Implantable magnetic induction-based electrical stimulation patch and device comprising the same

Abstract

The present invention provides an implantable magnetic induction-based electrical stimulation patch and a device including the same. More specifically, the present invention provides an implantable magnetic induction-based electrical stimulation patch and a device including the same, which can deliver overall electrical stimulation to an injured site in the body by implementing the principle of magnetic induction in an implantable device and can be stably fixed even in tissues with high water content.

Description

Technology Field

[0001] The present invention relates to an implantable magnetic induction-based electrical stimulation patch and a device including the same. More specifically, the present invention relates to an implantable magnetic induction-based electrical stimulation patch and a device including the same, which can deliver overall electrical stimulation to an injured site within the body by implementing the principle of magnetic induction in an implantable device and can be stably fixed even in tissues with high water content. Background Technology

[0002] Medical electrical stimulation devices can be broadly classified into extracorporeal and implantable types. Extracorporeal types offer high safety and ease of use due to their non-invasive nature, but they suffer from low stimulation efficiency and limitations in stimulating deep tissues. Implantable types, on the other hand, allow for direct stimulation of target tissues, resulting in superior efficiency and precision; however, they have the disadvantages of requiring surgery and carrying a relatively high risk of infection and complications.

[0003] Meanwhile, the demand for spinal cord injury treatment is increasing worldwide. Globally, hundreds of thousands of people suffer spinal cord injuries every year due to various traumas such as traffic accidents, falls, and sports injuries. The resulting decline in motor function, loss of sensation, and paralysis of the autonomic nervous system are severely degrading the quality of life for patients. In particular, with the entry into an aging society, the incidence of degenerative neurological diseases is also increasing, leading to an explosive rise in the demand for effective treatment technologies for patients with chronic spinal cord injuries.

[0004] To date, spinal cord stimulation technologies have been dominated by two main methods: applying electrical stimulation from outside the body (extracorporeal stimulation device method) and inserting electrodes directly into the body (implantable device method). However, in the case of extracorporeal electrical stimulation, there is a high probability that stimulation cannot be specifically delivered to the site of injury, and stimulating only specific areas requires a large amount of energy and has limitations. Additionally, in the case of implantable devices, there is a disadvantage in that the spinal cord must be wrapped 360° to overcome anatomical limitations in order to stimulate the entire spinal cord. This process carries a high risk of secondary spinal cord injury. Therefore, as existing spinal cord injury recovery technologies have limitations such as difficulty in precise stimulation and the risk of spinal cord injury, there is an urgent need to develop sophisticated yet tissue-friendly alternative technologies and related spinal cord stimulation devices.

[0005] The global spinal cord injury treatment market was valued at $7.13 billion in 2023 and is expected to surpass approximately $11 billion by 2032, growing at a CAGR of 4.8%. Additionally, the spinal cord stimulation device market was valued at $2.74 billion in 2023 and is expected to grow at a CAGR of 7.9%. Consequently, the demand for technological advancements in spinal cord stimulation devices is also surging.

[0006] Therefore, there is a need to develop technology for tissue-friendly electrical stimulation devices that enable precise and sophisticated electrical stimulation to damaged areas within the body, such as the spinal cord.

[0007] As background technology of the present invention, Japanese published patent JP 2019-511286 A discloses an external ultrasound generating therapy device for the treatment of spinal cords and spinal nerves, a device equipped with said device, and a method using said device. The problem to be solved

[0008] The purpose of the present invention is to provide an implantable magnetic induction-based electrical stimulation patch and / or a device including the same that is tissue-friendly and capable of precise and sophisticated stimulation of damaged areas within the body, such as the spinal cord.

[0009] Another objective of the present invention is to provide an electrical stimulation patch and / or a device including the same that can ensure long-term stability even in damaged areas of the body with high moisture and movement.

[0010] Another objective of the present invention is to provide an electrical stimulation patch and / or a device comprising the same that can deliver electrical stimulation to a wide range of an organ without being attached to the entire damaged organ in the body.

