

[0030] While existing hair loss treatments are based on synthetic drugs and have limitations such as reported systemic or local side effects upon long-term use, the present invention incorporates a naturally derived material as an active ingredient, thereby providing excellent biocompatibility and safety when applied to the human body and offering the effect of significantly reducing the possibility of side effects.

[0031] The effects according to the present invention are not limited to those exemplified above, and various other effects are included in this specification. Brief explanation of the drawing

[0032] FIG. 1 illustrates an example of manufacturing a hair growth shampoo according to one embodiment of the present invention. FIG. 2 illustrates an exemplary questionnaire for evaluating the hair growth effect and user satisfaction of a hair growth shampoo according to one embodiment of the present invention. Figure 3 illustrates the results of a clinical trial to confirm the hair growth promoting and hair loss prevention effects of a hair growth shampoo according to one embodiment of the present invention. Specific details for implementing the invention

[0033] The advantages and features of the present invention and the methods for achieving them will become clear by referring to the embodiments described below in detail together with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below but may be implemented in various different forms. These embodiments are provided merely to ensure that the disclosure of the present invention is complete and to fully inform those skilled in the art of the scope of the invention, and the present invention is defined only by the scope of the claims.

[0034] In the following, terms used within this specification are explained for clarity of explanation.

[0035] In this document, expressions such as "have," "can have," "include," or "can include" refer to the existence of the relevant feature (e.g., numerical values, functions, actions, or components, etc.) and do not exclude the existence of additional features.

[0036] In this document, "or" means "and / or" unless otherwise noted. Expressions such as "A or B," "at least one of A or / and B," or "one or more of A or / and B" may include all possible combinations of items listed together. For example, "A or B," "at least one of A and B," or "at least one of A or B" may refer to cases including (1) at least one A, (2) at least one B, or (3) both at least one A and at least one B.

[0037] In this document, '%' used to indicate the concentration of a specific substance is (w / w) % for solid / solid, (w / v) % for solid / liquid, and (v / v) % for liquid / liquid, unless otherwise noted.

[0038] The term “coffee extract” as used in the present invention refers to a substance containing components extracted from coffee seeds.

[0039] The term “coffee seed” used in the present invention refers to the seeds of trees of the genus Coffea, and includes not only green beans, which are seeds of trees of the genus Coffea harvested, with the shells and pulp removed and dried, but also roasted beans, which are green beans roasted at high temperatures to impart flavor and color.

[0040] As for the extraction method for obtaining a coffee extract according to the present invention, depending on the roasting and grinding conditions of the coffee beans, methods such as pressurized extraction, filtration extraction, maceration extraction, and decoction extraction may be appropriately selected and used, but are not limited thereto, and any extraction method known in the art may be applied without limitation.

[0041] Suitable solvents for extracting the extract from the above coffee seeds may include water (e.g., purified water, deionized water, soft water, hard water, reverse osmotic water, alkaline ionized water, deep water, etc.), ethanol, glycerin, butylene glycol, propylene glycol, etc., and water with a controlled mineral concentration within a specific range may be used to increase extraction efficiency, but is not limited thereto.

[0042] In the present invention, the coffee extract comprises all extracts obtained from coffee seeds (e.g., espresso, drip coffee, French press, cold brew, etc.), fractions and purified products, their dilutions, concentrates (e.g., cold brew concentrate, coffee syrup, etc.), or dried products (e.g., soluble coffee, coffee powder, etc.). Additionally, the dried products may be redispersed in a suitable medium as needed.

[0043] The terms “soluble coffee” or “instant coffee” used in the present invention generally refer to coffee products processed into a form that dissolves easily in hot water (soluble), and mean coffee prepared in a solid form (e.g., powder, granules, crystals, etc.) by drying an extract (or concentrate thereof) obtained from coffee seeds. The soluble coffee contains water-soluble components (caffeine, carbohydrates, fats, acids, polyphenols, etc.) extracted from coffee seeds and is characterized by high redispersibility as it does not contain coffee seed particles.

[0044] The term “roasting” as used in the present invention refers to the process of applying heat to green beans, during which the color of the green beans changes from green to brown and the unique taste and aroma of coffee are formed. Roasting is an important step in determining the quality and characteristics of coffee, and the taste of the coffee varies depending on the roasting time and temperature.

[0045] The term “hair growth promotion” as used in this invention refers not only to a hair growth function that generates new hair or promotes hair growth, but also to a function that facilitates the delay from the growth phase to the regression phase and enables existing hair to grow healthily.

[0046] The term “hair health” used in the present invention refers to the health condition of the hair, such as hair density, thickness, elasticity, and shine. Accordingly, in the present invention, “hair health promotion” refers to one or more hair health improvement effects selected from the group consisting of increasing hair thickness, strengthening hair elasticity, strengthening hair volume, and increasing the number of hairs.

[0047] The term “shampoo base” as used in the present invention comprises natural or synthetic surfactants and water, and includes ordinary optional ingredients such as water softeners, nutrients, viscosity modifiers, moisturizers, preservatives, emulsifiers, pH adjusters, hair conditioning agents, dyes, and fragrances to maintain the basic physical properties and quality of the shampoo.

