PNA Automatic Synthesizer

Abstract

The present invention relates to an automatic PNA synthesizer comprising a configuration capable of automatically performing PNA synthesis, and more specifically, to an automatic PNA synthesizer comprising a case forming an internal receiving space, wherein the case comprises a material receiving section capable of individually receiving a plurality of materials, a material transfer section for transferring materials from the material receiving section, and a reaction section for receiving materials from the material transfer section, wherein the material transfer section can select materials from the material receiving section according to a required specific combination and stack them in the reaction section.

Description

Technology Field

[0001] The present invention relates to a PNA (Peptide Nucleic Acid) synthesizer, and more specifically, to an automatic PNA synthesizer comprising a configuration capable of automatically performing PNA synthesis. Background Technology

[0002] Peptide Nucleic Acid (PNA) is a synthetic nucleic acid that has a structure similar to DNA or RNA but consists of peptide bonds instead of a phosphate-sugar backbone. PNA possesses high stability and strong DNA / RNA binding affinity, and is utilized in molecular diagnostics, anticancer treatment, and gene regulation research.

[0003] In particular, PNA (Peptide Nucleic Acid) is a synthetic nucleic acid capable of binding complementarily to DNA / RNA, and due to its high stability and strong binding affinity, it can be widely utilized in molecular diagnostics.

[0004] PNA acts as a nucleic acid probe and can be used to detect specific gene sequences. PNA can bind to specific sequences in DNA or RNA to form a double helix structure. In this case, because PNA lacks a phosphate backbone, it exhibits less charge repulsion and possesses a stronger binding affinity than DNA probes of the same sequence. In the presence of a mutation, the binding affinity with PNA weakens, making mutation detection possible.

[0005] With the commercialization of these PNA-based molecular diagnostic kits, there is a need for large-scale use in hospitals and laboratories. To meet the demand for massive testing during infectious disease pandemics (e.g., COVID-19), it is crucial to reduce PNA production costs and ensure supply stability. In other words, given the superior advantages of PNA-based molecular diagnostic technology in terms of accuracy, sensitivity, and speed, mass production is essential for commercial utilization and medical diagnostic applications.

[0006] To this end, there is a need for optimization research and development to replace existing manual-based synthesis with high-efficiency automated equipment to increase production volume, reduce reaction time, and conserve reagents. Prior art literature

[0007] KR 10-2002-0023157 (2002.04.26) The problem to be solved

[0008] The present invention was devised to solve the aforementioned problems, and the objective of the present invention is to provide an automatic synthesizer for mass production of PNA synthesis.

[0009] In addition, the objective of the present invention is to provide an automatic synthesizer capable of stacking various combinations and performing reactions and syntheses simultaneously.

[0010] In addition, the objective of the present invention is to provide an automatic synthesizer capable of minimizing errors and other issues that may occur during the synthesis process. means of solving the problem

[0011] The present invention relates to an automatic PNA synthesizer comprising a case forming an internal receiving space, the synthesizer comprising: a material receiving section capable of individually receiving a plurality of materials inside the case; a material transfer section for transferring materials from the material receiving section; and a reaction section for receiving materials from the material transfer section. The material transfer section can select materials from the material receiving section according to a required specific combination and stack them in the reaction section.

[0012] In addition, the material receiving portion may include a plurality of material containers each receiving a plurality of materials, and a syringe corresponding to each material container into which the material transfer portion is inserted.

[0013] Additionally, the material receiving portion includes a fixing portion for fixing the syringe, and the fixing portion may include a fixing plate forming a fixing groove into which the syringe is inserted and penetrated, and a fixing jig for fixing the syringe by pressing it against the fixing groove.

[0014] Additionally, the fixing jig includes a contact jig formed to extend from the outside to the fixing groove, and the fixing groove may be formed to extend outward from the position where the syringe is inserted so as to allow the contact jig to be interposed.

[0015] In addition, the material receiving portion may be formed above the fixing portion and may include a mounting portion through which the syringe is passed and mounted.