[0011] Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims, and drawings. means of solving the problem

[0012] According to one aspect, an implantable electrical stimulation patch of the present invention comprises: a hydrogel bioadhesive layer attached to a body part; and one or more magnetic induction-based electrodes provided on one side of the hydrogel bioadhesive layer.

[0013] According to one embodiment, the hydrogel bioadhesive layer may be based on a polyacrylamide (PA) type, polyethylene glycol (PEG) type, hyaluronic acid (HA) type, alginate type, or polyvinyl alcohol (PVA) type polymer.

[0014] According to one embodiment, the elastic modulus of the hydrogel bioadhesive layer may be 1 MPa or less.

[0015] According to one embodiment, the magnetic induction-based electrode may be a metal thin film, a liquid metal, a conductive polymer, or a mixed type electrode containing one or more of these.

[0016] According to one embodiment, the magnetic induction-based electrode may include a circular coil composed of a conductive material.

[0017] According to one embodiment, the circular coil may have one or more circular coils and / or a predetermined arrangement of the circular coils depending on the damaged area.

[0018] According to one embodiment, when there are multiple circular coils, at least one of the diameter, line width, number of turns, spacing, or arrangement position of each circular coil may be different, so that each circular coil forms a different magnetic induction range.

[0019] According to one embodiment, one or more insulating layers may be provided between the hydrogel bioadhesive layer and the magnetic induction-based electrode; and / or on one side of the magnetic induction-based electrode.

[0020] According to one embodiment, the hydrogel bioadhesive layer may contain a drug.

[0021] According to one embodiment, the electrical stimulation patch of the present invention may be for improving or treating spinal cord injury.

[0022] According to one embodiment, the electric stimulation patch of the present invention can be inserted into the body and attached to a part of the damaged area.

[0023] According to another aspect, the electric stimulation device of the present invention comprises an electric stimulation patch comprising: a hydrogel bioadhesive layer attached to a part of the body; and one or more magnetic induction-based electrodes provided on one side of the hydrogel bioadhesive layer.

[0024] According to one embodiment, the electrical stimulation device of the present invention may include: a hydrogel bioadhesive layer attached to a part of the body; one or more magnetic induction-based electrodes provided on one side of the hydrogel bioadhesive layer; and a power source connected to the magnetic induction-based electrodes via wired and / or wireless connections.

[0025] According to one embodiment, the electrical stimulation device of the present invention can induce the recovery of nerve cells.

[0026] According to one embodiment, the electrical stimulation device of the present invention may be for improving or treating spinal cord injury. Effects of the invention

[0027] According to one embodiment, the implantable magnetic induction-based electrical stimulation patch of the present invention and / or the device including the same is configured to include a hydrogel bioadhesive layer similar to the physical properties of internal organs, thereby enabling precise and sophisticated electrical stimulation of damaged areas within the body, such as the spinal cord, while being tissue-friendly.

[0028] According to one embodiment, the hydrogel bioadhesive layer of the present invention is fixed to an injured site in the body, thereby ensuring long-term stability of an implantable magnetic induction-based electrical stimulation patch and / or a device including the same, even in injured sites in the body such as the spinal cord, which has a lot of moisture and movement.

[0029] According to one embodiment, the implantable magnetic induction electrical stimulation patch of the present invention and / or the device including the same can effectively provide electrical stimulation to the entire organ through magnetic induction-based electrical stimulation without being attached to the entire damaged organ in the body.

[0030] Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims, and drawings. Brief explanation of the drawing

[0031] FIG. 1 is a cross-sectional view schematically showing an implantable electrical stimulation patch according to one embodiment of the present invention. FIG. 2 is a diagram schematically showing various forms of magnetic induction-based electrodes among an implantable electrical stimulation patch according to one embodiment of the present invention. FIG. 3 is a schematic diagram showing an implantable electrical stimulation patch according to one embodiment of the present invention attached to the spinal cord. FIG. 4 is a diagram schematically showing the magnetic field profile of a magnetic induction-based electrode of an implantable electrical stimulation patch according to one embodiment of the present invention. FIG. 5 is an exploded perspective view schematically showing an in-body insertable electrical stimulation patch including an insulating layer according to one embodiment of the present invention. FIG. 6 is an exploded perspective view schematically showing an implantable electrical stimulation patch including a drug layer according to one embodiment of the present invention. Specific details for implementing the invention

[0032] The objects, advantages, and features of the present invention will become more apparent from the following detailed description and embodiments associated with the attached tables and drawings.