[0049] In one aspect, the present invention is a silk grass ( Euphorbia supina The present invention relates to a cosmetic composition for promoting hair growth or preventing hair loss, comprising a mixed extract of ) and coffee as an active ingredient.

[0050] In one embodiment of the present invention, the mixed extract may be prepared by mixing a silk grass extract and a coffee extract, or by mixing silk grass and coffee seeds and then extracting, but is not limited thereto.

[0051] The silk grass extract and coffee extract according to the present invention may be obtained by extracting and separating from natural products using extraction and separation methods known in the art, and the "extract" defined in the present invention is a substance extracted using a suitable solvent, and includes, for example, crude extracts, extracts soluble in polar solvents, or extracts soluble in non-polar solvents.

[0052] As an extraction method, any one of the following methods may be selected and used: hot water extraction, cold maceration extraction, drop extraction, reflux cooling extraction, solvent extraction, ultrasonic extraction, microwave extraction, supercritical carbon dioxide extraction, enzyme extraction, pressurized extraction, high temperature and high pressure extraction, and a continuous extraction method combined with a fragrance capture process; preferably, hot water extraction may be selected and used.

[0053] As a suitable solvent for extracting an extract from the above natural product, any solvent that is acceptable in food science, pharmaceutical science, or cosmetic science may be used, and water or organic solvents may be used, but are not limited thereto. For example, various solvents such as polar solvents including water, ethanol, methanol, propanol, isopropanol, butanol, etc., alcohols having 1 to 4 carbon atoms; non-polar solvents such as hexane, ethyl acetate, chloroform, dichloromethane, benzene, toluene, acetone, carbon tetrachloride, ether, and methylene may be used alone or in combination.

[0054] In addition, the desired extract may undergo a conventional fractionation process or be purified using a conventional purification method. There are no limitations on the method for preparing the extract of the present invention, and any known method may be used. For example, the extract included in the composition of the present invention may be prepared in a powder state by additional processes such as vacuum distillation, freeze-drying, or spray-drying, from a primary extract obtained by the aforementioned hot water extraction or solvent extraction method. Furthermore, the primary extract may be further purified by using various chromatography methods such as silica gel column chromatography, thin layer chromatography, or high-performance liquid chromatography to obtain a further purified fraction. Accordingly, the extract of the present invention is a concept that encompasses all extracts, fractions, and purified products obtained at each stage of extraction, fractionation, or purification, as well as their dilutions, concentrates, or dried products.

[0055] In one embodiment of the present invention, the silk grass extract may be prepared by mixing silk grass and water and then extracting at 60°C to 120°C for 60 to 150 minutes, but is not limited thereto.

[0056] At this time, it is preferable to perform the extraction such that the volume of the extract is 0.65 times or less compared to the volume of the initial solvent input, and the extraction temperature and extraction time can be appropriately selected and changed by the user according to the desired concentration ratio.

[0057] In one embodiment of the present invention, the silk grass extract may contain silk grass at a concentration of 20 g / L to 40 g / L, but is not limited thereto.

[0058] In one embodiment of the present invention, the coffee extract may be prepared by redispersing soluble coffee powder in an aqueous medium, but is not limited thereto.

[0059] In one embodiment of the present invention, the coffee extract may contain soluble coffee powder at a concentration of 10 g / L to 20 g / L, but is not limited thereto.

[0060] In one embodiment of the present invention, the cosmetic composition may comprise 3 to 7 parts by volume of silk grass extract and 3 to 7 parts by volume of coffee extract, but is not limited thereto.

[0061] The “cosmetic composition” of the present invention can be prepared by including a cosmetically effective amount of the mixed extract of the silk grass and coffee of the present invention described above and a cosmetically acceptable carrier.

[0062] In this specification, “cosmetic effective amount” means an amount sufficient to achieve the hair growth-promoting or hair loss-preventing efficacy of the composition of the present invention described above.

[0063] The cosmetic composition may have a cosmetic or dermatologically acceptable medium or base. It may be provided in any formulation suitable for topical application, for example, as a solution, gel, solid, paste anhydrous product, emulsion obtained by dispersing an oil phase in an aqueous phase, suspension, microemulsion, microcapsule, microgranule, or ionic (liposome) and non-ionic vesicular dispersant, or in the form of a cream, skin toner, lotion, powder, ointment, spray, or concealer stick. These compositions may be prepared according to conventional methods in the art. The composition according to the present invention may also be used in the form of foam or as an aerosol composition further containing a compressed propellant.

[0064] The cosmetic composition according to one embodiment of the present invention is not particularly limited in its formulation and may be formulated into, for example, a hair tonic, hair cream, hair lotion, hair shampoo, hair rinse, hair conditioner, hair spray, hair aerosol, pomade, powder, gel, hair pack, hair treatment, eyebrow growth agent, eyelash growth agent, eyelash nutrient, or ointment, and preferably may be a hair shampoo.

[0065] In this case, when the formulation of the cosmetic composition of the present invention is a hair shampoo, the cosmetic composition of the present invention further includes a conventional shampoo base.

[0066] In addition, the cosmetic composition of the present invention comprises, with respect to 100 parts by volume of shampoo base, the active ingredient of the present invention, *Bidens pilosa* ( Euphorbia supina It may contain 10 to 25 parts by volume of a mixed extract of ) and coffee, but is not limited thereto.

