Micro-mineral and plant complex-based Anti-inflammatory and regenerative cosmetic composition

Abstract

The present invention relates to a cosmetic composition for anti-inflammatory and regeneration-promoting effects based on a micromineral-plant complex, wherein the plant complex comprises Centella asiatica extract and the micromineral comprises at least one of silicon and zinc. According to the present invention, it is possible to manufacture a cosmetic composition having anti-inflammatory, antioxidant, and whitening effects.

Description

Technology Field

[0001] The present invention relates to a cosmetic composition that promotes anti-inflammation and regeneration, and more specifically, to a cosmetic composition that promotes anti-inflammation and regeneration based on a micromineral-plant complex comprising a plant extract and at least one micromineral among silicon and zinc. Background Technology

[0002] The contents described in this section merely provide background information regarding the present invention and do not constitute prior art.

[0003] Recently, consumers tend to prefer functional cosmetics that protect and improve skin health, rather than cosmetics that simply moisturize.

[0004] In particular, since skin aging is accelerated by external environmental factors such as air pollution, ultraviolet rays, blue light, and stress, antioxidants are a very important function and a key issue in the cosmetics market.

[0005] In addition, as melanin production is activated by UV exposure, leading to an increasing trend of freckles, blemishes, and pigmentation, whitening ingredients are becoming increasingly important.

[0006] In addition, as the wearing of masks increases due to COVID-19 and fine dust, skin irritation and inflammation are becoming more common issues. Consequently, consumer interest in cosmetics with skin-soothing and anti-inflammatory functions is rising.

[0007] Representative antioxidants include vitamin C, anti-inflammatory ingredients include madecassoside, and whitening ingredients include glutathione.

[0008] Registration number KR10-2183186B1 discloses a high-concentration vitamin C cosmetic composition, however, there is a problem that vitamin C is easily oxidized by air, light, heat, and moisture due to its instability.

[0009] Registration number KR10-2337357B1 discloses a cosmetic composition for skin regeneration containing madecassoside. However, madecassoside has the problem of being susceptible to oxidation and deterioration and being sensitive to changes in pH.

[0010] Registration No. KR10-1725101B1 discloses a cosmetic composition for whitening containing glutathione and a method for manufacturing the same. However, glutathione is a hydrophilic molecule and has the problem that it is difficult to absorb into the skin because it does not easily pass through the skin barrier. Prior art literature

[0011] KR10-2183186B1KR10-2337357B1KR10-1725101B1 The problem to be solved

[0012] The objective of the present invention is to provide an anti-inflammatory and regeneration-promoting cosmetic composition based on a micromineral-plant complex that has an anti-inflammatory effect and can promote regeneration due to its antioxidant effect. means of solving the problem

[0013] To achieve the above objective, a cosmetic composition based on a micromineral-plant complex according to one embodiment of the present invention for anti-inflammatory and regeneration-promoting purposes comprises Centella asiatica extract as the plant complex and at least one of silicon and zinc as the micromineral.

[0014] A cosmetic composition for anti-inflammatory and regeneration-promoting effects based on a micromineral-plant complex may comprise, for every 100 parts by weight of the cosmetic composition, 1 to 20 parts by weight of Centella asiatica extract, 0.5 to 10 parts by weight of zinc, and 1 to 20 parts by weight of silicon.

[0015] A cosmetic composition based on a micromineral-plant complex for anti-inflammatory and regeneration promotion may comprise, for every 100 parts by weight of the cosmetic composition, 6 to 10 parts by weight of Centella asiatica extract, 1 to 3 parts by weight of zinc, and 3 to 15 parts by weight of silicon.

[0016] The silicon in the anti-inflammatory and regenerative-promoting cosmetic composition based on a micromineral-plant complex may be dimethicone.

[0017] The zinc in the anti-inflammatory and regenerative-promoting cosmetic composition based on a micromineral-plant complex may be zinc pyrrolidone carboxylic acid. Effects of the invention

[0018] A cosmetic composition based on a micromineral-plant complex according to one embodiment of the present invention, which promotes inflammation and regeneration, can soothe and protect damaged skin.