[0033] Prior to this, terms and words used in this specification and claims should not be interpreted in their ordinary and dictionary meanings, but should be interpreted in a meaning and concept consistent with the technical spirit of this disclosure, based on the principle that the inventor can appropriately define the concept of the terms to best describe his invention.

[0034] The terms used in this specification are used merely to describe specific embodiments and are not intended to limit the disclosure. The singular expression includes the plural expression unless the context clearly indicates otherwise.

[0035] In this application, terms such as 'comprising' or 'having' are intended to specify the existence of the features, numbers, steps, actions, components, parts, or combinations thereof described in the specification, and should be understood as not precluding the existence or addition of one or more other features, numbers, steps, actions, components, parts, or combinations thereof.

[0036] In this application, when a part is described as "comprising" a certain component, this means that, unless specifically stated otherwise, it does not exclude other components but may include additional components.

[0037] In this specification, descriptions following "e.g." should not limit the embodiments of the invention according to various embodiments of the invention, such as variations including tolerances, measurement errors, limits of measurement accuracy, and other commonly known factors, as the information presented, such as cited characteristics, variables, or values, may not exactly match.

[0038] The present invention is capable of various modifications and may have various embodiments; specific embodiments are illustrated in the drawings and described in detail in the detailed description. However, this is not intended to limit the present invention to specific embodiments, and it should be understood that it includes all modifications, equivalents, and substitutions that fall within the spirit and scope of the present invention. In describing the present invention, if it is determined that a detailed description of related prior art may obscure the essence of the present invention, such detailed description is omitted.

[0039] FIG. 1 is a cross-sectional view schematically illustrating an in-body electrical stimulation patch according to one embodiment of the present invention. Referring to FIG. 1, the in-body electrical stimulation patch (1) of the present invention comprises: a hydrogel bioadhesive layer (100) attached to a part of the body; and one or more magnetic induction-based electrodes (120) provided on one side of the hydrogel bioadhesive layer (100).

[0040] Although not limited to this, the in-body insertable electric stimulation patch (1) of the present invention may be an in-body attachable implantable structure.

[0041] Although not limited thereto, the in-body insertable electric stimulation patch (1) of the present invention may refer to a medical device that transmits electric stimulation by being directly inserted, directly attached, and / or indirectly attached to the body of an animal (organs, nerves, etc.). Although not limited thereto, the in-body insertable electric stimulation patch (1) of the present invention may be used primarily for the treatment of an injured area, nerve stimulation, pain relief, etc.

[0042] Although not limited thereto, the hydrogel bioadhesive layer (100) of the present invention may accurately fix the electric stimulation patch (1) to the damaged organ site. Additionally, although not limited thereto, the hydrogel bioadhesive layer (100) may include a flexible and elastic polymer-based material for direct insertion, direct attachment, and / or indirect attachment into the body of an animal (organ, nerve area, etc.).

[0043] Although not limited to this, the hydrogel bioadhesive layer (100) of the present invention can secure long-term stability with excellent fixation power even in organs with movement and high moisture content by using an adhesive substrate material. Therefore, the magnetic induction-based implantable electrical stimulation patch (1) of the present invention can not only prevent secondary organ damage but also induce effective recovery of organ damage.

[0045] Although not limited thereto, the hydrogel bioadhesive layer (100) of the present invention may be based on a polyacrylamide (PA) type, polyethylene glycol (PEG) type, hyaluronic acid (HA) type, alginate type, or polyvinyl alcohol (PVA) type polymer. More specifically, the polymer may include one or more of polyethylene glycol (PEG), polypropylene glycol (PPG), polyvinyl alcohol (PVA), polyacrylic acid (PAA), poly(N-isopropylacrylamide) (PNIPAM), polycaprolactone (PCL), polylactic acid (PLA), PLGA (poly(lactic-co-glycolic acid)), or polyurethane (PU). Although not limited thereto, using PVA-PAA-NHS (Poly vinyl alcohol - poly acrylic acid - N-hydrooxysuccinimide) as the polymer may be most desirable for ensuring biocompatibility and mechanical stability.