[0016] Additionally, the mounting portion may include a mounting plate having a mounting groove in which the syringe can be individually mounted, and may further include a lifting portion capable of raising and lowering the mounting plate.

[0017] Additionally, the material receiving portion includes a container tray in which the material container is positioned to fit the location of the syringe, and the container tray may further include a slide rail that can be extracted or inserted from the case.

[0018] Additionally, the syringe comprises an outer tube into which material is injected and a plunger that forms pressure within the outer tube, and the material conveying unit may include a first grip that holds the outer tube and a second grip that holds the plunger.

[0019] Additionally, the first grip may include a first wing that is directly contacted and gripped by the outer tube, and a first latch that forms a slope in which the diameter changes as the first wing slides, and the second grip may include a second wing that is directly contacted and gripped by the plunger, and a second latch that forms a slope in which the diameter changes as the second wing slides.

[0020] In addition, the material conveying unit may include a height adjustment unit capable of adjusting the height of the second grip with respect to the first grip.

[0021] Additionally, the material transfer unit may further include an auxiliary tip formed at a location adjacent to where the syringe is gripped, which limits the depth into which the syringe or the first grip is inserted.

[0022] Additionally, the reaction unit may include a plurality of reactors on which materials transferred from the material transfer unit are stacked, an element tray disposed below the reactors to regulate temperature, and an eccentric plate disposed below the reactors to apply kinetic energy to the reactors.

[0023] In addition, the reaction unit may include a cooling plate that is coupled in contact with the element tray and cools the element tray.

[0024] In addition, the element tray forms a perforated element mounting portion, and the element mounting portion may be in contact with the cooling plate to mount an element that performs heat transfer between the reactors.

[0025] In addition, the cooling plate may include a central flow path that is penetrated and has a lower and upper portion communicating with each other, and a peripheral flow path formed around the central flow path and having a plurality of partitions to allow air to flow in the horizontal direction.

[0026] In addition, the cooling plate may include a planar portion formed between the surrounding flow paths and in contact with the element.

[0027] In addition, the bulkhead of the surrounding channel can form a height below the surface of the planar portion.

[0028] In addition, the reaction portion includes a heat sink formed at the bottom of the cooling plate and communicating with the central flow path, and the heat sink is formed by stacking a plurality of heat dissipation fins, and can form gaps between each heat dissipation fin through which air can flow.

[0029] In addition, the heat sink includes a passage that communicates with the central passage and is dug to a certain depth in the same direction, and the passage may communicate with the gap between the heat dissipation fins.

[0030] In addition, the above element may be a thermoelectric element.

[0031] In addition, the eccentric plate includes a main guide that is circularly penetrated and a main eccentric unit formed inside the main guide and coupled with the cooling plate, and the central axis of the main eccentric unit is arranged to be spaced apart from the central axis of the main guide at a certain distance so as to generate kinetic energy with respect to the reactor.

[0032] In addition, the eccentric plate may further include a plurality of auxiliary guides formed by circularly penetrating the periphery of the main guide, and an auxiliary eccentric unit formed inside the auxiliary guides and coupled with the cooling plate.

[0033] In addition, the main eccentric unit further includes a unit penetration hole formed through the center, and the unit penetration hole may communicate with the central flow path. Effects of the invention

[0034] The automatic PNA synthesizer according to the present invention has the advantage of being able to rapidly synthesize PNA in large quantities, thereby lowering production costs.

[0035] The PNA automatic synthesizer according to the present invention has the advantage of being able to perform the synthesis of various combinations in large quantities.

[0036] The PNA automatic synthesizer according to the present invention has the advantage of minimizing errors and inaccuracies that may occur during the transfer and stacking process.