[0067] In the case where the formulation of the cosmetic composition of the present invention is a paste, cream, or gel, animal fiber, plant fiber, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, or zinc oxide may be used as a carrier component.

[0068] When the formulation of the cosmetic composition of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, it may additionally include a propellant such as chlorofluorohydrocarbon, propane / butane, or dimethyl ether.

[0069] In the case where the formulation of the cosmetic composition of the present invention is a solution or an emulsion, a solvent, a solvating agent, or an emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol, or fatty acid ester of sorbitan.

[0070] In the case where the formulation of the cosmetic composition of the present invention is a suspension, liquid diluents such as water, ethanol, or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar, or tracanth may be used as carrier components.

[0071] In the case where the formulation of the cosmetic composition of the present invention is a cleansing product containing a surfactant, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide ether sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linolin derivative, or ethoxylated glycerol fatty acid ester, etc. may be used as a carrier component.

[0072] The cosmetic composition of the present invention can be applied to cosmetics such as skin toner, lotion, cream, essence, pack, foundation, color cosmetics, sunscreen, two-way cake, face powder, compact, makeup base, skin cover, eyeshadow, lipstick, lip gloss, lip fix, eyebrow pencil, lotion, etc., and to cleansing agents such as shampoo and soap.

[0073] In addition to the mixed extract of the silk grass and coffee, the cosmetic composition according to one embodiment of the present invention may further include functional additives and ingredients included in general cosmetic compositions. The functional additives may include ingredients selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high molecular weight peptides, high molecular weight polysaccharides, sphingolipids, and seaweed extracts.

[0074] In addition to the functional additives of the present invention, the cosmetic composition may also incorporate ingredients included in general cosmetic compositions as needed. Other ingredients included may include oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, UV absorbers, preservatives, disinfectants, antioxidants, plant extracts, pH adjusters, alcohols, colorants, fragrances, blood circulation promoters, cooling agents, antiperspirants, purified water, etc.

[0076] In one aspect, the present invention is a silk grass ( Euphorbia supina The present invention relates to a food composition for promoting hair growth or preventing hair loss, comprising a mixed extract of ) and coffee as an active ingredient.

[0077] The food composition of the present invention can be formulated into various forms such as powder, granules, pills, tablets, capsules, candies, syrups, and beverages, and added to food. There are no specific restrictions on the types of food. Examples of foods to which the mixed extract of *Bidens pilosa* and coffee of the present invention can be added include drinks, meat, sausages, bread, biscuits, rice cakes, chocolates, candies, snacks, confectionery, pizza, ramen, other noodles, chewing gum, dairy products including ice cream, various soups, beverages, alcoholic beverages, vitamin complexes, dairy products, and dairy processed products, and include both health foods and health functional foods in the conventional sense.

[0078] The term "health functional food" as used in this invention is synonymous with "food for special health use (FosHU)," and refers to a food with high medical or therapeutic effects that is processed to efficiently exhibit bio-regulatory functions in addition to nutritional supply. Here, "function" refers to obtaining useful effects for health purposes, such as regulating nutrients or physiological actions regarding the structure and function of the human body. The health functional food of this invention can be manufactured by methods commonly used in the industry, and during such manufacturing, raw materials and ingredients commonly added in the industry may be added. Furthermore, the formulation of the health functional food can be manufactured without restriction as long as it is a formulation recognized as a food. The health functional food of this invention can be manufactured in various forms of formulations. Unlike general pharmaceuticals, it uses food as a raw material, offering the advantage of not causing side effects that may occur with long-term use of pharmaceuticals. Additionally, due to its excellent portability, the health functional food of this invention can be consumed as an adjuvant to enhance hair growth promotion or hair loss prevention effects.

[0079] The aforementioned health functional food refers to a food that possesses active effects of maintaining or promoting health compared to general food, and health supplement food refers to a food intended for the purpose of health support. In some cases, the terms health functional food, health food, and health supplement food are used interchangeably.

[0080] Specifically, the above-mentioned health functional food is a food prepared by adding the composition of the present invention to food materials such as beverages, teas, spices, gum, and confectionery, or by encapsulating, powdering, or suspension, and means that consuming it brings about specific health effects. Unlike general medicines, it has the advantage of not having side effects that may occur when taking medicine for a long period of time because it is made from food.

[0081] The health food and health functional food compositions containing a mixed extract of *Bidangpul* and coffee according to the present invention may be added directly to food or used together with other food or food ingredients, and may be used appropriately according to conventional methods. The amount of the mixed extract of *Bidangpul* and coffee may be appropriately determined according to the purpose of use (for prevention or improvement). Generally, the amount of the above composition in the health food and health functional food may be added in an amount of 0.1 to 90 parts by weight of the total food weight. However, in the case of long-term consumption for the purpose of maintaining health or regulating health, the above amount may be less than the above range, and since there are no issues regarding safety, the active ingredient may be used in an amount greater than the above range.