[0046] Although not limited thereto, the hydrogel bioadhesive layer (100) of the present invention may be composed of a biocompatible material. Although not limited thereto, the hydrogel bioadhesive layer (100) of the present invention may be a composite in which a hydrogel is infiltrated into the polymer substrate material, a composite in which a hydrogel is coated onto the polymer substrate material, a composite in which a hydrogel is covalently bonded to the polymer substrate material, or a composite in which the polymer substrate material is surface modified and reacted with the hydrogel.

[0047] Although not limited thereto, the elastic modulus of the hydrogel bioadhesive layer (100) may be 1 MPa or less. Although not limited thereto, the hydrogel bioadhesive layer (100) of the present invention may have physical properties similar to those of an internal organ. Although not limited thereto, the hydrogel bioadhesive layer (100) may exhibit excellent fixation strength when attached to any internal organ that is frequently moving and curved, as it has physical properties similar to those of an internal organ. Although not limited thereto, if the elastic modulus exceeds 1 MPa, the fixation strength may decrease and the structure may detach easily due to the difference in physical properties with the internal organ, and it may cause secondary damage to the internal organ.

[0048] Although not limited thereto, the magnetic induction-based electrode (120) may be a metal thin film, a liquid metal, a conductive polymer, or include one or more of these. Although not limited thereto, the magnetic induction-based electrode (120) is provided on a hydrogel bioadhesive layer (100) and can form a magnetic field upon the application of current. Additionally, an electric field and / or induced current may be generated within the damaged tissue by the magnetic field that changes over time, thereby stimulating nerve cells, etc.

[0049] Although not limited thereto, the metal thin film may be a metal thin film comprising one or more of gold, titanium, platinum, iridium, and / or stainless steel.

[0050] Although not limited thereto, the liquid metal may be a metal containing one or more of gallium, indium, tin, and / or zinc.

[0051] Although not limited thereto, the conductive polymer may be PEDOT:PSS (a composite of poly(3,4-ethylenedioxythiophene) and poly(styrene sulfonate). Although not limited thereto, the PEDOT:PSS is a biocompatible conductive polymer, and when used as a magnetic induction-based electrode (120), it may have a low immune response in the body and excellent flexibility.

[0053] FIG. 2 is a schematic diagram illustrating various forms of a magnetic induction-based electrode among an implantable electrical stimulation patch according to one embodiment of the present invention. Referring to FIG. 2, the magnetic induction-based electrode (120) may include, but is not limited to, a circular coil composed of a conductive material. The conductive material may include, but is not limited to, a metal thin film, a liquid metal, a conductive polymer, or one or more of these. When a circular coil is used, but is not limited to, the magnetic induction-based electrode can deliver a wide and deep, uniform electrical stimulation to the entire damaged area.

[0054] Although not limited thereto, the circular coil may comprise one or more circular coils and / or a predetermined arrangement of circular coils depending on the damaged area. Although not limited thereto, for example, referring to (a) of FIG. 2, the circular coil may include one approximately circular or elliptical circular portion (121) provided between a pair of power terminal portions (122) and power terminal portions (122); referring to (b), it may include two circular coils; and referring to (c), it may include four circular coils. Although not limited thereto, according to one embodiment, the magnitude of stimulation applied to a specific area may be adjustable by increasing or decreasing the number of coils. Although not limited thereto, if the number of coils increases, the distortion of the induced magnetic field compared to a single coil is reduced, and a uniform electromagnetic field distribution is formed, thereby reducing the error in the recovery effect of the damaged area and enabling the securing of a reproducible treatment effect. Although not limited to this, the number and arrangement of coils can be adjusted according to the location or extent of damage in patients with organ damage to configure an implantable electric stimulation patch (1) tailored to the patient.