[0037] The automatic PNA synthesizer according to the present invention has the advantage of being able to provide an optimal environment for PNA synthesis and kinetic energy to promote synthesis. Brief explanation of the drawing

[0038] FIG. 1 is a perspective view of an automatic PNA synthesizer according to the present invention. FIG. 2 is an enlarged view of an automatic PNA synthesizer according to the present invention. FIG. 3 is a perspective view of the material receiving portion of an automatic PNA synthesizer according to the present invention. FIG. 4 is an exploded view of the material receiving section of the PNA automatic synthesizer according to the present invention. FIG. 5 is a cross-sectional view of the material receiving portion of an automatic PNA synthesizer according to the present invention. FIG. 6 is a perspective view of the material transfer section of an automatic PNA synthesizer according to the present invention. FIG. 7 is a cross-sectional view of the material transfer section of an automatic PNA synthesizer according to the present invention. FIG. 8 is an exploded view of the syringe of the PNA automatic synthesizer according to the present invention. FIG. 9 is a perspective view of the reaction section of an automatic PNA synthesizer according to the present invention. FIG. 10 is an exploded view of the reaction section of the PNA automatic synthesizer according to the present invention. FIG. 11 is a cross-sectional view of the reaction section of an automatic PNA synthesizer according to the present invention. FIG. 12 is an exploded view and cross-sectional view of the reaction section of an automatic PNA synthesizer according to the present invention. Specific details for implementing the invention

[0039] Hereinafter, the technical concept of the present invention will be explained in more detail using the attached drawings. Prior to this, terms and words used in this specification and claims should not be interpreted as being limited to their ordinary or dictionary meanings. Instead, based on the principle that the inventor can appropriately define the concepts of terms to best describe their invention, they should be interpreted in a meaning and concept consistent with the technical concept of the present invention. Therefore, the embodiments described in this specification and the configurations illustrated in the drawings are merely the most preferred embodiments of the present invention and do not represent all aspects of the technical concept of the present invention; thus, it should be understood that various modifications capable of replacing them may exist at the time of filing this application.

[0040] FIGS. 1 and 2 show an enlarged view of the overall appearance and internal configuration of the PNA automatic synthesizer (10) according to the present invention. As shown in the figure, the PNA automatic synthesizer (10) according to one embodiment of the present invention may largely include a material receiving section (100), a material transfer section (200), and a reaction section (300).

[0041] More specifically, as illustrated, the PNA automatic synthesizer (10) may include a case (11) that forms an internal receiving space. The case (11) may provide a sealed receiving space that blocks external foreign substances so that each component for PNA synthesis is not contaminated, or may perform an insulating function to create an environment favorable for synthesis.

[0042] In addition, the interior of the above case (11) may include a material receiving section (100) capable of individually receiving a plurality of materials for PNA synthesis, a material transfer section (200) for transferring materials from the material receiving section (100), and a reaction section (300) for receiving materials from the material transfer section (200).

[0043] That is, the material receiving unit (100) individually receives different materials required for synthesis, and the material transfer unit (200) can perform the stacking process by sequentially transferring each material to the reaction unit (300).

[0044] At this time, the material transfer unit (200) can perform synthesis by selecting the material of the material receiving unit (100) according to a specific combination required, stacking it in the reaction unit (300), and creating an environment such as applying kinetic energy for synthesis, such as a suitable temperature and vibration or rotation, in the reaction unit (300).

[0045] At this time, referring to FIG. 2, the process of transporting the material can be performed while the material receiving part (100) and the reaction part (300) are fixed as shown, and the material transport part (200) moves back and forth, up and down, left and right along the transport rails (201, 202).

[0046] That is, the material transfer unit (200) can extract materials by grasping a syringe (132) protruding upward from the material receiving unit (100) and stack each material in the reactor (310) of the reaction unit (300) according to the required combination.

[0047] FIGS. 3 to 5 illustrate a material receiving section (100) of a PNA automatic synthesizer (10) according to the present invention. As illustrated, the material receiving section (100) may include a plurality of material containers (111) each receiving a plurality of materials, and a syringe (132) corresponding to each material container (111) into which a material transfer section (200) is inserted.

[0048] At this time, the syringe (132) is formed in such a way that a portion of it is inserted into the material container (111) and protrudes upward, so that the material transfer unit (200) can be inserted into the syringe (132) to extract the material.