[0019] In addition, the anti-inflammatory and regeneration-promoting cosmetic composition based on a micromineral-plant complex according to one embodiment of the present invention can promote skin regeneration by suppressing inflammation and promoting recovery.

[0020] In addition, a cosmetic composition based on a micromineral-plant complex according to one embodiment of the present invention, which promotes inflammation and regeneration, can provide a whitening effect on freckles, blemishes, and pigmentation. Specific details for implementing the invention

[0021] Hereinafter, embodiments of the present invention are described in detail so that those skilled in the art can easily implement the invention. However, the present invention may be embodied in various different forms and is not limited to the embodiments described herein.

[0022] Unless otherwise defined, technical and scientific terms used in the specification of this invention have the meanings commonly understood by those skilled in the art to which this invention pertains, and descriptions of known functions and configurations that could unnecessarily obscure the essence of the invention are omitted in the following description and accompanying drawings.

[0023] Additionally, the singular form used in the specification of the present invention may be intended to include the plural form unless specifically indicated otherwise in the context.

[0024] Additionally, units used in the specification of the present invention without special mention are based on weight, and for example, units of % or ratio mean weight % or weight ratio.

[0025] Furthermore, the numerical ranges used in the specification of the present invention include lower and upper limits and all values ​​within those ranges, intermediate values ​​derived from defined shapes and widths, all values ​​limited thereto, and all possible combinations of upper and lower limits of numerical ranges limited by different shapes. For example, if the molecular weight is 100 to 10,000 and specifically limited to 500 to 5,000, the numerical range of 500 to 10,000 or 100 to 5,000 should also be interpreted as being described in the specification of the present invention. Unless otherwise specifically defined in the specification of the present invention, values ​​outside the numerical range that may occur due to experimental error or rounding of values ​​are also included in the defined numerical range.

[0026] Furthermore, in the specification of the present invention, the expression “comprising” is an open description having an equivalent meaning to expressions such as “comprising,” “containing,” “having,” or “characterizing,” and does not exclude elements, materials, or processes not additionally listed. Also, the expression “substantially comprising…” means that other elements, materials, or processes not listed together with the specified elements, materials, or processes may be present in an amount that does not have an unacceptable significant effect on at least one basic and novel technical concept of the invention. Additionally, the expression “consists of” means that only the described elements, materials, or processes are present.

[0027] One embodiment of the present invention relates to a cosmetic composition based on a micromineral-plant complex comprising at least one of Centella asiatica extract, silicon, and zinc, for anti-inflammatory and regeneration-promoting purposes.

[0028] Microminerals may include zinc and silicon.

[0029] The plant complex may include Centella asiatica extract.

[0030] Centella asiatica is a perennial herb belonging to the Apiaceae family that grows in wetlands in Southeast Asia, India, China, and Africa. The main stem spreads horizontally, and there are two degenerate, scale-like leaves near the nodes where roots grow. The leaves are densely clustered at the nodes, kidney-shaped, 2 to 5 cm in diameter, with a glossy surface and blunt serrations along the edges, and petioles 4 to 20 cm long. Historically, it is also called "tiger grass" because tigers are said to have rolled in fields of this plant when they were wounded. Centella asiatica contains active ingredients such as madecassoside, madecassic acid, asiaticoside, and asiatic acid. Asiaticoside and madecassic acid are involved in the production and secretion of collagen, and consequently, it is known to be effective in regenerating damaged skin and improving the elasticity of the dermis. Accordingly, it is effective for soothing and healing the skin.

[0031] A cosmetic composition based on a micromineral-plant complex according to one embodiment of the present invention, which promotes inflammation and regeneration, comprises Centella asiatica and can thereby provide a powerful soothing and healing effect on the skin.

[0032] Accordingly, the present invention may include 1 to 20 parts by weight, 5 to 15 parts by weight, and 6 to 10 parts by weight of Centella asiatica extract per 100 parts by weight of the cosmetic composition.

[0033] Centella asiatica extract can be obtained by solvent extraction, supercritical extraction by reduced pressure and high temperature using carbon dioxide, and ultrasonic extraction, but is not limited thereto.