[0055] The above-described circular coil may be made of a flexible material and / or have a shape. According to the above configuration, when the circular coil is attached to an internal organ, the adhesion and / or ease of use in organs with many movements and curved surfaces can be improved.

[0057] FIG. 3 is a schematic diagram showing an implantable electrical stimulation patch according to one embodiment of the present invention attached to the spinal cord, and FIG. 4 is a schematic diagram showing the magnetic field profile of a magnetic induction-based electrode of an implantable electrical stimulation patch according to one embodiment of the present invention.

[0058] Although not limited thereto, when there are multiple circular coils, at least one of the diameter, line width, number of turns, spacing, or arrangement position of each circular coil may be different, so that each circular coil may form a different magnetic induction range. Although not limited thereto, the magnetic induction range can be easily adjusted by adjusting at least one of the diameter, line width, number of turns, spacing, or arrangement position of each circular coil.

[0059] Referring to FIGS. 3 and 4, although not limited thereto, the electrode pattern of the present invention is designed in the form of a coil by patterning a conductive material, and when current is applied, a magnetic field is generated from the circular coil-shaped electrode, which can induce an induced current in the surrounding tissue to induce depolarization and increase plasticity of nerve cells.

[0060] Unlike conventional electrode-implantable spinal cord stimulators or TMS external stimulation systems, this institute has implemented electromagnetic field principles within an implantable device.

[0061] The present invention utilizes a conductive material to print a circular electrode structure onto a hydrogel bioadhesive layer, thereby simultaneously ensuring biocompatibility and mechanical stability. Since internal organs are tissues that are constantly moving, it is crucial that the attached device does not detach and maintains stable physical contact.

[0062] The hydrogel bioadhesive layer of the present invention has excellent fixation power even on tissue surfaces containing moisture, and at the same time maintains electrical connection stability with the electrode, thereby ensuring long-term stimulation efficiency.

[0063] Although not limited to this, the magnetic induction-based electrical stimulation patch of the present invention generates an electromagnetic field based on magnetic induction, allowing stimulation to be applied to a wide range of the organ even when attached to only a part of the damaged area in the body.

[0064] Furthermore, the present invention differs from conventional methods that use a circular coil magnetic induction electrode to stimulate organs that are difficult to stimulate internally because they are blocked by bone, such as the spinal cord, by wrapping the electrode around them 360°. In other words, the magnetic induction-based electrical stimulation patch of the present invention can induce the recovery of nerve cells by generating an induced current throughout the organ by closely attaching it to a part of the damaged organ. The electrical stimulation patch of the present invention forms a magnetic field by passing current through a circular coil, and by generating an induced current within the tissue through this magnetic field, it can deliver electrical stimulation to a wide area of ​​the target organ while minimizing tissue damage.

[0065] In other words, the present invention can deliver induced current over a deep and wide range via a magnetic field without the need for the electrode to physically wrap around the entire organ, thereby minimizing the risk of tissue damage that may occur with conventional electrode-based stimulation methods while maximizing stimulation efficiency. Additionally, stimulation can be delivered directly to the injured site through an adhesive structure, and high stability and adhesion can be maintained even when attached to an organ using a hydrogel-based fixation mechanism.

[0067] FIG. 5 is an exploded perspective view schematically illustrating an in-body insertable electric stimulation patch (10) including an insulating layer according to one embodiment of the present invention. Referring to FIG. 5, the electric stimulation patch (1) of the present invention may have one or more insulating layers (110, 130) between the hydrogel bioadhesive layer (100) and the magnetic induction-based electrode (120); and / or on one side of the magnetic induction-based electrode.

[0068] That is, the insulating layer (110, 130) may be formed between the magnetic induction-based electrode (120) and the hydrogel bioadhesive layer (100) and / or on one side of the magnetic induction-based electrode (120) to prevent electrode corrosion, prevent interfacial peeling, and block reverse current.

[0069] Although not limited thereto, the hydrogel bioadhesive layer (100) may have high ion conductivity, so current leakage of the electrode may occur, which may reduce the stimulation efficiency. Therefore, although not limited thereto, it may be preferable to have both the first insulating layer (110) and the second insulating layer (130).