[0049] At this time, since the material in the material container (111) may need to be refilled as it is consumed, the material container (111) and the syringe (132) may be designed to be fixed in a specific position so that the separation and insertion process between the syringe (132) and the material container (111) can be easily repeated.

[0050] Additionally, referring to FIGS. 4 and 5, the material receiving portion (100) may include a fixing portion (120) for fixing the syringe (132). The fixing portion (120) may include a fixing plate forming a fixing groove (122-1) into which the syringe (132) is inserted, and a fixing jig (123) for fixing the syringe (132) by pressing it against the fixing groove (122-1).

[0051] That is, the fixed part (120) is positioned above the material container (111) to prevent the inserted syringe (132) from shaking, thereby allowing the material transfer part (200) to be easily inserted.

[0052] In one exemplary design, the fixing part (120) may include a fixing base (121) that is wider than the fixing plate (122). The fixing base (121) may be fixed above the material container (111) and spaced apart from it. The fixing plate (122) may be attached to the fixing base.

[0053] Next, the fixing plate (122) forms a fixing groove (122-1) into which the syringe (132) is inserted, and the fixing groove (122-1) may be designed to extend to one side or the other side of the fixing plate (122) so that the fixing jig (123) can be interposed therein.

[0054] In addition, the fixing jig (123) may further include a contact jig (123-1) having a length corresponding to the plurality of fixing grooves (122-1) so that it can be interposed in the fixing groove (122-1) on one side or the other side of the fixing plate (122).

[0055] That is, the fixing jig (123) includes a contact jig (123-1) formed to extend from the outer side of the fixing plate (122) to the fixing groove (122-1), and the fixing groove (122-1) is formed to extend outward from the position where the syringe (132) is inserted so that the contact jig (123-1) can be interposed, thereby allowing the syringe (132) to be fixed by pressing it against the fixing groove (122-1).

[0056] Additionally, referring to FIGS. 3 and 4, the material receiving portion (100) may include a mounting portion (130) formed above the fixing portion (120) and through which the syringe (132) is mounted. The mounting portion (130) may be fixed or mounted with respect to the syringe (132). To this end, the mounting portion (130) may include a mounting plate (131) that forms a plurality of mounting grooves (131-1) into which the syringe (132) can be mounted.

[0057] At this time, the syringe (132) is designed with a shape in which the diameter widens toward the top, and the mounting groove (131-1) is formed with a diameter narrower than the top of the syringe (132) so that the syringe (132) can be caught.

[0058] At this time, the syringe (132) can be separated from or reinserted from the material container (111) by the mounting portion (130) moving up and down. To this end, the material receiving portion (100) may further include a lifting portion (140) so that the mounting portion (130) can move up or down relative to the material container (111). For example, the lifting portion (140) is formed to be fixed to the mounting plate (131) and has an external configuration separate from the material receiving portion (100), and includes applicable length adjustment means such as a linear motor or a hydraulic device to adjust the height of the mounting portion (130).

[0059] Additionally, referring to FIGS. 1 and 4, the material receiving portion (100) includes a container tray (110) in which the material container is placed to fit the position of the syringe (132), and the container tray (110) may further include a slide rail (112) that can be extracted or inserted from the case (11).

[0060] At this time, the container tray (110) may include an engraved groove as a means to fix the material container (111) at a specific position. Through this, the position of the material container (111) can be easily positioned at the location where the syringe (132) descends.

[0061] In addition, the container tray (110) can be combined with the case (11) by forming the slide rail (112). That is, the container tray (110) can be removed to the outside of the case (11), allowing the user to easily perform tasks such as replacing or replenishing materials.

[0062] FIGS. 6 to 8 illustrate a material transfer unit (200) and a syringe (132) of a PNA automatic synthesizer (10) according to the present invention. Referring together with FIG. 2, the material transfer unit (200) may include a transfer unit (240) for transferring the syringe (132) and a transfer rail (201, 202) that forms a guide to which the transfer unit (240) can move. The transfer rail (201) provides a guide that can move forward, backward, up, down, left, and right along the material transfer unit (200) to perform transfer and stacking operations.