[0034] For example, the extraction solvent used in the solvent extraction method may be one or more selected from the group consisting of water, anhydrous or hydrated lower alcohols having 1 to 4 carbon atoms (e.g., methanol, ethanol, propanol, and butanol), propylene glycol, 1,3-butylene glycol, glycerin, acetone, dimethyl ether, ethyl acetate, butyl acetate, dichloromethane, chloroform, hexane, and mixtures thereof. For example, it may be ethanol, water, or a mixture thereof.

[0035] Zinc is known to inhibit 5α-reductase, an enzyme involved in converting testosterone into dihydrotestosterone (DHT). Since dihydrotestosterone binds to receptors in the sebaceous glands and stimulates them to increase sebum production, sebum production can be reduced by inhibiting 5α-reductase.

[0036] A micromineral-plant complex-based anti-inflammatory and regeneration-promoting cosmetic composition according to one embodiment of the present invention contains zinc, and accordingly, the anti-inflammatory and antibacterial functions of the cosmetic composition can be enhanced, thereby promoting exfoliation and regeneration of the skin.

[0037] Accordingly, the present invention may include zinc in an amount of 0.5 to 10 parts by weight, 0.5 to 8 parts by weight, 0.5 to 6 parts by weight, 0.5 to 5 parts by weight, 0.5 to 4 parts by weight, 0.5 to 3 parts by weight, 1 to 10 parts by weight, 1 to 8 parts by weight, 1 to 6 parts by weight, 1 to 5 parts by weight, 1 to 4 parts by weight, and 1 to 3 parts by weight, based on 100 parts by weight of the cosmetic composition.

[0038] Zinc can be used as a zinc compound, for example, one or more selected from the group consisting of zinc pyrrolidone carboxylic acid (Zinc, PCA), zinc gluconate, zinc lactate, and zinc ascorbyl phosphate (ZAP).

[0039] A micromineral-plant complex-based anti-inflammatory and regeneration-promoting cosmetic composition according to one embodiment of the present invention includes silicon, and accordingly, the anti-inflammatory and whitening functions of the cosmetic composition can be improved, thereby promoting skin regeneration and improving whitening functions.

[0040] Accordingly, the present invention may include silicon in an amount of 1 to 20 parts by weight, 1 to 19 parts by weight, 1 to 18 parts by weight, 1 to 17 parts by weight, 1 to 16 parts by weight, 1 to 15 parts by weight, 2 to 20 parts by weight, 2 to 19 parts by weight, 2 to 18 parts by weight, 2 to 17 parts by weight, 2 to 16 parts by weight, 2 to 15 parts by weight, 3 to 20 parts by weight, 3 to 19 parts by weight, 3 to 18 parts by weight, 3 to 17 parts by weight, 3 to 16 parts by weight, and 3 to 15 parts by weight, based on 100 parts by weight of the cosmetic composition.

[0041] Silicon is available in silicon compounds and silicon compounds in mineral form, and according to one embodiment of the present invention, silicon-based silicon may be used. As silicon-based silicon, one or more selected from the group consisting of dimethicone, cyclopentasiloxane, phenyltrimethicone, and amodimethicone may be used.

[0042] Additionally, the anti-inflammatory and regeneration-promoting cosmetic composition based on a micromineral-plant complex according to one embodiment of the present invention may further include other additives. Other additives may include moisturizers, anti-inflammatory agents, preservatives, emulsifiers, oils, thickeners, and pH adjusters.

[0043] Hydroxydecyl ubiquinone may be used as an anti-inflammatory agent, but is not limited thereto. The anti-inflammatory agent may be included in an amount of 0.5 to 1 weight part per 100 weight parts of the cosmetic composition.

[0044] Preservatives may be used to prevent the growth of microorganisms in the product. Phenoxyethanol, ethylhexylglycerin, 1,2-hexanediol, and hydroxyacetophenone may be used as preservatives, but are not limited thereto. The preservative may be included in an amount of 0.3 to 1 part by weight per 100 parts by weight of the cosmetic composition.