[0082] The health food and health functional food compositions of the present invention contain a mixed extract of the present invention's silk grass and coffee as an essential ingredient in the indicated proportions, with no special restrictions on other ingredients, and may contain various flavoring agents or natural carbohydrates as additional ingredients, as in ordinary beverages. Examples of the natural carbohydrates described above include monosaccharides, e.g., glucose, fructose, etc.; disaccharides, e.g., maltose, sucrose, etc.; polysaccharides, e.g., dextrin, cyclodextrin, etc., and conventional sugars, and sugar alcohols such as xylitol, sorbitol, erythritol, etc. Natural flavoring agents (taumatin, stevia extract (e.g., rebaudioside A, glycyrrhizin, etc.)) and synthetic flavoring agents (saccharin, aspartame, etc.) other than those described above may be advantageously used. The proportion of the above natural carbohydrates is generally about 1 to 20 g, preferably about 5 to 12 g per 100g of the health functional food composition of the present invention.

[0083] In addition to the above, the health food and health functional food composition containing the mixed extract of silk grass and coffee of the present invention may contain various nutritional supplements, vitamins, minerals (electrolytes), flavoring agents such as synthetic flavoring agents and natural flavoring agents, coloring agents and thickening agents (cheese, chocolate, etc.), pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohol, carbonating agents used in carbonated beverages, etc. Furthermore, the health food and health functional food composition of the present invention may contain fruit pulp for the production of natural fruit juices, fruit juice beverages, and vegetable beverages.

[0084] In addition, the above-mentioned health food and health functional food compositions may include food additives such as preservatives (potassium sorbate, sodium benzoate, salicylic acid, sodium dehydroacetate, etc.), disinfectants (bleaching powder and high-grade bleaching powder, sodium hypochlorite, etc.), antioxidants (butylhydroxyanisole (BHA), butylhydroxytoluene (BHT), etc.), coloring agents (tar dyes, etc.), colorants (sodium nitrite, sodium nitrite, etc.), bleaching agents (sodium sulfite), seasonings (MSG, monosodium glutamate, etc.), sweeteners (dulcin, cyclamate, saccharin, sodium, etc.), flavorings (vanillin, lactones, etc.), leavening agents (alum, potassium hydrogen tartrate, etc.), reinforcing agents, emulsifiers, thickeners (sizing agents), coating agents, gum bases, antifoaming agents, solvents, and improvers. The above additives can be selected according to the type of food and used in appropriate amounts.

[0085] These ingredients may be used independently or in combination. Although the proportion of these additives is not that important, it is generally selected in the range of 0.1 to about 20 parts by weight per 100 parts by weight of the health food and health functional food composition containing the mixed extract of silk grass and coffee of the present invention.

[0087] In one aspect, the present invention is a silk grass ( Euphorbia supinaThe present invention relates to a feed composition for promoting hair growth or preventing hair loss, comprising a mixed extract of ) and coffee as an active ingredient.

[0088] As used in the present invention, the term "feed" refers to any natural or artificial prescribed food, single meal, etc., or the components of said single meal, intended for or suitable for animals to eat, consume, and digest.

[0089] The feed composition of the present invention can be prepared by adding a mixed extract of silk grass and coffee within an appropriate effective concentration range according to various feed manufacturing methods known in the art.

[0090] The feed composition of the present invention can be manufactured in various forms of feed known in the art, for example, in the case of pet food, it can be manufactured in formulations such as dry feed, wet feed, semi-wet feed, freeze-dried feed, and raw feed, and in the case of livestock feed, it can be manufactured in formulations such as concentrated feed, roughage, and special feed.

[0091] Furthermore, the above dry feed refers to a form of feed that is manufactured to have a low moisture content and possesses excellent storage stability and long-term shelf life by including extrusion molding and drying processes.

[0092] In addition, the above wet feed is manufactured to have a relatively high moisture content and is provided in the form of a can, pouch, or equivalent packaging, and refers to a feed that has excellent palatability and can assist in moisture intake.

[0093] In addition, the above semi-moist feed refers to a feed manufactured to have a moisture content intermediate between dry feed and wet feed, and is a form of feed that provides a soft texture and improved palatability.

[0094] In addition, the above freeze-dried feed refers to a feed manufactured by including a freeze-drying process that removes moisture under reduced pressure after freezing the raw material, and is a form of feed in which the nutritional components and flavor of the raw material are relatively well preserved.

[0095] Furthermore, raw feed refers to feed manufactured by processing raw materials into a raw or equivalent state without applying or minimizing heat treatment processes, meaning a form of feed that closely resembles natural food.

[0096] In addition, the above-mentioned concentrated feed refers to a feed that has a small volume and low crude fiber content but a total digestible nutrient (TDN) content of 50% or more, comprising: seed fruits including grains such as wheat, oats, and corn; bran, which is a byproduct remaining after grain refining and includes rice bran, wheat bran, and barley bran; oilseed meal, which is a byproduct obtained from extracting oil from soybeans, rapeseed, sesame, flaxseed, and coconut; residues such as residual starch, which is the main component of starch residue remaining after starch is removed from sweet potatoes, potatoes, etc.; fish meal; fish waste; fish soluble, which is a concentrated fresh liquid obtained from fish; meat meal; blood meal; feather meal; skim milk powder; and whey, which is the residue when producing cheese from milk or casein from skim milk. There are animal feeds such as dried whey, yeast, Chlorella, and seaweed.