[0063] For example, the transfer rails (201, 202) may include a first transfer rail (201) to which the transfer unit (240) is directly connected, and a second transfer rail (202) to which the first transfer rail (201) is connected. That is, the transfer unit (240) operates in the left-right direction on the first transfer rail (201), and the entire first transfer rail (201) operates in the front-back direction on the second transfer rail (202), so that as a result, the material transfer unit (200) can operate in the front-back, left-right, and up-down directions.

[0064] Referring to FIG. 8, the syringe (132) may include the form of a general syringe comprising an outer tube (132-1) into which material is injected and a plunger (132-2) that forms pressure within the outer tube (132-1). In this case, the outer tube (132-1) and the plunger (132-2) may each have a shape with one end protruding or an engraved shape as illustrated so as to be gripped by the material transfer unit (200).

[0065] At this time, the material transfer unit (200) may include a first grip (211) that grips the outer tube (132-1) and a second grip (212) that grips the plunger (132-2). That is, the material transfer unit (200) can form pressure within the outer tube (132-1) in such a manner that the first grip (211) and the second grip (212) each individually grip the outer tube (132-1) and the plunger (132-2).

[0066] To explain in more detail, referring to FIG. 7, the first grip (211) may include a first wing (211-2) that is in direct contact with and gripped by the outer tube (132-1), and a first latch (211-1) that forms a slope in which the diameter changes as the first wing (211-2) slides, and the second grip (212) may include a second wing (212-2) that is in direct contact with and gripped by the plunger (132-2), and a second latch (212-1) that forms a slope in which the diameter changes as the second wing (212-2) slides.

[0067] In addition, the material transfer unit (200) may include a height adjustment unit (230) capable of adjusting the height of the second grip (212) relative to the first grip (211). The height adjustment unit (230) may include an actuator (231) and a transfer jig (232) as illustrated. The actuator (231) provides power to the transfer jig (232) to move the first latch (211-1) coupled with the transfer jig (232) up and down. At this time, the first wing (211-2) can grip the outer tube (132-1) by sliding along the slope formed on the first latch (211-1) and changing its diameter.

[0068] At this time, when the position of the outer tube (132-1) is fixed to the first wing (211-2), the second latch (212-1) and the second wing (212-2) can form negative pressure inside the outer tube (132-1) and inject material by gripping the plunger (132-2) and moving it upward.

[0069] At this time, as illustrated, the second grip (212) may further include an elastic part (212-3), the elastic part (212-3) cushioning and restricting the upward movement of the second latch (212-1), and when the second wing (212-2) is raised, the second wing (212-2) slides along the slope formed on the second latch (212-1) and can grip the plunger (132-2).

[0070] In addition, the material transfer unit (200) may further include an auxiliary tip (220) formed adjacent to the first grip (211) and extending in the same direction as the syringe (132). The auxiliary tip (220) is configured with a damper in a shape shorter than the syringe (132) and can serve to limit or buffer the depth when the syringe (132) descends for extraction or stacking.

[0071] FIGS. 9 to 12 illustrate a reaction section (300) of a PNA automatic synthesizer (10) according to the present invention. Referring to FIG. 9, the reaction section (300) may largely comprise a plurality of reactors (310) on which materials transferred from the material transfer section (200) are stacked, a component tray (330) disposed below the reactors (310) to control the temperature, and an eccentric plate (350) disposed below the reactors (310) to apply kinetic energy to the reactors (310).

[0072] That is, the element tray (330) can create a temperature for the material stacked on the reactor (310) to be synthesized, and the eccentric plate (350) can apply kinetic energy such as vibration to promote the reaction of the stacked material.