[0071] FIG. 6 is an exploded perspective view schematically illustrating an in vivo insertable electrical stimulation patch (10) containing a drug according to one embodiment of the present invention. Referring to FIG. 6, the hydrogel bioadhesive layer (100) may further include a drug (101), though it is not limited thereto. The drug (101) may be formed on the hydrogel bioadhesive layer or may be included in the hydrogel bioadhesive layer (100), though it is not limited thereto.

[0072] The drug may be a sustained-release drug, a biodegradable drug capsule, a nanoparticle-bound drug, and / or a tissue regeneration promoter, but the type thereof may not be limited as long as it does not impair the physical properties of the present invention. For example, the drug may be an anti-inflammatory agent (dexamethasone), a growth factor (VEGF), and / or an antibiotic.

[0074] Although not limited thereto, the implantable electrical stimulation patch of the present invention may be used for the improvement or treatment of spinal cord injury. Although not limited thereto, the implantable electrical stimulation patch of the present invention can deliver stimulation to deep areas without wrapping the spinal cord. Although not limited thereto, the implantable electrical stimulation patch of the present invention can generate a magnetic field by electromagnetic induction by applying current to a circular coil electrode printed with a conductive material, and the magnetic field can stimulate nerve cells by generating an induced current within the spinal cord tissue. Through this, it is possible to stimulate deep nerves without wrapping the spinal cord, which is difficult to stimulate physically. Therefore, according to the above configuration, the problem of the risk of secondary spinal cord injury associated with the prior art, which required wrapping the spinal cord 360° to stimulate the entire spinal cord, can be resolved.

[0076] The electrical stimulation device of the present invention comprises an electrical stimulation patch comprising: a hydrogel bioadhesive layer attached to a part of the body; and one or more magnetic induction-based electrodes provided on one side of the hydrogel bioadhesive layer.

[0077] Although not limited to this, the electrical stimulation device of the present invention is flexible and deformable rather than rigid when implanted in the body, and can accommodate the movement of nerve tissue, making it suitable for organ attachment. Unlike conventional electrode stimulation devices with limited application sites, it can be custom-designed and attached to various locations on organs, and since it has a structure that generates a magnetic field within the device itself without the insertion of additional circuits, it enables device miniaturization and simplified procedures.

[0078] The electrical stimulation device of the present invention may include, but is not limited to, a power source connected to the magnetic induction-based electrode via a wired and / or wireless connection. However, in the case of a wirelessly connected power source, it may have the advantages of enabling miniaturization, allowing for long-term operation without battery replacement, and allowing the patient to move conveniently.

[0079] Although not limited to this, the electric stimulation device of the present invention can be suitable for long-term transplantation by printing a flexible conductive electrode on a highly biocompatible hydrogel bioadhesive layer, thereby stably fixing it even with tissue movement.

[0080] Although not limited thereto, the magnetic induction-based electrode of the present invention may include a circular coil structure utilizing the magnetic induction principle of TMS, and can effectively deliver electrical stimulation to areas that are anatomically difficult to stimulate through electromagnetic induction. Although not limited thereto, the circular coil electrode of the magnetic induction-based electrode may be composed of one or more coils. Although not limited thereto, as the number of coils increases, the magnitude of stimulation applied to a specific area can be adjusted, thereby stimulating the damaged area more specifically to induce a rapid recovery effect.

[0081] In addition, although not limited thereto, applying current to multiple coils with a time delay allows for stimulation of the damaged area in various patterns, which can be effective for inducing plasticity for nerve recovery. Although not limited thereto, increasing the number of coils reduces distortion of the induced magnetic field compared to a single coil and forms a uniform electromagnetic field distribution, thereby reducing errors in the recovery effect of the damaged area and enabling the securing of reproducible therapeutic effects. Although not limited thereto, a patient-customized device can be configured by adjusting the number and arrangement of coils according to the location or extent of damage in patients with organ damage.

[0082] In addition, if integrated with an AI-based stimulation optimization system, the optimal time and / or intensity can be applied according to the patient's condition to maximize the therapeutic effect.