[0045] An emulsifier may be used for emulsion stability. Cetearyl alcohol and glyceryl stearate may be used as emulsifiers, but are not limited thereto. The emulsifier may be included in an amount of 3 to 7 parts by weight per 100 parts by weight of the cosmetic composition.

[0046] Oil may be used to supply oil. Jojoba oil and squalane may be used as oils, but are not limited thereto. The oil may be included in an amount of 3 to 8 parts by weight per 100 parts by weight of the cosmetic composition.

[0047] Thickeners may be used for formulation stability. Carbomer and xanthan gum may be used as thickeners, but are not limited thereto. Thickeners may be used in an amount of 0.1 to 0.5 parts by weight per 100 parts by weight of the cosmetic composition.

[0048] A pH adjuster may be used to maintain the optimal pH of the product, which is 5.5 to 6.5. Citric acid may be used as the pH adjuster, but is not limited thereto. The pH adjuster may be used in an amount of 0.1 to 0.3 parts by weight.

[0049] The present invention will be described in more detail below based on examples and comparative examples. However, the following examples and comparative examples are merely illustrative of the present invention and are not limited to the following examples and comparative examples.

[0050] Preparation Example 1.

[0051] Centella asiatica was washed with purified water and dried. Then, 200g of the powdered Centella asiatica was placed in 2.5L of a 70% acetone solution and boiled for 4 hours in a reflux extractor equipped with a cooling condenser. The mixture was then filtered through a 300-mesh filter cloth, and the residue was extracted once more using the same method. The extracts were combined, filtered through a Whatman No. 5 filter, and the solvent was removed using a vacuum concentrator. The mixture was then freeze-dried to produce dried Centella asiatica extract.

[0052] Preparation Example 2

[0053] Gold was washed with purified water and dried, then 200g of powdered gold was placed in 2.5L of 70% acetone solution and boiled for 4 hours in a reflux extractor equipped with a cooling condenser. The mixture was then filtered through a 300-mesh filter cloth, and the residue was extracted once more using the same method. Each extract was combined, filtered through a Whatman No. 5 filter, and the solvent was removed using a vacuum concentrator. The mixture was then freeze-dried to produce dried gold extract.

[0054] Preparation Example 3

[0055] Turmeric was washed with purified water and dried, then 200g of powdered turmeric powder was placed in 2.5L of 70% acetone solution and boiled for 4 hours in a reflux extractor equipped with a cooling condenser. The mixture was then filtered through a 300-mesh filter cloth, and the residue was extracted once more using the same method. Each extract was combined, filtered through Whatman No. 5 filter paper, and the solvent was removed using a vacuum concentrator. The mixture was then freeze-dried to produce dried turmeric extract.

[0056] The specific contents of the cosmetic compositions of Examples 1 to 6 and Comparative Examples 1 to 4 are shown in [Table 1] below.

[0057] According to one embodiment of the present invention, dimethicone was used as silicon, and zinc pyrrolidone carboxylic acid was used as zinc. Glycerin was used as a moisturizer.