[0073] At this time, the plurality of reactors (310) may include a reactor tray (320) that forms a slot to be fixed at a specific location so as to easily stack materials through the material transfer unit (200). The element tray (330) may be disposed at the bottom of the reactor tray (320). Referring to FIG. 10, the element tray (330) forms a perforated element mounting portion (331), and the element mounting portion (331) may be used to mount an element that performs heat transfer to the reactor (310).

[0074] In addition, the reaction unit (300) may include a cooling plate (340) that is coupled in contact with the element tray (330) and cools the element tray (330). The cooling plate (340) may include a central flow path (341) that is penetrated and has a lower and upper portion communicating with each other, and a peripheral flow path (342) formed around the central flow path (341) and formed with a plurality of partitions (342-1) to allow air to flow in a horizontal direction.

[0075] For example, as illustrated, the central channel (341) is formed to include a plurality of holes in the center of the cooling plate, and the peripheral channel (342) can be designed to extend horizontally outward in a cross shape relative to the central channel (341).

[0076] That is, air for cooling is delivered from below through the central channel (341), and the peripheral channel (342) can transfer air to the side to cool the peripheral area where the air moves.

[0077] At this time, a flat portion (343) is formed between the cross-shaped surrounding channels (342), and the flat portion (343) can form a flat surface so that the element mounted on the element tray (330) can be in close contact.

[0078] At this time, for example, the element mounted on the element tray (330) may be a thermoelectric element. That is, the temperature can be controlled by cooling one side and heating the other side through the thermoelectric element.

[0079] At this time, in order to increase the surface area where the cooling plate (340) can come into contact with the cooled air, the surrounding flow path (342) may include a plurality of partitions (342-1). The partitions (342-1) may be formed to extend in the same direction as the horizontal direction in which the air moves.

[0080] At this time, it is preferable that the partition wall (342-1) be formed at a height below the surface of the flat portion (343) so that the cooling plate (340) can be closely bonded to the element tray.

[0081] Additionally, referring to FIG. 11, the reaction unit (300) includes a heat sink (360) formed at the bottom of the cooling plate (340) and communicating with the central flow path (341), and the heat sink (360) may be designed to be formed by stacking a plurality of heat dissipation fins (362) and forming a gap between each heat dissipation fin (362) through which air can flow.

[0082] As described above, the heat sink (360) may include a passage (361) that is in communication with the central passage (341) and is dug to a certain depth in the same direction. The passage (361) is designed to be in communication with the gap (362) between the heat dissipation fins so that when air is introduced from the outside, the air cooled through the heat dissipation fins (362) can be delivered to the cooling plate (340) through the central passage (341).

[0083] At this time, as illustrated, the central flow channel (341) can be designed to extend downward from the cooling plate (340) to a certain depth and communicate directly with the flow channel (361).

[0084] Consequently, the reaction unit (300) introduces air between the heat dissipation fins (362) of the heat sink (360) through the blower unit (370) formed on the outside, and the air cooled by the heat dissipation fins (362) is delivered to the central flow path (341) through the flow channel (361) and to the peripheral flow path (342) of the cooling plate (340) to perform cooling on the element tray (330).

[0085] Additionally, referring to FIGS. 11 and 12, the reaction unit (300) may include an eccentric plate (350) between the cooling plate (340) and the heat sink (360). The eccentric plate (350) includes a main guide (351) that is circularly perforated and a main eccentric unit (380) formed inside the main guide (351) and coupled to the cooling plate (340), and the central axis of the main eccentric unit (380) is positioned to be spaced apart from the central axis of the main guide (351) at a certain distance so as to generate kinetic energy with respect to the reactor tray (320).

[0086] That is, the main eccentric unit (380) can generate vibrational energy by rotating inside the main guide (351) with a different axis. As a result, the main eccentric unit (380) is coupled with the cooling plate (340), and the element tray (330), reactor tray (320), and reactor (310) coupled to the upper part of the cooling plate (340) vibrate together, thereby promoting the synthesis of the material stacked on the reactor (310).