[0097] In addition, the above roughage is a feed necessary to provide satiety as a basic feed for herbivorous livestock, and includes raw grass feed such as wild grass, pasture grass, and green cuts; root vegetables such as feed turnips, feed beets, and a type of turnip called lutea bearger; silage, which is a stored feed made by filling a silo with raw grass, green cut crops, and grains and fermenting them with lactic acid; hay made by cutting and drying wild grass and pasture grass; straw of livestock breeding crops; and leaves of legumes.

[0098] In addition, special feeds include mineral feeds such as shells and rock salt, urea feeds such as urea or its derivatives such as diuretic isobutane, feed additives and dietary supplements, which are substances added in small amounts to general feed to supplement components that are easily lacking when only natural feed ingredients are mixed or to improve the shelf life of the feed.

[0099] The feed composition of the present invention may further include components added to conventional feeds. Examples of components added to such feeds may include grain powder, meat powder, fish meal, legumes, and minerals. In the above, grain powder may include rice flour, wheat flour, barley flour, corn flour, etc. In the above, meat powder may include one or more meats selected from chicken, beef, pork, and ostrich meat. In the above, fish meal may include white fish meal produced using cod or pollock, or brown fish meal produced using anchovies, mackerel, tuna, sardines, etc. In the above, legumes may include soybeans, kidney beans, peas, black beans, etc. In the above, minerals may include macronutrient feeds such as sodium chloride, phosphates, and calcium salts, and micronutrient feeds such as iodine, iron, cobalt, and copper.

[0100] The feed composition of the present invention may include one or more selected from nutrients and inorganic substances in addition to the cereal powder, meat powder, fish meal, legumes, and minerals that are added to the conventional feed mentioned above to increase the nutritional value of the feed, and may include one or more selected from antifungal agents, antioxidants, anticoagulants, emulsifiers, and binders to prevent deterioration of feed quality.

[0101] The feed composition according to the present invention is not particularly limited and can be applied to any individual intended for promoting hair growth and preventing hair loss. The individual refers to animals, for example, non-primates (e.g., cattle, pigs, horses, cats, dogs, rats, and mice) and mammals including primates (e.g., monkeys, e.g., cynomolgous monkeys and chimpanzees). In another embodiment, the individual is a livestock animal (e.g., horses, cattle, pigs, etc.) or a pet animal (e.g., dogs or cats). Additionally, it is a fish, for example, flounder, sole, eel, freshwater eel, saltwater eel, rockfish, etc. In another embodiment, the individual is an insect, for example, horsefly, flower beetle, scarab beetle, mealworm, cricket, silkworm, scorpionfish, white silkworm, grub, earthworm, leech, centipede, scorpion, spider, etc.

[0102] In a specific embodiment of the present invention, the preferred individual may be selected from the group consisting of cattle, buffalo, sheep, goats, camels, reindeer, horses, donkeys, pigs, dogs, cats, rabbits, chickens, turkeys, pheasants, ostriches, geese, ducks, and quails as livestock, but is not limited thereto.

[0103] The dosage of the feed composition according to the present invention may be influenced by a number of factors such as the species, size, weight, and age of the individual. In principle, a typical dosage may be in the range of 0.001 to 1000 kg per individual / day. However, it is not limited thereto.

[0105] In one aspect, the present invention is a silk grass ( Euphorbia supina The present invention relates to a pharmaceutical composition for the prevention or treatment of alopecia comprising a mixed extract of ) and coffee as an active ingredient.

[0106] The term "prevention" above refers to any act that reduces the frequency or severity of the occurrence of pathological phenomena. Prevention may be complete or partial. In this case, it may refer to a phenomenon in which symptoms of hair loss within an individual are reduced compared to the case where the composition is not used.

[0107] The above "treatment" refers to any act of clinical intervention intended to alter the natural processes of the target or cell to be treated, and may be performed during the progression of a clinical pathological condition or to prevent it. The intended therapeutic effects may include preventing the onset or recurrence of the disease, alleviating symptoms, reducing all direct or indirect pathological consequences associated with the disease, preventing metastasis, slowing the rate of disease progression, alleviating or temporarily resolving the disease state, or improving the prognosis.

[0108] The pharmaceutical composition of the present invention is administered in a pharmaceutically effective amount. As used in the present invention, the term "pharmaceuticalally effective amount" refers to an amount sufficient to treat a disease with a reasonable benefit / risk ratio applicable to medical treatment and that does not cause adverse effects. The effective dose level may be determined based on factors including the patient's health status, type and severity of the disease, drug activity, sensitivity to the drug, method of administration, time of administration, route of administration and elimination rate, duration of treatment, drugs used in combination or concurrently, and other factors well known in the medical field. The composition of the present invention may be administered as an individual therapeutic agent or in combination with other therapeutic agents, may be administered sequentially or simultaneously with conventional therapeutic agents, and may be administered as a single or multiple doses. Considering all of the above factors, it is important to administer an amount that obtains maximum effect with a minimum amount without adverse effects, and this can be easily determined by a person skilled in the art.

[0109] In the present invention, the term "individual" refers to an individual intended for the prevention or treatment of alopecia, and is not particularly limited to animals including humans, for example, non-primates (e.g., cattle, pigs, horses, cats, dogs, rats, and mice) and mammals including primates (e.g., monkeys, e.g., cynomolgous monkeys and chimpanzees). In some cases, it may be an individual excluding humans.