[0058] division Composition (weight part) Example 1 Plant extract of Example 1 of preparation (5) Silicon (3) zinc (1) Glycerin (2) Phenoxyethanol (0.3) Glyceryl stearate (5) Jojoba oil (8) Xanthan Sword (0.5) Citric acid (0.2) purified water (75) Example 2 Plant extract of Example 1 of preparation (10) Silicon (3) zinc (1) Glycerin (2) Phenoxyethanol (1) Glyceryl stearate (5) Jojoba oil (5) Xanthan Sword (0.5) Citric acid (0.2) purified water (72.3) Example 3 Plant extract of Example 1 of preparation (10) Silicon (15) zinc (1) Glycerin (4) Phenoxyethanol (1) Glyceryl stearate (7) Jojoba oil (5) Xanthan Sword (0.5) Citric acid (0.3) purified water (56.2) Example 4 Plant extract of Example 1 of preparation (10) Silicon (3) Zinc (2.5) Glycerin (6) Phenoxyethanol (1) Glyceryl stearate (7) Jojoba oil (5) Xanthan Sword (0.5) Citric acid (0.3) purified water (64.7) Example 5 Plant extract of Example 1 of preparation (10) Silicon (3) zinc (5) Glycerin (6) Phenoxyethanol (1) Glyceryl stearate (7) Jojoba oil (5) Xanthan Sword (0.5) Citric acid (0.3) purified water (62.2) Example 6 Plant extract of Example 1 of preparation (10) Silicon (20) zinc (1) Glycerin (4) Phenoxyethanol (1) Glyceryl stearate (7) Jojoba oil (5) Xanthan Sword (0.5) Citric acid (0.3) purified water (51.2) Comparative Example 1 Plant extract of preparation example 2 (5) Silicon (3) zinc (1) Glycerin (2) Phenoxyethanol (0.3) Glyceryl stearate (5) Jojoba oil (8) Xanthan Sword (0.5) Citric acid (0.2) purified water (75) Comparative Example 2 Preparation Example 2 plant extract (10) Silicon (3) zinc (1) Glycerin (2) Phenoxyethanol (1) Glyceryl stearate (5) Jojoba oil (5) Xanthan Sword (0.5) Citric acid (0.2) purified water (72.3) Comparative Example 3 Plant extract of preparation example 3 (5) Silicon (3) zinc (1) Glycerin (2) Phenoxyethanol (0.3) Glyceryl stearate (5) Jojoba oil (8) Xanthan Sword (0.5) Citric acid (0.2) purified water (75) Comparative Example 4 Plant extract of Example 3 of preparation (10) Silicon (3) zinc (1) Glycerin (2) Phenoxyethanol (1) Glyceryl stearate (5) Jojoba oil (5) Xanthan Sword (0.5) Citric acid (0.2) purified water (72.3)

[0059] Below, the anti-inflammatory, antioxidant, and whitening functions of products prepared with the contents of Examples 1 to 6 and Comparative Examples 1 to 4 were evaluated and are shown in Table 2.

[0060] [Evaluation Method]

[0061] 1. Evaluation of anti-inflammatory efficacy

[0062] The anti-inflammatory effect was confirmed by using RAW 264,7 cells stimulated with LPS (LPS(+)) and those not stimulated (LPS(-)) as controls. The analysis was performed by measuring NO production. The nitrite concentration in the cell culture medium was measured using the Gries reagent. RAW 264,7 cells were placed in a 12-well plate with a cell count of 1 × 10 5Cells were seeded to a cell / well ratio and cultured to 80% confluence. Subsequently, the plant extracts of Examples 1 and 2 and Comparative Examples 1 to 4 were treated, respectively, and NO production was induced with LPS (100 ng / mL) for 24 hours. Afterward, the culture supernatant and grease reagent were mixed in a 1:2 ratio, and the amount of NO produced at 540 nm was measured using an ELISA reader. A standard curve was constructed using sodium nitrite (NaNO2) and used for NO measurement. The amount of NO produced as a percentage is shown in Table 2 below.

[0063] Sample classification Sample treatment concentration (μg / ml) NO production amount (%) LPS(-) 0 23 LPS(+) - 0 100 Example 1 50 85 100 71 Example 2 50 83 100 68 Comparative Example 1 50 90 100 85 Comparative Example 2 50 92 100 83 Comparative Example 3 50 91 100 84 Comparative Example 4 50 89 100 90 2-amino-4-picoline (positive control) 10 μg 29.3

[0064] As shown in [Table 2] above, it was confirmed that NO production was reduced in the examples containing the plant extract of Preparation Example 1 compared to Comparative Examples 1 to 4 containing the plant extracts of Preparation Example 2 and Preparation Example 3. From this, it can be confirmed that the anti-inflammatory activity of the Centella asiatica extract is excellent.

[0065] 2. Evaluation of Antioxidant and Whitening Efficacy

[0066] To evaluate the antioxidant and whitening efficacy of the cosmetic compositions of Examples 1 to 6 and Comparative Examples 1 to 4, wrinkle improvement efficacy and skin tone improvement effects were tested. The test method involved conducting a clinical trial to evaluate the efficacy of improving wrinkles around the eyes for 4 weeks after using the cosmetic compositions on a total of 50 subjects, and all 50 subjects completed the test without any dropouts. The subjects consisted of 50 women, comprising 20 in their 30s, 10 in their 40s, and 10 in their 50s.