[0087] At this time, as illustrated in FIG. 12a, the main eccentric unit (380) may further include a unit through-hole (381) formed with a hollow center. That is, the central flow path (341) may be interposed in the unit through-hole (381) so as to protrude downward from the cooling plate (340) and communicate with the heat sink (360). Consequently, the cooling plate (340) may be configured to communicate with the heat sink (360) and be coupled to the main eccentric unit (380) to receive vibration energy.

[0088] Furthermore, the eccentric plate (350) may further include a plurality of auxiliary guides (352) formed by circularly penetrating the periphery of the main guide (351), and an auxiliary eccentric unit (390) formed inside the auxiliary guides (352) and coupled with the cooling plate (340). The auxiliary guides (352) and the auxiliary eccentric unit (390) may be additionally configured to solve the problem of reduced structural stability when the main eccentric unit (380) generates kinetic energy along a single axis. That is, according to the illustrated embodiment, the auxiliary guides (352) may be formed symmetrically in four directions with respect to the main guide (351). The auxiliary eccentric unit (390) is coupled with the cooling plate (340) and can move within the auxiliary guides (352) according to the movement of the main eccentric unit (380) through a central axis spaced apart from the central axis of the auxiliary guides (352).

[0089] Additionally, referring to FIG. 9, the reaction unit (300) may further include a vibration damping means (301) that is directly coupled to the interior of the case (11). The vibration damping means (301) may be made of a material such as rubber and fixed inside the case (11), and may perform the function of blocking vibrations generated in the reaction unit (300) from affecting the outside. Explanation of the symbols

[0090] 10: PNA Automatic Synthesizer 11 : Case 100 : Material receiving section 110: Container Tray 111 : Material container 112 : Slide rail 120 : Fixed part 121 : Fixed base 122 : Fixed plate 122-1 : Fixing groove 123: Fixing jig 123-1 : Contact Jig 130 : Mounting part 131 : Mounting plate 131-1 : Mounting groove 132 : Syringe 140 : Lifting section 200 : Material transfer section 201, 202: Transfer rail 211: 1st Grip 211-1 : 1st Latch 211-2 : 1st Wing 212 : 2nd grip 212-1 : Second Latch 212-2 : 2nd Wing 212-3 : Elastic part 220 : Auxiliary Tip 230 : Height adjustment part 231 : Actuator 232 : Transfer Jig 240: Transfer unit 300 : Reaction part 301: Dustproof means 310 : Reactor 320 : Reactor Tray 330 : Component tray 331 : Component mounting section 340 : Cooling plate 341 : Central Euro 342 : surrounding Euros 342-1 : Bulkhead 343 : Planar section 350 : Eccentric plate 351 : Main Guide 352 : Auxiliary Guide 380: Main eccentric unit 381 : Unit Penetration 390 : Auxiliary Eccentric Unit 360 : Heatsink 361 : Distribution Channel 362 : Heat sink fins 370 : Blower unit