[0110] The composition according to the present invention may comprise a pharmaceutically effective amount of a mixed extract of *Euphorbia pekinensis* and coffee alone, or one or more pharmaceutically acceptable carriers, excipients, or diluents. In the above, "pharmaceuticalally effective amount" refers to an amount sufficient to prevent, improve, and treat the symptoms of alopecia. In the above, "pharmaceutically acceptable" refers to a composition that is physiologically acceptable and, when administered to humans, does not typically cause allergic reactions or similar reactions such as gastrointestinal disorders or dizziness.

[0111] Additionally, a composition comprising a pharmaceutically acceptable carrier may be one or more formulations selected from the group comprising oral formulations, topical preparations, suppositories, sterile injectable solutions, and sprays, such as various formulations including capsules, liquids, injections, soft capsules, granules, or tablets. When formulating, it may be prepared using diluents or excipients such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants. The above carrier, excipient, and diluent may be one or more selected from the group consisting of lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia gum, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, physiological saline, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, dextrin, calcium carbonate, propylene glycol and liquid paraffin, but are not limited thereto, and any conventional carrier, excipient, or diluent may be used. The above components may be added independently or in combination to the mixed extract of the active ingredients, which are *Bidens pilosa* and coffee.

[0112] In addition, the pharmaceutical composition of the present invention may have any one formulation selected from the group consisting of tablets, pills, powders, granules, capsules, suspensions, liquid formulations, emulsions, syrups, sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized formulations, and suppositories. Witepsol, macrogol, Tween 61, cacao oil, laurin oil, glycerol, gelatin, etc. may be used as the base for suppositories.

[0113] The mixed extract of silk grass and coffee of the present invention can be administered in various oral and parenteral formulations during clinical administration, and when formulated, it is prepared using diluents or excipients such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants.

[0114] Solid formulations for oral administration include tablets, pills, powders, granules, capsules, troches, etc., and these solid formulations are prepared by mixing at least one excipient, such as starch, calcium carbonate, sucrose, lactose, or gelatin, with one or more mixed extracts of the present invention of the silk grass and coffee. In addition, lubricants such as magnesium stirate talc are also used in addition to simple excipients. Liquid formulations for oral administration include suspensions, liquid formulations, emulsions, or syrups, and may include various excipients, such as humectants, sweeteners, flavorings, and preservatives, in addition to commonly used simple diluents such as water and liquid paraffin.

[0115] Preparations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories, etc. As non-aqueous solvents and suspensions, propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate may be used. As bases for suppositories, witepsol, macrogol, tween 61, cocoa paste, laurin paste, glycerol, gelatin, etc. may be used.

[0116] The pharmaceutical composition of the present invention may be administered by any device capable of delivering a mixed extract of *Euphorbia pekinensis* and coffee to target cells. Preferred modes of administration and formulations include intravenous injections, subcutaneous injections, intradermal injections, intramuscular injections, drip injections, etc. The injection may be prepared using aqueous solvents such as physiological saline solution and Ringer's gel solution, non-aqueous solvents such as vegetable oils, higher fatty acid esters (e.g., ethyl oleate), and alcohols (e.g., ethanol, benzyl alcohol, propylene glycol, glycerin, etc.), and may include a pharmaceutical carrier such as a stabilizer to prevent deterioration (e.g., ascorbic acid, sodium bisulfite, sodium pyrosulfite, BHA, tocopherol, EDTA, etc.), an emulsifier, a buffer to adjust pH, and a preservative to inhibit microbial growth (e.g., phenylmercury nitrate, thimerosal, benzalkonium chloride, phenol, cresol, benzyl alcohol, etc.).

[0117] The pharmaceutical composition of the present invention can also be provided in the form of an external preparation comprising a mixed extract of silk grass and coffee as an active ingredient.

[0118] When the pharmaceutical composition of the present invention is used as a topical application for the skin, it may additionally contain adjuvants commonly used in the field of dermatology, such as fatty substances, organic solvents, solvents, thickeners and gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic emulsifiers, nonionic emulsifiers, fillers, metal ion chelating agents, chelating agents, preservatives, vitamins, blockers, humectants, essential oils, dyes, pigments, hydrophilic activators, lipophilic activators, or lipid vesicles, and any other ingredients commonly used in topical applications for the skin. Furthermore, said ingredients may be introduced in amounts commonly used in the field of dermatology. When the pharmaceutical composition of the present invention is provided as a topical application for the skin, it may be in the form of an ointment, patch, gel, cream, or spray, but is not limited thereto.

[0119] The pharmaceutical composition of the present invention may further include pharmaceutically acceptable additives, wherein the pharmaceutically acceptable additives may include starch, gelatinized starch, microcrystalline cellulose, lactose, povidone, colloidal silicon dioxide, calcium hydrogen phosphate, lactose, mannitol, malt syrup, gum arabic, pregelatinized starch, corn starch, powdered cellulose, hydroxypropyl cellulose, Opadry, sodium starch glycolate, carnauba wax, synthetic aluminum silicate, stearic acid, magnesium stearate, aluminum stearate, calcium stearate, sucrose, dextrose, sorbitol, and talc. The pharmaceutically acceptable additive according to the present invention is preferably included in an amount of 0.1 to 90 parts by weight with respect to the composition, but is not limited thereto.