[0067] Experiments on the efficacy of wrinkle improvement and pigmentation improvement were measured using the ANTHERA 3D device. The ANTHERA 3D is a device capable of measuring skin condition using a multi-wavelength LED light source, and it allows for 2D and 3D configuration and analysis by wavelength using a built-in program that enables 3D analysis of skin texture, wrinkles, and pigmentation.

[0068] The condition of the subjects' skin was measured 4 weeks after using the cosmetic compositions of Examples 1 to 6 and Comparative Examples 1 to 4. To accurately measure the subjects' skin condition, the use of basic cosmetics was prohibited starting 12 hours prior to the start of the test. After washing their faces with a cleanser provided by the examiner, the subjects applied the samples themselves twice a day, morning and evening, for 4 weeks, after which the areas around both eyes were measured using ANTHERA 3D. A square area measuring 10 cm * 10 cm was established as the ANTHERA 3D imaging zone, covering the entire orbit and the areas around both eyes. Once all measurements were completed, the statistical significance between the eye wrinkles and skin tone brightness measurements taken before and 4 weeks after the use of the cosmetic composition of the present invention was analyzed and verified using the Wilcoxon signed-rank test. The measured improvement rates for wrinkles and pigmentation are listed in [Table 3] below.

[0069] division Wrinkle improvement rate (%) Skin tone brightness improvement rate (%) Example 1 8.54 6.34 Example 2 10.78 9.45 Example 3 16.73 14.22 Example 4 9.54 15.78 Example 5 9.14 14.33 Example 6 12.89 11.30 Comparative Example 1 7.87 5.34 Comparative Example 2 7.29 6.27 Comparative Example 3 6.49 6.15 Comparative Example 4 8.53 4.92

[0070] As shown in [Table 3], it can be confirmed that the wrinkle improvement rate and skin tone brightness improvement rate of Examples 1 to 6 are superior to those of Comparative Examples 1 to 4. Accordingly, it is possible to confirm the regeneration-promoting and whitening functions according to one embodiment of the present invention.

[0071] The foregoing description is merely an illustrative explanation of the technical concept of the present invention, and those skilled in the art to which the present invention pertains will be able to make various modifications and variations within the scope of the essential characteristics of the present invention. Accordingly, the above-described embodiments are intended to explain, not limit, the technical concept of the present invention, and the scope of the technical concept of the present invention is not limited by these embodiments. The scope of protection of the present invention shall be interpreted by the claims, and all technical concepts within an equivalent scope shall be interpreted as being included within the scope of rights of the present invention.

Claims

Claim 1 A cosmetic composition for anti-inflammatory and regeneration-promoting effects based on a micromineral-plant complex, wherein the plant complex comprises Centella asiatica extract and the micromineral comprises at least one of silicon and zinc. Claim 2 A micromineral-plant complex-based anti-inflammatory and regeneration-promoting cosmetic composition according to claim 1, comprising, per 100 parts by weight of the cosmetic composition, 1 to 20 parts by weight of Centella asiatica extract, 0.5 to 10 parts by weight of zinc, and 1 to 20 parts by weight of silicon. Claim 3 In paragraph 2, a micromineral-plant complex-based anti-inflammatory and regeneration-promoting cosmetic composition comprising, with respect to 100 parts by weight of the cosmetic composition, 6 to 10 parts by weight of Centella asiatica extract, 1 to 3 parts by weight of zinc, and 3 to 15 parts by weight of silicon. Claim 4 A micromineral-plant complex-based anti-inflammatory and regeneration-promoting cosmetic composition according to any one of claims 1 to 3, wherein the silicon is dimethicone. Claim 5 A micromineral-plant complex-based anti-inflammatory and regeneration-promoting cosmetic composition according to any one of claims 1 to 4, wherein the zinc is zinc pyrrolidone carboxylic acid.