Claims

Claim 1 A PNA automatic synthesizer comprising a case forming an internal receiving space, the material receiving section capable of individually receiving a plurality of materials inside the case; a material transfer section for transferring materials from the material receiving section; and a reaction section for receiving materials from the material transfer section; wherein the material transfer section selects materials from the material receiving section according to a required specific combination and stacks them in the reaction section. Claim 2 In claim 1, the material receiving portion comprises a plurality of material containers each receiving a plurality of materials and a syringe corresponding to each material container into which the material transfer portion is inserted, in a PNA automatic synthesizer. Claim 3 In paragraph 2, the material receiving portion includes a fixing portion for fixing the syringe, and the fixing portion includes a fixing plate forming a fixing groove into which the syringe is inserted and penetrated, and a fixing jig for fixing the syringe in close contact within the fixing groove, in a PNA automatic synthesizer. Claim 4 In paragraph 3, the fixing jig includes a contact jig formed to extend from the outside to the fixing groove, and the fixing groove is formed to extend outward from the position where the syringe is inserted so as to interpose the contact jig, in a PNA automatic synthesizer. Claim 5 In paragraph 3, the material receiving portion is formed above the fixing portion, and the PNA automatic synthesizer includes a mounting portion through which the syringe is passed and mounted. Claim 6 In claim 5, the above mounting part includes a mounting plate having a mounting groove in which the syringe can be individually mounted, and further includes a lifting part capable of raising and lowering the mounting plate. PNA automatic synthesizer. Claim 7 In paragraph 2, the material receiving portion includes a container tray in which the material container is positioned to fit the location of the syringe, and the container tray further includes a slide rail that can be extracted or inserted from the case, in a PNA automatic synthesizer. Claim 8 In paragraph 2, the syringe comprises an outer tube into which material is injected and a plunger that forms pressure within the outer tube, and the material transfer unit comprises a first grip that holds the outer tube and a second grip that holds the plunger, in a PNA automatic synthesizer. Claim 9 In claim 8, the first grip comprises a first wing that is directly contacted and gripped by the outer tube and a first latch that forms a slope in which the first wing slides and changes its diameter, and the second grip comprises a second wing that is directly contacted and gripped by the plunger and a second latch that forms a slope in which the second wing slides and changes its diameter, a PNA automatic synthesizer. Claim 10 In claim 8, the material transfer unit comprises a height adjustment unit capable of adjusting the height of the second grip relative to the first grip, in a PNA automatic synthesizer. Claim 11 In claim 8, the material transfer unit further comprises an auxiliary tip formed at a location adjacent to where the syringe is gripped, which limits the depth into which the syringe or the first grip is inserted, in a PNA automatic synthesizer. Claim 12 In claim 1, the reaction unit comprises a plurality of reactors on which materials transferred from the material transfer unit are stacked, an element tray disposed below the reactors to control the temperature, and an eccentric plate disposed below the reactors to apply kinetic energy to the reactors, thereby forming an automatic PNA synthesizer. Claim 13 In claim 12, the above reaction part is coupled in contact with the element tray and includes a cooling plate that cools the element tray, in a PNA automatic synthesizer. Claim 14 In claim 13, the element tray forms a perforated element mounting portion, and the element mounting portion is in contact with the cooling plate and is a PNA automatic synthesizer in which an element that performs heat transfer between the reactors is mounted. Claim 15 In claim 14, the PNA automatic synthesizer comprises a central flow path through which the cooling plate is penetrated and the lower and upper parts are in communication, and a peripheral flow path formed around the central flow path and forming a plurality of partitions to allow air to flow in a horizontal direction. Claim 16 In claim 15, the above cooling plate is a PNA automatic synthesizer comprising a planar portion formed between the surrounding fluid paths and in contact with the element. Claim 17 In Clause 16, the partition wall of the surrounding Euro forms a height below the surface of the planar portion of the PNA automatic synthesizer. Claim 18 In claim 16, the reaction portion includes a heat sink formed at the bottom of the cooling plate and communicating with the central flow path, and the heat sink is formed by stacking a plurality of heat dissipation fins, with a gap formed between each heat dissipation fin through which air can flow, in a PNA automatic synthesizer. Claim 19 In claim 18, the heat sink comprises a passage that communicates with the central flow path and is dug to a certain depth in the same direction, and the passage communicates with the gap between the heat dissipation fins. Claim 20 In Clause 14, the above element is a PNA synthesizer which is a thermoelectric element. Claim 21 In claim 15, the eccentric plate comprises a main guide that is circularly penetrated and a main eccentric unit formed inside the main guide and coupled with the cooling plate, and the central axis of the main eccentric unit is arranged to be spaced apart from the central axis of the main guide at a certain distance to generate kinetic energy with respect to the reactor. Claim 22 In claim 21, the PNA automatic synthesizer further comprises a plurality of auxiliary guides formed by circularly penetrating the eccentric plate around the main guide and an auxiliary eccentric unit formed inside the auxiliary guides and coupled with the cooling plate. Claim 23 In claim 21, the main eccentric unit further includes a unit through hole formed through the center, and the unit through hole communicates with the central flow path of the PNA automatic synthesizer.

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