[0120] The term "administration" as used in the present invention means providing a specific composition of the present invention to an individual by any appropriate method.

[0121] In addition, the effective dosage of the mixed extract of *Bidens pilosa* and coffee of the present invention to the human body may vary depending on the patient's age, body weight, gender, form of administration, health condition, and degree of disease, and is generally about 0.001-100 mg / kg / day, preferably 0.01-35 mg / kg / day. Based on an adult patient weighing 70 kg, it is generally 0.07-7000 mg / day, preferably 0.7-2500 mg / day, and may be administered in divided doses once or several times a day at regular intervals according to the judgment of a doctor or pharmacist.

[0122] The pharmaceutical composition of the present invention may be used alone or in combination with methods using surgery, radiation therapy, hormone therapy, chemotherapy, or biological response modifiers.

[0124] The following examples will be explained in more detail. However, these examples are intended to illustrate one or more specific examples, and the scope of the present invention is not limited to these examples.

[0126] Example 1: Preparation of a hair growth shampoo containing silk grass extract and coffee extract

[0127] 1-1. Preparation of Silkweed Extract

[0128] Silk grass Euphorbia supina After washing, it was air-dried until completely dry. Then, 30 g of dried silk grass was placed in 1 L of water and hot water extracted at 100 ℃ for more than 1 hour until the final volume was 0.65 L or less. Subsequently, the extract was filtered through a Büchner funnel (B) equipped with a filter paper (Whatman No. 1 filter) having an average pore size of 11 μm. A hot water extract of *Bidens pilosa* was prepared by vacuum filtration using an uchner funnel.

[0130] 1-2. Preparation of Coffee Extract

[0131] The coffee extract was prepared by completely dissolving 15 g of commercially available soluble coffee powder (Dongseo Foods, South Korea) in 1 L of water maintained at 80 ℃.

[0133] 1-3. Preparation of Hair Growth Shampoo

[0134] First, the silk grass extract of Example 1-1 and the coffee extract of Example 1-2 were mixed in a 1:1 volume ratio. Then, the mixture of the silk grass extract and the coffee extract was mixed with a conventional shampoo base in a 9:1 volume ratio (shampoo base:mixture, v / v) to prepare a hair growth shampoo.

[0135] The finished hair growth shampoo has a dark brownish-black color and a liquid state similar to water. It has a soft scent of silk grass and coffee blended with an added surfactant base (see Fig. 1).

[0137] Example 2: Confirmation of Clinical Effects of Hair Growth Shampoo

[0138] 2-1. Experimental Design and Subject Selection

[0139] This study was conducted to evaluate the clinical efficacy of a hair growth shampoo containing silk grass and coffee ingredients as main ingredients. The subjects were adult men and women aged 18 years or older who had confirmed progression of hair loss within the past 6 months. Those with sensitive scalps or skin diseases, those taking specific medications (e.g., minoxidil, finasteride), or those receiving other hair loss treatments concurrently during the study period were excluded.

[0141] 2-2. Usage Method and Duration

[0142] Subjects used 20–30 mL per session, 5–7 times a week, for at least 8 weeks. The average duration of use was 14–23 weeks (longest 158 ​​days, shortest 101 days), and the effect was evaluated approximately 6 months after the end of use.

[0144] 2-3. Evaluation Method

[0145] Evaluations were performed under identical conditions before shampoo use and approximately 6 months after the discontinuation of use. For each subject, hair condition was assessed by hair count (hairs / 0.25 cm) before and after use. 2 ), hair thickness (μm), and scalp condition were measured, and subjective satisfaction and hair growth effects were additionally evaluated through a user survey (see Fig. 2). Photography was performed using a high-resolution camera at a fixed magnification, fixed distance (using a lens spacer), and identical white balance and exposure values, with each area at 0.25 cm 2 Measurements were taken based on a (5 mm × 5 mm) observation window. Hair thickness was determined by correcting the pixel-to-length conversion based on the scale bar in the same image, and then measuring the diameter of at least 30 randomly selected hair strands from each observation window.

[0147] 2-4. Clinical Results

[0148] As a result of analyzing the change in hair density before and after using hair growth shampoo, the average number of hairs (0.25 cm) 2The number of hairs increased from 28.5 before use to 36.0 after use, showing an average improvement of 26.3% (Table 1). In particular, Subject 1, who had severe hair loss, increased from 23 to 35, showing an improvement of 52.2% (see Figure 3).

[0150] division Hair density (pieces / 0.25 cm) 2 ) Subject 1 Subject 2 Subject 3 Subject 4 Subject 5 average Before use 23 30 - 32 29 28.5 After use 35 38 - 36 35 36.0 Improvement (%) 52.2 26.7 - 12.5 20.7 26.3

[0152] As a result of analyzing the change in hair thickness before and after using the hair growth shampoo, the hair thickness increased from an average of 38.3 μm before use to 44.5 μm after use, showing an average improvement of 16.2% (Table 2). In particular, Subject 1 showed an improvement of 25%, increasing from 32 μm to 40 μm (see Figure 3).