[0083] The electrical stimulation device of the present invention may induce the recovery of nerve cells, although it is not limited thereto. The electrical stimulation device of the present invention generates an induced current through a magnetic field produced by a circular electrode coil without having to completely cover the damaged area like conventional electrodes, thereby inducing depolarization and recovery of nerve cells, and can be utilized as a core therapeutic technology in various clinical fields such as rehabilitation medicine, neurosurgery, and orthopedics.

[0084] The present invention may be used for improving or treating spinal cord injury, although it is not limited thereto. The present invention is designed to allow stimulation to reach the entire tissue through electromagnetic field diffusion without physically enveloping the spinal cord, thereby enabling therapeutic effects that overcome anatomical limitations. The present invention may be used for improving or treating spinal cord injury, provided that the electrical stimulation device with an adhesive hydrogel-based structure is stably fixed to water-rich tissues such as the spinal cord, and since the electrodes are flexible and biocompatible, long-term attachment is possible, thereby providing an electrical stimulation device capable of structural stability, depth and range of stimulation, and minimization of tissue damage.

[0086] Although an embodiment of the present invention has been described above, those skilled in the art may modify and change the present invention in various ways by adding, changing, deleting, or adding components, etc., without departing from the spirit of the present invention as described in the claims, and such modifications and changes are also to be included within the scope of the rights of the present invention. Explanation of the symbols

[0087] 1, 10: Implantable electrical stimulation patch 100: Hydrogel bioadhesive layer 101: Drugs 110: First insulating layer 120: Magnetic induction-based electrode 121: Circular part 122: Power terminal section 130: Second insulating layer

Claims

Claim 1 An implantable electrical stimulation patch comprising: a hydrogel bioadhesive layer attached to a body part; and one or more magnetic induction-based electrodes provided on one side of the hydrogel bioadhesive layer. Claim 2 An implantable electrical stimulation patch according to claim 1, wherein the hydrogel bioadhesive layer is based on a polyacrylamide (PA), polyethylene glycol (PEG), hyaluronic acid (HA), alginate, or polyvinyl alcohol (PVA) type polymer. Claim 3 An implantable electrical stimulation patch according to claim 1, wherein the elastic modulus of the hydrogel bioadhesive layer is 1 MPa or less. Claim 4 An implantable electrical stimulation patch according to claim 1, wherein the magnetic induction-based electrode is a metal thin film, a liquid metal, a conductive polymer, or a mixed type comprising one or more of the same. Claim 5 An implantable electrical stimulation patch according to claim 1, wherein the magnetic induction-based electrode comprises a circular coil composed of a conductive material. Claim 6 An implantable electrical stimulation patch according to claim 5, wherein the circular coil comprises one or more of the circular coils and / or a predetermined arrangement of the circular coils depending on the site of injury. Claim 7 An intangible electrical stimulation patch according to claim 5, wherein when there are multiple circular coils, at least one of the diameter, line width, number of turns, spacing, or arrangement position of each circular coil is different, so that each circular coil forms a different magnetic induction range. Claim 8 An implantable electrical stimulation patch according to claim 1, comprising one or more insulating layers between the hydrogel bioadhesive layer and the magnetic induction-based electrode; and / or on one side of the magnetic induction-based electrode. Claim 9 An implantable electrical stimulation patch according to claim 1, wherein the hydrogel bioadhesive layer contains a drug. Claim 10 In paragraph 1, an implantable electrical stimulation patch for improving or treating spinal cord injury. Claim 11 An implantable electrical stimulation patch according to claim 1, which is inserted into the body and attached to a part of the damaged area. Claim 12 An electrical stimulation device comprising an implantable electrical stimulation patch as described in claim 1. Claim 13 An electrical stimulation device according to claim 12, comprising: a hydrogel bioadhesive layer attached to a body part; one or more magnetic induction-based electrodes provided on one side of the hydrogel bioadhesive layer; and a power source connected to the magnetic induction-based electrodes via wired and / or wireless connections. Claim 14 An electrical stimulation device that induces the recovery of nerve cells in Clause 12. Claim 15 In Clause 12, an electrical stimulation device for improving or treating spinal cord injury.

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