[0154] division Hair thickness (μm) Subject 1 Subject 2 Subject 3 Subject 4 Subject 5 average Before use 32 38 - 45 38 38.3 After use 40 45 - 50 43 44.5 Improvement (%) 25.0 18.4 - 11.1 13.1 16.2

[0156] As a result of analyzing changes in scalp condition before and after using the hair growth shampoo through a survey, an improvement in scalp condition was observed in all subjects (n=4) who participated in the survey. Before use, conditions such as sensitive oily scalp and seborrheic dandruff were identified, but after use, the condition changed to a relatively good or very healthy state (Table 4). The results of the user survey showed that over 85% gave positive evaluations regarding the improvement of scalp health, reduction in hair loss, and new hair growth; in particular, 100% of respondents gave positive answers regarding the reduction in hair loss and hair growth effects. In addition, product satisfaction received a 100% positive evaluation as "very satisfied" or "satisfied," and the intention to purchase and recommend the product upon launch was also found to be 100%.

[0158] division Subject 1 Subject 2 Subject 3 Subject 4 Subject 5 Before use sensitive oily skin Seborrheic dandruff - health sensitive oily skin After use Relatively good Significant reduction in dandruff - Very healthy Intellectual weakening User rating Increased elasticity, reduced hair loss Reduction of hair loss, hair growth - Reduction of hair loss, hair growth Reduction of hair loss, improvement of scalp, hair growth

[0160] The hair growth shampoo containing the silk grass extract and coffee extract of the present invention significantly increased the average number and thickness of hairs, and confirmed effects of improving scalp condition and reducing hair loss. In particular, in subjects with severe hair loss, an improvement in hair density of up to 52.2% and an increase in thickness of 25% were observed, and improvements in scalp health and the generation of new hair were reported in all subjects. These results suggest that the shampoo composition of the present invention is effective in preventing hair loss and promoting hair growth, and accordingly, it can be usefully utilized in the development of functional cosmetics, health functional food materials, and pharmaceuticals aimed at prevention and improvement of scalp health.

[0162] Although embodiments of the present invention have been described in more detail with reference to the attached drawings, the present invention is not necessarily limited to these embodiments and may be modified in various ways within the scope of the technical spirit of the present invention. Accordingly, the embodiments disclosed in the present invention are intended to explain, not limit, the technical spirit of the present invention, and the scope of the technical spirit of the present invention is not limited by these embodiments. Therefore, the embodiments described above should be understood as illustrative in all respects and not restrictive. The scope of protection of the present invention shall be interpreted by the claims below, and all technical spirits within an equivalent scope shall be interpreted as being included within the scope of rights of the present invention.

Claims

Claim 1 Silk grass ( Euphorbia supina A cosmetic composition for promoting hair growth or preventing hair loss, comprising a mixed extract of ) and coffee as an active ingredient. Claim 2 A cosmetic composition for promoting hair growth or preventing hair loss according to claim 1, wherein the mixed extract is prepared by mixing silk grass extract and coffee extract, or by mixing silk grass and coffee seeds and then extracting. Claim 3 In paragraph 2, the above-mentioned silk grass extract is a hot water extract, a cosmetic composition for promoting hair growth or preventing hair loss. Claim 4 A cosmetic composition for promoting hair growth or preventing hair loss according to claim 3, characterized in that the above-mentioned silk grass extract is prepared by mixing silk grass and water and then extracting at 60°C to 120°C for 60 to 150 minutes. Claim 5 A cosmetic composition for promoting hair growth or preventing hair loss according to claim 4, wherein the above-mentioned silk grass extract contains silk grass at a concentration of 20 g / L to 40 g / L. Claim 6 A cosmetic composition for promoting hair growth or preventing hair loss, wherein the coffee extract is a hot water extract in paragraph 2. Claim 7 A cosmetic composition for promoting hair growth or preventing hair loss according to claim 6, wherein the coffee extract is prepared by redispersing soluble coffee powder in an aqueous medium. Claim 8 A cosmetic composition for promoting hair growth or preventing hair loss according to claim 7, wherein the coffee extract comprises soluble coffee powder at a concentration of 10 g / L to 20 g / L. Claim 9 A cosmetic composition for promoting hair growth or preventing hair loss according to claim 1, wherein the cosmetic composition comprises 3 to 7 parts by volume of silk grass extract and 3 to 7 parts by volume of coffee extract. Claim 10 In claim 1, the formulation of the cosmetic composition is a hair tonic, hair cream, hair lotion, hair shampoo, hair rinse, hair conditioner, hair spray, hair aerosol, pomade, powder, gel, hair pack, hair treatment, eyebrow growth agent, eyelash growth agent, eyelash nutrient, or ointment, a cosmetic composition for promoting hair growth or preventing hair loss. Claim 11 Silk grass ( Euphorbia supina A food composition for promoting hair growth or preventing hair loss, comprising a mixed extract of ) and coffee as an active ingredient. Claim 12 In claim 11, the food composition for promoting hair growth or preventing hair loss is in the form of a powder, granule, pill, tablet, capsule, candy, syrup, or beverage. Claim 13 Silk grass ( Euphorbia supina A feed composition for promoting hair growth or preventing hair loss, comprising a mixed extract of ) and coffee as an active ingredient. Claim 14 Silk grass ( Euphorbia supina A pharmaceutical composition for the prevention or treatment of alopecia comprising a mixed extract of ) and coffee as an active ingredient.

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